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Relevant bibliographies by topics / Carcinogenesis / Dissertations / Theses

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Dissertations / Theses on the topic 'Carcinogenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Solano, Marize de Lourdes Marzo [UNESP]. "Lesões histológicas em ratos Wistar submetidos ao protocolo modificado do bioensaio DMBDD." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/95846.

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2

Fischer, Heléne. "Gene expression in carcinogenesis /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4961-1/.

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3

Toft, Neil John. "MSH2, apoptosis, and carcinogenesis." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/22693.

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Tumour cells which lack DNA mismatch repair are resistant to the cytotoxic effects of DNA methylating agents and Cisplatin. To address whether this resistance is mediated through loss of an <I>MSH2</I>-dependent apoptotic pathway, the apoptotic response of the murine small intestine to DNA methylating agents and Cisplatin was studied. <I>MSH2 </I>was found to play a significant role in the initiation of apoptosis <I>in vivo.</I> The immediate apoptotic response to these agents was <I>p53</I>-dependent in the first 24 hours, however a smaller <I>p53-</I>independent apoptotic response was observ

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4

Silva, Juliana Ferreira da [UNESP]. "Efeitos da temperatura e do mate (Ilex paraguariensis) sobre o processo de carcinogênese de esôfago em ratos wistar machos." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/87778.

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Made available in DSpace on 2014-06-11T19:23:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-09-17Bitstream added on 2014-06-13T19:49:29Z : No. of bitstreams: 1 silva_jf_me_botib.pdf: 326535 bytes, checksum: fe0aa6d59a3acd2eb778f89a8d92390b (MD5)<br>Universidade Estadual Paulista (UNESP)<br>O consumo de mate em altas temperaturas tem sido considerado um fator de risco para o desenvolvimento do carcinoma epidermóide de esôfago (CE) na América do Sul. Desta forma, os efeitos da ingestão de mate sobre danos de DNA e a carcinogênese de esôfago, induzidos pela dietilnitrosamina (DEN) e

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5

Bowman, Rayleen Veronica. "Mechanisms of human bronchial carcinogenesis /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19353.pdf.

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6

TOYOKUNI, SHINYA. "MECHANISMS OF ASBESTOS-INDUCED CARCINOGENESIS." Nagoya University School of Medicine, 2009. http://hdl.handle.net/2237/11331.

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7

Stefanius, K. (Karoliina). "Colorectal carcinogenesis via serrated route." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514293993.

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Abstract Colorectal cancer is the third most common cancer in the developed countries. Originally, development of CRC was thought to proceed by a sequence of steps known as an adenoma-carcinoma sequence. At present CRC is recognized as a disease developing through diverse pathways. Serrated adenocarcinoma represents an endpoint of tumors developing from serrated pathway. This thesis focuses on studying the molecular alterations in serrated adenocarcinoma. Microsatellite instability, hypermethylation of promoter region in DNA repair genes hMLH1 and MGMT, frequency of KRAS and BRAF mutations and

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8

De, Buck Stefan. "Immunoprophylactic approaches against chemical carcinogenesis." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210984.

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9

Cooper, Kumarasen. "Human papillomavirus and cervical carcinogenesis." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306091.

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10

Al-Damouk, Jawdet Dakhel. "Malnutrition and experimental oral carcinogenesis." Thesis, University of Glasgow, 1988. http://theses.gla.ac.uk/2731/.

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The work was undertaken to examine the effects of nutritional deficiencies on cancer induction. Two of the most common and widely distributed nutrients, iron and folic acid, were examined to evaluate the effects of their deficiency on animals. The Syrian golden hamster was the animal model for all experimental work. In the first part of the study an attempt was made to induce iron deficiency in young adult male hamsters by feeding iron deficient diet coupled with repeated venesection of 1.5ml every two weeks. Following twelve weeks on this regime a superficial biopsy was taken, on week 13, fro

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11

Zeki, Sebastian Simon. "Clonal interactions in Barrett's carcinogenesis." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9069.

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Introduction: Barrett’s oesophagus (BO) is a metaplastic premalignant disease which can undergo a metaplasia-‐dysplasia-‐adenocarcinoma pathway. It represents an example of field cancerization by which an area occupied by BO can undergo molecular and genetic changes associated with carcinogenesis without being phenotypically cancerous. Previous work suggested that non-‐cancerous BO contains a monoclonal population. More recent work demonstrated that premalignant Barrett’s fields are polyclonal suggesting that clonal interactions may be important in carcinogenesis. It is the aim of this thes

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12

Hogan, Iain T. D. "The chemical regulation of carcinogenesis." Thesis, University of Bath, 1985. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355115.

