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1

Luna, Antonio Bayés de. The surface electrocardiography in ischemic heart disease: Clinical and imaging correlations and prognostic implications. Blackwell Pub., 2007.

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2

S, Kapoor Amar, and Singh B. N, eds. Prognosis and risk assessment in cardiovascular disease. Churchill Livingstone, 1993.

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3

Olsson, B., and M. Schlepper. Cardiac Arrhythmias: Diagnosis Prognosis Therapy Proceedings 1st International Rytmonorm-Congress. Springer London, Limited, 2012.

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4

Olsson, B., and M. Schlepper. Cardiac Arrhythmias: Diagnosis Prognosis Therapy Proceedings 1st International Rytmonorm-Congress. Springer, 2011.

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5

Wise, Matt, and Paul Frost. ICU treatment of cardiovascular failure. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0150.

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Cardiovascular failure or shock is best defined as inadequate delivery or utilization of oxygen for cellular metabolic needs. The majority of shock states are characterized by limitations in perfusion rather than extraction of oxygen by tissues. It is important to recognize that ineffectual tissue perfusion may occur in the absence of hypotension and, therefore, a normal blood pressure does not exclude shock. This chapter covers the etiology of shock, as well as symptoms, complications, diagnosis, prognosis, and treatment.
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6

Deanfield, John E. Diurnal Distribution in Cardiovascular Disease: Prognosis and Therapy (Journal : Cardiology, Vol. 85, Supplement 2, 1994). S. Karger AG (Switzerland), 1994.

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7

London, Gerard M. Cardiovascular complications in end-stage renal disease patients. Edited by Jonathan Himmelfarb. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0268.

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Cardiovascular complications are the predominant cause of death in patients with end-stage renal disease (ESRD). The high incidence of cardiovascular complications results from pathology present before ESRD (generalized atherosclerosis, diabetes, hypertension) and an additive effect of multiple factors including haemodynamic overload and metabolic and endocrine abnormalities more or less specific to uraemia or its treatment modalities. These disorders are usually associated and can exacerbate each other. While ischaemic heart disease is a frequent cause of cardiac death, heart failure and sudd
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8

Peritoneal Carcinomatosis : Diagnosis and Treatment (Developments in Cardiovascular Medicine, 167). Springer, 1995.

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9

Sinagra, Gianfranco, Marco Merlo, and Davide Stolfo. Dilated cardiomyopathy: clinical diagnosis and medical management. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0356.

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Dilated cardiomyopathy (DCM) is a relatively rare primary heart muscle disease with genetic or post-inflammatory aetiology that affects relatively young patients with a low-risk co-morbidity profile. Therefore, DCM represents a particular heart failure model with specific characteristics and long-term evolution. The progressively earlier diagnosis derived from systematic familial screening programmes and the current therapeutic strategies have greatly modified the prognosis of DCM with a dramatic reduction of mortality over recent decades. A significant number of DCM patients present an impres
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10

Neiger, Jeffrey S., and Richard G. Trohman. Pathophysiology and management of electrocution. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0349.

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Electrocution is a common source of morbidity and mortality, primarily affecting young children through accidents in the home and adults through occupational exposure. A familiarity with the basic principles of electrical physics helps elucidate the typical injuries sustained following electrical shock. Although death is a frequent result, patients successfully resuscitated following initial cardiopulmonary arrest often have a favourable prognosis. Survivors of electrocution may suffer injuries to a variety of organ systems, including the skin, cardiovascular system, and nervous system, and ar
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11

Rosca, Monica, Sergio Mondillo, and Kim O’Connor. Left atrium. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198726012.003.0022.

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The left atrium (LA) in a close interdependence with the left ventricle plays an essential role in the overall cardiovascular performance. The impact of LA remodelling on prognosis and risk stratification has gathered increasing evidence. With advances in imaging technology, the assessment of LA size and function become more accessible and precise. LA volume provides the most accurate estimate of LA size and superior prognostic information. Accounting for complex geometry and motion, three-dimensional echocardiography emerges as the preferred technique for the assessment of dynamic changes in
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12

Edun, Babatunde, Michelle K. Haas, Christopher Brendemuhl, Jason V. Baker, and Anthony C. Speights. Health Maintenance. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0012.

