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Journal articles on the topic 'Carboxylic acid derivatives'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Kubicki, Maciej, Teresa Borowiak, and Wiesław Z. Antkowiak. "Hydrogen Bonds in "Carboxyoximes": the Case of Bomane Derivatives." Zeitschrift für Naturforschung B 55, no. 8 (2000): 677–84. http://dx.doi.org/10.1515/znb-2000-0802.

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Abstract The tendency of forming mixed carboxyl-to-oxime hydrogen bonds was tested on the series of bornane derivatives: one with the acid function only (bornane-2-endo-carboxylic acid), one with the oxime function (2,2′-diethylthiobomane-3-oxime), and one with both oxime and carboxylic functions (bornane-2-oxime-3-endo-carboxylic acid). The crystal structures of these compounds were determined by means of X-ray diffraction. In bornane-2-endo-carboxylic acid and 2,2′-diethylthiobornane-3-oxime 'homogenic' hydrogen bonds were found, and these hydrogen bonds close eight-and six-membered rings, r

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2

Mardjan, Muhammad Idham Darussalam, Retno Ambarwati, Sabirin Matsjeh, Tutik Dwi Wahyuningsih, and Winarto Haryadi. "SYNTHESIS OF FLAVANONE-6-CARBOXYLIC ACID DERIVATIVES FROM SALICYLIC ACID DERIVATIVE." Indonesian Journal of Chemistry 12, no. 1 (2012): 70–76. http://dx.doi.org/10.22146/ijc.21374.

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Synthesis of flavanone-6-carboxylic acid derivatives had been conducted via the route of chalcone. The synthesis was carried out from salicylic acid derivative, i.e. 4-hydroxybenzoic acid, via esterification, Fries rearrangement, Claisen-Schmidt condensation and 1,4-nucleophilic addition reactions. Structure elucidation of products was performed using FT-IR, 1H-NMR, GC-MS and UV-Vis spectrometers. Reaction of 4-hydroxybenzoic acid with methanol catalyzed with sulfuric acid produced methyl 4-hydroxybenzoate in 87% yield. The acid-catalyzed-acetylation of the product using acetic anhydride gave

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3

Spassova, Maria K., Antonín Holý, and Milena Masojídková. "Ribonucleosides of 3-amino- and 3,5-diaminopyrazole-4-carboxylic acid and their open-chain analogues: Synthesis and reactions." Collection of Czechoslovak Chemical Communications 51, no. 7 (1986): 1512–31. http://dx.doi.org/10.1135/cccc19861512.

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Bis(trimethylsilyl) derivative of ethyl 3-aminopyrazole-4-carboxylate (VI) and tris(trimethylsilyl) derivative of ethyl 3,5-diaminopyrazole-4-carboxylate (VII) on reaction with 2,3,5-tri-O-benzoyl-D-ribofuranolyl chloride and subsequent debenzoylation afforded the respective β-D-ribofuranosyl derivatives VIIIa and Xa. Their alkaline hydrolysis led to 1-(β-D-ribofuranosyl)-3-aminopyrazole-4-carboxylic acid (VIIIc) and 1-(β-D-ribofuranosyl)-3,5-diaminopyrazole-4-carboxylic acid (Xb). The esters VIIIa and Xa were not ammonolyzed under normal conditions. Contrary to nucleosidation of the silyl der

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4

Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were

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5

Mortier, Jacques, Michel Vaultier, Barbara Plunian та Sourisak Sinbandhit. "Réactions daddition conjuguée dorganolithiens aux acides carboxyliquesα, β-insaturés". Canadian Journal of Chemistry 77, № 1 (1999): 98–112. http://dx.doi.org/10.1139/v98-222.

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In THF at -78°C, organolithium derivatives and unprotected α, β-unsaturated carboxylic acids give a conjugated addition reaction. Reactions of 1- and 2-naphthoic acids with various organolithium derivatives and electrophiles are reported. Two X-ray studies show that the reaction occurs with a good diastereoselectivity: the dilithiated enolate formed as an intermediate adds the electrophile exclusively via the face opposite to that of the organolithium. A study of the 1 H NMR spectra of the products obtained shows that these compounds adopt a preferred conformation in solution. The protonolysis

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6

Kraľovičová, Eva, Alžbeta Krutošíková, and Jaroslav Kováč. "Preparation and reactions of thieno[3,2-b]furan derivatives." Collection of Czechoslovak Chemical Communications 51, no. 8 (1986): 1685–91. http://dx.doi.org/10.1135/cccc19861685.

