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Journal articles on the topic 'Carbopol 931 and 974'

Author: Grafiati

Published: 3 June 2025

Last updated: 20 July 2025

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1

P., Sowjanya P. Aparna Ch.Srilatha M. Ravi Kumar. "FORMULATION AND INVITRO EVALUATION OF TRANSDERMAL GEL CONTAINING KETOPROFEN SILVER NANOPARTICLES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4625–31. https://doi.org/10.5281/zenodo.1257662.

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<em>Ketoprofen</em><em>, (RS)-2-(3-benzoylphenyl)-propionic acid (chemical formula C<sub>16</sub>H<sub>14</sub>O<sub>3</sub>) is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin. In the present research work transdermal gel containing ketoprofen silver nanoparticles were prepared and characterized eight formulations were prepared by using different concentrations of carbopol 931 and 974 various evaluation

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Al-Sakini, Sadeq Jaafar, and Nidhal K. Maraie. "In vitro Evaluation of the Effect of Using Different Gelling agents on the Release of Erythromycin from a Nanocubosomal gel." Al Mustansiriyah Journal of Pharmaceutical Sciences 19, no. 1 (2019): 34–43. http://dx.doi.org/10.32947/ajps.v19i1.542.

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Preparation of a topical gel for erythromycin using optimized nano-sized cubosome dispersion, which is changed into a gel to get nanocubosomal gel using different gelling agents. The optimum nanocubosomal dispersion containing 4.4% glyceryl mono oleate (GMO) (as an oil phase) and 0.6% poloxamer 407 (as an emulsifying agent) was converted into a gel using different gelling agents including carbopol 974, carbopol 940, carbopol 934 and hydroxyl propyl methylcellulose (HPMC) at different ratios of (1:1 and 1:2). Each prepared gel was then evaluated in vitro to determine the homogenisity, con

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3

Abdul, Bari Mohd. "FORMULATION AND INVITRO EVALUATION OF ECONAZOLE NITRATE TOPICAL GEL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 08 (2018): 8136–44. https://doi.org/10.5281/zenodo.1407161.

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<em>In the present work an attempt was being made to formulate and evaluate Topical gel containing anti inflammatory drug Econazole nitrate. Carbopol 971, Guar gum and carbopol 934 were selected as polymers.The drug and excipient compatability was studied by using FTIR Nine formulations of gels were prepared by taking different quantities of polymers. The prepared gel was subjected to various evaluation tests like pH, spreadability, viscosity, content uniformity and diffusion studies conducted upto 12hrs.All the results were with in the limits , by diffusion studies it was observed that formul

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Kawkab, Mohammed and Abdul Bari Mohd. "FORMULATION AND INVITRO EVALUATION OF TAZAROTENE TOPICAL GEL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 02 (2019): 4003–12. https://doi.org/10.5281/zenodo.2565304.

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<em>Tazarotene is a member of the acetylenic class of retinoids. This medication is approved for treatment of psoriasis, acne, and sun damaged skin .In the present work an attempt was being made to formulate and evaluate topical gel containing antipsoriatics drug </em><em>Tazarotene</em><em>. Carbopol 971, </em><em>Sodium CMC </em><em>and carbopol 934 were selected as polymers.The drug and excipient compatability was studied by using FTIR Nine formulations of gels were prepared by taking different quantities of polymers</em><em> .</em><em>The prepared gel was subjected to variou

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5

FALAHI, ASA. "PENGARUH VARIASI KONSENTRASI CARBOPOL 934 SEBAGAI PENGENTAL TERHADAP SIFAT FISIK SEDIAAN SAMPO INFUSA DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.)." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 5, no. 1 (2022): 24–30. http://dx.doi.org/10.53864/jifakfar.v5i1.104.

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The purpose of this study was to determine the effect of variation concentration carbopol 934 934 to the characteristics of physical shampoo from anti-dandruff infusion of pandan leaves (Pandanus amaryllifolius roxb). Pre-experiment one shot case study was used as a research design. Variation in carbopol 934 concentration were 1% (F1), 1.5% (F2), and 2% (F3) The result stowed that variation concentration of carbopol 934 affect organoleptic shape and smell, pH, and viscosity of shampoo. But didn’t affect color, homogenity, and foam height oh shampoo. The viscosity of the shampoo increases with

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FALAHI, ASA. "PENGARUH VARIASI KONSENTRASI CARBOPOL 934 SEBAGAI PENGENTAL TERHADAP SIFAT FISIK SEDIAAN SAMPO INFUSA DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.)." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 5, no. 1 (2022): 24–30. http://dx.doi.org/10.53864/jifakfar.v5i1.114.

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The purpose of this study was to determine the effect of variation concentration carbopol 934 934 to the characteristics of physical shampoo from anti-dandruff infusion of pandan leaves (Pandanus amaryllifolius roxb). Pre-experiment one shot case study was used as a research design. Variation in carbopol 934 concentration were 1% (F1), 1.5% (F2), and 2% (F3) The result stowed that variation concentration of carbopol 934 affect organoleptic shape and smell, pH, and viscosity of shampoo. But didn’t affect color, homogenity, and foam height oh shampoo. The viscosity of the shampoo increases with

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7

Kumar, Manish. "Development and Evaluation of Transdermal Gel for Pain Relief." Frontiers in Scientific Research & Artificial Intelligence 1, no. 1 (2023): 1–6. http://dx.doi.org/10.31531/fsrai.1000102.