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The introduction of highly potent antiretroviral agents has transformed HIV from a disease with a once dismal prognosis to a manageable chronic medical condition. The primary care provider as well as the HIV care provider must focus on aspects of preventive medicine that improve the quality of life and life expectancy of the HIV-infected person. Accurate record-keeping is essential, and examples of HIV primary care flow sheets are presented in this chapter. In addition, tuberculosis screening indications and methods are reviewed. Regular preventative dental and gynecological care should be giv
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13

Vinod, Nikhra. COVID-19 and Long Covid: Organs Damage and Dysfunctions, and Implications for Clinical Course. Heighten Science Publications Inc., 2021. http://dx.doi.org/10.29328/ebook1005.

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Like any other infectious disease, the prognosis of COVID-19 is influenced by infecting agent, the SARS-CoV-2 virus load and the extent of organs affliction and damage. COVID-19 having a propensity for multiorgan involvement carries an adverse prognosis during the clinical course as well as later during the post-recovery period persisting as Long Covid. The direct cytopathic effects of SARS-CoV-2 virus and the erratic and hyper-inflammatory response lead to tissue injury in various organs coupled with physiological dysfunctions and complications. In fact, the multi-system manifestations of COV
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14

Ekker, Merel Sanne, and Frank-Erik de Leeuw. Epidemiology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198722366.003.0001.

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Epidemiology can be used to reveal new causes of ischaemic stroke in young adults. Each year, about 2 million patients worldwide suffer a young stroke between the ages of 18 and 49 years. The overall stroke incidence is decreasing; however, an increase in the incidence of young stroke has been witnessed, possibly due to better awareness, new imaging techniques, and the increased prevalence of traditional risk factors already at a young age. Nevertheless, not all young stroke patients have cardiovascular risk factors. The proportion of patients with arterial dissection, cardioembolic stroke, an
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15

Ather, Sameer, Ayman Farag, Vikas Bhatia, and Fadi G. Hage. Role of Imaging in Chronic Kidney Disease. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0017.

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Cardiovascular disease is highly prevalent in patients with chronic kidney disease (CKD) and is the biggest contributor of death in these patients. Myocardial perfusion imaging (MPI) is a validated tool for diagnosing coronary artery disease (CAD) and for predicting short and long term prognosis in this patient population. Non-invasive stress imaging, with MPI or other imaging modalities, is widely used for risk stratification in patients with end-stage renal disease (ESRD) being evaluated for kidney transplantation due to the paucity of donor organs and the high cardiovascular risk of patient
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16

Farmakis, Dimitrios, John Parissis, George Papingiotis, and Gerasimos Filippatos. Acute heart failure. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0051_update_001.

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Acute heart failure is defined as the rapid development or change of symptoms and signs of heart failure that requires urgent medical attention and usually hospitalization. Acute heart failure is the first reason for hospital admission in individuals aged 65 or more and accounts for nearly 70% of the total health care expenditure for heart failure. It is characterized by an adverse prognosis, with an in-hospital mortality rate of 4–7%, a 2–3-month post-discharge mortality of 7–11%, and a 2–3-month readmission rate of 25–30%. The majority of patients have a previous history of heart failure and
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17

Grundy, Seamus. Pleural infection and malignancy. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0143.

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Pleural infection transitions from simple parapneumonic effusion, to complex parapneumonic effusion, to empyema. Primary empyema occurs without an underlying pneumonic process. Pleural infection commonly presents identically to pneumonia with dyspnoea, purulent sputum, and fevers. It may be associated with pleuritic chest pain. Empyema can cause systemic sepsis, leading to cardiovascular instability and multi-organ failure. A malignant pleural effusion arises when malignant cells infiltrate the pleura, resulting in increased production and decreased lymphatic drainage of pleural fluid. Maligna
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18

Farmakis, Dimitrios, John Parissis, and Gerasimos Filippatos. Acute heart failure: epidemiology, classification, and pathophysiology. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0051.

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Acute heart failure is defined as the rapid development or change of symptoms and signs of heart failure that requires urgent medical attention and usually hospitalization. Acute heart failure is the first reason for hospital admission in individuals aged 65 or more and accounts for nearly 70% of the total health care expenditure for heart failure. It is characterized by an adverse prognosis, with an in-hospital mortality rate of 4-7%, a 2-3-month post-discharge mortality of 7-11%, and a 2-3-month readmission rate of 25-30%. The majority of patients have a previous history of heart failure and
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19

Toner, Andrew, Mark Hamilton, and Maurizio Cecconi. Post-surgery, post-anaesthesia complications. Edited by Jonathan G. Hardman. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0047.

