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Dissertations / Theses on the topic 'Cardiovascular damage'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Stanyer, Lee. "Beta-amyloid/plasma lipoprotein interactions : implications for vascular damage." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270774.

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2

Hedberg, P. (Pirjo). "Advances in routine measurement of cardiac damage and cardiovascular risk markers." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514276388.

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Abstract The development of commercially available assays from the measurement of enzyme activity to mass concentrations of proteins, especially the assays of cardiac troponin I and T, has been the most important innovation in the field of cardiovascular laboratory diagnostics over the decade. The availability of a simple, rapid test using whole blood to facilitate processing and to reduce the turnaround time could improve the management of patients presenting with chest pain. The aim of this study was to evaluate the analytical and clinical performance of a new time-resolved fluorometry-base

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3

Hall, Luke Christian. "The Role Of Thiocyanate In Modulating Tissue Damage In Cardiovascular Disease." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17043.

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Myeloperoxidase (MPO) is an enzyme released by activated neutrophils, monocytes, and some tissue macrophages as part of the inflammatory response at sites of inflammation. Thiocyanate anions (SCN-) are a major and preferred substrate for MPO, with oxidation giving rise to increased concentrations of hypothiocyanous acid (HOSCN) at the expense of hypochlorous acid (HOCl) which is generated from chloride ions. There is considerable evidence that these oxidants contribute to damage at sites of inflammation and contribute to the pathophysiology of cardiovascular diseases. HOSCN is much less reacti

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4

DiPeri, Timothy P. "Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/honors/208.

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Cardiovascular disease (CVD) is the leading cause of death in the United States. Nearly half of the people diagnosed with heart failure (HF) die within 5 years of diagnosis. Brain abnormalities secondary to CVD have been observed in many discrete regions, including the hippocampus. Nearly 25% of patients with CVD also have major depressive disorder (MDD), and hippocampal dysfunction is a characteristic of both diseases. In this study, the hippocampus and an area of the hippocampal formation, the dentate gyrus (DG), were studied in a canine model of HF. Using this canine HF model previously, we

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5

Rarick, Kevin Richard. "Cardiovascular end-organ damage in response to increased blood pressure variability : impact of oxidative stress." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3370.

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Baroreflex sensitivity (BRS) is often reduced in elderly populations and patients with chronic cardiovascular diseases leading to a concomitant rise in blood pressure variability (BPV) that is associated with increased cardiovascular related morbidity and mortality. Thus, there is a need to better understand the mechanisms by which BPV causes cardiovascular end-organ damage. Animal studies using sinoaortic denervation (SAD) to increase BPV have demonstrated pathologic changes in the structure of the heart and blood vessels; however, there is a paucity of data investigating changes in functiona

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6

Vranyac-Tramoundanas, Alexandra, and n/a. "Domoic acid-induced cardiac damage : an in vitro and in vivo investigation." University of Otago. Department of Pharmacology & Toxicology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071012.143651.

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Cardiovascular pathology is seen in both animals and humans after domoic acid intoxication. Whether this damage is direct (i.e., cardiotoxic) or indirect (i.e., CNS/autonomic seizures) is not known. We have previously shown that acute in vitro domoic acid (0.05-0.25[mu]M; 10 min) treatment of isolated cardiac mitochondria compromises mitochondrial FADH and NAD⁺-linked respiratory control and mitochondrial energetics. Domoic acid was shown to traverse and bind the cellular membrane of H9c2 cardiac myoblasts. However it did not compromise cellular viability as assessed using cell quantification

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7

Kuwabara, Yasuhide. "Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage." Kyoto University, 2012. http://hdl.handle.net/2433/157428.

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8

Genoni, Giulia. "Cardiovascular dysfunction and metabolic impairment in pediatric obesity. Markers of damage and effects of a behavioral intervention." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/104065.

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9

GIULIETTI, FEDERICO. "Predictors of moderate and severe obstructive sleep apnea and association of nocturnal oximetry parameters with cardiovascular organ damage." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/295289.

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Introduzione: L’apnea ostruttiva nel sonno (OSA) colpisce quasi un miliardo di persone nel mondo, con prevalenza crescente. La maggior parte del rischio di morbilità e mortalità associato all'OSA è legato ad aumentato rischio di sviluppo e/o progressione di malattie cardiovascolari (CV). Il marker più usato per definire sia gravità di malattia che rischio di danno d'organo è l'indice-apnea-ipopnea (AHI). La ricerca di predittori di OSA è in continuo sviluppo. Lo scopo di questo studio è stato valutare i predittori di malattia di grado moderato e grave in un ampio campione non selezionato di pa

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10

Uys, Aletta Sophia. "Comparing autonomic and cardiovascular responses in African and Caucasian men : the SABPA study / Aletta Sophia Uys." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9851.

