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Relevant bibliographies by topics / Cardiac injury / Dissertations / Theses

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Dissertations / Theses on the topic 'Cardiac injury'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Bourke, L. T. "Cardiac injury in lupus." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1458423/.

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Systemic lupus erythematosus (SLE) carries a significantly enhanced risk of developing cardiovascular disease (CVD) and remains a leading cause of death in these patients, accounting for ~25% of all causes of mortality. Although there is clear evidence li nking accelerated atherosclerosis to SLE (and consequently an increase in cardiovascular events), another factor that may contribute to CVD related morbidity and mortality is reperfusion injury that occurs post - ischaemia. This is termed ischaemic / reperfu sion (I/R) injury and is a known important contributor to the size of the eventual in

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2

Wall, Johanna Martine. "Trauma-induced secondary cardiac injury." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/43998.

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Trauma-induced secondary cardiac injury (TISCI) represents an under recognised complication of severe injury with haemorrhage. A limited number of clinical studies have supported the development of adverse cardiac events, such as arrhythmia, in association with biomarker proven TISCI. Pre-clinical studies using small animal models have provided insights into potential mechanisms and key effector molecules involved in the development of TISCI, but there remains a general lack of understanding regarding the in vivo functional implications of this indirect cardiac injury resulting from trauma-hae

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3

De’Ath, Henry D. I. "Trauma associated cardiac injury & dysfunction." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8466.

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The existence of a trauma induced secondary cardiac injury (TISCI) remains in doubt. The risk factors and pathological processes that lead to its development are not known, whilst the effects of TISCI on injured patient outcome are uncertain. Concurrently, the incidence of coronary heart disease (CHD) in a trauma population and its influence on mortality are inconclusive. The aim of this research project was to address these specific areas of uncertainty. Critically injured patients (n=135) were retrospectively investigated for the incidence and nature of adverse cardiac events (ACEs), and lev

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4

Indja, Ben. "Subclinical brain injury after cardiac surgery." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24086.

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Brain injury continues to be one of the most feared complications following cardiac procedures. While clinically overt cerebrovascular accidents are extremely well characterised and relatively rare under optimised conditions, at the other end of the spectrum, subclinical brain injury – which consists of post-operative cognitive dysfunction and silent brain infarcts (SBIs) – is poorly defined but of greater incidence. The lack of knowledge of subclinical brain injury is in large part due to lack of an objective means of measurement, meaning it is quantified using variable definitions and genera

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5

Caroll, Patricia A. "Markers of cardiac injury in ultraendurance runners." Thesis, University of Hawaii at Manoa, 2003. http://hdl.handle.net/10125/6969.

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6

Wasilewski, Melissa Anne. "ABSENCE OF V1AR ALTERS CARDIAC FUNCTION AT BASELINE AND FOLLOWING ACUTE CARDIAC INJURY." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/525634.

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Biomedical Sciences<br>Ph.D.<br>Heart failure (HF) is a prevalent disease affecting over 5.1 million people in the United States and over 23 million people worldwide. Many of the symptoms associated with HF are associated with neurohormonal responses to the decrease in cardiac output and systemic blood pressure, such as the activation of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system. Current treatment guidelines recommend using drugs that block β-adrenergic receptor (βAR) signaling (e.g. β- blockers) or RAAS signaling (e.g. angiotensin receptor blockers/ARB

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7

Maharsy, Wael. "Enhancing Cardiomyocyte Survival in Drug Induced Cardiac Injury." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23384.

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Cardiotoxicity associated with many cancer drugs is a critical issue facing physicians these days and a huge hurdle that must be overcome for a side effects-free cancer therapy. Survival of cardiac myocytes is compromised upon the exposure to certain chemotherapeutic drugs. Unfortunately, the mechanisms implicated in cardiac toxicity and the pathways governing myocyte survival are poorly understood. The following thesis addresses the mechanisms underlying the cardiotoxicity of two anticancer drugs, doxorubicin (DOX) and Imatinib mesylate (Gleevec). Transcription factor GATA-4, has recently eme

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8

Patel, Nikil. "Causes of brain injury associated with cardiac interventions." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/33073.