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The work outlined in this thesis is concerned with the use of chemical agents in the prevention and cure of cancer. Under this generally broad brief, we examined three topics of considerable interest in this field at the present time. Firstly we investigated the role of three dietary indoles which have been shown to inhibit the induction of cancer by certain procarcinogens, in particular benzo[a]pyrene. In this work we prepared analogues of the dietary indoles with a view to ascertaining their mode of action and increasing their activity. Next we devised a synthesis of dendrodoine, a natural p

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13

Woo, Yong. "Characterizing the Dynamics of Genome Evolution in Tumorigenesis." Fogler Library, University of Maine, 2009. http://www.library.umaine.edu/theses/pdf/WooY2009.pdf.

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14

Bidinotto, Lucas Tadeu [UNESP]. "Efeitos do óleo essencial de Cymbopogon citratus Stapf (Capim-limão) sobre o processo de carcinogênese química em fêmeas BALB/C." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/95911.

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Made available in DSpace on 2014-06-11T19:27:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-02-17Bitstream added on 2014-06-13T19:15:40Z : No. of bitstreams: 1 bidinotto_lt_me_botfm.pdf: 438545 bytes, checksum: 16013851a4d54716162eb93906126f59 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Lemongrass (Cymbopogon citratus STAPF) has been described as a potential chemopreventive agent. Thus, the present study objectives were evaluate the protective effects of oral treatment with lemongrass essential oil (LGEO) on carcinogenesis initiation phase with N-meth

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15

JAFFE, DEBORAH RUTH. "MOUSE SKIN TUMOR INITIATION BY IONIZING RADIATION AND THE DETECTION OF DOMINANT TRANSFORMING GENE(S)." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184146.

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The initiating potential of a range of 4 MeV X-rays was studied using the mouse skin two-stage model of carcinogenesis. A single dose of radiation was followed by promotion with 12-O-tetradecanoyl phorbol-13-acetate (TPA). The effect of TPA on tumor incidence when applied as a single dose 24 hours prior to irradiation was examined. Studies were also designed to investigate the effect of promotion duration on tumor incidence. Animals were promoted with TPA for 10 or 60 weeks. Evidence presented here indicates that ionizing radiation can act as an initiator in this model system. All animals that

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16

Cheong, Edward. "Cox-2 in Barrett's oesophageal carcinogenesis." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426779.

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17

Rees, Bastiaan Paulus van. "Molecular alterations in gastro-esophageal carcinogenesis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64257.

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18

Gao, Meiling. "Role of Sprouty2 in prostate carcinogenesis." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/3090/.

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Prostate cancer (PC) is the most common cancer in men. In the UK alone, there are over 30,000 men diagnosed with PC every year. Loss of SPRY2 and activation of receptor tyrosine kinases are common events in PC. However, the molecular basis of their interaction and clinical impact remains to be fully examined. SPRY2 loss may functionally synergise with aberrant cellular signalling to drive PC and to promote treatment resistant disease. Using a combination of in vitro, pre-clinical in vivo models and clinical PC, this thesis shows the impact of SPRY2 loss upon activation of the ErbB signalling s

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19

Kitson, Sean Leslie. "The mechanism of carcinogenesis by urethane." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242359.

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20

Pitigala-Arachchi, A. J. "Major histocompatibility antigens in oral carcinogenesis." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380226.

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21

Nelson, Adam William. "Estrogen receptor beta modulates prostate carcinogenesis." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267736.

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Prostate cancer (PC) is characterised by dependence upon androgen receptor (AR) as its driving oncogene. When organ-confined, radical treatment can be curative, however there is no cure for advanced, castration-resistant prostate cancer (CRPC). There is therefore a need to better understand the biology of PC, and how influencing AR can modify disease progression. Estrogen is essential for prostate carcinogenesis with evidence from epidemiological, in vitro, human tissue and animal studies. Most suggests that estrogen receptor beta (ERβ) is tumour-suppressive, but trials of ERβ-selective agents

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22

Gunter, Marc James. "Gene-environment interactions in colorectal carcinogenesis." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620513.

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23

Cowling, Lucinda. "Epigenetic dysregulation in cadmium urothelial carcinogenesis." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/13052/.

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The urothelium, the epithelial lining of the bladder, is exposed to urinary-excreted carcinogens from environmental, occupational and dietary sources. These carcinogens include heavy metals such as cadmium. As cadmium is a weak mutagen, this suggests that genetic mechanisms are not responsible for cadmium-induced carcinogenesis. Non-genotoxic carcinogenesis is relatively poorly understood, however recent advances show that epigenetic dysregulation of gene expression may play an important role. The aim of my research was to investigate epigenetic dysregulation as the candidate mechanism underly

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24

Roberts, Kristen M. "Dietary Bioactives and Human Prostate Carcinogenesis." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429195549.

