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Journal articles on the topic 'Carbamoyl radicals'

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1

Safiulina, A. M., A. V. Lizunov, E. I. Goryunov, et al. "Derivatives of (2-carbamoyl ethyl)diphenylphosphine oxides: synthesis and extraction properties with respect to actinides and lanthanides." Журнал неорганической химии 69, no. 1 (2024): 99–109. http://dx.doi.org/10.31857/s0044457x24010124.

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A series of (2–carbamoyl ethyl)diphenylphosphine oxides (KFO) has been synthesized from commercially available reagents — diphenyl chlorophosphine and acrylamides. The influence of the number of ligand fragments of Ph2P(O)(CH2)2C(O), the nature of the oligoyl radical binding these fragments, as well as the presence of additional coordination centers in the KEFO molecule on the extraction properties of KEFO with respect to actinides and lanthanides was investigated. It was found that N,N′-methylene-bis[3-(diphenylphosphoryl) has the greatest efficiency in the extraction of actinidespropionamide
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2

Raviola, Carlotta, Stefano Protti, Davide Ravelli, and Maurizio Fagnoni. "Photogenerated acyl/alkoxycarbonyl/carbamoyl radicals for sustainable synthesis." Green Chemistry 21, no. 4 (2019): 748–64. http://dx.doi.org/10.1039/c8gc03810d.

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3

Xie, Long-Yong, Sha Peng, Li-Hua Yang, and Xiao-Wen Liu. "Metal-Free Synthesis of Carbamoylated Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)arylaldehydes with Oxamic Acids." Molecules 27, no. 20 (2022): 7049. http://dx.doi.org/10.3390/molecules27207049.

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An efficient and straightforward approach for the synthesis of carbamoylated chroman-4-ones has been well-developed. The reaction is triggered through the generation of carbamoyl radicals from oxamic acids under metal-free conditions, which subsequently undergoes decarboxylative radical cascade cyclization on 2-(allyloxy)arylaldehydes to afford various amide-containing chroman-4-one scaffolds with high functional group tolerance and a broad substrate scope.
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4

de Pedro Beato, Eduardo, Daniele Mazzarella, Matteo Balletti, and Paolo Melchiorre. "Photochemical generation of acyl and carbamoyl radicals using a nucleophilic organic catalyst: applications and mechanism thereof." Chemical Science 11, no. 24 (2020): 6312–24. http://dx.doi.org/10.1039/d0sc02313b.

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An organic catalyst uses low-energy photons to generate acyl and carbamoyl radicals upon activation of the corresponding chlorides via a nucleophilic acyl substitution path. The synthetic potential and the mechanism of this strategy are discussed.
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5

Osmanoğlua, Şemsettin, Murat Aydın, and M. Halim Başkana. "EPR of Gamma-irradiated L-Glutamine Hydrochloride and N-Carbamoyl-L-glutamic Acid." Zeitschrift für Naturforschung A 60, no. 7 (2005): 549–53. http://dx.doi.org/10.1515/zna-2005-0715.

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The electron paramagnetic resonance spectra of γ -irradiated L-glutamine hydrochloride and N-carbamoyl- L-glutamic acid single crystals have been investigated at room temperature. Radiation damage centres are attributed to ĊH, ṄH2 and CH2Ċ(NH2)COOH radicals.
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6

Rigby, James H., Diana M. Danca, and John H. Horner. "Carbamoyl radicals from Se-phenylselenocarbamates: Intramolecular additions to alkenes." Tetrahedron Letters 39, no. 46 (1998): 8413–16. http://dx.doi.org/10.1016/s0040-4039(98)01830-9.

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7

Song, Liyan, Xinqiang Fang, Zijia Wang, Kun Liu та Chaozhong Li. "Stereoselectivity of 6-Exo Cyclization of α-Carbamoyl Radicals". Journal of Organic Chemistry 81, № 6 (2016): 2442–50. http://dx.doi.org/10.1021/acs.joc.6b00008.

