Relevant bibliographies by topics / Cardiovascular regulation / Dissertations / Theses
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Dissertations / Theses on the topic 'Cardiovascular regulation'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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1

O'Neill, Mark. "Cardiovascular regulation under physiological stress." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294358.

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2

Tur, Jared. "Cardiovascular regulation by Kvβ1.1 subunit". Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6596.

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Heterologous expression systems such as COS-7 cells have demonstrated the profound effects of KCNAB1-3 or Kvβ1-3 proteins on voltage gated potassium channels (Kv) channels. Indeed, in the presence of these β-subunits transiently expressed Kv channels are often modulated in multiple ways. Kv channel membrane expression is often increased in the presence of β-subunits. In addition, non-inactivating Kv currents suddenly become fast-inactivating and fast-inactivating channels become even faster. While much research has demonstrated the profound effects the β-subunits in particular the Kvβ1 subunit
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3

Ylitalo, A. (Antti). "Cardiovascular autonomic regulation in systemic hypertension." Doctoral thesis, Oulun yliopisto, 1999. http://urn.fi/urn:isbn:9514252128.

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Abstract Neurogenic factors are known to be important in the development of hypertension. Our current knowledge of the role of autonomic nervous system in chronic hypertension is, however, limited. The purpose of the present study was to evaluate the possible abnormalities in heart rate variability (HRV) and baroreflex sensitivity (BRS) in patients with long standing systemic hypertension compared to subjects without evidence of cardiovascular disease. A particular aim was also to examine whether genetic variation in the renin-angiotensin-aldosterone system (RAS) genes have an influence on car
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4

Maa, Ming-Hokng 1977. "Alterations in cardiovascular regulation and function assessed using cardiovascular system identification." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/86525.

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Thesis (S.B. and M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2000.<br>Includes bibliographical references (p. 65-67).<br>by Ming-Hokng Maa.<br>S.B.and M.Eng.
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5

Piira, O. P. (Olli-Pekka). "Effects of emotional excitement on cardiovascular regulation." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526209708.

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Abstract The incidence of adverse cardiovascular events is higher among spectators of exciting sports events, particularly in patients with coronary artery disease (CAD), but the mechanistic link between the events is not known. We assessed the hemodynamic, autonomic function, plasma catecholamines, endothelin-1, interleukin-6, and markers of platelet activation and blood coagulation of enthusiastic male ice hockey spectators with CAD (n=55, 60±9 years) and healthy subjects (n=16, 48±6 years) during Finnish national league ice hockey final play-off matches and on a control day. Blood markers w
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6

DeGrande, Sean Thomas. "Phosphatase regulation in cardiovascular physiology and disease." University of Iowa, 2012. http://ir.uiowa.edu/etd/3443.

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Reversible protein phosphorylation is an essential component of metazoan signaling and cardiovascular physiology. Protein kinase activity is required for regulation of cardiac ion channel and membrane receptor function, metabolism, and transcription, and aberrant kinase function is widely observed across disparate cardiac pathologies. In fact, multiple generations of cardiac therapies (eg. beta-adrenergic receptor blockers) have targeted cardiac kinase regulatory cascades. In contrast, essentially nothing is known regarding the mechanisms that regulate cardiac phosphatase activity at baseline
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7

Keramatipour, Mohammad. "Regulation of cardiovascular cell phenotype by BTEB3." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616239.

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8

Way, Monica A. "Regulation of cardiovascular responses from the infralimbic cortex." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28684.pdf.

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9

Ferro, Albert. "#beta#-adrenoceptor cross-regulation in the human cardiovascular system." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318286.

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10

Mcginley, Jared Joseph. "Lateralized Induction of Cardiovascular Responses: Exploring Asymmetric Autonomic Regulation." Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/32888.

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There is clear evidence that the autonomic nervous system (ANS) is lateralized at both the peripheral as well as the central levels of the nervous system. Both the vagus and the sympathetic ganglia asymmetrically innervate the sino-atrial node and the myocardium of the heart. This lateralization has also been observed in afferent as well as efferent projections to nuclei in the brainstem, hypothalamus, and amygdala. Where laterality has not been as clear is in regions of the frontal lobe dedicated to the regulation of autonomic nervous system responses. This study addressed that issue via
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11

Rees, Daryl David. "The role of nitric oxide in the cardiovascular system." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293301.