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25

Xu, Jinyu Xu. "Snacking, Childhood Obesity, and Colon Carcinogenesis." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461245235.

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26

Mobley, James Austin. "Oxidative mechanisms of estrogen induced carcinogenesis /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu148819623490807.

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27

Frede, Julia. "Cellular dynamics in Oesophageal Squamous Carcinogenesis." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708817.

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28

Romagnolo, Alberto. "Mechanisms of Skin Biology and Carcinogenesis." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/271940.

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The skin is a vital organ for life; whose primary function is to act as a defensive barrier. Dysfunction in the epidermal barrier of the skin is commonly observed in autosomal recessive congenital ichthyosis (ARCI). The 12R-Lipoxygenase (12R-L) and epidermis-type Lipoxygenase 3 (eLOX-3) pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing. 12R-L KO mice exhibited differential expression of filaggrin, glucosyl ceramide, and ceramide markers, suggesting that they are essential in the proper formation of the epidermi

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29

ABOU, KHOUZAM RAEFA. "New molecular players in gastric carcinogenesis." Doctoral thesis, Università degli studi di Pavia, 2016. http://hdl.handle.net/11571/1203380.

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Gastric cancer (GC) is a heterogeneous disease with two major histological subtypes “intestinal” (IGC) and “diffuse” (DGC). 1-3% of GCs are truly hereditary and are dominated by the Hereditary Diffuse Gastric Cancer (HDGC) syndrome, predisposing to DGC. HDGC is mainly explained by germline alterations in the CDH1 tumor suppressor gene; however, at least 50% of cases remain without a known genetic determinant. It has recently been reported that intron 2 of the CDH1 gene gives rise to a number of non-canonical transcripts, none of which have been investigated in GC patients. Moreover, the applic

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30

Dall'Olmo, Luigi. "New Insights In Experimental Esophageal Carcinogenesis." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422915.

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Gastro-esophageal reflux disease (GERD) is a relevant health problem worldwide. It impairs patients' quality of life and predisposes to intestinal-like esophageal metaplasia (i.e. Barrett's esophagus, BE), that is recognized as the major risk factor for the development of esophageal adenocarcinoma (Eac). The incidence of Eac has dramatically increased since the mid of the 1970s in the USA and Western countries for unknown reasons, while the prognosis of Eac has only slightly been improved. During the same time potent acid suppressors have been introduced for the treatment of GERD. Nowadays t

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31

Mainenti, Pietro [UNESP]. "Carcinogênese quimicamente induzida por DMBA em glândulas salivares submandibulares de ratos (rattus norvegicus)." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/87939.

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32

Minicucci, Eliana Maria [UNESP]. "O papel da proteina p53 e do gene TP53 na carcinogênese bucal quimicamente induzida pela 4NQO em ratos." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/99904.

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33

Grassi, Tony Fernando [UNESP]. "Carcinogênese de mama em modelo experimental de exposição gestacional, juvenil e adulta ao herbicida Diuron [3(3,4-Diclorofenil)1,1, Dimetil uréia] em fêmeas Sprague-Dawley." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/104582.

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34

Meza, Rafael. "Some extensions and applications of multistage carcinogenesis models /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/6750.

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35

Malwade, Santosh. "Shape and quantitative analysis of factor #4 (filopodia) and factor #7 (massive protrusions) in tumorigenic cells." Bowling Green, Ohio : Bowling Green State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1207859857.

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36

Leyk, Williams Malgorzata. "Summarizing FLARE assay images in colon carcinogenesis." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3132.

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Intestinal tract cancer is one of the more common cancers in the United States. While in some individuals a genetic component causes the cancer, the rate of cancer in the remainder of the population is believed to be affected by diet. Since cancer usually develops slowly, the amount of oxidative damage to DNA can be used as a cancer biomarker. This dissertation examines effective ways of analyzing FLARE assay data, which quantiﬁes oxidative damage. The statistical methods will be implemented on data from a FLARE assay experiment, which examines cells from the duodenum and the colon to s

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37

Sova, H. (Henri). "Oxidative stress in breast and gynaecological carcinogenesis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204062.

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Abstract Cancer is the leading cause of death worldwide. Despite the significant research effort, underlying mechanisms of carcinogenic processes are still poorly understood. In recent decades, a group of extremely reactive oxygen metabolites, reactive oxygen species (ROS), have been linked closely to carcinogenesis. Levels of ROS are constantly controlled by antioxidants to ensure stable redox balance in our cells. An aberrant cellular redox balance is thought to be connected to carcinogenesis by inflicting damage to cellular macromolecules and disturbing normal cellular signalling. In this w

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38

Mellick, Albert S. Jr, and n/a. "Tissue Specific Gene Expression Patterning and Carcinogenesis." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20041102.114313.