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Motivation Hypertension is a pertinent health problem for urban black African men (hereafter referred to as African). Sympathetic hyperactivity and a dominant α-adrenergic response pattern have both been implicated as contributing factors to their poor cardiovascular health. In addition to the deleterious effect of neurogenic hypertension on target organs, sympathetic hyperactivity may promote the accelerated progression of left ventricular hypertrophy and structural vascular disease. Aim The overarching aim of this study is to scrutinize autonomic control of the cardiovascular system in a coh

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11

Merlotti, Guido. "Role of lymphocyte co-stimulation pathways and extracellular vesicles in cardiovascular damage of chronic uremic patients and new therapeutic strategies." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/127932.

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Introduction: Chronic kidney disease (CKD) is characterized by high cardiovascular (CV) risk and the RISCAVID study identified a correlation between CV risk and blood levels of sCD40L in uremia. Moreover, sCD40L correlates with osteoblastic differentiation of vascular smooth muscle cells (VSMC) and endothelial cells (EC) inflammation. In addition, CKD-related extracellular vesicles (EVs) express CD40L and polymethylmethacrylate (PMMA) dialyzer could reduce not only uremic toxins as indoxyl sulfate (IS), but also sCD40L and EVs by adsorption. Aim of the study: 1) identify a sCD40L predictive v

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12

Oudot, Carole. "Modulations des atteintes cardiovasculaires et rénales dans l'insulino-résistance." Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON1T019.

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L'insulino-résistance est une caractéristique majeure du syndrome métabolique dont l'incidence ne cesse d'augmenter dans les pays industrialisés parallèlement à l'épidémie d'obésité. La résistance à l'insuline s'accompagne de diverses atteintes au niveau cardiaque, vasculaire et rénal. L'objectif principal était dans un modèle d'insulino-résistance induite par un excès de fructose chez le rat d'évaluer l'influence de la modulation en sodium (en excès ou en restriction) sur les changements métaboliques cardio-rénaux. D'une part, l'influence d'une restriction sodée concomitante à un régime riche

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13

Barp, Jaqueline. "Avaliação do dano oxidativo e função cardiovascular em diferentes modelos de hiperhomocisteinemia : papel protetor do folato e do estrogênio." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/11795.

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Sabe-se que concentrações elevadas de homocisteína (Hcy) estão associadas com o aumento do risco de doenças cardiovasculares e com o dano celular causado pela formação das espécies ativas de oxigênio (EAO). Sabe-se também que o estrogênio atua como antioxidante não enzimático envolvido na proteção cardiovascular. Foram objetivos deste trabalho avaliar o efeito da homocistinúria sobre parâmetros de estresse oxidativo em tecido cardíaco; e avaliar o efeito da hiperhomocisteinemia (HHcy) sobre parâmetros de estresse oxidativo e hemodinâmicos em ratas com e sem estrogênio. Este trabalho foi divido

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14

TORLASCO, CAMILLA. "EFFECTS OF MEDIUM-TERM, UNSUPERVISED, MILD INTENSITY PHYSICAL TRAINING ON CARDIOVASCULAR REMODELLING AND KNEE JOINT DAMAGE IN YOUNG AND MIDDLE-AGED HEALTHY SEDENTARY INDIVIDUALS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/306603.

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Introduzione. Col progredire dell’età, la capacità dell’organismo di modificare struttura e funzione di organi e apparati in risposta agli stimoli si modifica. Scopo di questo progetto è indagare l’effetto dell’età sul rimodellamento cardiovascolare in risposta all’allenamento aerobico e valutare gli effetti della corsa sulla patologia del ginocchio. Metodi. 237 volontari sani, sedentari, sono stati valutati al basale e dopo 6 mesi di allenamento non supervisionato e il completamento della loro prima maratona, con: 1) risonanza magnetica cardiaca a 1.5T; 2) misurazione non invasiva della press

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15

Yun, Brian Min. "Simulations of pulsatile flow through bileaflet mechanical heart valves using a suspension flow model: to assess blood damage." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/53378.

