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Dissertations / Theses on the topic 'Carbamazepine'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Webster, Donald Shaw. "Studies of carbamazepine metabolism." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27680.

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The objective of this study was to examine aspects of carbamazepine metabolism, in order to contribute to a long term goal of a thorough examination of how the metabolism of carbamazepine is influenced by other drugs. The first set of experiments were designed with the intent of determining values for the pharmacokinetic parameters of carbamazepine metabolism in male New Zealand white rabbits. Values were obtained for t[sub max] (60-90 min), t[sub ½](90-122 min), clearance (46.2-142.4 ml/min/kg), and the elimination constant (0.0057-0.0077 min⁻¹) in five test cases. In the remainder of cases,

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2

Amore, Benny Michael. "Mechanism of carbamazepine teratogenicity /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/7939.

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3

VASSEUR, ROSINE. "La carbamazepine : indications en psychiatrie." Clermont-Ferrand 1, 1988. http://www.theses.fr/1988CLF11039.

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4

Terra, Luciana Assis 1988. "Avaliação de transformação polimórfica em comprimidos do fármaco carbamazepina por espectroscopia de imagem no infravermelho próximo e ferramentas quimiométricas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249298.

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Orientador: Ronei Jesus Poppi<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-22T20:20:45Z (GMT). No. of bitstreams: 1 Terra_LucianaAssis_M.pdf: 5662002 bytes, checksum: 969f678029bf9ac1f5d8f5fadf9727f9 (MD5) Previous issue date: 2013<br>Resumo: A Espectroscopia de Imagem na região do Infravermelho Próximo juntamente com ferramentas quimiométricas foi utilizada para estudar a transformação polimórfica do fármaco carbamazepina (forma III para forma I) em formulações farmacêuticas do comprimido, geradas por aquecimento.

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5

Marlot, Philippe. "In vitro evaluation of cytotoxicity caused by carbamazepine and its metabolites in association to carbamazepine-induced hypersensitivity reactions." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2025988/.

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Carbamazepine (CBZ), an anticonvulsant and mood-stabilising drug, is known to cause delayed type hypersensitivity reactions. These reactions occur only in a minority of patients treated with the drug, but often result in severe clinical outcomes. Although an association between CBZ-induced hypersensitivity reactions and HLA alleles has been demonstrated, the underlying mechanism(s) of toxicity are poorly understood. Cell death caused by CBZ and one of its metabolites, 9-acridinecarboxaldehyde (9-AC) was investigated. CBZ did not show cytotoxic effects in concentrations ranging from sub-therape

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6

Alfirevic, Ana. "Molecular aspects of carbamazepine-induced hypersensitivity reactions." Thesis, University of Liverpool, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421067.

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7

Wurden, Colleen J. "Metabolism of carbamazepine and inhibitory drug interactions /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/7977.

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8

Martins, Armando Carvalho de Oliveira. "Processo oxidativo avançado UV/H2O2 na oxidação da carbamazepina : avaliação por ensaios respirometricos e ecotoxicologicos." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/257867.

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Orientador: Alexandre Nunes Ponezi<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo<br>Made available in DSpace on 2018-08-13T11:19:54Z (GMT). No. of bitstreams: 1 Martins_ArmandoCarvalhodeOliveira_M.pdf: 1218959 bytes, checksum: 89c4972bf88120caa1add6b7b1eb515a (MD5) Previous issue date: 2009<br>Resumo: O efeito da poluição é resultado inerente da ocupação humana com grande impacto ao ambiente. Um problema atual é a contaminação dos corpos d'água com produtos de origem industrial, agrícola e produtos de origem farmacológic

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9

Panesar, Sukhbinder Kaur. "The effect of carbamazepine on valproic acid metabolism." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26511.

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Modifications to the GCMS assay for valproic acid and 12 metabolites were attempted with respect to internal standards and derivatizing reagents. Four new internal standards, octanoic acid and 2-methylglutaric acid for analysis of VPA and metabolites and hexanoic acid and di-ռ-butylacetic acid for the analysis of hexadeuterated VPA and metabolites were used. Two new derivatizing reagents, MSTFA and MTBSTFA, were tested as alternatives to the reagent previously used. TMS (MSTFA) and tBDMS derivatives were compared with respect to sensitivity, stability, and chromatographic time. The derivative

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10

Yip, V. L. M. "Carbamazepine hypersensitivity : linking metabolism to the immune response." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3002243/.

