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Journal articles on the topic 'Cardiovascular Complications Diabetes Mellitus HbA1c Mean Platelet Volume'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Dipeeka, D. Patel, Chunilal Koitiya Nayan, Gajjar Dipti, and Gulabbhai Keyurkumar. "The Study of Relationship Between Glycemic Control and Platelet Activity in Type 2 Diabetes Mellitus Patients of Tertiary Care Hospital at Rajpipla, Gujarat." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 166–69. https://doi.org/10.5281/zenodo.12717182.

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<strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder characterized by chronic hyperglycemia. Glycemic control in T2DM patients is crucial for minimizing complications, one of which is altered platelet activity, contributing to increased cardiovascular risk. This study aims to investigate the relationship between glycemic control and platelet activity in T2DM patients over a six-month period. <strong>Materials and Methods: </strong>This prospective study was conducted at GMERS Medical College, Rajpipla, Gujarat, involving 110 T2DM patient

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2

Hussain, Ali Rangwala, and Sankala Manoj. "Association of Mean Platelet Volume with That of the Diabetic Status of Patients with T2DM." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 1520–26. https://doi.org/10.5281/zenodo.11239122.

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<strong>Introduction: </strong>Diabetes mellitus (DM) affects about 10% of the world’s population and is developing quickly. Chronic hyperglycemia in DM affects endothelial function and arteries. Controlling blood sugar affects microvascular (nephropathy, retinopathy) and macrovascular (heart disease). MPV might be a biomarker for DM-related vascular issues. Cardiovascular events, excluding DM, had elevated MPV. <strong>Aims and Objectives:</strong> This study evaluates the correlation between “Mean Platelet Volume (MPV)” and the state of “Type 2 Diabetes

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3

Sinha, Anirban, Aparajita Samaddar, and Manas Talukdar. "Platelet indices in controlled and uncontrolled type 2 diabetes mellitus: A cross sectional study." Panacea Journal of Medical Sciences 12, no. 3 (2022): 533–37. http://dx.doi.org/10.18231/j.pjms.2022.101.

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Diabetes is an emerging health problem across the world. Underlying prothrombotic state leads to cardiovascular complications in diabetics especially those with poor glycemic control. Though multiple mechanisms are responsible, platelet activation plays a major role in the pathogenesis of prothrobotic state. Platelet activation causes increase in their size which is represented by Mean Platelet Volume (MPV) whereas variation in their size associated with release reaction is reflected by Platelet Distribution Width (PDW). So MPV and PDW together may help to detect emergence of prothrombotic sta

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4

Kodiatte, Thomas Alex, Udaya Kumar Manikyam, Suraksha Bellur Rao, et al. "Mean Platelet Volume in Type 2 Diabetes Mellitus." Journal of Laboratory Physicians 4, no. 01 (2012): 005–9. http://dx.doi.org/10.4103/0974-2727.98662.

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ABSTRACT Context: diabetes mellitus is a global pandemic. The increased platelet activity may play a role in the development of vascular complications of this metabolic disorder. The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Larger platelets are younger and exhibit more activity. Aims: to determine the MPV in diabetics compared to nondiabetics, to see if there is a difference in MPV between diabetics with and without vascular complications, and to determine the correlation of MPV with fasting blood glucose, glycosylated hemoglobin (HbA1c), body-m

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5

Nakhro, Nuneno, Poonam Khambra, Sonam Sharma, and T. Banikanta Singha. "Metabolic consequences on platelet parameters: Mean platelet volume and platelet distribution width in type 2 diabetes mellitus." Asian Journal of Medical Sciences 15, no. 10 (2024): 45–50. https://doi.org/10.71152/ajms.v15i10.4154.

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Background: Diabetes mellitus encompasses metabolic disorders marked by chronic hyperglycemia, leading to various complications. It is considered a prothrombotic state associated with increased platelet reactivity. Parameters such as mean platelet volume (MPV) and platelet distribution width (PDW), which are indicative of platelet size, enzymatic activity, and prothrombotic risk, can be readily assessed during routine hematological analysis, facilitating early detection of this prothrombotic state. Aims and Objectives: The study aimed to investigate the varied alterations in platelet parameter

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Nakhro, Nuneno, Poonam Khambra, Sonam Sharma, and T. Banikanta Singha. "Metabolic consequences on platelet parameters: Mean platelet volume and platelet distribution width in type 2 diabetes mellitus." Asian Journal of Medical Sciences 15, no. 10 (2024): 45–50. http://dx.doi.org/10.3126/ajms.v15i10.67644.

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Background: Diabetes mellitus encompasses metabolic disorders marked by chronic hyperglycemia, leading to various complications. It is considered a prothrombotic state associated with increased platelet reactivity. Parameters such as mean platelet volume (MPV) and platelet distribution width (PDW), which are indicative of platelet size, enzymatic activity, and prothrombotic risk, can be readily assessed during routine hematological analysis, facilitating early detection of this prothrombotic state. Aims and Objectives: The study aimed to investigate the varied alterations in platelet parameter

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7

Dubey, Ishan, Bindu Singh Gaur, and Roma Singh. "A study to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications." International Journal of Research in Medical Sciences 5, no. 3 (2017): 1042. http://dx.doi.org/10.18203/2320-6012.ijrms20170659.

