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Journal articles on the topic 'Carbostyrile derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

A., A. FADDA, M. KHALIL A., and M. EL-HABBAL M. "Synthesis of certain Sulphonamides and Aminopyranoquinoline Derivatives from 4-Hydroxyquinoline with Biological Interest." Journal of Indian Chemical Society Vol. 68, Jul 1991 (1991): 393–95. https://doi.org/10.5281/zenodo.5991965.

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Department of Chemistry, Faculty of Science, Mansoura University. Mansoura, Egypt <em>Manuscript received 2 April 1990, revised 21 November 1990, accepted 17 July 1991</em> Various sulpbonamides derivatives (3a-d) have been synthesised by the pyridine ring opening of 4-bydroxyqulnollne monoxime (la-d), and screened for their anti-bacterial activity. Furthermore. the reactivity of 4-hydroxyquinoline (1) towards different activated nitriles has been studied.

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2

Ye, Lumeng, Pierre Cornelis, Karel Guillemyn, Steven Ballet, Carsten Christophersen, and Ole Hammerich. "Structure Revision of N-Mercapto-4-formylcarbostyril Produced by Pseudomonas fluorescens G308 to 2-(2-Hydroxyphenyl)thiazole-4-carbaldehyde [aeruginaldehyde]." Natural Product Communications 9, no. 6 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900615.

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An antibiotic substance isolated from Pseudomonas fluorescens strain G308 was earlier assigned the structure of N-mercapto-4-formylcarbostyril, but computational predictions of the 1H and 13C NMR magnetic shielding tensors show this structure to be incompatible with the published spectroscopic data. The same is true for six quinoline derivatives related to N-mercapto-4-formylcarbostyril by permutation of the O and S atoms. In contrast, 2-(2-hydroxyphenyl)thiazole-4-carbaldehyde [aeruginaldehyde], isolated from Pseudomonas protegens Pf-5, together with the reduced derivative aeruginol, displays

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3

Milecki, Jan, Stephen P. Baker, Kelly M. Standifer, et al. "Carbostyril derivatives having potent .beta.-adrenergic agonist properties." Journal of Medicinal Chemistry 30, no. 9 (1987): 1563–66. http://dx.doi.org/10.1021/jm00392a006.

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4

Ge, Pinghua, and Paul R. Selvin. "Carbostyril Derivatives as Antenna Molecules for Luminescent Lanthanide Chelates." Bioconjugate Chemistry 15, no. 5 (2004): 1088–94. http://dx.doi.org/10.1021/bc049915j.

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5

Thumar, Nilesh J., and Manish P. Patel. "Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole." Saudi Pharmaceutical Journal 19, no. 2 (2011): 75–83. http://dx.doi.org/10.1016/j.jsps.2011.01.005.

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6

Kaiser, Carl, Penelope A. Dandridge, Eleanor Garvey, Kathryn E. Flaim, Robert L. Zeid, and J. Paul Hieble. "Dopamine receptor agonist activity of some 5-(2-aminoethyl)carbostyril derivatives." Journal of Medicinal Chemistry 28, no. 12 (1985): 1803–10. http://dx.doi.org/10.1021/jm00150a010.

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7

Phaniband, Mohammedshafi A., Prakash Gouda Avaji, and Shreedhar D. Dhumwad. "Synthesis, spectral characterization and biological evaluation of some Lanthanide(III) complexes of Schiff bases of carbostyril derivatives." Main Group Chemistry 7, no. 4 (2008): 271–83. http://dx.doi.org/10.1080/10241220802688442.

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8

Shanazarov, A. K., V. V. Chistyakov, and V. G. Granik. "Unusual reaction of N,N-dimethylacetamide diethyl acetal with 2-aminomethylene-5,5-dimethylcyclohexane-1,3-dione. Synthesis of coumarin and carbostyril derivatives." Chemistry of Heterocyclic Compounds 22, no. 1 (1986): 106–7. http://dx.doi.org/10.1007/bf00515437.

