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Journal articles on the topic 'Carbon Tetrachloride (CCL4)'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Boll, Meinrad, W. D. Lutz, Eberhard Becker, and Andreas Stampfl. "Mechanism of Carbon Tetrachloride-Induced Hepatotoxicity. Hepatocellular Damage by Reactive Carbon Tetrachloride Metabolites." Zeitschrift für Naturforschung C 56, no. 7-8 (2001): 649–59. http://dx.doi.org/10.1515/znc-2001-7-826.

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CCl4-induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent binding of CCl4 metabolites to cell components and/or peroxidative damage as the cause of injury.(1) Covalent binding of 14C-labeled metabolites was detected in hepatocytes immediately after exposure to CCl4. (2) Low oxygen partial pressure increased the reductive metabolism of CCl4 and thus covalent binding. (3) [14C]-CCl4 was bound to lipids and to proteins throughout subcellular fractions. Binding occurred preferentially to triacylglycerols and phospholipids, with p

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Yamashiro, S., T. Bast, R. A. Towner, E. G. Janzen, and L. A. Reinke. "Role of Kupffer cells in CCl4-induced hepatocytic toxicity: A preliminary study." Proceedings, annual meeting, Electron Microscopy Society of America 51 (August 1, 1993): 392–93. http://dx.doi.org/10.1017/s042482010014779x.

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Carbon tetrachloride (CCl4) hepatotoxicity is one of the most frequently used experimental models to study the mechanism of cell damage by metabolites of xenobiotics (1,2). Cytochrome P-450 enzymes are considered to be involved in the metabolic activation of CCl4 to generate the trichloromethyl (.CCl3), which in turn may be converted to the peroxy radical (.00-CCl3) (3,4). In our previous studies, we have demonstrated CCl4-induced edematous response by using proton magnetic resonance imaging and electron microscopy (2,5). However, these studies have not given any consideration to Kupffer cells

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Dwirini Retno Gunarti, Reni Paramita, Syailendra Karuna Sugito, and Istiqomah Agusta. "Rice brain administration reduces malondialdehyde (MDA) levels in the heart of carbon tetrachloride-induced rats." World Journal of Biology Pharmacy and Health Sciences 18, no. 2 (2024): 403–9. http://dx.doi.org/10.30574/wjbphs.2024.18.2.0307.

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Excessive production of free radicals proven associated with disease progression of coronary heart disease. Rice bran oil has a high content of antioxidants such as tocopherol, tocotrienol, and γ-oryzanol. This study aimed to determine the effect of rice bran oil administration on malondialdehyde (MDA) level as an oxidative stress biomarker in the heart of carbon tetrachloride (CCl4)-induced rats. Thirty stored rat heart tissue samples that were divided into six groups, consisted of untreated control group, CCl4-treated group (CCl), rice bran oil-treated before CCl4 induction groups with rice

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Adebukola, Adeyanju Anne. "Protective Effect of Protocatechuic Acid in Genotoxicity-Induced by Carbon Tetrachloride: A Preliminary Study." Advances in Clinical Toxicology 8, no. 3 (2023): 1–5. http://dx.doi.org/10.23880/act-16000273.

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Carbon tetrachloride (CCl4) is commonly utilized as a solvent, a refrigerant, and a dry-cleaning agent. However, its genotoxic effect has been well documented. The present work was designed to assess the genotoxic effect of carbon tetrachloride in the bone marrow of rats. The safety and the possible protective effect of protocatechuic acid (PCA) in the genotoxicity induced by carbon tetrachloride (CCl4) were evaluated using a micronucleus assay. Rats were divided into six groups where groups I and II served as the control. Group III was exposed to CCl4 only at 3mL/kg intraperitoneally. Groups

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Firdous, Sayeed Mohammad, and Marwa A. A. Fayed. "Effects of Medicinal Plants on Carbon Tetrachloride-Induced Liver Injury: A Review." INNOSC Theranostics and Pharmacological Sciences 4, no. 2 (2023): 23–32. http://dx.doi.org/10.36922/itps.v4i2.215.

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The liver is the primary organ for metabolizing and eliminating foreign chemicals. When liver cells are exposed to large concentrations of dangerous substances, hepatocyte malfunction, membrane damage, and degradation may occur. Another chemical that can harm the liver is carbon tetrachloride (CCl4). CCl4 is converted into trichloromethyl radical [CCl3]- by several cytochrome P450 isoforms. [CCl3]- subsequently reacts with oxygen to generate trichloromethyl peroxyl radical [CCl3OO]- and induce lipid peroxidation in cell membranes. In this study, the mechanism by which a variety of recently ide

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Hsieh, Chien Te, Jin Ming Chen, Yue Hao Huang, Rong Rong Kuo, Chung Tien Li, and Han Chang Shih. "Adsorptive Surface Coverage of Carbon Tetrachloride onto Carbon Nanofibers Array." Solid State Phenomena 121-123 (March 2007): 417–24. http://dx.doi.org/10.4028/www.scientific.net/ssp.121-123.417.

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This work explores an estimation of adsorptive surface coverage for carbon tetrachloride onto different carbon nanofibers (CNFs). Two kinds of CNFs with various pore characteristics are fabricated by template-based and thermal chemical vapor deposition methods, respectively. The pore size distributions of these carbons, determined according to the density functional theory model, are found to vary with synthesis methods. The results of adsorption experiments show that CCl4 adsorption isotherms of these CNFs are of Langmuir-type model during the restricted pressure of 0–0.2 atm at 30°C. The sur

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Mughal, Tafail Akbar, Shaukat Ali, Shazia Khatoon, Saeed Khalil, and Shumaila Mumtaz. "Protective effect of Helianthus annuus seeds extract against CCl4-induced hepatocellular damage." Pakistan Journal of Biochemistry and Biotechnology 4, no. 2 (2023): 37–45. http://dx.doi.org/10.52700/pjbb.v4i2.97.