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Background& Objective: Brain injury after cardiac surgery is a serious concern for patients and their families. Thousands of air bubbles enter the cerebral circulation during cardiac surgery, but whether these are harmful to the brain and impact adversely on cognition remains subject of speculation. The purpose of this study was to use MRI to characterise new and pre-existing cerebral ischaemic lesions in patients undergoing cardiac surgery, and to test whether the accumulation of new lesions adversely affects cognition. This study also draws upon recent advances in intra-operative bubble sizi

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9

Naganathar, Sriveena. "Trauma induced secondary cardiac injury clinical manifestations and underlying mechanisms." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/54467.

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Since 1933, studies have explored the concept of trauma induced secondary cardiac injury (TISCI), yet till 2012, it had not been defined as the incidence of cardiac events and rise in cardiac biomarkers following traumatic injury. Despite, improvements in early outcomes, trauma patients have reduced long-term mortality with cardiac disease being the major contributor. Although many putative mechanisms have been suggested for TISCI, the underpinning pathophysiology still remains unclear. In this thesis, a prospective study of 290 critically injured patients identifies a 13% incidence of adverse

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10

Hiraumi, Yoshimi. "Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury." Kyoto University, 2009. http://hdl.handle.net/2433/126456.

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11

Khan, Areeg Ismail Ahmed Abdulla. "Novel translational strategies to treat cardiac injury and dysfunction." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8445.

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There is ample evidence of the crucial role of PI3K/Akt dependent signalling in cardiac function, cellular growth and cell apoptosis. The PI3K/Akt pathway mediates cardioprotective effects in experimental models of cardiovascular disease. For example, activation of this pathway ameliorates the sepsis-induced cardiac dysfunction, whereas its activation in myocardial ischaemia/reperfusion (I/R) limits cardiac injury. This thesis investigates the role of two drugs, which activate the PI3K/Aktpathway, namely the haematopoietic cytokine erythropoietin and the anti-malarial drug artesunate, in a mou

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12

Coetzee, Ettienne. "Myocardial injury after non-cardiac surgery: A prevalence study." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29298.

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Background Worldwide, the number of patients suffering from surgical complications account for a significant burden on healthcare systems. Myocardial injury after non-cardiac surgery (MINS) is a new entity that has recently been identified as an independent risk factor associated with 30-day all-cause mortality. The risk of death increases approximately 10 fold following MINS in the perioperative period. Diagnosing myocardial injury in nonsurgical patients often relies on specific symptomatology and clinical findings combined with special investigations. However, in surgical patients, more t

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13

Reyes, Leila. "Involvement of inflammatory oxidants in cardiac ischaemia/reperfusion injury." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/19667.

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Oxidative stress is a major feature of cardiac ischaemia/reperfusion (I/R) injury, with strong evidence implicating infiltrating leukocytes, in particular neutrophils, as a major source of oxidants in the infarcted myocardium. Activated leukocytes release the peroxidase enzyme, myeloperoxidase (MPO), which can produce the oxidants hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN). Chapter 3 examines the differential cellular effect of (patho)-physiological levels of HOCl and HOCN in cardiomyocytes. Both HOCl and HOSCN induced cellular damage characteristic of cardiac I/R injury and hig

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14

Qureshi, Muhammad Saqib Hayat. "Endothelial homeostasis and post-cardiac surgery inflammatory organ injury." Thesis, University of Leicester, 2016. http://hdl.handle.net/2381/37617.

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This thesis evaluates three most important etiological factors for organ injury namely, intravenous fluid, cardiopulmonary bypass (CPB) and blood transfusion, and considers their effects on endothelial dysfunction. This thesis evaluates 1. The safety of current fluid therapy, 2. The effects of novel versus established volume expanders on endothelial function and Acute Kidney Injury (AKI), 3. The effect of Sildenafil on renal glycocalyx in post-CPB AKI and 4. The effect of standard and modified red cell transfusions on lung and kidney injury. Using a systematic assessment of randomised controll

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15

Yamada, Tetsu. "Impact of the cardiac arrest mode on cardiac death donor lungs." Kyoto University, 2015. http://hdl.handle.net/2433/200492.

