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Dissertations / Theses on the topic 'Carbohydrates dynamics'

Author: Grafiati
Published: 11 December 2022
Last updated: 19 February 2023

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1

Rönnols, Jerk. "Structure, dynamics and reactivity of carbohydrates : NMR spectroscopic studies." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-92408.

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The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the conformational equilibria and the rates of the associated interconversions are affected by the molecular constitution and their surroundings. The conformational equilibria of a group of amine linked pseudodisaccharides, designed as potential glycosidase inhibitors, comprising α-D-altrosides are described in Chapter 3. The OS2 conformation was largely populated, and the ring conformation was found to depend on the charge of the amine functionality. The conformations of β-D-xylopyranoside derivatives wi
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2

Östervall, Jennie. "Conformational Dynamics of Carbohydrates Studied by NMR Spectroscopy and Molecular Simulations." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1023.

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Carbohydrates play important roles in biological processes. Their function is closely related to their conformation. In this thesis, conformational studies of carbohydrates by NMR spectroscopy and molecular dynamics computer simulations are described. The first two papers discuss the anomalous solubility of β-cyclodextrin compared to other cyclodextrins. Time correlation functions revealed flexibility in all cyclodextrins. Molecular dynamics computer simulations showed that the glycosidic linkages were rather rigid and the flexibility was suggested to be macrocyclic. From spatial distribution
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3

Östervall, Jennie. "Conformational dynamics of carbohydrates studied by NMR spectroscopy and molecular simulations /." Stockholm : Department of Organic Chemistry, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1023.

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4

Eklund, Robert. "Computational Analysis of Carbohydrates : Dynamical Properties and Interactions." Doctoral thesis, Stockholm : Department of Organic Chemistry, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-538.

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5

Lay, Wesley K. "Optimizing computer simulation models for carbohydrates and proteins at the atomistic and coarse-grained level." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6603.

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Computer simulations allow researchers to study the dynamics and interactions of biological molecules in ways that cannot be currently achieved in experiments. In this work, I have used computer simulations to study the following systems: (1) carbohydrate-carbohydrate and carbohydrate-amino acid interactions using all-atom molecular dynamics simulations, and (2) protein-protein interactions using coarse-grained implicit solvent models. My first studies involved simulating carbohydrate and amino acid systems using atomistic force fields. During my initial simulations, I observed that carbohydra
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Eriksson, Mats [Verfasser]. "Molecular dynamics studies of the glycocalyx : carbohydrates in physiological water, and their interactions with FimH / Mats Eriksson." Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019869747/34.

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7

Rhoad, Jonathan S. "DNA-binding carbohydrates for coordination to a photoactive dirhodium complex and molecular dynamics studies of methyl furanosides: evaluation of available force fields." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1101315894.

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Rhoad, Jonathan Sidney. "DNA-binding carbohydrates for coordination to a photoactive dirhodium complex and molecular dynamics studies of methyl furanosides evaluation of available force fields /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1101315894.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xviii, 160 p.; also includes graphics Includes bibliographical references (p. 117-120). Available online via OhioLINK's ETD Center
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Kapla, Jon. "Computer Simulations of Membrane–Sugar Interactions." Doctoral thesis, Stockholms universitet, Institutionen för material- och miljökemi (MMK), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-127402.

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Carbohydrate molecules are essential parts of living cells. They are used as energy storage and signal substances, and they can be found incorporated in the cell membranes as attachments to glycoproteins and glycolipids, but also as free molecules. In this thesis the effect of carbohydrate molecules on phospholipid model membranes have been investigated by the means of Molecular Dynamics (MD) computer simulations. The most abundant glycolipid in nature is the non-bilayer forming monogalactosyldiacylglycerol (MGDG). It is known to be important for the membrane stacking typical for the thylakoid
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10

Alibay, Irfan. "Development and application of an enhanced sampling molecular dynamics method to the conformational exploration of biologically relevant molecules." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/development-and-application-of-an-enhanced-sampling-molecular-dynamics-method-to-the-conformational-exploration-of-biologically-relevant-molecules(774ad8b6-d531-47c7-8892-59d52e66e56e).html.

