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Journal articles on the topic 'Cardiospermum halicacabum'

Author: Grafiati

Published: 10 December 2022

Last updated: 22 June 2025

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1

Respondek, U. "Cardiospermum halicacabum." Zeitschrift für Klassische Homöopathie 34, no. 04 (2007): 153–60. http://dx.doi.org/10.1055/s-2006-938377.

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2

Kudaravalli, Sreedevi 1. *. Jangala Venkateswara Rao 2. "EVALUATION OF ACUTE AND CHRONIC ANTI-INFLAMMATORY ACTIVITY IN ETHANOLIC EXTRACT OF AERIAL PARTS OF CARDIOSPERMUM HALICACABUM AND CARDIOSPERMUM CANESCENS IN ANIMAL MODELS." Journal of Scientific Research in Pharmacy 6, no. 12 (2017): 179–84. https://doi.org/10.5281/zenodo.1419589.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he present study investigates the zcute and chronic  anti-inflammatory activity in ethanolic extract of aerial parts of Cardiospermum halicacabum and Cardiospermum canescens  L using carrageenan, Acetic acid, Xylene , PMA induced edema in animals significantly swelling inhibited ***P<0.001 when compared to control group P<0.001when compared to test ethanolic extract dose 250mg, 500mgP<0.001 when compared to stabdard drug.And inchronic inflammatory  study revealed that treatment of rats with both the extracts of Cardiospermum halicacabum and Cardiospermum canescens (250 mg/kg and 500 mg/kg) showed significant (P<0.001) reduction in weight of cotton pellet induced granuloma, Formalin induced  edema in mice with 500 mg/kg of both extracts significantly (P<0.001) reduced paw thickness whereas 250 mg/kg of both extracts showed lesser effect (P<0.01) in reducing the paw volume.</em> <strong><em>KEYWORDS</em></strong><em>: Cardiospermum halicacabum and Cardiospermum canescens ethanolic extract, Indomethacin, Anti-inflammatory activity, Carrageenan, Indomethacin, Acetic acid, Xylene, PMA, Formalin, Cotton pellets.</em>

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3

Rani D, Jancy. "Phytochemical and Nutrient Composition of Fresh and Dried Cardiospermum Halicacabum Leaves." Food Science and Nutrition 10, no. 2 (2024): 1–7. http://dx.doi.org/10.24966/fsn-1076/100185.

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Cardiospermum halicacabum is a creeping herbaceous plant which propogates easily. Cardiospermum halicacabum L. belongs to family Sapindaceae. This plant is produced in the plains of Africa, America, Bangladesh, India and Pakistan. Its general names include: balloon vine, heart vine, heart pea, love-in-a-puff heart and Kanphuti. Its vernacular name (Tamil) is Mudakkathan.

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4

Babber, S., K. Mittal, R. Ahlawat, and T. M. Varghese. "Micropropagation of Cardiospermum Halicacabum." Biologia plantarum 44, no. 4 (2001): 603–6. http://dx.doi.org/10.1023/a:1013763208472.

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5

Bulama-Modu, M., T. K. Muftaudeen, A. E. Ayodele, and A. J. Akinloye. "Systematic wood anatomical study in some species of Sapindaceae Juss. in South-Western Nigeria." Plants and Environment 3, no. 2 (2021): 37–46. http://dx.doi.org/10.22271/2582-3744.2021.jun.37.

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Comparative wood anatomical studies was carried out on ten species in the family Sapindaceae. The species were relatively uniform in the features of their vessels, in which diffuse porous was observed with solitary vessels to pore multiples in transverse section and ray cells were predominantly heterogeneous in radial section. Fibres were long and extensive. The longest fibre was observed in Blighia sapida (1025±28.5 µm), while the shortest fibre was observed in Cardiospermum halicacabum (139±6.5 µm). The longest vessel was observed in Deinbolia pinnata (509±34.9 µm) and the shortest vessel was observed in Cardiospermum halicacabum (85.36±4.9 µm). The implication of these features in the taxonomy of the family was discussed. The Dendrogram based on the quantitative wood characters confirmed Allophylus africanus and Allophylus spicatus belong to the same genus as classified, likewise Blighia unijugata, Blighia sapida but Cardiospermum halicacabum is closely related to Paullinia pinnata while others exhibited distinct generic characters.

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6

Basker, Savitha, Vishnupriya V, and Surapaneni Krishnamohan. "CARDIOSPERMUM HALICACABUM LINN. - A REVIEW." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 23. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20261.

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Before the modern day, medicine and its pharmacopeia of synthetic drugs, there were plants and ancient civilizations knew how to use the plants strategically to treat common ailments and even life-threatening diseases. Natural plant-based remedies are used for the both acute and chronic health problems from treating common colds to control blood pressure and cholesterol. Plant medicines were the most widely used medicines in the world because of their safety and very less or no side effects. In this way, the aim of this review article was to summarize the phytochemical and medicinal information of the readily reachable plant Cardiospermum halicacabum Linn. This is commonly known as Balloon vine extensively dispersed in tropical and subtropical areas of world. The roots, leaves, stem, and seeds of this plant are employed as herbal medication. The phytochemical analysis confirmed that this herb contains flavonoids, terpenoids, tannins, saponin, protein, carbohydrates, glycosides, variety of fatty acids, and volatile esters. Due to the presence of various compounds, this plant has antibacterial, antifungal, antiparasitic, antidiarrheal, anxiolytic, antioxidant, antipyretic, antirheumatic, anticonvulsant, anti-inflammatory, and anticancinogenic activities.