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Carbon tetrachloride (CCl4) is a hepatotoxin that causes toxicity in animals on its exposure. Hepatotoxins lead to hepatic demage that is treated by generating antioxidant effect. Synthetic and as well as natural drugs are available for this purpose but phyto-based herbal medicines got paramount importance against drug induced hepatotoxicity Current research was conducted to inspect the protective effect of aqueous extract of Helianthus annuus seeds pre-treatment on the carbon tetrachloride-induced hepatotoxicity in Balb C mice. Study covered the valuation of the enzymatic activity such as ala

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8

Fraser, Paul J., Bronwyn L. Dunse, Alistair J. Manning, et al. "Australian carbon tetrachloride emissions in a global context." Environmental Chemistry 11, no. 1 (2014): 77. http://dx.doi.org/10.1071/en13171.

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Environmental context Carbon tetrachloride in the background atmosphere is a significant environmental concern, responsible for ~10% of observed stratospheric ozone depletion. Atmospheric concentrations of CCl4 are higher than expected from currently identified emission sources: largely residual emissions from production, transport and use. Additional sources are required to balance the expected atmospheric destruction of CCl4 and may contribute to a slower-than-expected recovery of the Antarctic ozone ‘hole’. Abstract Global (1978–2012) and Australian (1996–2011) carbon tetrachloride emission

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Naz, Sana, Faisal Irshad, and Hina Mawani. "CCl4 INDUCED LIVER INJURY;." Professional Medical Journal 24, no. 05 (2018): 739–44. http://dx.doi.org/10.29309/tpmj/2017.24.05.1298.

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Objectives: Evaluate the mitigating effect of aqueous extract of Ginkgobiloba (GkbE) on liver enzymes and histology in carbon tetrachloride (CCl4) induced liverinjury in albino rat. Study design: Experimental study. Setting and Duration: Animal house,Bhitai Dental and Medical College Mirpurkhas and Agriculture University Tando Jam fromAnimal house from May 2015 - August 2016. Subjects and Methods: Sixty rats were equallydivided into 3 groups Group 1- Controls (0.9% isotonic saline), Group 2- (CCl4 CCl4 1.0mg/kg intraperitoneal) and Group 3- (CCl4+ GkbE). Blood samples were collected at end ofe

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Liu, Hsu-Jan, Sheng-Feng Hsu, Chang-Chi Hsieh, et al. "The Effectiveness of Tsu-San-Li (St-36) and Tai-Chung (Li-3) Acupoints for Treatment of Acute Liver Damage in Rats." American Journal of Chinese Medicine 29, no. 02 (2001): 221–26. http://dx.doi.org/10.1142/s0192415x01000253.

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This study investigated the effects of acupuncture on carbon tetrachloride (CCl4) induced acute liver injury in male rats (n = 36). The experimental groups were injected with CCl4 before, during, or after acupuncture therapy. Acupoints similar to the human Tsu-San-Li (St-36) and Tai-Chung (Li-3) were needled bilaterally. Rats treated with CCl4 had higher levels of serum glutamate-oxalate-transaminase (sGOT) and serum glutamate-pyruvate-transaminase (sGPT). Comparing the experimental groups, biochemical and pathological parameters of liver injury were significantly reduced when rats were acupun

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Mukhammadieva, Guzel F., T. G. Kutlina, D. O. Karimov, Ya V. Valova, E. F. Repina, and N. Yu Khusnutdinova. "ANALYSIS OF CHANGES IN CASP7 AND CHEK1 GENES EXPRESSION IN LIVER TOXIC DAMAGE INDUCED BY TETRACHLORMETHANE AGAINST THE BACKGROUND OF HEPATOPROTECTORS." Hygiene and sanitation 98, no. 9 (2019): 1011–14. http://dx.doi.org/10.18821/0016-9900-2019-98-9-1011-1014.

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Introduction. The effect of hepatoprotectors on the expression of genes involved in the regulation of apoptosis and the cell cycle (Casp7 and Chek1) under the toxic effects of carbon tetrachloride (carbon tetrachloride, CCl4) was studied. Material and methods. Studies were performed in male albino mongrel rats (n=70), assigned to the control group, modulated with CC14-induced toxic hepatitis and three experimental ones in which the administration of drugs (Heptor, Mexidol and Methyluracil) was carried out 1 hour before CCl4 administration. After 24 and 72 h of CCl4 administration animals were

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Krisnansari, Diah, Hidayat Sulistyo, and Wahyu Dwi Kusdaryantoi. "Hepatoprotective Potential of Propolis toward Hepar Injury Rats (Rattus norvegicus) Induced by Carbon Tetrachloride." Jurnal NERS 9, no. 2 (2016): 270. http://dx.doi.org/10.20473/jn.v9i22014.270-278.

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Introduction: The prevalence of chronic liver disease continues to increase. One potentially hepatotoxic substances that cause chronic liver disease is carbon tetrachloride. The process of liver damage can be prevented by the antioxidant role of propolis. The aims of this research was to study the hepatoprotective potential of propolis toward hepar injury rats induced by carbon tetrachlorida. Method: This was an experimental study with pre-post test. Twenty five male Wistar rats aged 12–16 week old, weighing 125–200 gr were allocated into 5 groups. Group I: standard meal + aquadest-gavage; gro

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Zhu, Xueqiang, Yuncong Li, Baoping Han, Qiyan Feng, and Lai Zhou. "Degradation Characteristics of Carbon Tetrachloride by Granular Sponge Zero Valent Iron." International Journal of Environmental Research and Public Health 18, no. 23 (2021): 12578. http://dx.doi.org/10.3390/ijerph182312578.

