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Journal articles on the topic 'Cardiovascular Immune system'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Fernández-Ruiz, Irene. "Immune system and cardiovascular disease." Nature Reviews Cardiology 13, no. 9 (2016): 503. http://dx.doi.org/10.1038/nrcardio.2016.127.

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Annia Ruiz Sánches, Annia Ruiz Sánches, Luis Eugenio Valdés García Luis Eugenio Valdés García, Priscila Soares Dos Santos Priscila Soares Dos Santos, Sandy Sánchez Domínguez Sandy Sánchez Domínguez, and Adolfo Fernández García Adolfo Fernández García. "Dynamics Cardiovascular Diseases Immune System; Mathematical Modeling." International Journal of Engineering and Science Invention 14, no. 1 (2025): 37–43. https://doi.org/10.35629/6734-14013743.

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In this work, investigations were carried out in relation to the cardiovascular system, the main diseases that affected it, the situation that exists worldwide, in the Americas, in Brazil and Cuba in relation to these diseases; in addition, existing statistics regarding mortality due to these diseases in the indicated countries and regions are researched. A model is developed, through a system of differential equations, where it is assumed that the patient has or does not have the presence of thrombi and/or atheromatous plaques; for the case in which there are no disturbances in the process, t

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Napiórkowska-Baran, Katarzyna, Oskar Schmidt, Bartłomiej Szymczak, Jakub Lubański, Agata Doligalska, and Zbigniew Bartuzi. "Molecular Linkage between Immune System Disorders and Atherosclerosis." Current Issues in Molecular Biology 45, no. 11 (2023): 8780–815. http://dx.doi.org/10.3390/cimb45110552.

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A strong relationship exists between immune dysfunction and cardiovascular disease. Immune dysregulation can promote the development of cardiovascular diseases as well as exacerbate their course. The disorders may occur due to the presence of primary immune defects (currently known as inborn errors of immunity) and the more common secondary immune deficiencies. Secondary immune deficiencies can be caused by certain chronic conditions (such as diabetes, chronic kidney disease, obesity, autoimmune diseases, or cancer), nutritional deficiencies (including both lack of nutrients and bioactive non-

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Human, Andrea, Luis Murguia-Favela, Lee Benson, Idan Roifman, and Eyal Grunebaum. "Cardiovascular abnormalities in primary immunodeficiency diseases." LymphoSign Journal 2, no. 3 (2015): 107–34. http://dx.doi.org/10.14785/lpsn-2014-0013.

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In recent years, increasing numbers of patients with primary immune deficiency (PID) are being recognized as also suffering from cardiovascular system (CVS) abnormalities. These CVS defects might be explained by infectious or autoimmune etiologies, as well as by the role of specific genes and the immune system in the development and function of CVS tissues. Here, we provide the first comprehensive review of the clinical, potentially pathogenic mechanisms, and the management of PID, as well as the associated immune and CVS defects. In addition to some well-known associations of PID with CVS abn

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Dal Lin, Carlo, Francesco Tona, and Elena Osto. "The crosstalk between the cardiovascular and the immune system." Vascular Biology 1, no. 1 (2019): H83—H88. http://dx.doi.org/10.1530/vb-19-0023.

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The heart and the immune system are highly integrated systems cross-talking through cytokines, hormones and neurotransmitters. Their balance can be altered by numerous physical or psychological stressors leading to the onset of inflammation, endothelial dysfunction and tissue damage. Here, we review the main players and mechanisms involved in the field. A new research paradigm, which considers also novel contributors, like endothelial cells, is needed to better understand the pathophysiology of immune-mediated cardiovascular disorders and beyond.

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Abboud, François M., and Madhu V. Singh. "Autonomic regulation of the immune system in cardiovascular diseases." Advances in Physiology Education 41, no. 4 (2017): 578–93. http://dx.doi.org/10.1152/advan.00061.2017.