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Postoperative complications are common in high-risk surgical populations and are associated with poor short-term and long-term outcomes. Morbidity can be identified using prospective assessment of pathological criteria, or deviations from the ideal postoperative course requiring clinical intervention. While infections are the most prevalent complication type, morbidity affecting the heart, lungs, kidneys, or brain carry the worst prognosis. Specific pathophysiological processes drive morbidity in each organ system. In addition, dysfunction of the cardiovascular and immune systems can lead to m
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20

Lombardi, Massimo, and Antonia Camporeale. Cardiovascular magnetic resonance in less common pathologies. Edited by Dudley Pennell. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0111.

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Contrast-enhanced cardiovascular magnetic resonance plays a pivotal role in diagnostic and prognostic definition of less common pathologies such as Anderson–Fabry disease, cardiac amyloidosis, left ventricular non-compaction, sarcoidosis, and cardiac iron loading.
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21

Dey, Ida Dzifa, and David Isenberg. Systemic lupus erythematosus—management. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0118.

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Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with varied presentation and a disease course characterized by remission and flares. Over the last 50 years, the prognosis of SLE has improved considerably. The introductions of corticosteroids and later of cytotoxic drugs, dialysis, and renal transplantation were the major contributors to this improvement. Nevertheless, the treatment and general management of lupus continues to present a challenge. While lupus may, for some patients, represent a relatively mild set of problems, many others require large doses of immunosuppr
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22

Dey, Ida Dzifa, and David Isenberg. Systemic lupus erythematosus—management. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0118_update_003.

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Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with varied presentation and a disease course characterized by remission and flares. Over the last 50 years the prognosis of SLE has improved considerably. The introductions of corticosteroids and later of cytotoxic drugs, dialysis, and renal transplantation were the major contributors to this improvement. Nevertheless, the treatment and general management of lupus continues to present a challenge. While lupus may, for some patients, represent a relatively mild set of problems, many others require large doses of immunosuppre
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23

Feist, Eugen, and Gerd-R. Burmester. Rheumatoid arthritis—clinical features. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0111.

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Rheumatoid arthritis (RA) presents with variable clinical features, making this most frequent chronic systemic autoimmune disease with characteristic joint involvement a diagnostic and therapeutic challenge. This chapter describes in detail the different clinical, laboratory and imaging findings in patients with RA. In addition to the characteristic arthritic involvement, which can lead to severe joint changes with progressive destruction and loss of function, other systemic disease manifestations as well as an increased risk for cardiovascular events and non-Hodgkin's lymphoma with relevance
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24

Hjalgrim, Henrik, Ellen T. Chang, and Sally L. Glaser. Hodgkin Lymphoma. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0039.

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Hodgkin lymphoma (HL) is a malignant neoplasm of the lymphatic system. The malignant cell clone derives from germinal center B lymphocytes in ~98% of cases, the rest being of T-lymphocyte origin. Each year, HL is diagnosed in roughly 66,000 individuals worldwide. HL is curable with modern therapy in the vast majority of patients, with five-year survival rates exceeding 90% for early-stage disease. However, so far this excellent prognosis has been achieved at the expense of a high incidence of severe long-term treatment complications such as secondary malignancies, and endocrine and cardiovascu
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25

Paul, Richard, Pavlos Myrianthefs, George Baltopoulos, and Shaun McMaster. Blood gas analysis: acid–base, fluid, and electrolyte disorders. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0018.

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Acid-base homeostasis is vital for the maintenance of normal tissue and organ function, as both acidosis and alkalosis can have harmful and potentially life-threatening effects. Arterial blood gas analysis, combined with routine clinical history and examination, can provide useful information for the management of the critically ill cardiac patient. Most acid-base derangements are reversed by treatment of the underlying disease process, rather than simple correction of the abnormal pH, and prognosis is determined by the nature of the underlying disease, rather than the extent of pH value devia
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26

Paul, Richard, and Paul Grant. Blood gas analysis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0018_update_001.

