Relevant bibliographies by topics / Carcinogenic DMBA

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Carcinogenic DMBA'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Carcinogenic DMBA"

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Sutapa Mukherjee, Archismaan Ghosh, and Madhumita Roy. "Co-Carcinogenicity of Arsenic: Probable Mechanisms." International Journal of Current Microbiology and Applied Sciences 10, no. 11 (2021): 294–305. http://dx.doi.org/10.20546/ijcmas.2021.1011.033.

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Presence of carcinogens, like Polycyclic Aromatic Hydrocarbons (PAH), in the form of cigarette smoke, vehicular emission and industrial emissions in our immediate surroundings is a potent health hazard. Arsenic, a carcinogenic metalloid, omnipresent in the environment, can act as co-carcinogen, where it enhances the carcinogenicity of other carcinogens. In the present study, the co-carcinogenic effect of Arsenic has been investigated, upon the 7,12-dimethylbenz[a]-anthracene (DMBA), a PAH, induced skin cancer model, in Swiss albino mice. Histological analysis revealed earlier development of in
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Morales-Herrero, María, and Isicio Ortega-Medina. "Experimental carcinogenesis with 7,12-dimethylbenz(a)anthrazene (DMBA) and its inhibition with isothi-ocyanates." Journal of Oral Research 11, no. 4 (2022): 1–13. http://dx.doi.org/10.17126/joralres.2022.047.

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Introduction: DMBA is a chemical carcinogen that induces carcinomas within a few weeks of its application. We developed an experimental model of carcinogenesis induced by DMBA dissolved in 0,5% paraffin oil (DMBA-PO), verifying the inhibitory effect of the carcinogenicity of phenyl isothiocyanate (PhITC), phenethyl (PhnITC) and benzyl isothiocyanate (BITC). Material and Methods: For this, 88 hamsters were distributed into three groups: one exposed to DMBA-PO (Group 1, n=12), three subgroups (n=12) exposed to PhITC, PhnITC, BITC and DMBA-PO (Group 2, n=36) and four control subgroups (n=10) that
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Marshall, Milton V., Janice O. Kuhn, Charles F. Torrey, Stuart L. Fischman, and Lewis P. Cancro. "Hamster Cheek Pouch Bioassay of Dentifrices Containing Hydrogen Peroxide and Baking Soda." Journal of the American College of Toxicology 15, no. 1 (1996): 45–61. http://dx.doi.org/10.3109/10915819609008706.

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The objective of this study was to determine the effects of hydrogen peroxide alone and in combination with 7,12-dimethylbenza[a]anthracene (DMBA) in the oral cavity because H2o2, has been implicated as a complete carcinogen or cocarcinogen in two animal models. In the two independent studies, golden Syrian hamsters were used to evaluate the carcinogenic and cocarcinogenic potential of dentifrices containing H2o2 and NaHCO3. In the first study, the cocarcinogenic potential of a dentifrice containing 0.75% H2O2/ 5% baking soda was compared with that of a commercial dentifrice with similar ingre
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Szabo, Laszlo, Richard Molnar, Andras Tomesz, et al. "The effects of flavonoids, green tea polyphenols and coffee on DMBA induced LINE-1 DNA hypomethylation." PLOS ONE 16, no. 4 (2021): e0250157. http://dx.doi.org/10.1371/journal.pone.0250157.

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The intake of carcinogenic and chemopreventive compounds are important nutritional factors related to the development of malignant tumorous diseases. Repetitive long interspersed element-1 (LINE-1) DNA methylation pattern plays a key role in both carcinogenesis and chemoprevention. In our present in vivo animal model, we examined LINE-1 DNA methylation pattern as potential biomarker in the liver, spleen and kidney of mice consuming green tea (Camellia sinensis) extract (catechins 80%), a chinese bayberry (Morella rubra) extract (myricetin 80%), a flavonoid extract (with added resveratrol) and
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Marques Mesquita, Ana Terezinha, Nádia Lages Lima, Mireile S. G. Dos Santos Souza, and Flaviana Dornela Verli. "Estudo das alterações morfológicas causadas pela uretana em modelo de carcinogênese bucal DMBA-induzida." Revista da Faculdade de Odontologia de Porto Alegre 44, no. 1 (2003): 31–35. http://dx.doi.org/10.22456/2177-0018.103137.