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The autonomic nervous system is a powerful regulator of circulatory adjustments to acute hemodynamic stresses. Here we focus on new concepts that emphasize the chronic influence of the sympathetic and parasympathetic systems on cardiovascular pathology. The autonomic neurohumoral system can dramatically influence morbidity and mortality from cardiovascular disease through newly discovered influences on the innate and adaptive immune systems. Specifically, the end-organ damage in heart failure or hypertension may be worsened or alleviated by pro- or anti-inflammatory pathways of the immune syst

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Green, Chase E., Jessica Chacon, Brandon M. Godinich, et al. "The Heart of the Matter: Immune Checkpoint Inhibitors and Immune-Related Adverse Events on the Cardiovascular System." Cancers 15, no. 24 (2023): 5707. http://dx.doi.org/10.3390/cancers15245707.

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Cancer remains a prominent global cause of mortality, second only to cardiovascular disease. The past decades have witnessed substantial advancements in anti-cancer therapies, resulting in improved outcomes. Among these advancements, immunotherapy has emerged as a promising breakthrough, leveraging the immune system to target and eliminate cancer cells. Despite the remarkable potential of immunotherapy, concerns have arisen regarding associations with adverse cardiovascular events. This review examines the complex interplay between immunotherapy and cardiovascular toxicity and provides an over

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Ravaud, Christophe, Nikita Ved, David G. Jackson, Joaquim Miguel Vieira, and Paul R. Riley. "Lymphatic Clearance of Immune Cells in Cardiovascular Disease." Cells 10, no. 10 (2021): 2594. http://dx.doi.org/10.3390/cells10102594.

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Recent advances in our understanding of the lymphatic system, its function, development, and role in pathophysiology have changed our views on its importance. Historically thought to be solely involved in the transport of tissue fluid, lipids, and immune cells, the lymphatic system displays great heterogeneity and plasticity and is actively involved in immune cell regulation. Interference in any of these processes can be deleterious, both at the developmental and adult level. Preclinical studies into the cardiac lymphatic system have shown that invoking lymphangiogenesis and enhancing immune c

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Abud, Haylim N., and Hiba S. Ahmed. "Fasting Relationship with an Immune System and Heart Disease." Journal for Research in Applied Sciences and Biotechnology 2, no. 6 (2024): 194–204. http://dx.doi.org/10.55544/jrasb.2.6.28.

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One of the most frequent contributors to co-morbidities or death among individuals living with HIV (PLWH) in antiretroviral therapy (ART) is cardiovascular disease (CVD). Vascular cardiovascular disease, arterial disease, stroke, illness, or cardiac cardiac were among the CVDs that over 50% of PLWH are expected to have a greater likelihood of acquiring. The pathological process on such organism varies by shared vulnerabilities, HIV Viral infection itself, or complications of immunosuppressive medication. With this goal, potential non-pharmacological treatments, including dietary practice

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Cheng, Chak Kwong, and Yu Huang. "The gut-cardiovascular connection: new era for cardiovascular therapy." Medical Review 1, no. 1 (2021): 23–46. http://dx.doi.org/10.1515/mr-2021-0002.

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Abstract Our gut microbiome is constituted by trillions of microorganisms including bacteria, archaea and eukaryotic microbes. Nowadays, gut microbiome has been gradually recognized as a new organ system that systemically and biochemically interact with the host. Accumulating evidence suggests that the imbalanced gut microbiome contributes to the dysregulation of immune system and the disruption of cardiovascular homeostasis. Specific microbiome profiles and altered intestinal permeability are often observed in the pathophysiology of cardiovascular diseases. Gut-derived metabolites, toxins, pe

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Yoo, Ji Youn, Sarah Sniffen, Kyle Craig McGill Percy, Veera Bramhachari Pallaval, and Bojjibabu Chidipi. "Gut Dysbiosis and Immune System in Atherosclerotic Cardiovascular Disease (ACVD)." Microorganisms 10, no. 1 (2022): 108. http://dx.doi.org/10.3390/microorganisms10010108.

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Atherosclerosis is a leading cause of cardiovascular disease and mortality worldwide. Alterations in the gut microbiota composition, known as gut dysbiosis, have been shown to contribute to atherosclerotic cardiovascular disease (ACVD) development through several pathways. Disruptions in gut homeostasis are associated with activation of immune processes and systemic inflammation. The gut microbiota produces several metabolic products, such as trimethylamine (TMA), which is used to produce the proatherogenic metabolite trimethylamine-N-oxide (TMAO). Short-chain fatty acids (SCFAs), including ac

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Ren, Hao, Botao Zhu, Yuze An, Feng Xie, Yichuan Wang, and Yurong Tan. "Immune communication between the intestinal microbiota and the cardiovascular system." Immunology Letters 254 (February 2023): 13–20. http://dx.doi.org/10.1016/j.imlet.2023.01.007.