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Nitric oxide is generated by the vascular endothelium from L-arginine by a constitutive, Ca2+-dependent, NO synthase. Analogues of L-arginine were characterised as inhibitors of NO synthase to investigate the biological significance of the L-arginine-NO pathway in the vessel wall and its role in the cardiovascular system. These inhibitors attenuate the endothelium-dependent vasorelaxation and hypotension induced by various agents, produce an increase in vascular tone and an increase in blood pressure. This suggests that NO is involved in endothelium-dependent relaxation and its continuous rele
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12

曾紹怡 and Siu-yee Patricia Tsang. "Regulation of cholesterol metabolism in hepatocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969835.

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13

Tsang, Siu-yee Patricia. "Regulation of cholesterol metabolism in hepatocytes." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22032459.

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14

Ansakorpi, H. (Hanna). "Cardiovascular regulation in epilepsy with emphasis on the interictal state." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271343.

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Abstract Epilepsy is associated with changes in autonomic cardioregulatory function. Ictally, autonomic disturbances may be evident with significant changes in heart rate (HR), blood pressure (BP) and respiration. However, interictal dysfunction of autonomic cardiovascular system may be subtle and it may be recognized only by delicate tools designed for that purpose. The aim of this study was to evaluate the function of the cardiovascular autonomic regulatory system in patients with epilepsy. Cardiovascular reflex tests were performed on patients with partial or idiopathic generalized epileps
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15

Claflin, Kristin Elizabeth. "The brain renin-angiotensin system in metabolic and cardiovascular regulation." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2196.

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Leptin acts within the brain to increase resting metabolic rate (RMR) and blood pressure (BP). The renin-angiotensin system (RAS) elicits similar effects in the brain, as reviewed in chapter 1, and it has previously been shown that central angiotensin II type 1 (AT1) receptors are required for leptin-mediated inductions in sympathetic nerve activity to the brown adipose tissue. Thus, we hypothesize that the brain RAS mediates the metabolic effects of leptin. To investigate the interaction between the RAS and leptin, we generated the AT1ALepR-KO mouse which lacks the AT1A receptor in leptin-sen
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16

Padley, James. "Acetylcholine in Central Cardiorespiratory Regulation in Health and Depression." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/10283.

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Circulation and breathing movements that are essential for life are regulated by neurons in the hypothalamus and lower brainstem. Activity of these neurons is regulated by peripheral afferent and higher order inputs that release a diverse array of amino acids, amines and peptides. In this thesis we investigated the role of the neurotransmitter acetylcholine (ACh) and its receptors in regulation of cardiorespiratory homeostasis. Secondly, we determined whether or not genetic disturbances in regulation of acetylcholine receptor sensitivity affect central control of circulation, body temperature
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17

Stenger, Michael Brian. "HUMAN CARDIOVASCULAR RESPONSES TO ARTIFICIAL GRAVITY TRAINING." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/252.

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Human cardiovascular adaptations to microgravity include decreased plasma volume, exercise capacity, baroreflex function as well as decreased orthostatic tolerance upon return to a gravity environment. Several countermeasures have been proposed and tested, although currently none have been developed to prevent post-spaceflight orthostatic intolerance (OI). Artificial gravity (AG) generated by short-radius centrifugation (SRC) has been proposed as a countermeasure to OI as well as other cardiovascular alterations. Methods: Fifteen men and fourteen women underwent three weeks of daily (5 days a
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18

Berry, Narelle Margaret, and narelle berry@unisa edu au. "Acute and long term interventions to assess the adaptability of the cardiovascular responses to orthostatic stress." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070228.123618.

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This thesis comprises of four experiments from which related but independent analyses were undertaken. The interventions employed were designed to investigate the effect of cardiovascular adaptation, both in the short and long term on the cardiovascular responses to orthostatic stress. The first study, described in Chapter 3, tested the hypothesis that the cardiovascular system (CVS) could adapt to repeated orthostatic challenges in a single session. 14 subjects were exposed to ten +75° head-up tilts (HUT) over 70 mins. Each tilt involved a 5 min supine period (SUPINE) followed b
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19

McQuarrie, Emily Pamela. "Mineralocorticoids and sodium in chronic kidney disease - regulation and cardiovascular implications." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3269/.

