Relevant bibliographies by topics / Carabane

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Carabane'

Author: Grafiati
Published: 9 September 2021
Last updated: 1 February 2022

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Journal articles on the topic "Carabane"

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Ludovice, Nicolo Paolo P. "The Carabao and the Encounter of the Law in Nineteenth-Century Philippines." Society & Animals 27, no. 3 (June 13, 2019): 307–26. http://dx.doi.org/10.1163/15685306-12341557.

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AbstractThe place of the non-human animal in the legal world has been questioned. Animals’ legal status as property has been probed on how to best protect their welfare. While this is significant for animals who are not on the farm, it might not be effective when considering animals raised for food. The case of the carabao, or the water buffalo, in the Philippines is seen as a hybrid. This article traces the development of the carabao in Philippine history during the nineteenth century. Through historical, archival, and legal research on animals, the carabao is situated as private property. Colonial instruments of control were introduced to protect the carabao from criminals. In its proper historical context, the classification of carabaos as property indeed highlighted the animal’s status as legally owned, which did not necessarily demean the animal’s relationship with the human peasant nor the carabao’s quality as an animal.
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Erwin, Terry L. "The ground beetles of Central America (Carabidae) I: Carabinae (in part): Notiophilini, Loricerini, Carabini." Smithsonian Contributions to Zoology, no. 501 (1991): 1–30. http://dx.doi.org/10.5479/si.00810282.501.

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Avgin, Sakine Serap, and Hüseyin Özdikmen. "Additional Records of the Distribution and Occurrence of Carabid Beetles (Coleoptera: Carabidae) in Turkey." Journal of Entomological Science 43, no. 4 (October 1, 2008): 381–93. http://dx.doi.org/10.18474/0749-8004-43.4.381.

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Forty-nine species/subspecies of carabid beetles (Coleoptera: Carabidae) were identified from specimens previously collected from several locations in Turkey. The identified specimens represented the subfamilies Carabinae (Tribe Carabini), Nebriinae (Tribe Notiophilini), Trechinae (Tribe Bembidiini), Pterostichinae (Tribes Agonini, Pterostichini, Zabrini), Harpalinae (Tribe Harpalini), Callistinae (Tribes Licinini, Callistini), Lebiinae (Tribe Lebiini), and Brachininae (Tribe Brachinini). The majority (n = 20) of species/subspecies represented the subfamily Harpalinae. All species/subspecies identified had been previously reported from Turkey; however, the reported distribution of each was expanded into additional provinces with this study. The majority of the new records were from Niğde (n = 24) and Ankara (n = 15). Other new records were from Aksaray (5), Nevşehir (3), Sinop (2), Samsun (2), Rize (2), Afyon (1), Konya (1), and Kayseri (1). These data add to our knowledge of carabid distribution in Turkey.
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Gersh, Stephen. "John Scottus Eriugena. Deirdre Carabine." Speculum 78, no. 3 (July 2003): 851–52. http://dx.doi.org/10.1017/s0038713400131653.

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San Diego, Lean Angelo B., Marvin Bryan S. Salinas, Angelica C. Bumanlag, Marlon B. Ocampo, and Lerma C. Ocampo. "Viability of carabao (Bubalus bubalis carabanensis) epididymal sperm from post mortem testes in semen extender at refrigerated temperature." Entomology and Applied Science Letters 4, no. 2 (May 5, 2017): 5. http://dx.doi.org/10.24896/easl2017422.

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Post mortem epididymal sperm (ES) is an excellent source of germplasm for conservation of animal genetic resources. In this study, the viability of post mortem ES from carabao after collection at ambient temperature (AT) and after 24 hr and 48 hr of storage at refrigeration temperature (RT) were evaluated. ES were collected through slicing of epididymides from 7 carabaos. The mean ES volume was 0.4 ml with sperm concentration of 2.5×109 cells/ml. The mean percentage livability of fresh ES, after 24 hr and 48 hr of storage at RT were 81.93%, 65.93% and 43.7%, respectively. The mean percentage abnormalities of fresh ES, after 24 hr and 48 hr of storage at RT were 44.15%, 38.5% and 43.47%, respectively. The mean percentage motility of fresh ES, after 24 hr and 48 hr of storage at RT were 60.0%, 50.0% and 17.24%, respectively, after analysis through conventional means. Through CASA, the mean percentage motility was observed to be lower significantly at 26.12%, 37.94% and 18.32% for fresh ES, after 24 hr and 48 hr of storage at RT, respectively. The mean progressive motility of fresh ES, after 24 hr and 48 hr storage at RT were 10.02%, 16.47% and 10.87%, respectively. The results suggest that ES potential for use in fertilization studies remained viable when used immediately or after storage at RT for the first 24 hr.
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Ringanadépoullé, Séverine. "La tradition carabine de l’internat de médecine." Psychologie clinique et projective 26, no. 1 (2020): 47. http://dx.doi.org/10.3917/pcp.026.0047.

