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Relevant bibliographies by topics / Carbocyclic / Dissertations / Theses

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Dissertations / Theses on the topic 'Carbocyclic'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 May 2024

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1

Phun, Lien Hoang. "Innovative approaches to carbocyclic and heterocyclic compounds using strained carbocycles." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47542.

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Natural products and small molecules play a major role in drug development. However, using natural products as a source of medicine comes with many challenges, such as lack of natural abundance and difficulty in isolation. Consequently, synthetic organic chemistry is a solution in order to access these compounds in usable quantities. However, synthetic chemisty comes with its own challenges such as efficiency, chemoselectivity, stereoselectivity and enantioselectivity. Therefore, synthetic tools that addresses these challenges are required solve these limitations. This thesis discusses new met

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2

Das, Jayanta. "Trans formative reactions on carbocyclic compounds." Thesis, University of North Bengal, 2015. http://ir.nbu.ac.in/handle/123456789/1863.

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3

Finniear, Aled. "Asymmetric synthesis of chiral carbocyclic nucleosides." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283609.

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4

Agathocleous, D. C. "Synthesis of carbocyclic analogues of penicillin." Thesis, University of Huddersfield, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304428.

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5

Palmer, Christopher Francis. "Synthesis of carbocyclic analogues of clitocine." Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277146.

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6

Hunt, Peter Alan. "Carbocyclic analogues of nikkomycins and polyoxins." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47482.

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7

Standen, Patricia E. "Metathesis routes to carbocyclic frame works." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/13204.

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The addition of allyl magnesium and allyl indium reagents to a key TBS protected norbornenyl building block, synthesised in 6-steps from commercially available 1,1-dimethoxy-2,3,4,5-tetrachlorocyclo-pentadiene, has been achieved providing the syn addition products with high diastereoselectivity. The subsequent exposure of the addition products to metathesis conditions, in the presence of ethylene, then provided cis fused [3.0.3]-carbocycles with very high regioselectivity, via a Ring Rearrangement Metathesis (RRM) transformation. The high level of regioselectivity is due to the rearrangement o

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8

Dossett, David Lawrence. "Alternatives to [4+1] carbocyclic annulations." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/101269.

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6-Carboethoxybicyclo [3.3.0] oct-6-en-2-one has been prepared by the intramolecular [4+1] cyclopentene annulation method. This compound and its precursor, 6-vinyl-6-carboethoxybicyclo[3.1.0]hexan-2-one were attained as the necessary standards for the investigation of the course of intramolecular Michael addition-alkylation sequence of l-phenylsulfonyl-6-carboethoxyocta-5,7-dien-2-one.<br>M.S.

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9

He, Mingzhu Schneller Stewart W. "Carbocyclic C-nucleosides derived from formycin." Auburn, Ala, 2008. http://hdl.handle.net/10415/1427.

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10

Ghosh, Pranab. "Studies on chemical reactions of carbocyclic compounds." Thesis, University of North Bengal, 1991. http://hdl.handle.net/123456789/767.

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11

Pradhan, Nagendra Narayan. "Studies on the chemical reactions of carbocyclic compounds." Thesis, University of North Bengal, 2002. http://hdl.handle.net/123456789/743.

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12

Mothay, jyotsna. "Studies on the transformative reactions of carbocyclic compounds." Thesis, University of North Bengal, 2002. http://hdl.handle.net/123456789/771.

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13

Mosley, Sylvester L. "Base-modified carbocyclic nucleosides as medicinal agents." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/27041.

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14

Bright, Steven. "Acid induced cationic rearrangements of carbocyclic compounds." Thesis, University of Canterbury. Chemistry, 1988. http://hdl.handle.net/10092/7597.

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This thesis examines fluorosulfonic acid as a reagent for use in organic synthesis. The acid strength of fluorosulfonic acid gives access to rearrangement products not available with weaker acids. The reaction of a selected series of benzyl carbinols with HSO₃F are reported. Reaction of 1-benzyl-2-methylcyclohexanol (1) gave cis-4a-methyl-1,2,3,4,4a,9a-hexahydrofluorene (2), while 1-benzyl -3-methylcyclohexanol (10) and 1-benzyl-4-methylcyclohexanol (11) were reduced to cis-1-benzyl-3-methylcyclohexane (12) and trans-1-benzyl-4-methylcyclohexane (13) respectively. [Diagram in thesis] 6-Ben

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15

Parry, David Mark. "Synthesis of some fluorinated carbocyclic nucleoside analogues." Thesis, University of Exeter, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305731.

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16

Shoberu, Karoline Adesola. "The biosynthesis and synthesis of carbocyclic nucleosides." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385737.