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7

C.Jayanthi. "THE CARDIOSPERMUM HALICACABUM FEED UTILIZATION OF THE FRESHWATER FISH LABEO ROHITA." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 04, no. 12 (2018): 4987–92. https://doi.org/10.5281/zenodo.1401474.

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The present study focused the Cardiospermum Halicacabum plant have various medicine uses. This medicine plants helps to enhance immune power consume animals like aquatic animals and terrestrial animals especially our research focus Labeo rohita feed supplementary diet mixed with commercial feed Medicinal plants have been used in various traditional systems as they have immune potential against numerous diseases. In the present investigation, utilization of different feed on normal fish Labeo rohita have been studied for many hours. The feed utilization monitor various parameters growth, weight, reproduction well utilized various organs. Keywords: Environment, Cardiospermum Halicacabum, Labeo rohita, Parameters.

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8

Jacob, Bindu, Suresh Natarajan, Sagadevan Pattiyappan, Rathish Kumar Sivarman, and Syama M. Suresh. "Study on anticarcinogenic and apotoptic properties of methanolic stem extract of Cardiospremum halicacabum in MCF 7 cell line." Journal of Scientific and Innovative Research 4, no. 1 (2015): 43–48. http://dx.doi.org/10.31254/jsir.2015.4109.

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The present study reveals the medicinal properties of the present study reveals the medicinal properties of the Cardiospermum halicacabum. The Cytotoxic activity of methanolic stem extract of Cardiospermum halicacabum was tested against breast cancer cell line (MCF-7) using MTT assay. The Cytotoxic activity of methanolic stem extract of Cardiospermum halicacabum showed significant activity against tested cell line. The different concentrations (100, 500, 1000) was tested at an optical density of 540nm was observed to calculate the percentage of viability. Hundred percent viability was seen against control. The maximum inhibitory activity was seen in lower concentration (100%) at a optical density of 6.753 was observed. The minimum percentage of viability (50%) was observed at an optical density of 0.392 was observed in 1000 µg/ml). From the results it can be observed that the added compounds produced significant decrease in cell viability which confirms antiproliferative activity of the studied extracts. Acridine orange fluorescent staining, Neutral Red staining and Lactose dehydrogenase assays were carried out in MCF-7 breast cancer cell lines to study apoptopsis. The plant extract has shown significant apoptoptic activity against cancer cell lines.

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9

Ferrara, Lydia. "Cardiospermum halicacabum Linn.: Food and Drug." International Journal of Medical Reviews 5, no. 4 (2018): 146–50. http://dx.doi.org/10.29252/ijmr-050404.

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10

Brighenti, A. M., E. Voll, and D. L. P. Gazziero. "Biologia e manejo do Cardiospermum halicacabum." Planta Daninha 21, no. 2 (2003): 229–37. http://dx.doi.org/10.1590/s0100-83582003000200008.

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Estudos de biologia e manejo do balãozinho (Cardiospermum halicacabum) foram realizados na Embrapa Soja, Londrina-PR, através da condução de quatro experimentos em condições de campo e de casa de vegetação. O primeiro experimento teve o objetivo de avaliar o crescimento, o desenvolvimento e as exigências nutricionais das plantas de balãozinho. O segundo experimento foi conduzido em condições de campo, onde as sementes do balãozinho foram dispostas em várias profundidades, com o intuito de avaliar a capacidade de emergência das plantas. Dois outros experimentos foram conduzidos em casa de vegetação, a fim de avaliar a eficácia de herbicidas no controle dessa espécie. As maiores quantidades de matéria seca estão alocadas nos ramos, seguidos das folhas e das raízes. O balãozinho apresenta a seguinte seqüência decrescente de recrutamento de nutrientes: N, K, Ca, Mg, S e P. Há emergência de plantas de balãozinho em todas as profundidades de semeadura, desde a superfície do solo até 12 cm. Os tratamentos 2,4-D (1.005 g e.a. ha-1), paraquat (400 g i.a. ha¹), amônio-glufosinate (300 g i.a. ha-1), lactofen (144 g i.a. ha-1), carfentrazone-ethyl (12 g i.a. ha¹), sulfentrazone (600 g i.a. ha-1) e glyphosate (960 g i.a. ha-1) são eficazes no controle do balãozinho no estádio até quatro folhas.

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11

S., Nathiya, Senthil Kumar B., and Devi K. "Phytochemical Screening and GC MS Analysis of Cardiospermum halicacabum L. Leaf Extract." International Journal of Trend in Scientific Research and Development 2, no. 5 (2018): 512–16. https://doi.org/10.31142/ijtsrd15849.

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Plants have more vital sources of natural products and involving in the human health care system since the human civilization starting. Cardiospermum halicacabum L. is an Indian folklore medicinal plant and its family Sapindaceae. They have more potential in many biological activities with the presence of bioactive compounds. The aim of the present study was carried out by phytochemical screening and the GC MS analysis was proven leaf extract of Cardiospermum halicacabum L. was having important secondary metabolities are Alkaloids, Amino acids, Cardiac Glycosides, Flavonoids, Steriods, Terpenoids and Phenols are present in phytochemical screening and the 12 compounds are identified in GC MS studies Tricyclo 5.4.3.0 1,8 tetradecan 6 one, 4 ethenyl 33.50 and the lowest peak of compound is Aziridine, 2 1,1 dimethylethyl 3 methyl 0.10 and involving many biological activity, they are anti inflammatory, antineoplastic agent, Antigonistic, Antifungal, Antimicrobial, anthelmintic, Atitumor, protect cardiovascular diseases, Growth regulating activity, Anti ACHE in the treatment of Myasthenia Gravis, Antiarrhymthmic properties, Antihepatotoxic. Hence this study is revealed the bioactive compounds, and its molecular formula, weight, and biological activity. This study is May helpful for screening to develop new drugs with traditionaly in pharmaco service system. S. Nathiya | B. Senthil Kumar | K. Devi "Phytochemical Screening and GC-MS Analysis of Cardiospermum halicacabum L. Leaf Extract" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-5 , August 2018, URL: https://www.ijtsrd.com/papers/ijtsrd15849.pdf