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This thesis describes the development a new swarm-enhanced sampling methodology and its application to the exploration of biologically relevant molecules. First, the development of a new multi-dimensional swarm-enhanced sampling molecular dynamics (msesMD) approach is detailed. Relative to the original swarm-enhanced sampling molecular dynamics (sesMD) methodology, the msesMD method demonstrates improved parameter transferability, resulting in more extensive sampling when scaling to larger systems such as alanine heptapeptide. The implementation and optimisation of the swarm-enhanced sampling
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11

Brodaczewska, Natalia Anna. "NMR and in silico studies of fucosylated chondroitin sulfate (fCS) and its interactions with selectins." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31232.

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This thesis describes structural studies on the interactions between the fucosylated chondroitin sulfate (fCS) oligosaccharides and human proteins known as selectins. fCS is a carbohydrate obtained from sea cucumbers, that can be classified as a branched glycosaminoglycan (GAG). It has attracted much attention due to its anti-coagulant, anti-inflammatory, antimetastatic and anti-HIV properties and its structure was previously determined by NMR. Selectins constitute a family of proteins involved in cell adhesion processes, such as inflammation, attachment of viral particles and migration of tum
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12

Lundborg, Magnus. "Computer-Assisted Carbohydrate Structural Studies and Drug Discovery." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-56411.

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Carbohydrates are abundant in nature and have functions ranging from energy storage to acting as structural components. Analysis of carbohydrate structures is important and can be used for, for instance, clinical diagnosis of diseases as well as in bacterial studies. The complexity of glycans makes it difficult to determine their structures. NMR spectroscopy is an advanced method that can be used to examine carbohydrates at the atomic level, but full assignments of the signals require much work. Reliable automation of this process would be of great help. Herein studies of Escherichia coli O-an
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13

Rojas-Cervellera, Víctor. "Ab initio molecular dynamics study of thiolate-protected gold clusters and their interaction with biomolecules." Doctoral thesis, Universitat Politècnica de Catalunya, 2015. http://hdl.handle.net/10803/317382.

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Thiolate monolayer-protected gold clusters (AuMPCs) are being used in various biological and biomedical applications due to their unique physical and chemical properties. The fact that gold-sulphur bonds are very stable enables the binding of biomolecules in the surface of gold clusters through a cysteine, an amino acid that contains a thiol group (SH). Specific AuMPCs-peptide conjugates can cross the blood-brain barrier without altering its integrity, opening the door for the treatment of pathologies related to the central nervous system, such as Alzheimer or Parkinson. Moreover, AuMPCs repre
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14

Zhang, Qiong. "Molecular Dynamics Simulations of Biomimetic Carbohydrate Materials." Doctoral thesis, KTH, Teoretisk kemi och biologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-33439.

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The present thesis honors contemporary molecular dynamics simulation methodologies which provide powerful means to predict data, interpret observations and widen our understanding of the dynamics, structures and interactions of carbohydrate systems. With this as starting point my thesis work embarked on several cutting edge problems summarized as follows. In my first work the thermal response in crystal cellulose Iβ was studied with special emphasis on the temperature dependence of the crystal unit cell parameters and the organization of the hydrogen bonding network. The favorable comparison w
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15

Kuttel, Michelle Mary. "Simulations of carbohydrate conformational dynamics and thermodynamics." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/6322.

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Includes bibliographical references.<br>In this thesis, free energy calculations are employed to establish the conformation freedom of selected carbohydrates. The focus is on the biologically important (1-4)-linked glucans, although the α(1-1) α and α(1-6) linkages are also investigated. Two principal types of potential of mean force (PMF) caltulation are used: free energy calculations for ratations about dihedral angles and end-to-end distance free energy calculations for the extension and compression of oligosaccharide strands.
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16

Best, Robert. "Combined NMR and simulation study of carbohydrate linkage dynamics." Master's thesis, University of Cape Town, 2000. http://hdl.handle.net/11427/6582.