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13

Mohanta, Sarajo K., Ting Sun, Shu Lu, et al. "The Impact of the Nervous System on Arteries and the Heart: The Neuroimmune Cardiovascular Circuit Hypothesis." Cells 12, no. 20 (2023): 2485. http://dx.doi.org/10.3390/cells12202485.

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Three systemic biological systems, i.e., the nervous, the immune, and the cardiovascular systems, form a mutually responsive and forward-acting tissue network to regulate acute and chronic cardiovascular function in health and disease. Two sub-circuits within the cardiovascular system have been described, the artery brain circuit (ABC) and the heart brain circuit (HBC), forming a large cardiovascular brain circuit (CBC). Likewise, the nervous system consists of the peripheral nervous system and the central nervous system with their functional distinct sensory and effector arms. Moreover, the i

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Zoccali, Carmine, and Francesca Mallamaci. "Innate Immunity System in Patients With Cardiovascular and Kidney Disease." Circulation Research 132, no. 8 (2023): 915–32. http://dx.doi.org/10.1161/circresaha.122.321749.

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With a global burden of 844 million, chronic kidney disease (CKD) is now considered a public health priority. Cardiovascular risk is pervasive in this population, and low-grade systemic inflammation is an established driver of adverse cardiovascular outcomes in these patients. Accelerated cellular senescence, gut microbiota-dependent immune activation, posttranslational lipoprotein modifications, neuroimmune interactions, osmotic and nonosmotic sodium accumulation, acute kidney injury, and precipitation of crystals in the kidney and the vascular system all concur in determining the unique seve

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Baik, Alan H., Olalekan O. Oluwole, Douglas B. Johnson, et al. "Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies." Circulation Research 128, no. 11 (2021): 1780–801. http://dx.doi.org/10.1161/circresaha.120.315894.

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Immune-based therapies have revolutionized cancer treatments. Cardiovascular sequelae from these treatments, however, have emerged as critical complications, representing new challenges in cardio-oncology. Immune therapies include a broad range of novel drugs, from antibodies and other biologics, including immune checkpoint inhibitors and bispecific T-cell engagers, to cell-based therapies, such as chimeric-antigen receptor T-cell therapies. The recognition of immunotherapy-associated cardiovascular side effects has also catapulted new research questions revolving around the interactions betwe

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Rajabova, Nilufar Turabayevna. "IMPORTANCE OF IMMUNE SYSTEM IN ISCHAEMIC HEART DISEASE IN WOMEN." SOLUTION OF SOCIAL PROBLEMS IN MANAGEMENT AND ECONOMY 2, no. 7 (2023): 34. https://doi.org/10.5281/zenodo.8013645.

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The adaptive immune response has recently emerged as an important factor in a wide range of cardiovascular diseases, including atherosclerosis, hypertension, cardiac remodelling and heart failure; however, its role is not fully understood. Since the recruitment of innate sensitive cells such as neutrophils and monocytes/macrophages coordinate with adaptive immunity such as T cells, dendritic cells and B cells, the temporal response and descriptions relating to the cellular phenotype and inflammatory processes in general need further research, clarification and consensus, especially in relation

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Shimada, Kazunori. "Immune System and Atherosclerotic Disease." Circulation Journal 73, no. 6 (2009): 994–1001. http://dx.doi.org/10.1253/circj.cj-09-0277.

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Kristen A, Windoloski, Ottesen Johnny T, and Olufsen Mette S. "In Silico modeling of immune-cardiovascular-endocrine interactions." Journal of Cardiovascular Medicine and Cardiology 9, no. 4 (2022): 037–41. http://dx.doi.org/10.17352/2455-2976.000186.