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12

Grace, XFatima, S. Shanthi, D. Chamundeeswari, S. Latha, S. Seethalakshmi, and PK Manna. "Isolation and characterisation of Cardiospermum halicacabum mucilage." International Journal of Green Pharmacy 5, no. 4 (2011): 314. http://dx.doi.org/10.4103/0973-8258.94354.

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13

Sarvananda, L., D. Premarathne Amal, and C. Karunarathna Samantha. "Immunomodulatory Effect of Cardiospermum Halicacabum against Cancer." Biomedical Journal of Scientific & Technical Research 10, no. 4 (2018): 1–4. https://doi.org/10.26717/BJSTR.2018.10.001976.

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The immune system is known to be involved in the etiology as well as pathophysiological mechanisms of many diseases Traditional medicine gives emphasis on the promotion of health a concept of strengthening host defenses against different diseases. Rasayana plants are particularly recommended for the treatment of an immune disorder, Ayurveda may play an important role in modern health care, particularly where satisfactory treatment is not available. Development of agents, capable of moving a patient's immune systems from a state of immune deficiency to normal function, would be able to a significant impact on a patient's disease condition. Such an agent would not be a cure but would control the manifestation and course of the disease. Natural Products, especially from plants, have been used for the treatment of various diseases for thousands of years. Countries such as China, Egypt, India, Greece, and Sri Lanka have practiced the use of herbs as medicines from ancient times and an impressive number of modern drugs have been developed from them. Natural products serve as one source of structurally novel chemicals and are expected to be fruitful for investigation in medicine. Balloon vine plant (botanical name: <em>Cardiospermum Halicacabum)</em> has various pharmacological actions like antioxidant, anti-viral, anti-diabetic, anti-convulsing, anti-diarrheal, anticancer, fertility, anti-bacterial, anti-fungal, and etc. Due to the presence of constituents such as beta-sitosterol and its D-glucoside, an alkaloid, oxalic acid, amino acids, saponin, quebrachitol, erucic acid, oleic acid, eicosonic acid, octanoic acid, n-hexadecanoic acid and rich in tri-terpenoids, therefore these herbs could be valuable for the development of commercial drugs

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14

G, Savitha, Vishnupriya V, and Surapaneni Krishnamohan. "IN VITRO ANTIOXIDANT CAPACITY AND FREE RADICAL SCAVENGING ACTIVITIES OF CARDIOSPERMUM HALICACABUM LINN." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (2018): 421. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25044.

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Objective: Free radicals and oxidants are produced in the body during normal cellular metabolism and exposure to pollutions and ionizing radiations. They exert beneficial and harmful effects to the human body. Harmful effects of these radicals are destroyed by either antioxidants of our body in situ or antioxidants which are supplied through foods. Hence, the aim of this present study is to assess the antioxidant and free radical scavenging capacity of the easily available edible plant Cardiospermum halicacabum Linn. (Mudakathan keerai).Methods: Antioxidant and free radical scavenging activities of the aerial parts extract of C. halicacabum was determined by 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging assay, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assay, ferrous ion chelating assay, nitric oxide (NO) radical scavenging assay, superoxide radical scavenging assay, hydroxyl radical scavenging assay, and lipid peroxidation assay.Results: Remarkable free radical scavenging potential was observed in the ethanolic extract of C. halicacabum with IC50 values on all tested radicals, namely DPPH (IC50=34.06 μg/ml), ABTS (IC50=21.45 μg/ml), ferrous ion chelating (IC50=19.56 μg/ml), NO (IC50=25.16 μg/ml), superoxide (IC50=35.16 μg/ml), hydroxyl (IC50=28.56 μg/ml), and lipid peroxidation (IC50=33.12 μg/ml). The results revealed that ethanolic extract of C. halicacabum Linn. has significant antioxidant activity.Conclusion: The present study suggested that the aerial part extract of C. halicacabum serves as a good source of natural antioxidants.

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Kumari, C. Senthil, A. Kamatchi, K. Meghana, K. V. Mridhula, T. Kanimozhi, and S. Monisha. "Evaluation of In Vitro Anthelmintic Activity and Phytochemical Analysis of Ethanolic Extract of Cardiospermum halicacabum Leaves." International Journal of Current Research and Review 14, no. 19 (2022): 21–26. http://dx.doi.org/10.31782/ijcrr.2022.141904.

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Introduction: The infection caused by helminths is called as Helminthiasis. It is otherwise known as helminthosis, helminthiases, helminth, infection and worm infection. They often live in the gastrointestinal tract of their host, but they may also burrow into other organ, where they induce physiological damage. The different categories of worms consist of Roundworms, Pinworms, Threadworms, Whipworm Hookworm, Flatworms and Tapeworm. Objective: The present study was carried out to find the anthelmintic activity of Cardiospermum halicabum. Methods: The anthelmintic activity of Cardiospermum halicacabum was analyzed by in vitro method by using the Indian earthworms. The activity was performed and the paralysis time and death time were noted down. The anthelmintic activity of the extract was compared with that of the standard drug Albendazole. Results: The ethanolic extract at the concentrations of 100 mg/ml, 200 mg/ml, 300mg/ml showed paralysis and death time in 7, 6 and 36, 28 mins respectively. The effect increased with concentration. The extract caused paralysis followed by death of earthworms at all tested dose levels. Conclusion: The extract showed paralysis followed by death of worms at all tested dose levels. Based on the study the Ethanolic leaf extract of Cardiospermum halicacabum has potent anthelmintic activity.