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Granular sponge zero valent iron (ZVI) was employed to degrade carbon tetrachloride (CCl4). The effects of acidic washing, initial solution pH, and ZVI dosage on CCl4 degradation were investigated. Results showed that CCl4 was effectively removed by ZVI and approximately 75% of CCl4 was transformed into chloroform through hydrogenolysis. The rate of chloroform transformation was slower compared to that of CCl4, resulting in chloroform accumulation. CCl4 degradation was a pseudo first-order process. The observed pseudo first-order reaction rate constant (kobs) for CCl4 and chloroform were 0.113

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Ubhenin, A. E., I. Igbe, F. A. Adamude, and A. Falodun. "Hepatoprotective effects of ethanol extract of Caesalpiniabonduc against carbon tetrachloride induced hepatotoxicity in Albino Rats." Journal of Applied Sciences and Environmental Management 20, no. 2 (2016): 396–401. http://dx.doi.org/10.4314/jasem.v20i2.22.

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The present study was carried out to evaluate the Acute toxicity, hepatoprotective and in-vivo antioxidant activities of ethanolic extract of Caesalpinia bonduc leaf on carbon tetrachloride (CCl4) induced liver damage using Swiss albino rats . The ethanolic extract of the plant of C. bonduc were suspended in 5 % tragacanth and then administered orally at doses of 250 and 500 mg/kg body weight for fourteen days before intraperitoneally injection of Carbon tetrachloride (CCl4) at dose of 2 mL/kg body weight. The plant extracts at 250 and 500mg/kg b.wt showed a remarkable hepatoprotective and inv

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Omale, PE, KE Osioyibo, SO Okeniyi, MM Adeyemi, and S. Garba. "Chemical and Thermal Modification of Okaba Coal for Increased Surface and Adsorption Properties." Chemistry Research Journal 2, no. 3 (2017): 29–35. https://doi.org/10.5281/zenodo.13954887.

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Activated carbon produced from Okaba coal was modified using potassium hydroxide and phosphoric acid. The effect of this chemical modification was studied using carbon tetrachloride adsorption. Characterization of the activated carbons using scanning electron microscopy and FTIR analysis showed a greater development of porosity obtained by the modified activated carbons and the FTIR spectra displayed bands confirming the presence of hydroxyl, carboxyl and carbonyl functional groups. The predicted influence of chemical modification on activated carbon surface for carbon tetrachloride uptake and

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Tokofai, Bemela Mawulom, Kokou Idoh, Oyegunle Emmanuel Oke, and Amegnona Agbonon. "Hepatoprotective Effects of Vernonia amygdalina (Astereaceae) Extract on CCl4-Induced Liver Injury in Broiler Chickens." Animals 11, no. 12 (2021): 3371. http://dx.doi.org/10.3390/ani11123371.

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The aim of this study was to evaluate the effect of Vernonia amygdalina leaf extract (VALE) on the carbon tetrachloride-induced hepatotoxicity (CCl4) in broiler chickens. A total of 360-day-old broilers were divided into 4 treatments of 90 birds each consisting of 6 replicates of 15 birds each. The treatments were birds offered 1 mL/kg BW saline (control group), 100 mg/kg BW VALE, 1 mL/kg BW CCl4 (CCl4-treated group), and 100 mg/kg BW VALE + 1 mL/kg BW CCl4 (VALE + CCl4 group). Blood samples were collected at 42 days of age and analyzed for the liver enzymes: alanine aminotransferase (ALT), as

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17

Chipperfield, Martyn P., Qing Liang, Matthew Rigby, et al. "Model sensitivity studies of the decrease in atmospheric carbon tetrachloride." Atmospheric Chemistry and Physics 16, no. 24 (2016): 15741–54. http://dx.doi.org/10.5194/acp-16-15741-2016.

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Abstract. Carbon tetrachloride (CCl4) is an ozone-depleting substance, which is controlled by the Montreal Protocol and for which the atmospheric abundance is decreasing. However, the current observed rate of this decrease is known to be slower than expected based on reported CCl4 emissions and its estimated overall atmospheric lifetime. Here we use a three-dimensional (3-D) chemical transport model to investigate the impact on its predicted decay of uncertainties in the rates at which CCl4 is removed from the atmosphere by photolysis, by ocean uptake and by degradation in soils. The largest s

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Ananda, Tsend-Ayush Damba, Xiulan Su, and Khurelbaatar Nyamdavaa. "Hepatoprotective Effect of Silymarin Peptide on Carbon Tetrachloride-Induced Acute Liver Injury in Mice." Central Asian Journal of Medical Sciences 10, no. 3 (2024): 123–29. https://doi.org/10.24079/cajms.2024.03.005.

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Objective: Liver diseases and injuries are significant global health concerns; in particular, acute liver injury (ALI) is a prominent cause of liver diseases and is associated with high morbidity and mortality. The application of natural products in preventing and treating liver diseases is considerable. Silymarin and silymarin peptides derive from the Milk thistle (Silybum marianum). Still, they differ in their composition and effects: Silymarin is a complex mixture of flavonoids, primarily made up of silybinin, silybinin, and silychristin. Silymarin is well-known for its antioxidant, anti-

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Laylani, Layla A. S. "The Protective Effect of Panax Ginseng Root Extract against the Toxicity of Carbon Tetrachloride that Induces Infertility to Male Rabbits." Al-Mustansiriyah Journal of Science 28, no. 1 (2017): 55. http://dx.doi.org/10.23851/mjs.v28i1.312.