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The study was to develop transdermal gel formulations for the delivery of aspirin and paracetamol. Compared to more conventional approaches like oral, injectable, and inhaler administration, transdermal medication delivery through the skin has a number of benefits. These benefits include self-administering simplicity, non-intrusiveness, usability, cost, and the capacity to maintain sustained plasma drug concentrations over prolonged periods of time. Two polymers in creating transdermal gels Carbopol-934 and Sodium Alginate were assessed. Carbopol-934 was chosen because of its capacity to impro

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Sana, Nusrat Praween* Sallikim Sangma Tanya Sharma Pankaj Chasta. "Current Insights and Future Directions of Mesenchymal Stem Cell Therapy for Knee Osteoarthritis." International Journal of Pharmaceutical Sciences 2 (December 22, 2024): 2828–52. https://doi.org/10.5281/zenodo.14542927.

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Among the most recent developments in Skillful DDS, gel allows for the dual control of the emulsion's and gel's appearance, making it ideal for a variety of practical applications. Accuracy standards: An oil sorting device utilizing liquid paraffin and propylene glycol, a surfactant consisting of Tween 80 and arrive at 80, and the utilization of pseudo ternary coordinate graphs were utilized in the development of this smaller-than-common emulsion w/o. Using a variety of methods, the high-level emulsion orchestrate was mixed into the gel mixture containing Carbopol-934, HPMC-5, and HPMC15+ Carb

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Anchal Dwivedi, Shriyanshi Singh Rana, Vishal Dubey, Megha Tiwari, Mayur Porwal, and Anita Devi. "Formulation and Evaluation of ACNE Gel using Metronidazole and Doxycycline." Journal of Advanced Zoology 44, S6 (2023): 72–79. http://dx.doi.org/10.17762/jaz.v44is6.1986.

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This research study focuses on the formulation and evaluation of an ACNE gel using Metronidazole (1%) and Doxycycline (0.5%) as active ingredients. Three types of polymers, Hydroxypropyl Methylcellulose (HPMC), Carbopol 940, and Carbopol 934 were used for gel formation. The formulated gels were evaluated for their physical characteristics, in vitro drug release, and drug-polymer compatibility. The calibration curves for both Metronidazole and Doxycycline displayed strong linearity within the concentration range of 5 to 25 µg/mL, facilitating accurate drug quantification. The gel formulations e

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M.Sudharshan, M. Sudharshan, Dr S. K. Senthil Kumar, M. Anandhi M.Anandhi, et al. "Formulation and Evaluation of Fenugreek Gel as a Topical AntiInflammatory Agent." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1151–53. https://doi.org/10.35629/4494-100111511153.

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This study focused on the development and evaluation of a topical gel containing Trigonella foenumgreacum seed extract, formulated with carbopol-934 and HPMC K4M as gelling agents, to explore its anti-inflammatory potential. Gel formulations containing carbopol-934 and HPMC K4M were prepared, evaluated for their physicochemical properties, and subjected to in vitro permeation studies to determine the optimal formulation. The gel formulation prepared with a combination of carbopol-934 and HPMC K4M demonstrated the highest drug release rate, with 88.02±0.06% of the drug released after 8 hours in

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Amalia, Anisa, Fith Khaira Nursal, Nining Nining, Tahyatul Bariroh, Andra Yunita Laszairina, and Adelia Dinaianti. "Formulasi Sabun Gel Ekstrak Biji Manjakani Menggunakan Tragakan dan Carbopol 934 sebagai Gelling Agent." Indonesian Journal of Pharmaceutical Science and Technology 11, no. 1 (2024): 101–8. http://dx.doi.org/10.24198/ijpst.v11i1.45499.

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Biji manjakani (Quercus infectoria) dapat digunakan sebagai bahan aktif pada sediaan sabun pembersih kewanitaan karena mengandung senyawa tannin yang dapat menghambat pertumbuhan jamur Candida albicans. Tragakan dan carbopol 934 merupakan gelling agent yang dapat digunakan pada pembuatan sabun gel. Tujuan penelitian ini adalah untuk mengetahui pengaruh perbedaan jenis dan konsentrasi gelling agent terhadap stabilitas fisik sabun gel pembersih kewanitaan ekstrak etanol 96% biji manjakani. Formula 1 - 4 menggunakan tragakan pada konsentrasi 0,5% (F1), 1% (F2), 1,5% (F3), dan 2% (F4). Formula 5 -

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Bandameedi, Ramu, and Shanmunga Pandiyan P. "FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING BIOADHESIVE TABLETS OF HYDROCHLORTHIAZIDE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 150. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.17137.