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Despite significant advances in diagnosis and treatment, breast cancer remains the leading cause of cancer-related deaths in Australian women. Colorectal cancer is the second most common cancer in both males and females; after prostate and breast cancer, respectively, and excluding non-melanocytic skin cancer. Both breast cancer and colorectal cancer follow a common progressive course of illness; presenting (at least initially) with benign symptoms that can be treated by ablation (or removal) of the affected area. Cancer progression is associated with breakdown of tissue barriers (such as base

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39

Munsaka, Melvin S. "Some estimation problems in carcinogenesis risk assessment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ65685.pdf.

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40

Veltman, Joris André. "Chromosomal aberrations during head and neck carcinogenesis." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6943.

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41

Chan, Kwan-yi Queeny. "Molecular studies on endometrial and ovarian carcinogenesis." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634474.

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42

Chang, C. L. "Retinoid signalling in Barrett's metaplasia and carcinogenesis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597456.

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The aim of this research is to investigate whether there is any evidence for a role of RA in the development of Barrett’s metaplasia and subsequent carcinogenesis. First, an <i>ex vivo</i> organ culture system was established in which columnar metaplasia could be induced by exogenous all-trans RA (ATRA) from a squamous tissue, and conversely, squamous metaplasia could be induced from a Barrett’s tissue. Molecular characterisation of these induced-phenotypes was performed with a variety of markers. In addition, the factors that may have contributed to the activation of endogenous RA signalling

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43

Chung, G. T. Y. "Somatic genetic changes in early lung carcinogenesis." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597688.

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Carcinogenesis is a multistep process, and epithelial cancers are preceded by a series of morphologically recognisable pre-invasive lesions that develop over a period of time. Lung cancers arise from morphological steps involving hyperplasia, metaplasia, dysplasia, carcinoma <I>in situ</I>, invasive carcinoma and metastatic carcinoma. Chromosome 3 and <I>p53</I> gene damage are two most common genetic abnormalities found in lung cancer. Loss of chromosome 3p and mutation of <I>p53</I> gene occurred in severe dysplasia, a lesion believed to immediately precede invasive tumour. However, little i

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44

Li, Guangquan. "Stochastic modelling of carcinogenesis : theory and application." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486378.

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Cancer is a group of diseases characterized by autonomous, uncontrollable cell proliferation, evasion of cell death, self-construction of oxygen and nutrient supply and spreading of cancerous cells through metastasis. It is vital to elucidate pathways that underlie the cancer process. Mechanistic cancer models, to this extent, attempt to relate the occurrence: of malignant neoplasm to diverse risk factors such as genetic alterations, susceptibility of individuals and exogenous and endogenous carcinogenic exposures. The main objectives of this thesis are to examine the validity of the two-hit h

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45

陳君怡 and Kwan-yi Queeny Chan. "Molecular studies on endometrial and ovarian carcinogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634474.

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46

Groten, Jenny [Verfasser], Christoph [Akademischer Betreuer] Borner, and Roland [Akademischer Betreuer] Mertelsmann. "Towards simulating carcinogenesis : : the hallmark concept revisited." Freiburg : Universität, 2018. http://d-nb.info/1151046981/34.

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47

Gulati, Abha. "Critical molecular events in early skin carcinogenesis." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/516.

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Background: Cutaneous squamous cell carcinoma (SCC) is the second most common cancer to affect populations of European descent. It is potentially fatal and causes substantial morbidity. Up to 70% of SCC arise from clinically identifiable precancerous lesions, known as actinic keratoses (AK), permitting early diagnosis and intervention. Keratinocyte Intra-epidermal Neoplasia (KIN) are the histological representation of AK. Immunosuppressed organ transplant recipients have 60 – 200 fold higher rates of SCC that are characteristically multiple, aggressive, recurrent and have higher metastatic ten

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48

Singh, Subir. "Role of cytochrome P450 in breast carcinogenesis." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/role-of-cytochrome-p450-in-breast-carcinogenesis(ed2c5c1b-d2e9-458b-acc5-3c320cf22ee6).html.

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Cytochrome P450 enzymes (CYP) are key oxidative enzymes that are crucial in several biological processes, such as metabolism of exogenous and endogenous substances, the biological transformation of drugs and xenobiotics and biosynthesis of steroids and fatty acid. Several CYP have been identified in extra hepatic tissues implying that these enzymes exert other biological functions, which might explain their association with a number of diseases including diabetes, obesity and cancer. Understanding of these functions may provide the platform for the development of new therapeutic approaches and

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49

Costa, Maria Natália Rios Vieira da. "Relevance of MUC1 mucin in gastric carcinogenesis." Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/62170.

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50

Lehman, Teresa Ann. "Studies in human skin epithelial cell carcinogenesis /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487332636474889.

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