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The present study used 20 male rabbits that divided randomly to four groups (each group consist 5 rabbits), control group received only normal diet, the group received carbon tetrachloride (CCL4) for forty days, the group treated (orally) with carbon tetrachloride and (100mg/per day) root extract for forty days, the fourth treated with carbon tetrachloride and (200mg/per day) root extract for forty days. the rabbits that treated with carbon tetrachloride showed decreased in the counts, motility, number of living sperms and increased the deformity of sperms with decreased the levels of LH, FSH

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Wallin, Stefan, and Erik Walum. "Effects of Carbon Tetrachloride on Perfused Cultures of Hepatic and Neuronal Cells." Alternatives to Laboratory Animals 20, no. 2 (1992): 235–39. http://dx.doi.org/10.1177/026119299202000210.

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Cultured hepatocytes and hemisphere neurons from chick embryos and mouse neuroblastoma cells were exposed to carbon tetrachloride (CC14; 0, 1, 2, 3 and 4mM) for 1 hour, using a perfusion system developed for studying the effects of volatile substances. In the perfused cultures, three parameters were compared: lipid peroxidation, membrane integrity and cellular respiration. In addition, cytochrome C oxidase activity was determined after incubation of cell homogenates with CC14. A concentration-dependent increase in lipid peroxidation and membrane permeability was found in the neuroblastoma cell

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Ujowundu, Favour N., Nathan N. Oparaeche, Chinyere Henrientta Onuoha, Moshood Abiola Haruna, Chukwudoruo Sunday Chieme, and Cosmas O. Ujowundu. "Combretum dolichopentalum extract normalized biochemical and haematological parameters in carbon tetrachloride (CCL4) intoxicated rats." AROC in Natural Products Research 1, no. 2 (2021): 17–28. http://dx.doi.org/10.53858/arocnpr01021728.

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Background: The ethanol extract of Combretum dolichopentalum (EECD) is employed in Nigeria to stabilize the uterus after parturition. The ability of EECD to confer protection on rats destabilized by moderate concentrations of carbon tetrachloride (CCl4) was evaluated. Methods: Fifty rats were assigned to 5 groups of 10 rats each. The experimental animals after acclimatization were handled accordingly: Groups 1 and 2 respectively were maintained on food and water only throughout the study. Group 3, 4, and group 5 were pre-treated with 250 mg/kg and 500 mg/kg body weight of EECD and 50 mg/kg of

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Zhu, Xueqiang, Lai Zhou, Yuncong Li, Baoping Han, and Qiyan Feng. "Rapid Degradation of Carbon Tetrachloride by Microscale Ag/Fe Bimetallic Particles." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 2124. http://dx.doi.org/10.3390/ijerph18042124.

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Cost-effective zero valent iron (ZVI)-based bimetallic particles are a novel and promising technology for contaminant removal. The objective of this study was to evaluate the effectiveness of CCl4 removal from aqueous solution using microscale Ag/Fe bimetallic particles which were prepared by depositing Ag on millimeter-scale sponge ZVI particles. Kinetics of CCl4 degradation, the effect of Ag loading, the Ag/Fe dosage, initial solution pH, and humic acid on degradation efficiency were investigated. Ag deposited on ZVI promoted the CCl4 degradation efficiency and rate. The CCl4 degradation res

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Tang, Rong-Xing, Xiao-Jun Xie, Yong Xiong, Su Li, Chen Luo, and Yi-Gang Wang. "C23 ameliorates carbon tetrachloride-induced liver fibrosis in mice." World Journal of Hepatology 16, no. 9 (2024): 1278–88. http://dx.doi.org/10.4254/wjh.v16.i9.1278.

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BACKGROUND C23, an oligo-peptide derived from cold-inducible RNA-binding protein (CIRP), has been reported to inhibit tissue inflammation, apoptosis and fibrosis by binding to the CIRP receptor; however, there are few reports on its role in liver fibrosis and the underlying mechanism is unknown. AIM To explore whether C23 plays a significant role in carbon tetrachloride (CCl4)-induced liver fibrosis. METHODS CCl4 was injected for 6 weeks to induce liver fibrosis and C23 was used beginning in the second week. Masson and Sirius red staining were used to examine changes in fiber levels. Inflammat

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Marques, Thamirys Guimarães, Eleazar Chaib, Juliana Hamati da Fonseca, et al. "Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection." Acta Cirurgica Brasileira 27, no. 8 (2012): 589–94. http://dx.doi.org/10.1590/s0102-86502012000800013.

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PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after in

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Jain, Himanshu, and Yogesh Kumar Sharma. "A Review on Study of Hepatoprotective Activity of Chenopodium Album Linnon CCl4 Induced Hepatotoxicity in Rats." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 790–92. http://dx.doi.org/10.22270/jddt.v9i4-a.3614.

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The hepatoprotective activity of Chenopodium album Linn leaves against carbon tetrachloride (CCl4)-induced hepatotoxicity was investigated. Possibilities of Rat hepatocyte monolayer culture and rats were used as in vitro and in vivo hepatoprotective screening models also very useful. In the in vitro studies, different extracts and fraction we can screened. Silymarin can be used as reference drug. In the in vivo studies, hepatotoxicity was induced in wistar rats species give satisfactory results as per reported methods and administering a mixture of CCl4: olive oil (1:1, 2 ml/kg, s.c.) can be u

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Ahmet Ozkaya, Ahmet Ozkaya, Zafer Sahin Zafer Sahin, Seyda Cagri Bulbul Seyda Cagri Bulbul, Mirac Uckun Mirac Uckun, and Ertan Yologlu Ahmet Turk and Yusuf Ozay Ertan Yologlu Ahmet Turk and Yusuf Ozay. "The Projective Effect of Pomegranate Juice on Fibrosis, Carboxylesterase Activity and Fatty Acid Profile in Rat Liver Tissues Exposed to Carbon Tetrachloride." Journal of the chemical society of pakistan 47, no. 2 (2025): 155. https://doi.org/10.52568/001640/jcsp/47.02.2025.