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Acid-base homeostasis is vital for the maintenance of normal tissue and organ function, as both acidosis and alkalosis can have harmful and potentially life-threatening effects. Arterial blood gas analysis, combined with routine clinical history and examination, can provide useful information for the management of the critically ill cardiac patient. Most acid-base derangements are reversed by treatment of the underlying disease process, rather than simple correction of the abnormal pH, and prognosis is determined by the nature of the underlying disease, rather than the extent of pH value devia
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27

Dorbala, Sharmila, and Katarina H. Nelson. Inflammatory and Infiltrative Diseases and Tumors. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0026.

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This chapter highlights some of the novel clinical radionuclide imaging strategies beyond perfusion imaging including inflammatory diseases, infiltrative diseases and tumors. Targeted molecular imaging techniques to evaluate cardiac amyloidosis as well as myocardial and vascular inflammation are addressed. Clinical 18F-FDG imaging of cardiac sarcoidosis, cardiovascular prosthetic valve and device infections, systemic vasculitis, and tumors are discussed in detail. For each of these pathologies, a concise overview of the disease pathophysiology and management pertinent to understanding of imagi
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28

Zhang, Luxia, and Haiyan Wang. Chronic kidney disease in developing countries. Edited by David J. Goldsmith. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0096_update_001.

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The spread of non-communicable diseases (NCDs) is a barrier to the development of goals including reduction of poverty, health equity, economic stability, and human security. NCDs accounted for 61% of the estimated 58 million deaths and 46% of the global burden of diseases worldwide in 2005. Among NCDs, chronic kidney disease (CKD) is of particular significance. It is recognized that the burden of CKD is not only limited to its impact on demands for renal replacement therapy but has equally major impacts on the health of the overall population. For example, it is now well established that amon
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29

Beaulieu, Monica, Catherine Weber, Nadia Zalunardo, and Adeera Levin. Chronic kidney disease long-term outcomes. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0097.

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Chronic kidney disease (CKD) is associated with a variety of outcomes, some of which are directly and indirectly related to kidney disease, but which ultimately impact on patients’ quality of life and long-term outcomes. The events to which people with CKD are exposed ultimately determine their risk and prognosis of both progression to needing renal replacement therapy, or other morbidities and mortalities. The notion of competing risk is important. The five major outcomes of CKD are: progression of CKD, progression to ESRD (either dialysis or transplantation); death; cardiovascular events; in
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30

Jaffe, Allan S. The use of biomarkers for acute cardiovascular disease. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0035.

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Understanding the proper use of biomarkers requires clinicians to appreciate some critical pre-analytic and analytic issues, as well as how to use the markers properly. The bene?ts of such an approach will not only facilitate the care of patients today, but will also prepare clinicians to understand and embrace the new generation of markers that is coming and that will continue to make this area transformational for cardiology. Two fundamental concepts underlie the clinical use of biomarkers: First, biomarkers should always be used in conjunction with all other clinical information. Second, in
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31

Jaffe, Allan S. The use of biomarkers for acute cardiovascular disease. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0035_update_001.

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Understanding the proper use of biomarkers requires clinicians to appreciate some critical pre-analytic and analytic issues, as well as how to use the markers properly. The bene?ts of such an approach will not only facilitate the care of patients today, but will also prepare clinicians to understand and embrace the new generation of markers that is coming and that will continue to make this area transformational for cardiology. Two fundamental concepts underlie the clinical use of biomarkers: First, biomarkers should always be used in conjunction with all other clinical information. Second, in
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32

Jaffe, Allan S. The use of biomarkers for acute cardiovascular disease. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0035_update_002.

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Understanding the proper use of biomarkers requires clinicians to appreciate some critical pre-analytic and analytic issues, as well as how to use the markers properly. The bene?ts of such an approach will not only facilitate the care of patients today, but will also prepare clinicians to understand and embrace the new generation of markers that is coming and that will continue to make this area transformational for cardiology. Two fundamental concepts underlie the clinical use of biomarkers: First, biomarkers should always be used in conjunction with all other clinical information. Second, in
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33

AlJaroudi, Wael. Risk Assessment Before Noncardiac Surgery. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0014.

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Perioperative risk assessment is essential in screening patients before noncardiac surgery. Cardiovascular complications such as fatal and non-fatal myocardial infarction (MI), ventricular arrhythmia, pulmonary edema, and stroke are important in-hospital causes of morbidity and mortality intra and post-operatively. The optimal approach is to identify patients at increased risk so that appropriate testing and therapeutic interventions are undertaken a priori to minimize such risk. The initial preoperative evaluation includes identification of surgery-specific risk, patient exercise functional c
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34

Tombetti, Enrico, and Justin C. Mason. Pathophysiology of vasculitis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0017.

