Academic literature on the topic 'Carbocycle'

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Journal articles on the topic "Carbocycle"

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Xie, Xiu-Ying, Wei-Tao Jiang, and Bin Xiao. "Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy." Synthesis 53, no. 16 (May 18, 2021): 2819–27. http://dx.doi.org/10.1055/s-0040-1720693.

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Synthesis of seven-membered carbocycle-fused aromatics was realized by Catellani reaction using terminally brominated alkyl carbagermatranes through intermolecular cyclization manner. Various functional groups were well tolerated, and this transformation was also expanded to the synthesis of carbocycles of other size. The utility of this method was demonstrated by modification of natural product derivatives and synthesis of bioactive molecules.
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Aimon, Anthony, Louis J. Farrugia, and J. Stephen Clark. "Synthesis of the Core Framework of the Cornexistins by Intramolecular Nozaki-Hiyama-Kishi Coupling." Molecules 24, no. 14 (July 22, 2019): 2654. http://dx.doi.org/10.3390/molecules24142654.

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A new and direct approach to the construction of the core framework of the herbicidal natural products cornexistin and hydroxycornexistin has been developed. Formation of the nine-membered carbocycle found in the natural products has been accomplished by an intramolecular Nozaki-Hiyama-Kishi reaction between a vinylic iodide and an aldehyde. Good yields of carbocyclic products were obtained from the reaction, but diastereomeric mixtures of allylic alcohols were produced. The cyclisation reaction was successful irrespective of the relative configuration of the stereogenic centres in the cyclisation precursor.
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Wang, Zhuo, and Junyang Liu. "All-carbon [3 + 2] cycloaddition in natural product synthesis." Beilstein Journal of Organic Chemistry 16 (December 9, 2020): 3015–31. http://dx.doi.org/10.3762/bjoc.16.251.

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Many natural products possess interesting medicinal properties that arise from their intriguing chemical structures. The highly-substituted carbocycle is one of the most common structural features in many structurally complicated natural products. However, the construction of highly-substituted, stereo-congested, five-membered carbocycles containing all-carbon quaternary center(s) is, at present, a distinct challenge in modern synthetic chemistry, which can be accessed through the all-carbon [3 + 2] cycloaddition. More importantly, the all-carbon [3 + 2] cycloaddition can forge vicinal all-carbon quaternary centers in a single step and has been demonstrated in the synthesis of complex natural products. In this review, we present the development of all-carbon [3 + 2] cycloadditions and illustrate their application in natural product synthesis reported in the last decade covering 2011–2020 (inclusive).
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Navaratne, Primali V., and Alexander J. Grenning. "Deconjugative alkylation/Heck reaction as a simple platform for dihydronaphthalene synthesis." Organic & Biomolecular Chemistry 15, no. 1 (2017): 69–75. http://dx.doi.org/10.1039/c6ob02250b.

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Han, Lingli, and Tao Liu. "A theoretical study on the palladium-catalyzed oxidative carbocyclization–alkoxycarbonylation of bisallenes to construct seven-membered carbocycles assisted by olefins." Organic & Biomolecular Chemistry 15, no. 23 (2017): 5055–61. http://dx.doi.org/10.1039/c7ob01161j.

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Tsukamoto, Hirokazu, Ayumu Kawase, and Takayuki Doi. "Asymmetric palladium-catalyzed umpolung cyclization of allylic acetate-aldehyde using formate as a reductant." Chemical Communications 51, no. 38 (2015): 8027–30. http://dx.doi.org/10.1039/c5cc02176f.

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Asymmetic palladium/chiral diphosphine-catalyzed umpolung cyclization of allylic acetate-aldehyde using formate as a reductant affordscis-disubstituted pyrrolidine, tetrahydrofuran, and spiro carbocycle.
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Abboud, K. A., E. J. Enholm, and A. Trivellas. "Structure of a densely oxygenated carbocycle." Acta Crystallographica Section C Crystal Structure Communications 48, no. 2 (February 15, 1992): 370–72. http://dx.doi.org/10.1107/s0108270191008879.

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Abboud, K. A., E. J. Enholm, and A. Trivellas. "Structure of a densely oxygenated carbocycle." Acta Crystallographica Section C Crystal Structure Communications 48, no. 9 (September 15, 1992): 1695–98. http://dx.doi.org/10.1107/s0108270192001033.

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Larock, Richard C., Qingping Tian, and Alexandre A. Pletnev. "Carbocycle Synthesis via Carbopalladation of Nitriles." Journal of the American Chemical Society 121, no. 13 (April 1999): 3238–39. http://dx.doi.org/10.1021/ja984086w.