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The immune system provides an intricate, balanced response to combat the effects of inflammatory stimuli. It incorporates both positive and negative feedback from multiple physiological systems such as the cardiovascular and endocrine systems including mechanisms functioning on a variety of time scales. They have been studied individually via scientific experiments and using mathematical modeling. However, more analysis is needed to study the interactions between these three systems during an inflammatory event. We present the first dynamical systems model studying immune, cardiovascular and e

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Schloss, Maximilian J., Filip K. Swirski, and Matthias Nahrendorf. "Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity." Circulation Research 126, no. 9 (2020): 1242–59. http://dx.doi.org/10.1161/circresaha.120.315936.

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Unhealthy diet, lack of exercise, psychosocial stress, and insufficient sleep are increasingly prevalent modifiable risk factors for cardiovascular disease. Accumulating evidence indicates that these risk factors may fuel chronic inflammatory processes that are active in atherosclerosis and lead to myocardial infarction and stroke. In concert with hyperlipidemia, maladaptive immune system activities can contribute to disease progression and increase the probability of adverse events. In this review, we discuss recent insight into how the above modifiable risk factors influence innate immunity.

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Zhao, Tian X., and Ziad Mallat. "Targeting the Immune System in Atherosclerosis." Journal of the American College of Cardiology 73, no. 13 (2019): 1691–706. http://dx.doi.org/10.1016/j.jacc.2018.12.083.

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Fett, James D. "ACEI and ARB may also benefit CHF through immune system modulation (down-regulation of immune system)." International Journal of Cardiology 103, no. 1 (2005): 107. http://dx.doi.org/10.1016/j.ijcard.2004.06.019.

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22

Cai, Jingjing, Meng Xu, Xiaojing Zhang, and Hongliang Li. "Innate Immune Signaling in Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases." Annual Review of Pathology: Mechanisms of Disease 14, no. 1 (2019): 153–84. http://dx.doi.org/10.1146/annurev-pathmechdis-012418-013003.

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The physiological significance of innate immune signaling lies primarily in its role in host defense against invading pathogens. It is becoming increasingly clear that innate immune signaling also modulates the development of metabolic diseases, especially nonalcoholic fatty liver disease and cardiovascular diseases, which are characterized by chronic, low-grade inflammation due to a disarrangement of innate immune signaling. Notably, recent studies indicate that in addition to regulating canonical innate immune-mediated inflammatory responses (or immune-dependent signaling-induced responses),

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23

Reis, Flávio, Leonardo M. R. Ferreira, Eduardo Ortega, and Sofia Viana. "Nutrition and Gut Microbiota–Immune System Interplay in Chronic Diseases." Nutrients 17, no. 8 (2025): 1330. https://doi.org/10.3390/nu17081330.

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Yoo, Ji, Maureen Groer, Samia Dutra, Anujit Sarkar, and Daniel McSkimming. "Gut Microbiota and Immune System Interactions." Microorganisms 8, no. 10 (2020): 1587. http://dx.doi.org/10.3390/microorganisms8101587.

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Dynamic interactions between gut microbiota and a host’s innate and adaptive immune systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut microbiota metabolizes proteins and complex carbohydrates, synthesizes vitamins, and produces an enormous number of metabolic products that can mediate cross-talk between gut epithelium and immune cells. As a defense mechanism, gut epithelial cells produce a mucosal barrier to segregate microbiota from host immune cells and reduce intestinal permeability. An impaired interaction between gut bacteria and the mucosal immu

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Muhammad, Khalid, Mohammed A. Ayoub, and Rabah Iratni. "Vascular Inflammation in Cardiovascular Disease: Is Immune System Protective or Bystander?" Current Pharmaceutical Design 27, no. 18 (2021): 2141–50. http://dx.doi.org/10.2174/1381612827666210118121952.

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Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Chronic atherosclerosis induced vascular inflammation and perturbation of lipid metabolism is believed to be a major cause of CVD. Interplay of innate and adaptive Immune system has been interwined with various risk factors associated with the initiation and progression of atherosclerosis in CVD. A large body of evidence indicates a correlation between immunity and atherosclerosis. Retention of plasma lipoproteins in arterial subendothelial wall triggers the T helper type 1 (Th1) cells and monocyte-derived macrophage

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Xu, Meng, Peter P. Liu, and Hongliang Li. "Innate Immune Signaling and Its Role in Metabolic and Cardiovascular Diseases." Physiological Reviews 99, no. 1 (2019): 893–948. http://dx.doi.org/10.1152/physrev.00065.2017.