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Objective: Floating bioadhesive tablets of hydrochlorothiazide were developed to prolong gastric residence time leading to an increase in drugbioavailability where here a combination of floating and bioadhesion mechanism is combined.Methods: Tablets are prepared by direct compression technique using polymers xanthan gum, carbopol 974 P, HPMC K15M, HPMC K100M, magnesiumStearate USP-NF (Avicel PH 102), microcrystalline cellulose Ph 102, Talc, and sodium bicarbonate.Results: Tablets were evaluated for their physical characteristics, namely, hardness, thickness, friability and weight variation, dr

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13

Sahoo, Subhashree, ChandraKanti Chakraborti, and SubashChandra Mishra. "Qualitative analysis of controlled release ciprofloxacin/carbopol 934 mucoadhesive suspension." Journal of Advanced Pharmaceutical Technology & Research 2, no. 3 (2011): 195. http://dx.doi.org/10.4103/2231-4040.85541.

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14

Vila-Jato, JoséL, Angel Concheiro, Begoña Seijo, and Begoña Viana. "Aging of nitrofurantoin tablets containing Carbopol 934 as a binder." International Journal of Pharmaceutics 30, no. 2-3 (1986): 229–36. http://dx.doi.org/10.1016/0378-5173(86)90084-0.

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15

Gómez-Carracedo, A., C. Alvarez-Lorenzo, J. L. Gómez-Amoza, R. Martínez-Pacheco, C. Souto, and A. Concheiro. "Extrusion-Spheronization of Blends of Carbopol 934 and Microcrystalline Cellulose." Drug Development and Industrial Pharmacy 27, no. 5 (2001): 381–91. http://dx.doi.org/10.1081/ddc-100104313.

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16

Verma, Ribha, Ramakant Lamichhane, and Joshna Shrestha. "Formulation & In Vitro Evaluation of Effect of Polymer in Gastro-Retentive Drug Delivery System Using Ciprofloxacin Hydrochloride as A Model Drug." Dinkum Journal of Medical Innovations 3, no. 03 (2024): 271–89. https://doi.org/10.71017/djmi.3.3.d-0268.

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Gastro-retentive dosage form offer many advantages having absorption from upper gastrointestinal tract and improve the bioavailability of medications that are characterized by a narrow absorption window. A new gastro-retentive floating drug delivery system was developed for ciprofloxacin preferably once daily. The design of the delivery system was based on the sustained release formulation with floating and swelling features in order to prolong the gastric retention time of the drug delivery system. Final formulations were prepared and optimized by Box-Behnken design by using HPMC K100M and Ca

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Vasudev, Jitendra Sharma* Mayur Gokul Jayswal Raza Khan Dr. Mohd. Rehan Deshmukh Prof. (Dr.) G. J. Khan. "Formulation And Evaluation of Gel Containing Zinc Oxide Nanoparticle of Ketoconazole With Aqueous Honey Solution." International Journal in Pharmaceutical Sciences 1, no. 10 (2023): 44–53. https://doi.org/10.5281/zenodo.8419318.

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The aim and objective of the present study was to formulate and evaluate Ketoconazole Nanoparticle. Prepared Ketoconazole loaded zinc oxide nanoparticle. The prepared Nanoparticle formulation was evaluated for particle size and Polydispersity index. The prepared Nanoparticle further formulation gel was prepared with Carbopol 934 and Carbopol 940 Polymers. The honey used as antimicrobial and antifungal agent. The prepared Formulation was evaluated Drug content, viscosity. Spreadability, pH, In vitro Drug release study and Stability studies, antifungal activity. Particle size analysis showed tha

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Gopikrishna, Addanki, B. Ramu, G. Srikanth, and Bigala Rajkamal. "Formulation of Isoniazide Sustained Release Formulation by Using Carbopol 934 P." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 1, no. 02 (2016): 60–69. http://dx.doi.org/10.21477/ijapsr.v1i2.10177.

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The aim of the present study was to develop sustained release formulation of Isoniazide to maintain constant therapeutic levels of the drug for over 12 hrs. Various polymers such as Guar gum, HPMCK100 M, PEG 6000 and Carbopol 934 p were employed as polymers. Isoniazide dose was fixed as 100 mg. Total weight of the tablet was considered as 400 mg. Polymers were used in the concentration of 100, 150 and 200 mg. All the formulations passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation

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Morrin, Mary, and Owen P. Ward. "Studies on interaction of Carbopol-934 with hyphae of Rhizopus arrhizus." Mycological Research 92, no. 3 (1989): 265–72. http://dx.doi.org/10.1016/s0953-7562(89)80064-4.

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20

G. Munshi, Azima, Manish Goyani, and Meghraj V. Suryawanshi. "FORMULATION AND DEVELOPMENT OF LONG-ACTING THERMOSENSITIVE AND MUCOADHESIVE VAGINAL GEL OF METRONIDAZOLE." Indian Drugs 60, no. 06 (2023): 34–41. http://dx.doi.org/10.53879/id.60.06.13069.