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Background: Diabetes Mellitus is a global pandemic disease. The increased platelet activity is emphasized to play a role in the development of vascular complications of the metabolic disorder. Mean platelet volume (MPV) is an indicator of average size and activity of platelets. This study was conducted to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications.Methods: Total of 100 subjects was enrolled in the study. Sample for glucose estimation and platelet indices were collected and estimation were carried out by the auto-analyzer

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8

Kamlesh, Kumar Meena, Solanki Arun, Lal Jat Shankar, Samaria Anil, and Monika. "Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus and Its Correlation with Albuminuria and HbA1c Levels." International Journal of Pharmaceutical and Clinical Research 15, no. 8 (2023): 1578–81. https://doi.org/10.5281/zenodo.11528678.

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Diabetes mellitus is a heterogeneous group of disorders that have in common the metabolic defect of hyperglycemia. The mechanisms by which this hyperglycaemia is produced vary, and they may be acquired, genetic or environmental. This ultimately results in impaired pancreatic insulin secretion, impaired peripheral utilization of glucose, and enhanced hepatic glucose production. The prevalence of diabetes according to the WHO criteria was 5.6% among the urban areas and 2.7% among rural areas. The mean platelet volume is one of the hematological parameters used to assess platelet function and act

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9

Milind Jivanlal Manvar, Rajesh Sukumar Roy, Viralkumar Mohanbhai Jadav, and Amalkumar Bankimchandra Bhattacharya. "To determine the relation of mean platelet volume with diabetes mellitus." Asian Journal of Medical Sciences 13, no. 9 (2022): 130–35. http://dx.doi.org/10.3126/ajms.v13i9.44690.

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Background: Diabetes mellitus (DM) is a complex metabolic disorder portrayed by chronic hyperglycemia bringing about intricacies influencing the peripheral nerves, kidneys, eyes, and macrovascular structures. Mean platelet volume (MPV) is also considered to impact the advancement of microvascular complications of diabetes mellitus which has been looked for in this study. Aims and Objectives: The aims of this study were as follows: (1) To study association of MPV with Nephropathy and Retinopathy in Diabetes. (2) To Study correlation of MPV with hemoglobin A1c (HbA1C), fasting blood sugar, post-

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10

Milind Jivanlal Manvar, Rajesh Sukumar Roy, Viralkumar Mohanbhai Jadav, and Amalkumar Bankimchandra Bhattacharya. "To determine the relation of mean platelet volume with diabetes mellitus." Asian Journal of Medical Sciences 13, no. 9 (2022): 130–35. https://doi.org/10.71152/ajms.v13i9.3885.

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Background: Diabetes mellitus (DM) is a complex metabolic disorder portrayed by chronic hyperglycemia bringing about intricacies influencing the peripheral nerves, kidneys, eyes, and macrovascular structures. Mean platelet volume (MPV) is also considered to impact the advancement of microvascular complications of diabetes mellitus which has been looked for in this study. Aims and Objectives: The aims of this study were as follows: (1) To study association of MPV with Nephropathy and Retinopathy in Diabetes. (2) To Study correlation of MPV with hemoglobin A1c (HbA1C), fasting blood sugar, post-

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11

Khare, Manika. "Role of MPV in Early Diagnosis of Vascular Complication in Diabetic Patient." American Journal of Clinical and Medical Case Reports 2, no. 1 (2022): 01–02. http://dx.doi.org/10.33597/ajcmcr-v2-id1007.

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Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia resulting from deficiency of insulin. Among platelet indices, Mean Platelet Volume (MPV) demonstrates the changes in rate of platelet production. Increase in MPV is seen in metabolic syndrome, stroke and diabetes. In these 100 diabetics and 100 control subjects were taken and their HbA1c was correlated with the MPV level of these subjects. A significant correlation was found between the MPV and Hba1c levels. Hence raised MPV levels can be used as an early indicator for the complications of diabetes.

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12

Thakur, Aman, Purbesh Adhikari, Mona Dahal, Paricha Upadhyaya, Smriti Karki, and Anju Pradhan. "Role of mean platelet volume in patients with type 2 diabetes mellitus." Indian Journal of Pathology and Oncology 10, no. 2 (2023): 126–31. http://dx.doi.org/10.18231/j.ijpo.2023.028.

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In type 2 diabetes mellitus, increased platelet activity is crucial for the emergence of vascular complications. Mean platelet volume (MPV), an indicator of enhanced platelet activity, may be helpful in identifying the thromboembolic events that lead to these vascular complications. This study aims to assess MPV in Type 2 Diabetes patients and investigate the relationship between MPV and glycaemic and diabetic complications. : A comparative cross-sectional study was carried out on 266 subjects (133 diabetic patients and 133 nondiabetic controls) at B.P Koirala Institute of Health Sciences for

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V, Soumya, Sukesh Sukesh, Rubina M P, Mohammed Safeer T K, Riyas Basheer K B, and Nayana K Babu. "Platelet Metrics In Type 2 Diabetes: A Practical Tool For Assessing Vascular Complications." Journal of Neonatal Surgery 14, no. 28S (2025): 1014–19. https://doi.org/10.63682/jns.v14i28s.7332.

