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Journal articles on the topic 'Cardiomyopathy, GLS'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Stronati, Giulia, Lucia Manfredi, Alessia Ferrarini, et al. "Subclinical progression of systemic sclerosis-related cardiomyopathy." European Journal of Preventive Cardiology 27, no. 17 (2020): 1876–86. http://dx.doi.org/10.1177/2047487320916591.

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Aims Cardiac involvement in patients with systemic sclerosis (SSc) is frequent and represents a negative prognostic factor. Recent studies have described subclinical heart involvement of both the right ventricle (RV) and left ventricle (LV) via speckle-tracking-derived global longitudinal strain (GLS). It is currently unknown if SSc-related cardiomyopathy progresses through time. Our aim was to assess the progression of subclinical cardiac involvement in patients with SSc via speckle-tracking-derived GLS. Methods This was a prospective longitudinal study enrolling 72 consecutive patients with

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Bottinor, Wendy, Justin Godown, Gary Coburn, Jonathan Soslow, and Scott C. Borinstein. "Implementing strain imaging to identify early childhood cancer survivors at risk for cardiovascular disease." Journal of Clinical Oncology 37, no. 15_suppl (2019): e23070-e23070. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e23070.

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e23070 Background: In patients receiving active chemotherapy, myocardial strain has prognostic utility for risk of subsequent cardiomyopathy. We hypothesized a decrement in strain in early off-treatment childhood cancer survivors (CCS) is prognostic for developing cardiomyopathy. Methods: Retrospective analysis was performed in 22 CCS. Global longitudinal strain (GLS) and global circumferential strain (GCS) were assessed at baseline and on the first end-of-treatment study with adequate imaging quality. Parametric methods assessed the association between changes in GLS/GCS and cardiovascular ou

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Jenkinson, Mark, Dominic Meek, Sandy MacMillan, Rothwelle Tate, M. Helen Grant, and Susan Currie. "CARDIAC FUNCTION IS COMPROMISED IN PATIENTS WITH ELEVATED BLOOD COBALT LEVELS SECONDARY TO METAL-ON-METAL HIP IMPLANTS." Orthopaedic Proceedings 105-B, SUPP_11 (2023): 9. http://dx.doi.org/10.1302/1358-992x.2023.11.009.

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Elevated blood cobalt secondary to metal-on-metal (MoM) hip arthroplasties has been shown to be a risk factor for developing cardiovascular complications including cardiomyopathy. Published case reports document cardiomyopathy in patients with blood cobalt levels as low as 13µg/l (13ppb, 221nmol/l). Clinical studies have found conflicting evidence of cobalt-induced cardiomyopathy in patients with MoM hips. Global longitudinal strain (GLS) is an echocardiography measurement known to be more sensitive than ejection fraction at diagnosing early cardiomyopathies. The extent of cardiovascular injur

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Dimitroglou, Yannis, Constantina Aggeli, Alexandra Alexopoulou, et al. "The Contemporary Role of Speckle Tracking Echocardiography in Cirrhotic Cardiomyopathy." Life 14, no. 2 (2024): 179. http://dx.doi.org/10.3390/life14020179.

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Cirrhotic cardiomyopathy (CCM) is characterized by elevated cardiac output at rest, an inability to further increase contractility under stress, and diastolic dysfunction. The diagnosis of CCM is crucial as it can lead to complications during liver transplantation. However, its recognition poses challenges with conventional echocardiography techniques. Speckle tracking echocardiography (STE), particularly global longitudinal strain (GLS), is a novel index that enhances the diagnostic efficacy of echocardiography for both ischemic and non-ischemic cardiomyopathies. GLS proves more sensitive in

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Meek, D., M. Jenkinson, S. Macmillan, R. Tate, H. Grant, and S. Currie. "CARDIAC FUNCTION IS COMPROMISED IN PATIENTS WITH ELEVATED BLOOD COBALT LEVELS SECONDARY TO METAL-ON-METAL HIP IMPLANTS." Orthopaedic Proceedings 105-B, SUPP_12 (2023): 31. http://dx.doi.org/10.1302/1358-992x.2023.12.031.

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Elevated blood cobalt secondary to metal-on-metal (MoM) hip arthroplasties has been shown to be a risk factor for developing cardiovascular complications including cardiomyopathy. Published case reports document cardiomyopathy in patients with blood cobalt levels as low as 13µg/l. Clinical studies have found conflicting evidence of cobalt-induced cardiomyopathy in patients with MoM hips. The extent of cardiovascular injury, measured by global longitudinal strain (GLS), in patients with elevated blood cobalt levels has not previously been examined.Sixteen patients with prospectively collected b

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Pramod and Aishwerya. "Echocardiographic Predictors of Ventricular Arrhythmias in Patients with Non-Ischemic Cardiomyopathy: An Observational Study." International Journal of Current Pharmaceutical Review and Research 15, no. 12 (2023): 436–42. https://doi.org/10.5281/zenodo.11520464.

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AbstractAim: The aim of the present study was to assess the echocardiographic predictors of ventricular arrhythmias inpatients with non-ischemic cardiomyopathy.Methods: In this prospective, observational, multicenter, follow up study the study was conducted atDepartment of Cardiology. we consecutively included patients admitted with first time diagnosis of heart failureand LVEF <40%. We screened 200 patients in the study. The study patients were included in the heart failuresubgroup of the study.Results: There were 25% females as compared to males in the study. 16% had primary prevention an

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Toader, Despina-Manuela, Alina Paraschiv, Georgică Târtea, et al. "Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy." Biomedicines 13, no. 1 (2024): 11. https://doi.org/10.3390/biomedicines13010011.