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Defective or diseased native valves have been replaced by bileaflet mechanical heart valves (BMHVs) for many years. However, severe complications still exist, and thus blood damage that occurs in BMHV flows must be well understood. The aim of this research is to numerically study platelet damage that occurs in BMHV flows. The numerical suspension flow method combines lattice-Boltzmann fluid modeling with the external boundary force method. This method is validated as a general suspension flow solver, and then validated against experimental BMHV flow data. Blood damage is evaluated for a physio

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16

Leuillier, Matthieu. "Rôle de l'activité phosphatase de l'époxyde hydrolase soluble dans la régulation de l'homéostasie métabolique et cardiovasculaire. In vivo inactivation of the phosphatase activity of soluble epoxide hydrolase potentiates brown adispose thermogenesis and protects against cardiovascular damage and remodeling Discovery of the first in vivo active inhibitors of the soluble epoxide hydrolase phosphatase domain Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR150.

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Près de 40 ans après sa découverte initiale en 1972, il a été montré en 2003 que l'époxyde hydrolase soluble (sEH), codée par le gène EPHX2, est une protéine bifonctionnelle qui présente non seulement une activité époxyde hydrolase au niveau de sa partie C-terminale mais également une activité lipidophosphatase sur son domaine N-terminal. En effet, au niveau de sa partie C-terminale, l’activité hydrolase métabolise des époxydes d'acides gras polyinsaturés. Notamment, elle transforme les acides époxyeicosatriénoïques, facteurs vasodilatateurs et anti-inflammatoires biologiquement actifs générés

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17

da, Silva Soares Joao Filipe. "Constitutive modeling for biodegradable polymers for application in endovascular stents." Texas A&M University, 2008. http://hdl.handle.net/1969.1/85939.

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Percutaneous transluminal balloon angioplasty followed by drug-eluting stent implantation has been of great benefit in coronary applications, whereas in peripheral applications, success rates remain low. Analysis of healing patterns in successful deployments shows that six months after implantation the artery has reorganized itself to accommodate the increase in caliber and there is no purpose for the stent to remain, potentially provoking inflammation and foreign body reaction. Thus, a fully biodegradable polymeric stent that fulfills the mission and steps away is of great benefit. Biodegrada

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18

Onobun, Emmanuel. "A Novel Method for Synthesis of Hydroxytyrosol." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3267.

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Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol mak

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19

Syvannarath, Varouna. "Rôle du CD31 dans l'issu des lésions tissulaires cardiovasculaire aigues." Thesis, Sorbonne Paris Cité, 2019. https://theses.md.univ-paris-diderot.fr/SYVANNARATH_Varouna_va2.pdf.

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Le CD31, aussi appelé PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) est une glycoprotéine transmembranaire de 130 kDa comprenant 6 domaines de type « immunoglobuline » dans sa portion extracellulaire et deux motifs « ITIM » (Immunoreceptor Tyrosine based Inhibition Motif, qui recrutent des phosphatases) dans sa queue cytoplasmique. De par sa nature trans-homophile et son expression exclusive et constitutive par les cellules endothéliales, les plaquettes et les leucocytes, le CD31 joue un rôle central dans les mécanismes de régulation des cellules interagissant au niveau de l’interfac

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20

MARTINEZ, FERNANDEZ ALMA ESTEFANIA. "ANALYSIS OF LIPID AND PROTEIN OXIDATION STATUS IN HEART FAILURE PATIENTS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/700135.

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Increasing body of evidence supports that oxidative stress is involved systolic and diastolic myocardial dysfunction in HF. Indeed, it has been well established an association between cardiac remodeling (hypertrophy, apoptosis or contractile dysfunction) and oxidative stress. Hence, the identification, quantification and fully characterization of oxidized biomolecules present in the plasma of HF patients can contribute to understand the mechanisms responsible for disease development but also as biological markers. However, the classic biomarkers of oxidative stress identified in HF do not prov

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21

Balčiūnas, Mindaugas. "Kardiovaskulinių komplikacijų sąsajos su endotelio pažeidimo žymenimis po aortos vainikinių jungčių suformavimo operacijų." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20091109_151340-62166.

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Endotelio funkcijos sutrikimas (disfunkcija) - būklė, apibūdinama padidėjusia adhezijos molekulių ekspresija, padidėjusia prouždegiminių veiksnių ir protrombotinių faktorių sinteze bei sutrikusia kraujagyslių tono reguliacija - yra mirties dėl kardiovaskulinės patologijos, miokardo infarkto bei poreikio revaskuliarizacijos procedūroms išsivystymo rizikos veiksnys. Darbo tikslas buvo nustatyti endotelio pažeidimą atspindinčių žymenų, hs-CRP, sVCAM-1 ir sICAM-1 reikšmę, nuspėjant kardiovaskulines komplikacijas po aortos vainikinių jungčių suformavimo operacijos, atliktos dirbtinės kraujo apytako

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22

Wang, Xiaohui. "Role of TLRs, Hippo-YAP1 Signaling, and microRNAs in Cardiac Repair and Regeneration of Damaged myocardium During Ischemic Injury." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3287.