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Gildenhuys, Enelge, Allan Ellis, Scott Carroll, and Roux Johannes Le. "The ecology, biogeography, history and future of two globally important weeds: Cardiospermum halicacabum Linn. and C. grandiflorum Sw." NeoBiota 19 (October 11, 2013): 45–65. https://doi.org/10.3897/neobiota.19.5279.

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Members of the balloon vine genus, Cardiospermum, have been extensively moved around the globe as medicinal and horticultural species, two of which are now widespread invasive species; C. grandiflorum and C. halicacabum. A third species, C. corindum, may also have significant invasion potential. However, in some regions the native status of these species is not clear, hampering management. For example, in South Africa it is unknown whether C. halicacabum and C. corindum are native, and this is a major constraint to on-going biological control programmes against invasive C. grandiflorum. We review the geography, biology and ecology of selected members of the genus with an emphasis on the two most widespread invaders, C. halicacabum and C. grandiflorum. Specifically, we use molecular data to reconstruct a phylogeny of the group in order to shed light on the native ranges of C. halicacabum and C. corindum in southern Africa. Phylogenetic analyses indicate that southern African accessions of these species are closely related to South American taxa indicating human-mediated introduction and/or natural long distance dispersal. Then, on a global scale we use species distribution modelling to predict potential suitable climate regions where these species are currently absent. Native range data were used to test the accuracy with which bioclimatic modelling can identify the known invasive ranges of these species. Results show that Cardiospermum species have potential to spread further in already invaded or introduced regions in Australia, Africa and Asia, underlining the importance of resolving taxonomic uncertainties for future management efforts. Bioclimatic modelling predicts Australia to have highly favourable environmental conditions for C. corindum and therefore vigilance against this species should be high. Species distribution modelling showed that native range data over fit predicted suitable ranges, and that factors other than climate influence establishment potential. This review opens the door to better understand the global biogeography of the genus Cardiospermum, with direct implications for management, while also highlighting gaps in current research.

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Meesil, Wipanee, Wudtichai Wisuitiprot, Jatuporn Ngoenkam, et al. "Antibacterial Activity of Ethanolic Extract of Cardiospermum halicacabum against Methicillin-Resistant Staphylococcus aureus." Trends in Sciences 22, no. 2 (2024): 8854. https://doi.org/10.48048/tis.2025.8854.

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We investigated the antibacterial activity of Cardiospermum halicacabum extract against methicillin-resistant Staphylococcus aureus (MRSA) via the disk diffusion method and identified the plant’s bioactive phytochemicals. Additionally, we evaluated the synergistic effects, and primary mechanism of action of the plant extract against the S. aureus strain PB57 (MRSA). The ethanolic extract of C. halicacabum contained beneficial secondary metabolites such as the flavonoids apigenin, terpenoids and tannins. The total phenolic content, expressed as the gallic acid equivalent (g GAE/kg), was 87.66 ± 14.56 g GAE/kg at a concentration of the 1 mg/mL. The plant extract inhibited and killed the S. aureus strain PB57 with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.98 mg/mL. Electron microscopy revealed that the plant extract caused damage to the ultrastructures of the cells of the pathogens. The compounds in the extract remained below known maximum acceptable cytotoxicity thresholds for fibroblast cells, which are typically in the range of [include specific value from relevant guidelines or literature]. Further cytotoxicity assays are required to determine the precise safety margins for therapeutic use. Although the extract showed promise against MRSA, its application as a broad treatment for infectious diseases requires more specific testing on other pathogens. Based on the scope of our research, C. halicacabum could be a viable candidate for the development of treatments targeting MRSA-related infections. HIGHLIGHTS Our investigation revealed that the ethanolic extract of Cardiospermum halicacabum exhibited significant antibacterial activity against the methicillin-resistant Staphylococcus aureus (MRSA) strain PB57. The extract contained beneficial secondary metabolites, including flavonoids such as apigenin, as well as terpenoids and tannins. Moreover, the electron microscope shown that the extract disrupted the pathogen’s cell structures and, despite showing some cytotoxicity at higher doses, remained within safe limits, positioning C. halicacabum as a potential treatment for infectious diseases. GRAPHICAL ABSTRACT

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18

Shekhawat, Mahipal S., M. Manokari, N. Kannan, J. Revathi, and R. Latha. "Synthesis of silver nanoparticles using Cardiospermum halicacabum L. leaf extract and their characterization." Journal of Phytopharmacology 2, no. 5 (2013): 15–20. http://dx.doi.org/10.31254/phyto.2013.2503.

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Present study reports the biogenesis of silver nanoparticles from the leaves of Cardiospermum halicacabum L. and their characterization. C. halicacabum has been used in traditional medicines but so far it has not been tested for synthesis of silver nanoparticles (AgNPs). The aqueous silver ions exposed to the herbal extract, which were reduced and the nanoparticles were synthesized. The presence of nanoparticles was confirmed by the formation of brown color of the reaction mixture. The brown color was observed after 25 minutes. The silver nanoparticules qualitatively characterized by UV-Visible spectrophotometer. A sharp peak was observed in between 422nm to 447nm indicates formation of silver nanoparticles.