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8

Song, Liyan, Kun Liu та Chaozhong Li. "Efficient and Regioselective 9-EndoCyclization of α-Carbamoyl Radicals". Organic Letters 13, № 13 (2011): 3434–37. http://dx.doi.org/10.1021/ol201180g.

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9

Minisci, Francesco, Fausta Coppa, and Francesca Fontana. "Reactivity of carbamoyl radicals: the first general and convenient free-radical synthesis of isocyanates." Journal of the Chemical Society, Chemical Communications, no. 6 (1994): 679. http://dx.doi.org/10.1039/c39940000679.

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10

Koshiishi, Ichiro, Kazunori Tsuchida, Tokuko Takajo, and Makiko Komatsu. "Radical scavenger can scavenge lipid allyl radicals complexed with lipoxygenase at lower oxygen content." Biochemical Journal 395, no. 2 (2006): 303–9. http://dx.doi.org/10.1042/bj20051595.

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Lipoxygenases have been proposed to be a possible factor that is responsible for the pathology of certain diseases, including ischaemic injury. In the peroxidation process of linoleic acid by lipoxygenase, the E,Z-linoleate allyl radical–lipoxygenase complex seems to be generated as an intermediate. In the present study, we evaluated whether E,Z-linoleate allyl radicals on the enzyme are scavenged by radical scavengers. Linoleic acid, the content of which was greater than the dissolved oxygen content, was treated with soya bean lipoxygenase-1 (ferric form) in the presence of radical scavenger,
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11

Panagopoulos, Anastasios, Konstantina Alipranti, Kyriaki Mylona, et al. "Exploration of the DNA Photocleavage Activity of O-Halo-phenyl Carbamoyl Amidoximes: Studies of the UVA-Induced Effects on a Major Crop Pest, the Whitefly Bemisia tabaci." DNA 3, no. 2 (2023): 85–100. http://dx.doi.org/10.3390/dna3020006.

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The DNA photocleavage effect of halogenated O-carbamoyl derivatives of 4-MeO-benzamidoxime under UVB and UVA irradiation was studied in order to identify the nature, position, and number of halogens on the carbamoyl moiety that ensure photoactivity. F, Cl, and Br-phenyl carbamate esters (PCME) exhibited activity with the p-Cl-phenyl derivative to show excellent photocleavage against pBR322 plasmid DNA. m-Cl-PCME has diminished activity, whereas the presence of two halogen atoms reduced DNA photocleavage. The substitution on the benzamidoxime scaffold was irrelevant to the activity. The mechani
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12

López-Valdez, Germán, Simón Olguín-Uribe, and Luis D. Miranda. "Carbamoyl radicals from carbamoylxanthates: a facile entry into isoindolin-1-ones." Tetrahedron Letters 48, no. 47 (2007): 8285–89. http://dx.doi.org/10.1016/j.tetlet.2007.09.142.

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13

RIGBY, J. H., D. M. DANCA, and J. H. HORNER. "ChemInform Abstract: Carbamoyl Radicals from Se-Phenylselenocarbamates: Intramolecular Additions to Alkenes." ChemInform 30, no. 6 (2010): no. http://dx.doi.org/10.1002/chin.199906150.

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14

MINISCI, F., F. COPPA, and F. FONTANA. "ChemInform Abstract: Reactivity of Carbamoyl Radicals: The First General and Convenient Free-Radical Synthesis of Isocyanates." ChemInform 25, no. 31 (2010): no. http://dx.doi.org/10.1002/chin.199431121.

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15

Assayag, Miri, Sara Goldstein, Amram Samuni, and Neville Berkman. "3-Carbamoyl-proxyl nitroxide radicals attenuate bleomycin-induced pulmonary fibrosis in mice." Free Radical Biology and Medicine 171 (August 2021): 135–42. http://dx.doi.org/10.1016/j.freeradbiomed.2021.05.010.