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Vasculitis represents a spectrum of disorders that are often divided on the basis of the predominant vessel size affected into large-, medium- and small-vessel vasculitides. This chapter will focus on the pathogenesis of the anti-neutrophil cytoplasmic antibody (ANCA)-associated medium- and small-vessel vasculitides (AAV), and large-vessel vasculitis, Takayasu arteritis, and giant cell arteritis. Underlying pathogenic mechanisms in vasculitis remain to be fully understood. In particular, the initiating event(s) are not known. A combination of infectious or other environmental triggers on a sus
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35

Electrocardiography in Ischemic Heart Disease: Clinical and Imaging Correlations and Prognostic Implications. Wiley-Blackwell, 2007.

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36

Gielen, Stephan, Alessandro Mezzani, Paola Pontremoli, et al. Physical activity and inactivity. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656653.003.0012.

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In this chapter the current evidence for regular aerobic exercise in primary prevention is discussed and recommendations for exercise interventions in the general population are given. Regular physical exercise is an established therapeutic strategy in a number of cardiovascular diseases and with stable chronic heart failure. In these disease entities moderate-intensity aerobic endurance training is the basis of most training programmes. However, high-intensity interval training is more effective in improving cardiovascular exercise capacity without any measurable additional risks. Resistance
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37

Levy, David. Macrovascular complications, hypertension, and lipids. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198766452.003.0008.

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Premature vascular disease is common in Type 1 diabetes, especially in women and those with long duration. Many studies have identified early vascular involvement, using carotid Doppler and coronary artery calcification. Symptoms of coronary heart disease are often absent or muted, and the best methods for identifying occult coronary heart disease in Type 1 patients are not known. The concept of ideal cardiovascular health is valuable in planning preventive lifestyle and medical interventions. ‘Essential’ hypertension in young Type 1 patients is common, and reflects increased arterial stiffnes
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38

Aguilar-Torres, Río. Assessment of left atrial function. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0010.

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The left atrium (LA) plays an important role in cardiovascular performance, not only as a mechanical contributor, elastic reservoir, and a primer for left ventricular filling, but also as a participant in the regulation of intravascular volume through the production of atrial natriuretic peptide.Although LA diameter in the parasternal long-axis view has been routinely employed, LA volume is a more robust marker for predicting events than LA areas or diameters. The assessment of LA performance based on two-dimensional volumetrics, Doppler evaluation of mitral, pulmonary vein flow, and annular t
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39

Lapostolle, Frédéric, and Stephen W. Borron. Management of digoxin poisoning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0323.

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Despite a gradual decline in the clinical use of digitalis glycosides, digitalis toxicity continues to be responsible for substantial morbidity and mortality, particularly among the elderly. Digitalis poisoning may occur acutely, after intentional overdose, but is more often seen as the result of chronic intoxication among patients receiving digitalis therapy. Clinical findings in chronic digitalis poisoning are often subtle. The astute clinician will enquire about digitalis use in older patients with vague complaints and will not be dissuaded from considering digitalis toxicity in the face of
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40

Phillips, Lawrence M., and Leslee J. Shaw. Cost Effectiveness of Imaging with Nuclear Cardiology. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0032.

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This chapter focuses on the economic data available for cardiovascular (CV) imaging. The total costs of testing are substantively lower than those associated with invasive procedures. There are several ongoing randomized trials, such as the PROMISE trial, that may further add to our evidence base on the cost implications of CV imaging. Data for stress nuclear cardiology supports its utility in terms of a high prognostic accuracy and that this test is economically attractive; notably for patients with a high likelihood of coronary artery disease. Data also supports that this benefit does not on
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41

Thomas, Gregory S., L. Samuel Wann, and Myrvin H. Ellestad, eds. Ellestad's Stress Testing. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190225483.001.0001.

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The 6th edition of the textbook Ellestad’s Stress Testing: Principles and Practice was written for the new and veteran clinician alike performing stress testing. Thoroughly updated, referenced and interspersed with case examples, the book reviews how to get the most out exercise testing, without and with ancillary imaging. In addition to evaluation of ST segment depression, other powerful tools to detect ischemia and forecast the future are reviewed to increase the diagnostic accuracy and prognostic ability of exercise testing. The recognition and significance of exercise induced arrhythmias a
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