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19

Ngoenkam, Jatuporn, Aussanee Nuiyen, Aunchalee Thanwisai, Pussadee Paensuwan, and Sutatip Pongcharoen. "Cardiospermum halicacabum Extract Inhibits the Production of Nitric Oxide and Reactive Oxygen Species in LPS-Stimulated RAW 264.7 Cells through Erk/p38 Signalling Pathways." Trends in Sciences 22, no. 1 (2024): 8690. http://dx.doi.org/10.48048/tis.2024.8690.

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The medicinal plant Cardiospermum halicacabum has been extensively studied for its potential in various therapeutic activities, including anti-inflammation, antioxidant, antibacterial, antifungal and antiparasitic effects. However, the specific molecular mechanisms responsible for its anti-inflammatory properties remain largely unknown. In order to shed light on this aspect, the current investigation was aimed at elucidating the underlying mechanisms through which C. halicacabum exerts its anti-inflammatory response. The different concentrations of C. halicacabum extract were tested for cytotoxicity on RAW264.6 murine macrophage cells by MTT assay. The inhibition of nitric oxide (NO) in LPS-induced cell pre-treated with the extract was evaluated by Griess assay using Griess reagent. Flow cytometry and fluorescent microscopy were used to examine the reactive oxygen species (ROS) in the treated cells. The expression of iNOS and the phosphorylation status of Erk1/2, p38 and NF-kB were determined by western blotting. The C. halicacabum extract at concentrations up to 125 µg/mL did not cause the cytotoxicity to the RAW264.6 murine macrophage cells. Incubation of LPS-induced cells with the extract significantly minimized the production of NO as compared with the LPS-stimulated cells. Further, the extract significantly reduced ROS generation in LPS-induced cells. In the present of C. halicacabum, LPS-treated cells had the reduced NOS expression as well as had low phosphorylation on Erk1/2, p38 and NF-kB. C. halicacabum attenuates NO and ROS production under the regulation of Erk1/2 and p38 pathway as well as NF-kB. HIGHLIGHTS The underlying mechanisms of halicacabum on its anti-inflammatory response were investigated. halicacabum extract significantly reduced ROS and NO generation in LPS-induced cells. halicacabum attenuates NO and ROS production under the regulation of Erk1/2 and p38 pathway as well as NF-kB. GRAPHICAL ABSTRACT

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20

Abitha, S., J. Prakash Maran, and J. Jony Blessing Manoj. "Functional properties of hot air dried Cardiospermum halicacabum leaves." Materials Today: Proceedings 45 (2021): 2887–89. http://dx.doi.org/10.1016/j.matpr.2020.11.882.

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21

Divya, l. S. "Antimicrobial, Anticancer Activities and DNA Fragmentation of Cardiospermum Halicacabum." International Journal for Research in Applied Science and Engineering Technology V, no. IX (2017): 1656–62. http://dx.doi.org/10.22214/ijraset.2017.9341.

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22

Dhayabaran, Daniel, Jeyaseeli Florance, Nandakumar Krsihnadas, Indumathi, and Muralidhar. "Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum." Revista Brasileira de Farmacognosia 22, no. 3 (2012): 323–29. http://dx.doi.org/10.1590/s0102-695x2012005000017.

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23

Zalke, AshishS, B. Duraiswamy, UpendraB Gandagule, and Nidhi Singh. "Pharmacognostical evaluation of Cardiospermum halicacabum Linn. leaf and stem." Ancient Science of Life 33, no. 1 (2013): 15. http://dx.doi.org/10.4103/0257-7941.134561.

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24

Hübner, G. "Cardiospermum halicacabum - Ein neues Mittel zur Behandlung der Konstitution." Allgemeine Homöopathische Zeitung 244, no. 06 (2007): 223–32. http://dx.doi.org/10.1055/s-2006-936702.

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25

Wickramaratne, YN, RMHKK Rajapaksha, RS Maddumage, SP Senanayake, ARN Silva, and HEH Perera. "Assessment of the in vitro anti-inflammatory effects of Cardiospermum halicacabum extract." Journal of Phytopharmacology 14, no. 2 (2025): 110–15. https://doi.org/10.31254/phyto.2025.14206.

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Background: Inflammation is the body’s natural response to harmful stimuli. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate inflammation, but they often come with significant side effects. Consequently, there is a growing need for new, effective anti-inflammatory agents with minimal adverse effects, preferably derived from plants. Aims and Objectives: This study aimed to prepare aqueous and ethanol extracts of the entire Cardiospermum halicacabum plant using the cold maceration extraction method, evaluate their in vitro anti-inflammatory properties, and determine the IC50 values through a concentration-response curve. Methodology: Whole C. halicacabum plants were collected, and extracts were prepared using cold maceration with ethanol and water. The anti-inflammatory properties of these extracts were assessed in vitro using the heat-induced ovalbumin denaturation method, with diclofenac sodium serving as the reference drug. Results: The ethanol and aqueous extracts yielded 15.7% and 10.4% w/w, respectively. Compared to diclofenac sodium (IC50 at 1922 μg/mL), the extracts demonstrated mild-to-moderate, concentration-dependent anti-inflammatory activity, with IC50 values of 5157 μg/mL for the ethanol extract and 8121 μg/mL for the aqueous extract. A statistically significant positive correlation was observed between the concentration and percentage inhibition of the extracts, with a p-value of less than 0.05 and an R-square value close to one. Conclusion: The extracts of C. halicacabum exhibit mild-to-moderate anti-inflammatory activity compared to standard diclofenac sodium.