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The innate immune system is an evolutionarily conserved system that senses and defends against infection and irritation. Innate immune signaling is a complex cascade that quickly recognizes infectious threats through multiple germline-encoded cell surface or cytoplasmic receptors and transmits signals for the deployment of proper countermeasures through adaptors, kinases, and transcription factors, resulting in the production of cytokines. As the first response of the innate immune system to pathogenic signals, inflammatory responses must be rapid and specific to establish a physical barrier a

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Ekdahl, Kristina N., Inga Soveri, Jöns Hilborn, Bengt Fellström, and Bo Nilsson. "Cardiovascular disease in haemodialysis: role of the intravascular innate immune system." Nature Reviews Nephrology 13, no. 5 (2017): 285–96. http://dx.doi.org/10.1038/nrneph.2017.17.

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Van Laecke, Steven, Thomas Malfait, Eva Schepers, and Wim Van Biesen. "Cardiovascular disease after transplantation: an emerging role of the immune system." Transplant International 31, no. 7 (2018): 689–99. http://dx.doi.org/10.1111/tri.13160.

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Knowlton, Kirk U., and Cornel Badorff. "The Immune System in Viral Myocarditis." Circulation Research 85, no. 6 (1999): 559–61. http://dx.doi.org/10.1161/01.res.85.6.559.

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Maiese, Kenneth, Zhao Zhong Chong, Yan Chen Shang, and Jinling Hou. "FoxO proteins: cunning concepts and considerations for the cardiovascular system." Clinical Science 116, no. 3 (2009): 191–203. http://dx.doi.org/10.1042/cs20080113.

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Dysfunction in the cardiovascular system can lead to the progression of a number of disease entities that can involve cancer, diabetes, cardiac ischaemia, neurodegeneration and immune system dysfunction. In order for new therapeutic avenues to overcome some of the limitations of present clinical treatments for these disorders, future investigations must focus upon novel cellular processes that control cellular development, proliferation, metabolism and inflammation. In this respect, members of the mammalian forkhead transcription factors of the O class (FoxOs) have increasingly become recogniz

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Mitchell, J. A., B. Ryffel, V. F. J. Quesniaux, N. Cartwright, and M. Paul-Clark. "Role of pattern-recognition receptors in cardiovascular health and disease." Biochemical Society Transactions 35, no. 6 (2007): 1449–52. http://dx.doi.org/10.1042/bst0351449.

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A role for PRRs (pattern-recognition receptors) in immune cell function is now well established. In macrophages and other immune cells, activation of TLRs (Toll-like receptors) and cytosolic NLRs [NOD (nucleotide oligomerization domain) proteins containing a leucine-rich repeat] results in the induction of genes and release of imunoregulator hormones including cytokines and NO (nitric oxide). In addition to immune cells, structural cells of the cardiovascular system including endothelial cells, vascular smooth muscle and cardiac myocytes express functional PRRs and sense PAMPs (pathogen-associ

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Scudiero, Olga, Barbara Lombardo, Mariarita Brancaccio, et al. "Exercise, Immune System, Nutrition, Respiratory and Cardiovascular Diseases during COVID-19: A Complex Combination." International Journal of Environmental Research and Public Health 18, no. 3 (2021): 904. http://dx.doi.org/10.3390/ijerph18030904.

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Coronaviruses (CoVs) represent a large family of RNA viruses that can infect different living species, posing a global threat to human health. CoVs can evade the immune response, replicate within the host, and cause a rapid immune compromise culminating in severe acute respiratory syndrome. In humans, the immune system functions are influenced by physical activity, nutrition, and the absence of respiratory or cardiovascular diseases. This review provides an in-depth study between the interactions of the immune system and coronaviruses in the host to defend against CoVs disease.

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Vivekanandan, K. "Current Trends of Immune System Engineering in Healthcare Applications." December 2022 1, no. 1 (2022): 26–37. http://dx.doi.org/10.36548/rrrj.2022.1.003.