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The development of an in situ metronidazole gel that is mucoadhesive and thermo sensitive was the aim of this study in the fight against bacterial vaginosis. Numerous evaluation criteria have been carried out, including mucoadhesive force, pH, viscosity, syringe capability, medication content, gelation temperature, and gelation time. All of the solutions were found to have pH values between 6-7. The viscosity was correlated with the mucoadhesive force. The drug release parameter indicates that in situ gels containing Carbopol 934 provide superior drug release compared to other polymers. Additi

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Kadhium, Huda S., and Nidhal K. Maraie. "Efficacy of Gelling Agents on the In-vitro Release and Physical Properties of Loxoprofen Sodium Gel Containing Ultra Elastic Vesicles." International Journal of Drug Delivery Technology 9, no. 04 (2019): 671–77. http://dx.doi.org/10.25258/ijddt.9.4.26.

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Objective: Preparation of a topical prolong release gel for loxoprofen sodium using optimized nano-sized transfersome dispersion using different gelling agents with in vitro and in vivo evaluation in comparison to the marketed gel prepared by a conventional method. Method: The optimum nano transfersome dispersion containing 5% egg lecithin (as an oil phase) 1% span 60 (as an emulsifying agent) was converted into a gel using different gelling agents including carbopol 974p, carbopol 940, carbopol 934 and hydroxyl propyl methylcellulose (HPMC K100) at ratio of (1:1). Each prepared gel was then e

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Parmar, Nilesh, Ramakant Sharma, Jeevan Patel, Shabnam Khan, and Rakesh Patel. "FORMULATION AND EVALUATION STUDIES OF VALACYCLOVIR TOPICAL GEL FOR ANTIVIRAL ACTIVITY." International Journal of Pharmaceutical Sciences and Medicine 7, no. 10 (2022): 97–118. http://dx.doi.org/10.47760/ijpsm.2022.v07i10.006.

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The present work describes a study on Formulation and Evaluation studies of Valacyclovir topical gels for Antiviral activity. Valacyclovir is a broad spectrum antiviral agent against Herpes Simplex Virus and Varicella Zoster Virus, which is specific to viral-infected cells with low toxicity and which is less toxic than earlier generation of antiviral agents and as such represents a major therapeutic advance. This drug was selected for the study because it has good percutaneous absorption and appears to be more active as antiviral activity and is well tolerated. The polymers namely Carbopol-934

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Arora, Shivani, Khusi Chouksey, Trapti Shrivastava, and Kuldeep Ganju. "Formulation and Characterization of Intranasal Mucoadhesive Gel of Antiallergic Drug Loratadine for Improved Bioavailability." Journal of Drug Delivery and Therapeutics 15, no. 1 (2025): 67–72. https://doi.org/10.22270/jddt.v15i1.6952.

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The present study aimed to formulate and characterize an intranasal mucoadhesive gel of loratadine to enhance its bioavailability. Loratadine, an antihistamine, is commonly used for the treatment of allergic conditions, but its low bioavailability due to extensive first-pass metabolism can limit its effectiveness. To address this issue, an in situ gel formulation was developed using Poloxamer 407 and Carbopol 934 as excipients. The gel's physicochemical properties, including pH, drug content, viscosity, gel strength, gelation temperature, and drug release profile, were evaluated. FT-IR analysi

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Afifah, Hani, and Setyo Nurwaini. "Uji Aktivitas Antijamur Gel Serbuk Lidah Buaya (Aloe vera L.) Berbasis Carbopol 934 Terhadap Candida albicans dan Trichophyton mentagrophytes." Pharmacon: Jurnal Farmasi Indonesia 15, no. 2 (2019): 42–51. http://dx.doi.org/10.23917/pharmacon.v15i2.7658.

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Fungal infections that occur in the skin and nails were caused by fungi such as Candida albicans and Trichophyton mentagrophytes. Aloe vera contains saponins and acemannan that were effective as an antifungal. This study aims to determine the effect of carbopol concentration variation on aloe vera gel to antifungal activity of Candida albicans and Trichophyton mentagrophytes.Aloe vera powder was obtained from freeze drying aloe vera juice which had been frozen. Aloe vera powder was formulated in gel form using carbopol base with concentration 0.5; 1.0; 1.5; and 2.0 %w/w. The aloe vera gel was

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Saiyed, Selim Ali* Pintu Kumar De Himangshu Maji. "Development and Assessment of Aceclofenac Gel-Based Topical Formula." International Journal of Scientific Research and Technology 2, no. 2 (2025): 115–24. https://doi.org/10.5281/zenodo.14873940.

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Emulgel is an advanced drug delivery system that combines emulsion and gel for controlled topical release. Incorporating emulsion into a gel base enhances stability. Aceclofenac, a non-steroidal anti-inflammatory drug, is widely used for rheumatoid arthritis and osteoarthritis. This study aimed to develop and assess an aceclofenac emulgel to improve skin penetration compared to existing formulations. Five gelling agents—Carbopol 934, HPMC, Na CMC, and sodium alginate—were used. Drug release was tested via dialysis membrane, with all formulations exhibiting good physical properties.