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Xu, Jing, Peng Zhang, Zhongjun Ma, Yuanqiang Guo, Xiaojun Zhao, and Kun Wei. "Two carabrane-type sesquiterpenes from Vladimiria souliei." Phytochemistry Letters 2, no. 4 (November 2009): 204–6. http://dx.doi.org/10.1016/j.phytol.2009.08.001.

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Su, Zhi-Hui, Yûki Imura, and Syozo Osawa. "Evolutionary Discontinuity of the Carabine Ground Beetles." Journal of Molecular Evolution 53, no. 4-5 (October 1, 2001): 517–29. http://dx.doi.org/10.1007/s002390010242.

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Gonzáles, Paúl, Blanca León, Asunción Cano, and Peter M. Jørgensen. "Vascular flora and phytogeographical links of the Carabaya Mountains, Peru." Revista peruana de Biología 25, no. 3 (September 25, 2018): 191. http://dx.doi.org/10.15381/rpb.v25i3.15228.

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Los estudios sobre la composición florística y riqueza de especies en montañas tropicales apoyan su reconocimiento como áreas de alta diversidad biológica, y, por tanto, de su importancia para la conservación. En este trabajo presentamos datos sobre la flora altoandina de ocho sitios localizados en la Cordillera de Carabaya, proveemos también una comparación florística con otros nueve lugares tanto en Perú como en el norte de Bolivia. El área de estudio incluye 506 especies de plantas vasculares, reconocidas en 203 géneros y 66 familias. Las tasas más altas de riqueza de especies se hallan en dos familias: Asteraceae y Poaceae, que colectivamente abarcan el 37% de todas las especies. Otras familias importantes fueron Caryophyllaceae, Fabaceae, Malvaceae, Brassicaceae, Caprifoliaceae, Gentianaceae, Plantaginaceae y Cyperaceae. Los géneros más diversos fueron Senecio, Calamagrostis, Poa y Nototriche. La forma de crecimiento predominante fueron las hierbas perennes. La flora vascular de la Cordillera Carabaya está muy relacionada con otras regiones del sur de Perú. Además, más de la mitad de todas las plantas vasculares registradas para la Cordillera Carabaya se encuentran en la región andina de Bolivia, lo que demuestra la indudable conexión geofísica y fitogeográfica entre las cordilleras Carabaya y Apolobamba de Bolivia. Este estudio también demuestra la necesidad de una extensa colección botánica y futura exploración, desde que Carabaya, como otras partes de los altos Andes del Perú, están sujetos a cambios dramáticos que amenazan las poblaciones de esas plantas.
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Jiang, Wei, Xiaoyan Zhou, Zengxia Li, Kaiyu Liu, Weige Wang, Renke Tan, Xiaoji Cong, et al. "Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin." Blood 131, no. 12 (March 22, 2018): 1325–36. http://dx.doi.org/10.1182/blood-2017-07-794875.

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Key Points P4HA2, associated with progression and poor overall survival in DLBCL patients, could serve as a novel biomarker and therapeutic target. P4HA2 counteracts the negative effect of Carabin on lymphoma by hydroxylation of Carabin at Pro306.
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Dissertations / Theses on the topic "Carabane"

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Leitão, Francisco Afonso de Carvalho Pinheiro. "Paraísos cruzados: itinerários simétricos em Carabane, uma ilha turística no Sul do Senegal." Master's thesis, Faculdade de Ciências Sociais e Humanas, Universidade Nova de Lisboa, 2012. http://hdl.handle.net/10362/7552.

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Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Antropologia: Culturas Visuais
Em Carabane, ilha turística da região da Casamansa, no Sul do Senegal, cruzam-se as rotas de turistas, emigrados e expatriados ocidentais locais e ainda as perspectivas de migração para o Ocidente de uma parte da população local. O resultado dessa confluência neste cenário é o ponto de partida para uma maquetagem da heterogeneidade de discursos e práticas que se processam no seio dessa economia negociada de desejos mútuos, profundamente enformada pelas lógicas de sentido contemporâneas.
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Moncoquet, Paul. "Carabaya Kallawaya." Lille 3 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37599780n.