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Background: Chronic metabolic disorder Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, which is associated with a range of complications, particularly vascular complications that significantly contribute to morbidity and mortality among patients. The ability to predict these complications early is crucial for preventive strategies and patient management. This study provides an overview of the practicality of platelet parameters for predicting vascular complications in type 2 diabetes patients, highlighting their importance in diabetes management and the potential benefits of

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Sangapur, Shivakanth M., Darshan R. S., Sharanabasappa, and Baldev Meena. "Platelet indices and their correlation with HbA1c and association with microvascular complications in type-2 diabetes mellitus." International Journal of Research in Medical Sciences 11, no. 5 (2023): 1594–99. http://dx.doi.org/10.18203/2320-6012.ijrms20231321.

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Background: Depending on the aetiology of the DM, factors contributing to hyperglycaemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production. Mean platelet volume (MPV) and platelet distribution width (PDW) are important, simple, effortless, and cost-effective tools measured by hematology analyser which assess the volume and function of platelets. Analysing the platelet parameters can act as an alarm for progression of complications of DM. Hence, we studied the platelet parameters in diabetic patients with good and poor glycaemic control and their

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15

Swetaba, C. Solanki, Agrawal Veeha, and L. Parmar Tejendrasinh. "The Significance of Mean Platelet Volume in Type 2 Diabetes Patients." International Journal of Toxicological and Pharmacological Research 14, no. 11 (2024): 96–101. https://doi.org/10.5281/zenodo.14562615.

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<strong>Background and Aim: </strong>Diabetes mellitus has emerged as a significant global health crisis. Heightened platelet activity could contribute to the emergence of vascular complications associated with this metabolic disorder. The mean platelet volume (MPV) serves as a crucial marker for assessing the average size and functionality of platelets. Research indicates that larger platelets are typically younger and demonstrate increased activity levels. This study focused on comparing mean platelet volume (MPV) in patients with Type 2 Diabetes against non-diabetic controls. It also e

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Swetaba, C. Solanki, Agrawal Veeha, and L. Parmar Tejendrasinh. "The Significance of Mean Platelet Volume in Type 2 Diabetes Patients." International Journal of Toxicological and Pharmacological Research 14, no. 11 (2024): 164–69. https://doi.org/10.5281/zenodo.14588853.

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<strong>Background and Aim: </strong>Diabetes mellitus has emerged as a significant global health crisis. Heightened platelet activity could contribute to the emergence of vascular complications associated with this metabolic disorder. The mean platelet volume (MPV) serves as a crucial marker for assessing the average size and functionality of platelets. Research indicates that larger platelets are typically younger and demonstrate increased activity levels. This study focused on comparing mean platelet volume (MPV) in patients with Type 2 Diabetes against non-diabetic controls. It also e

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17

Aygün, Kemal, Ayça Asma Sakalli, Halime Seda Küçükerdem, Olgu Aygün, and Özden Gökdemir. "Assessment of neutrophil/lymphocyte ratio and mean platelet volume values in patients with diabetes mellitus diagnosis: A case–control study." Medicine 103, no. 37 (2024): e39661. http://dx.doi.org/10.1097/md.0000000000039661.

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Diabetes mellitus, fundamentally characterized by hyperglycemia, leads to significant metabolic disturbances. Type 2 diabetes mellitus is a chronic, inflammatory, preventable metabolic disease that is a significant health issue globally. The neutrophil-to-lymphocyte ratio (NLR) is an essential marker of systemic inflammation. We aimed to reveal the relationship between long-term glucose control and NLR, mean platelet volume (MPV), and red blood cell width in patients with type 2 diabetes. This was a retrospective case–control study. A total of 3532 applications in 2 years time were identified.

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18

Iqbal, Shamal, Kanwal Nazir Arbab, Maria Tasneem Khattak, Ambreen Ali, Alia Banori, and Mehwish Iqbal Khan. "A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study Design." Pakistan Journal of Medical and Health Sciences 16, no. 9 (2022): 850–52. http://dx.doi.org/10.53350/pjmhs22169850.

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Objective: The aim of the study is to evaluate the reactivity of platelet parameters in a patient suffering from Type 2 diabetes mellitus. Place and duration of study: The study is conducted at Pak International Medical College Hayatabad Peshawar (PIMC) during march 2021 march 2022. Material and Method: Cross sectional hospital based study design is carried out on 300 diabetic patients having type 2 diabetes mellitus which is considered as a test group and compared with 300 normal blood glucose levels containing individuals which is considered as a control group. The blood samples of diabetes

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19

Ramachandran, Tamilselvi, Saranya Balasubramanian, Bharathi ..., and Shankar Radhakrishnan. "Study of Association of Hematological Parameters with HbA1c and Microvascular Complications in type II Diabetes Mellitus." Indian Journal of Medical and Health Sciences 5, no. 1 (2018): 21–26. http://dx.doi.org/10.21088/ijmhs.2347.9981.5118.4.

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Background: Studies have proved that complications of diabetes particularly the microvascular complications are strongly associated with HbA1c levels [2,3]. The higher the Hba1c values the higher the chance of developing complications. Hba1c values have thus become a valuable marker in assessing the glycemic control and the risk of developing complications as it is convenient, reproducible and efficient in reflecting chronic hyperglycemia. Aim: To assess the association and correlation of haematological parameters with HbA1c levels in type II diabetes mellitus patients. Methodology: A cross-se

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20

Paul, Arijit, Soumyadip Das, Koushik Bose, and Rupam Karmakar. "Platelet Indices: Predicting Retinopathy in Patients with Type 2 Diabetes Mellitus." Medical Journal of Dr. D.Y. Patil Vidyapeeth 17, no. 6 (2024): 1231–35. http://dx.doi.org/10.4103/mjdrdypu.mjdrdypu_968_23.