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Background/Objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in patients with dilated cardiomyopathy admitted with heart failure decompensation. Methods: 97 patients with dilated cardiomyopathy and a left ventricle ejection fraction ≤ 40% were recruited, 51 with ischemic and 46 with nonischemic etiologies. Conventional and two-dimensional speckle-tracking echocardiography (2D-STE) were conducted in dilated

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Małek, Łukasz A., Łukasz Mazurkiewicz, Mikołaj Marszałek, et al. "Deformation Parameters of the Heart in Endurance Athletes and in Patients with Dilated Cardiomyopathy—A Cardiac Magnetic Resonance Study." Diagnostics 11, no. 2 (2021): 374. http://dx.doi.org/10.3390/diagnostics11020374.

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A better understanding of the left ventricle (LV) and right ventricle (RV) functioning would help with the differentiation between athlete’s heart and dilated cardiomyopathy (DCM). We aimed to analyse deformation parameters in endurance athletes relative to patients with DCM using cardiac magnetic resonance feature tracking (CMR-FT). The study included males of a similar age: 22 ultramarathon runners, 22 patients with DCM and 21 sedentary healthy controls (41 ± 9 years). The analysed parameters were peak LV global longitudinal, circumferential and radial strains (GLS, GCS and GRS, respectively

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Seo, Jeong-Sook. "Chronological change of left ventricular global longitudinal strain in patients with maternally inherited diabetes and deafness: A case series." Medicine 103, no. 10 (2024): e37447. http://dx.doi.org/10.1097/md.0000000000037447.

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Rationale: Maternally inherited diabetes and deafness (MIDD) is a rare genetic disorder arising from mitochondrial DNA mutations, characterized by a combination of diabetes mellitus and sensorineural deafness. It is known that MIDD patients with cardiomyopathy have a poor prognosis, but there are no established guidelines for the diagnosis and follow-up of cardiomyopathy in MIDD patients. Patient concerns: Patient 1 was a 48-year-old woman who visited the hospital with cardiomegaly and had been taking oral hypoglycemic agents for 8 years. Patient 2 was a 21-year-old man, the son of patient 1,

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Golukhova, E. Z., S. A. Alexandrova, N. I. Bulaeva, D. V. Mrikaev, O. I. Gromova, and B. Sh Berdibekov. "Prognostic value of myocardial strain by magnetic resonance imaging in nonischemic dilated cardiomyopathy: a systematic review and meta-analysis." Kardiologiia 62, no. 10 (2022): 35–41. http://dx.doi.org/10.18087/cardio.2022.10.n2034.

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Aim This study was aimed at performing a systematic review and meta-analysis to investigate the prognostic role of left ventricular (LV) myocardial strain variables as determined by magnetic-resonance imaging in non-ischemic dilated cardiomyopathy.Material and methods A search was performed in PubMed (MEDLINE), Google Scholar, and EMBASE databases for studies on the prognostic role of LV myocardial strain based on MR feature-tracking in non-ischemic dilated cardiomyopathy. Uncorrected odds ratio (OR) values reported by the studies where similar evaluation criteria of myocardial strain were ava

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Golukhova, E. Z., N. I. Bulaeva, D. V. Mrikaev, S. A. Alexandrova, and B. Sh Berdibekov. "Prognostic value of left ventricular global longitudinal strain and mechanical dispersion by speckle tracking echocardiography in patients with ischemic and nonischemic cardiomyopathy: a systematic review and meta-analysis." Russian Journal of Cardiology 27, no. 3S (2022): 5034. http://dx.doi.org/10.15829/1560-4071-2022-5034.

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Aim. To conduct a systematic review and meta-analysis in order to evaluate the prognostic value of left ventricular global longitudinal strain (LV GLS) and LV mechanical dispersion (LVMD) in ischemic and nonischemic cardiomyopathy.Material and methods. We searched PubMed, Google Scholar and Embase for studies on the prognostic value of LV GLS and LVMD in ischemic and nonischemic cardiomyopathy. Hazard ratios (HR) from included studies were pooled for metaanalysis.Results. Twelve studies were selected from 314 publications for this systematic review and meta-analysis. In total, 2624 patients (m

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Tseluyko, Vira, Olena Butko, and Kostyantyn Kinoshenko. "Prognostic value of left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy." Actual problems of modern medicine, no. 10 (November 28, 2022): 39–49. http://dx.doi.org/10.26565/2617-409x-2022-10-05.

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ABSTRACT. Hypertrophic cardiomyopathy (HCM) is one of the widespread genetically determined diseases of the myocardium, which is accompanied by the development of diastolic and, subsequently, systolic dysfunction of the myocardium. The aim of our study was to evaluate the clinical and instrumental features of patients with hypertrophic cardiomyopathy with impaired left ventricular global longitudinal strain (GLS) and its prognostic value for the development of cardiovascular events in the Ukrainian population of patients with hypertrophic cardiomyopathy. Materials and methods. The data of 35 p

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Kažukauskienė, Ieva, Giedrė Balčiūnaitė, Vaida Baltrūnienė, et al. "Left ventricular global longitudinal strain predicts elevated cardiac pressures and poor clinical outcomes in patients with non-ischemic dilated cardiomyopathy." Cardiovascular Ultrasound 19, no. 1 (2021): 21. https://doi.org/10.1186/s12947-021-00254-1.