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Moncoquet, Paul. "Carabaya kallawaya." Université Marc Bloch (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR20022.

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Les carabaya du perou et les kallawaya de bolivie formaient aux temps preincaiques et dans l'inkanato un seul kurakazgo ou chefferie dont les deux "moities, hatun et huchuy, furent separees pendant la colonie espagnole. Les carabaya kallawaya ont joue un role politique dans le tawantinsuyu et leur territoire fut la porte d'acces au monde des chunchu et des anti. En outre ils furent privilegies de l'inka. Cela est du au fait que leurs activites ont revetu, et revetent encore un caractere sacral et symbolique eminent : la moitie hatun carabaya etait specialisee dans la production d'or, de coca et de mais tandis que la moitie huchuy carabaya formait des medecinsguerisseurs itinerants, detenteurs de secrets shamaniques. Les textes anciens mais aussi la tradition vecue aujourd'hui permettent de retrouver l'unite de l'ancien kurakazgo coupe en deux par les aleas de l'histoire. Au-dela de la separation, les carabaya du perou et les kallawaya de bolivie ont perpetue de maniere parallele leur tradition commune et la complementarite des deux "moities" et ont maintenu de maniere vivante leur vision du monde en assimilant des elements noueaux de la modernite. Cela peut se reconnaitre au travers du systeme de representations et dans les realisations et les techniques, en particulier la medecine et le tissage dont l'aspect symbolique est evident. D'un cote comme de l'autre de la frontiere, les carabaya kallawaya ont developpe des strategies d'adaptation et de resistance parfois differentes, mais ils demeurent reconnaissables comme une entite ethnique
Carabaya people from peru and kallawaya people from bolivia formed before the inka times and in the inkanato a single kurakazgo or chieftainship whose the two halves, hatun and huchuy, have been separated during the spanish colony. Carabaya kallawaya have played a political part in the tawantinsuyu and their territory has been the gateway to the chunchu's and anti's world. Moreover, they have been favoured by the inka. This is due to the fact that their activities have taken on, and still take on an eminent sacred and symbolic character : the hatun carabaya half was specialized in the gold production, coca and corn, whereas the huchuy carabaya half turned out itinerant healer-medicine men, holder from shamanic secrets. Ancient texts, but also the tradition lived today permit to rediscover the unity of the ancient kurakazgo cut in two by the hazards of history. Beyond the parting, carabaya from peru and kallawaya from bolivia perpetuated in a parallel way their common tradition and the complementarity from the two halves and have maintained alive their perception from the world by assimilation of new elements from modernity. This is recognizable through the representation system and in the realizations and technics, particularly in the medicine art and in the weawing whose the symbolic aspect is obvious. On both sides of the border, carabaya kallawaya have unfolded strategies of adaptation and resistance sometimes different, but they are still recognizable as an ethnical entity
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Breckler, Magali. "Mise en évidence des effets anti-hypertrophiques de carabine dans le cardiomyocyte et caractérisation de ses voies de signalisation." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T014/document.