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Immune system engineering presents significant challenges as well as great opportunities for biomedical engineers. Human immunity is critical to both health and disease, and immune system activation plays a critical role in disease prevention. The malfunctioning of the human immune system will result in autoimmune disorders, cardiovascular disease, cancer, and other serious diseases. Immune engineering responds to the immune system's complex challenges by targeting a variety of cellular and molecular processes, such as improving antigen presentation, reviving worn-out tumour cells, engineering

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Vivekanandan, K. "Current Trends of Immune System Engineering in Healthcare Applications." December 2022 1, no. 1 (2022): 26–37. http://dx.doi.org/10.36548/rrrj.2023.1.003.

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Immune system engineering presents significant challenges as well as great opportunities for biomedical engineers. Human immunity is critical to both health and disease, and immune system activation plays a critical role in disease prevention. The malfunctioning of the human immune system will result in autoimmune disorders, cardiovascular disease, cancer, and other serious diseases. Immune engineering responds to the immune system's complex challenges by targeting a variety of cellular and molecular processes, such as improving antigen presentation, reviving worn-out tumour cells, engineering

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Sleptsov, A. A. "Cellular heterogeneity and clonal hematopoiesis of immune system cells in atherosclerosis." Russian Journal of Cardiology 27, no. 10 (2022): 5228. http://dx.doi.org/10.15829/1560-4071-2022-5228.

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Recent studies in single cell RNA sequencing have improved understanding of the structure of the immune cell subpopulation in atherosclerosis. With the help of novel technologies, new subpopulations of immune cells involved in atherosclerosis have been identified. In addition, a following relatively common and strong cardiovascular risk factor has emerged: clonal hematopoiesis of indeterminate potential resulting from the accumulation of somatic mutations during life with the appearance of populations of mutant leukocyte clones. Individuals with this condition are at high risk for cardiovascul

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Sekaninova, Nikola, Lucia Bona Olexova, Zuzana Visnovcova, Igor Ondrejka, and Ingrid Tonhajzerova. "Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases." International Journal of Molecular Sciences 21, no. 19 (2020): 7302. http://dx.doi.org/10.3390/ijms21197302.

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Anorexia nervosa represents a severe mental disorder associated with food avoidance and malnutrition. In patients suffering from anorexia nervosa, cardiovascular complications are the main reason leading to morbidity and mortality. However, the origin and pathological mechanisms leading to higher cardiovascular risk in anorexia nervosa are still unclear. In this aspect, the issue of exact pathological mechanisms as well as sensitive biomarkers for detection of anorexia nervosa-linked cardiovascular risk are discussed. Therefore, this review synthesised recent evidence of dysfunction in multipl

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Mohanta, Sarajo K., Changjun Yin, Christian Weber, et al. "Cardiovascular Brain Circuits." Circulation Research 132, no. 11 (2023): 1546–65. http://dx.doi.org/10.1161/circresaha.123.322791.

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The cardiovascular system is hardwired to the brain via multilayered afferent and efferent polysynaptic axonal connections. Two major anatomically and functionally distinct though closely interacting subcircuits within the cardiovascular system have recently been defined: The artery-brain circuit and the heart-brain circuit. However, how the nervous system impacts cardiovascular disease progression remains poorly understood. Here, we review recent findings on the anatomy, structures, and inner workings of the lesser-known artery-brain circuit and the better-established heart-brain circuit. We

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Kuzheleva, E. A., V. A. Fedyunina, and A. A. Garganeeva. "Patterns of immunological reactions in the pathogenesis of chronic heart failure: review." Kardiologiia 61, no. 12 (2021): 94–104. http://dx.doi.org/10.18087/cardio.2021.12.n1598.

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The immune system is essential for maintaining the homeostasis. At present, there is convincing evidence for participation of the immune system in the pathogenesis of cardiovascular pathology, including the final step of cardiovascular continuum, heart failure. Objective difficulties in understanding subtle processes of loss of the normal cardiac structure and function are based on the diversity of pathogenetic factors of development and progression of chronic heart failure (CHF) and the involvement of most organs and body systems. Russian and international scientists actively study issues of

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Del Pinto, Rita, and Claudio Ferri. "Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives." International Journal of Molecular Sciences 19, no. 12 (2018): 3701. http://dx.doi.org/10.3390/ijms19123701.