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Carbamazepine (CBZ) is an effective antiepileptic drug but has been associated with hypersensitivity reactions in up to 10% of patients. These reactions range from mild maculopapular exanthema to life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. The identification of CBZ-specific T cells and strong associations with specific human leukocyte antigen alleles provide evidence for immunological involvement. CBZ is extensively metabolised and forms several reactive metabolites. The aim of this thesis was to investigate the complex relationships between CBZ

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11

OUDRHIRI, JAOUAD. "Lymphome centroblastique et carbamazepine : a propos d'un cas." Toulouse 3, 1990. http://www.theses.fr/1990TOU31034.

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12

Garnier, Jérôme. "Pneumopathie à la carbamazépine : A propos d'un cas et d'une revue de la littérature." Saint-Etienne, 1989. http://www.theses.fr/1989STET6006.

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13

Pinto, Mônia Aparecida Lemos. "Estudos termoanalíticos da carbamazepina: hidratação/desidratação, decomposição térmica e interações com excipientes empregados em formulações farmacêuticas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-01112012-144158/.

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A carbamazepina (5H-dibenz[b, f]azepina-5-carboxamida) é um anticonvulsivante frequentemente utilizado no Brasil e em vários países. Ela apresenta quatro formas polimórficas e um di-hidratado, sendo ativa a Forma III. Entretanto, essa forma é altamente higroscópica podendo converter-se ao di-hidratado, menos ativo biologicamente. Nesse trabalho propõem-se avaliar o comportamento térmico da forma hidratada, visando à recuperação da forma ativa, por aquecimento. Para tanto, foi feito um estudo do comportamento térmico por TG/DTG-DTA e DSC em atmosfera dinâmica de ar e nitrogênio que evidenciou u

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14

Martins, Rodrigo Molina. "Desenvolvimento de dispersões sólidas microparticuladas contendo carbamazepina por spray congealing." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-17112010-112929/.

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O melhoramento das propriedades de dissolução de produtos farmacêuticos é extremamente importante, visto que houve um aumento de fármacos de baixa solubilidade disponibilizados no mercado farmacêutico nos últimos tempos. Várias técnicas têm sido utilizadas para melhorar as propriedades de dissolução destes fármacos como a cominuição, o uso de surfactantes e o preparo de dispersões sólidas. A preparação de dispersões sólidas é um método útil para dispersar moléculas de fármaco em uma matriz sólida hidrofílica. A técnica de spray congealing é usada para produção de micropartículas não necessitan

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15

Elliott, Emma-Claire. "Synthesis and structure-metabolism relationships of halogenated carbamazepine analogues." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569773.

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Adverse drug reactions are a significant burden on industry and healthcare providers. They account for approximately 5 % of hospital admissions and are a considerable cause of morbidity and mortality in patients. While it is widely considered that an individual's susceptibility to idiosyncratic reactions is caused by a variety of factors; ADRs are thought to be linked to the formation and accumulation of reactive drug metabolites rather than the parent drug. Of the patients administered carbamazepine 30-50 % are subject to the development of some form of adverse drug reaction. Carbamazepine is

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16

NAVARRO, CATHERINE. "Effets cardiovasculaires de la carbamazepine : a propos d'un cas." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20136.

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17

Almeida, Ângela Augusta Soares de. "Presence of Carbamazepine in coastal systems : effects on bivalves." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13378.

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Mestrado em Toxicologia e Ecotoxicologia<br>Carbamazepine (CBZ), an antiepileptic drug, is one of the most commonly detected pharmaceutical drugs in aquatic ecosystems, being used as a marker of anthropogenic pollution. Since CBZ is designed to exert a biological effect, when it reaches aquatic environment high probability exists for toxic effects on non-target organisms. In this way, the present study evaluated the acute (96 h) and chronic toxicity (28 d) of environmentally relevant concentrations of CBZ (0.00, 0.03, 0.30, 3.00, 9.00 μg/L) in the edible clams Venerupis decussata (a native s

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18

Green, Victoria Jane. "The role of detoxication enzymes in adverse drug reactions." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283450.