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L’hypertrophie cardiaque est un mécanisme adaptatif qui se développe en réponse à une surcharge de travail hémodynamique. Lors d’un stress chronique, elle peut mener à l’insuffisance cardiaque (IC), l’une des principales causes de mortalité dans les pays industrialisés. Les voies de signalisation hypertrophiques induites par les récepteurs α et β-adrénergiques font intervenir la petite protéine G Ras et des protéines calcium-dépendantes telles que la calcineurine (CaN) et la Ca2+/calmoduline-dépendante kinase de type II (CaMKII), ainsi que leurs facteurs de transcription respectifs NFAT et MEF2. Dans les cellules immunitaires, la protéine Carabine a été mise en évidence comme inhibant la CaN et de Ras. L’objectif de cette thèse et de caractériser son rôle dans le cardiomyocyte.In vitro, nous montrons que Carabine est exprimée dans le cardiomyocyte de rat nouveau-né et adulte et inhibe par l’intermédiaire de ses domaines fonctionnels les voies de signalisation de Ras/ERK, CaN/NFAT et CaMKII/MEF2. Sous stimulation chronique adrénergique, la surexpression de Carabine prévient le remodelage cardiaque en bloquant le développement des marqueurs de l’hypertrophie : la croissance cellulaire, la réexpression des gènes foetaux etla réorganisation des protéines contractiles. Enfin, dans un modèle d’hypertrophie cardiaque induite par surcharge de pression chez le rat, l’injection intramyocardiaque d’un adénovirus codant pour Carabine inhibe l’hypertrophie des cardiomyocytes. Ce travail ouvre ainsi de nouvelles perspectives thérapeutiques pour le traitement de l’IC
Cardiac hypertrophy is an adaptative mechanism developed in response to hemodynamic overload. During chronic stress, it can lead to heart failure (HF), one of the most important causes of mortality in industrialized countries. Hypertrophic signaling pathway induced under α and β-adrenergic receptor involve small G protein Ras and calcium dependent proteins suchas the calcineurine (CaN) and the Ca2+/calmodulin-dependent protein kinases II (CaMKII), as well as their respective transcription factors NFAT and MEF2. In immune cells Carabin protein has been shown to inhibit CaN and Ras. The purpose of my thesis was to determine the role of Carabin in the cardiomyocyte.In vitro, we showed that Carabin is expressed in neonatal and adult rat cardiomyocyte and inhibits via its functional domains the Ras/ERK, CaN/NFAT and CaMKII/MEF2 signaling pathways. Under adrenergic chronic stimulation, Carabin overexpression blocks the development of hypertrophic markers (cell size increase, re-expression of embryonic genesand contractile protein reorganisation) preventing thus cardiac remodeling. Finally, in a rat model pressure overload cardiac hypertrophy, intra-cardiac injection of Carabin adenovirus inhibits cardiomyocyte growth. This study opens new insights into the treatment of HF
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Godeau, Emmanuelle. ""La coutume des carabins" : ethnologie de l'internat." Paris, EHESS, 2004. http://www.theses.fr/2004EHES0046.

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L'apprentissage des médecins spécialistes français est analysé à travers des pratiques coutumières liminales dotées d'une efficacité symbolique. Dans cet apprentissage, plusieurs étapes apparaissent. D'abord les dissections, différenciant pour toujours les futurs médecins de ceux qui ne le seront jamais. Puis, après avoir précisé les spécificités de l'internat, les "manières" que les internes ont à acquérir: du baptême redoublant leur réussite au concours, aux règles gouvernant un savoir vivre propre aux salles de garde, jusqu'à l'enterrement qui clôture la vie d'interne et confirme leur maîtrise des registres carabins. L'analyse des revues, spectacles satiriques montés par les jeunes pour les anciens, met en évidence continuité et cohérence du parcours et des logiques coutumières analysés. Ces années de formation constituent une véritable initiation, transformant à jamais ceux qui la subissent. Son originalité réside dans le fait que savoirs officiel et traditionnel se construisent ensemble à l'hôpital, comme dans l'objet même de l'apprentissage médical qui nécessite la transgression répétée des tabous de la mort, la nudité et la sexualité
The training of specialised French physicians is studied through liminary behaviours belonging to cultural customs, with their own symbolic efficacy. During internship, some stages appear. First, dissections, which will forever differentiate doctors from all others. Next, after discussion of specifics about French internship, the "manners" students have to learn during their internship: a baptism celebrates their entrance into their new community; specific rules or manners characteristic to their staff waiting rooms; finaly, funerals which end their lives as interns. In addition, revues, satirical shows created by the youngest for the eldest, show the continuity and coherence of the career and the logic of the cultural customs studied here. Finaly, these apprenticeship years appear as a true initiation that changes those who go through it as such forever. The originality of this training lies first in the fact that official and traditional knowledges are built and learned together, in the middle of the hospital; and second in the subject of medical training itself, which leads to repeated transgression of the taboos of death, nudity and sexuality
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Osorio, Gonzales Oscar Guillermo. "Pasado y presente del Jirón Carabaya (1883-1930)." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2016. https://hdl.handle.net/20.500.12672/4965.

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Esta investigación se desarrolla en cuatro capítulos. En el primer capítulo se aborda las características generales de las cinco cuadras objeto de estudio del Jr. Carabaya. Es necesario tener muy presente los datos de esta parte ya que serán muy utilizados a lo largo de la investigación. En el segundo capítulo se aborda el periodo 1883 hasta 1900, con antecedentes desde 1840, en el cual se generan los primeros cambios en el Jr. Carabaya y que coincide con el inicio del abandono de los viejos predios por parte de las clases altas de Lima. El tercer capítulo aborda las dos primeras décadas de 1900, hasta el inicio del Oncenio. El cuarto y último capítulo analiza el Oncenio, hasta 1930, periodo importante de transformaciones en el Jirón Carabaya, así como de cambios en el uso del espacio a lo largo de las calles. En resumen, en el primer capítulo se plantea el objetivo de una comprensión holística y externa del Jirón Carabaya en sus cinco cuadras. Los capítulos restantes tienen como objetivo entender la problemática de los cambios en el Jr. Carabaya entre 1883-1900, 1900-1920 y 1920-1930, como parte de la comprensión de una parte de la situación actual del patrimonio en el centro histórico de Lima.
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Olofsson, Emil. "CARABAS III Konstruktion av antenninstallation på helikopter." Thesis, KTH, Maskinkonstruktion (Inst.), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-99891.