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Reactions of 3-(5-aryl-2-furyl)propenoic, 3-(2-benzo[b]furyl)propenoic and 3-(5-ethoxycarbonyl-4H-furo[3,2-b]-2-pyrrolyl)propenoic acids with thionyl chloride in the presence of triethylbenzylammonium chloride were investigated. The obtained 2-arylthieno[3,2-b]-furan-5-carboxylic acid chlorides Ia - Ic and 3-chlorothieno[3,2-b]benzo[b]furan-2-carboxylic acid chloride afforded in substitution nucleophilic reactions the corresponding esters V and carboxylic acids VI which were decarboxylated to VII. 3-Chlorothieno[3,2-b]benzo[b]furan-2-carboxylic acid chloride (Id), 6-ethoxycarbonyl-3-chlorothie

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7

Šťastná, Eva, Hana Chodounská, Vladimír Pouzar, Jiřina Borovská, and Ladislav Vyklický. "Synthesis of pregnane 3-carboxylic acids via Pd-catalyzed alkoxycarbonylation and their effect on NMDA receptor activity." Collection of Czechoslovak Chemical Communications 76, no. 9 (2011): 1141–61. http://dx.doi.org/10.1135/cccc2011031.

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We have prepared 20-oxo-5α- and 20-oxo-5β-pregnane-3-carboxylic acids by palladium catalyzed alkoxycarbonylation using triflate and nonaflate as the leaving groups in this substitution reaction. The activity of the synthesized compounds was studied in cultured rat hippocampal neurons under voltage-clamp conditions. The 5β-carboxylic acid derivatives were found to diminish NMDA-induced responses, whereas the 5α-derivative potentiated the response.

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8

Bakare, Safyah B. "Synthesis and anticancer evaluation of some coumarin and azacoumarin derivatives." Polish Journal of Chemical Technology 23, no. 2 (2021): 27–34. http://dx.doi.org/10.2478/pjct-2021-0013.

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Abstract Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones and lactams, respectively, which are indispensable heterocyclic units to both chemists and biochemists. 1-Aza coumarin derivatives, which ultimately metabolize as the corresponding 8-hydroxy coumarins in the biological system are therefore found to be very good anti-inflammatory, anti-cancer, and analgesic agents. A series of hybrid substituted coumarin and azacoumarin-3-carboxylic acid derivatives (8-methoxycoumarin-3-carboxylic acid (4a), 8-methoxyazacoumarin-3-carboxylic acid (4b), 5-bromo-8-methoxycoumarin-3

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9

USIFOH, C. O. "3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone." Scientia Pharmaceutica 68, no. 3 (2000): 275–79. http://dx.doi.org/10.3797/scipharm.aut-00-25.

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Alkylation of quinazolinone-2-carboxylic acids with propargyl bromide in dimethylformamide in the presence of potassium carbonate afforded 3-prop-2-ynyl quinazolinone-2-substituted carboxylic acid derivatives. Further reaction of 4b-c produced 5b-c, which indicates that N-alkylation occurs before esterification with a propynyl moiety.

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10

Gaber, Ahmed, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Ibrahim M. El-Deen, and Moamen S. Refat. "Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs." Crystals 11, no. 5 (2021): 565. http://dx.doi.org/10.3390/cryst11050565.

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This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst to give ethyl coumarin-3-carboxylate, followed by the ammonolysis of ester (ethyl coumarin-3-carboxylate) with ammonia in the presence of anhydrous potassium carbonate. Treatment of 2-oxo-1H-quinoline-3-carboxylic acid with acetic anhydride, cinnamaldehyde, cinnamic acid and methyl 5-phenyl-2-cyano-2,4-pentadienoat

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11

Erdem, Ahmet, Hasan Genc, Nejdet Sen, Rafet Kilincarslan, and Emin Erdem. "The Synthesis and Reactions of Novel Pyrazole Derivatives by 4-phenylcarbonyl-5-phenyl-2,3-dihydro-2,3-furandione Reacted with Some Hydrazones." Revista de Chimie 68, no. 1 (2017): 143–46. http://dx.doi.org/10.37358/rc.17.1.5407.