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Desenko, S. M., K. �strada, V. D. Orlov, and O. A. Ponomarev. "Carbocycle annelated 1,2,4-triazolo[1,5-?]pyrimidines." Chemistry of Heterocyclic Compounds 27, no. 1 (January 1991): 88–91. http://dx.doi.org/10.1007/bf00633226.

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Dissertations / Theses on the topic "Carbocycle"

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Marrison, Shaun. "Development of new radical cyclisation methodologies for carbocycle synthesis." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247637.

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Istrate, Florin-Marian. "Development of new transformations catalyzed by gold(I) complexes." Palaiseau, Ecole polytechnique, 2009. http://pastel.paristech.org/5595/01/Florin_Marian_ISTRATE_-_Ph.D._Manuscript.pdf.

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Dans les dernières années, les complexes d'or se sont avérés des excellents catalyseurs pour des nombreuses transformations homogènes impliquant l'activation des liaisons carbon-carbon multiples vis-à-vis de l'attaque des différents nucléophiles (Chapitre 1). Suite à la découverte par le Dr. Fabien L. Gagosz d'une nouvelle classe de catalyseurs cationiques d'or(I), cristallins, stables à l'air et très réactifs, ayant un groupement triflimide comme contre-anion (Chapitre 2), notre équipe s'est intéressée au développement de nouvelles transformations catalysées par ces complexes. Ce manuscrit présente une partie du travail effectué dans ce domaine qui a mené à la découverte de nouvelles méthodes pour la synthèse des différents dérivés hétéro- et carbocycliques, tels que les 4-alkylidène-1,3-dioxolan-2-ones (Chapitre 3), les 4-oxazolin-2-ones (Chapitre 4), les 2,5-dihydrofuranes (Chapitre 5), les pyrroles et les furanes (Chapitre 6), les esters de 1,3-butadièn-2-ol (Chapitre 7), les cyclopentènes (Chapitre 8) ou bien les 1,3-oxazinan-2-ones (Chapitre 9)
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Chambournier, Gilles. "Part I : Free radical cyclizations for carbocycle synthesis ;bPart II : diastereoselective synthesis of an enantiopure perhydroindole /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487951214941124.

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Phun, Lien Hoang. "Innovative approaches to carbocyclic and heterocyclic compounds using strained carbocycles." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47542.

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Natural products and small molecules play a major role in drug development. However, using natural products as a source of medicine comes with many challenges, such as lack of natural abundance and difficulty in isolation. Consequently, synthetic organic chemistry is a solution in order to access these compounds in usable quantities. However, synthetic chemisty comes with its own challenges such as efficiency, chemoselectivity, stereoselectivity and enantioselectivity. Therefore, synthetic tools that addresses these challenges are required solve these limitations. This thesis discusses new methodologies using strained carbocycles (cyclopropanes and cyclopropenes) as the reactive subunit for the construction of different carbocyclic and heterocyclic compounds. The homo-Nazarov cyclization of alkenyl and heteroaryl cyclopropyl ketones was used in order to construct cyclohexenones, cyclohexenols, heteroaryl ring-fused cyclohexenones, dihydrofurans, furans and furanones in a mild and efficient manner. Benzofused heteroaromatic compounds were achieved via the Lewis acid-catalyzed cycloisomerization of cyclopropene-3,3-dicarbonyls and furan-3-carboxylates. These heteroaromatic compounds can be applied to medicinal chemistry and material science.
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Haraguchi, Ryosuke. "Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215552.

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Dzwiniel, Trevor L. "Seven-membered carbocycle synthesis by cobalt-mediated [3 + 2 + 2] allyl/alkyne cycloaddition reactions and novel [5 + 2] cyclopentadiene/alkyne ring expansions." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0033/NQ46833.pdf.

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Hsia, Kenneth Y. "Carbocycles from sugars." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260126.

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Joubert, Nicolas. "Synthèse et évaluation de nouveaux nucléosides ciblant l'hépatite C dans un système réplicon." Phd thesis, Université d'Orléans, 2006. http://tel.archives-ouvertes.fr/tel-00250329.