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This report describes the construction work of a radar antenna for the radar system CARABAS. CARABAS is a long wave airborne ground radar that has been developed by SAAB Microwave Systems and will now be mounted on a small helicopter, Schweizer 300. The antenna should be able to fold up and down. When the radar is in use the antenna is lowered and under transport, start and landing the antenna is folded up. An emergency drop function should also be included in the design of CARABAS III. The extent of this report includes construction of the antenna, frame structure attached to the helicopter, mechanism for folding the antenna up and down and mechanism for emergency drop function. The mechanical design of the antenna and frame structure is based on modal and stress analysis, vibration measurement of Schweizer 300 and frequency analysis, and calculations regarding aerodynamic drag and mechanics. The exciting frequencies of the helicopter and accelerations at those frequencies were determined by vibration measurement and frequency analysis. Including outer exciting frequencies, frequencies of the main rotor, complete information of where the antennas eigenfrequencies should lie was established. The design of the antenna and frame structure and the laminate composition in the antenna was determined by the modal analysis of the total system, both antenna and frame structure. Hence the systems eigenfrequencies does not coincide with the exciting frequencies of the helicopter. The frame structure is pressed against the cargo frame of the helicopter at four support points by a mechanism consisting of a beam with a pin joint and a spring loaded bolt. The beam is attached to the cargo hook of the helicopter which can be opened from the cockpit. Hence CARABAS III can be released from the helicopter in case of emergency. The loads on antenna and frame structure constitute of drag and inertia forces and were calculated analytically. The loads were used as input data in the stress analysis performed on antenna and frame structure and to design the folding mechanism and mechanism for pretention of the frame structure against the cargo frame. According to the performed stress analysis the antenna and components in the frame structure will hold the loads that they are subjected to.
Denna rapport behandlar konstruktionsarbetet av en antenninstallation till radarsystemet CARABAS. CARABAS är en långvågig luftburen markradar som utvecklats av SAAB Microwave Systems och som nu ska installeras på en helikopter av typ Schweizer 300. Antennbäraren ska kunna fällas ned vid mätning och fällas upp vid start, landning och transport. Dessutom ska antennbäraren kunna nödfällas. Omfattningen av rapport inkluderar konstruktion av bärare av antennelement, ramstruktur som fästs mot helikoptern, upp och nedfällningsmekanism samt mekanism för nödfällning. Konstruktionsarbetet baseras på modal- och spänningsanalyser, vibrationsmätning och frekvensanalys, samt flödesberäkningar och mekaniska beräkningar. Helikopterns exciteringsfrekvenser och accelerationer vid dessa bestämdes genom vibrationsmätning och genom efterföljande signalbehandling. Tillsammans med exciteringsfrekvenser från yttre excitationskällor från huvud- och stjärtrotor skapades ett komplett underlag av var antennbärarens egenfrekvenser bör ligga och vilka frekvenser som måste undvikas. Modalanalys av det totala systemet, det vill säga både antennbärare och ramstruktur, ligger som grund för geometrisk utformning av antennbäraren och ramstrukturen och för komposituppbyggnad i antennbäraren. Då dessa konstruerades så att systemets egenfrekvenser inte sammanfaller med helikopterns egenfrekvenser. Upp och nedfällningsmekanismen konstruerades med två gasfjädrar som jobbar parallellt med ett linjärt ställdon, gasfjädrarna vill föra antennbäraren till uppfällt läge och ställdonet tvingar den till nedfällt läge. Ramstrukturen trycks mot helikopterns lastram i fyra stödpunkter med en mekanism bestående av en fjäderbelastad skruv och en ledad balk. Den ledade balken fästs till helikopterns lastkrok som kan öppnas elektriskt och mekaniskt från helikoptern. Genom denna konstruktion kan CARABAS III nödfällas. Laster som verkar på antennbärare och ramstruktur utgörs av luftlaster och tröghetslaster, dessa beräknades analytiskt. Beräknade laster användes sedan som indata till spänningsanalyser av antennbärare och ramstruktur samt för att dimensionera mekanismen för upp- och nedfällning av antennbäraren och förspänningsmekanismen mot lastramen. Enligt de genomförda analyserna håller antennbäraren och samtliga komponenter i ramstrukturen för de belastningar som de utsätts för.
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Walter, Fredrik. "Extraction of forest stand parameters from CARABAS VHF SAR images /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5649-5.pdf.