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Merighi, Stefania, Alessia Travagli, Paola Tedeschi, Nicola Marchetti, and Stefania Gessi. "Antioxidant and Antiinflammatory Effects of Epilobium parviflorum, Melilotus officinalis and Cardiospermum halicacabum Plant Extracts in Macrophage and Microglial Cells." Cells 10, no. 10 (2021): 2691. http://dx.doi.org/10.3390/cells10102691.

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Background: We investigated the phenolic content characterizing different plant extracts from Epilobium parviflorum, Cardiospermum halicacabum, and Melilotus officinalis, their antioxidant, antiinflammatory effects, and their mechanism of action. Methods: plant samples were macerated in 40% ethanol or hot/ cold glycerate and assessed for polyphenols content. The antioxidant activity was investigated by DPPH radical scavenging assay and H2DCFDA test in LPS-stimulated RAW264.7 macrophages and N9 microglial cells. MTS experiments and antiinflammatory properties verified cellular toxicity through NO assay. Interaction with A2A adenosine receptors was evaluated through binding assays using [3H]ZM241385 radioligand. Results: Polyphenols were present in 40% ethanol plant extract, which at 0.1–10 µg/µL achieved good antioxidant effects, with a DPPH radical scavenging rate of about 90%. In LPS-stimulated cells, these plant extracts, at 1μg/μL, did not affect cell vitality, displayed significant inhibition of H2DCFDA and NO production, and inhibited ZM 241385 binding in CHO cells transfected with A2A receptors. RAW 264.7 and N9 cells presented a density of them quantified in 60 ± 9 and 45 ± 5 fmol/mg of protein, respectively. Conclusion: Epilobium parviflorum, Cardiospermum halicacabum, and Melilotus officinalis extracts may be considered a source of agents for treating disorders related to oxidative stress and inflammation.

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Foster, Jarryd D., Allan G. Ellis, Llewellyn C. Foxcroft, Scott P. Carroll, and Roux Johannes Le. "The potential evolutionary impact of invasive balloon vines on native soapberry bugs in South Africa." NeoBiota 49 (July 25, 2019): 19–35. https://doi.org/10.3897/neobiota.49.34245.

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Following their establishment in new communities, invasive species may cause evolutionary changes in resident native species. This is clearly true for phytophagous insects, which may adapt rapidly when utilising abundant and widespread introduced hosts. The balloon vines Cardiospermum halicacabum and C. grandiflorum were introduced to South Africa approximately 100 years ago and are classified as minor and major weeds, respectively. Here we assess the potential evolutionary impact of these vines on native Leptocoris soapberry bug populations in Kruger National Park (KNP), using phylogenetic and morphometric analyses. We found that soapberry bugs associated with C. halicacabum are genetically and morphologically distinct from those associated with C. grandiflorum. This suggests that native soapberry bugs in KNP exhibit some degree of host preference, indicating that these vines may have had significant evolutionary consequences for these insects. The proboscis length of soapberry bugs feeding on C. halicacabum closely matched fruit size, often being longer than fruit size at the population level. These soapberry bugs are therefore well-suited to feeding on this introduced plant species.

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Nathiya, S., B. Senthil Kumar, and K. Devi. "Phytochemical Screening and GC-MS Analysis of Cardiospermum halicacabum L. Leaf Extract." International Journal of Trend in Scientific Research and Development Volume-2, Issue-5 (2018): 512–16. http://dx.doi.org/10.31142/ijtsrd15849.

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Nasr, Ashgan Abdulmanan Ameen, Razvi Ummehani, and Kamble Laxmikant Haribhau. "Identification of MAPK1 Inhibitors from Blumea oxyodonta and Cardiospermum halicacabum for Colorectal Cancer." International Journal of Advance and Applied Research 5, no. 23 (2024): 437–42. https://doi.org/10.5281/zenodo.13788366.

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<strong>Abstract: </strong> Colorectal cancer is significant health concern worldwide. Mitogen-activated protein kinase 1 (MAPK1) is a critical therapeutic target for this malignancy. Natural compounds have potency for different type of cancers due to their diverse structures. Compounds selected for this study were taken from Blumea oxyodonta and Cardiospermum halicacabum. Computational docking analysis revealed promising binding affinities of some of these compounds to MAPK1, suggesting their potential as lead molecules for developing novel therapeutic interventions against colorectal cancer.

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Karuppannan, Sathish Kumar, Mohammed Junaid Hussain Dowlath, Mohamed Khalith SB, Darul Raiyaan G I, Sundarapandian Subramanian, and Kantha Deivi Arunachalam. "Phytochemical and Antibacterial Activity of Cardiospermum halicacabum Against Wound Pathogens." Pharmacognosy Journal 12, no. 6 (2020): 1303–10. http://dx.doi.org/10.5530/pj.2020.12.179.

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Raza, Atif. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7, no. 48 (2013): 3026–33. http://dx.doi.org/10.5897/ajpp2013.3719.

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SUNDARARAJAN, B., G. MAHENDRAN, R. THAMARAISELVI, and B. D. RANJITHA KUMARI. "Biological activities of synthesized silver nanoparticles from Cardiospermum halicacabum L." Bulletin of Materials Science 39, no. 2 (2016): 423–31. http://dx.doi.org/10.1007/s12034-016-1174-2.

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Das, K. Rama, C. Subba Reddi, Aluri Jacob Solomon. Raju, and Janaki Bai Atluri. "Sexual system and pollination ecology of Cardiospermum halicacabum L. (Sapindaceae)." Journal of the Bombay Natural History Society 94 (June 6, 1997): 333–41. https://doi.org/10.5281/zenodo.13657805.