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A proposta deste trabalho resultou da necessidade de se avaliar o potencial carcinogênico da uretana, em concentragoes mais baixas, a partir do modelo experimental de carcinogenese bucal DMBA-induzida. Cem hamsters sírios dourados foram separados em cinco grupos experimentais. 0 grupo 1 recebeu aplicações topicas de uretana 0.5% na borda lateral da língua; grupo 2, uretana 6%; grupo 3 uretana 0.5% + DMBA; grupo 4, uretana 6% + DMBA, e o grupo 5 — DMBA (controle positivo). Os dados obtidos mostraram que a uretana a 0.5% e 6% não induziu alterações histolOgicas nos grupos 1 e 2. A formação de ca
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Mirunalini, S., and R. Susmitha. "7, 12- Dimethylbenz[a]anthracene: A potent and multivariant Chemical carcinogen." Research Journal of Biotechnology 18, no. 9 (2023): 247–58. http://dx.doi.org/10.25303/1809rjbt2470258.

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Cancer is currently the second major cause of mortality globally. It is a collection of disorders categorized as abnormal cell development which can infiltrate and can spread to countless sections of the body. It has been essentially brought about by genetic and environmental sources mainly, countless patients have impacted by ecological factors like polycyclic aromatic hydrocarbons (PAHs). However, many PAHs in the ecosystem are generated from natural factors like direct combustion, petroleum and volcanic activity. Among these, 7,12 dimethylbenz[a]anthracene (DMBA) has been widely recognized
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Martínez B., Diana A., Paola Andrea Barato Gómez, Carlos Arturo Iregui Castro, and Jaiver E. Rosas Pérez. "DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition." BioMed Research International 2020 (February 14, 2020): 1–8. http://dx.doi.org/10.1155/2020/1470868.

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Objectives. To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters’ right buccal pouches in group A (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n = 4) were painted with mineral oil only. Two animals were sacrificed every three weeks to obtain histological samples and to evaluate pathological abnormalities. After 12 wee
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Moody, Joanna D., Peter P. Fu, James P. Freeman, and Carl E. Cerniglia. "Regio- and Stereoselective Metabolism of 7,12-Dimethylbenz[a]anthracene by Mycobacterium vanbaalenii PYR-1." Applied and Environmental Microbiology 69, no. 7 (2003): 3924–31. http://dx.doi.org/10.1128/aem.69.7.3924-3931.2003.

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ABSTRACT The degradation of 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogenic polycyclic aromatic hydrocarbon, by cultures of Mycobacterium vanbaalenii PYR-1 was studied. When M. vanbaalenii PYR-1 was grown in the presence of DMBA for 136 h, high-pressure liquid chromatography (HPLC) analysis showed the presence of four ethyl acetate-extractable compounds and unutilized substrate. Characterization of the metabolites by mass and nuclear magnetic resonance spectrometry indicated initial attack at the C-5 and C-6 positions and on the methyl group attached to C-7 of DMBA. The metabolites were
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Juanda Surbakti, Bima, Vivi Mardina, and Beni Al Fajar. "Effect of Sphagneticola Trilobata Extract on Histological Wistar Rat Kidney Induced by DMBA." International Journal of Engineering, Science and Information Technology 1, no. 3 (2021): 28–34. http://dx.doi.org/10.52088/ijesty.v1i3.82.

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One factor can trigger the growth and development of cancer cells is free radicals that are from carcinogenic compounds such as dimethylbenz (α) anthracene (DMBA). The use of plant extracts as a preventive or curative in cases of tumors/cancer has been reported, however there is no reports about the in vivo study for Sphagneticola trilobata plant. S. trilobata is an herbal plant that has pharmacological activities, potential to be developed as anticancer agent. This study aims to examine the anticancer effect of the methanol extract of S. trilobata leaves using histology observation on Wistar
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Xin, Jian, and Yitai Shang. "Alternariol alleviates breast carcinoma by inhibiting cellular proliferation correlated with increased apoptotic events in rats." European Journal of Inflammation 20 (January 2022): 1721727X2211394. http://dx.doi.org/10.1177/1721727x221139485.

