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Journal articles on the topic 'Cardiac Glycosides/pharmacology'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Heller, Michael. "Cardiac glycosides." Biochemical Pharmacology 40, no. 5 (1990): 919–25. http://dx.doi.org/10.1016/0006-2952(90)90475-z.

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2

Ashutosh Pathak, Priya Awasthi, Umair Ahmad, et al. "Overview Study on Characterisation Chemistry and Pharmacology of Digitalis Glycosides." Journal of Science Innovations and Nature of Earth 5, no. 1 (2025): 23–28. https://doi.org/10.59436/jsiane.302.2583-2093.

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Medicinal plants influence human health worldwide and are an integral part of the ecology and environment. Pharmacologically, they have been used to address a number of different ailments in the past. The healing value of plants is attributed to the amount of active chemicals present in their different portions. This review aims to present a current assessment of cardiac glycosides present in African medicinal plants as potentially beneficial treatments. Google, Google Scholar, PubMed, Medline, Research Gate, Web of Sciences, ScienceDirect, and SciFinder were among the online resources used in

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3

Tamura, Masaaki, Hirotoshi Utsunomiya, Misa Nakamura, and Erwin J. Landon. "Effect of dietary cardiac glycosides on blood pressure regulation in rats." Canadian Journal of Physiology and Pharmacology 78, no. 7 (2000): 548–56. http://dx.doi.org/10.1139/y00-023.

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To investigate the possible physiological significance of dietary cardiac glycosides in blood pressure regulation, the blood pressure of normal Sprague Dawley rats raised on a regular diet, which naturally contains large amounts of Na+-pump inhibitors, was compared with that of rats on a purified synthetic diet, which contains no Na+-pump specific inhibitors, and with that of rats on a synthetic diet supplemented with 10 µg·mL-1 ouabain or 10 µg·mL-1 convallatoxin in the drinking water. After 6 weeks on the synthetic diet, the systolic blood pressure in the synthetic diet group was significant

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4

Radford, DJ, AD Gillies, JA Hinds, and P. Duffy. "Naturally occurring cardiac glycosides." Journal of Ethnopharmacology 19, no. 3 (1987): 336–37. http://dx.doi.org/10.1016/0378-8741(87)90017-1.

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5

Mebs, D. "Cardiac Glycosides; Part 2: Pharmacokinetics and Clinical Pharmacology, Handbook of experimental Pharmacology." Toxicon 23, no. 2 (1985): 355. http://dx.doi.org/10.1016/0041-0101(85)90162-x.

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6

Dobbs, R. John, Catherine J. A. OʼNeill, Arvind A. Deshmukh, Paul W. Nicholson, and Sylvia M. Dobbs. "Serum Concentration Monitoring of Cardiac Glycosides." Clinical Pharmacokinetics 20, no. 3 (1991): 175–93. http://dx.doi.org/10.2165/00003088-199120030-00001.

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7

Verma, Kapil Kumar, Akanksha Sharma, Hans Raj, and Bhopesh Kumar. "A comprehensive review on traditional uses, chemical compositions and pharmacology properties of Achyranthes aspera (Amaranthaceae)." Journal of Drug Delivery and Therapeutics 11, no. 2-S (2021): 143–49. http://dx.doi.org/10.22270/jddt.v11i2-s.4789.

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Achyranthes aspera plant is very useful for the cure and treatment of various diseases of human beings. Different parts of the plants is used to cure various diseases like leprosy, asthma, arthritis, wound, snakebite, dermatological diseases, cardiac disease, kidney stone, gynecological disorder, malaria, gonorrhea, pneumonia, dysentery, rabies, toothache, etc. Phytochemistry, pharmacological activities, diseases, traditional uses of the Achyranthes aspera may explain briefly in review articles with in-vivo and in-vitro studies. This article provided the complete latest information on the Achy

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8

Joubert, P. H. "Are all cardiac glycosides pharmacodynamically similar?" European Journal of Clinical Pharmacology 39, no. 4 (1990): 317–20. http://dx.doi.org/10.1007/bf00315402.

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9

&NA;. "Cardiac glycosides interact with many drugs." Drugs & Therapy Perspectives 6, no. 3 (1995): 11–14. http://dx.doi.org/10.2165/00042310-199506030-00006.

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10

Antman, Elliott M., J. Malcolm O. Arnold, Peter L. Friedman, Harvey White, Marie Bosak, and Thomas W. Smith. "Drug Interactions with Cardiac Glycosides." Journal of Cardiovascular Pharmacology 9, no. 5 (1987): 622–27. http://dx.doi.org/10.1097/00005344-198705000-00017.