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Vtla-Jato, Jose L., Angel Concheiro, and Begoña Seijo. "Effect of Aging on the Bioavailability of Nitrdfurantoin Tablets Containing Carbopol 934." Drug Development and Industrial Pharmacy 13, no. 8 (1987): 1315–27. http://dx.doi.org/10.3109/03639048709068378.

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Genç, Lütfi, and A. Kıran. "In Vitro Evaluation of Sustained Released Matrix Tablet Formulations of Clarithromvcin." Scientia Pharmaceutica 73, no. 1 (2005): 59–74. http://dx.doi.org/10.3797/scipharm.aut-05-05.

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Sustained release matrix tablets of clarithromycin were prepared using different polymers as Hydroxypropyl methylcellulose (H PMC), Carbopol 934 and Eudragit RL/PO by direct compression technique. For the quality control of these formulations, weight deviation, hardness, friability, diameter-height ratio, content uniformity of the active substance and in vitro dissolution technique were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. Dissolution profiles of the tablets were plotted and evaluated kinetically. The effects on drug release of polymer ty

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Syed abid ali, Syed mujtaba pasha, Omair sohail ahmed, et al. "Formulation and invitro evaluation of oral extended release microspheres of aceclofenac using various natural polymers." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 2 (2019): 58–66. http://dx.doi.org/10.33974/ijrpst.v1i2.69.

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In the present work, bioadhesive microspheres of Aceclofenac using Sodium alginate along with Carbopol 934, Carbopol 971, HPMC K4M as copolymers were formulated to deliver Aceclofenac via oral route. The results of this investigation indicate that ionic cross-linking technique Ionotropic gelation method can be successfully employed to fabricate Aceclofenac microspheres. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. FT-IR spectra of the physical mixture revealed that the dru

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Suraj, kothule. "Formulation Development and Evaluation of Gastroretentive Floating Tablet of Vildagliptin." INTERNATIONAL JOURNAL IN PHARMACEUTICAL SCIENCES 1, no. 1 (2021): 21–30. https://doi.org/10.5281/zenodo.5654051.

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The present study was an attempt to formulate and evaluate a floating tablet of vildagliptin using polymers such as HPMC K4M, Carbopol 934, NaHCO3, and citric acid as gas producers. vildagliptin, an antidiabetic drug with 85% oral bioavailability, short half-life (1.5 hours) and largely associated with an acidic pH, is believed to increase gastric survival and therapeutic efficacy. This can be achieved by making floating pills that stay in the stomach for a long time to release the drug. The tablets are formulated using the direct compression method. The effects of sodium bicarbonate and citri

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Kashid, Pooja, Rajendra Doijad, Amol Shete, Sachin Sajane, and Abhimanyu Bhagat. "Studies on Rebamipide Loaded Gastroretentive Alginate Based Mucoadhesive Beads: Formulation & In-vitro, In-vivo Evaluation." Pharmaceutical Methods 7, no. 2 (2016): 132–38. https://doi.org/10.5281/zenodo.14856861.

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Introduction: Oral route is the most common and convenient route to deliver the drug. Many oral drug delivery systems were developed to improve drug bio availability; gastro retentive drug delivery system is one of them. Gastroretentive drug delivery system is the system in which a drug can remain in the gastric region for several hours in order to prolong its gastric residence time. The purpose of this work was to develop and evaluate rebamipide loaded gastro retentive alginate based muco adhesive beads. Materials and Methods: Rebamipide loaded alginate beads were prepared by ionotropic gelat

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Shalviri, Alireza, Avinash C. Sharma, Dipak Patel, and Amyn Sayani. "Low-Surfactant Microemulsions for Enhanced Topical Delivery of Poorly Soluble Drugs." Journal of Pharmacy & Pharmaceutical Sciences 14, no. 3 (2011): 315. http://dx.doi.org/10.18433/j38p4v.

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Purpose: To develop and characterize low-surfactant microemulsion (ME) gels to enhance topical delivery of poorly soluble drugs. Method: Five low surfactant ME formulations were manufactured following the construction of pseudo-ternary phase diagrams. The MEs were screened for their ability to dissolve a poorly soluble new chemical entity (Model Drug X). Various viscosity imparting agents like Carbopol 934, Colloidal Silica, HPMC K100M, Lubrajel NP, and Xanthan Gum were evaluated for the manufacture of these ME gels. Each ME gel was then further evaluated for physical stability, including asse

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Wahyuni, Indah Suasani, Irna Sufiawati, Amira Shafuria, Wipawee Nittayananta, and Jutti Levita. "Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract." Pharmaceutics 16, no. 3 (2024): 421. http://dx.doi.org/10.3390/pharmaceutics16030421.