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: In this study, it was aimed to investigate the effects of pomegranate juice (PJ) on liver carboxylesterases (Ces), oxidative stress parameters, liver histology, and fatty acids in rats exposed to carbon tetrachloride (CCl4). Adult male Wistar albino rats were randomly divided into four groups as control, CCl4, PJ, and CCl4+PJ (n=7 in each group). We determined that the decrease in Ces activity due to CCl4-induced liver damage was alleviated by PJ. Moreover, PJ reduced CCl4-induced oxidative stress, liver degeneration, and apoptosis. While the CCl4 group increased the 15:0, 16:0 fatty acid le

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TRISTININGRUM, WIWIK YULIA, MARTI HARINI, and TETRI WIDIYANI. "Effect of garlic extract (Allium sativum) on hepatic microanatomy structure and serum glutamate-pyruvate transaminase levels in rats after oral treatment of CCl4." Biofarmasi Journal of Natural Product Biochemistry 4, no. 2 (2006): 72–78. http://dx.doi.org/10.13057/biofar/f040205.

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Garlic (Allium sativum L.) is known to have various pharmacological activities, such as antidiabetic, antihypertensive, anti-cholesterol, anti-atherosclerosis, thrombocyte antiaggregation, initiate fibrinolysis, antiviral and antimicrobial, anticancer and antioxidant. The objectives of this research were to determine the effect of garlic extract (Allium sativum L.) on the microanatomy structure of liver and the serum glutamate-pyruvate transaminase (SGPT) levels in rats (Rattus norvegicus L.) after the oral treatment of carbon tetrachloride (CCl4). The study was conducted by using 25 Wistar st

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Watiniasih, Ni, Dewa Swastini, Luh Harini, et al. "In vivo investigation of Roselle flower (Hibiscus sabdariffa L.) and Bee pollen (Tetragonula laeviceps) on carbon tetrachloride-induced spermatozoa damage." Tropical Journal of Pharmaceutical Research 24, no. 1 (2025): 77–83. https://doi.org/10.4314/tjpr.v24i1.11.

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Purpose: To determine the effect of roselle flower and bee pollen on carbon tetrachloride (CCl4)-induced spermatozoa damage. Methods: Roselle flowers (Hibiscus sabdariffa L.) and bee pollen (Tetragonula laeviceps) were obtained from Bali, Indonesia. A total of 24 BALB/c (Mus musculus) mice were used and randomly assigned into control, negative control (CCl4-induced), positive control (CCl4 + ascorbic acid) and treatment groups (25, 50, and 100 mg/20 g). Spermatozoa-induced damage was done using carbon tetrachloride (CCl4). Sperm levels, movement, viability, and morphology of the spermatozoa we

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Alwan, Iqbal Fadhel, Essam F. Al-Jumaelly, and Amar M. Hamood. "Effect of aqueous extract of Broccoli plant on liver enzymes in laboratory animals treated by carbon tetrachloride." Journal of Biotechnology Research Center 8, no. 4 (2014): 41–46. http://dx.doi.org/10.24126/jobrc.2014.8.4.380.

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The effects of aqueous extracts of broccoli plant against liver enzymes (ALP, ALT,AST,GST) in the laboratory animals treated with carbon tetrachloride were studied. Conducted tests on the overlap between the three concentration 100, 200,300 mg / kgm of aqueous extract of broccoli and 3.2 mg / kgm of carbon tetrachloride with interaction included two types of treatment (pre- ccl4 and post-ccl4) through oral dosage and for a period of 7 days. The study shows that the concentration 300mg / kgm is the best concentration of aqueous extract there was used and study suggests that use the concentratio

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Chao, Jung, Meng-Shiou Lee, Sakae Amagaya, et al. "Hepatoprotective Effect ofShidagonglaoon Acute Liver Injury Induced by Carbon Tetrachloride." American Journal of Chinese Medicine 37, no. 06 (2009): 1085–97. http://dx.doi.org/10.1142/s0192415x0900751x.

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This study investigates the hepatoprotective activity of ethanol extract from Shidagonglao roots (SDGLEtOH). The hepatoprotective effect of SDGLEtOH(20, 100 and 500 mg/kg) was analyzed on carbon tetrachloride ( CCl4)-induced acute liver injury. Rats pretreated orally with SDGLEtOH(100 and 500 mg/kg) and silymarin (200 mg/kg) for 3 consecutive days prior to the administration of a single dose of 50% CCl4(0.10 ml/100 g of bw, ip) significantly prevented the increases in the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl4-treated rats. Histological

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Junnila, M., T. Rahko, A. Sukura, and L. A. Lindberg. "Reduction of Carbon Tetrachloride-Induced Hepatotoxic Effects by Oral Administration of Betaine in Male Han-Wistar Rats: A Morphometric Histological Study." Veterinary Pathology 37, no. 3 (2000): 231–38. http://dx.doi.org/10.1354/vp.37-3-231.