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16

Song, Liyan, Kun Liu та Chaozhong Li. "ChemInform Abstract: Efficient and Regioselective 9-endo Cyclization of α-Carbamoyl Radicals." ChemInform 42, № 45 (2011): no. http://dx.doi.org/10.1002/chin.201145167.

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17

Grainger, Richard S., and Paolo Innocenti. "Dithiocarbamate Group Transfer Cyclization Reactions of Carbamoyl Radicals under “Tin-Free” Conditions." Angewandte Chemie International Edition 43, no. 26 (2004): 3445–48. http://dx.doi.org/10.1002/anie.200453600.

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18

Grainger, Richard S., and Paolo Innocenti. "Dithiocarbamate Group Transfer Cyclization Reactions of Carbamoyl Radicals under“Tin-Free” Conditions." Angewandte Chemie 116, no. 26 (2004): 3527–30. http://dx.doi.org/10.1002/ange.200453600.

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19

Cardinale, Luana, Mikhail O. Konev, and Axel Jacobi von Wangelin. "Photoredox‐Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4‐Dihydropyridine Approach." Chemistry – A European Journal 26, no. 37 (2020): 8239–43. http://dx.doi.org/10.1002/chem.202002410.

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20

Franco Bella, A., Leon V. Jackson та John C. Walton. "Preparation of β-and γ-lactams via ring closures of unsaturated carbamoyl radicals derived from 1-carbamoyl-1-methylcyclohexa-2,5-dienes". Org. Biomol. Chem. 2, № 3 (2004): 421–28. http://dx.doi.org/10.1039/b313932h.

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21

Minisci, Francesco, Francesca Fontana, Fausta Coppa, and Yong Ming Yan. "Reactivity of Carbamoyl Radicals. A New, General, Convenient Free-Radical Synthesis of Isocyanates from Monoamides of Oxalic Acid." Journal of Organic Chemistry 60, no. 17 (1995): 5430–33. http://dx.doi.org/10.1021/jo00122a020.

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22

Scanlan, Eoin M., Alexandra M. Z. Slawin та John C. Walton. "Preparation of β- and γ-lactams from carbamoyl radicals derived from oxime oxalate amides". Org. Biomol. Chem. 2, № 5 (2004): 716–24. http://dx.doi.org/10.1039/b315223e.

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23

Kovacic, Peter. "Hydroxyurea (therapeutics and mechanism): Metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications." Medical Hypotheses 76, no. 1 (2011): 24–31. http://dx.doi.org/10.1016/j.mehy.2010.08.023.

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24

MINISCI, F., F. FONTANA, F. COPPA, and Y. M. YAN. "ChemInform Abstract: Reactivity of Carbamoyl Radicals. A New, General, Convenient Free- Radical Synthesis of Isocyanates from Monoamides of Oxalic Acid." ChemInform 27, no. 1 (2010): no. http://dx.doi.org/10.1002/chin.199601091.

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25

Fang, Xinqiang, Kun Liu та Chaozhong Li. "Efficient Regio- and Stereoselective Formation of Azocan-2-ones via 8-EndoCyclization of α-Carbamoyl Radicals". Journal of the American Chemical Society 132, № 7 (2010): 2274–83. http://dx.doi.org/10.1021/ja9082649.

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26

Fujiwara, Shin-ichi, Yoshihiko Shimizu, Yuji Imahori, Masashi Toyofuku, Tsutomu Shin-ike та Nobuaki Kambe. "A new entry to α-alkylidene-β-lactams by 4-exo-dig cyclization of carbamoyl radicals". Tetrahedron Letters 50, № 26 (2009): 3628–30. http://dx.doi.org/10.1016/j.tetlet.2009.03.071.

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27

DiLabio, Gino A., Eoin M. Scanlan, and John C. Walton. "Kinetic and Theoretical Study of 4-exoRing Closures of Carbamoyl Radicals onto CC and CN Bonds." Organic Letters 7, no. 1 (2005): 155–58. http://dx.doi.org/10.1021/ol047716+.