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16

Mörtberg, Erik. "Assessment of the Cerebral Ischemic/Reperfusion Injury after Cardiac Arrest." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132681.

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The cerebral damage after cardiac arrest is thought to arise both from the ischemia during the cardiac arrest but also during reperfusion. It is the degree of cerebral damage which determines the outcome in patients. This thesis focuses on the cerebral damage after cardiac arrest. In two animal studies, positron emission tomography (PET) was used to measure cerebral blood flow, oxygen metabolism and oxygen extraction in the brain. After restoration of spontaneous circulation (ROSC) from five or ten minutes of cardiac arrest there was an immediate hyperperfusion, followed by a hypoperfusion whi

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17

Burton, James O. "The mechanisms and consequences of haemodialysis induced acute cardiac injury." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10662/.

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Patients on dialysis are subject to a hugely elevated risk of cardiovascular mortality. Incidence and prevalence of, and mortality and morbidity from heart failure is significantly higher in the haemodialysis population than the general population as a whole. This thesis describes research work focusing on the large scale haemodynamic changes that occur during haemodialysis and how they may negatively impact on the cardiovascular system. Our results show that the haemodynamic disturbances which occur during haemodialysis are capable of causing a reduction in myocardial blood flow sufficient in

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18

Wilson, Michelle. "The psychosocial outcome of anoxic brain injury following cardiac arrest." Thesis, University of Lincoln, 2012. http://eprints.lincoln.ac.uk/18966/.

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Aim of the study The psychosocial outcome of anoxic brain injury following cardiac arrest is a relatively under researched, but clinically important area. The aim of the current study was to add to the limited existing literature exploring the psychosocial outcome for cardiac arrest survivors, but specifically explore if there is a greater impact on psychosocial outcome in individuals experiencing anoxic brain injury as a result. Methods A range of self report measures were used to compare the quality of life, social functioning and symptoms of anxiety, depression and post traumatic stress of

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19

Duan, Qiming. "Cardiac Na/K-ATPase in Ischemia-Reperfusion Injury and Cardioprotection." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1388151402.

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20

Sakai, Tetsuro. "Autologous heart cell transplantation improves cardiac function after myocardlal injury." Kyoto University, 2001. http://hdl.handle.net/2433/150591.

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21

Limchaiyawat, Pauline Tessalee. "The role of Chromogranin A in cardiac ischemic reperfusion injury." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1457303.

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Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed November 6, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 46-50).

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22

O'Brien, Nicole Wadsworth. "Cardiac ischemia reperfusion injury and the role of neutral sphingomyelinase /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3077801.

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23

MAGLIOCCA, AURORA. "Improving Outcome of Cardiac Arrest: from Cardiopulmonary Resuscitation Interventions to Post Resuscitation Care." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/304802.

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The present thesis focuses on different strategies targeting the two main aspects of cardiac arrest (CA) treatment, namely: cardiopulmonary resuscitation interventions and post-resuscitation care. It includes both experimental and translational studies directed to improve hemodynamic support during CPR, to define pulmonary dysfunction related to CPR, and to improve post-resuscitation outcomes. 1. In this experimental study, we sought to investigate the hemodynamic support generated by a mechanical piston device or manual chest compression (CC) in a moving ambulance. The hypothesis on whether

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24

Reed, Grant William. "Associations Between Cardiac Troponin, Mechanism of Myocardial Injury, and Long-Term Mortality After Non-Cardiac Vascular Surgery." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491571890479287.

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25

Von, Oppell Ulrich O. "Myocardial protection during cardiac surgery." Thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/25887.

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26

Amaro, Emilie, Stephen Pophal, and Jozef Zoldos. "Vascular Reconstruction in a Neonate after Iatrogenic Injury during Cardiac Catheterization." LIPPINCOTT WILLIAMS & WILKINS, 2017. http://hdl.handle.net/10150/627070.