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19

KEBIR, ABDEL-KARIM. "La carbamazepine dans les troubles bipolaires de l'humeur : efficacite, tolerance et role des taux plasmatiques." Toulouse 3, 1989. http://www.theses.fr/1989TOU31122.

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20

Kotcharaksa, Komgrit. "The Mechanisms, Products, and Kinetic of Carbamazepine-Free Chlorine Reactions." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/36422.

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Carbamazepine (CBZ) is an antiepileptic drug widely detected in drinking water supplies and wastewater effluent. It has been previously found that CBZ is recalcitrant to biological removal processes. Therefore, active CBZ will be exposed to wastewater effluent disinfection processes, which for most treatment plants in the United States involves the addition of free chlorine. However, the chlorination mechanisms of CBZ have not been fully investigated and are currently poorly understood. Our experimental studies were conducted to examine the chlorination of CBZ under controlled conditions. The

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21

Lichtenfels, Maike. "Investigation of immunogenetic risk factors for carbamazepine-induced hypersensitivity reactions." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/19333/.

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T-cell mediated hypersensitivity reactions (HSRs) to carbamazepine (CBZ), a commonly used anti-epileptic drug, occur only in a small proportion of patients, but can often be severe in nature. As the underlying pathomechanisms are not fully understood, it has proven difficult to predict who may be at risk of developing CBZ-induced HSRs. Recently, specific human leukocyte antigen (HLA) alleles have been identified as susceptibility factors for CBZ hypersensitivity in diverse populations, indicating that HLA molecules may be functionally involved in CBZ-induced T-cell activation. HLA-A*31:01 repr

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22

García, Martínez Santos Noé. "Field and Laboratory Fish Tissue Accumulation of Carbamazepine and Amiodarone." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc407838/.

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The goals of this dissertation work were to assess the bioaccumulation potential of carbamazepine and amiodarone, two widely used ionizable pharmaceutical compounds that possess mid-range and high LogD values, respectively, and to evaluate alternative methods to assess chemical accumulation in bluntnose minnows, catfish, and tilapia. Results indicated that carbamazepine does not appreciably bioaccumulate in fish tissue with BCFk and BAF carbamazepine values < 10. Amiodarone, however, with a log D of 5.87 at pH 7.4, accumulated in fish tissues with kinetic BCF values <2,400. Collectively, the d

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23

Rathman, Sara C. "Effects of oral carbamazepine administration on biotin metabolism in rats." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001103.

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24

Kfuri, Camila Razuk. "Desenvolvimento de grânulos de carbamazepina por \'hot melt granulation\' em leito fluidizado." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-14102008-094131/.

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Os fármacos pertencentes às classes II e IV do sistema de classificação biofarmacêutica são aqueles sujeitos a problemas relacionados com a sua biodisponibilidade. Um dos procedimentos utilizados para melhorar a solubilidade de fármacos pouco solúveis é a granulação com materiais lipídicos ou cerosos. Para aumentar a solubilidade da carbamazepina, fármaco de classe II, ou seja, que apresenta baixa solubilidade e alta permeabilidade, inicialmente esta foi associada com os excipientes Gelucire® 50/13 ou Polietilenoglicol 6000, através de uma mistura física ou dispersão sólida. Estas associações

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25

Silva, Rita de Cassia da. "\"Preparação e aplicação de eletrodos de pasta de carbono modificados com ditiocarbamatos para análise de fármacos\"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-12042007-100734/.

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O morfolinoditiocarbamato (Mor); o piperidinoditiocarbamato (Pip) e o pirrolidinoditiocarbamato (Pyr) de rutênio derivados respectivamente da morfolina, piperidina e pirrolidina, três aminas alifáticas cíclicas foram preparados e caracterizados por análise elementar, espectroscopia vibracional na região do infravermelho, espectrometria de massa e análise térmica (termogravimetria TG e análise térmica diferencial DTA). A análise elementar mostrou que os compostos de fórmula geral Ru2DTC5.XH2O foram obtidos (DTC = Mor, Pip e Pyr e X = 4, 1,5 e 2 respectivamente); assim como a IV revelou que