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Krucien, Nicolas. "Mise en évidence des effets anti-hypertrophiques de carabine dans le cardiomyocyte et caractérisation de ses voies de signalisation." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00807172.

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Les systèmes de santé accordent une attention croissante au point de vue des usagers dans l'organisation de l'offre de soins. L'instauration d'une offre de soins sensible aux besoins et préférences des patients constitue un enjeu majeur de qualité et d'efficacité des soins. Ce travail analyse le point de vue des patients pour l'offre de soins de médecine générale en utilisant différentes méthodes permettant d'obtenir des informations complémentaires en termes d'expérience de soins, de satisfaction, d'importance ou encore de préférences. Il s'agit des méthodes Delphi, de classement du meilleur au pire et de révélation des préférences par les choix discrets. Ces méthodes sont appliquées sur deux échantillons : en population générale pour la première et chez des patients poly-pathologiques pour les 2 autres afin d'identifier les principaux enjeux actuels et à venir de la réorganisation de l'offre de soins de médecine générale du point de vue des patients. Les résultats montrent le rôle central de la relation médecin-patient et plus particulièrement de l'échange d'informations entre le médecin et le patient. Cependant une relation médecin-patient de qualité ne doit pas pour autant être réalisée au détriment de la qualité technique du soin et de la coordination de la prise en charge du patient. Ce travail montre également l'importance de prendre en compte l'expérience de soins des patients lors de l'analyse de leur point de vue, et plus particulièrement de leur disposition au changement. L'évaluation systématique et régulière des préférences des patients en pratique quotidienne peut permettre d'améliorer la communication médecin-patient ainsi que le contenu de l'offre de soins du point de vue des patients.
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Bisserier, Malik. "Rôles et mécanismes d'action des protéines Carabin et Epac1 dans l'hypertrophie et l'insuffisance cardiaque." Toulouse 3, 2015. http://www.theses.fr/2015TOU30020.

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L'hypertrophie cardiaque (HC) est un mécanisme adaptatif qui se développe en réponse à un stress hémodynamique. Lorsque ce stress devient chronique ou intense, cette HC devient délétère et peut conduire à l'insuffisance cardiaque (IC). A l'heure actuelle, notre compréhension des processus impliqués dans le remodelage cardiaque pathologique est incomplète. Dans une première partie de ce travail, nous avons caractérisé une nouvelle protéine cardiaque appelée Carabin dont l'expression est fortement diminuée dans l'HC et l'IC. La délétion génétique de Carabin potentialise l'HC et accélère la transition de l'hypertrophie vers l'IC, dans un modèle murin de surcharge de pression induite par constriction aortique. A l'inverse, la surexpression de Carabin dans le myocarde inhibe le remodelage cardiaque. Les effets anti-hypertrophiques de Carabin sont associés à l'inhibition des petites protéines G Ras et de deux protéines calcium-dépendantes, la CaN et la CaMKII. Dans une deuxième partie, nous nous sommes intéressés à l'implication de Epac1 (Exchange protein directly activated by cAMP 1) dans l'HC induite par les récepteurs béta adrénergiques (béta-ARs). Nos résultats montrent que la délétion de Epac1 améliore la fonction cardiaque et protège du remodelage en réponse à l'activation des béta-ARs. L'une des découvertes majeures de notre étude est que la voie béta-ARs/Epac1 induit l'activation du de l'autophagie in vivo et in vitro via Rap2B/CaMKKbéta/ AMPK afin de freiner les effets hypertrophiques de Epac1. L'ensemble de ce travail a permis d'identifier les rôles et mécanismes d'action de Carabin et Epac1 dans l'HC. Notre étude ouvre de nouvelles pistes thérapeutiques pour le traitement de l'IC
Cardiac hypertrophy is an adaptive mechanism which occurs in response to hemodynamic stress. However, disease-related stresses can promote pathological cardiac hypertrophy and heart failure (HF). At present, our understanding of cardiac hypertrophy and pathological remodeling is still incomplete. In the first part of our study, we characterized Carabin, a protein expressed in cardiomyocytes that was downregulated in cardiac hypertrophy and HF. Four weeks after transverse aortic constriction (TAC), Carabin deficient mice developed exaggerated cardiac hypertrophy and accelerated the transition from hypertrophy to HF. Conversely, cardiac overexpression of Carabin through a gene transfer approach prevented TAC induced cardiac remodeling. Mechanistically, Carabin carries out a tripartite suppressive function. Indeed, Carabin through its Calcineurin (CaN) interacting site and Ras- GAP domain acts as an endogenous inhibitor of Ras and two calcium sensitive proteins, CaN and CaMKII. In the second part, we investigated the role of Epac1 (Exchange protein directly activated by cAMP 1) in béta -adrenergic receptors (béta -ARs)- induced cardiac hypertrophy. Our data showed that Epac1 deletion in mice protected against béta-ARs induced cardiac remodeling and improved cardiac function. Interestingly, béta-ARs-Epac1 activation promoted autophagic activity via Rap2B/CaMKKbéta/AMPK pathway to inhibit Epac1-induced cardiomyocyte hypertrophy. All of this work has identified the roles and mechanisms of action of Carabin and Epac1 in cardiac hypertrophy. Our study opens new therapeutic avenues for the treatment of HF
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Books on the topic "Carabane"