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Low-grade chronic inflammation is a common denominator in atherogenesis and related diseases. Solid evidence supports the occurrence of an impairment in the innate and adaptive immune system with senescence, favoring the development of acute and chronic age-related diseases. Cardiovascular (CV) diseases (CVD), in particular, are a leading cause of death even at older ages. Inflammation-associated mechanisms that contribute to CVD development include dysregulated redox and metabolic pathways, genetic modifications, and infections/dysbiosis. In this review, we will recapitulate the determinants

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Dahdah, Albert, Robert M. Jaggers, Gopalkrishna Sreejit, et al. "Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk." Cells 11, no. 20 (2022): 3190. http://dx.doi.org/10.3390/cells11203190.

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Smoking is one of the most prominent addictions of the modern world, and one of the leading preventable causes of death worldwide. Although the number of tobacco smokers is believed to be at a historic low, electronic cigarette use has been on a dramatic rise over the past decades. Used as a replacement for cigarette smoking, electronic cigarettes were thought to reduce the negative effects of burning tobacco. Nonetheless, the delivery of nicotine by electronic cigarettes, the most prominent component of cigarette smoke (CS) is still delivering the same negative outcomes, albeit to a lesser ex

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Baik, Alan H., Katy K. Tsai, David Y. Oh, and Mandar A. Aras. "Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors." Clinical Science 135, no. 5 (2021): 703–24. http://dx.doi.org/10.1042/cs20200331.

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Abstract Immunotherapies have greatly expanded the armamentarium of cancer-directed therapies in the past decade, allowing the immune system to recognize and fight cancer. Immune checkpoint inhibitors (ICIs), in particular, have revolutionized cancer treatment and have demonstrated survival benefit in numerous types of cancer. These monoclonal antibodies increase anti-cancer immunity by blocking down-regulators of adaptive immunity, including cytotoxic T lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), and its ligand (PD-L1), resulting in anti-tumor activity. A

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Bonacina, Fabrizia, Angela Pirillo, Alberico L. Catapano, and Giuseppe D. Norata. "HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases." Cells 10, no. 5 (2021): 1061. http://dx.doi.org/10.3390/cells10051061.

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High density lipoproteins (HDL) are heterogeneous particles composed by a vast array of proteins and lipids, mostly recognized for their cardiovascular (CV) protective effects. However, evidences from basic to clinical research have contributed to depict a role of HDL in the modulation of immune-inflammatory response thus paving the road to investigate their involvement in other diseases beyond those related to the CV system. HDL-C levels and HDL composition are indeed altered in patients with autoimmune diseases and usually associated to disease severity. At molecular levels, HDL have been sh

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Yang, Haolin. "An issue that should be considered is the potential toxicity of ICIs to the cardiovascular system." Highlights in Science, Engineering and Technology 74 (December 29, 2023): 1489–93. http://dx.doi.org/10.54097/yg1cqc27.

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An important consideration is the potential cardiovascular toxicity of immune checkpoint inhibitors (ICIs) in cancer therapy, given their increasing popularity and revolutionizing effects on certain treatment regimens. However, ICIs also exhibit unavoidable side effects such as immune-related adverse events (irAEs), which are particularly significant due to their interaction with underlying diseases. This review aims to explore the reported cardiovascular toxicity in patients treated with ICIs, providing insights into potential mechanisms, monitoring methods, and management strategies for the

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Fildes, James E., Steven M. Shaw, Nizar Yonan, and Simon G. Williams. "The Immune System and Chronic Heart Failure." Journal of the American College of Cardiology 53, no. 12 (2009): 1013–20. http://dx.doi.org/10.1016/j.jacc.2008.11.046.

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Bkaily, Ghassan, and Danielle Jacques. "Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases." International Journal of Molecular Sciences 24, no. 3 (2023): 1998. http://dx.doi.org/10.3390/ijms24031998.