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The rhizome of Kaempferia galanga (Zingiberaceae) is extensively used in traditional medicine by utilizing its various biological activities. It has been proven that ethyl-para-methoxycinnamate (EPMC) and other polyphenolic compounds are present in considerable amounts in the ethanolic extract of K. galanga rhizome (EKG). Our previous study confirmed that a dose of 0.5–1% of EKG demonstrated anti-inflammatory activity and a wound-healing effect in chemical-induced oral mucosal ulcers of Wistar rats. Currently, there are no reports on the formulation of oral gel containing EKG, thus revealing t

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Garge, Lajri, and Ravindranath B. Saudagar. "Development and Characterization of In Situ Ophthalmic Gel of Bepotastine Besilate." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 656–63. http://dx.doi.org/10.22270/jddt.v9i4-a.3547.

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The aim of the present work was development and characterization of in-situ Ophthalmic Gel of Bepotastine Besilate to overcome the drawbacks obtained by conventional eye drop. There are two independent variables were used i.e. Carbopol 934 and HPMC K100. Carbopol 934 were used as gelling agent and HPMC K100 were used as bioadhesive polymer. The in situ gelling system involves sol-to-gel transition in the cul-de-sac upon instillation to avoid pre corneal elimination. The formulations were prepared by 32 factorial design. The prepared formulations were evaluated for Clarity, pH, Viscosity, Bioad

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Toskic-Radojcic, Marija, Marija Pavlovic, Emilija Gazikalovic, Aleksandra Arandjelovic, and Aleksandra Kovacevic. "A comparative analysis of the influence of different types of Carbopol® on the release rate of lithium-carbonate from matrix tablets." Vojnosanitetski pregled 69, no. 8 (2012): 675–80. http://dx.doi.org/10.2298/vsp101015006t.

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Background/Aim. Hydrophilic matrix tablets represent the most commonly used oral dosage form. Carbomers used in the concentration of 10%-30% for preparation of matrix tablets, may significantly affect the profile of drug release due to the formation of hydrogel matrix tablets. The aim of this study was to compare the influence of different types of Carbopol? (carbomers in the pharmacopoeia) on the release rate of lithium-carbonate and other pharmaceutical, technological, physical and chemical properties of the prepared formulations of matrix tablets. Methods. Three different formulations of ma

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Pathan, Irfan Mustafa, Vishal S. Madankar, and Anil B. Panchal. "Formulation and Evaluation of Guava Leaf-Based Nanogel for Mouth Ulcer Treatment." Journal of Drug Delivery and Therapeutics 15, no. 4 (2025): 13–19. https://doi.org/10.22270/jddt.v15i4.7069.

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Mouth ulcers, also known as aphthous ulcers, are painful lesions affecting the oral mucosa, causing discomfort and irritation. Conventional treatments, such as antiseptic gels and corticosteroids, provide temporary relief but may have side effects with prolonged use. Guava leaves (Psidium guajava) contain bioactive compounds such as flavonoids, tannins, and polyphenols, which exhibit antimicrobial, anti-inflammatory, and wound-healing properties. This study focuses on the formulation of a simple, Nanogel using Carbopol 934 as a base for the treatment of mouth ulcers. The gel was prepared by in

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Mukherjee, Jayanti, Shivani Khoware, and Sheetal Bhasin. "To Evaluate the Stability of Carbopol 934 based Transdermal Gel of Paracetamol Nanocapsules." International Journal of Current Microbiology and Applied Sciences 9, no. 4 (2020): 3097–104. http://dx.doi.org/10.20546/ijcmas.2020.904.361.

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Begum, M. Yasmin, Ali Alqahtani, Mohammed Ghazwani, et al. "Preparation of Carbopol 934 Based Ketorolac Tromethamine Buccal Mucoadhesive Film: In Vitro, Ex Vivo, and In Vivo Assessments." International Journal of Polymer Science 2021 (October 11, 2021): 1–11. http://dx.doi.org/10.1155/2021/4786488.

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The goal of present investigation was to formulate and evaluate ketorolac tromethamine (KTM) mucoadhesive buccal films. The films were prepared by solvent evaporation method using PVP K30, HPMC K4M, HPMC K15M, carbopol 934, chitosan, and sodium alginate as polymers and propylene glycol as plasticizer. The films were evaluated for thickness, weight variation, folding endurance, surface pH, swelling index, in vitro residence time, in vitro diffusion, release kinetics, ex vivo permeation, in vitro-ex vivo correlation, and in vivo pharmacological activities such as anti-inflammatory and analgesic

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Pakhale, Nilesh V., S. B. Gondkar, and R. B. Saudagar. "Formulation Development and Evalua Tion of Fluoxetine Effervescent Floating Tablet." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 358–66. http://dx.doi.org/10.22270/jddt.v9i4-a.3490.

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The objective of the present study was to formulate and evaluate Effervescent Floating Tablet of Fluoxetine for the treatment of antidepressant agent. Tablets were prepared by direct compression using directly compressible polymers such as HPMC K4M, and Carbopol 934 were evaluated for drug-excipient compatibility, density, buoyancy test, swelling study, drug content and In-Vitro release profile. Sodium bicarbonate and citric acid were used producing effervescent base for buoyancy of tablets. Analysis of drug release from tablet indicates drug release by zero order, first order rate kinetics. N

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Das, Tama, Mahuli Manna, and Anandamoy Rudra. "Formulation and characterization of papaya leaf gel." GSC Biological and Pharmaceutical Sciences 10, no. 3 (2020): 089–94. https://doi.org/10.5281/zenodo.4279713.