1

Gritten, Virginie. La carabine improvisée. Paris: Chiflet & Cie, 2007.

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La fée carabine. [Paris]: Gallimard, 1987.

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La Fée carabine. [S.l.]: Gallimard, 2004.

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Pennac, Daniel. Hada Carabina. Barcelona: Grijalbo Mondadori, S.A.-Junior, 2000.

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La carabina de Zapata. México D.F: SM, 2004.

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The Marquis of Carabas. Thorndike, Me: Thorndike Press, 1991.

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The Marquis of Carabas. New York: Walker, 1991.

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Hostnig, Rainer. Carabaya: Paisajes y cultura milenaria. Cusco, Perú: R. Hostnig, 2010.

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Domínguez, Carlos María. Tres muescas en mi carabina. Buenos Aires: Alfaguara, 2003.

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Tres muescas en mi carabina. 2nd ed. Montevideo: Alfaguara, 2003.

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Book chapters on the topic "Carabane"

1

Osawa, Syozo, Zhi-Hui Su, and Yûki Imura. "Molecular Phylogeny of the Carabinae." In Molecular Phylogeny and Evolution of Carabid Ground Beetles, 33–89. Tokyo: Springer Japan, 2004. http://dx.doi.org/10.1007/978-4-431-53965-0_5.

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Osawa, Syozo, Zhi-Hui Su, and Yûki Imura. "Formation of the Japanese Carabina Fauna." In Molecular Phylogeny and Evolution of Carabid Ground Beetles, 91–98. Tokyo: Springer Japan, 2004. http://dx.doi.org/10.1007/978-4-431-53965-0_6.

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Osawa, Syozo, Zhi-Hui Su, and Yûki Imura. "Phylogeny and Distribution of the Subfamily Carabinae." In Molecular Phylogeny and Evolution of Carabid Ground Beetles, 25–32. Tokyo: Springer Japan, 2004. http://dx.doi.org/10.1007/978-4-431-53965-0_4.

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Osawa, Syozo, Zhi-Hui Su, and Yûki Imura. "Detailed Exposition of the Japanese Carabina Species." In Molecular Phylogeny and Evolution of Carabid Ground Beetles, 99–139. Tokyo: Springer Japan, 2004. http://dx.doi.org/10.1007/978-4-431-53965-0_7.

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Osawa, Syozo, Zhi-Hui Su, and Yûki Imura. "Phylogeny and Taxonomy: Reorganization of the Subfamily Carabinae Based on Molecular Phylogeny." In Molecular Phylogeny and Evolution of Carabid Ground Beetles, 163–70. Tokyo: Springer Japan, 2004. http://dx.doi.org/10.1007/978-4-431-53965-0_9.

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Persson, Tommy, and Peter Fritzson. "Parallel implementation of image reconstruction for the CARABAS long-wave penetrating radar." In High-Performance Computing and Networking, 327–32. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/3-540-61142-8_566.

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"7. Carabaya." In Las minas hispanoamericanas a mediados del siglo XVIII. Informes enviados al Real Gabinete de Historia Natural de Madrid., 112–24. Vervuert Verlagsgesellschaft, 1989. http://dx.doi.org/10.31819/9783964564375-012.