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The vascular endothelium plays a vital role during embryogenesis and aging and is a cell monolayer that lines the blood vessels. The immune system recognizes the endothelium as its own. Therefore, an abnormality of the endothelium exposes the tissues to the immune system and provokes inflammation and vascular diseases such as atherosclerosis. Its secretory role allows it to release vasoconstrictors and vasorelaxants as well as cardio-modulatory factors that maintain the proper functioning of the circulatory system. The sealing of the monolayer provided by adhesion molecules plays an important

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Jia, Yunhui, and Yuanyuan Wei. "Modulators of MicroRNA Function in the Immune System." International Journal of Molecular Sciences 21, no. 7 (2020): 2357. http://dx.doi.org/10.3390/ijms21072357.

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MicroRNAs (miRNAs) play a key role in fine-tuning host immune homeostasis and responses through the negative regulation of mRNA stability and translation. The pathways regulated by miRNAs are well characterized, but the precise mechanisms that control the miRNA-mediated regulation of gene expression during immune cell-development and immune responses to invading pathogens are incompletely understood. Context-specific interactions of miRNAs with other RNA species or proteins may modulate the function of a given miRNA. Dysregulation of miRNA function is associated with various human diseases, su

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Master, Samip R., Arelis Robinson, Glenn Morris Mills, and Richard P. Mansour. "Cardiovascular complications of immune checkpoint inhibitor therapy." Journal of Clinical Oncology 37, no. 15_suppl (2019): 2568. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.2568.

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2568 Background: Cardiac toxicity has largely been underestimated toxicity of checkpoint inhibitors. There have been several cases of myocarditis and fatal heart failure reported in patients treated with checkpoint inhibitors. We did a retrospective analysis of data of adverse effects of drugs that has been made available to public by the FDA. Methods: The FDA has made the data on adverse effects of various treatments available to general public through the FDA Adverse Events Reports System (FAERS) public dashboard. We investigated the cardiac toxicities of various immune check point inhibitor

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Duncan, Bruce Bartholow, and Maria Inês Schmidt. "Chronic activation of the innate immune system may underlie the metabolic syndrome." Sao Paulo Medical Journal 119, no. 3 (2001): 122–27. http://dx.doi.org/10.1590/s1516-31802001000300008.

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CONTEXTO: The metabolic syndrome is characterized by a clustering, in free-living populations, of cardiovascular and diabetes risk factors generally linked to insulin resistance, obesity and central obesity. Consonant with the well-established inflammatory pathogenesis of atherosclerotic disease, the metabolic syndrome is now being investigated in relation to its inflammatory nature. OBJETIVO: We present cross-sectional findings demonstrating that markers of inflammation correlate with components of the metabolic syndrome, and prospective findings of the ARIC Study indicating that markers of i

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Nuralieva, N. F., and D. A. Napalkov. "DEPRESSION AND CARDIOVASCULAR DISEASES." Annals of the Russian academy of medical sciences 69, no. 9-10 (2014): 21–26. http://dx.doi.org/10.15690/vramn384.

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Depression is considered to be an independent cardiovascular risk factor and it may worsen the symptoms of already established cardiovascular pathology such as coronary heart disease, chronic heart failure, stroke and hypertension. 3 key psychobiological mechanisms by means of which depression influences cardiovascular system: disbalance in stress response of endocrine system, hyperregulation of autonomic nervous system and immune disorders leading to dysregulation of acute phase proteins and proinflammatory cytokines release. In majority of studies in patients with depression and cardiovascul

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Dolgikh, О. V., I. N. Alikina, and A. V. Shabaldin. "THE EFFECTS OF ALUMINUM EXPOSURE ON IMMUNE STATUS IN CHILDREN WITH FUNCTIONAL CARDIOVASCULAR SYSTEM DISORDERS." Complex Issues of Cardiovascular Diseases 8, no. 3 (2019): 29–35. http://dx.doi.org/10.17802/2306-1278-2019-8-3-29-35.

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Aim To estimate the prevalence of functional cardiovascular system disorders and immunological parameters in children living in the Irkutsk Region, a technogenic region of Southern Siberia.Methods A set of clinical, laboratory and instrumental, statistical and analytical methods were used in the study. Immunological parameters and the presence of functional cardiovascular system disorders were assessed in 63 children aged 5–11 years living in the technogenic region with aluminum exposure. The study group included children (n = 31) with functional changes in the cardiovascular system. Children

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