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9

Grannik, V. G., A. K. Shanazarov, N. P. Solov'eva, V. V. Chistyakov, I. V. Persianova, and Yu N. Sheinker. "Acetals of lactams and acid amides. 48. Reaction of enamino diketones with amide crystals. Synthesis of derivatives of coumarin and carbostyril." Chemistry of Heterocyclic Compounds 23, no. 11 (1987): 1171–77. http://dx.doi.org/10.1007/bf00479362.

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10

Tourwé, D., and G. van Binst. "Benzo- and indoloquinolizine derivatives - VIII: A Two-step carbostyril preparation in the synthesis of dibenzo[a, f]-and benz[f]indolo[2,3-a]quinolizines." Bulletin des Sociétés Chimiques Belges 85, no. 1-2 (2010): 11–25. http://dx.doi.org/10.1002/bscb.19760850102.

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11

Usachev, Sergey A., Boris I. Usachev, and Vyacheslav Ya Sosnovskikh. "Synthesis of 3-(trifluoromethyl)indeno[2,1-c]pyran-1,9-diones from 4-aryl-3-carbethoxy-6-(trifluoromethyl)-2-pyrones and their reaction with sodium azide leading to new carbostyril derivatives." Tetrahedron 70, no. 1 (2014): 60–66. http://dx.doi.org/10.1016/j.tet.2013.11.033.

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12

Usachev, Sergey A., Boris I. Usachev, and Vyacheslav Ya Sosnovskikh. "ChemInform Abstract: Synthesis of 3-(Trifluoromethyl)indeno[2,1-c]pyran-1,9-diones from 4-Aryl-3-carbethoxy-6-(trifluoromethyl)-2-pyrones and Their Reaction with Sodium Azide Leading to New Carbostyril Derivatives." ChemInform 45, no. 28 (2014): no. http://dx.doi.org/10.1002/chin.201428147.

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13

"4460593 Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives." Neuroscience 14, no. 2 (1985): 749. http://dx.doi.org/10.1016/0306-4522(85)90326-4.

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14

"4734416 Pharmaceutically useful carbostyril derivatives." General Pharmacology: The Vascular System 20, no. 1 (1989): ii. http://dx.doi.org/10.1016/0306-3623(89)90083-9.

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15

Syed, Hafeez Ahmed1 Haney Ahmed2 Syed Habeeb Ali2 Sabiha Fatima2 Shafia Hyder2 Amjad Pasha2. ""SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF SOME NOVEL PYRAZOLIDINEDIONE SUBSTITUTED DERIVATIVES OF 2-QUINOLONES"." November 30, 2017. https://doi.org/10.5281/zenodo.2529245.

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Although a number of drugs are available in the market, thrust for discovery of new antimicrobial drugs with better pharmacokinetic profile, and lesser toxicity has become necessary in the field of medicinal chemistry due to fast development of microbial resistance towards the existing molecules. The 2(1H) quinolinone, often referred to as carbostyril moiety, is an important structural unit present in many biologically active molecules. Quinolone antibiotics have gained wide acceptance for the treatment of various bacterial infections. Their mode of action is believed to involve inhibition of

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16

"Carbostyril derivatives and pharmaceutical preparations containing same." General Pharmacology: The Vascular System 20, no. 6 (1989): IX—X. http://dx.doi.org/10.1016/0306-3623(89)90393-5.

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17

"4455422 Carbostyril derivatives and pharmaceutical composition containing the same." General Pharmacology: The Vascular System 16, no. 1 (1985): xix—xx. http://dx.doi.org/10.1016/0306-3623(85)90339-8.

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18

MILECKI, J., S. P. BAKER, K. M. STANDIFER та ін. "ChemInform Abstract: Carbostyril Derivatives Having Potent β-Adrenergic Agonist Properties." ChemInform 19, № 6 (1988). http://dx.doi.org/10.1002/chin.198806169.

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19

Erşatır, Mehmet, Metin Yıldırım, and Elife Sultan Giray. "Carbostyril derivatives: Synthesis of novel carbostyril-3′-carbonitrilselenophene hybrid compounds and investigation of their antiproliferative properties on prostate and breast cancer." Synthetic Communications, October 5, 2020, 1–12. http://dx.doi.org/10.1080/00397911.2020.1825744.