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<strong>Background: </strong>Risk stratification in patients with non-ischemic dilated cardiomyopathy (NI-DCM) is essential to treatment planning. Global longitudinal strain (GLS) predicts poor prognosis in various cardiac diseases, but it has not been evaluated in a cohort of exclusively NI-DCM. Although deformation parameters have been shown to reflect diastolic function, their association with other hemodynamic parameters needs further elucidation. We aimed to evaluate the association between GLS and E/GLS and invasive hemodynamic parameters and assess the prognostic value of GLS and E/GLS

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Park, Jiesuck, Yeonyee E. Yoon, Eun Ju Chun, et al. "Endocardial versus whole-myocardial tracking global longitudinal strain analysis in patients with hypertrophic cardiomyopathy: A preliminary comparative study." PLOS ONE 18, no. 7 (2023): e0288421. http://dx.doi.org/10.1371/journal.pone.0288421.

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Background and objectives We investigated whether the feasibility of left ventricular (LV) global longitudinal strain (GLS) in hypertrophic cardiomyopathy (HCM) varies according to the methodology (e.g. endocardial vs. whole myocardial tracking techniques). Methods We retrospectively analyzed 111 consecutive patients with HCM (median age, 58 years; male, 68.5%) who underwent both transthoracic echocardiography (TTE) and cardiac magnetic resonance imaging (apical 29.7%, septal 33.3%, and diffuse or mixed 37.0%). TTE-whole myocardial and TTE-endocardial GLS were measured and compared in terms of

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Keranov, Stanislav, Saskia Haen, Julia Vietheer, et al. "Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy." Diagnostics 11, no. 12 (2021): 2188. http://dx.doi.org/10.3390/diagnostics11122188.

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The main aim of this study was to assess the prognostic utility of TAPSE/PASP as an echocardiographic parameter of maladaptive RV remodeling in cardiomyopathy patients using cardiac magnetic resonance (CMR) imaging. Furthermore, we sought to compare TAPSE/PASP to TAPSE. The association of the echocardiographic parameters TAPSE/PASP and TAPSE with CMR parameters of RV and LV remodeling was evaluated in 111 patients with ischemic and non-ischemic cardiomyopathy and cut-off values for maladaptive RV remodeling were defined. In a second step, the prognostic value of TAPSE/PASP and its cut-off valu

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Trivedi, Siddharth J., Timothy Campbell, Luke D. Stefani, Liza Thomas, and Saurabh Kumar. "Strain by speckle tracking echocardiography correlates with electroanatomic scar location and burden in ischaemic cardiomyopathy." European Heart Journal - Cardiovascular Imaging 22, no. 8 (2021): 855–65. http://dx.doi.org/10.1093/ehjci/jeab021.

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Abstract Aims Ventricular tachycardia (VT) in ischaemic cardiomyopathy (ICM) originates from scar, identified as low-voltage areas with invasive high-density electroanatomic mapping (EAM). Abnormal myocardial deformation on speckle tracking strain echocardiography can non-invasively identify scar. We examined if regional and global longitudinal strain (GLS) can localize and quantify low-voltage scar identified with high-density EAM. Methods and results We recruited 60 patients, 40 ICM patients undergoing VT ablation and 20 patients undergoing ablation for other arrhythmias as controls. All pat

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Obaid, Najjat, Samir El Hadidy, Mahmoud El Badry, and Hassan Khaled. "The Outcome of Diabetic Patients with Cardiomyopathy in Critical Care Unit: Hospital and Short-Term Outcome in a Period of Six Months to One Year." Open Access Macedonian Journal of Medical Sciences 7, no. 17 (2019): 2796–801. http://dx.doi.org/10.3889/oamjms.2019.655.

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BACKGROUND: Diabetes mellitus (DM) is a major risk factor for heart failure (HF) and coronary artery disease (CAD). DM may cause structural changes involving the left ventricle (LV) systolic and diastolic function. AIM: To compare patients who have diabetes and ischemic cardiomyopathy (ICM) to those with diabetic cardiomyopathy (DMCMP) regarding LV systolic function, diastolic function, in hospital long term and short-term mortality. METHODS: Ninety diabetic patients with heart failure and left ventricular ejection fraction (LVEF) ≤ 35%, admitted to Critical Care Medicine departmen

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Huang, Taiyuan, Schurr Patrick, Louisa Katharina Mayer, et al. "Echocardiographic and Electrocardiographic Determinants of Atrial Cardiomyopathy Identify Patients with Atrial Fibrillation at Risk for Left Atrial Thrombogenesis." Journal of Clinical Medicine 11, no. 5 (2022): 1332. http://dx.doi.org/10.3390/jcm11051332.

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Objective: Atrial cardiomyopathy (ACM) is associated with development of AF, left atrial (LA) thrombogenesis, and stroke. Diagnosis of ACM is feasible using both echocardiographic LA strain imaging and measurement of the amplified p-wave duration (APWD) in digital 12-lead-ECG. We sought to determine the thresholds of LA global longitudinal strain (LA-GLS) and APWD that identify patients with AF at risk for LA appendage (LAA) thrombogenesis. Methods: One hundred and twenty-eight patients with a history of AF were included. Left atrial appendage maximal flow velocity (LAA-Vel, in TEE), LA-GLS (T

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Komissarova, S. M., O. V. Krasko, N. M. Rineyskaya, and A. A. Efimova. "Predictive value of global longitudinal strain and geometry of left ventricle in patients with noncompaction cardiomyopathy." Russian Journal of Cardiology 26, no. 11 (2021): 4622. http://dx.doi.org/10.15829/1560-4071-2021-4622.

