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Dissertations / Theses on the topic 'Carboxylase. Vitamine K'

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1

Soute, Bernardus Aloysius Maria. "Vitamin K-dependent carboxylase: growth to maturity." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=6218.

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2

Boer-van, den Berg Maria Anna Gerardina de. "Hepatic and non-hepatic vitamin K-dependent reactions." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1987. http://arno.unimaas.nl/show.cgi?fid=5356.

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3

Ulrich, Magdalena Maria Wilhelmina. "Enzyme/substrate interactions of the vitamin K-dependent carboxylase." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1991. http://arno.unimaas.nl/show.cgi?fid=6207.

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4

Darghouth, Dhouba Dalenda. "Etude d'un multi-deficit congénital en facteur de coagulation vitamine K-dépendant dans une famille tunisienne." Paris 7, 2006. http://www.theses.fr/2006PA077089.

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La gamma-glutamyl carboxylase (gammaGC) et l'époxyde réductase (VKOR) sont des enzymes membranaires du réticulum endoplasmique, qui assurent la gamma-glutamyl carboxylation des facteurs vitamine K-dépendants (FVKD) : II, VII, IX, X, protéines C, S, Z. Une patiente tunisienne présentait un syndrome hémorragique avec multi-déficit en FVKD. L'enquête familiale a montré une transmission récessive, avec les parents et une sœur cliniquement indemnes, et un frère atteint. Nous avons amplifié par PCR et séquence les gènes de gammaGC et VKOR. Aucune mutation n'a été trouvée sur VKOR. Par contre la prop
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5

LARUE, VALERY. "Etude conformationnelle par rmn et modelisation moleculaire d'analogues de l'acide glutamique comme sonde de la carboxylase vitamine k dependante." Paris 6, 1996. http://www.theses.fr/1996PA066227.

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Le mecanisme de la coagulation sanguine est un mecanisme fort complexe, de maturation proteique, qui fait intervenir une cascade de reactions enzymatiques et notamment des carboxylations vitamine k dependante de residus glu en gla. La reaction de carboxylation se fait en presence de la carboxylase (une enzyme transmembranaire), de la vitamine k, de co#2 et de dioxygene. En l'absence, de preparation purifiee de carboxylase, une approche passant par l'elaboration de substrats ou d'inhibiteurs peut permettre de mieux definir les caracteristiques du site actif de la carboxylase. Dans ce contexte,
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6

MAILLET, MAGALI. "Carboxylase dependant de la vitamine k : etude du mecanisme d'action du cofacteur et exploration du site actif par photomarquage." Paris 6, 1995. http://www.theses.fr/1995PA066662.

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Nous avons etudie deux aspects de la carboxylation catalysee par la vitamine k. Le role du cofacteur a ete aborde par l'etude de l'incorporation et la localisation d'oxygene (#1#8o#2) au niveau de l'epoxyde de la vitamine k produit, a l'aide d'echantillons enrichis specifiquement. Apres optimisation des conditions experimentales (incorporation #1#8o#2 et extraction des produits), nous avons mis au point les conditions de sm/sm qui doivent permettre de mener l'analyse a son terme. En parllele, nous avons entame l'etude du site actif par marquage irreversible. La premiere tentative, basee sur la
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7

Sung, P. M. W. "Studies on the vitamin K dependent carboxylase." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354867.

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8

Wood, Gary Michael. "Studies on vitamin K-dependent carboxylase." 1986. http://catalog.hathitrust.org/api/volumes/oclc/15540707.html.

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9

Grossman, Carol Paula. "Inhibitors of the vitamin K-dependent carboxylase." 1991. http://catalog.hathitrust.org/api/volumes/oclc/24259287.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1991.<br>Vita. Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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10

Harbeck, Mark Christian. "Studies of the vitamin k-dependent carboxylase." 1992. http://catalog.hathitrust.org/api/volumes/oclc/28952870.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1992.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 139-157).
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11

Anderson, Margaret Elizabeth. "Multi-site specificity of the vitamin K-dependent carboxylase." 1994. http://catalog.hathitrust.org/api/volumes/oclc/31626995.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1994.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 222-243).
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12

Hinck, Cynthia Sanders. "Studies of the microsomal vitamin K-dependent (gamma)-glutamyl carboxylase." 1994. http://catalog.hathitrust.org/api/volumes/oclc/31676749.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1994.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 172-192).
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13

Liska, Deann Joy. "Studies on substrate specificity of glutamate carboxylation by the vitamin K-dependent carboxylase." 1987. http://catalog.hathitrust.org/api/volumes/oclc/17926508.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1987.<br>Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 233-262).
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14

Knobloch, James Edward. "Activation of vitamin K-dependent carboxylase by the propeptide from clotting factor X." 1987. http://catalog.hathitrust.org/api/volumes/oclc/17376038.html.

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Thesis (M.S.)--University of Wisconsin--Madison, 1987.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 93-97).
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15

Lin, Tzu-Ching, та 林子欽. "Inhibition and Mechanistic Studies of 4-Hydroxyphenyl-pyruvate Dioxygenase and Synthesis of the Potential Vitamin K-dependent γ-Glutamate Carboxylase Inhibitors". Thesis, 2000. http://ndltd.ncl.edu.tw/handle/00309455780605315595.

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碩士<br>東海大學<br>化學系<br>88<br>Abstract I. Inhibition and Mechanistic Studies of 4-Hydroxyphenylpyruvate Dioxygenase 4-Hydroxyphenylpyruvate dioxygenase (4-HPPD) catalyzes the reaction of 4-hydroxyphenylpyruvate with molecular oxygen to homogentisate and carbon dioxide. In our continuous efforts to elucidate this intriguing enzyme catalyzed reaction, we have designed and chemically synthesized compound 21 as the substrate analogue. After incubation with enzyme 4-HPPD, compound 21 was found to be neither a substrate nor an inhibitor for 4-HPPD. Compound 23 and 24 were a
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16

Nguyen, Sa Lan [Verfasser]. "Die genetische Variabilität des γ-Glutamyl-Carboxylase-Gens [Gamma-Glutamyl-Carboxylase-Gens] (GGCX) bei Patienten mit angeborener Verminderung der Vitamin-K-abhängigen Gerinnungsfaktoren und in der Allgemeinbevölkerung / vorgelegt von Sa Lan Nguyen". 2009. http://d-nb.info/1007731168/34.

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