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26

Santos, Helder Jacobina. "As Y-glutamil-transferase, transaminases e fosfatases alcalinas séricas em pacientes epilépticos tratados com carbamazepina." reponame:Repositório Institucional da FIOCRUZ, 2005. https://www.arca.fiocruz.br/handle/icict/5905.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-11-29T18:54:35Z No. of bitstreams: 1 Helder Jacobina Santos As y-glutamil... 2005.pdf: 33243351 bytes, checksum: 707639696a2cd425ea90f9fb81248893 (MD5)<br>Made available in DSpace on 2012-11-29T18:54:35Z (GMT). No. of bitstreams: 1 Helder Jacobina Santos As y-glutamil... 2005.pdf: 33243351 bytes, checksum: 707639696a2cd425ea90f9fb81248893 (MD5) Previous issue date: 2005<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>A carbamazepina é a droga de eleição usada no tratamento de

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27

MONAT, THIERRY. "Effets cardiovasculaires des anti-epileptiques : revue de la litterature." Clermont-Ferrand 1, 1989. http://www.theses.fr/1989CLF13046.

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28

PUPESCHI, GERARD. "Criteres de reponse a la carbamazepine dans le syndrome maniaque : etude clinique et biologique." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20136.

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29

Poletti, Jabbour Jamil, Rospigliosi Andrés Wiegering, Elías Reneé Pereyra, and Barrera Carmen Cecilia Elías. "Carbamazepine and oxcarbazepine: reflections after an oxcarbazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap." Springer International Publishing, 2016. http://hdl.handle.net/10757/609483.

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30

Qiu, Shi. "Effects of polymers on carbamazepine cocrystals phase transformation and release profiles." Thesis, De Montfort University, 2015. http://hdl.handle.net/2086/11421.

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The aim of this study is to investigate the effects of coformers and polymers on the phase transformation and release profiles of cocrystals. Pharmaceutical cocrystals of Carbamazepine (CBZ) (namely 1:1 carbamazepine-nicotinamide (CBZ-NIC), 1:1 carbamazepine-saccharin (CBZ-SAC) and 1:1 carbamazepine-cinnamic acid (CBZ-CIN) cocrystals, were synthesized. A Quality by Design (QbD) approach was used to construct the formulation. Dissolution and solubility were studied using UV imaging and High Performance Liquid Chromatography (HPLC). The polymorphic transitions of cocrystals and crystalline prope

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31

Santos, Niedja da Silva. "Chronic effects of carbamazepine on Danio rerio: a multi-parametric evaluation." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/18631.

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Mestrado em Toxicologia e Ecotoxicologia<br>Os fármacos são atualmente considerados contaminantes ambientais emergentes, devido à sua constante deteção nos ecossistemas aquáticos, consequência do aumento na sua produção, diversificação e consumo. A carbamazepina (Cbz) é um fármaco humano utilizado para tratamento de epilepsia, distúrbios bipolares e neuralgia trigeminal estando entre os fármacos mais prescritos no mundo e sendo considerado um marcador de poluição antropogénica. Para uma correta avaliação de risco ambiental é essencial avaliar os efeitos a longo termo dos compostos em vários ní

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32

Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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33

Lee, Jason Tsz Chun. "Prevention of type 1 diabetes by carbamazepine in non-obese diabetic mice." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62704.

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Pancreatic β cells are selectively destroyed by the host immune system in type 1 diabetes, which results in the inability to regulate glucose homeostasis due to loss of insulin production capacity. Drugs that preserve β cell mass and function therefore have the potential to prevent or slow the progression of this disease. It was recently reported by our group that the use-dependent sodium channel blocker, carbamazepine, protects pancreatic β cells from inflammatory cytokines in vitro. Subsequent experiments found carbamazepine increased insulin gene expression, which corroborated with an incre

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34

Makmor, Bakry Mohd. "Influence of genetic variability on the clinical pharmacology of carbamazepine and lamotrigine." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/1778/.