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Aim. To assess the prognostic role of a decrease in longitudinal strain and an increase in the left ventricular sphericity index as predictors of NYHA class III heart failure (HF) progression, requiring hospitalization in a cohort of patients with noncompaction cardiomyopathy (NCM) in combination with dilated cardiomyopathy (DCM).Material and methods. We examined 90 patients with a combination of NCM and DCM aged 18 to 72 years (median age, 41 years; men — 73; women — 17), who, in addition to conventional echocardiographic and magnetic resonance imaging (MRI) characteristics, were studied for

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Ehrhardt, Matthew J., Qi Liu, Daniel A. Mulrooney, et al. "Improved Cardiomyopathy Risk Prediction Using Global Longitudinal Strain and N-Terminal-Pro-B-Type Natriuretic Peptide in Survivors of Childhood Cancer Exposed to Cardiotoxic Therapy." Journal of Clinical Oncology, January 11, 2024. http://dx.doi.org/10.1200/jco.23.01796.

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PURPOSE To leverage baseline global longitudinal strain (GLS) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) to identify childhood cancer survivors with a normal left ventricular ejection fraction (LVEF) at highest risk of future treatment-related cardiomyopathy. METHODS St Jude Lifetime Cohort participants ≥5 years from diagnosis, at increased risk for cardiomyopathy per the International Guideline Harmonization Group (IGHG), with an LVEF ≥50% on baseline echocardiography (n = 1,483) underwent measurement of GLS (n = 1,483) and NT-proBNP (n = 1,052; 71%). Multivariable Cox regressi

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Parashar, N., M. Sinha, S. Sharma, and S. Ramakrishnan. "Left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy." European Heart Journal 41, Supplement_2 (2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0729.

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Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is not an isolated RV disease. Left ventricular (LV) or biventricular involvement is being increasingly diagnosed in such patients. There is available research to show that the LV peak strain calculated from feature tracking (FT) cardiac MRI is impaired even before the impairment of function. If present, such involvement is an adverse prognostic marker. Purpose The aim of this study is to calculate LV involvement in patients with ARVC using FT cardiac MRI. Methods 27 patients of ARVC who underwent cardiac MRI with late

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da Nóbrega Borges, José Victor, Samira Leila, and Manuella Machado. "Abstract 4124677: Left ventricular function and myocardial longitudinal strain analysis in patients with Chagas disease: case series and systematic literature review." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4124677.

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Introduction: Chagas disease is a significant cause of tropical disease-related mortality. It presents in acute, indeterminate, and chronic phases, with chronic cardiomyopathy being the most severe form, leading to heart failure, arrhythmias, and sudden cardiac death. Conventional echocardiography often fails to detect early subclinical dysfunction, whereas Global longitudinal strain (GLS) may provide earlier detection of myocardial strain abnormalities. Left ventricular dysfunction is an independent predictor of mortality and GLS is an emerging modality that may aid early detection of cardiac

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Cavus, Ersin, Kai Muellerleile, Samuel Schellert, et al. "CMR feature tracking strain patterns and their association with circulating cardiac biomarkers in patients with hypertrophic cardiomyopathy." Clinical Research in Cardiology, March 29, 2021. http://dx.doi.org/10.1007/s00392-021-01848-5.

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Abstract Aims CMR feature tracking strain (CMR-FT) provides prognostic information. However, there is a paucity of data in hypertrophic cardiomyopathy (HCM). We sought to analyze global CMR-FT parameters in all four cardiac chambers and to assess associations with NT-proBNP and cardiac troponin T (hsTnT) in patients with HCM. Methods This retrospective study included 144 HCM patients and 16 healthy controls with CMR at 1.5 T. Analyses were performed on standard steady-state free precession cine (SSFP) CMR data using a commercially available software. Global left ventricular (LV) strain was ass

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Toader, D. M., O. Neagoe, T. Scorbura, et al. "Mitral annulus excursion depression as the expression of left ventricle strain parameters damage in patients with dilated cardiomyopathy." European Heart Journal - Cardiovascular Imaging 24, Supplement_1 (2023). http://dx.doi.org/10.1093/ehjci/jead119.152.

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Abstract Funding Acknowledgements Type of funding sources: None. Background 4D echocardiography is a useful tool to identify both decreasing of mitral annular excursion (MAE) and left ventricle (LV) strain damage in patients with dilated cardiomyopathy (DCM). Our study aimed to identify a correlation between MAE decreasing and LV strain parameters in patients with DCM. Methods We enrolled 75 patients with DCM and 30 healthy volunteers. The evaluation consisted of clinical examination, laboratory tests, 12 leads electrocardiography. All participants underwent a complete transthoracic echocardio

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Aguiar Rosa, S., L. Branco, B. Thomas, et al. "Association between microvascular dysfunction and impaired myocardial deformation in hypertrophic cardiomyopathy." European Heart Journal - Cardiovascular Imaging 22, Supplement_1 (2021). http://dx.doi.org/10.1093/ehjci/jeaa356.388.