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Includes bibliographical references.<br>Biomaterials have recently gained significance as a result of environmental pressures and their increased viability through crop engineering. Starch harvested from maize crops is one example of a cheap and abundant biopolymer, which could substitute conventional polymers such as polyethylene as a material in manufacturing. Its practical application, however, will depend on understanding its physical behaviour, so that intelligent modifications can be made to enhance its properties. The most effective way of changing a polymer's properties is by modificat
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Ramadugu, Sai Kumar. "Carbohydrate-protein interactions: structure, dynamics and free energy calculations." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1731.

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The current thesis presents work on the structure and dynamics of oligosaccharides and polysaccharides as well as the free energetics of carbohydrate-protein interactions. By applying various computational tools such as molecular dynamics simulation, our in-house fast sugar structure prediction software, replica exchange molecular dynamics, homology modeling, umbrella sampling, steered molecular dynamics as well as the thermodynamic integration formalism, we have been able to study the role of water on the surface of homopolysaccharides as well as complex oligosachharides, we have been able to
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18

Mulat, Teshome G. "Chemical desiccation tolerance and nonstructural carbohydrate dynamics in winter wheat." Access citation, abstract and download form; downloadable file 3.70 Mb, 2004. http://wwwlib.umi.com/dissertations/fullcit/3131690.

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19

Boulcott, Mat. "The dynamics of carbohydrate production, storage and excretion in epipelic diatoms." Thesis, University of Essex, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343503.

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20

Dong, Hai. "Efficient carbohydrate synthesis by controlled inversion strategies." Licentiate thesis, Stockholm : Chemical Science and Engineering, KTH, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4179.

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21

Mahon, Eugene. "Dynamic Constitutional Protein-Carbohydrate and Polyoxometalate Systems toward biomimetic sensors and membranes." Montpellier 2, 2009. http://www.theses.fr/2009MON20057.

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Le but de ce travail était d'explorer l'interaction entre les ensembles supramoléculaires constitutionnels et chimie dynamiques biomimétique et les motifs biologiques simples. La recherche a été effectuée dans les domaines d'intérêt suivants : l'interaction protéine-saccharides, les vésicules, les bicouches phospholipidiques, les canaux ioniques et le transport à travers une membrane et ont constituer trois axes de projet. Des nanoparticules ont été employée pour l'amplification de signal de fréquence d'une microbalance à cristal de quartz pour la recherche sur l'interaction de lectin-sacchari
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22

Wang, Diane Ran. "Genetic insights into stem non-structural carbohydrate dynamics in cultivated Asian rice, Oryza sativa." Thesis, Cornell University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10195720.

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<p>Rice plants (Oryza sativa) accumulate photo-assimilates in the form of non-structural carbohydrates (NSCs) in their stems prior to heading. These can later be mobilized to supplement photosynthate production during grain-filling. There has been longstanding enthusiasm by rice physiologists in optimizing stem NSC as a strategy for rice improvement. Despite this interest, documented since the 1970s and 80s, very little about the genetic controls regulating NSC accumulation, remobilization, and re- accumulation is known. In this dissertation, we first lay the groundwork for large-scale diversi
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23

Konidala, Praveen. "Molecular dynamics simulations of glycolipid and carbohydrate binding protein systems in the explicit water environment." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979967791.

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24

Karkle, Elisa Noemberg Lazzari. "Carbohydrate components of pomace in corn-based extrudates: interactions, expansion dynamics, and structure-texture relationships." Diss., Kansas State University, 2011. http://hdl.handle.net/2097/12059.

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Doctor of Philosophy<br>Department of Grain Science and Industry<br>Sajid Alavi<br>Extrusion processing is a technology widely used to make ready-to-eat snack and breakfast cereal products. The raw materials that result in optimal texture and consumer acceptance are mainly those with high levels of starch, which greatly limits the nutritional value of these products. One alternative to enhance the nutritional value is the incorporation of fruits and vegetables. Fruits and vegetables are consistently under-consumed by the American population and incorporation into extruded products may help
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25

Chung, Ying-Hua. "Water behavior in different biological environments." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1213.