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11

Magnani, Bruno, and Pier Luigi Malini. "Cardiac Glycosides Drug Interactions of Clinical Significance." Drug Safety 12, no. 2 (1995): 97–109. http://dx.doi.org/10.2165/00002018-199512020-00003.

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12

Smyth, D. D., J. F. Templeton, V. P. Sashi Kumar, Y. Yan, W. Widajewicz, and F. S. LaBella. "Digitaloid pregnanes promote potassium-sparing diuresis in the guinea pig." Canadian Journal of Physiology and Pharmacology 70, no. 5 (1992): 723–27. http://dx.doi.org/10.1139/y92-095.

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The synthesis of 17α-acetoxy-3β-[(β-D-glucopyranosyl)oxy]-6α-methylpregn-4-en-20-one, the glucoside of medroxyprogesterone acetate (MPA-glu), is described. MPA-glu and 14-amino-20β-hydroxy-3β-[(α-L-rhamnopyranosyl)oxy]-5β,14β-pregnane (LND 623), pregnane glycosides that bind to the digitalis receptor, and digoxin, a cardiac glycoside, were infused intravenously into the anesthetized guinea pig. Each of the three steroids significantly enhanced urinary volume and sodium excretion without affecting blood pressure and creatinine clearance. Potassium excretion was markedly enhanced by digoxin but

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13

Akera, Tai. "Mechanisms of cardiac actions of digitalis glycosides and altered glycoside-sensitivity of the heart." Japanese Journal of Pharmacology 39 (1985): 5–6. http://dx.doi.org/10.1016/s0021-5198(19)63237-3.

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14

Deryabin, Pavel I., Alla N. Shatrova, and Aleksandra V. Borodkina. "Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides." Cellular and Molecular Life Sciences 78, no. 23 (2021): 7757–76. http://dx.doi.org/10.1007/s00018-021-03980-x.

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AbstractTargeted elimination of senescent cells, senolysis, is one of the core trends in the anti-aging therapy. Cardiac glycosides were recently proved to be a broad-spectrum senolytics. Here we tested senolytic properties of cardiac glycosides towards human mesenchymal stem cells (hMSCs). Cardiac glycosides had no senolytic ability towards senescent hMSCs of various origins. Using biological and bioinformatic approaches we compared senescence development in ‘cardiac glycosides-sensitive’ A549 and ‘-insensitive’ hMSCs. The absence of senolysis was found to be mediated by the effective potassi

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15

Woods, K. L. "II. THE MODE OF ACTION OF CARDIAC GLYCOSIDES." Journal of Clinical Pharmacy and Therapeutics 11, no. 1 (1986): 11–13. http://dx.doi.org/10.1111/j.1365-2710.1986.tb00823.x.

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16

Prassas, Ioannis, and Eleftherios P. Diamandis. "Novel therapeutic applications of cardiac glycosides." Nature Reviews Drug Discovery 7, no. 11 (2008): 926–35. http://dx.doi.org/10.1038/nrd2682.

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17

Takechi, Masayuki, Kyoko Doi, and Yoshiki Wakayama. "Biological activities of synthetic saponins and cardiac glycosides." Phytotherapy Research 17, no. 1 (2003): 83–85. http://dx.doi.org/10.1002/ptr.1081.

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18

Abd El-Mawla, AhmedM A. "Cardiac glycosides from shoot cultures ofCryptostegia grandiflora." Pharmacognosy Research 2, no. 1 (2010): 15. http://dx.doi.org/10.4103/0974-8490.60583.

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19

Ali, Esmail Al-Snafi. "The chemical constituents and pharmacological activities of Cymbopagon schoenanthus: A review." Chemistry Research Journal 1, no. 5 (2016): 53–61. https://doi.org/10.5281/zenodo.13970341.

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The chemical analysis of<em> Cymbopogon schoenanthus</em> showed that it contained  tannins,  saponins, saponin glycosides,  flavonoids, alkaloids, triterpens, balsams, cardiac glycosides,  glycosides,  steroids and volatile oils. The previous pharmacological effects of<em> Cymbopogon schoenanthus </em>showed that it exerted<em> </em>antioxidant, antimicrobial, anthelmintic, insecticidal, protective, acetylcholinesterase inhibitory activity and other pharmacological effects. This study was designed to highlight the chemical constituents and pharmacological effects of <

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20

Ali, Esmail Al-Snafi. "The contents and Pharmacological Importance of Corchorus capsularis: A Review." Chemistry Research Journal 1, no. 6 (2016): 9–16. https://doi.org/10.5281/zenodo.13957405.