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The study was designed for ethanolic extraction of papaya leaf, phytochemical screening of the extract, formulation of papaya leaf gel by using carbopol 934 and characterization of the herbal gel. The fresh papaya leaves were collected and extracted by maceration process using ethanol as a solvent. The extract was analysed by UV spectrophotometer and IR spectroscopy for identification of phytochemical compounds. Then the phytochemical evaluation was performed and the presence of glycoside, tannins, flavonoids and saponins were observed. The herbal gel was prepared by using carbopol 934 polymer

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Dhananjay, Patil* Abdurrahman Helal Ahmed Mohammed Awais Sanaurrahman Rajashri More Karishma Shrivastav Rupesh Deore Vinod Bairagi. "FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF SILDENAFIL CITRATE LIGNOCAINE HCl GEL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 08 (2018): 7921–37. https://doi.org/10.5281/zenodo.1403219.

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<em>The present study was undertaken to formulate, development and in vitro evaluation</em> <em>of Sildenafil Lignocaine gel</em>. <em>Sildenafil citrate is a drug of choice used in the treatment of premature ejaculation disorder</em>. <em>Topical gel has gained more and more importance because the gel based formulations are better percutaneously absorbed than creams and ointment bases</em>. <em>Therefore, topical gel of Sildenafil citrate was prepared using polymer of Carbopol 934 and triethanolamine at different proportions</em>. <em>The study encompasses compatibility studies using FTIR spe

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Misbah, Khanum Dr. C.S.R. Lakshmi. "Development and Evaluation of Nanoparticles Based Topical Gel Containing Antifungal Drug Fluconazole." International Journal Of Pharmaceutical And Bio-Medical Science 01, no. 09 (2021): 181–91. https://doi.org/10.47191/ijpbms/v1-i9-02.

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The objective of this work was to prepare Fluconazole nanoparticles, and then incorporated into the freshly prepared gel for transdermal delivery, reducing the oral side effects of the drug and forenhancing stability. Fluconazole is commonly used antifungal agents for the treatment of local and systemic fungal infections. In this study Fluconazole nanoparticles was prepared by usingEudragit RL 100 by nanoprecipitation method with different drugs to polymer (1:1, 1:2 and 1:3) and stabilizer (Poloxamer 188) ratios (0.5%, 0.75% and 1%) and evaluated for various parameters.Drug-excipients compatib

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Sulaiman, Halah Talal, Saba Abdulhadi Jabir, and Khalid Kadhem Al-kinani. "INVESTIGATING THE EFFECT OF DIFFERENT GRADES AND CONCENTRATIONS OF PH‑SENSITIVE POLYMER ON PREPARATION AND CHARACTERIZATION OF LIDOCAINE HYDROCHLORIDE AS IN SITU GEL BUCCAL SPRAY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 401. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.28492.

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Objective: The present study was aimed to develop a pH-triggered in situ gel for local release of lidocaine hydrochloride (lidocaine HCL) in the buccal cavity to improve the anesthetic effect of this amino amide drug which has very high water solubility. The formulations were introduced to the oral cavity as a spray to improve compliance and for easier administration.Methods: In this work, two grades of carbopol (934 and 940)-based in situ gel spray were designed. The formulations containing lidocaine HCl 5% were prepared by mixing different concentrations of carbopol with xanthan gum. Eight f

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Sonali, Verma1* Sandhya2. "Formulation And Development And In Vitro Evaluation Of Ocimum Sanctum Leave Microemulgel For Antioxidant Activity." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 27–38. https://doi.org/10.5281/zenodo.13871143.

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This study aimed to formulate and evaluate Microemulgel loaded with Ocimum sanctum leaf extract for antioxidant activity. Leaves were extracted using methanol, ethanol, and water, with ethanol providing the highest yield. The phytochemical analysis demonstrated the presence of bioactive compounds like alkaloids, flavonoids, terpenoids, and steroids in the extracts. Three formulations of Microemulgel were developed using different polymers - Carbopol 934, Carbopol 940, and HPMC. The formulated Microemulgel exhibited desirable properties including slightly acidic pH, high viscosity, and good spr

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Pranay, Sawant* Tejas Sutar Sayali Sawant Susmita Holmukhe. "Design and Assessment of Mucoadhesive Insitu Gel Forming Spray for Oral Delivery of Ibuprofen." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3263–76. https://doi.org/10.5281/zenodo.15288007.

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The present study was aimed to develop an insitu gel forming spray for local release of Ibuprofen in the buccal cavity to improve the analgesic effect of NSAID drug which has poor water solubility. The formulations were introduced to the oral cavity as a spray to improve compliance and for easier administration. In this work, two grades of Carbopol (934 and 940)-based in situ gel spray were designed. The formulations containing Ibuprofen spray prepared by mixing different concentrations of Carbopol with xanthan gum. Four formulations were investigated and evaluated for pH, gelation capacity, s

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Ranganathan, Sundhararajan, Rajalakshmi Gopalakrishnan, RESHMA Chittettu Shajimon, et al. "Formulation and Evaluation of Cosmetic Gel Using Maranta Arundinacea L." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 60–65. http://dx.doi.org/10.22270/jddt.v13i5.6068.