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As technology and interventional techniques continue to evolve, both the volume and complexity of cardiac catheterizations will increase, leading to a rise in the number of complications. One of the most morbid complications of cardiac catheterization is vascular injury. We report the case of a 31-day-old, 3.0-kg infant with hypoplastic left heart syndrome who experienced a left common iliac artery disruption during cardiac catheterization resulting in a retroperitoneal hemorrhage. The extent of the vascular injury combined with the vessel caliber posed a technically challenging surgical scena

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27

Castellan, Raphaël Fabrice Paul. "Macrophage-derived WNTs in normal cardiac growth and regeneration following injury." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28808.

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Unlike other regenerative organs such as the liver, the adult mammalian heart does not regenerate tissue lost following injury such as myocardial infarction (MI). Instead a non-contractile fibrous scar develops that in the longer term leads to the development of heart failure (HF). In contrast to the adult, neonatal mammals, including mice and man, retain potent cardiac regenerative capacities and can replace myocardium lost following injury. Understanding the mechanisms underlying scar free repair in the neonate may help in development of new approaches to reduce the impact of myocardial inju

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28

Champattanachai, Voraratt. "Effects of hexosamine biosynthesis on an in vitro model of cardiac ischemia." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/champattanachai.pdf.

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29

McCracken, Laura A. "Cardiac function and physical activity participation in individuals with spinal cord injury." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61357.

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Individuals with spinal cord injury (SCI) are at greatly increased risk of cardiovascular disease (CVD). This is likely due to physical inactivity and impaired sympathetic control of the heart and blood vessels, resulting in cardiovascular dysfunction. Cardiovascular dysfunction in individuals with SCI is associated with injury level, whereby individuals with higher lesions exhibit greater dysfunction. In people without SCI, cardiac dysfunction predicts CVD. The studies that have investigated cardiac indices in individuals with SCI tend to agree that cardiac atrophy and impaired systolic funct

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30

Lucien, Jamie George. "The necrotic and apoptotic injury of cardiac xenotransplants caused by human serum." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58625.pdf.

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31

Hobbs, Daniel. "PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/106.

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Phosphodiesterase Type 5 (PDE5) inhibitors are cardioprotective against ischemia/reperfusion (I/R) injury. However, it remains uncertain if I/R affects PDE5. We hypothesized that generation of reactive oxygen species (ROS) during I/R leads to upregulation of PDE5, which contributes to pathological changes following acute myocardial infarction (AMI). Adult male ICR mice were subjected to 30 minutes of in vivo or ex vivo I/R. To examine the role of ROS, a subset of hearts were perfused with 100 µM hydrogen peroxide (H2O2). Expression and activity of PDE5, pPDE5, and cGMP-dependent protein k

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32

Deye, Nicolas. "Cardiac Arrest-Induced Brain Injury : Diagnostic And Prognostic Values of Circulating Biomarkers." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC150.

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Le pronostic de l’arrêt cardiaque (AC) reste dramatique. Diagnostiquer sa cause rapidement et prédire précocement son pronostic ("pronostication") de manière fiable permettrait de mieux guider les traitements initiaux, en évitant de traiter futilement les patients avec faible probabilité d’évolution favorable ou à l’inverse de permettre d’intensifier le traitement de patients avec forte probabilité d’évolution favorable. Les biomarqueurs, dont l’utilité diagnostique et pronostique reste débattue, semblent actuellement insuffisamment sensibles et précis, surtout dans les 1ères heures après la r

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33

NAGATA, KOHZO, TOYOAKI MUROHARA, MASAAKI MIYACHI, et al. "Glucocorticoid-Induced Hypertension and Cardiac Injury: Effects of Mineralocorticoid and Glucocorticoid Receptor Antagonism." Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/17604.

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34

Southworth, Richard. "Tolerance of the immature myocardium to ischaemia-reperfusion injury : the importance of a favourable antioxidant/free radical balance." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286204.