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Abstract Funding Acknowledgements Type of funding sources: None. Objective To analyze the relationship between coronary microvascular dysfunction (MCD) and left ventricular (LV) myocardial deformation in hypertrophic cardiomyopathy (HCM). Methods Prospectively inclusion of HCM patients (P). MCD was assessed by CMR, during regadenoson-induced hyperemia. For perfusion assessment, the myocardium was divided into 32 subsegments (16 AHA segments subdivided into an endocardial and epicardial layer). Ischemic burden was calculated as the number of involved subsegments, assigning 3% of myocardium to e

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Maia, Marcelo A., Ester Cerdeira Sabino, José Luiz Padilha da Silva, et al. "Abstract 15177: Speckle-Tracking Echocardiography Improves Risk Stratification in Patients With Chagas Cardiomyopathy." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.15177.

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Introduction: Chagas cardiomyopathy is an important cause of death in endemic areas. Speckle-tracking echocardiography (STE)-derived strain is a sensitive tool for evaluating myocardial function which may be helpful to improve risk stratification of Chagas cardiomyopathy patients. This study evaluated whether STE has incremental value for prognosis over traditional clinical and echocardiographic parameters in patients with Chagas cardiomyopathy. Methods: Patients with Chagas disease who had evidence of heart failure were selected for the study. Clinical evaluation, electrocardiogram (ECG), and

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Tian, Di, JingYu Zhang, YiFan He, et al. "Predictive value of left atrial strain analysis in adverse clinical events in patients with hypertrophic cardiomyopathy: a CMR study." BMC Cardiovascular Disorders 23, no. 1 (2023). http://dx.doi.org/10.1186/s12872-023-03069-2.

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Abstract Background A subset of patients with hypertrophic cardiomyopathy (HCM) will experience adverse clinical events such as heart failure (HF), cardiovascular death, and new-onset atrial fibrillation (AF). Current risk stratification methods are imperfect and limit the identification of patients at high risk for HCM. This study aimed to evaluate the role of cardiac magnetic resonance (CMR)-derived left atrial strain parameters in the occurrence of adverse clinical events in patients with HCM. Methods Left atrial (LA) structural, functional, and strain parameters were evaluated in 99 patien

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Peng, Xin, Huaibi Huo, Jin Gao, Xu Jiang, and Yuli Yuan. "Glycemic Influences on Hypertrophic Cardiomyopathy Myocardium: Insights From Cardiac MRI Feature Tracking." Journal of Magnetic Resonance Imaging, July 2, 2025. https://doi.org/10.1002/jmri.70031.

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ABSTRACTBackgroundHypertrophic cardiomyopathy (HCM) is a genetic disorder associated with left ventricular hypertrophy and elevated cardiovascular risk. Emerging evidence suggests glycemic disturbances may exacerbate myocardial injury.PurposeTo evaluate the effects of prediabetes and diabetes on myocardium in patients with HCM using cardiac MRI feature tracking (FT).Study TypeRetrospective.PopulationOne hundred thirty five participants (age: 58 ± 10 years; 60% male), divided into four subgroups according to the left ventricular maximal wall thickness (LVMWT) and hemoglobin A1c (HbA1c) level: 3

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Patsourakos, D., C. Aggeli, K. Gatzoulis, et al. "Left atrial deformation parameters among beta-thalassemia major patients." European Heart Journal 42, Supplement_1 (2021). http://dx.doi.org/10.1093/eurheartj/ehab724.011.

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Abstract Introduction Atrial cardiomyopathy is present in a significant proportion of beta thalassemia major (β-TM) patients, complicating their clinical condition. The diagnosis of atrial cardiomyopathy is challenging using conventional echocardiographic techniques. Purpose In our study we aimed to identify the presence of atrial cardiomyopathy by applying novel echocardiographic techniques in these patients. Methods 56 β-TM patients (mean age 39.3±9 years, 50% male sex) and 30, age and sex matched, healthy controls were examined by transthoracic echocardiography. Conventional echocardiograph

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Meucci, Maria Chiara, Rosa Lillo, Antonella Lombardo, et al. "Comparative analysis of right ventricular strain in Fabry cardiomyopathy and sarcomeric hypertrophic cardiomyopathy." European Heart Journal - Cardiovascular Imaging, July 28, 2022. http://dx.doi.org/10.1093/ehjci/jeac151.

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Abstract Aims To perform a comparative analysis of right ventricle (RV) myocardial mechanics, assessed by 2D speckle-tracking echocardiography (2D-STE), between patients with Fabry disease and patients with sarcomeric disease. Methods and results Patients with Fabry cardiomyopathy (FC) (n = 28) were compared with patients with sarcomeric hypertrophic cardiomyopathy (HCM), matched for degree of left ventricle hypertrophy (LVH) and demographic characteristics (n = 112). In addition, patients with Fabry disease and no LVH [phenotype-negative carriers of pathogenic α-galactosidase gene mutations (

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Barbosa, A. R., C. M. O'neill, C. Ruivo, et al. "P5270Impaired myocardial deformation assessed by cardiac magnetic resonance is associated with increased arrhythmic risk in hypertrophic cardiomyopathy." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz746.0241.

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Abstract Background Strain techniques, such as feature tracking cardiac magnetic resonance (FT-CMR), have emerged as a promise for more accurate evaluation of cardiac function compared to ejection fraction. In hypertrophic cardiomyopathy (HCM) patients, impaired myocardial deformation measured by FT-CMR has been associated with severity of hypertrophy and presence of late gadolinium enhancement (LGE) but associations with clinical severity and prognosis are scarce. Purpose To analyse the association between left ventricular strain measured by FT-CMR, morphologic features and prognostic markers

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Brusamolino, M., G. Casas, D. Miccoli, et al. "CMR-derived left atrial strain predicts adverse events in dilated cardiomyopathy." European Heart Journal - Cardiovascular Imaging 26, Supplement_1 (2025). https://doi.org/10.1093/ehjci/jeae333.493.