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We report some novel pyrazole derivatives taking 4-phenylcarbonyl-5-phenyl-2,3-dihydro-2,3-furandione, 1. For this, 4-phenylcarbonyl-5-phenyl-2,3-dihydro-2,3-furandione, 1 was reacted with benzaldehyde(2- or 4-fluorophenyl)hydrazone to give 4-benzoyl-1-(2- or 4-fluorophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid 2a,b. Pyrazol derivative containing 2-fluorophenyl group 2a was converted into carboxylic chloride derivative 3a by thionyl chloride and then the compound 4a was obtained from reaction ammonia with compound 3a. In the next step, 4-benzoyl-1-(2-fluorophenyl)-5-phenyl-1H-pyrazole-3-carb

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12

Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omar, Mohamed H. Abo-Ghalia, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Carboxamides with an Incorporated Peptide Linkage Using Nalidixic Acid and Amino Acids as Starting Materials." Zeitschrift für Naturforschung B 69, no. 3 (2014): 351–61. http://dx.doi.org/10.5560/znb.2014-3282.

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4bA series of chiral linear carboxamide derivatives (2- 15) with an incorporated peptide linkage have been prepared via the coupling of 1-ethyl-1,4-dihydro-7-methyl-4-oxo-quinoline-3-carboxylic acid (nalidixic acid, 1) with appropriate amino acid methyl esters. Coupling of 1 with amino acid methyl esters gave the corresponding peptide methyl esters 2, which were hydrolyzed with methanolic sodium hydroxide to the corresponding acids 3. Hydrazinolysis of esters 2with hydrazine hydrate afforded the corresponding acid hydrazide derivatives 4. The latter compounds were coupled with appropriate alde

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13

Eisele, Roland, Keiichi Aritomo, and Wolfgang Pfleiderer. "Pteridines CI Synthesis and Properties of Lumazine-6- and -7-carboxylic Acids." Pteridines 4, no. 4 (1993): 178–86. http://dx.doi.org/10.1515/pteridines.1993.4.4.178.

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Summary Lumazine-6-(8) and 7-carboxylic acid (23) and their N-methyl derivatives (12, 13, 21, 26, 28, 29) have been synthesized and characterized by the determination of their pK values and the UV spectra of the neutral, mono and dianion species. It was noticed that the acidities of the two N-H protons of the pyrimidine moiety are almost the same indicating that the dianions of 8 and 23, respectively, are I: 1 mixtures of the corresponding N-l and N-3 deprotonated forms. The lumazine-7-carboxylic acids (23, 26, 28, 29, 31, 33) are in comparison to their 6-carboxyJic acid counterparts (8, 12, 1

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14

Kowalewska, M., H. Kwiecień, M. Śmist, and A. Wrześniewska. "Synthesis of New Benzofuran-2-Carboxylic Acid Derivatives." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/183717.

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Novel ethyl ester and methylamide of 5-[bis(2-chloroethyl)amino]-7-methoxybenzofuran-2-carboxylic acid as well as (2-hydroxy-1,1-dimethylethyl)amides of 5-bromo- and 5,7-dichlorobenzofuran-2-carboxylic acid were synthesized and characterized.

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15

Rádl, Stanislav, and Lenka Kovářová. "Some reactions of N-propadienyl-4-quinolones." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2413–19. http://dx.doi.org/10.1135/cccc19912413.

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N-Alkylation of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Vg) with 3-bromopropyne followed by acidic hydrolysis provided N-propyl derivative Ic which in alkaline media yielded N-propadienyl derivative IId. Propadienyl derivatives IIa and IIb treated with primary or secondary amines provided intermediates IIIa-IIIc which were hydrolyzed to N-acetonyl derivatives IVa and IVb, respectively. N-Benzylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (Va) followed by hydrolysis yielded 1-benzyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic ac

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16

Maclaren, JA. "β-Carboline-3-carboxylic Acid (9H-Pyrido[3,4-b]indole-3-carboxylic Acid) and Related Compounds". Australian Journal of Chemistry 42, № 6 (1989): 813. http://dx.doi.org/10.1071/ch9890813.