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Eighty-five male Han-Wistar rats were arranged into three groups: CCl4-exposed rats, CCl4 + betaine-exposed rats, and control rats. To see the effect of betaine alone, five rats of the control and of the CCl4 + betaine groups were sacrificed after 7 days, before exposure to CCl4. After that, two of the groups (the CCl4 and CCl4 + betaine groups) were exposed to CCl4 (1 ml/kg per day subcutaneously [SC] for 4 consecutive days), and one of the groups (control group) was given olive oil (1 ml/kg per day SC for 4 consecutive days). At the start of the study (day 0), day 1, day 2, day 3, day 4, and

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VURAL, Duygu Fevziye, Hatice MUTLU EYİSON, Dilşad ÖZERKAN, and Suna CEBESOY. "The effect of melatonin on rat soleus muscle treated with carbon tetrachloride." Communications Faculty of Science University of Ankara Series C Biology Geological Engineering and Geophysical Engineering 31, no. 2 (2022): 165–76. http://dx.doi.org/10.53447/communc.1178452.

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Antioxidants are known to restrains various tissue damage caused by the administration of carbon tetrachloride (CCl4). This study examined whether melatonin (MEL), a molecule known to have antioxidant properties, has a protective effect on the rat soleus muscle, where toxic damage is caused by the application of CCl4. In the study, eighteen albino-type male Wistar rats were used and divided into three groups as Control Group (group 1), CCl4 group (group 2) and CCl4 + MEL group (group 3). End of the 12 weeks, blood samples were taken as intracardiac from the rats under ketamine/rompun anesthesi

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Elbaky, Nayira A. Abd, Naglaa F. El-Orabi, Laila M. Fadda, Omar H. Abd-Elkader, and Hanaa M. Ali. "Role of N-Acetylcysteine and Coenzyme Q10 in the Amelioration of Myocardial Energy Expenditure and Oxidative Stress, Induced by Carbon Tetrachloride Intoxication in Rats." Dose-Response 16, no. 3 (2018): 155932581879015. http://dx.doi.org/10.1177/1559325818790158.

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This study is designed to evaluate the potential impact of N-acetyl cysteine (NAC) and coenzyme Q10 (CoQ10) each alone or in combination against carbon tetrachloride (CCl4)-induced cardiac damage in rats. Animals were treated with CCl4 in single intraperitoneal dose of 1 mL/Kg body weight; CCl4-intoxicated animals were pretreated with 20 mg/kg/d NAC or pretreated with 200 mg/kg/d CoQ10 or NAC and CoQ10 with the same previously mentioned doses. Carbon tetrachloride–intoxicated rats showed a significant elevation in nitric oxide and lipid peroxides and downregulation in reduced glutathione level

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DEULOFEU, Ramón, Albert PARÉS, Mireia RUBIO, et al. "S-Adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats." Clinical Science 99, no. 4 (2000): 315–20. http://dx.doi.org/10.1042/cs0990315.

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In various experimental models, S-adenosylmethionine (SAMe) has been shown to reduce liver injury by preventing depletion of glutathione, one of the antioxidant systems that plays a critical role in defence against oxidative stress. On the other hand, α-tocopherol may be decreased in liver diseases, and treatment with this vitamin reduces liver injury in CCl4-treated rats. Since there is a close relationship among the different antioxidant systems (mainly glutathione, α-tocopherol and ascorbic acid), we have assessed whether, as well as restoring hepatic glutathione content, SAMe has any effec

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Wu, Yueh-Wern, Kuan-Dee Chen, and Wen-Chuan Lin. "Effect ofGanoderma tsugaeon Chronically Carbon Tetrachloride-Intoxicated Rats." American Journal of Chinese Medicine 32, no. 06 (2004): 841–50. http://dx.doi.org/10.1142/s0192415x04002454.

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The purpose of this study was to evaluate the hepatoprotective and anti-fibrotic actions of crude extracts of Ganoderma tsugae (GTE) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received GTE through the whole experimental period. GTE showed obvious reducing actions on the elevated levels of glutamate-oxalate-transaminase (GOT) and glutamate-pyruvate-transaminase (GPT) caused by CCl4at weeks 3, 6 and 8. Liver fibrosis in rats induced by CCl4led to the drop of serum albumin and hepatic protein conce

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Awaliah Sifa, Nurharija, Husnarika Febriani, and Leni Widiarti. "PENGARUH PEMBERIAN EKSTRAK ETANOL BUAH AREN (Arenga pinnata Merr.) TERHADAP KADAR KREATININ, UREUM DAN HISTOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4)." Jurnal Biogenerasi 10, no. 2 (2025): 1173–81. https://doi.org/10.30605/biogenerasi.v10i2.5637.

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One substance that produces radical compounds is carbon tetrachloride (CCl4). As a solvent, insecticide, coolant, stain remover, and soap, carbon tetrachloride is widely used. Direct skin contact, ingestion, inhalation, and eye contact are ways this material enters the body. The antioxidants found in palm fruit (Arenga pinnata Merr.) can help protect against damage caused by free radicals. This study aims to determine how giving ethanol extract of palm fruit (Arenga pinnata Merr.) to white rats (Rattus norvegicus L.) affects creatinine, urea levels and kidney histology when exposed to carbon t

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Hussein, Mohamed, and Rawoof Khan. "CCL4-Induced Hepatotoxicity: Study in Rats Intoxicated with Carbon Tetrachloride and Treated with Camel Milk and Urine." Journal of Chemistry Studies 1, no. 1 (2022): 07–11. http://dx.doi.org/10.32996/jcs.2022.1.1.2.

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The liver is responsible for the metabolism and detoxification of the most of components that enter the body. Carbon tetrachloride (CCl4) is a highly toxic chemical agent, the most famous drug used to induce liver damage experimentally. Camel milk has been deeply studied for its special properties because of its higher hepatoprotective, insulin and antibacterial activities. The present study was designed to examine the preventive effects of camel milk (CM) and camel urine against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the liver tissue of mice. Administration of a

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Ferrara, Roberta, Michela Rezzadore, Stefano Cazzaro, Roberto Tolando, and Maurizio Manno. "Reductive Activation of Carbon Tetrachloride by Human Haemoglobin." Alternatives to Laboratory Animals 21, no. 1 (1993): 57–64. http://dx.doi.org/10.1177/026119299302100110.

