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1

Z, Bierman Fredrick, and Sanders Stephen P, eds. Echocardiographic diagnosis of cardiac malformations. Little, Brown, 1986.

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2

Rankin, Lorna. Tracheoesophageal Fistula Repair. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0053.

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Tracheoesophageal fistula (TEF) and esophageal atresia (EA) is a congenital malformation occurring in 1:3,000 to 4,500 births. The condition presents specific challenges to the anesthesiologist in the perioperative period. The presence of a fistula means that infants born with TEF/EA are at risk of aspiration and positive-pressure ventilation may be hazardous. These babies often have coexistent problems associated with prematurity and low birth weight, and 50% have associated abnormalities, most commonly congenital cardiac malformations.
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3

Bentham, James R. The genetics of congenital heart disease. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0022.

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Congenital heart disease (CHD) is defined as a structural cardiac malformation resulting from an abnormality of development; 8% of CHD is inherited in a Mendelian fashion and 12% results from chromosomal imbalance. Recurrence risk and new research suggest that even the remaining 80% of patients without an identifiable familial or syndromic basis for disease may have an identifiable genetic cause. The potential to understand these mechanisms is increasing with the advent of new sequencing techniques which have identified multiple or single rare variants and/or copy number variants clustering in
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4

Seipel, Catherine P., and Titilopemi A. O. Aina. Tracheoesophageal Fistula Repair. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0048.

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Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a congenital malformation occurring in approximately 1:4,000 live births. TEF/EA is characterized by disrupted continuity of the esophagus. There are five distinct types, but the most common is EA with a distal TEF. Most cases are diagnosed postnatally after an inability to pass a nasogastric tube (NGT), with subsequent radiographic imaging finding the NGT coiled within the esophageal pouch. The anesthetic management of TEF/EA repair can be complicated by the presence of cardiac, renal, and vertebral anomalies. Additionally, venti
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5

Kevin Luk, K. H., and Deepak Sharma. Subarachnoid Hemorrhage. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0024.

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Subarachnoid hemorrhage (SAH) is commonly caused by rupture of an intracranial aneurysm, arteriovenous malformation, or due to trauma. Prompt diagnosis and intervention are required to control intracranial pressure, maintain cerebral perfusion, and prevent rebleeding. Clinical grading of the bleed predicts morbidity and mortality, whereas imaging grading predicts risk of cerebral vasospasm. Hydrocephalus can occur as a result of SAH, which requires treatment with an external ventricular drain. Endovascular and open microsurgical procedures are available for securing the vascular abnormalities.
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6

Kastler, Bruno. MRI of Cardiovascular Malformations. Springer, 2014.

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7

Mri Of Cardiovascular Malformations. Springer, 2011.

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8

Kastler, Bruno. MRI of Cardiovascular Malformations. Springer, 2010.

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9

Thorne, Sara, and Paul Clift, eds. Functionally univentricular hearts and Fontan circulation. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199228188.003.0025.

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The functionally univentricular heart 172Staged approach to achieve definitive palliation 174Fontan circulation 176Hypoplastic left heart syndrome (HLHS) 186Rare and highly complex form of cyanotic congenital heart disease.The term describes a variety of cardiac malformations in which: • There is functionally a single ventricular cavity....
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10

D’Amato, Gaetano, Guillermo Luxán, and José Luis de la Pompa. Defining cardiac domains from the inside: NOTCH in endocardial–myocardial interactions. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0011.

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In this chapter we illustrate the signalling interactions of the endocardium with the other cardiac tissues to coordinate cardiac development. First, we describe the developmental origins of the endocardium. Then we focus on the Notch pathway because of its unique signalling activity in the endocardium, and briefly describe the elements of this signalling mechanism and the key cardiogenic processes that require endocardial Notch signalling: patterning of the early embryonic endocardium into prospective territories for valves and ventricular chambers, early valve formation, ventricular trabecul
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11

Kreeger, Renee Nierman, and James P. Spaeth. Tetralogy of Fallot. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0032.

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Patients with congenital heart disease are frequently encountered by the pediatric anesthesiologist for non-cardiac surgery. Fortunately, the majority of these patients have already undergone definitive repair of their cardiac lesions and can often be managed using traditional anesthetic methods. However, given the known association of congenital heart disease with other congenital malformations and syndromes, there is a relatively high likelihood that a pediatric anesthesiologist will encounter a situation involving a child with an unrepaired lesion. With the reported increased mortality rate
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12

Soleta, Amy, and Joelle Karlik. Goldenhar Syndrome. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0058.

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Goldenhar syndrome (also known as oculo-auriculo-vertebral spectrum, facio-auriculo-vertebral syndrome, and Goldenhar-Gorlin syndrome) is caused by fetal growth disturbances of the first two brachial clefts. Diagnostic criteria include eye, ear, mandibular, and/or vertebral anomalies. These patients may also have cardiac and renal malformations with varying degrees of severity. Airway management for Goldenhar patients may include difficult ventilation and intubation, which may become increasingly difficult with age. Vertebral anomalies including fused cervical vertebrae and/or cervical instabi
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13

Anderson, Robert H., Nigel A. Brown, Simon D. Bamforth, Bill Chaudhry, Deborah J. Henderson, and Timothy J. Mohun. Development of the outflow tract. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0023.

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The definitive cardiac outflow tracts have three components: the intra-pericardial arterial trunks, the arterial roots, and the ventricular outflow tracts. Improved correlations between normal development and cardiac malformations can be obtained by analysing the developing outflow tract in tripartite fashion with proximal, intermediate, and distal components. When first seen, the walls of the entire outflow tract express myocardial markers. With ongoing development, the distal border regresses away from the edges of the pericardial cavity. Subsequently, the distal outflow tract becomes the in
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14

Grunert, Marcel, Andreas Perrot, and Silke Rickert-Sperling. Complex network interactions: cardiovascular systems biology. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0033.

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A large quantity of molecular information on heart development, function, and disease has been generated over recent decades. However, most recent studies have been dominated by reductionistic approaches, and thus many aspects remain unclear, particularly regarding the primary causes of complex cardiovascular diseases such as congenital heart malformations. With the advent of high-throughput technologies, systems-based approaches have developed rapidly in biology and medicine. In the biology of cardiovascular systems complex data within or across different molecular levels of biological system
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15

Wenzel, Amy, and Deborah Kim. Psychopharmacology in Pregnancy and the Postpartum Period. Edited by Amy Wenzel. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199778072.013.21.

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A substantial minority of pregnant and lactating women meet criteria for one or more mental health disorders and, in many of these cases, treatment with psychotropic medication is indicated. Data from empirical studies on psychopharmacology using antidepressant medications for perinatal women suggest that the risk-benefit ratio is favorable, although their usage during pregnancy is associated with a slight increase in risk of spontaneous abortion, cardiac malformations (specifically with paroxetine), preterm birth, and poor neonatal adaptation syndrome. However, these risks should be contraste
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