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Cardiovascular disease is a leading cause of death in the United States. Toll-like receptor (TLR)-mediated pathways have been demonstrated to play a role in myocardial ischemia/reperfusion (I/R) injury. We and others have shown that PI3K/Akt signaling is involved in regulating cellular survival and protecting the myocardium from I/R induced injury. In this dissertation, we provide compelling evidence that miR-125b serves to “fine tune” TLR mediated NF-kB responses by repressing TNF-a and TRAF6 expression. We constructed lentiviral expressing miR-125b, delivered it into the myocardium. The data

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23

Lindsay, Angus John Chisholm. "Acute and chronic individualised psychophysiological stress assessment of elite athletes through non-invasive biochemical analysis." Thesis, University of Canterbury. School of Biological Sciences, 2015. http://hdl.handle.net/10092/10737.

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Intense exercise is known to cause alterations in the psychophysiological status of an athlete. Monitoring the health and recovery of an athlete is imperative for the maintenance of performance and reduced fatigue and injury incidence. The physicality associated with select sports results in significant elevations and suppression of psychophysiological biomarkers that are often modulated by game-related impacts, intense training regimes and psychosocial aspects associated with the professional era. The aim of the studies outlined in this thesis were to determine the effectiveness of selecte

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24

Majane, Olebogeng Harold Isaia. "Impact of excess adiposity on blood pressure and cardiovascular target organ damage." Thesis, 2009. http://hdl.handle.net/10539/7371.

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Ph.D., Faculty of Health Sciences, University of the Witwatersrand, 2009<br>Epidemiological trends suggest that obesity is becoming a major public health problem. Although obesity contributes toward cardiovascular risk by promoting the development of hypertension, dyslipidaemia and diabetes mellitus (conventional risk factors), there is increasing evidence to suggest that excess adiposity may increase risk through effects on cardiovascular target organs that are independent of conventional risk factors. These obesity-induced effects may be produced by mediating damage and dysfunction of

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25

Chen, Yen-Tsun, and 陳彥淳. "Markers of oxidative damage to proteins in health and cardiovascular diseases." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/36898227410689947742.

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26

(9806906), Douglas Jackson. "The use of the ß-blocker Nebivolol and the naturally derived compounds Stevia, Goji berry, and Epicatechin to prevent cardiovascular damage in the DOCA-salt rat model of hypertension." Thesis, 2016. https://figshare.com/articles/thesis/The_use_of_the_-blocker_Nebivolol_and_the_naturally_derived_compounds_Stevia_Goji_berry_and_Epicatechin_to_prevent_cardiovascular_damage_in_the_DOCA-salt_rat_model_of_hypertension/13443056.

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Oxidative stress is a significant factor in the pathogenesis of the DOCA-salt hypertensive rat, producing significantly diminished cardiovascular function. Treatments targeting oxidative stress have been very effective in this model, providing improvements in oxidative stress, cardiac function, vascular function and also remodelling within these tissues. Many plant derived compounds have intrinsic antioxidant properties, and can achieve very significant effects within disease models of oxidative stress. Extracts from the plants Stevia rebaudiana and Lycium barbarum are two compounds that exhib

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27

Barnes, Jill Nicole. "The effects of acute muscle damage and autoimmune disease on vascular function : the potential role of inflammation." 2009. http://hdl.handle.net/2152/6529.

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Inflammation has been implicated in the development of cardiovascular disease and a potential underlying mechanism in the pathogenesis of impaired vascular function. Two different but complementary approaches were utilized to determine the role of inflammation on vascular function. First, to evaluate the effect of acute inflammation, we induced muscle damage to both small and large muscle mass and measured vascular function every 24 hours for up to 5 days of recovery. Eccentric exercise-induced muscle damage, in both small and large muscle mass, resulted in a transient increase in central arte

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28

Pieterse, Chiné. "Leptin : a bi-ethnic approach to unravel its role in cardiovascular disease, the SABPA study / Chiné Pieterse." Thesis, 2015. http://hdl.handle.net/10394/15959.

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Motivation The prevalence of cardiovascular disease is on the increase in sub-Saharan Africa largely owing to lifestyle changes associated with urbanisation. Traditional diets are being replaced with diets high in saturated fat and sugar. In addition to the nutritional transition, urbanisation in developing African countries also contributes to a more sedentary lifestyle. Together these trends contribute to a higher prevalence of obesity and hypertension that are major risk factors for the development of cardiovascular disease. Adipose tissue is now widely recognised as an endocrine organ that

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