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In this study an attempt was made to formulate cosmetic gel using Maranta arundinacea (arrowroot powder) Arrowroot contains flavonoids which is known for its anti-inflammatory properties, antibacterial properties from long time. It has earned a reputation as an elegant, lightweight, all-natural absorbent powder with added skin-nourishing, reduce oiliness, anti-inflammatory properties, anti-irritant properties and for treating wounds from historical times. The rhizome of the plant was processed to obtain arrowroot powder. The cosmetic gel was developed using two polymers carbopol 934 and sodium

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Megha, Patel* Vishal Chudasama Kiran Suthar Bharat Rajpurohit. "Formulation and Evaluation of Polyherbal Gel." International Journal of Pharmaceutical Sciences, no. 7 (July 17, 2024): 1217–25. https://doi.org/10.5281/zenodo.12760617.

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<em>Centella asiatica</em> is beneficial in the treatment of wounds and ulcerous skin abnormalities, <em>Curcuma longa</em> exhibits remarkable anti-inflammatory and antioxidant activity and <em>Terminalia arjuna</em> has antioxidant and astringent property. Rationalizing to this traditional claim, the present study was designed to develop and evaluate polyherbal gel containing alcoholic extract of <em>Centella asiatica, Curcuma longa</em> and<em> Terminalia arjuna.</em> <em> </em>The individual herbs were evaluated for their standard specification according to the Herbal Pharmacopoeia of

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Gowripattapu, Sridevi, Anusha Nallamilli, and Ashokbabu K. S. "FORMULATION AND EVALUATION OF CAPTOPRIL BIOADHESIVE MICROSPHERES." INDIAN DRUGS 58, no. 09 (2021): 70–72. http://dx.doi.org/10.53879/id.58.09.12410.

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In the present work, captopril microspheres using HPMCK100M, HPMCK15M and Carbopol 934 as copolymers were formulated by ionic cross linking technique (ionotropic gelation method) to deliver captopril via oral route. The technique was successfully employed to fabricate captopril microspheres and provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system and thus avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents are costly and hazardous. Micromeritic studies revealed that the mean particle size wa

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Kavitha., K. *. Kavitha. T. Reshma Fathima. K. "PREPARATION AND EVALUATION OF HERBAL GEL FORMULATION OF CISSUS VITIGINEA LEAF." Journal of Pharma Research 7, no. 7 (2018): 179–81. https://doi.org/10.5281/zenodo.1322964.

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<strong><em>ABSTRACT</em></strong> <strong><em>H</em></strong><em>erbal medicines are still being main stay about 75-80% of this world population. Mostly, In developing countries of primary health care due to better cultural acceptability and better compatibility with human body, reduced side effects. Herbal medicines are consist of plant and its parts to treat injuries, diseases or illness which is used to prevent, treat the ailments or to promote the health, healing. A drug or formulation made from plants which are used for any to such purpose. Herbal medicines are oldest form of healthcare

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Nakul, Kathar, Kamble* Abhay, Jadhav Abhijeet, et al. "FORMULATION AND EVALUATION OF MICROEMULSION BASED HYDROGEL FOR TOPICAL DRUG DELIVERY SYSTEM OF KETOCONAZOLE." World Journal of Pharmaceutical Science and Research 3, no. 4 (2024): 134–46. https://doi.org/10.5281/zenodo.13151089.

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The goal of the current study was to create a hydrogel formulation based on microemulsions for the topical application of ketoconazole that has increased microbiological activity while avoiding systemic side effects. A medication with antifungal properties. Oleic acid was chosen after several oils were evaluated for drug solubility. To create microemulsions, various cosurfactants and surfactants were evaluated. Specifically, Propylene Glycol and Twee 80. The hydrogel based on microemulsion was created using Carbopol 934 as a gel matrix to increase the viscosity of the microemulsion for topical

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Shinkar, D. M., M. S. Alai, and R. B. Saudagar. "Formulation and Evaluation of Floating Mucoadhesive Tablet of Clopidogrel." International Journal of Current Pharmaceutical Review and Research 8, no. 4 (2017): 320–27. https://doi.org/10.5281/zenodo.12674964.

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The objective of the present study was to formulate and evaluate Floating Mucoadhesive tablets of Clopidogrel for thetreatment of antithrombotic and antiplatelet agent. Tablets were prepared by direct compression using directly compressiblepolymers such as HPMC K4M, and Carbopol 934 were evaluated for drug-excipient compatibility, density, buoyancy test,mucoadhesion force, swelling study, drug content and In-Vitro release profile. Sodium bicarbonate and citric acid wereused producing effervescent base for buoyancy of tablets. Analysis of drug release from tablet indicates drug release byzero o

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