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Byalt, Vyacheslav V., and Michail V. Korshunov. "Several records of alien species new to the flora of the United Arab Emirates (UAE)." Turczaninowia 25, no. 4 (2022): 169–79. http://dx.doi.org/10.14258/turczaninowia.25.4.19.

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The article presents new records for five alien species previously unknown from the flora of United Arab Emirates (UAE): Euphorbia cyathophora Murr. (Euphorbiaceae), Samolus valerandi L. (Myrsinaceae), Oldenlandia umbellata L. (Rubiaceae), Cardiospermum halicacabum L. (Sapindaceae), and Corchorus aestuans L. (Malvaceae s. l. / Tiliaceae). All of them have been recorded for the first time from the emirate of Fujairah in eastern part of the UAE. Euphorbia cyathophora, which is rare in the country, was found only in “Green Oasis Nursery” at Al Dibba town, Oldenlandia umbellata– found at the beginning of the seefront at Fujairah City, and they are new for the flora of the Arabian Peninsula. Samolus valerandi was found only in the “Desert Nurseries Group store 1 (palms)” at village Al Bidiya, Corchorus aestuans – in private nursery at Al Dibba town, and Cardiospermum halicacabum was found in the Masafi friday market, they are new for the flora of Fujairah and UAE. Accepted names, synonyms, spatial distribution, habitat preferences, and species taxonomy with remarks on identification and differentiation from the most similar taxa occurring in the study area, as well as the list of localities are presented. The herbarium materials were transferred to the Herbarium of the Komarov Botanical Institute (LE, Saint-Petersburg, Russia), the duplicates – to the Herbarium of Altai State University (ALTB, Barnaul, Russia) and the Scientific Herbarium of Fujairah (FSH, Wadi Wuraya national park, Fujairah, United Arab Emirates).

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G, Savitha, Vishnupriya V, Surapaneni Krishnamohan, and Geetha RV. "Analysis of phytochemical constituents and antimicrobial properties of Cardiospermum halicacabum Linn." National Journal of Physiology, Pharmacy and Pharmacology 8, no. 9 (2018): 1. http://dx.doi.org/10.5455/njppp.2018.8.0413224042018.

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Shekhawat, Mahipal S., and M. Manokari. "Foliar Micromorphological Evaluation of Cardiospermum halicacabum L. – An Important Medicinal Climber." Open Plant Science Journal 10, no. 1 (2017): 1–9. http://dx.doi.org/10.2174/1874294701710010001.

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Background:Due to non-availability or short supply of original medicinal plants the crude drugs from the plants are adulterated by similarly resembling plants. Micromorphological studies of leaves could help in the identification and authentication of the original medicinal plant from the crude drug materials.Objective:To investigate the qualitative and quantitative micromorphological parameters of the leaves ofCardiospermum halicacabum.Method:The foliar micromorphological parameters such as orientation, stomatal types and morphology; density, distribution of trichomes and stomata; stomatal index and trichome types, paradermal sections were obtained manually by the standard method. The leaves were excised and fixed primarily in formalin, acetic acid and ethyl alcohol solution; cleared in 70% ethanol, bleached with 5% NaOH and rinsed in distilled water. The cleared leaves were used for the study of venation pattern, vein-islets, veinlet terminations and arrangement of crystals.Results:The microscopic examinations revealed the presence of anomocytic and anisocytic types of stomata with the abaxial epidermis of leaves. The stomatal density was 72 and stomatal index reported as 33.1. Glandular trichomes were few with uniseriate stalk, capitate multiseriate and multicellular head. Non-glandular trichomes frequent which were unicellular, uniseriate and bristle in nature. The density of vein islets and veinlet termination was observed as 18 and 13 respectively.Conclusion:The foliar micromorphological (stomata, vein clearing etc.) findings could be used in the proper identification and authentication ofC. halicacabumfrom the crude plant materials which is essential in quality control measures.

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Velmurugan, V., T. Sundarrajan, A. Chandran, and G. Arunachalam. "Evaluation of Diuretic Activity on Leaves Extract of Cardiospermum halicacabum Linn." Research Journal of Pharmacy and Technology 12, no. 4 (2019): 1607. http://dx.doi.org/10.5958/0974-360x.2019.00267.1.

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Rao, T. V. R., and Y. Dave. "Morpho-histogenic studies in the pericarp of Cardiospermum halicacabum L. (Sapindaceae)." Acta Botanica Hungarica 47, no. 3-4 (2005): 419–24. http://dx.doi.org/10.1556/abot.47.2005.3-4.8.

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Kumar, Rajesh, G. Murugananthan, K. Nandakumar, and Sahil Talwar. "Isolation of anxiolytic principle from ethanolic root extract of Cardiospermum halicacabum." Phytomedicine 18, no. 2-3 (2011): 219–23. http://dx.doi.org/10.1016/j.phymed.2010.07.002.

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Sheeba, M. S., and V. V. Asha. "Effect of Cardiospermum halicacabum on ethanol-induced gastric ulcers in rats." Journal of Ethnopharmacology 106, no. 1 (2006): 105–10. http://dx.doi.org/10.1016/j.jep.2005.12.009.

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41

Thiruvengadam, S., K. S. Shreenidhi, and Mohan B. S. Kumar. "Genetic Diversity and Dendrogram of Cardiospermum Halicacabum- An In vitro Study." Biomedical and Pharmacology Journal 11, no. 4 (2018): 2151–56. http://dx.doi.org/10.13005/bpj/1595.