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This research programme investigates the influence of genetic variability on the clinical pharmacology of carbamazepine (CBZ) and lamotrigine (LTG). Common polymorphisms in genes that may influence the response to CBZ and LTG include CYP3A4 g.-392A>G, CYP3A5 g.6986A>G, CYP1A2 g.5734C>A, EPHX1 c.337T>C, EPHX1 c.416A>G, UGT2B7 c.802C>T, ABCB1 c.1236C>T, ABCB1 c.2677G>T/A, ABCB1 c.3435C>T and SCN2A c.56G>A. The prevalence of these common polymorphisms was evaluated in a 400-strong study population from a single research unit. Minor allele frequency ranged between 3.5% (CYP3A4 -392G) and 48.0% (AB

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35

Joshi, Onkar D. "Development of a solvent free continuous co-crystallisation technique for carbamazepine ¿ saccharin." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5697.

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Co-crystals are emerging as a potential area in the field of crystal designing as it improves material¿s physicochemical properties. Many groups are working on the development of newer techniques for the preparation of co-crystals, which can be scalable and contribute to the green agenda. Being continuous and scalable technique, our own developed twin screw extrusion mediated solvent free continuous co-crystallisation (SFCC) technique has been used for the preparation of carbamazepine: saccharin co-crystal. Carbamazepine has been used as a model drug since it shows challenges such as low

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Souza, Beatriz Pacheco de. "Avaliação de alterações cardiovasculares relacionadas ao efeito de drogas antiepilépticas em ratos submetidos ao modelo de indução de epilepsia pela pilocarpina." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8603.

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Tian, Fang, and n/a. "Towards a deeper understanding of the polymorphic conversion of carbamazepine in aqueous suspension." University of Otago. School of Pharmacy, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070601.135438.

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Polymorphism can influence every aspect of the properties of a solid including the shelf life, dissolution rate, solubility, formulation properties and processing properties of a solid drug. A deeper understanding of polymorphism and related solid state properties would ensure an improved quality of the materials used throughout drug preparation, dosage form formulation and clinical trials. Therefore, determination of the existence of polymorphs and pseudopolymorphs, characterization of different solid state forms and their respective properties, and controlling the existing form in the result

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38

Ju, Changqing. "Reactive iminoquinone metabolites of indomethacin and carbamazepine, implications for drug-induced idiosyncratic reactions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0007/NQ41183.pdf.

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39

Wu, Ying. "Characterisation of the cellular basis of hypersensitivity reactions to carbamazepine and para-phenylenediamine." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430894.

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40

Qiao, Ning. "Investigation of carbamazepine-nicotinamide cocrystal solubility and dissolution by a UV imaging system." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/10201.

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In this study, the ability of pharmaceutical cocrystals on improving solubility and dissolution behaviour of poorly water soluble drug has been studied by a novel technique SDI300 UV imaging surface dissolution system. Pharmaceutical cocrystals of poorly water soluble drug carbamazepine (CBZ) were synthesized, which are 1: 1 carbamazepine - nicotinamide (CBZ-NIC) cocrystal, and 2:1 carbamazepine - succinic acid (CBZ-SUC) cocrystal. Firstly, dissolution and solution mediated phase transformation behaviour (SMPT) of CBZ-NIC cocrystal was studied by in situ techniques of UV imaging and Raman spec

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41

Abd, Rahim Syarifah. "Understanding and predicting the physicochemical properties and crystallisation behaviour of carbamazepine co-crystals." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.713468.

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The crystallisation and associated phase composition of carbamazepine (CBZ) co-crystals is presented with respect to the chemical nature of the co-crystal formers. Through an analysis of 50 structures representing three packing motif types, using both experimental and computational modeling, the respective physical properties are reviewed. Using a graded selection approach of increasing complexity, 3 CBZ co-crystals with succinic acid (SCA), aspirin (ASP) and saccharin (SAC) representing each of the known packing motif types are selected and their crystallisation and particulate properties exa

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42

Catala, Isabelle. "Estimation des paramètres pharmacocinétiques de population de la carbamazépine en surveillance thérapeutique hospitalière." Montpellier 1, 1992. http://www.theses.fr/1992MON11103.

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43

BONNETON, VOLPI JOELLE. "Interaction medicamenteuse entre deux antiepileptiques majeurs : la carbamazepine et le valproate de sodium ; etude experimentale et clinique." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX22963.

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Llorca, Pierre-Michel. "Efficacite comparee de la carbamazepine, de la bromocriptine, et de la cyproheptadine en traitement adjuvant aux neuroleptiques chez 24 patients schizophrenes chroniques resistants." Aix-Marseille 2, 1991. http://www.theses.fr/1991AIX20953.