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28

Benati, Luisa, Giorgio Bencivenni, Rino Leardini, et al. "Generation and Cyclization of Unsaturated Carbamoyl Radicals Derived fromS-4-Pentynyl Carbamothioates under Tin-Free Conditions." Journal of Organic Chemistry 71, no. 8 (2006): 3192–97. http://dx.doi.org/10.1021/jo0602064.

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29

Liu, Li, Qian Chen, Yun-Dong Wu та Chaozhong Li. "8-Endo versus 7-Exo Cyclization of α-Carbamoyl Radicals. A Combination of Experimental and Theoretical Studies". Journal of Organic Chemistry 70, № 5 (2005): 1539–44. http://dx.doi.org/10.1021/jo0481349.

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30

Quirante, Josefina, Carmen Escolano, Laura Costejà, and Josep Bonjoch. "Cyclization of 1-(carbamoyl)dichloromethyl radicals upon activated alkenes. A new entry to 2-azabicyclo[3.3.1]nonanes." Tetrahedron Letters 38, no. 39 (1997): 6901–4. http://dx.doi.org/10.1016/s0040-4039(97)01590-6.

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31

Francisco, Cosme G., Antonio J. Herrera, Ángeles Martín, Inés Pérez-Martín, and Ernesto Suárez. "Intramolecular 1,5-hydrogen atom transfer reaction promoted by phosphoramidyl and carbamoyl radicals: synthesis of 2-amino-C-glycosides." Tetrahedron Letters 48, no. 36 (2007): 6384–88. http://dx.doi.org/10.1016/j.tetlet.2007.06.152.

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32

Bai, Qi-Fan, Chengan Jin, Jing-Yao He, and Gaofeng Feng. "Carbamoyl Radicals via Photoredox Decarboxylation of Oxamic Acids in Aqueous Media: Access to 3,4-Dihydroquinolin-2(1H)-ones." Organic Letters 20, no. 8 (2018): 2172–75. http://dx.doi.org/10.1021/acs.orglett.8b00449.

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33

Midorikawa, Kaoru, Kazutaka Hirakawa, and Shosuke Kawanishi. "Hydroxylation of Deoxyguanosine at 5′ Site of GG and GGG Sequences in Double-stranded DNA Induced by Carbamoyl Radicals." Free Radical Research 36, no. 6 (2002): 667–75. http://dx.doi.org/10.1080/10715760290029119.

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34

QUIRANTE, J., C. ESCOLANO, L. COSTEJA, and J. BONJOCH. "ChemInform Abstract: Cyclization of 1-(Carbamoyl)dichloromethyl Radicals Upon Activated Alkenes. A New Entry to 2-Azabicyclo(3.3.1)nonanes." ChemInform 28, no. 52 (2010): no. http://dx.doi.org/10.1002/chin.199752176.

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35

Gill, G. Bryon, Gerald Pattenden, and Stephen J. Reynolds. "Cobalt-mediated reactions: inter- and intra-molecular additions of carbamoyl radicals to alkenes in the synthesis of amides and lactams." Journal of the Chemical Society, Perkin Transactions 1, no. 4 (1994): 369. http://dx.doi.org/10.1039/p19940000369.

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36

Camarillo-López, Raúl Horacio, Maricarmen Hernández Rodríguez, Mónica Adriana Torres-Ramos, et al. "Tert-butyl-(4-hydroxy-3-((3-(2-methylpiperidin-yl)propyl)carbamoyl)phenyl)carbamate Has Moderated Protective Activity in Astrocytes Stimulated with Amyloid Beta 1-42 and in a Scopolamine Model." Molecules 25, no. 21 (2020): 5009. http://dx.doi.org/10.3390/molecules25215009.