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Miller, Ivor L. ". From Creole to Carabalí." In Voice of the Leopard, 103–18. University Press of Mississippi, 2009. http://dx.doi.org/10.14325/mississippi/9781934110836.003.0005.

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De Balzac, Honoré. "115. In which Madame Nourrisson is seen at work." In Cousin Bette. Oxford University Press, 2008. http://dx.doi.org/10.1093/owc/9780199553945.003.0116.

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An hour later Montès, Cydalise, and Carabine, back from the Rocher de Cancale, entered Carabine’s little drawing-room in the Rue Saint-Georges. The courtesan saw Madame Nourrisson sitting in an easy-chair by the fire. ‘Why, here’s my good aunt!’ she said. ‘Yes, my child. I’ve come...
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Gorrara, Claire. "Telling Tales: Daniel Pennac, La Fée Carabine (1987)." In The Roman Noir in Post-War French Culture, 90–106. Oxford University Press, 2003. http://dx.doi.org/10.1093/acprof:oso/9780199246090.003.0006.

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Conference papers on the topic "Carabane"

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Walk, Michael A. "Strain/displacement of a carabiner via interferometry." In International Symposium on Optical Science and Technology, edited by Malgorzata Kujawinska, Ryszard J. Pryputniewicz, and Mitsuo Takeda. SPIE, 2000. http://dx.doi.org/10.1117/12.498410.

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Hellsten, Hans, Lars M. Ulander, Anders Gustavsson, and Bjoern Larsson. "Development of VHF CARABAS II SAR." In Aerospace/Defense Sensing and Controls, edited by Gerald S. Ustach. SPIE, 1996. http://dx.doi.org/10.1117/12.243087.

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Alejandro, A. B., J. P. Gonzales, J. P. C. Yap, and N. B. Linsangan. "Grading and sorting of Carabao mangoes using probabilistic neural network." In 4TH ELECTRONIC AND GREEN MATERIALS INTERNATIONAL CONFERENCE 2018 (EGM 2018). Author(s), 2018. http://dx.doi.org/10.1063/1.5080878.

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Novak, Les. "FOPEN change detection experiments using a CARABAS public release data set." In SPIE Defense, Security, and Sensing, edited by Edmund G. Zelnio and Frederick D. Garber. SPIE, 2010. http://dx.doi.org/10.1117/12.855949.

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Ardepolla, Johannie Ave P., Mike Jhon Reymar Cortez, Abigail L. Escorpion, and Jetron J. Adtoon. "Identification and Classification of Export Quality Carabao Mangoes using Image Processing." In ICBRA '19: 2019 6th International Conference on Bioinformatics Research and Applications. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3383783.3383785.

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Ulander, L., A. Gustavsson, J. Fransson, M. Magnusson, G. Smith-Jonforsen, K. Folkesson, B. Hallberg, and L. Eriksson. "Mapping of Wind-Thrown Forests Using the VHF-Band CARABAS-II SAR." In 2006 IEEE International Symposium on Geoscience and Remote Sensing. IEEE, 2006. http://dx.doi.org/10.1109/igarss.2006.944.

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Hallikainen, M., T. Tares, and J. Uusitalo. "Comparison of ERS-2 SAR, HUTSCAT and CARABAS results for boreal forest." In IGARSS '98. Sensing and Managing the Environment. 1998 IEEE International Geoscience and Remote Sensing. Symposium Proceedings. (Cat. No.98CH36174). IEEE, 1998. http://dx.doi.org/10.1109/igarss.1998.702813.

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Hellsten, Hans, Stellan Sahlin, and Patrik Dammert. "Polarimetric subsurface SAR imaging outcome of theoretical development and CARABAS III tests." In 2014 International Radar Conference (Radar). IEEE, 2014. http://dx.doi.org/10.1109/radar.2014.7060256.

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Ulander, Lars M., Per-Olov Froelind, Anders Gustavsson, Hans Hellsten, and Bjoern Larsson. "Detection of concealed ground targets in CARABAS SAR images using change detection." In AeroSense '99, edited by Edmund G. Zelnio. SPIE, 1999. http://dx.doi.org/10.1117/12.357641.

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Henke, Daniel, Arnold Barmettler, and Erich Meier. "Bistatic experiment with the UWB-CARABAS sensor — First results and prospects of future applications." In 2009 IEEE International Geoscience and Remote Sensing Symposium. IEEE, 2009. http://dx.doi.org/10.1109/igarss.2009.5418051.

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