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The synthesis of β-carboline-3-carboxylic acid and its esters (4) by oxidation of the corresponding 1,2,3,4-tetrahydro derivatives (2) or of the 3,4-dihydro derivatives (3) has been studied. A novel synthesis of the esters (3) [and hence of (4)] has been achieved in high yield by cyclization and elimination from the enamine (5). The relative inhibition of binding of a benzodiazepine to rat brain membranes by the esters (2)-(4) has been determined.

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17

Huang, Tianyin, Yang Yu, Hui Wang, et al. "Silver-Promoted Regioselective Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids." Synthesis 52, no. 02 (2019): 239–45. http://dx.doi.org/10.1055/s-0039-1690220.

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A novel oxidative decarboxylative C–H alkylation of phenanthridines with carboxylic acids was developed for the efficient synthesis of multi-substituted phenanthridine derivatives. The given method features easy availability of starting materials, high regioselectivity, and mild conditions. Furthermore, a one-pot synthesis of multi-substituted phenanthridine derivatives was realized by the reaction of biphenyl isocyanides and carboxylic acid.

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18

Abualhasan, Murad N., and David G. Watson. "Tagging Fatty Acids Via Choline Coupling for the Detection of Carboxylic Acid Metabolites in Biological Samples." Current Analytical Chemistry 15, no. 6 (2019): 642–47. http://dx.doi.org/10.2174/1573411014666180516093353.

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Background: Fatty acids and other metabolites containing a carboxyl group are of high interest in biomedicine because of their major role in many metabolic pathways and, particularly in the case of oxidised fatty acids, their high biological activity. Tagging carboxylic acid compounds with a permanent positive charge such as a quaternary ammonium compound could increase the LC-MS detection sensitivity and selectivity. This paper describes a new and novel strategy for analysing carboxylcontaining compounds in biological samples by ESI-MS through coupling to choline. Methods: Coupling of carboxy

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19

Sietmann, Rabea, Elke Hammer, Michael Specht, Carl E. Cerniglia, and Frieder Schauer. "Novel Ring Cleavage Products in the Biotransformation of Biphenyl by the Yeast Trichosporon mucoides." Applied and Environmental Microbiology 67, no. 9 (2001): 4158–65. http://dx.doi.org/10.1128/aem.67.9.4158-4165.2001.

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ABSTRACT The yeast Trichosporon mucoides, grown on either glucose or phenol, was able to transform biphenyl into a variety of mono-, di-, and trihydroxylated derivatives hydroxylated on one or both aromatic rings. While some of these products accumulated in the supernatant as dead end products, the ortho-substituted dihydroxylated biphenyls were substrates for further oxidation and ring fission. These ring fission products were identified by high-performance liquid chromatography, gas chromatography-mass spectrometry, and nuclear magnetic resonance analyses as phenyl derivatives of hydroxymuco

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20

Machácek, Vladimír, Petr Jansa, and Valerio Bertolasi. "Derivatives of 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid." HETEROCYCLES 68, no. 1 (2006): 59. http://dx.doi.org/10.3987/com-05-10571.

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21

Matela, Garima, and Robina Aman. "Organotin(IV) complexes of carboxylic acid derivatives." Open Chemistry 10, no. 1 (2012): 1–15. http://dx.doi.org/10.2478/s11532-011-0107-6.

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AbstractA comprehensive review, >100 references, on organotin(IV) complexes of the carboxylic acid derivatives are presented with special reference to their methods of synthesis, spectroscopic and structural studies and their biological activities. The structures of these complexes are discussed on the basis of IR, multinuclear (1H-, 13C- and 119Sn-) NMR.

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22

L�vai, Albert. "Synthesis of carboxylic acid derivatives of dihydrochalcones." Monatshefte f�r Chemie Chemical Monthly 122, no. 1-2 (1991): 127–29. http://dx.doi.org/10.1007/bf00815173.