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The breast cancer is most frequently diagnosed cancer in the women worldwide. Our study investigated the anticancer effect of alternariol, a secondary metabolite originated from endophytic fungi, against DMBA induced breast carcinoma on Wistar rats. The toxicity study investigated the LD50 and the subsequent doses of alternariol for the carcinogenic study. The breast cancer was developed in rats via induction of DMBA (5 mg/kg, i.v.) and the carcinogenic study was continued for 24 weeks. The induction of breast cancer and the chemotherapeutic effect of alternariol were assessed through histopat
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Dissertations / Theses on the topic "Carcinogenic DMBA"

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Pieroli, Dayse Aparecida. ""Análise quantitativa das regiões organizadoras nucleolares (NORs) em carcinomas epidermóides desenvolvidos em hamsters a partir do modelo DMBA-indução com agentes clareadores dentais"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/23/23134/tde-22102003-110736/.

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RESUMO A grande prevalência de câncer bucal está relacionada à ação de agentes e de fatores físicos e químicos. As substâncias químicas têm grande importância na indução de cânceres em humanos. Existe grande preocupação em relação aos agentes clareadores à base de peróxido de carbamida a 10%, usados com freqüência na técnica de clareamento caseiro de dentes vitalizados. A preocupação deve-se ao potencial carcinogênico dessas substâncias. Com o efeito somatório sobre as células, toda e qualquer substância deve ser avaliada quanto ao seu potencial carcinogênico sobre a mucosa bucal. Com a int
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Mori, Lincon Jo. "Efeitos morfológicos, histológicos e moleculares dos moduladores seletivos dos receptores de estrogênios tamoxifeno e raloxifeno na prevenção primária de tumores mamários quimicamente induzidos em ratas." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-19022009-132827/.

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O câncer de mama é a neoplasia mais comum na população feminina, representando até um terço dos novos diagnósticos de neoplasia nessa população em algumas regiões do mundo. A prevenção primária ou secundária constitui a pedra fundamental no controle do câncer de mama; depende da identificação dos determinantes da doença, em termos de iniciação e promoção. Aproximadamente, 48.930 novos casos de câncer de mama são detectados anualmente no Brasil, tornando-se um sério problema de saúde pública. O objetivo primário deste estudo foi avaliar a ação e diferenças de dois SERMs, tamoxifeno (TAM) e ralo
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Pasqualini, Catherine. "Controle dopaminergique de la secretion de prolactine au cours du cycle strien chez la rate. Perturbations apportees a ce controle par un carcinogene mammaire, le 7,12-dimethylbenz(a)anthracene (dmba)." Paris 6, 1988. http://www.theses.fr/1988PA066699.

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Le dmba est le carcinogene chimique le plus largement utilise pour induire des tumeurs mammaires chez la rate. Il est apparu que celui-ci outre une action mutagene directe sur les cellules canaliculaire de l'epithelium mammaire pouvait avoir une action stimulante sur la secretion preovulatoire de prolactine (prl) chez les rates de souche sprague-dawley (sd). Or la prl joue un role determinant dans le developpement et la croissance des tumeurs mammaires chez la rate. Nous nous sommes attaches a rechercher les actions du carcinogene sur l'axe hypothalamo-hypophysaire qui pourraient rendre compte
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Deghan, Manshadi Shaidah. "The Effects of Folic Acid Supplementation on Mammary Tumor Progression in the DMBA-carcinogen Animal Model." Thesis, 2011. http://hdl.handle.net/1807/30572.

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Folate intake in North America has drastically increased over the past decade due to folic acid fortification and widespread supplemental use. The role of folate in breast cancer is highly controversial and the effects of folic acid supplementation on breast cancer patients are currently unknown. An animal study was performed to determine the effects of folic acid supplementation on the progression of the mammary tumors in the DMBA-carcinogen model. Folic acid supplementation was associated with more rapid sentinel tumor progression and with higher sentinel tumor weight, volume, and area, alth
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Books on the topic "Carcinogenic DMBA"

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Buckner, Carly. The effects of chronic oral low level melatonin in circadian disrupted wistar rats who received the carcinogen DMBA. Laurentian University, 2003.