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In this thesis, we report on our studies of water dynamics and structure in various biological environments which include: the surfaces of proteins and various oligosaccharides, the intervening space between proteins; and in the vicinity of cryoprotectant disaccharides in the liquid and ice phases. From a theoretical perspective, we propose methodology to compute diffusivity and residence times on the surface of biomolecules. In particular our proposed algorithm to compute residence times appears to be better in dealing with poor statistics associated with the number of water molecules that re
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26

Kognole, Abhishek A. "UNDERSTANDING CARBOHYDRATE RECOGNITION MECHANISMS IN NON-CATALYTIC PROTEINS THROUGH MOLECULAR SIMULATIONS." UKnowledge, 2018. https://uknowledge.uky.edu/cme_etds/80.

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Non-catalytic protein-carbohydrate interactions are an essential element of various biological events. This dissertation presents the work on understanding carbohydrate recognition mechanisms and their physical significance in two groups of non-catalytic proteins, also called lectins, which play key roles in major applications such as cellulosic biofuel production and drug delivery pathways. A computational approach using molecular modeling, molecular dynamic simulations and free energy calculations was used to study molecular-level protein-carbohydrate and protein-protein interactions. Variou
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27

Reeh, Philipp. "Dynamic Multivalency For The Recognition Of Protein Surfaces." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/283236.

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En esta tesis doctoral el concepto de multivalencia en el reconocimiento de proteínas (lectinas) con azúcares se combinó con la idea de la química dinámica combinatoria. Esto se aplicó, no sólo para sacar ventaja del efecto de la mejor afinidad de tales sistemas multivalentes, sino también para dotar al sistema con una mayor variedad de constituciones y geometrías. La determinación de las afinidades relativas de los miembros de la biblioteca dinámica dio una visión de los requisitos necesarios para la unión entre azúcares – lectina. El primer enfoque para acceder a los sistemas multivalent
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28

Timmer, Brian J. J. "Metals in Dynamic Chemistry: Selection & Catalysis." Doctoral thesis, KTH, Organisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-211492.

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In the adaptation to the oxidative environment on earth, metals played a crucial role for the evolution of life. The presence of metals also allowed access to advanced functions due to their unique coordination sphere and reactivity. This thesis focused on exploiting these unique properties for further development of the field of dynamic chemistry – a field in which adaptation plays a central role as well. The first part of the thesis aimed to create a better understanding of multivalent effects in carbohydrate-lectin interactions. By reversible ligand coordination to zinc ions one of the nano
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Larsson, Rikard. "Reversible Sulfur Reactions in Pre-Equilibrated and Catalytic Self-Screening Dynamic Combinatorial Chemistry Protocols." Licentiate thesis, Stockholm, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3917.

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30

Raich, Armendáriz Lluís Adrià. "Unveiling Protein-Substrate Interactions and Conformations that Influence Catalysis in Carbohydrate-Active Enzymes." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/586173.

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Enzymes have attracted the attention of chemists and biologists since long ago due to their molecular complexity and tremendous efficiency. They are highly specific catalysts that make chemical reactions possible at mild conditions with an astonishing rate enhancement. For this reason there have been many efforts to understand how these macromolecules work, trying to find out crucial factors that influence their activity. Whereas it is difficult to settle on how enzymes work in general, with hot debates over many years, significant progress has been made in elucidating specific catalytic mecha
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Alonso, Gil Santiago. "Conformational and mechanistic analyses of α- and β-glycosidase substrates by ab initio QM/MM methods". Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/462805.

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Carbohydrates are one of the most important biochemical molecules due to their role as energetic resource for non-photosynthetic organisms, cell-cell recognition and adhesion, protection of cell membranes of bacteria and plants and ensure the proper functionality of several enzymes. Glycoproteins are important components of cell surfaces and the extracellular medium where molecular-cell interactions take place. Defects in the activity of glycoproteins are the cause of several human diseases, such as diabetes and lysosomal storage diseases. Glycoside hydrolases (GHs) are one of the most releva
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32

Uhrová, Lucie. "Dynamika akumulace nestrukturních sacharidů a aktivity enzymu Rubisco při zvýšené koncentraci oxidu uhličitého a manipulaci sinku u buku lesního." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2012. http://www.nusl.cz/ntk/nusl-216886.