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23

Bondarenko, N. A., M. V. Raitarskaya, M. V. Rudomino, and E. N. Tsvetkova. "Synthesis of Phosphorus-Containing Carboxylic Acid Derivatives." Phosphorus, Sulfur, and Silicon and the Related Elements 51, no. 1-4 (1990): 381. http://dx.doi.org/10.1080/10426509008040908.

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24

Luk'yanov, O. A., and N. I. Shlykova. "Derivatives of 1-hydroxytetrazole-5-carboxylic acid." Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 36, no. 11 (1987): 2358–61. http://dx.doi.org/10.1007/bf00957315.

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25

Shengelia, M. S., V. G. Avramenko, L. N. Kuleshova, N. N. Suvorov, V. A. Silin, and E. N. Padeiskaya. "Derivatives of 5-nitroindole-2-carboxylic acid." Pharmaceutical Chemistry Journal 19, no. 9 (1985): 617–20. http://dx.doi.org/10.1007/bf00766843.

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26

Luo, Sanzhong, Longji Li, Qi Yang, and Zongbin Jia. "Organocatalytic Electrochemical C–H Lactonization of Aromatic Carboxylic Acids." Synthesis 50, no. 15 (2018): 2924–29. http://dx.doi.org/10.1055/s-0036-1591558.

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An electrochemical strategy has been developed for radical arene carbon–oxygen bond formation. This reaction utilizes DDQ as a redox mediator, with inexpensive glassy carbon electrodes to facilitate an intramolecular lactonization of biphenyl-2-carboxylic acid derivatives via aromatic carboxyl radical substitution to give 6H-benzo[c]chromen-6-ones.

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27

Akishina, E. A., E. A. Dikusar, S. K. Petkevich, and V. I. Potkin. "Synthesis of isoxazole and isothiazole derivatives of curcumin." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 56, no. 2 (2020): 187–91. http://dx.doi.org/10.29235/1561-8331-2020-56-2-187-191.

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Curcumin is a chemical compound with antioxidant properties as well as strong anti-inflammatory, antiviral, analgesic, antimicrobial and antitumor effect, contained in the tuberous rhizomes of the turmeric plant (Curcuma longa). Curcumin derivatives are being intensively studied as potential drugs – antitumor drugs for the treatment of certain forms of cancer. The presence of reactive functional groups makes curcumin a convenient starting compound for the further chemical modification. The esters of curcumin and 5-phenylisoxazole-3-carboxylic acid, 5-(p-tolyl)isoxazole-3-carboxylic acid, 4,5-

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28

Genç, Hasan, Volkan Taşdemir, İsrafil Tozlu, and Erdal Ögün. "Synthesis of Novel Tetra-Substituted Pyrazole Derivatives from 2,3- Furandione." Letters in Organic Chemistry 16, no. 11 (2019): 891–97. http://dx.doi.org/10.2174/1570178616666190314150302.

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Synthesis of pyrazole-3-carboxylic acid was progressed via two different protocols, one of which is solid state. Pyrazole-3-carboxylic acid was converted into different derivatives such as ester, urea, amide and nitrile. The amide compound was converted to nitrile using SOCl2 and DMF. Solid state heating of carboxylic acid gave decarboxylated product. Cyclization of tetra-substituted pyrazole with hydrazines resulted in pyrazolopyridazinones. The antimicrobial activities of the synthesized pyrazole derivatives against Bacillus cereus, Escherichia coli, Micrococcus luteus, Staphylococcus aureus

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29

Padrtová, Tereza, Pavlína Marvanová, Renáta Kubínová, et al. "Indol-2-Carboxylic Acid Esters Containing N-Phenylpiperazine Moiety - Preparation and Cholinesterase-inhibiting Activity." Current Organic Synthesis 17, no. 7 (2020): 576–87. http://dx.doi.org/10.2174/1570179417666200619132218.