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Background: Diabetes mellitus (T2DM) is a metabolic disorder, characterized by insulin resistance and varying degrees of hyperglycemia, leading to several macrovascular and microvascular complications. In recent years, altered platelet morphology and dysfunctions are reported in patients with T2DM. Platelet indices, namely plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW), can predict altered platelet morphology and dysfunction which leads to microvascular complications, such as retinopathy. Aims: This study was aimed at comparing platelet indices in individ

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21

Ashraf, Jahanzaib, Uffaq Farrukh, Amanullah Bhalli, and Uneeba Syed. "Comparison of Mean Platelet Volume in Patients with and Without Diabetes Mellitus at a Tertiary Care Hospital." Biological and Clinical Sciences Research Journal 6, no. 3 (2025): 31–34. https://doi.org/10.54112/bcsrj.v6i3.1607.

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Mean Platelet Volume (MPV) is a platelet activation marker linked to various cardiovascular diseases. Type 2 Diabetes Mellitus (T2DM) is known to increase the risk of thrombosis, and changes in platelet characteristics, including MPV, may contribute to this risk. Objective: This study aimed to compare the MPV in patients with and without T2DM at a tertiary care hospital. Methods: This randomized controlled trial was conducted at Akhtar Saeed Trust Hospital, Lahore, with 98 participants (49 diabetic and 49 non-diabetic) from 18 October 2024 Till 17 January 2025. Data were collected through non-

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Dervisevic, Emina, Anes Jogunčić, Muamer Dervišević, et al. "Increased mean platelet volume is associated with acute myocardial infarction in patients with diabetes mellitus type 2." International Journal of Research in Medical Sciences 10, no. 7 (2022): 1426. http://dx.doi.org/10.18203/2320-6012.ijrms20221784.

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Background: The correlation between diabetes mellitus and acute myocardial infarction is greater every day. The mean platelet volume (MPV), which is the determinant of platelet function, is an independent risk factor for the cardiovascular disease. The aim of the study was to investigate the effect of each disease (hypothyroidism, hypertension, myocardial infarction) individually and combined on MPV in diabetic patients.Methods: The cross-sectional study included 102 patients who suffer from diabetes mellitus type 2 (DMT2), of both sexes (46 females, 56 males), with the average age of 58.91 (S

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Jyoti, Kumari, and Kumar Amit. "Assessment of the Role of Mean Platelet Volume in Patients with Type 2 Diabetes Mellitus: An Observational Study." International Journal of Current Pharmaceutical Review and Research 15, no. 12 (2023): 156–60. https://doi.org/10.5281/zenodo.11371938.

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Aim: The aim of the present study was to determine the correlation of MPV with fasting blood glucose,glycosylated hemoglobin (HbA1c), body-mass index, and duration of diabetes in the diabetic patients.Material & Methods: This was a cross-sectional study carried out in Department of Pathology, including 100patients who were already diagnosed to have Type 2 DM and 100 nondiabetic subjects without known coronaryartery disease in between the duration of 12 months.Results: There were more male as compared to females in both groups. MPV was significantly raised in thediabetic population in compa

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Amoghasiddha, S. Jyoti, K. Arun., and Shankar Anjali. "A Cross-Sectional Study For Evaluation of Platelet Indices in Patients With Type 2 Diabetes Mellitus." International Journal of Pharmaceutical and Clinical Research 15, no. 11 (2023): 744–49. https://doi.org/10.5281/zenodo.11220890.

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<strong>Background: </strong>Diabetes mellitus has become a major global health problem. It’s a state of hyperglycemia which causes spectrum of long term systemic complications having considerable impact on individuals in their most productive years. Altered platelets have been reported in such patients and has been considered as a ‘prothrombotic state’. Identification of such patients can be easily made by simple routine haematological analysis which is a cost-effective tool that could possibly benefit the diabetic patients by preventive actions. <strong>Methods:&n

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Ahmed, Sawer Sabri. "A study to evaluate platelet parameters in patients with type 2 diabetes mellitus: A case-control study." Medical Journal of Babylon 21, no. 1 (2024): 124–28. http://dx.doi.org/10.4103/mjbl.mjbl_408_23.

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Abstract Background: Diabetes mellitus is a multifactorial disorder characterized by persistent elevation of plasma glucose and permanent complications of both small and large vessels. The high mortality rates, a decline in quality of life, and high morbidity rates are mostly caused by these problems. When blood vessels are injured, the normal hemostatic process depends heavily on platelets to maintain their integrity. Objectives: This study aimed at comparing various platelet indices between people with type II diabetes and people who appeared to be in good health status. Materials and Method

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Hussein, Hussein Abker, Fatima-Elzhra Ahmed Elmagzoub, Dalia Mohammed Babikir, and Mouna Adel Samaan. "THE EFFECT OF METFORMIN AND GLIMEPIRIDE ON PLATELET COUNT AND INDICES AMONG DIABETIC PATIENTS WERE ATTENDING JABER ABU ALIZ DIABETIC CENTER IN KHARTOUM STATE." Journal of Biomedical and Pharmaceutical Research 10, no. 1 (2021): 93–98. http://dx.doi.org/10.32553/jbpr.v10i1.846.