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Chronic kidney disease is common and associated with an elevated cardiovascular risk, as well as the long-term risk of renal failure. At present, therapeutic approaches to managing chronic kidney disease (CKD) do not fully reverse these risks. This has led to study of the determinants of pathological outcomes in these patients, with the hope of further therapeutic interventions to reduce these risks. Mineralocorticoids, predominantly aldosterone, are produced by the adrenal cortex and have a vital role in maintaining sodium status and blood pressure. However, high levels of aldosterone in huma
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20

Moore, C. "The role of neuronal nicotinic acetylcholine receptors in central cardiovascular regulation." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444883/.

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The central effect of nicotine on cardiovascular regulation has been extensively studied. However, due to its unselective nature for nicotinic acetylcholine receptors (nAChR) the involvement of specific nAChRs at sites in the brain, in central nervous cardiovascular regulation remains unclear. The effects of intracerebroventricular (i.c.v.) and intracisternal (i.e.) injections of the a7 selective agonist, PSAB-OFP, and the a4p2 selective agonist, TC-2559, were investigated on blood pressure (BP), heart rate (HR) and renal sympathetic nerve activity (RSNA) compared with nicotine, in the anaesth
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21

Beck, Allison Leigh. "Hostility and Cardiovascular Regulation: An Investigation of Lateralized Pre-Motor Functions." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/79678.

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Behavioral and physiological correlates of hostility, such as cardiovascular lability and increased risk of cardiovascular disease, are vital when considering the possible health risks associated with high levels of hostility (Henry & Meehan, 1981; Matthew & Haynes, 1986; Johnson, 1990; Heller, 1993; Heilman, Bowers, & Valenstein, 1993; Demaree & Harrison, 1997; Demaree Harrison, & Rhodes, 2000; and Shenal & Harrison, 2001). By examining this issue through a functional cerebral systems approach, one is better able to conceptualize changes that occur when men with extreme hostility levels (e.g.
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22

Mollet, Gina Alice. "Hostility and Negative Emotion: Implications for Verbal Learning and Cardiovascular Regulation." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/33325.

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Hostility is a multidimensional construct that has been extensively studied. It has been shown that hostility affects cognitive (Shimojima et al., 2003), behavioral (Prkachin & Silverman, 2002), visual (Herridge, Mollet, Harrison, & Shenal, in press), somatosensory (Herridge, Harrison, & Demaree, 1997a), auditory (Demaree & Harrison, 1997a), motor (Demaree et al., 2002) and pre-motor functioning (Williamson & Harrison, 2003). In order to extend and integrate the present literature on hostility and the effects of negative emotional state on cognition, the present investigation used a cold press
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23

Myredal, Anna. "Cardiovascular regulation and vascular structure in prehypertension and coronary heart disease /." Göteborg : Dept. of Molecular and Clinical Medicine, Sahlgrenska Academy at the University of Gothenburg, 2009. http://hdl.handle.net/2077/20809.

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24

Wijngaarden, Jan van. "Ace inhibitors and cardiovascular regulation the importance of autocrine and paracrine mechanisms /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1992. http://irs.ub.rug.nl/ppn/298212978.

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25

Everhart, Daniel Erik Jr. "Cerebral Regulation of Cardiovascular Functioning and Fluency among Anxious and Nonanxious Men." Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/30497.

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This experiment investigated lateralized hemispheric regulation of the autonomic nervous system (ANS) among high anxious and nonanxious university undergraduate men using a novel laboratory paradigm. Specifically, this three phase paradigm entailed the administration of a verbal fluency (left frontal) and nonverbal fluency (right frontal) task with or without the threat of a painful stimulus (cold pressor) to high anxious and nonanxious participants. Thus, the cerebrums are hypothesized to be engaged in a dual-task experience requiring the regulation of the ANS and concurrent performance on
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26

Pivovarova, Olga [Verfasser]. "Cardiovascular, inflammatory and circadian aspects of metabolic regulation in humans / Olga Pivovarova." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1149050721/34.