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20

Syed, Hafeez Ahmed1 Haney Ahmed2 Syed Habeeb Ali2 Sabiha Fatima2 Shafia Hyder2 Amjad Pasha2. ""SYNTHESIS AND ANTI-BACTERIAL ACTIVITY OF SOME NOVEL PYRAZOLIDINEDIONE SUBSTITUTED DERIVATIVES OF 2-QUINOLONES"." October 31, 2017. https://doi.org/10.5281/zenodo.2527457.

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Although a number of drugs are available in the market, thrust for discovery of new antimicrobial drugs with better pharmacokinetic profile, and lesser toxicity has become necessary in the field of medicinal chemistry due to fast development of microbial resistance towards the existing molecules. The 2(1H) quinolinone, often referred to as carbostyril moiety, is an important structural unit present in many biologically active molecules. Quinolone antibiotics have gained wide acceptance for the treatment of various bacterial infections. Their mode of action is believed to involve inhibition of

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21

KAISER, C., P. A. DANDRIDGE, E. GARVEY, K. E. FLAIM, R. L. ZEID, and J. P. HIEBLE. "ChemInform Abstract: Dopamine Receptor Agonist Activity of Some 5-(2-Aminoethyl)carbostyril Derivatives." Chemischer Informationsdienst 17, no. 13 (1986). http://dx.doi.org/10.1002/chin.198613204.

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22

"5008274 Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes." General Pharmacology: The Vascular System 22, no. 6 (1991): x. http://dx.doi.org/10.1016/0306-3623(91)90651-l.

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23

Hariguchi, Norimitsu, Xiuhao Chen, Yohei Hayashi, et al. "OPC-167832, a Novel Carbostyril Derivative with Potent Antituberculosis Activity as a DprE1 Inhibitor." Antimicrobial Agents and Chemotherapy 64, no. 6 (2020). http://dx.doi.org/10.1128/aac.02020-19.

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ABSTRACT There is an urgent need for new, potent antituberculosis (anti-TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3,4-dihydrocarbostyril derivatives and identified OPC-167832 as having potent antituberculosis activity. The MICs of the compound for Mycobacterium tuberculosis ranged from 0.00024 to 0.002 μg/ml. It had bactericidal activity against both growing and intracellular bacilli, and the frequency of spontaneous resistance for M. tuberculosis H37Rv was less

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24

AMLAIKY, N., G. LECLERC, N. DECKER та J. SCHWARTZ. "ChemInform Abstract: ETHER DERIVATIVES OF OXIMES WITH A CARBOSTYRIL RING. 4. SYNTHESES AND β-BLOCKING ACTIVITIES". Chemischer Informationsdienst 16, № 2 (1985). http://dx.doi.org/10.1002/chin.198502236.

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25

SHANAZAROV, A. K., V. V. CHISTYAKOV, and V. G. GRANIK. "ChemInform Abstract: Unusual Reaction of N,N-Dimethylacetamide Diethylacetal with 2-Aminomethylene- 5,5-dimethylcyclohexanedione-1,3. Synthesis of Coumarine and Carbostyril Derivatives." Chemischer Informationsdienst 17, no. 22 (1986). http://dx.doi.org/10.1002/chin.198622184.

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26

Tashima, Toshihiko, Yoshinori Suzuma, Yuto Akai, et al. "Rh-catalyzed hydrogenation of the carbon-carbon double bond in carbostyril derivatives using [Rh(cod)2]BF4 and Et3SiH under mild conditions." Tetrahedron Letters, September 2023, 154739. http://dx.doi.org/10.1016/j.tetlet.2023.154739.

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27

GRANIK, V. G., A. K. SHANAZAROV, N. P. SOLOV'EVA, V. V. CHISTYAKOV, I. V. PERSIANOVA, and YU N. SHEINKER. "ChemInform Abstract: Acetals of Lactams and Acid Amides. Part 48. Reaction of Enamino Diketones with Amide Acetals. Synthesis of Coumarin and Carbostyril Derivatives." ChemInform 19, no. 23 (1988). http://dx.doi.org/10.1002/chin.198823156.

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