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Seeds of <em>Corchorus capsularis </em>contained cardiac glycosides, corchorin, corchortoxin helveticoside, corchoroside A and B, biosides, olitoriside,  erysimoside, strophantidol glycosides, oliogosaccaride and olitoriside; while leaves contained flavonoids, triterpenes, saponins, glucoside, capsularin steroids and many other secondary  metabolites. The pharmacological studied revealed that te plant possessed cardiac, antioxidant,   antiinflammmatory, analgesic, antipyretic, antimicrobial, insecticidal and many other pharmacological effects.  This review was designed

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21

Gul, Muhammad Adnan, Sidra, Sidra Batool, Bibi Fatima, Ali Rehman, Samina Yaqoob, et al. "A review on the ethnobotany, phytochemistry, pharmacology and nutritional composition of Cucurbita pepo L." Journal of Phytopharmacology 6, no. 2 (2017): 133–39. http://dx.doi.org/10.31254/phyto.2017.6211.

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Cucurbita pepo L. is widely used as a vegetable all around the globe. This review aimed at forming a relation between the traditional uses, phytochemistry, pharmacology and nutritional composition of C. pepo. Traditionally this plant is used in Africa and Asia for the treatment of different diseases including fever, whopping cough, urinary problems, anti-scorbutic, hyperplasia, rheumatism, hemorrhoid, miscarriage, prostate cancer, constipation and blindness. Therapeutically, C. pepo is effective in antibacterial, antioxidant, antitumor, hypoglycemic (anti diabetic) and hypolipidemic activities

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22

Diederich, Marc, Florian Muller, and Claudia Cerella. "Cardiac glycosides: From molecular targets to immunogenic cell death." Biochemical Pharmacology 125 (February 2017): 1–11. http://dx.doi.org/10.1016/j.bcp.2016.08.017.

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23

Kumar, Arvind, Tanmoy De, Amrita Mishra, and ArunK Mishra. "Oleandrin: A cardiac glycosides with potent cytotoxicity." Pharmacognosy Reviews 7, no. 14 (2013): 131. http://dx.doi.org/10.4103/0973-7847.120512.

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24

Scholtysik, G., R. Salzmann, and W. Gerber. "Interaction of DPI 201–106 with Cardiac Glycosides." Journal of Cardiovascular Pharmacology 13, no. 2 (1989): 342–47. http://dx.doi.org/10.1097/00005344-198902000-00026.

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25

Li, Xiao-San, Meng-Jie Hu, Jie Liu, et al. "Cardiac glycosides from the bark of Antiaris toxicaria." Fitoterapia 97 (September 2014): 71–77. http://dx.doi.org/10.1016/j.fitote.2014.05.013.

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26

Jensen, Kjell Briseid. "Paper Chromatography of Cardiac Glycosides and Aglyeones from Digitalis Purpurea." Acta Pharmacologica et Toxicologica 9, no. 2 (2009): 99–108. http://dx.doi.org/10.1111/j.1600-0773.1953.tb02934.x.

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27

Yajima, Michio, Yoshihiro Hotta, and Kazumi Takeya. "Influence of nifedipine on the positive inotropic effects of cardiac glycosides." Japanese Journal of Pharmacology 39 (1985): 297. http://dx.doi.org/10.1016/s0021-5198(19)63758-3.

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28

Biagi, G. L., A. M. Barbaro, M. C. Guerra, G. Cantelli Forti, and P. A. Borea. "Influence of lipophilic character on the acute toxicity of cardiac glycosides." Pharmacological Research Communications 20 (September 1988): 41. http://dx.doi.org/10.1016/s0031-6989(88)80171-1.

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29

Slingerland, M., C. Cerella, H. J. Guchelaar, M. Diederich, and H. Gelderblom. "Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials." Investigational New Drugs 31, no. 4 (2013): 1087–94. http://dx.doi.org/10.1007/s10637-013-9984-1.

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30

Saxena, V., and S. Chaturvedi. "Cardiac Glycosides from the Roots ofStreblus asper." Planta Medica 51, no. 04 (1985): 343–44. http://dx.doi.org/10.1055/s-2007-969509.

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31

Tian, Dan-Mei, Huo-Yun Cheng, Miao-Miao Jiang, Wei-Zai Shen, Jin-Shan Tang, and Xin-Sheng Yao. "Cardiac Glycosides from the Seeds ofThevetia peruviana." Journal of Natural Products 79, no. 1 (2015): 38–50. http://dx.doi.org/10.1021/acs.jnatprod.5b00611.