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27

Cellini, Nicola. "The Effects Of Sleep On Autonomic Regulation, Cardiovascular Activity, And Cognitive Processing." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423738.

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Sleep is a cyclical behaviour that occurs every day and we spend a significant portion of our life sleeping. While “why do we sleep” remains an unanswered question, we know that sleep is essential for life. Several aspects of our life are dependent on or strictly related to sleep, from molecular and hormonal levels to high-functional behaviours. The main purpose of the present dissertation is to investigate through five experiments two of the most fundamental aspects of human life, cardiovascular regulation and cognitive function, in relation to different sleep situations such as healthy and
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28

Kakall, Zohra. "Autonomic regulation of medullary neurons following cardiorespiratory, glucoprivic and hypoglycaemic insults." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20798.

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The autonomic nervous system (ANS) consists of two divisions: the sympathetic (SNS) and the parasympathetic (PNS) nervous systems. Signal transduction in the ANS requires integration of sensory afferent information from the periphery, central nervous system and spinal cord. Efferent fibres of presynaptic parasympathetic neurons arise from the brainstem and sacral (‘craniosacral’) levels of the spinal cord. There are 5 cranial nerves (CN) that arise from cell bodies located in the Edinger-Westphal nuclei (CN III), superior salivatory nuclei (CN VII), inferior salivatory nuclei (CN IX) and the
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29

Welser, Jennifer Verena. "Regulation of smooth muscle cell phenotype by the a7ß1 integrin." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3312248.

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30

Sund, M. (Malin). "Type XIII collagen: regulation of cardiovascular development and malignant transformation in transgenic mice." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265572.

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Abstract Type XIII collagen is a type II oriented transmembrane protein with a short intracellular domain, a single transmembrane domain and a large, mostly collagenous extracellular domain. Tissue localization and cell culture studies have implicated that it is involved in cell adhesion. The spatio-temporal expression of type XIII collagen mRNA and protein during murine development is studied here. Type XIII collagen mRNAs were expressed at a constant rate during development, with an increase of expression towards birth. The strongest expression was detected in the central and periphe
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31

Liu, Hanguan. "Expression and regulation of phosphodiesterase 3 and phosphodiesterase 4 in rat cardiovascular tissues." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0007/NQ42955.pdf.

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32

Creasy, Kate Townsend. "ZHX2 REGULATION OF LIPID METABOLISM AND THE BALANCE BETWEEN CARDIOVASCULAR AND HEPATIC HEALTH." UKnowledge, 2015. http://uknowledge.uky.edu/pharmacol_etds/10.

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The growing obesity epidemic in America carries with it numerous health risks, including diabetes, increased serum lipid levels, and excess fat accumulation in the liver. If these conditions persist or become exacerbated, they may lead to the development of cardiovascular disease, the current leading cause of death among Americans, or to nonalcoholic fatty liver disease (NAFLD) which can progress to hepatocellular carcinoma (HCC), one of the deadliest forms of cancer. Better understanding of the genes involved in these diseases can lead to improved identification of at-risk individuals and tre
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33

Sun, Bing, and 孫冰. "Vestibular influence on central cardiovascular regulation in the rat: functional and anatomical aspects." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244774.

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34

Raine, Neil Martin. "Cardiovascular adjustments and blood pressure regulation immediately following dynamic exercise in normotensive men." Thesis, Liverpool John Moores University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388524.

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35

Beda, Alessandro. "Cardiovascular and respiratory responses to psychophysiological tasks : methodological issues for assessing autonomic regulation." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440413.

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36

Rook, William. "The effects of chronic hypoxia in utero on cardiovascular regulation in the offspring." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3040/.

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A common consequence of the complications of pregnancy, such as preeclampsia, is reduced supply of nutrients, including oxygen, to the developing fetus. The consequences for the offspring are wide ranging, but include increased risk of cardiovascular disease. However, the mechanisms by which this occurs are poorly understood. Using a rodent model, this study has examined the regulation of blood vessels, particularly those supplying skeletal muscle, by local, endothelially-derived factors, and by the sympathetic nervous system, in adult rat offspring following chronic hypoxia in utero. The key
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37

Bodkin, Jennifer. "Investigating the role of Transient Receptor Potential Ankyrin One (TRPA1) in cardiovascular regulation." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-role-of-transient-receptor-potential-ankyrin-one-trpa1-in-cardiovascular-regulation(86e661c9-d299-45cd-b3d3-b23fe18f9181).html.