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The reductive metabolism of carbon tetrachloride (CC14) by human haemoglobin (Hb) was observed in vitro by absolute absorption spectra recorded under anaerobic conditions. The following results were obtained: 1) a decrease of the 430nm peak typical of free reduced Hb (Hb2+); 2) the formation of a shoulder of absorbance, attributable to the production of a complex between Hb2+ and a metabolite of CC14 carbon monoxide (Hb-CO); and 3) the oxidation of some Hb2+ to methaemoglobin (Hb3+). The concentration of these three forms — Hb2+, Hb-CO and Hb3+ — during anaerobic incubation of Hb with CC14 was

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Elmubarak, SMEO, and N. Özsoy. "Histoprotective effect of vitamin D against carbon tetrachloride nephrotoxicity in rats." Human & Experimental Toxicology 35, no. 7 (2015): 713–23. http://dx.doi.org/10.1177/0960327115598387.

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This study investigated the protective effect of vitamin D against carbon tetrachloride (CCl4)-induced nephrotoxicity in rats. Adult male Wistar albino rats were divided into four groups ((A) control; (B) 10-week exposure to CCl4; (C) 10-week exposure to CCl4 + vitamin D treatment; and (D) 10-week exposure to CCl4 + 12 weeks of vitamin D treatment). The CCl4 dose (1.5 ml kg−1) was injected subcutaneously twice a week, while the 0.5 mg kg−1 dose of vitamin D was administered intraperitoneally every day, as appropriate for each group. Whole animal and kidney weights as well as serum urea, creati

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Vidyadhar, Kamshetti Manoj, and Hemant Kumar Sharma. "Hepatoprotective Effect of Tagetes Erecta L. Extract on Carbon Tetrachloride Induced Hepatotoxicity in Rats." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 269–72. http://dx.doi.org/10.22270/jddt.v9i4-s.3316.

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Tagetes erecta L. is a widespread garden plant that is commonly known as the marigold, and it is widely used as a medicinal herb for its anti-inflammatory, analgesic, and anti-edematous properties, which are important for phytotherapeutic, dermatological and cosmetic applications. In this study, the protective effects of water extract of Tagetes erecta L. against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. The results showed that the treatment of extract significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GP

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Xiao, X., R. G. Prinn, P. J. Fraser, et al. "Atmospheric three-dimensional inverse modeling of regional industrial emissions and global oceanic uptake of carbon tetrachloride." Atmospheric Chemistry and Physics Discussions 10, no. 5 (2010): 12225–60. http://dx.doi.org/10.5194/acpd-10-12225-2010.

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Abstract. Carbon tetrachloride (CCl4) has substantial stratospheric ozone depletion potential and its consumption is controlled under the Montreal Protocol and its amendments. We implement a Kalman filter using atmospheric CC14 measurements and a 3-dimensional chemical transport model to estimate the interannual regional industrial emissions and seasonal global oceanic uptake of CCl4 for the period of 1996–2004. The Model of Atmospheric Transport and Chemistry (MATCH), driven by offline National Center for Environmental Prediction (NCEP) reanalysis meteorological fields, is used to simulate CC

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Wong, Leo Lap Yan, Sheung Tat Fan, Kwan Man, et al. "Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity." Human & Experimental Toxicology 30, no. 9 (2010): 1369–81. http://dx.doi.org/10.1177/0960327110391388.

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Carbon tetrachloride (CCl4) is a common hepatotoxin used in experimental models to elicit liver injury. To identify the proteins involved in CCl4-induced hepatotoxicity, two-dimensional gel electrophoresis was employed followed by mass spectrometry - mass spectrometry (MS/MS) to study the differentially expressed proteins during CCl4 exposure in the Fischer 344 rat liver proteome for 5 weeks. Ten spots with notable changes between the Control and CCl4 groups were successfully identified. Among them, four proteins with significant up-regulation, namely calcium-binding protein 1, protein disulfi

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Boll, Meinrad, Lutz W. D. Weber, Eberhard Becker, and Andreas Stampfl. "Hepatocyte Damage Induced by Carbon Tetrachloride: Inhibited Lipoprotein Secretion and Changed Lipoprotein Composition." Zeitschrift für Naturforschung C 56, no. 3-4 (2001): 283–90. http://dx.doi.org/10.1515/znc-2001-3-419.

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AbstractChanges of lipoprotein secretion and composition in response to CCl4 treatment were studied in monolayer cultures of rat primary hepatocytes. (1) CCl4 decreased secretion of very low density lipoproteins (VLDL) by about 85%, while high density lipoprotein (HDL) secretion was less affected (about 40%). The effect was concentration-dependent. (2) CCl4 significantly inhibited secretion of VLDL-and HDL-associated triglycerides and cholesterol esters. VLDL-and HDL-associated cholesterol was not affected, while secretion of phospholipids was increased. (3) Hepatocytes secreted the apolipopro

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Pergel, A., L. Tümkaya, MK Çolakoğlu, et al. "Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis." Human & Experimental Toxicology 38, no. 11 (2019): 1275–82. http://dx.doi.org/10.1177/0960327119867758.