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32

Imre, Zeliha, and Türkan Yurdun. "Cardiac Glycosides from the Seeds ofDigitalis cariensis." Planta Medica 54, no. 06 (1988): 529–31. http://dx.doi.org/10.1055/s-2006-962539.

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33

Jensen., Kjell Briseid. "Isolation by Paper Chromatography of Unknown Glycosides from Digitalis Purpurea and their Transformation into the Known Cardiac Glycosides." Acta Pharmacologica et Toxicologica 12, no. 1 (2009): 20–26. http://dx.doi.org/10.1111/j.1600-0773.1956.tb01358.x.

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34

Balderas-López, José Luis, Simone Barbonetti, Erika Lizbeth Pineda-Rosas, José Carlos Tavares-Carvalho, and Andrés Navarrete. "Cardiac glycosides from Cascabela thevetioides by HPLC-MS analysis." Revista Brasileira de Farmacognosia 29, no. 4 (2019): 441–44. http://dx.doi.org/10.1016/j.bjp.2019.04.008.

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35

Sener, B., N. Evren, and M. Ozguven. "Determination of some cardiac glycosides by high-performance liquid chromatography." Journal of Ethnopharmacology 23, no. 2-3 (1988): 359. http://dx.doi.org/10.1016/0378-8741(88)90091-8.

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36

Tong, Alex CY, Carla AD Maria, Stephen Rattigan, and Michael G. Clark. "Na+ channel and Na+-K+ ATPase involvement in norepinephrine- and veratridine-stimulated metabolism in perfused rat hind limb." Canadian Journal of Physiology and Pharmacology 77, no. 5 (1999): 350–57. http://dx.doi.org/10.1139/y99-036.

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In the constant flow perfused rat hind limb, norepinephrine (NE) evoked increases in oxygen uptake ([Formula: see text]o2) and lactate efflux (LE) were inhibited by the cardiac glycoside ouabain (1 mM), without interrupting the NE-mediated vasoconstriction. The membrane labilizer veratridine, previously shown to increase [Formula: see text]o2 and LE, without increasing perfusion pressure, was also shown to be inhibited by the cardiac glycoside ouabain, as well as by the ouabain analogues digitoxin and digoxin. The stimulatory actions of veratridine on [Formula: see text]o2 were inhibitable by

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37

Tawfik, Hoda, Alanna A. L. Fox, and Kurt Greeff. "Comparative studies of some semisynthetic K-strophanthins with natural cardiac glycosides." Biochemical Pharmacology 34, no. 14 (1985): 2541–47. http://dx.doi.org/10.1016/0006-2952(85)90540-4.

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38

Johansson, Senia, Petra Lindholm, Joachim Gullbo, Rolf Larsson, Lars Bohlin, and Per Claeson. "Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells." Anti-Cancer Drugs 12, no. 5 (2001): 475–83. http://dx.doi.org/10.1097/00001813-200106000-00009.

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39

Kennedy, Richard H., Tai Akera, and Theodore M. Brody. "Suppression of positive inotropic and toxic effects of cardiac glycosides by amiloride." European Journal of Pharmacology 115, no. 2-3 (1985): 199–210. http://dx.doi.org/10.1016/0014-2999(85)90692-2.

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40

Duan, Qiming, Yunhui Xu, Pauline V. Marck, Jennifer Kalisz, Eric E. Morgan, and Sandrine V. Pierre. "Preconditioning and Postconditioning by Cardiac Glycosides in the Mouse Heart." Journal of Cardiovascular Pharmacology 71, no. 2 (2018): 95–103. http://dx.doi.org/10.1097/fjc.0000000000000549.

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41

Patel, Seema. "Plant-derived cardiac glycosides: Role in heart ailments and cancer management." Biomedicine & Pharmacotherapy 84 (December 2016): 1036–41. http://dx.doi.org/10.1016/j.biopha.2016.10.030.

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42

Stuhlemmer, Ursel, Wolfgang Kreis, Marina Eisenbeiss, and Ernst Reinhard. "Cardiac Glycosides in Partly Submerged Shoots ofDigitalis lanata*." Planta Medica 59, no. 06 (1993): 539–45. http://dx.doi.org/10.1055/s-2006-959757.

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43

Ethiraj, Sumathi, and Vandana Sridar. "PHYTOCHEMICAL SCREENING, ANTIOXIDANT ACTIVITY AND EXTRACTION OF ACTIVE COMPOUND (ANONAINE) FROM FRUIT PEEL EXTRACT OF ANNONA RETICULATA L." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 372. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27838.