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Diabetes mellitus (DM) is a global pandemic, Platelets have crucial role in accelerated atherosclerosis and thrombosis which characterize DM. Aim The aim of the study was to detect the effect of two major oral hypoglycemic drugs (Metformin and Glimepiride) on platelet count and indices{ MPV (Mean platelet volume), PLCR (platelet large cell ratio),PDW (platelet distribution width)}.Beside, to studythe effects of variation induration of the drug, dose of drug, HbA1C level and associated complications. Material and methods A case control study was performed 146subjects 50

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Gamage, V. N. U., M. G. M. Mohotti, and K. A. C. Wickramaratne. "Differences in platelet indices between type-2 diabetes mellitus patients with and without microvascular complications at Teaching Hospital, Karapitiya." Sri Lanka Journal of Haematology 15, no. 1 (2024): 19–26. http://dx.doi.org/10.4038/tsljh.v15i1.11.

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Type-2 Diabetes Mellitus (T2DM) is associated with a greater amount of morbidity and mortality due to microvascular and macrovascular complications. Involvement of platelets in vascular complications of diabetes is well known and changes in platelet indices have been identified as predictors of these vascular complications. This study was carried out to determine the changes in platelet indices in patients with T2DM. This was a comparative cross sectional study conducted at Teaching Hospital, Karapitiya. Study subjects included T2DM patients with microvascular complications as study group and

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Giraldo-Gonzalez, German Camilo, Cristian Giraldo-Guzman, Abelardo Montenegro-Cantillo, et al. "Hospital Outcomes of Adult Diabetic Patients by Glycated Hemoglobin Level in Nonsurgical Pathology in a High-Complexity Institution." Clinical Medicine Insights: Endocrinology and Diabetes 12 (January 2019): 117955141988267. http://dx.doi.org/10.1177/1179551419882676.

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Recent evidence supports the relationship between in-hospital hyperglycemia and inpatient complications. Besides, glycated hemoglobin (HbA1c) can predict the clinical course of patients with type 2 diabetes mellitus (DM2) during hospital stays. This study aimed to assess the relationship between HbA1c levels and inpatient outcomes. Type 2 diabetes mellitus patients with age greater than 18 years, hospital length of stay greater than 24 hours, and one HbA1c report during their in-hospital management were included. All the electronic care records of patients admitted at the Clinical Versalles, a

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Zvetkova, Elissaveta, Ivan Ivanov, Eugeni Koytchev, et al. "Hematological and Hemorheological Parameters of Blood Platelets as Biomarkers in Diabetes Mellitus Type 2: A Comprehensive Review." Applied Sciences 14, no. 11 (2024): 4684. http://dx.doi.org/10.3390/app14114684.

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Diabetes mellitus type 2 (DM2) is a hypercoagulable state with enhanced platelet (PLT) activation and increased clotting factor production. Simultaneously, the fibrinolytic cell system is inhibited due to the formation of clots with high fibrinolysis resistance. The stages of PLT “activation” have been well characterized microscopically, morphometrically, and nanomechanically using a light microscope, transmission electron microscope (TEM), scanning electron microscope (SEM), and atomic force microscope (AFM). Thrombocytes in an “activated” (procoagulant) state play a central role in two main

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Abel-Rahman, Sayed M., Essam S. Badawy, Ahmad A. Amer, and Dalal Fekry. "Mean platelet volume as a risk factor in pregnant diabetic women." Egyptian Journal of Internal Medicine 24, no. 2 (2012): 32–36. http://dx.doi.org/10.7123/01.ejim.0000419581.67334.75.

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Abstract Background Diabetes is an established risk factor for cardiovascular disease (CVD); therefore, the subset of women with gestational diabetes mellitus (GDM) who develop type 2 diabetes mellitus is at an increased risk for developing CVD in the future. Objectives To assess the platelet count and mean platelet volume (MPV) of pregnant women with GDM and gestational impaired glucose tolerance (GIGT) to determine whether GDM and GIGT are risk factors for future development of CVD. Patients and methods A 50 g oral glucose load (OGL) was administered to all participants (400 pregnant women),

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Balceniuk, Mark D., Lauren E. Trakimas, Claudia Aghaie, et al. "Aspirin use is associated with decreased radiologically-determined thrombus sac volume in abdominal aortic aneurysms." Vascular 26, no. 4 (2018): 440–44. http://dx.doi.org/10.1177/1708538118762214.

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Introduction Formation and renewal of intramural thrombus is associated with inflammation, and contributes to the complexity of aneurysm repair. Current cardiovascular pharmacotherapy includes several inflammatory modulators such as aspirin, statins, clopidogrel, and angiotensin-converting enzyme inhibitors. The purpose of our study was to investigate the effect of these inflammatory modulators on radiographically-determined thrombus sac volume. Methods Pre-operative computed tomography scans were reviewed in patients who underwent elective infrarenal aortic aneurysm repair. Thrombus sac volum

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AL-Maadheed, Ikbal Mohamad Hachim, A. E. Kadhom, and M. A. Bahaaldeen. "Hematological Parameters in Type 2 Diabetes Mellitus." Гематология. Трансфузиология. Восточная Европа 11, no. 2 (2025): 174–78. https://doi.org/10.34883/pi.2025.11.2.003.