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17

Giustra, Zachary Xavier. "Studies of BN-Isosteres of Carbocyclic Systems." Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:108092.

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Thesis advisor: Shih-Yuan Liu<br>The first three chapters of this dissertation elaborate on certain facets of the isosteric relationship between different types of boron-nitrogen-containing heterocycles and the corresponding all-carbon compounds. In this vein, Chapter 1 describes selective photoisomerization of aromatic 1,2-dihydro-1,2-azaborines to BN-analogues of bicyclo[2.2.0]hexa-2,5-diene (Dewar benzene). In one instance, the photoisomer product was further derivatized into a series of disubstituted cyclobutanes through manipulations of the boron functionality. Chapter 2 discloses a combi

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18

Lau, Clifford James. "A study of several interesting carbocyclic molecules /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487584612166485.

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19

Van, Eeden Nestor. "Synthesis of some potential antimicrobial carbocyclic compounds." Thesis, Cape Technikon, 1994. http://hdl.handle.net/20.500.11838/745.

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Thesis (M. Diploma in Technology (Chemistry))--Cape Technikon, 1994<br>Some naturally occurring compounds containing the naphtho [2,3 - c] pyran ring system have been found to be useful antibiotic agents and thus the laboratory synthesis ofthese compounds and their derivatives are of importance in the medical field. Their antibiotic and even antineoplastic activities are attributed to their potential to act as alkylating agents, via a bioreductive process. This thesis deals with studies directed towards the synthesis of some benzo [c] pyrans as these compounds also possess the correct st

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20

Singha, Rabindranath. "Chemical transformation of carbocyclic compounds and development of novel reaction protocols." Thesis, University of North Bengal, 2021. http://ir.nbu.ac.in/handle/123456789/4326.

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21

Dutta, Gopal. "Chemical investigation of naturally occurring carbocyclic ring compounds." Thesis, University of North Bengal, 1989. http://hdl.handle.net/123456789/836.

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22

McGranaghan, Andrea. "Synthesis and evaluation of carbocyclic nicotinamide cofactor analogues." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30007.

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The history of the discovery and structure elucidation of many important nucleotides and coenzymes is reviewed in chapter 1. Some recent developments in nucleotide chemistry are also discussed including the discovery and biological importance of cyclic ADP ribose and carbocyclic nucleosides such as Aristeromycin and Neplanocin A. In chapter 2, the preparation of a carbocyclic analogue of NAD+ (figure 1) is reported. This analogue is synthesised both as a mixture of diastereoisomers which are separated by HPLC and as a single diastereoisomer via the homochiral synthesis. (Fig. 8742). In chapter

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23

Isakovic, Ljubomir. "Synthesis of the carbocyclic core of CP-225,917." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38208.

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A new method for the synthesis of the [4,3,1] carbocyclic core of the squalene synthase and farnesyl transferase inhibitor CP-225,917 is developed. The key step relies on the [6+4] cycloaddition between a tropone and a cyclopentadiene. This reaction proceeds with excellent regio- and stereoselectivity and allows rapid and convergent access to the polycyclic core of the molecule.<br>In the course of this work, it was discovered that the cycloaddition process is significantly accelerated in presence of the catalytic amount of ZnCl2. This is the first example of Lewis acid catalyzed [6+4] tropone

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24

Streete, Isla. "Towards the synthesis of carbocyclic sialic acid analogues." Thesis, Heriot-Watt University, 2003. http://hdl.handle.net/10399/421.

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25

Abbasali, Qasim Azad. "Early transition metal complexes of membered carbocyclic rings." Thesis, University of Sussex, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364135.

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26

Popescu, Anne. "Racemic carbocyclic nucleosides and their anti-viral activity." Lund : Lund University Chemical Center, 1995. http://books.google.com/books?id=5vhqAAAAMAAJ.

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27

Pellegrino, S. "Heterosubstituted carbocyclic Amino Acids : synthesis and stereocontrolled transformations." Doctoral thesis, Università degli Studi di Milano, 2005. http://hdl.handle.net/2434/58289.

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28

Chakraborty, Satyajit. "Studies on oxidative and reductive reactions of carbocyclic compounds." Thesis, University of North Bengal, 1988. http://hdl.handle.net/123456789/709.

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29

Jackson, Ian D. "A chemo-enzymatic approach to the synthesis of carbocyclic nucleosides and intermediates in the biosynthesis of carbocyclic nucleosides by Streptomyces citricolor." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/15092.