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This diploma thesis deals with dynamic of accumulation of non-structural carbohydrates and activity of Rubisco enzyme at elevated concentration of CO2 on beech (Fagus sylvatica L.). Three years old seedlings of beech were cultivated in minisphere with ambient (385 µmol•mol-1, variant A), and with elevated concentration CO2 (700 µmol•mol-1, variant E) for four months. In every variant the first half of plants was fertilized by nitrogen (variant N+) and the second half was control (variant N-). Plants used for experiment were at first adapted for darkness for 12 hours. Subsequently tested leaves
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Santos, Maruska d'Aparecida. "Eficácia da dieta fracionada e restritiva de carboidratos em pacientes portadores de distúrbios do equilíbrio corporal associados a alterações do metabolismo da glicose por meio da posturografia dinâmica computadorizada, disability." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-09012013-173414/.

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INTRODUÇÃO: O consumo mundial de açúcar triplicou nos últimos 50 anos e a sua ingesta abusiva é responsável pela resistência periférica à insulina, que origina a síndrome metabólica - obesidade, diabetes melito, hipertensão arterial e doenças coronarianas . Motivados pelo elevado número de pacientes que nos procuram com queixas vestibulares associadas aos distúrbios de metabolismo da glicose (DMG) resolvemos avaliar de forma objetiva, a influência dos DMG nas disfunções labirínticas e o efeito da dieta restritiva de carboidratos como forma de tratamento. OBJETIVO: Observar o impacto da dieta f
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Rabe, von Pappenheim Fabian. "Novel Insights in Structure and Mechanism of Escherichia coli Transketolase." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-002E-E3EE-6.

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35

Nzunda, Emmanuel F. "Resprouting and multi-stemming and the role of the persistence niche in the structure and dynamics of subtropical coastal dune forest in KwaZulu-Natal province, South Africa." Thesis, 2008. http://hdl.handle.net/10413/76.

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Resprouting is an important means of plant regeneration especially under conditions that do not favour regeneration through seeding such as frequent disturbances, low productivity, unfavourable soil conditions, extreme cold and limited understorey light availability. Sprouts may be advantageous over seedlings because they have higher survival and growth rates than seedlings, since they use resources from parent plants unlike seedlings that have to acquire their own resources. Resprouting is well documented for ecosystems that experience severe disturbances that damage aboveground biomass. For
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Viator, Ryan Patrick. "Investigation of cotton growth temperature and carbohydrate dynamics /." 2003. http://www.lib.ncsu.edu/theses/available/etd-06232003-114209/unrestricted/etd.pdf.

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(9790343), Kishor Dahal. "Insights into seasonal yield variation in subtropical table grape production." Thesis, 2019. https://figshare.com/articles/thesis/Insights_into_seasonal_yield_variation_in_subtropical_table_grape_production/13468785.

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Table grape (cv. Menindee Seedless) production from a vineyard in Emerald, Central Queensland, demonstrated a strong alternate bearing pattern in seven consecutive seasons (P < 0.02) and irregular bearing in another seven seasons. Variation in vine yield was 78–90% attributable to the variation in bunch number. A sampling methodology for estimation of vine yield was recommended, and a machine vision-based system for rapid estimation of berry number and size was introduced. Low yields were attributed to low bud fertility, with only one inflorescence primordium (IP) in fruitful buds, and to poor
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Hadaidi, Ghaida A. "Coral-Associated Bacterial Community Dynamics in Healthy, Bleached, and Disease States." Diss., 2018. http://hdl.handle.net/10754/630144.