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TRPA1 is a member of the TRP superfamily; localised to neural and non-neuronal sites. TRPA1 is activated endogenously by products of oxidative stress, where its expression on sensory neurones leads to the release of vasoactive neuropeptides. Exogenous agonists of TRPAl, mustard oil and cinnamaldehyde, have been shown to cause concentration-dependent vasorelaxation of blood vessels via a variety of mechanisms. My PhD used TRPA1 WT and KO mice to investigate the potential for TRPA1 to alter peripheral artery tone and the implications of this on systemic blood pressure. I also studied the develop
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38

Shenal, Brian V. "Dynamic Effects of Stress and Hostility: Group Differences in Cardiovascular Regulation and Learning." Diss., Virginia Tech, 2000. http://hdl.handle.net/10919/27464.

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This experiment tested hypotheses linking the right cerebral regulation of hostility and cardiovascular reactivity. First, replication of previous research supporting heightened cardiovascular reactivity (mean arterial pressure, systolic blood pressure, diastolic blood pressure, and heart rate) among high-hostile participants was attempted. Second, dynamic variations in functional cerebral asymmetry in response to pain (cold pressor stressor) and affective verbal learning (positive and negative valenced word lists) were measured. High- and low-hostile participants (n = 64) were identified usi
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Cummins, James B. "Adrenergic and Cholinergic Regulation of Cardiovascular Function in Embryonic Neotropic Cormorants (Phalacrocorax basilianus)." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984219/.

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Investigations of cholinergic and adrenergic tone on heart rate (fH) and mean arterial pressure (Pm) during embryonic development have been conducted on numerous avian species. While these investigations have documented that adrenergic tone, a continuous stimulation, on fH and Pm is vital to embryonic development in the birds studied to date, development of cholinergic tone on fH has been shown to vary even within species. Further, past studies have been bias to focus primarily on precocial species while altricial species remain poorly understood in this context. The goal of this investigation
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40

Littlejohn, Nicole Kathryn. "Tissue-specific roles for the renin-angiotensin system in cardiovascular and metabolic regulation." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2236.

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The renin-angiotensin system (RAS) greatly contributes to energy homeostasis through opposing actions in the brain and adipose. We hypothesize that site- and receptor-specific effects of the RAS may represent a novel therapeutic target for obesity, a concept which is fully reviewed in chapter 1. Transgenic “sRA” mice exhibit brain-specific RAS hyperactivity, and a suppressed circulating RAS presumably secondary to the chronic hypertension exhibited by these animals. In chapter 2, we demonstrated that the hypertension observed with elevated brain RAS is mediated by increased vasopressin signali
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SATHER, TOM MALVIN. "MECHANISMS OF CARDIOVASCULAR ADJUSTMENTS ASSOCIATED WITH PRESYNCOPAL-LIMITED LOWER BODY NEGATIVE PRESSURE TOLERANCE (ORTHOSTASIS)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188096.

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In man, tolerance to an orthostatic stress varies widely. Compensatory cardiovascular responses to orthostatic stressors such as head-up tilt, +Gz acceleration, and lower body negative pressure (LBNP) have been identified. However, physiologic reactions associated with the capacity to withstand a presyncopal- limited orthostatic exposure requires additional clarification. The relationship between maximal oxygen uptake (‘VO₂ max) and presyncopal-limited LBNP tolerance was examined in adult male subjects categorized into high (HAC) and low (LAC) aerobic capacity groups. In addition to similar (N
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Pikkujämsä, S. (Sirkku). "Heart rate variability and baroreflex sensitivity in subjects without heart disease:effects of age, sex and cardiovascular risk factors." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514252276.