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35

Hunter, Arwen Leigh. "The role of peri-transplant ischemia and reperfusion injury in cardiac allograft vasculopathy." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2503.

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Heart transplantation is often the only therapeutic option for patients with end stage heart disease. Allograft organs are in short supply. Thus, preserving the life of a grafted organ is extremely important. Cardiac allograft vasculopathy (CAV) is an expression of chronic rejection that accounts for the greatest loss of graft function in transplanted hearts. Peri-transplant ischemia/reperfusion (I/R)-injury occurs during transplantation when blood flow is stopped to remove the heart from the donor and then is reinstated upon implantation of the donor heart into the recipient. This oxidative i

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36

Ahmed, Ishtiaq M. "Studies on the role of inflammation and stem cells in cardiac ischaemic injury." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2177/.

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The regenerative capacity of human myocardium is unable to compensate adequately forth significant loss of heart muscle that occurs in acute myocardial infarction (Ml). However, recent studies indicate that the adult heart may contain populations of cells that have stem cell characteristics and which could have regenerative potential. In order to better examine the biology of such cells, this study developed a mouse model of MI that combined low mortality, reproducible infarct size and the opportunity for reperfusion studies. One potential barrier to the expression of regenerative capacity at

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Gallagher, Sean. "Reducing acute kidney injury in patients with chronic kidney disease undergoing cardiac surgery." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8669.

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Patients with chronic kidney disease (CKD) are a group with a markedly increased risk of adverse events following cardiac surgery. A particular problem for these patients is the development of post-operative acute kidney injury (AKI), which is associated with a significant increase in morbidity and mortality. Currently, there are no effective therapies proven to modify AKI in patients undergoing cardiac surgery. This thesis has three parts. The first describes an analysis of the Barts Health NHS Trust cardiac surgical dataset. Specifically, outcomes of patients with CKD and AKI were examined.

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Patel, Nishith N. "Novel renoprotective strategies for the prevention of acute kidney injury following cardiac surgery." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683689.

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Acute kidney injury (AKI) following cardiac surgelY is common, is associated with a 4-fold increased risk of in-hospital death, a doubling of healthcare costs and prolonged hospital stay. The aim of this thesis was to develop novel renoprotective strategies by systematically reviewing current preventative sh·ategies, developing a large animal model of post-cardiopulmonalY bypass (CPB) AKI and assessing the interaction of red blood cell (RBC) transfusion and CPB in the pathogenesis of AKI. This thesis has found that cUlTently there are no effective renoprotective strategies for the prevention o

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39

HOUSE, STACEY LYNN. "ROLE OF FIBROBLAST GROWTH FACTOR 2 IN CARDIAC ISCHEMIA-REPERFUSION INJURY AND HYPERTROPHY." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1132336027.

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40

Zhang, Hongyu. "INCREASING MYOCYTE CONTRACTILITY EXACERBATES CARDIAC INJURY AND PUMP DYSFUNCTION AND ABLATION OF PHOSPHORYLATION." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/90859.

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Physiology<br>Ph.D.<br>Myocardial infarction (MI) leads to heart failure (HF) and premature death. The respective roles of myocyte death and depressed myocyte contractility in the induction of HF after MI have not been clearly defined. Cardiac ryanodine receptor (RyR2) has been linked to cardiac arrhythmias and HF. It has been controversial that protein kinase A (PKA) hyperphosphorylation of the RyR2 at a single residue, Ser-2808 is a critical mediator of progressive cardiac dysfunction after MI. We developed two mouse models. In one model with beta2a (LTCC subunit) overexpression we could pre

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41

Befroy, Douglas Eugene. "Osmotic shock : modulation of contractile function, pHâ†i and ischaemic damage in the perfused guinea-pig heart." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326024.

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42

Ciucci, Giulio. "Engineered heart tissues to investigate the role of mechanical loading and injury in cardiomyocyte proliferation." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/312213.