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Abstract Background Dilated cardiomyopathy (DCM) is associated with an increased risk of major adverse cardiovascular events (MACE). However, current risk stratification methods are imperfect. Left atrial global longitudinal strain (LA GLS) is an increasingly acknowledged predictive parameter, yet its potential role in DCM is not well defined. Purpose This study aims to investigate the prognostic role of cardiac magnetic resonance (CMR)-derived LA GLS for the occurrence of MACE in patients with DCM. Methods A retrospective, longitudinal, single-centre CMR study of DCM patients was conducted. D

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Devera, Justin L., Choo P. Wee, and Jina Sohn. "Strain imaging as a prognostic indicator for complications in COVID-19 patients." International Journal of Cardiovascular Imaging, July 16, 2024. http://dx.doi.org/10.1007/s10554-024-03170-3.

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AbstractThe goal of this study was to determine the potential for right ventricular (RV) and left ventricular (LV) strain to predict cardiopulmonary complications of COVID-19. We identified 276 patients with COVID-19 who underwent transthoracic echocardiography within 30 days of COVID-19 diagnosis at our institution. Patients were excluded if they had a history of any primary outcomes before COVID-19 diagnosis or insufficient imaging. LV global longitudinal strain (GLS) and RV GLS were obtained using 2-dimensional speckle-tracking echocardiography. Primary outcomes were death, pulmonary emboli

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Ker, J. "Walking in a straight line–the early detection of cardiomyopathy by the general physician." European Heart Journal 42, Supplement_1 (2021). http://dx.doi.org/10.1093/eurheartj/ehab724.0718.

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Abstract Introduction The orientation of muscle fibers in the left ventricle is sophisticated. This peculiar orientation causes the left ventricle to contract in three directions–longitudinal, radial and circumferential. Normal myocardial mechanics is essential for systolic and diastolic function. For the clinician an impairment in longitudinal function is of utmost importance, as it has been shown to be an early marker of left ventricular dysfunction, be that systolic or diastolic. Longitudinal function of the left ventricle can be quantified with tissue velocity imaging (TVI), mitral annular

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Desai, Milind Y., Yuichiro Okushi, Andrew Gaballa, et al. "Serial Changes in Ventricular Strain in Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Insights From the VALOR-HCM Trial." Circulation: Cardiovascular Imaging, September 2, 2024. http://dx.doi.org/10.1161/circimaging.124.017185.

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BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy, VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) demonstrated that mavacamten reduces the need for septal reduction therapy with sustained improvement in left ventricular (LV) outflow tract gradients and symptoms. Global longitudinal strain (GLS), a measure of regional myocardial function, is a more sensitive marker of systolic function. In VALOR-HCM, we assessed serial changes in LV and right ventr

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Bertini, Matteo, Arnold C.T. Ng, M. Louisa Antoni, et al. "Global Longitudinal Strain Predicts Long-Term Survival in Patients With Chronic Ischemic Cardiomyopathy." March 13, 2012. https://doi.org/10.1161/circimaging.111.970434.

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Background— Left ventricular (LV) global longitudinal strain (GLS) is a measure of the active shortening of the LV in the longitudinal direction, which can be assessed with speckle-tracking echocardiography. The aims of this evaluation were to validate the prognostic value of GLS as a new index of LV systolic function in a large cohort of patients with chronic ischemic cardiomyopathy and to determine the incremental value of GLS to predict long-term outcome over other strong and well-established prognostic factors. Methods and Results— A total of 1060 patients underwent baseline clinical evalu

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Pena, José Luiz Barros, Wander Costa Santos, Maria Helena Albernaz Siqueira, Isaac Hermes Sampaio, Isabel Cristina Gomes Moura, and Eduardo Back Sternick. "Glycogen storage cardiomyopathy (PRKAG2): diagnostic findings of standard and advanced echocardiography techniques." European Heart Journal - Cardiovascular Imaging, August 3, 2020. http://dx.doi.org/10.1093/ehjci/jeaa176.

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Abstract Aims Describe the findings obtained using standard echocardiography (Echo) and deformation indices (2D and 3D speckle tracking strain) in patients (Pts) with PRKAG2 cardiomyopathy. Seek to identify any peculiar characteristics and possible strain patterns that may distinguish this condition from other causes of left ventricular hypertrophy (LVH). Methods and results Thirty Pts with genetically proven PRKAG2 (R302Q and H401Q), 16 (53.3%) male, mean age 39.1± 15.4 years old, were examined using standard, speckle tracking (STE), and 3D Echo. Pacemaker (PM) had been implanted in 12 (40%)

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Faggiano, A., F. Gonzalez Santorun, C. Tomasino, et al. "Left atrial strain identifies low-risk hypertrophic cardiomyopathy patients: a CMR study." European Heart Journal - Cardiovascular Imaging 26, Supplement_1 (2025). https://doi.org/10.1093/ehjci/jeae333.202.