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The carbocyclic nucleosides aristeromycin I and neplanocin A II are produced from D-glucose by <i>Streptomyces citricolor</i>. (Fig. 8570A) To investigate the mechanism of the biosynthesis, an effective route to a putative intermediate III has been developed. By modifications to a known procedure, a single low yielding and unreliable reaction has been improved considerably. (Fig. 8570B) By using a <i>tert-</i>butyl-diphenyl silyl group in place of the acetyl group present in the original procedure, a more stable compound was obtained, which was tolerant to the insertion of a protected hydroxy

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30

Witherington, Jason. "Novel synthetic methods enabling the construction of biologically active compounds." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386942.

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31

Thorpe, Andrew John. "Synthetic approaches to novel adenosine analogues and the synthesis of potential antiviral agents." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357951.

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32

Chakraborty, Prasanta. "Chemical transformation of carbocyclic compounds and screening for their biological activity." Thesis, University of North Bengal, 2011. http://hdl.handle.net/123456789/1387.

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33

Cox, G. "Synthesis of carbocyclic analogues of the #beta#-lactam antibiotics." Thesis, University of Huddersfield, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374894.

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34

Bezoski, Brittany A. "Metal Binding Characteristics of Heterocyclic and Carbocyclic Anticancer Drugs." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1481287656969232.

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35

Singh, Rajinder. "Free radical ring expansion reactions." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293427.

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36

Hillman, Jennifer Mary Louise. "Antisense oligonucleotide analogues and cyclic adenosine monophosphate analogues as potential anti-viral and anti-cancer agents." Thesis, University of Exeter, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361317.

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37

Worakun, Tanachat. "Palladium and rhodium catalysed construction of carbocyclic and heterocyclic compounds." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317069.

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38

Grumann, Arne. "New routes to functionalised cyclopentenes as precursors to carbocyclic nucleosides." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297110.

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39

Paterson, Nicola Margaret. "Investigations into the biosynthesis of carbocyclic nucleosides by Streptomyces citricolor." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/11236.

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Aristeromycin 4 and neplanocin A 5 are biologically active carbocyclic nucleosides produced by the organism <i>Streptomyces citricolor</i>. Previous studies towards elucidating their biosynthesis have led to a proposed biosynthetic pathway in which D-glucose is converted <i>via</i> a number of carbocyclic intermediates to neplanocin A and aristeromycin. This thesis describes the studies that have been carried out in order to: i. identify the first formed carbocyclic intermediate on the biosynthetic pathway (Chapter 2). ii. determine the identity of the phosphorylated intermediates prior to nep

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40

Domínguez, Fernández Belén Ma. "New synthetic approaches towards carbocyclic analogues of natural nucleosides and nucleotides." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/30017.

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This thesis describes approaches towards the synthesis of some carbocyclic analogues of nucleosides and nucleaotides starting from the bicyclic lactam 1. The first compound considered was the analogue of cyclic adenosine diphosphate ribose 2. A crucial step in one of the retrosynthetic analyses involved conversion of a primary amine into a different functionality via a nucleophilic displacement of an amine derivative. Using a range of simple model compounds, attempts were made to achieve such a displacement via formation of a diazonium salt, a ditosyl imide or a pyridinium salt. Many side reac

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41

Coe, Diane Mary. "Synthesis of carbocyclic nucleoside and nucleotide analogues as potential antiviral agents." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294036.

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42

Muathin, H. A. "The synthesis of some carbocyclic and heterocyclic annilated derivatives of biphenylene." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332504.

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43

Niger, Robert J. "Application of organosilanes in [3 + 2] annulation approaches to carbocyclic compounds." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85342.

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44

Singha, Rabindranath. "Chemical transformation of carbocyclic compounds and development of novel reaction protocols." Thesis, University of North Bengal, 2021. http://ir.nbu.ac.in/handle/123456789/4348.

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45

White, Andrew Jonathan. "The development of novel photocycloaddition reactions for carbo- and heterocyclic synthesis." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323289.

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46

Varley, David Robert. "The synthesis of novel analogues of adenosine." Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307291.

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47

Tanaka, Kelly Sean Eichi. "Synthesis and evaluation of novel conformationally biased and carbocyclic based glycosidase inhibitors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/NQ51926.pdf.

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48

Duda, Blazej [Verfasser]. "Synthetic Approaches Towards Six-membered Hetero- and Carbocyclic Fluorinated Organophosphonates / Blazej Duda." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2013. http://d-nb.info/1035269554/34.

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49

Cotterill, Ian Charles. "Lipase catalyzed kinetic resolution and the asymmetric synthesis of carbocyclic oxetanocin A." Thesis, University of Exeter, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317336.

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50

Gooding, Heather. "The synthesis of carbocyclic and bicyclic nucleoside analogues as potential antiviral agents." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357140.

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