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Carbon tetrachloride (CCL4) is often employed in the production of chlorofluorocarbons, petroleum refining, oil and rubber processing, and laboratory applications. Oral, subcutaneous, and inhalation exposure to CCL4 in animal studies have been shown to be capable of leading to various types of cancer (benign and malignant, liver, breast, and adrenal gland tumors). The present study also evaluated the protective role of infliximab (INF) against the deleterious effects of CCL4 on the intestinal system. Twenty-four male Sprague-Dawley rats were randomly assigned into three groups, control ( n = 8

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Towner, Rheal A., Lester A. Reinke, Edward G. Janzen, and Shigeto Yamashiro. "In vivo magnetic resonance imaging study of Kupffer cell involvement in CCl4-induced hepatotoxicity in rats." Canadian Journal of Physiology and Pharmacology 72, no. 5 (1994): 441–46. http://dx.doi.org/10.1139/y94-064.

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When carbon tetrachloride (CCl4) was administered to rats, a localized region of hepatic edema could be detected within 1 h by in vivo proton magnetic resonance imaging. However, if rats were pretreated with gadolinium chloride (GdCl3), an inhibitor of Kupffer cell function, the CCl4-induced edema was greatly decreased. Methyl palmitate, another Kupffer cell inhibitor, also decreased the degree of edema caused by the administration of CCl4. Electron micrographs of samples that were taken from regions of the liver where the edema was localized indicated formation of vacuoles and lipid droplets

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Aamir, Shabnum, Zia Ud Din, Shahab Ud Din, Muhammad Junaid, Falak Naz, and Zainab Rehman. "EFFECT OF VITAMIN E ON CHEMICALLY INDUCED HEPATIC FATTY DEGENERATION AND PORTAL INFLAMMATION IN ALBINO." Khyber Journal Of Medical Sciences 14, no. 1 (2021): 8–12. https://doi.org/10.70520/kjms.v14i1.109.

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Objectives: To determine the antioxidant effect of vitamin E against carbon tetrachloride (CCl4) induced fatty degeneration and portal inflammation in the liver of albino mice. Study design: Analytical experimental study. This study was performed on different groups of albino mice to determine the antioxidant effect of vitamin E against carbon tetrachloride (CCl4) induced fatty degeneration and portal inflammation in the liver. The study duration was 5 months. The animals were randomly distributed into five groups A, B, C, D and E .The group A served as control group, group B was administered

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Tomasi, A., E. Albano, S. Banni, et al. "Free-radical metabolism of carbon tetrachloride in rat liver mitochondria. A study of the mechanism of activation." Biochemical Journal 246, no. 2 (1987): 313–17. http://dx.doi.org/10.1042/bj2460313.

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Alterations in liver mitochondria as consequence of rat poisoning with carbon tetrachloride (CCl4) have been reported over many years, but the mechanisms responsible for causing such damage are still largely unknown. Isolated rat liver mitochondria incubated under hypoxic conditions with succinate and ADP were found able to activate CCl4 to a free-radical species identified as trichloromethyl free radical (CCl3) by e.s.r. spectroscopy coupled with the spin-trapping technique. The incubation of mitochondria in air decreased free-radical production, indicating that a reductive reaction was invol

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Almohmadi, Najlaa, Ahmed Aldhalmi, Mona Zahran, et al. "Hepatoprotective efficacy of Lagenaria siceraria seeds oil against experimentally carbon tetrachloride-induced toxicity." Open Veterinary Journal 14, no. 8 (2024): 2016. http://dx.doi.org/10.5455/ovj.2024.v14.i8.31.

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Background: The liver is crucial for maintaining normal metabolism in the body. Various substances, such as toxic chemicals, drugs, and alcohol, can damage hepatocyte cells, leading to metabolic imbalances. Aim: The experiment aimed to determine the efficacy of Lagenaria siceraria seed oil (LSS) as a hepatoprotective agent against acute hepatotoxicity triggered by carbon tetrachloride (CCl4). Methods: A total of 20 rats were randomly separated into four groups. The control group: rats received 2 ml of distilled water orally, followed by 1.25 ml of olive oil intraperitoneally (i.p.) after 30 mi

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Mendoza, Y., K. D. Goodwin, and J. D. Happell. "Microbial Removal of Atmospheric Carbon Tetrachloride in Bulk Aerobic Soils." Applied and Environmental Microbiology 77, no. 17 (2011): 5835–41. http://dx.doi.org/10.1128/aem.05341-11.

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ABSTRACTAtmospheric concentrations of carbon tetrachloride (CCl4) were removed by bulk aerobic soils from tropical, subtropical, and boreal environments. Removal was observed in all tested soil types, indicating that the process was widespread. The flux measured in field chamber experiments was 0.24 ± 0.10 nmol CCl4(m2day)−1(average ± standard deviation [SD];n= 282). Removal of CCl4and removal of methane (CH4) were compared to explore whether the two processes were linked. Removal of both gases was halted in laboratory samples that were autoclaved, dry heated, or incubated in the presence of m

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MacDonald, Idu, Ovuakporie-Uvo Oghale, Eze Gerald Ikechi, and Okoro Amarachi Orji. "Hepatoprotective potentials of Picralima nitida against in vivo carbon tetrachloride-mediated hepatotoxicity." Journal of Phytopharmacology 5, no. 1 (2016): 6–9. http://dx.doi.org/10.31254/phyto.2016.5102.

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This research aimed at investigating the in vivo Carbon tetrachloride (CCl4)-mediated hepatotoxicity of methanolic seed extract of Picralima nitida (P. nitida) using Wistar rats. Twenty five (25) rats randomly selected into five groups of five animals were used in this research. Group 1 was administered Normal saline (Negative control); Group II was administered 1 ml of Carbon tetrachloride only (Positive control/ Reference drug); Group III, IV and V got 10 ml P. nitida extract + 1ml Carbon tetrachloride; 100 ml P. nitida extract + 1ml Carbon tetrachloride and 1000 ml P. nitida extract + 1ml C

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