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Background: The indole derivatives and the N-phenylpiperazine fragment represent interesting molecular moieties suitable for the research of new potentially biologically active compounds. This study was undertaken to identify if indol-2-carboxylic acid esters containing N-phenylpiperazine moiety possess acetylcholinesterase and butyrylcholinesterase inhibitory activity. Materials and Methods: The study dealt with the synthesis of a novel series of analogs of 1H-indole-2- carboxylic acid and 3-methyl-1H-indole-2-carboxylic acid. The structure of the derivatives was represented by the indolylcar

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30

Branham, Keith E., Jimmy W. Mays, Gary M. Gray, Robert D. Sanner, George E. Overturf, and Robert Cook. "Reactions of Titanocene Derivatives with Molecular Carboxylic Acids and Copolymers Bearing Carboxylic Acid Groups." Applied Organometallic Chemistry 11, no. 3 (1997): 213–21. http://dx.doi.org/10.1002/(sici)1099-0739(199703)11:3<213::aid-aoc555>3.0.co;2-o.

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31

Patil, Pravin, and Frederick Luzzio. "Unnatural Amino Acid Derivatives through Click Chemistry: Synthesis of Triazolylalanine Analogues." Synlett 28, no. 14 (2017): 1729–32. http://dx.doi.org/10.1055/s-0036-1588510.

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A novel tert-butyl 2-(1-oxoisoindolin-2-yl)acetate derivative is selectively alkylated with propargyl bromide in the presence of lithium hexamethyldisilazide. After removal of the tert-butyl protecting group, the resulting N-isoindolinyl (ethynylalanine) derivative is reacted with a series of azides under ‘click conditions’. The click reactions afford an array of N-isoindolinyl- 1,2,3-triazolylalanine derivatives as the free carboxylic acids. Following esterification, the N-isoindolinone protecting group is then transformed into the more easily removable phthaloyl group by selective oxidation

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32

Arnold, DP, RFC Brown, LJ Nitschinsk, P. Perlmutter, and HK Tope. "Derivatives of 4-(Aminomethyl)pyrrole-3-carboxylic Acid." Australian Journal of Chemistry 47, no. 5 (1994): 975. http://dx.doi.org/10.1071/ch9940975.

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33

Brill, Jeffrey H., Bikshandarkoil A. Narayanan, and John P. McCormick. "Selective Determination of Pentafluorobenzyl Ester Derivatives of Carboxylic Acids by GC Using Microwave Plasma and Mass Selective Detection." Applied Spectroscopy 45, no. 10 (1991): 1617–20. http://dx.doi.org/10.1366/0003702914335193.

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A highly selective, sensitive method for determination of carboxylic acids in water has been developed that is based on fluorine-selective gas chromatography (GC) detection of pentafluorobenzyl ester derivatives. The atmospheric-pressure helium microwave-induced plasma detector is well suited for fluorine-specific detection of these derivatives, which were well resolved by capillary GC and displayed a characteristic fragmentation behavior when examined by GC-mass selective detection. For demonstration purposes, a number of carboxylic acids, ranging from C1 to C20, were examined and found to be

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34

Matsumura, Yuriko, and Kaoru Iwai. "pH Behavior of Polymer Complexes between Poly(carboxylic acids) and Poly(acrylamide derivatives) Using a Fluorescence Label Technique." Polymers 11, no. 7 (2019): 1196. http://dx.doi.org/10.3390/polym11071196.

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In order to clarify the local environment during interpolymer complex formation between poly(carboxylic acids) and poly(acrylamide derivatives) with different N-substitutions, a fluorescence label technique was used. 3-(2-propenyl)-9-(4-N,N-dimethylaminophenyl) phenanthrene (VDP) was used as an intramolecular fluorescence probe. All polymers were synthesized by free radical polymerization. Interpolymer complexation was monitored by charge transfer emission from the VDP unit. Both of the poly(carboxylic acids) formed interpolymer complexes with poly(N,N-dimethylacrylamide) (polyDMAM). The micro

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35

Abidov, U. A., S. G. Usmanova, Kh M. Zhamolova, and U. O. Mamatkulova. "SYNTHETIC ACETYLENE CARBOXYLIC ACIDS." RUSSIAN ELECTRONIC SCIENTIFIC JOURNAL 36, no. 2 (2020): 10–17. http://dx.doi.org/10.31563/2308-9644-2020-36-2-10-17.