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Le virus de l'hépatite C est un problème de santé publique majeur, puisque 180 millions de personnes sont chroniquement infectées dans le monde, et sont susceptibles de présenter une cirrhose ou un cancer du foie. Un seul traitement a été approuvé, à base de Ribavirine et d'interféron alpha, mais il permet de traiter moins de 50 % des personnes infectées, et présente de nombreux effets secondaires. Devant ce constat, il parait urgent d'aboutir à une polythérapie plus adaptée. En dépit du succès des nucléosides en chimie antivirale, visant plusieurs enzymes clefs intervenant dans la réplication virale, peu d'entre eux ont été conçus pour viser l'ARN polymérase ARN dépendante nécessaire au VHC. Dans cette optique, de nouveaux dérivés carbocycliques de la Ribavirine, et des dérivés nucléosidiques du type 5-haloéthynyl- ou 5-(1,2-dihalo)vinyluracile, ont été synthétisés en utilisant deux méthodes : la réaction de Sonogashira et la cyclisation 1,3-dipolaire. Ce sont des outils puissants de la chimie organique qui permettent l'accès à de nouvelles structures nucléosidiques et la réalisation de modifications chimiques ultérieures. Les nouveaux composés ainsi préparés ont été testés pour leur activité antivirale.
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Joussot, Jessie. "Stratégies de synthèse d’un nouvel antipsychotique potentiel : cascades réactionnelles palladocatalysées : un outil puissant pour la synthèse de structures polycycliques complexes et hautement fonctionnalisées." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF016/document.

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Ces travaux de thèse ont permis dans un premier temps, d'aborder différentes voies de synthèse d'un nouvel antipsychotique potentiel (F17464) proposé par les laboratoires Pierre Fabre. Trois stratégies basées sur des synthèses convergentes ont été initiées. La première stratégie repose sur une étape clé de métathèse croisée, la seconde sur une réaction de Sonogashira et la troisième aborde une nouvelle méthodologie d'alkylation des chromones en position 3. Ces méthodes nous ont permis d'accéder à des intermédiaires de synthèse originaux, utiles pour préparer la molécule F17464 en respectant les contraintes industrielles.Dans un deuxième temps, différents types de molécules polycycliques complexes ont été synthétisés par cascades réactionnelles palladocatalysées. Une série de naphtalènes condensés a été préparée par réaction domino palladocatalysée issue de cyclocarbopalladations successives suivies d'une activation C(sp2)-H. Plusieurs types de cycles à sept atomes de carbone condensés ont été synthétisés en une seule étape, à partir de substrats faciles d'accès, via des cascades réactionnelles cyclocarbopalladations/activation C(sp2) ou C(sp3)-H.Finalement, des cyclooctatriènes et des fenestradiènes ont été obtenus à partir du même substrat,en une seule étape, via des réactions en cascade débutant par une cyclocarbopalladation 4-exodigsuivie d'un couplage de Stille puis d'une addition d'alcynes sur une triple liaison s'achevant par des réactions d'électrocyclisations. La température est le seul paramètre réactionnel qui diffère dans la synthèse de ces deux polycycles complexes, à partir du même substrat
This PhD thesis allowed us in the first part to develop different synthesic pathways to a new potential antipsychotic (F17464) invented by Pierre Fabre laboratories. Three strategies based on convergent syntheses are initiated. The key step of the first strategy is olefin cross metathesis. The second strategy rests on Sonogashira coupling and the third one involves a new methodology ofchromones alkylation in position 3. These methods allowed us access to novel synthetic intermediates, useful in the preparation of the F17464 molecule by following industrial confines.ln the second part, different types of polycyclic molecules were synthesized by palladium-catalyzed cascade reactions. A set of fused naphthalenes was prepared by palladium-catalyzed dominoreaction including cyclocarbopalladations followed by C(sp2)-H bond activation. Several types of fused seven-membered carbocycles were synthesized in a one-pot reaction from convenient substrates, via cascade reactions including cyclocarbopalladations followed by C(sp2 or sp3)-Hbond activation. Finally, cyclooctatrienes and fenestradienes were obtained also in a one-pot reaction from the same substrate via cascade reactions involving 4-exo-dig cyclocarbopalladation, followed by Stille coupling, alkyne addition onto a triple bond, finishing by electrocyclization reactions. Temperature is the only parameter that differs in the synthesis ôf the two complex polycycles starting from the same substrate
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Polomska, Marta Ewa. "Towards a total synthesis of mensacarcin." Doctoral thesis, [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=976248018.

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Books on the topic "Carbocycle"

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Carbocycle construction in terpene synthesis. New York, N.Y: VCH, 1988.

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Lloyd, Douglas, ed. Topics in Carbocyclic Chemistry. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4684-8270-6.

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Agrofoglio, L. A., and S. R. Challand. Acyclic, Carbocyclic and L-Nucleosides. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-007-0816-7.

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Li, Jie Jack, ed. Name Reactions for Carbocyclic Ring Formations. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470872215.