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Book chapters on the topic "Carcinogenic DMBA"

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Aidoo, Anane, and Mugimane G. Manjanatha. "Influence of dietary Soy Isoflavones Genistein and Daidzein on Genotoxicity and Mammary Carcinogenicity in Rats Exposed to the Model Carcinogen 7,12-Dimethylbenz[a]anthracene (DMBA)." In Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9800-9_7.

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Briant, C. E., O. Johnson, D. W. Jones, and J. D. Shaw. "Stereochemistry of methyl and methoxy substituents in polycyclic hydrocarbons." In Organic Crystal Chemistry. Oxford University PressOxford, 1991. http://dx.doi.org/10.1093/oso/9780198553830.003.0009.

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Abstract The molecular sites of methyl, methoxy and other simple substituents can have a marked influence on the biological activity of polycyclic aromatic hydrocarbons (PAH). Thus the carcinogenic activities of the monomethyl-(MBA), dimethyl-(DMBA) and polymethylbenz[a]anthracenes range from the negligible in 2-MBA or slight in-1,12-DMBA to the extremely potent in 7-MBA or 7,12-DMBA, even though the structure differences are relatively small. Much the same applies to substitution in phenanthrenes (Johnson et al., 1989), benzfluoranthenes and other PAH.
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José Soto-Castillo, Juan, and Isicio Ortega-Medina. "Experimental Carcinogenesis with 7,12-Dimethylbenz(a)Anthrazene (DMBA) and Its Inhibition with Extra Virgin Olive Oil and a Diet of Mature Olives (Picual Variety)." In Olive Oil - New Perspectives and Applications [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96514.

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7,12-Dimethylbenz(a)anthrazene (DMBA) is a carcinogen that induces carcinomas within a few weeks of application. Forty-four male hamsters were divided into four groups: DMBA dissolved in paraffin oil (DMBA-PO), DMBA dissolved in olive oil (DMBA-OO), paraffin oil and olive oil. Their mouths were swabbed daily with paraffin oil or extra virgin olive oil alternatively for the first two weeks, during the biweekly application of DMBA at 0.5% diluted in paraffin oil or olive oil for five weeks and daily until the twentieth week. The animals in the DMBA-OO and olive oil groups received an additional
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Ayu Oktavianie A. Pratama, Dyah. "Molecular Histopathology of Mammary Carcinogenesis as Approach to Cancer Prediction and Prevention." In Molecular Histopathology and Cytopathology [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.110840.

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Breast/mammary cancer is the most frequent type of cancer and the leading cause of cancer deaths in humans and animals worldwide. The incidence of mammary cancer is continuously increasing worldwide. This increasing trend is attributed partly to the little information on the early changes occurring during mammary gland carcinogenesis. The lack of molecular information on mammary carcinogenesis has impeded the identification of clinically relevant tumor markers beyond histopathology and the introduction of new therapeutic concepts. Numerous factors, molecular and cellular pathways are involved
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Wells, R. L., T. W. Sneider, and M. M. Elkind. "REVERSAL OF KILLING AND TRANSFORMATION DUE TO THE CARCINOGEN DMBA IN C3H 10T1/2 CELLS BY POST-TREATMENT WITH DMBA AND NAPHTHOFLAVONE." In Radiation Research: A Twentieth-century Perspective. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-12-168561-4.51154-9.

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Conference papers on the topic "Carcinogenic DMBA"

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Oraevsky, Alexander, Elena V. Savateeva, Alexander A. Karabutov, et al. "Application of the confocal opto-acoustic tomography in detection of squamous epithelial carcinoma at early stages." In In Vivo optical Imaging at the NIH. Optica Publishing Group, 1999. http://dx.doi.org/10.1364/ivoi.1999.dis153.

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Confocal opto-acoustic transducer (COAT) was developed and applied for detection of early stages of squamous cell carcinoma in hamster model of oral cancer. COAT is a novel imaging modality capable of detecting profiles of wide-band ultrasonic transients at the site of pulsed laser irradiation. Animal model of oral cancer used Syrian golden hamsters treated with carcinogenic agent, DMBA (9,10-Dimethyl-1,2-Benzanthracene). Opto-acoustic tomography was applied to visualize the course of cancer development from normal to displasia, to carcinoma in situ, to invasive carcinoma. Correlation of the o
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