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Abstract Healthy subjects show wide interindividual variation in their heart rate behavior, but the factors affecting heart rate dynamics are not well known. This research was undertaken to evaluate heart rate variability (HRV) and baroreflex sensitivity (BRS) in a large random sample of subjects without evidence of heart disease, and to estimate the relation of heart rate behavior to age, sex and cardiovascular risk factors. Short-term HRV was analyzed from 15-minute periods of standardized recording in supine and upright positions using time and frequency domain measures, and BRS wa
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Wood, David Rowe Ding Jiahuan. "Design, optimization, and evaluation of conditionally active gene therapy vectors." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5153.

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Le, Cras Timothy David. "Regulation of the levels of mRNA for the LDL receptor and HMG CoA reductase." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239497.

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Royal, Alice. "The regulation of trafficking and function of KCNQ1 potassium channels by phosphatidylinositol-4,5-bisphosphate." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25940.

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The IKs current constitutes part of the repolarisation reserve in the human myocardium, and whilst it does not play a major role at resting heart rates, it becomes a crucial component of repolarisation in the setting of increased sympathetic tone and high heart rates. The formation of the IKs current requires the KCNQ1 α-subunit and the KCNE1 β-subunit. Mutations in either of these subunits can lead to long QT syndrome types 1 and 5, respectively. Loss-of-function mutations in the IKs channel can reduce the repolarisation reserve and lead to action potential prolongation, predisposing to letha
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Higgins, Dane Allen. "A Neuropsychological Investigation of Sex Differences in Cardiovascular Reactivity to Verbal and Spatial Fluency Tasks: Testing a New Model of Sex Differences in Cardiovascular Regulation and Disease." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/27628.

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One hundred twenty-six right-handed undergraduate men and women underwent physiological measurements of SBP, DBP, and HR before and after verbal and figural fluency tasks, used as stressors. Dynamic and functional cerebral regulation of cardiovascular reactivity was assessed, specifically, the role that the frontal lobes have in regulating SBP, DBP, and HR in men and women. Sex differences in the functional cerebral regulation of these cardiovascular factors were predicted. Hostility was assessed in these participants, using the Cook-Medley Hostility Inventory (6 total groups of 21 particip
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Hunter, Kirsty A. "Studies of the regulation of plasma protein synthesis in man using stable isotopes." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU543871.

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Metabolism of the transport protein albumin is known to be regulated by long-term nutrient status. To assess the short-term response to feeding, studies were performed which measured the rate of albumin synthesis once after an overnight fast and once after one of two feeding regimens consisting of five small hourly meals or one large meal. Albumin synthesis increased by approximately 25% and 31% above the fasting value for the small meals and large meal regimens respectively, thus demonstrating that albumin synthesis is acutely sensitive to nutrient intake. A supplementary animal experiment in
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Rhodes, Robert D. "Frontal Lobe Correlates in Hostile Men: Analysis of Facial Motor Tone and Cardiovascular Regulation." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/37723.

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This experimented proposed to test the relationships between self-reported hostility and both facial muscle tone and cardiovascular functioning. Based on previous research, it was proposed that individuals high in self-reported hostility would show increased cardiovascular reactivity in response to a physical stressor (the cold-pressor task). Additionally, based on the integration of multiple lines of research, it was proposed that individuals with high levels of self-reported hostility would show asymmetric facial tone, with greater muscle activation at the left-hemiface. Results showed in
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Cruickshank, Nicholas Christopher. "The Effects Of Hypothalamic Brain-Derived Neurotrophic Factor On Catecholaminergic Regulation Of Cardiovascular Function." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/804.

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Abstract:
Considerable evidence supports the claim that a hyperactive sympathetic nervous system (SNS) is involved in most cases of human hypertension, and therefore a more thorough understanding of the central regulation of the SNS may help elucidate novel therapeutic options. The PVN is a key region in SNS regulation of blood pressure (BP) and heart rate (HR). Stimulation of the parvocellular PVN neurons has been shown to enhance sympathetic outflow and thereby increase BP. Brain-derived neurotrophic factor (BDNF), a modulator of neuronal activity is upregulated in the paraventricular nucleus of the h
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50

Gunner, David J. L. "Role of gut hormones in the regulation of appetite and modulation of cardiovascular function." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501466.

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