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Introduction. Disturbances of hemostatic mechanism have been frequently described in patients with diabetes mellitus and have been associated with the development of diabetic complications and increased incidence of cardiovascular events in diabetic subjects. Purpose. Aim of the study is to assess the hematological parameters in CVD patients with type 2 diabetes mellitus. Materials and methods. During the period of three months October, November and December 2010, forty-nine patients from Baghdad Teaching Hospital / Medical City were included in this study. All of them were adults with type 2

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Yenigun, Ezgi Coskun, Cenk Aypak, Didem Turgut, et al. "Is there a relation between mean platelet volume and chronic kidney disease stages in diabetic patients?" International Journal of Clinical and Experimental Medicine 9, no. 1 (2016): 330–35. https://doi.org/10.5281/zenodo.46921.

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Objective: Chronic kidney disesase (CKD) is a state of atherosclerotic and chronic inflammation and as the estimated glomerular filtration rate (GFR) declines, cardiovascular disease (CVD) risk and inflammation increase. Mean platelet volume (MPV) has shown to be influenced by cardiovascular risk factors. The aim of this study was to evaluate the relationship between MPV and CKD. Methods: This is prospective study of a total of 812 CKD patients. Patients with CKD were assigned to into the five groups depending on estimated GFR which were calculated by Modification of Diet in Renal Disease (MDR

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Shivendra, Nagiya Reena Singh and Anshul Sharma. "ROLE OF MPV IN COMPLICATION OF DIABETES MELLITUS 2." August 18, 2022. https://doi.org/10.5281/zenodo.7056326.

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Diabetes mellitus (DM) is a global health problem with increased risk of vascular disease. Platelets may contribute to the development of vascular complications in subjects with diabetes. Larger platelets are more reactive than smaller ones therefore, mean platelet volume (MPV) can be used as a marker for platelet activity. Aim and Objectives: To determine the role of MPV in severity and complications of DM2 as compared to non diabetic patients and to determine the effect of glycemic control and duration of diabetes on platelet parameters. This is a cross-sectional prospective study to evaluat

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Shanthi, B., Jainulavudeen Mohamed Rabeek, Mary Chandrika Anton, and V. S. Kalai Selvi. "Association of Glycemic Control with Platelet Indices Among Patients with Type 2 Diabetes Mellitus." International Journal of Life Science and Pharma Research, July 1, 2022, L63—L68. http://dx.doi.org/10.22376/ijpbs/lpr.2022.12.4.l63-68.

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Diabetes mellitus, a chronic metabolic disease affects various organs of the body on a long-term basis. Diabetes results in haematological changes that lead to development of complications such as hypercoagulability, anemia and cardiovascular disease (CVD). Hematological parameters play an important role in the treatment and follow up of diabetic patients. Hence, the objective of the study is to compare the mean levels of hematological parameters namely Platelet Distribution Width (PDW), Mean Platelet Volume (MPV) and Plateletcrit (PCT) between the type 2 diabetic patients with HbA1c ≥ 6.5 wit

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Manea, Viorel, Daniel-Corneliu Leucuța, Călin Pop, and Mircea-Ioachim Popescu. "The biomarkers associated with non-dipper pattern in patients with type 2 diabetes with hypertension." Medicine and Pharmacy Reports, October 4, 2024. http://dx.doi.org/10.15386/mpr-2796.

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Background and aims. The non-dipper pattern is present in about 50 percent of patients with type 2 diabetes (T2D) and hypertension, a status associated with more frequent cardiovascular complications and restrained prognosis. This study aimed to identify simple biomarkers that can be used for the classification of dipper and non-dipper individuals with type 2 diabetes and hypertension. Method. 138 consecutive patients with type 2 diabetes mellitus (DM) and hypertension underwent 24-hour ambulatory blood pressure monitoring (ABPM), 54 (39.1%) dippers and 84 (60.9%) non-dippers; CBC and determin

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Ashwani, K., R. Raghavendra, and B. Sujatha. "Effectiveness of platelet indices in predicting type 2 diabetes mellitus microvascular complications." NEW ARMENIAN MEDICAL JOURNAL, 2022, 118–24. http://dx.doi.org/10.56936/18290825-2022.16.2-118.

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Objective - This study was conducted to evaluate the efficacy of platelet indices, namely mean platelet volume, platelet distribution width, plateletcrit and platelet count for prediction of microvascular complications of type 2 diabetes mellitus. Methods - A hospital-based, single-centre, observational, matched case-control study was conducted. A total of 120 diabetic cases and 120 non-diabetic controls were recruited and various biochemical parameters (fasting and post-prandial blood glucose, HbA1c, mean platelet volume, platelet distribution width, plateletcrit, platelet count and others) w

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.B, Anitha, Veena Juliette .A, and Murali T. "CORRELATION OF MEAN PLATELET VOLUME WITH GLYCEMIC INDEX IN PATIENTS WITH TYPE II DIABETES MELLITUS – AN OBSERVATIONAL STUDY." INDIAN JOURNAL OF APPLIED RESEARCH, February 1, 2021, 24–26. http://dx.doi.org/10.36106/ijar/4713706.