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The article presents some methods for the synthesis of acetylene mono, dicarbonoaliphatic, aromatic, heterocyclic acids. Among them, some possess antifungal and biological properties. By the interaction of acids or acid chlorides with the corresponding alcohols, esters can be obtained. Their biological properties, as well as some chemical transformations, were studied. Many synthetic acetylenic acids and their derivatives were synthesized mainly by the Grignard reaction and other methods in order to study their physiological activity. Some of them have gained application as a stabilizer of cor

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Liepa, AJ, AJ Liepa, JS Wilkie, JS Wilkie, KN Winzenberg, and KN Winzenberg. "Preparation of Some 1-Alkyl-4-[1-(ethoxyimino)butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylic Acid Ester and Amide Herbicides by Reductive Alkylation of 3,5-Dimethoxybenzoic Acid." Australian Journal of Chemistry 42, no. 8 (1989): 1217. http://dx.doi.org/10.1071/ch9891217.

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Reductive alkylation of 3,5-dimethoxybenzoic acid with haloalkanes afforded the 1-alkyl- 3,5-dimethoxycyclohexa-2,5-diene-1-carboxylic acid derivatives (3a-e) which, upon esterification and hydrolysis, furnished methyl 1-alkyl-3-hydroxy-5-oxocyclohex-3-ene-l-carboxylate derivatives (4f-j). Reaction of (4f-j) with butyric anhydride gave methyl 1-alkyl-4-butyryl- 3-hydroxy-5-oxocyclohex-3-ene-1-carboxylate derivatives (6a-e) which were converted into methyl 1-alkyl-4-[1-( ethoxyimino )butyl]-3-hydroxy-5-oxocyclohex-3-ene-1-carbo xyate derivatives (2a-e). Similarly, the oxime O-ether derivative (

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Lynch, Daniel E., Laura J. Nicholls, Graham Smith, Karl A. Byriel, and Colin H. L. Kennard. "Molecular co-crystals of 2-aminothiazole derivatives." Acta Crystallographica Section B Structural Science 55, no. 5 (1999): 758–66. http://dx.doi.org/10.1107/s0108768199003146.

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A series of molecular adducts of 2-aminothiazole derivatives – 2-aminothiazole, 2-amino-2-thiazoline and 2-aminobenzothiazole with the carboxylic-acid-substituted heterocyclics indole-2-carboxylic acid, N-methylpyrrole-2-carboxylic acid and thiophene-2-carboxylic acid – have been prepared and characterized using X-ray powder diffraction and in five cases by single-crystal X-ray diffraction methods. These five compounds are the adducts of 2-amino-2-thiazolium with indole-2-carboxylate [(C3H7N2S)+(C9H6NO2)−], and N-methylpyrrole-2-carboxylate [(C3H7N2S)+-(C6H6NO2)−], 2-aminobenzothiazolium with

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Shilin, Serhiy, Illya Lenko, Olga Shablykina, and Volodymyr Khilya. "6-Oxyindan-1-ones with amino acid fragments." French-Ukrainian Journal of Chemistry 6, no. 2 (2018): 18–26. http://dx.doi.org/10.17721/fujcv6i2p18-26.

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New indan-1-one derivatives (8 examples) with amino acid fragments were synthesized through the N-acylation of the amino acids by 2-(3-oxo-2,3-dihydro-1H-inden-5-yloxy)acetic acid using the method of activated N-hydroxysuccinimide esters. To obtain corresponding methyl esters (2 examples) two ways were possible: the N-acylation of the amino acid methyl esters by 2-(3-oxo-2,3-dihydro-1-inden-5-yloxy)acetic acid through the activated imidazole derivatives or methylation of the carboxylic function of preformed N-{[(1-oxoindan-6-yl)oxy]acetyl}amino acids.

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Zhivotova, T. S., R. E. Bakirova, S. D. Fazylov, S. K. Kabieva, and T. V. Kryazheva. "Synthesis and Biological Activity of 2,5-Bisubstituted Derivatives of 1,3,4-Thiadiazol-2,5-dithiol." Journal of Chemistry 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/635079.