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Alzheimer’s disease (AD) is a neurodegenerative disease with no cure nowadays; there is no treatment either to prevent or to stop its progression. In vitro studies suggested that tert-butyl-(4-hydroxy-3-((3-(2-methylpiperidin-yl)propyl)carbamoyl)phenyl) carbamate named the M4 compound can act as both β-secretase and an acetylcholinesterase inhibitor, preventing the amyloid beta peptide (Aβ) aggregation and the formation of fibrils (fAβ) from Aβ1-42. This work first aimed to assess in in vitro studies to see whether the death of astrocyte cells promoted by Aβ1-42 could be prevented. Second, our
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37

Vlad, Ilinca Margareta, Diana Camelia Nuță, Robert Viorel Ancuceanu, et al. "Insights into the Microbicidal, Antibiofilm, Antioxidant and Toxicity Profile of New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives." International Journal of Molecular Sciences 24, no. 8 (2023): 7020. http://dx.doi.org/10.3390/ijms24087020.

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The unprecedented increase in microbial resistance rates to all current drugs raises an acute need for the design of more effective antimicrobial strategies. Moreover, the importance of oxidative stress due to chronic inflammation in infections with resistant bacteria represents a key factor for the development of new antibacterial agents with potential antioxidant effects. Thus, the purpose of this study was to bioevaluate new O-aryl-carbamoyl-oxymino-fluorene derivatives for their potential use against infectious diseases. With this aim, their antimicrobial effect was evaluated using quantit
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38

GILL, G. B., G. PATTENDEN, and S. J. REYNOLDS. "ChemInform Abstract: Cobalt-Mediated Reactions: Inter- and Intramolecular Additions of Carbamoyl Radicals to Alkenes in the Synthesis of Amides and Lactams." ChemInform 25, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.199424092.

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39

Jackson, Leon V., та John C. Walton. "Generation of aminoacyl radicals from 1-carbamoyl-1-methylcyclohexa-2,5- dienes: a new tin-free homolytic route to β- and γ-lactams". Chemical Communications, № 23 (2000): 2327–28. http://dx.doi.org/10.1039/b007454n.

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40

Komatsu, Makiko, and Midori Hiramatsu. "Change of nitroxide radicals in the live rat head of senescence accelerated mice (SAM-P/8) after intraperitoneal injection of carbamoyl-proxyl." Neuroscience Research Supplements 19 (January 1994): S170. http://dx.doi.org/10.1016/0921-8696(94)92745-6.

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41

Zincircioğlu, S. Burhanedtin, Naime Canoruç, Şemsettin Osmanoğlu, M. Halim Başkan, I. Yeşim Dicle та Murat Aydın. "Electron Paramagnetic Resonance of Some γ-Irradiated Amino Acid Derivatives". Zeitschrift für Naturforschung A 61, № 10-11 (2006): 577–82. http://dx.doi.org/10.1515/zna-2006-10-1110.

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γ -Irradiated powders of N-acetyl-L-arginine, Nα -carbamyl-L-arginine, N-glycyl-L-leucine and glycyl-L-alanine were investigated at room temperature by electron paramagnetic resonance. The observed species in N-acetyl-L-arginine and Nα -carbamyl-L-arginine were attributed to the CH2CHNHCNHNH2 radical, and those in N-glycyl-L-leucine and glycyl-L-alanine powders to (CH3)2CCH2 and CH3CHCOOH radicals.
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42

Jackson, Leon V., та John C. Walton. "ChemInform Abstract: Generation of Aminoacyl Radicals from 1-Carbamoyl-1-methylcyclohexa-2,5-dienes: A New Tin-Free Homolytic Route to β- and γ-Lactams." ChemInform 32, № 14 (2001): no. http://dx.doi.org/10.1002/chin.200114050.