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Coral reefs are the proverbial rainforests of the ocean, but these spectacular structures are under threat from globally rising sea surface temperatures and ocean acidification. The Red Sea and the Persian/Arabian Gulf (PAG) display unusually high sea surface temperatures, and therefore, provide a model for studying environmental change. Corals are so-called holobionts consisting of the coral host, photosynthetic algae (Symbiodiniaceae), along with other microorganisms, such as bacteria, archaea, fungi, and viruses. While the importance of bacteria to coral holobiont functioning is ackno
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Konidala, Praveen [Verfasser]. "Molecular dynamics simulations of glycolipid and carbohydrate binding protein systems in the explicit water environment / von Praveen Konidala." 2006. http://d-nb.info/979967791/34.

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Zhang, Li-Xiang, and 張立詳. "Annual Variations of Carbohydrate Content Dynamics in Taiwanese Urban Trees —A Case Study of Camphor and Sweetgum Trees." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/65793814578604663773.

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碩士<br>國立中興大學<br>園藝學系所<br>105<br>Carbohydrate is an index that has been developed for near a hundred years in plant physiology. As an autotroph, plants depend on photosynthate, or glucose, as their only source of energy. Carbohydrate also serves as materials of respiration, wood building, and defensive chemicals production. Owing to aforementioned reasons, carbohydrate content dynamics in different parts of plants show how plants distribute photosynthate and how they survive under various environments. Also, the best preserving way of trees in human cognition is to understand physiology of tree
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Chih, Fang-Mei, and 池芳美. "Study on the ruminal degradation dynamic of protein and carbohydrate fractions of ingredient through in situ and in vitro methods." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/76787668914173562189.

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碩士<br>國立中興大學<br>畜產學系<br>89<br>Before the NRC net energy and metabolizable protein system can be effectively applied to local dairy farming in Taiwan, digestive kinetic information regarding the protein and carbohydrate fractions of the major feedstuff used in dairy diets should be established. Three fistulated cows were used in an in situ nylon bag study with nine consecutive ruminal incubation times for each duplicate sample to derive the degradation rate and availability (or degradability) of feedstuff calculated through a nonlinear regression model system. The degradability of feedstuff at
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Profant, Václav. "Struktura a dynamika peptidů a proteinů v roztoku:aplikace Ramanovy optické aktivity." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-369545.

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The thesis inquires the specific and advantageous applications of Raman optical activity (ROA) in wide range of diverse structural and conformational studies of biomolecules and other biologically important molecules. Our investigation was focused on several interconnected topics covering the fields of methodology, basic and applied research. The combination of experimental and theoretical approaches facilitated deeper understanding of studied phenomena, and allowed for the effects of solute-solvent interactions. High-quality spectra of model molecules in the C-H stretching region, acquired as
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"Development, growth and ultrastructure of the floral nectar spur of Centranthus ruber (L.) DC (Valerianaceae)." Thesis, 2013. http://hdl.handle.net/10388/ETD-2013-07-1117.

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The main objective of this research project was to study the growth and development of the floral nectar spur of Centranthus ruber (L.) DC. Nectar spurs are tubular floral outgrowths, generally derived from the perianth organs, which typically contain secreted floral nectar. The morphological characteristics of the spur, particularly the length, determine which floral visitors will be able to access the nectar reward pooled at the spur tip. Therefore, nectar spurs are ecologically important for the development of specialised pollinator interactions and have been demonstrated to act as key inno
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Barker, Megan. "Structural Investigation of Processing α-Glucosidase I from Saccharomyces cerevisiae". Thesis, 2010. http://hdl.handle.net/1807/32660.

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N-glycosylation is the most common eukaryotic post-translational modification, impacting on protein stability, folding, and protein-protein interactions. More broadly, N-glycans play biological roles in reaction kinetics modulation, intracellular protein trafficking, and cell-cell communications. The machinery responsible for the initial stages of N-glycan assembly and processing is found on the membrane of the endoplasmic reticulum. Following N-glycan transfer to a nascent glycoprotein, the enzyme Processing α-Glucosidase I (GluI) catalyzes the selective removal of the terminal glucose re
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