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Cardiospermum halicacabum commonly known as Balloon plant or Love in a puff, a climbing plant often found in tropical and subtropical Africa and Asia. It is widely used in homeopathic medicine for the treatment of arthritis, purulent discharge and others. This particular plant species is becoming endangered due to their extensive use for commercial purposes and genetic diversity at inter-species level arises due to geographical distribution, climate changes and environmental stress. As an initiative for conservation of this species, the present contemplation was done by collecting DNA samples from leaves of the above mentioned plant which were grown in five different locations in and around Chennai and the investigation of their diversity was done using genetically reliable DNA markers like OPA 5, OPA 9, OPA 10, OPB 18, OPC 7, OPN 7 and OPN 12. RAPD PCR was performed. It provided providing information at molecular level and the total number of bands formed, designate the presence of genetic variations among species in different location. Dendrogram was constructed using scoring methods found the differences among the same species arising from evolution, it could be environmental change and technological developmental impacts.

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Linh, Nguyen Thi Thuy, Ba Thi Cham, Nguyen Thi Hoang Anh, et al. "Flavonoid from the aerial parts of Cardiospermum halicacabum L." Vietnam Journal of Chemistry 61, no. 1 (2023): 80–83. http://dx.doi.org/10.1002/vjch.202200033.

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AbstractThe first chemical investigation on Cardiospermum halicacabum L. growing in Vietnam led to the isolation and structural determination of nine flavonoid compounds, including quercetin 3‐O‐β‐D‐glucoside (1), quercetin 3‐O‐α‐L‐rhamnoside (2), quercetin (3), kaempferol 3‐O‐α‐L‐rhamnoside (4), kaempferol (5), apigenin 7‐O‐β‐D‐glucuronide butyl ester (6), apigenin 7‐O‐β‐D‐glucuronide methyl ester (7), apigenin (8), and luteolin (9). Their structures were established by using HR ESI MS, 1D and 2D NMR spectroscopic methods and comparison with those of the related published data. With exceptions to flavonoids 3 and 8, the rest seven compounds (1‐2, 4‐7, and 9) were found for the first time from this plant. Notably, two rare flavonoids (6 and 7) have not yet been reported from the Sapindaceae family before.

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43

Sawicka, Barbara, Barbara Krochmal-Marczak, and Bernadetta Bienia. "Rośliny lecznicze występujące w południowej części Indii." HERBALISM 4, no. 1 (2021): 86–100. http://dx.doi.org/10.12775/herb.2018.008.

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Omówiono i opisano wybrane gatunki znajdujące się zarówno w stanie naturalnym, jak i w uprawie, spośród 7500 roślin leczniczych występujących na terenie Indii – prawdziwego emporium roślin leczniczych i aromatycznych. W codziennym użyciu są tam takie gatunki jak: Azadirachta indica, Cardiospermum halicacabum, Erythrina indica, Gloriosa superba, Jatropha curcas, Moringa oleifera, Phyllanthus amarus, Ssbania grandiflora, Tamarindus indica, Tridax procumbens i Vitex negundo. Najczęściej zaś uprawiane są: Aloe vera, Azadirachta indica, Curcuma longa, Emblica officinalis, Eukaliptus tereticornis, Gloriosa superba, Moringa oleifera, Ricinus communis, Sesamum indicum, Ssbania grandiflora, Solanum americanum, Tamarindus indica i Zingiber officinale. Określono też ich wartość użytkową.

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Mohaddesi, Behzad, and Ashvin Dudhrejiya. "Cardiospermum Halicacabum Seeds: a Potential Human Breast Cancer Cell Lines Growth Inhibitors." Multidisciplinary Cancer Investigation 1, Supplementary 1 (2017): 0. http://dx.doi.org/10.21859/mci-supp-15.

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Sivakali, Vaishnavi, and Lakshmi Thangavelu. "Cytotoxic Activity of Cardiospermum halicacabum L. against Oral Cancer Cell Lines.-SCC25." Asian Journal of Biological and Life sciences 9, no. 1 (2020): 88–91. http://dx.doi.org/10.5530/ajbls.2020.9.13.

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46

Jayanthi, G., and M. Jagadeesan. "Composition of seed oil of Cardiospermum halicacabum L. var. luridum Blume (Adelb)." Scientific Transactions in Enviornment and Technovation 1, no. 4 (2008): 215–17. http://dx.doi.org/10.20894/stet.116.001.004.009.

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Respondek, U. "Cardiospermum halicacabum - Eine Prüfung mit den Potenzen D 6 und C 30." Zeitschrift für Klassische Homöopathie 34, no. 03 (2007): 107–14. http://dx.doi.org/10.1055/s-2006-938369.

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48

Sadique, J., T. Chandra, V. Thenmozhi, and V. Elango. "Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation." Journal of Ethnopharmacology 19, no. 2 (1987): 201–12. http://dx.doi.org/10.1016/0378-8741(87)90042-0.

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Jeyadevi, R., T. Sivasudha, A. Ilavarasi, and N. Thajuddin. "Chemical Constituents and Antimicrobial Activity of Indian Green Leafy Vegetable Cardiospermum halicacabum." Indian Journal of Microbiology 53, no. 2 (2012): 208–13. http://dx.doi.org/10.1007/s12088-012-0333-4.

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Hemapoojavalli, G., C. Thiyagarajan, S. Ruthra, and S. Anantha Kumar. "Phytochemicals analysis and antibacterial activity of Cardiospermum halicacabum against clinical MDR Pathogens." International Journal of Clinical Biology and Biochemistry 1, no. 2 (2019): 27–30. http://dx.doi.org/10.33545/26646188.2019.v1.i2a.12.

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