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Type II Diabetes mellitus (TII DM) is a major global health problem. TII DM is characterized by the prothrombotic state of platelets which owes to the persistent hyperglycemia and insulin resistance, causing injury to pericytes and endothelium. Increased platelet activity is believed to be associated with the development of vascular complications in TII DM. Mean Platelet Volume (MPV), a marker of platelet function which can be used to assess the vascular complications. This is an observational study including 150 TII DM patients attending Diabetology OPD in Coimbatore Medical College& Hosp

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Qureishi, Rifat, S. K. Sutrakar, P. C. Kol, UR Singh, and M. H. Usmani. "“MEAN PLATELET VOLUME CORRELATED TO GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS”." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, April 1, 2021, 62–64. http://dx.doi.org/10.36106/ijsr/6922290.

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Background: Diabetes mellitus (DM) is becoming a global pandemic. The number of people with diabetes in India increased from 26·0 million in 1990 to 65·0 million in 2016. Diabetes mellitus (DM) has been considered as a 'prothrombotic state' with enhanced platelet reactivity. Diabetic patients have an increased risk of developing micro and macro vascular diseases, and platelets may be involved as putative agents owing to their altered morphology, function and activation. It is an established fact that the value of glycated hemoglobin (HbA1c), a marker of long-term glucoregulation, should be kep

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Singh, Ramnik, Sonam Billawaria, Gauri Patil, Rutuja Khawale, and Devika Borade. "Study of Platelet Indices as a Predictive Parameter for Diabetic Complications in Type II Diabetes Mellitu-A Cross Sectional Study." Journal of Diabetes Research Reviews & Reports, April 30, 2024, 1–3. http://dx.doi.org/10.47363/jdrr/2024(6)182.

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Introduction: Diabetes Mellitus is a prothrombotic state with enhanced platelet activity. The enhanced platelet activity may result in the development of microvascular and macrovascular complications. Platelet indices i.e. Mean Platelet volume (MPV), Platelet Distribution Width (PDW) are routinely available in alllaboratories and can be used to study as a prognostic marker for the patients. Aim: To evaluate platelet indices in patients with type 2 diabetes mellitus. Methods and Material: Cross sectional study was conducted in the Department of Pathology at a tertiary care centre over a period

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Rasheeda, Rasheeda, Renuka Patil, and Krishnaraj Upadhyaya. "TO KNOW THE ASSOCIATION OF PLATELET ACTIVITY ON GLYCEMIC STATUS AND VASCULAR COMPLICATIONS IN DIABETES MELLITUS." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, April 1, 2023, 23–24. http://dx.doi.org/10.36106/ijsr/8212640.

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Background: Diabetes mellitus is a global pandemic disease. Hyperglycemia contributes to greater platelet reactivity through direct effects and by promoting glycation of proteins. Mean platelet volume(MPV) and Mean platelet count(MPC) is an indicator of average size and activity of the platelets and is high in diabetes mellitus. Objectives: 1) To nd the association between MPC and MPVwith HBA1C in diabetic patients. 2) To nd the association of MPC and MPV with vascular complications in diabetic patients. Methodology: A retrospective study conducted in the Department of Pathology from January

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Shantveer, B., and Suresh S Harsoor. "CORRELATION OF MEAN PLATELET VOLUME AND HbA1c WITH DIABETIC RETINOPATHY IN PATIENTS OF TYPE 2 DIABETES MELLITUS." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, November 1, 2024, 26–27. https://doi.org/10.36106/ijsr/3500743.

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Background: Diabetes Mellitus (DM) is a group of metabolic disorders, characterized by chronic hyperglycaemia, metabolic abnormalities which lead to multiple complications. Mean Platelet Volume (MPV), a marker of the platelet function and activation. The increased platelet activity is emphasized to play a role in the development of vascular complications of this metabolic disorder. Though MPV appears to be a simple parameter; it can indirectly gauge vascular complication in diabetic patient easily at a comparatively lower cost. Greater values of MPV signify larger platelets, which are more act

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P., Geetha, Deepa N., M. Immanuel Jebastine, and Revetha S. "Prospective study on Platelet Count Indices as Predictive Biomarkers for Development of Complications in patients with Type 2 Diabetes Mellitus." Asian Journal of Pharmacy and Technology, March 5, 2025, 13–16. https://doi.org/10.52711/2231-5713.2025.00003.

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Diabetic patients often exhibit elevated platelet reactivity, attributed to the direct impact of hyperglycemia and glycation of platelet proteins. Increased platelet activity has been associated with the development of vascular complications. Insulin plays a crucial role in preventing platelet activation, implying that deficient insulin levels may lead to heightened platelet reactivity. The objective of our study was to compare platelet count and predictive biomarkers in patients with type 2 diabetes mellitus (DM) who had complications versus those without complications. We aimed for a sample

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Ahluwalia, Ramnik Singh, Sunil V. Jagtap, Devika Suresh Borade, Rutuja Khawale, and Sonam Billawaria. "Association of Platelet Indices with Diabetic Complications: A Cross-sectional Study." JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2024. http://dx.doi.org/10.7860/jcdr/2024/65994.19061.