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By reaction of 1,3,4-thiadiazol-2,5-dithiol with different organohalogens, chlorides of carboxylic acids, acrylic acid derivatives, alkaloids, and secondary amines, various derivatives of 2,5-bi-substituted 1,3,4-thiadiazole were synthesized, and biological properties of some of them were studied.

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Kovács, Rita, Alajos Grün, Sándor Garadnay, István Greiner, and György Keglevich. "“Greener” synthesis of bisphosphonic/dronic acid derivatives." Green Processing and Synthesis 3, no. 2 (2014): 111–16. http://dx.doi.org/10.1515/gps-2013-0107.

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Abstract According to literature, the synthesis of dronic acid derivatives from the corresponding carboxylic acids using phosphorus trichloride and phosphorous acid as the P-reactants is controversial, due to the wide range of molar ratios and diverse conditions. In this minireview, we summarize our results on the clarification of these problems. For example, with zoledronic acid and risedronic acid, we found that, using methanesulfonic acid (MSA) as the solvent, 3.2 equivalents of phosphorus trichloride was enough. Generalizing this optimized method, etidronate, fenidronate, ibandronate and a

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El-Faham, Ayman, Wael N. Hozzein, Mohammad A. M. Wadaan, et al. "Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives." Journal of Chemistry 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/716987.

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Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation. The prepared compounds were characterized by FT-IR, NMR, elemental analysis, and X-ray crystallography for derivatives5b. The synthesized compounds were screened for antimicrobial activity against selected bacteria and fungi. The results revealed that theN-alkyl isatin derivatives were biologically active with different spectrums activity. Most of the 3-hydrazino and 3-thiosemicarbazino isatin derivatives were biologically inactive and

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Lévai, Albert, and József Jekő. "Synthesis of carboxylic acid derivatives of 2-pyrazolines." Arkivoc 2007, no. 1 (2007): 134–45. http://dx.doi.org/10.3998/ark.5550190.0008.114.

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Shida, Yasuo, Takanobu Maejima, Toyozo Takada, and Mitsuo Akiba. "Mass spectra of indole-2-carboxylic acid derivatives." Journal of the Mass Spectrometry Society of Japan 37, no. 1 (1989): 61–67. http://dx.doi.org/10.5702/massspec.37.61.

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Jahyo, Kang, Lee Jae Hyoung, Kim Koan Seong, Jeong Jae Uk, and Pyun Chongsuh. "Convenient preparation of acyltrimethylsilanes from carboxylic acid derivatives." Tetrahedron Letters 28, no. 28 (1987): 3261–62. http://dx.doi.org/10.1016/s0040-4039(00)95487-x.

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Vanotti, Ermes, Marina Caldarelli, Teresa Disingrini, et al. "Regioselective halogenation of aminopyrimidinyl-pyrrole carboxylic acid derivatives." Tetrahedron 65, no. 50 (2009): 10418–23. http://dx.doi.org/10.1016/j.tet.2009.10.030.

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Sandhu, G. K., and N. S. Boparoy. "Diorganotin(IV) Derivatives of Thiophene-2-carboxylic Acid." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 20, no. 7 (1990): 975–88. http://dx.doi.org/10.1080/00945719008048189.

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Kornberg, Brian E., Sham S. Nikam, and Michael F. Rafferty. "Synthesis of novel quinoxaline-5-carboxylic acid derivatives." Journal of Heterocyclic Chemistry 36, no. 5 (1999): 1271–77. http://dx.doi.org/10.1002/jhet.5570360526.

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EGSGAARD, H., and L. CARLSEN. "ChemInform Abstract: Mass Spectrometry of Carboxylic Acid Derivatives." ChemInform 24, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199336337.

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Kato, Shinzi, Toshiaki Murai, and Masaru Ishida. "SELENIUM AND TELLURIUM ISOLOGUES OF CARBOXYLIC ACID DERIVATIVES." Organic Preparations and Procedures International 18, no. 6 (1986): 369–427. http://dx.doi.org/10.1080/00304948609457898.

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Kulinkovich, O. G. "Alkylation of carboxylic acid derivatives with dialkoxytitanacyclopropane reagents." Russian Chemical Bulletin 53, no. 5 (2004): 1065–86. http://dx.doi.org/10.1023/b:rucb.0000041303.52400.ca.

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