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Objective: The main objective of this study was to analyze the phytochemical constituents, total phenol, total flavonoid, alkaloid content, in vitro antioxidant activity and high-performance liquid chromatography (HPLC) analysis of anonaine compound from the fruit peel extract of Annona reticulata L.Methods: Preliminary phytochemical analysis for alkaloids, cardiac glycosides, flavonoids, glycosides, phenols, saponins, steroids, tannins, and terpenoids was studied. Quantitative phytochemical analysis for total phenolics, total flavonoids and alkaloids was determined according to standard proto

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44

Adeyemi, Mariam, Olutayo Shokunbi, and Osilesi Odutola. "Qualitative and Quantitative Phytochemical Analysis of Methanol Extracts of Phragmanthera incana (schum) Leaves Parasitized on South-West-Nigeria Host Trees." CURRENT TRENDS IN LIFE SCIENCES RESEARCH 1, no. 2 (2022): 125–33. http://dx.doi.org/10.61867/pcub.v1i2b.036.

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Phragmanthera incana (Schum), a specie of mistletoe, belonging to the family Loranthaceae, is a hemi-parasitic plant growing on trees in South-Western part of Nigeria. The phytochemical constituents of P. incana from four host trees; Psidium guajava (guava), Cola acuminata (kolanut), Anacardium occidentale (cashew) and Mangifera indica (mango) were analysed qualitatively and quantitatively following standard protocols. The Qualitative screening showed the presence of tannins, anthraquinone, flavonoids, phenols, reducing sugar, cardiac glycosides, terpernoids, saponin and steroids in all the fo

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45

Hou, Yani, Congshan Shang, Tingting Meng, and Wei Lou. "Anticancer potential of cardiac glycosides and steroid-azole hybrids." Steroids 171 (July 2021): 108852. http://dx.doi.org/10.1016/j.steroids.2021.108852.

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46

Huang, Mingjin, Shoumao Shen, Chunli Luo, and Yan Ren. "Genus Periploca (Apocynaceae): A Review of Its Classification, Phytochemistry, Biological Activities and Toxicology." Molecules 24, no. 15 (2019): 2749. http://dx.doi.org/10.3390/molecules24152749.

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The genus Periploca belongs to the family Apocynaceae, which is composed of approximately ten species of plants according to incomplete statistics. Most of these plants serve as folk medicines with a long history, especially Periploca sepium and Periploca forrestii. The botanical classifications, chemical constituents, biological activities and toxicities of the genus Periploca were summarized in the literature from 1897 to early 2019. Though the botanical classification of this genus is controversial, these species are well-known to be rich sources of diverse and complex natural products—abov

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47

Lopatina, Ekaterina V., Anna V. Kipenko, Natalia A. Pasatetskaya, Valentina A. Penniyaynen, and Boris V. Krylov. "Modulation of the transducer function of Na+,K+-ATPase: new mechanism of heart remodeling." Canadian Journal of Physiology and Pharmacology 94, no. 10 (2016): 1110–16. http://dx.doi.org/10.1139/cjpp-2015-0577.

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Endogenous digitalis-like factors were found in the mammalian and human blood. It was the starting point for the elucidation of the new non-pumping function of the Na+,K+-ATPase. It was previously well known that Na+,K+-ATPase is a pharmacological target receptor for cardiac glycosides (J.C. Skou. 1957. Biochim. Biophys. Acta, 23: 394–401). We have investigated the trophotropic effects of such agents as ouabain, epinephrine, norepinephrine, atenolol, and comenic acid using the organotypic tissue culture combined with the reconstruction of optical cross sections and confocal microscopy. It was

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48

Moffat, A. C. "Interpretation of Post Mortem Serum Levels of Cardiac Glycosides after Suspected Overdosage." Acta Pharmacologica et Toxicologica 35, no. 5 (2009): 386–94. http://dx.doi.org/10.1111/j.1600-0773.1974.tb00759.x.

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49

Östling, Gustaf. "Determination of Cumulative Effect and Elimination of Cardiac Glycosides by Infusion Tests." Acta Pharmacologica et Toxicologica 3, no. 3 (2009): 275–90. http://dx.doi.org/10.1111/j.1600-0773.1947.tb02656.x.

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50

Geng, Xinran, Fangfang Wang, Danmei Tian, et al. "Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction." Biochemical Pharmacology 182 (December 2020): 114226. http://dx.doi.org/10.1016/j.bcp.2020.114226.

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