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Introduction: Diabetes Mellitus is a prothrombotic state characterised by enhanced platelet activity, which may lead to microvascular and macrovascular complications. Platelet indices, such as Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW), are routinely available in laboratories and can serve as a prognostic markers for patients. Aim: To evaluate platelet indices in patients with Type 2 Diabetes Mellitus (T2DM) and associated complications. Materials and Methods: A cross-sectional study was conducted at the Department of Pathology in Krishna Vishva Vidyapeeth’s Krishna Hospi

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Rabeek, Jainulavudeen Mohamed, B. Shanthi, and Mary Chandrika Anton. "Platelet Indices as Indicator of Diabetic Nephropathy among Patients Attending a Tertiary Care Centre in South-India." Journal of Pharmaceutical Research International, December 2, 2021, 169–73. http://dx.doi.org/10.9734/jpri/2021/v33i52b33614.

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Introduction: Diabetes mellitus, a chronic metabolic disease affects various organs of the body on a long-term basis. Studies have been conducted on different aspects of the disease, to understand its complications and to detect them earlier to avoid irreversible damage like nephropathy. Aim: The study aims at comparing platelet indices like Plateletcrit (PCT), Platelet Distribution Width (PDW) and Mean Platelet Volume (MPV), with serum creatinine among diabetes, prediabetes patients and non-diabetes controls, to understand the association of the platelet indices and creatinine, an indic

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Rachmanadi, Muhammad Berian, Muhamad Taufik Ismail, and Vita Yanti Anggraeni. "Relationship between Mean Platelet Volume and Critical Limb Ischemia in Diabetes Mellitus Patients." International Journal of Angiology, April 20, 2021. http://dx.doi.org/10.1055/s-0041-1726468.

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Abstract Background The prevalence of diabetes mellitus continues to increase from year to year. Critical limb ischemia (CLI) is one of the complications of diabetes mellitus with a high mortality rate and requires amputation if not treated properly. Mean platelet volume (MPV) is an indicator of platelet activation and is expected to be a predictor of CLI in diabetes mellitus patients. Aim This article investigates the relationship between MPV and the incidence of CLI in diabetes mellitus patients. Method This case–control study was conducted using the vascular registry of Dr. Sardjito Hospita

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Dr., Chilakala Bhargav Nitin. "Platelet Indices as a Predictive Marker in Type 2 Diabetes Complications: Micro Versus Macro Vascular." October 8, 2024. https://doi.org/10.5281/zenodo.13903148.

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Background: Platelet dysfunction is implicated in the pathogenesis of diabeticcomplications. This study investigated the potential of platelet indices as predictivemarkers for complications in type 2 diabetes mellitus (T2DM). Methods: In thisprospective observational study, 95 T2DM patients were followed for one year. Plateletindices, including Mean Platelet Volume (MPV), Platelet Distribution Width (PDW),and Plateletcrit (PCT), were measured at baseline and every three months. Thedevelopment of microvascular and macrovascular complications was monitored.Results: Significant increases in all p

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Akhalesh, Kumar, Kumar Santosh, and Kumar Singh Pradeep. "An Analytical Cross-Sectional Study Assessing Correlation of MPV with Fasting Blood Glucose, Glycosylated Hemoglobin (Hba1c) and Duration of Diabetes in the Diabetic Patients." 15, no. 11 (2023): 624–28. https://doi.org/10.5281/zenodo.11610747.

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AbstractAim: The aim of the present study was to determine the correlation of MPV with fasting blood glucose,glycosylated hemoglobin (HbA1c) and duration of diabetes in the diabetic patients.Material & Methods: This was a cross-sectional study carried out in Department of Pathology, including 200patients who were already diagnosed to have Type 2 DM and 200 nondiabetic subjects without known coronaryartery disease in between the duration of 12 monthsResults: There were more male as compared to females in both groups. MPV was significantly raised in thediabetic population in comparison to co

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Mirghani, Hyder Osman. "Platelets indices clinical implications in diabetes mellitus: A broader insight." World Journal of Diabetes 16, no. 4 (2025). https://doi.org/10.4239/wjd.v16.i4.100467.

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Platelet indices (PIs) including high mean platelet volume (MPV), plateletcrit (PLC), and platelet distribution width (PLDW) are associated with poor glycemic control. In addition, they can indicate prothrombotic and procoagulation risk among patients with diabetes. PI measurement is cheap, quick and fits healthcare system needs in remote outreaching areas in low-income countries. However, a broader insight into their clinical implications in diabetes is lacking. To achieve a wider understanding, we reviewed PubMed/MEDLINE, Google Scholar and Cochrane Library for relevant articles investigatin

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Swarnkar, Shailja, Zaveri Yash Manishkumar, Patel Dev Manish, and Bushra Khanam. "ASSOCIATION OF GLYCAEMIC CONTROL AND PLATELET INDICES – A CROSS SECTIONAL STUDY." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, June 1, 2025, 48–50. https://doi.org/10.36106/ijsr/3205262.

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Background: Cardiovascular complications account for most deaths in diabetic patients, emphasizing the effect of diabetes on cardiovascular health. Platelet indices like mean platelet volume (MPV) and platelet distribution width (PDW) are being recognised as important markers of imminent cardiovascular risk. Furthermore, diabetic patients often demonstrate platelet hyperreactivity which may add to the prothrombotic risk in diabetic population. A retrospective cross-sectional study was undertaken to evaluate association of Methods: MPV and PDW with adequacy of glycaemic control. Linear associat

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