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Myocardial infarction is one of the most severe acute pathologies of the cardiovascular system. The adult mammalian heart is indeed unable to regenerate most of the lost cardiomyocytes (CMs) after cardiac injury. The loss of cardiomyocytes and the myocardial scarring after myocardial infarction eventually compromise contractility of the remaining myocardium, leading to heart failure. Therefore, promoting heart regeneration is one of the most crucial therapeutic targets in cardiovascular medicine. The lack of regenerative response is due to the loss of proliferative capacity of adult CMs which

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Ciucci, Giulio. "Engineered heart tissues to investigate the role of mechanical loading and injury in cardiomyocyte proliferation." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/312213.

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Myocardial infarction is one of the most severe acute pathologies of the cardiovascular system. The adult mammalian heart is indeed unable to regenerate most of the lost cardiomyocytes (CMs) after cardiac injury. The loss of cardiomyocytes and the myocardial scarring after myocardial infarction eventually compromise contractility of the remaining myocardium, leading to heart failure. Therefore, promoting heart regeneration is one of the most crucial therapeutic targets in cardiovascular medicine. The lack of regenerative response is due to the loss of proliferative capacity of adult CMs which

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44

Angert, David W. "Repair of the Injured Adult Heart Involves Resident Cardiac Stem Cell Derived New Myocytes." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/125347.

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Physiology<br>Ph.D.<br>The ability of the adult heart to generate new myocytes after injury is not established. Our purpose was to determine if the adult heart has the capacity to generate new myocytes after injury, and to gain insight into their source. Cardiac injury was induced in the adult feline heart by infusing Isoproterenol (ISO) for 10 days with minipumps and then animals were allowed to recover for 7 or 28 days. Cardiac function was measured with echocardiography and proliferative cells were identified by nuclear incorporation of 5-bromodeoxyuridine (BrdU; 7 day minipump infusion). B

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45

Speakman, Elisabeth Anne. "The fall in cardiac output after a scald burn injury to the anaesthetised rat." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328547.

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Husarchuk, A. G. "Peculiarities of cardiac injury in patients with ischemic heart disease on rheumatoid arthritis background." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18050.

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47

Prakash, Meeta B. "Deletion of Cardiac miR-17-92 Cluster Increases Ischemia/ Reperfusion Injury via PTEN Upregulation." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4956.

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The miR-17- 92 cluster is necessary for cell proliferation and development of the cardiovascular system. Deletion of this cluster leads to death in neonatal mice. The role of this cluster still needs to be defined following ischemia and reperfusion. Methods and Results: Adult male mice were injected with Tamoxifen- was to induce inducible cardiac-specific miR-17- 92-deficient (miR-17- 92-def: MCM:TG:miR-17- 92 flox/flox ) and wild type (WT: MCM:NTG:miR-17-92 flox/flox ) mice were subjected to 30 minutes of myocardial ischemia via left anterior descending coronary artery ligation followed by re

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48

CANALI, MARIA ELENA. "THE ROLE OF SIALIDASE NEU3 IN THE CARDIAC RESPONSE TO ISCHEMIA AND REPERFUSION INJURY." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/690293.

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THE ROLE OF SIALIDASE NEU3 IN THE CARDIAC RESPONSE TO ISCHEMIA AND REPERFUSION INJURY Maria Elena Canalia,b, Marco Piccolia, Andrea Ghiroldia, Federica Cirilloa, and Luigi Anastasiaa,b a Laboratorio delle cellule staminali e ingegneria tissutale, IRCCS Policlinico San Donato, piazza Malan 2, 20097 San Donato Milanese, Milano, Italia; email: maria.canali@unimi.it b Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, via Luigi Mangiagalli 31, 20133, Milano, Italia; L'infarto miocardico acuto (AMI) è una delle cause più comuni di morte in tutto il mondo. Le strateg

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Gates, Phillip Ellis. "Echocardiographic determination of left ventricular adaptation to upper body exercise." Thesis, Manchester Metropolitan University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312114.

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Varga, Anita. "Use of Cardiac Troponin I for Early Detection of Myocardial Damage in Dairy Cows." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229644005.

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