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Culshaw, Andrew James. Intramolecular cycloadditions of carbonyl oxides to alkenes: A new approach to oxygenated carbocycles. Salford: University of Salford, 1989.

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Stansfield, Kevin. Diels-alder reactions of fluoroalkenes: New strategy and tactics in the synthesis of fluorinated carbocycles. Birmingham: University of Birmingham, 1996.

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Hay, Philip A. The design and synthesis of novel carbocyclic transition-state analogues of glycoside hydrolysis. Manchester: UMIST, 1997.

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Ho, Tse-Lok. Carbocycle Compounds in Terpene Synthesis. Wiley-VCH, 1988.

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Topics in Carbocyclic Chemistry. Springer My Copy UK, 1995.

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Agrofoglio, L., and S. R. Challand. Carbocyclic, Acyclic and L-Nucleosides. Springer, 1998.

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Book chapters on the topic "Carbocycle"

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Nair, Vijay, and Rony Rajan Paul. "Five-Membered Carbocycles." In Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis, 157–84. Hoboken, NJ, USA: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119006220.ch6.

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Frost, Heather N., and David H. Brown Ripin. "Naming Carbocycles and Heterocycles." In Practical Synthetic Organic Chemistry, 703–70. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118093559.ch17.

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Thummel, R. P. "Carbocyclic Annelated Pyridines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 253–445. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186701.ch2.

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Figueiredo, Renata Marcia de, Gilles Niel, and Jean-Marc Campagne. "Three- and Four-Membered Carbocycles." In Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis, 115–56. Hoboken, NJ, USA: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119006220.ch5.

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Buono, Gérard, Hervé Clavier, Laurent Giordano, and Alphonse Tenaglia. "Seven- and Eight-Membered Carbocycles." In Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis, 211–40. Hoboken, NJ, USA: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119006220.ch8.

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Cheung, Kwan Yin, and Qian Miao. "Polycyclic Arenes Containing Seven-Membered Carbocycles." In Polycyclic Arenes and Heteroarenes, 85–110. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527689545.ch4.

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Deng, Chun-Lin, Xiao-Shui Peng, and Henry N. C. Wong. "Polycyclic Arenes Containing Eight-Membered Carbocycles." In Polycyclic Arenes and Heteroarenes, 111–42. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527689545.ch5.

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Amatore, Muriel, Corinne Aubert, Marion Barbazanges, Marine Desage-El Murr, and Cyril Ollivier. "Stereoselective Synthesis of Six-Membered Carbocycles." In Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis, 185–210. Hoboken, NJ, USA: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781119006220.ch7.

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Agrofoglio, L. A., and S. R. Challand. "The chemistry of carbocyclic nucleosides." In Acyclic, Carbocyclic and L-Nucleosides, 174–255. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-007-0816-7_4.

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Agrofoglio, L. A., and S. R. Challand. "Biological activity of carbocyclic nucleosides." In Acyclic, Carbocyclic and L-Nucleosides, 256–84. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-007-0816-7_5.

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Conference papers on the topic "Carbocycle"

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Šála, Michal, Hubert Hřebabecký, Milena Masojídková, and Antonín Holý. "Synthesis of novel racemic conformationally locked carbocyclic nucleosides." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507461.

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Mackman, R. L., C. G. Boojamra, J. Chen, J. Feng, Y. Gao, G. Laflamme, S. Lee, et al. "Synthesis and antiviral activity of 4'-modified carbocyclic nucleoside phosphonates (CNPs)." In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810191.

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Dejmek, Milan, Hubert Hřebabecký, Michal Šála, Martin Dračínský, and Radim Nencka. "Synthesis of conformationally locked carbocyclic nucleosides with norbornane as pseudosugar moiety." In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112208.

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Margetic, Davor, Ronald Warrener, Guangxing Sun, and Douglas Butler. "The Preparation of 7-Substituted Norbornadiene-2,3-dicarboxylic Anhydrides and a Theoretical and Experimental Study of their Thermolysis to 5-Membered Carbocyclic or Heterocyclic Anhydrides." In The 10th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2006. http://dx.doi.org/10.3390/ecsoc-10-01397.

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Reports on the topic "Carbocycle"

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Huang, Qinhua. New Palladium-Catalyzed Approaches to Heterocycles and Carbocycles. Office of Scientific and Technical Information (OSTI), December 2004. http://dx.doi.org/10.2172/835382.

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Secrist, John A., and III. Synthesis of Carbocyclic 3-Deazaadenosine Analogs as Potential Agents Against Poxvirus. Fort Belvoir, VA: Defense Technical Information Center, October 2000. http://dx.doi.org/10.21236/ada396210.

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