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Zheng, Thomas Wen-Juan. "Neurophysiological and pharmacological study of carbamazepine on physiological and pathological GABAergic-dependent thalamocortical oscillations." Strasbourg, 2010. http://www.theses.fr/2010STRA6131.

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La CBZ est un anticonvulsivant largement prescrit, utilisé dans le traitement des épilepsies focales et de troubles psychiatriques. Cependant, il est connu que son large spectre d'action sur différentes cibles moléculaires contribue à des effets secondaires communs et sévères. La CBZ interagit directement avec les récepteurs GABAA, qui jouent un rôle critique dans l’électrogenèse d’oscillations TC/CT physiologiques et pathologiques. Mon travail de thèse offre des arguments solides pour dire que la CBZ module les propriétés de décharge et d’oscillations des neurones thalamiques, au moins dans l

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Sampaio, Mariana Neiva. "The role of personality in fish response to Carbamazepine: from biochemical responses to learning." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22022.

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Mestrado em Biologia Molecular e Celular<br>A personalidade animal está ligada aos processos fisiológicos e bioquímicos do organismo. É definida como um conjunto individual de padrões comportamentais que se mantêm ao longo de um determinado período de vida. Estudos recentes mostraram a capacidade de muitos compostos, incluindo fármacos, interferirem no comportamento e em traços da personalidade. No entanto, o conhecimento sobre este fenómeno é ainda limitado. Sabendo-se que os fármacos podem interferir na personalidade, coloca-se a questão: qual será o papel da personalidade no efeito dos fárm

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Sauvêtré, Andrés. "Uptake and metabolism of the antiepileptic drug carbamazepine in plants and role of endophytic bacteria." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/456572.

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Nuestro medio ambiente y reservas de agua reciben cada vez más productos de cuidado personal y fármacos. A pesar de una parcial degradación, algunos de estos compuestos presentan una eficiencia de eliminación muy baja en plantas convencionales de tratamiento de aguas residuales. En este contexto, el fármaco antiepiléptico carbamazepina (CBZ) es uno de los más recalcitrantes. Este producto se halla frecuentemente en aguas residuales, e incluso en los efluentes de las plantas de tratamiento de aguas residuales después del proceso de purificación, llegando a aguas superficiales y, en algunos caso

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Timsit, Yoav Ephraim. "Characterization of anti-cytochrome P450 antibodies in patients with carbamazepine hypersensitivity reactions, a mechanistic study." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29331.pdf.

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Bridgens, Rosalie Anne. "The role of counselling, monitoring of serum carbamazepine concentration, and of compliance in epilepsy control." Thesis, University of Limpopo (Medunsa Campus), 2012. http://hdl.handle.net/10386/1079.

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Thesis (MSc(Med)(Pharmacy))-- University of Limpopo, 2012.<br>i THE ROLE OF COUNSELLING, MONITORING OF SERUM CARBAMAZEPINE CONCENTRATION, AND OF COMPLIANCE IN EPILEPSY CONTROL Non-compliance with the patient’s prescribed medication regimen has been identified in several publications as a major factor responsible for insufficient seizure control. Non-compliance is also held by some workers in this field to be closely interlinked with inadequate serum anti-epileptic drug concentration. The early identification of non-compliance may therefore play an important role in epilepsy therapy.

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Galvão, Wilma Gomes. "CARBAMAZEPINA NO ESTADO SÓLIDO E SUA SUSCEPTIBILIDADE POLIMÓRFICA." Pontifícia Universidade Católica de Goiás, 2009. http://localhost:8080/tede/handle/tede/2115.

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Made available in DSpace on 2016-08-10T10:29:34Z (GMT). No. of bitstreams: 1 Wilma Gomes Galvao.pdf: 1683869 bytes, checksum: fab2810f336fcca017df31d20e4619cc (MD5) Previous issue date: 2009-06-25<br>Many pharmaceutical products are in solid state for reasons of stability or ease of handling during the stages of drug development. The polymorphism is the crystallization of the same substance in different crystalline architectures. This phenomenon is very common in pharmaceuticals and is associated with differences in packing arrangements of crystalline. The presence of different crystalline f

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