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Abstract Background Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of major adverse cardiovascular events (MACE), however, current risk stratification methods are imperfect. Left atrial global longitudinal strain (LA GLS) is an increasingly acknowledged predictive parameter, yet its potential role in HCM is not well defined. Purpose This study aims to investigate the prognostic role of cardiac magnetic resonance (CMR)-derived LA GLS for the occurrence of MACE in patients with HCM. Methods A retrospective, single-centre, CMR study of HCM patients was conducted. CMR image

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Triantafyllidi, H., D. Birba, I. Ikonomidis, et al. "P3552Estimating left ventricular myocardial deformation during cardiopulmonary exercise testing in patients with dilated cardiomyopathy and reduced ejection fraction." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz745.0415.

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Abstract Background Cardiopulmonary exercise testing (CPET) has been recognized as a valuable tool regarding the integrated estimation of exercise ability in patients with several cardiopulmonary diseases, dilated cardiomyopathy (DCM) included. Left ventricular (LV) abnormal myocardial deformation might be studied by newer echocardiography techniques. Aim of this study is to explore differences of LV myocardial deformation in DCM patients during a CPET session. Methods Forty-four DCM patients (mean age 53±13 years, 34 men) with an ejection fraction <50% (mean EF = 33±10%) and no history of

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Tomoaia, R., T. Anderton, I. Botis, et al. "Gender differences in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance feature tracking." European Journal of Preventive Cardiology 31, Supplement_1 (2024). http://dx.doi.org/10.1093/eurjpc/zwae175.445.

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Abstract Introduction The recognition of gender differences in cardiovascular disease is increasing. Cardiac magnetic resonance imaging (CMR) offers high spatial and temporal resolution images irrespective of body shape and size. This enables precise evaluation of deformational mechanics of cardiac contraction which can be impaired even when the ejection fraction is normal. While previous studies have suggested gender differences using echocardiography speckle-tracking in hypertrophic cardiomyopathy (HCM), there is no similar data on the use of CMR. The aim of the study was to compare cardiac

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Segura-Rodríguez, Diego, Francisco José Bermúdez-Jiménez, Lorena González-Camacho, et al. "Layer-Specific Global Longitudinal Strain Predicts Arrhythmic Risk in Arrhythmogenic Cardiomyopathy." Frontiers in Cardiovascular Medicine 8 (November 15, 2021). http://dx.doi.org/10.3389/fcvm.2021.748003.

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Background: Arrhythmogenic cardiomyopathy (AC) is a life-threatening disease which predispose to malignant arrhythmias and sudden cardiac death (SCD) in the early stages of the disease. Risk stratification relies on the electrical, genetic, and imaging data. Our study aimed to investigate how myocardial deformation parameters may identify the subjects at risk of known predictors of major ventricular arrhythmias.Methods: A cohort of 45 subjects with definite or borderline diagnosis of AC was characterized using the advanced transthoracic echocardiography (TTE) and cardiac magnetic resonance (CM

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Morioka, Mami, Seiji Takashio, Naoya Nakashima, et al. "Correlation Between Cardiac Images, Biomarkers, and Amyloid Load in Wild‐Type Transthyretin Amyloid Cardiomyopathy." Journal of the American Heart Association, June 14, 2022. http://dx.doi.org/10.1161/jaha.121.024717.

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Background Several imaging parameters and biomarkers provide diagnostic and prognostic information for wild‐type transthyretin amyloid cardiomyopathy. However, the relevance of these parameters and their association with cardiac amyloid load requires further substantiation. We aimed to elucidate the association of imaging parameters obtained using 99m Tc‐labeled pyrophosphate scintigraphy, cardiovascular magnetic resonance imaging, global longitudinal strain (GLS), and cardiac biomarkers with cardiac amyloid load in patients with wild‐type transthyretin amyloid cardiomyopathy. Methods and Resu

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Kinova, E., D. Somleva, N. Spasova, A. Borizanova, and A. Goudev. "P1353 Left ventricular performance patterns in patients with dilated cardiomyopathy and advanced heart failure." European Heart Journal - Cardiovascular Imaging 21, Supplement_1 (2020). http://dx.doi.org/10.1093/ehjci/jez319.788.

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Abstract Background Left ventricular (LV) global longitudinal strain (GLS) is a more sensitive parameter than ejection fraction in the assessment of LV function. It has been established as a predictor of cardiac death and adverse events. In patients with dilated cardiomyopathy (DCM) LV deformation and twist mechanics are reduced in varying degrees. Purpose The aim of the study was to determine different LV performance patterns in patients with DCM and advanced heart failure (HF). Methods In 52 patients with DCM with HF NYHA class III-IV (62 ± 13 years, 36 males) LV function had been assessed b

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pang, kunjing, Rong Wang, and lei song. "Abstract 4142540: Using Three-Dimensional Strain Deformation Imaging To Quantify Replacement Fibrosis In Hypertrophic Cardiomyopathy." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4142540.

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Background: Three-dimensional speckle tracking deformation STE (3D-STE) can overcome some limitations of 2D imaging. This study aims to verify the feasibility of using 3D-STE to quantify replacement fibrosis against enhanced cardiac magnetic resonance imaging (CMR-LGE). Method: 3D-STE and the extent of LGE (%LGE) were prospectively measured in a large cohort of HCM patients, with an interval ≦ of 72 hours. Results: 511 HCM patients (age 49.0 ± 14.3 years; 66.5% male) were enrolled. Three-dimensional global longitudinal strain (GLS-3D) moderately correlated with GLS-2D (r=0.622, p=0.000). GLS-3

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Mohamedhoesein, Sharida, Martijn Tukker, Emrah Kaya, and Kadir Caliskan. "Abstract 10980: Echocardiographic Evaluation of the Left Ventricular Function in Patients With Noncompaction Cardiomyopathy: Biplane Method, Wall Motion Score or Global Longitudinal Strain?" Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.10980.