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43

Franco Bella, A., Leon V. Jackson, and John C. Walton. "A kinetic EPR study of the dissociation of 1-carbamoyl-1-methylcyclohexa-2,5-dienyl radicals: release of aminoacyl radicals and their cyclisationElectronic supplementary information (ESI) available: Selected EPR spectra, measured radical concentrations and the corresponding rate constants at each temperature for each cyclohexadienyl. AM1 computed heats of formation and selected geometric parameters for a series of cyclohexadienyl radicals and dissociation products. UB3LYP computed energies for model aminoacyl radicals. See http://www.rsc.org/suppdata/p2/b2/b206768d/." Journal of the Chemical Society, Perkin Transactions 2, no. 11 (October 8, 2002): 1839–43. http://dx.doi.org/10.1039/b206768d.

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44

Tang, Jia-Jun, Meng-Yang Zhao, Ying-Jun Lin, Li-Hua Yang, and Long-Yong Xie. "Persulfate-Promoted Carbamoylation/Cyclization of Alkenes: Synthesis of Amide-Containing Quinazolinones." Molecules 29, no. 5 (2024): 997. http://dx.doi.org/10.3390/molecules29050997.

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The incorporation of amide groups into biologically active molecules has been proven to be an efficient strategy for drug design and discovery. In this study, we present a simple and practical method for the synthesis of amide-containing quinazolin-4(3H)-ones under transition-metal-free conditions. This is achieved through a carbamoyl-radical-triggered cascade cyclization of N3-alkenyl-tethered quinazolinones. Notably, the carbamoyl radical is generated in situ from the oxidative decarboxylative process of oxamic acids in the presence of (NH4)2S2O8.
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45

Grossi, Loris. "N-alkyl and N-aryl-carbamoly radicals: a new σ-type radical". J. Chem. Soc., Chem. Commun., № 17 (1989): 1248–50. http://dx.doi.org/10.1039/c39890001248.

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46

Petersen, Wade F., Richard J. K. Taylor, and James R. Donald. "Photoredox-catalyzed procedure for carbamoyl radical generation: 3,4-dihydroquinolin-2-one and quinolin-2-one synthesis." Organic & Biomolecular Chemistry 15, no. 27 (2017): 5831–45. http://dx.doi.org/10.1039/c7ob01274h.

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47

Osmanoğlu, Şemsettin, та M. Halim Başkan. "Electron Paramagnetic Resonance of Gamma Irradiation Damage Centres in Acetyl and Carbamyl-β-Methyl Choline Chloride". Journal of Chemical Research 2003, № 1 (2003): 26–27. http://dx.doi.org/10.3184/030823403103172814.

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The EPR spectra of 7-irradiated powders of acetyl-β-methyl choline chloride (AβMCCl) and carbamyl-β-methyl choline chloride (CβMCCl) indicated the existence of the [Me3NĊMeCH2OCOMe]Cl radical in the former and of the [Me3NĊMeCH2OCONH2]Cl radical in the latter.
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48

Millán-Ortiz, Alejandra, German López-Valdez, Fernando Cortez-Guzmán, and Luis D. Miranda. "A novel carbamoyl radical based dearomatizing spiroacylation process." Chemical Communications 51, no. 39 (2015): 8345–48. http://dx.doi.org/10.1039/c4cc06192f.

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49

Jatoi, Ashique Hussain, Govind Goroba Pawar, Frédéric Robert, and Yannick Landais. "Visible-light mediated carbamoyl radical addition to heteroarenes." Chemical Communications 55, no. 4 (2019): 466–69. http://dx.doi.org/10.1039/c8cc08326f.

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50

Wei, Rongbiao, Liang Ge, Hongli Bao, Saihu Liao, and Yajun Li. "Copper-Catalyzed Nitrogenation of Aromatic and Aliphatic Aldehydes: A Direct Route to Carbamoyl Azides." Synthesis 51, no. 24 (2019): 4645–49. http://dx.doi.org/10.1055/s-0039-1690683.

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An efficient copper-catalyzed synthesis of carbamoyl azides directly from aldehydes has been developed. Both aromatic aldehydes and aliphatic aldehydes, together with other commercially available reactants, can be used as substrates in this radical relay reaction. Broad substrate scope, simple operation, readily available reagents, and good functionality tolerance make this method very attractive.
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