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Introduction: Noncompaction cardiomyopathy (NCCM) is characterized by left ventricular (LV) hypertrabeculation. Therefore, endocardial tracing / quantification of LV function could be cumbersome. Hypothesis: Accurate assessment of the (subclinical) LV dysfunction in NCCM patients could improve non-invasive monitoring of disease progression, risk stratification, and treatment. Method: We reviewed the echocardiographic images of 67 patients (54% male, median age 48 year [22-73]. LV function was assessed by conventional biplane disk summation, wall motion score (WMS), and global longitudinal stra

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Mosgrove, Matthew J., Ritu Sachdeva, Kayla L. Stratton, et al. "Utility of apical four‐chamber longitudinal strain in the assessment of childhood cancer survivors: A multicenter study." Echocardiography 41, no. 2 (2024). http://dx.doi.org/10.1111/echo.15766.

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AbstractBackgroundA previous multicenter study showed that longitudinal changes in standard cardiac functional parameters were associated with the development of cardiomyopathy in childhood cancer survivors (CCS). Evaluation of the relationship between global longitudinal strain (GLS) changes and cardiomyopathy risk was limited, largely due to lack of quality apical 2‐ and 3‐chamber views in addition to 4‐chamber view. We sought to determine whether apical 4‐chamber longitudinal strain (A4LS) alone can serve as a suitable surrogate for GLS in this population.MethodsA4LS and GLS were measured i

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Onishi, Tetsuari, Kosuke Yoshii, Masato Tsuru, et al. "Abstract 19512: Right Ventricular Global Longitudinal Strain Improves Diagnostic and Prognostic Assessment in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy." Circulation 130, suppl_2 (2014). http://dx.doi.org/10.1161/circ.130.suppl_2.19512.

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Introduction: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable cardiomyopathy characterized by right ventricular (RV) myocardium dysfunction leading to RV failure and fatal arrhythmias. Hypothesis: RV global longitudinal strain (GLS) derived from two-dimensional speckle-tracking echocardiography (2DSTE) contributes to diagnostic and prognostic assessment in ARVC. Methods: We retrospectively evaluated the echocardiographic data of 67 patients referred with suspected ARVC and 27 age- and gender-matched healthy controls (Group C). Of 67 suspected ARVC patients, 34 patients (G

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Hirschberg, K., O. Paul, J. Salatzki, et al. "Contrast-agent free evaluation of cardiomyopathies with T1 mapping and the new fast strain-encoded (fSENC) magnetic resonance imaging." European Heart Journal 41, Supplement_2 (2020). http://dx.doi.org/10.1093/ehjci/ehaa946.0218.

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Abstract Background Cardiomyopathies (CMP) may cause impairment of cardiac function and structure. Cardiac Magnetic Resonance Imaging (CMR) is used for analysis and risk stratification of CMP by Late Gadolinium Enhancement (LGE). However, T1 mapping (T1) and fast strain encoded (f-SENC) sequences allow contrast-free and faster exams. The aim of this study was to characterize CMP by T1 and f-SENC to develop a faster and safer CMR protocol (fast-CMR). Methods CMP scans from our CMR database were retrospectively analyzed. All patients were scanned at 1.5T/3T scanner. Study groups were divided as

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Weise Valdés, Elena, Peter Barth, Misagh Piran, Kai Thorsten Laser, Wolfgang Burchert, and Hermann Körperich. "Left-Ventricular Reference Myocardial Strain Assessed by Cardiovascular Magnetic Resonance Feature Tracking and fSENC—Impact of Temporal Resolution and Cardiac Muscle Mass." Frontiers in Cardiovascular Medicine 8 (November 2, 2021). http://dx.doi.org/10.3389/fcvm.2021.764496.

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Aims: Cardiac strain parameters are increasingly measured to overcome shortcomings of ejection fraction. For broad clinical use, this study provides reference values for the two strain assessment methods feature tracking (FT) and fast strain-encoded (fSENC) cardiovascular magnetic resonance (CMR) imaging, including the child/adolescent group and systematically evaluates the influence of temporal resolution and muscle mass on strain.Methods and Results: Global longitudinal (GLS), circumferential (GCS), and radial (GRS) strain values in 181 participants (54% women, 11–70 years) without cardiac i

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Zhuang, Haiming, Kai Yang, Shihua Zhao, et al. "Incremental value of myocardial global longitudinal strain in predicting major adverse cardiac events among patients with hypertrophic cardiomyopathy." Echocardiography 41, no. 5 (2024). http://dx.doi.org/10.1111/echo.15834.

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AbstractObjectivesEndocardial global longitudinal strain (endo‐GLS) measured with echocardiography (echo) has been demonstrated to be associated with myocardial fibrosis (MF) and is a prognostic predictor in patients with hypertrophic cardiomyopathy (HCM). Late gadolinium enhancement cardiac magnetic resonance (LGE‐CMR) imaging showed that MF is primarily located in the myocardial layer of the extremely hypertrophic septal or ventricular wall. We hypothesized that GLS of the myocardial layer (myo‐GLS) is more strongly correlated with the extent of LGE (%LGE) and is a more powerful prognostic f

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