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1

Harris, Michael, Bridget K. Stein, John H. P. Tyman, and Christopher M. Williams. "The Structure of the Colourant/Pigment, Carmine Derived from Carminic Acid." Journal of Chemical Research 2009, no. 7 (July 2009): 407–9. http://dx.doi.org/10.3184/030823409x460768.

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The colourant/pigment carmine synthesised from carminic acid and calcium and aluminium acetates has been examined chemically and spectroscopically to determine its structure. As with alizarin, it appears probable that the material is a tetramer but composed of four carminic acid units with aluminium involved with the 5,6-dioxy groups in five-membered rings and calcium chelated with the 10-carbonyl group of the anthraquinone system.
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2

Sánchez-García, Mario Alberto, Xim Bokhimi, Sergio Velázquez Martínez, and Antonio Esteban Jiménez-González. "Dye-Sensitized Solar Cells Prepared with Mexican Pre-Hispanic Dyes." Journal of Nanotechnology 2018 (June 19, 2018): 1–8. http://dx.doi.org/10.1155/2018/1236878.

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A dye-sensitized solar cell (DSSC) is a photovoltaic device capable of generating electrical power from the absorption of solar radiation. These cells use a SnO2 : F/TiO2/dye heterojunction as the active electrode (working electrode). Active electrodes containing TiO2 in the anatase crystalline phase and synthetic dyes are used to achieve high conversion efficiencies. Synthetic dyes, whether organic or organometallic compounds, have the disadvantage of being expensive. For this reason, many efforts are made worldwide to find natural dyes with lower production costs that can be used in the fabrication of DSSCs. Nocheztli is a natural red dye obtained from the cochineal insect Dactylopius coccus; the dye dates from pre-Hispanic times and contains high levels of carminic acid (CA). Nocheztli has been used in Mexico in textile dyeing from pre-Hispanic times to the present. Carmine is an organometallic dye with two molecules of carminic acid and one atom of aluminum in its structure; it is obtained by the interaction of the carminic acid from Nocheztli with aluminum salts. Carminic acid and carmine molecules contain a carboxyl group in their structure, allowing them to anchor to TiO2, creating a suitable heterojunction to prepare DSSCs. In this study, both dyes are used to sensitize the mesoporous TiO2m semiconductor to prepare DSSCs.
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3

Yoshida, Ayako, Yutaka Takagaki, and Takahiro Nishimune. "Enzyme Immunoassay for Carminic Acid in Foods." Journal of AOAC INTERNATIONAL 78, no. 3 (May 1, 1995): 807–11. http://dx.doi.org/10.1093/jaoac/78.3.807.

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Abstract A competitive enzyme immunoassay (EIA) for carminic acid was investigated. Monoclonal anti-carminic acid antibody was obtained from A/J mice immunized with carminic acid-human immunoglobulin G (IgG) conjugate. Carminic acid was extracted with distilled water from beverage, jelly, candy, pasta sauce, yogurt, or ice cream samples. Ham or fish paste samples were digested with pro-nase, then carminic acid was extracted from samples with sodium hydroxide solution. The extract was diluted more than 10-fold with 1% gelatin in borate buffer solution. Microtiter plates were coated with carminic acid-bovine serum albumin (BSA) conjugate or just BSA. Goat anti-mouse lgG(H+L)-peroxidase complex was used as a second antibody, and 3,3′,5,5′-tetramethylbenzidine was used as a substrate for the peroxidase. The working range for quantitative analysis was 0.3–10 ng/mL, and the detection limit was 0.2 μg/g original sample. Recoveries of carminic acid by this assay were >95% for milk beverage and jelly, and >85% for yogurt and fish paste. Carminic acid was detected in 7 of 26 red-colored commercial food products and ranged from 3.5 to 356 μg/g. This EIA system also responded to the structural analogue of carminic acid, laccaic acid.
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4

Merino, Leonardo, Ulla Edberg, Hakan Tidriks, I. Berndtsson, K. Blomberg, S. Gustavsen, M. Hestdal, et al. "Development and Validation of a Quantitative Method for Determination of Carmine (E120) in Foodstuffs by Liquid Chromatography: NMKL Collaborative Study." Journal of AOAC INTERNATIONAL 80, no. 5 (September 1, 1997): 1044–51. http://dx.doi.org/10.1093/jaoac/80.5.1044.

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Abstract ThimA liquid chromatographic method for quantitative determination of carmine (E120) in different foodstuffs is described. Qualitative and semiquantita- tive methods for analysis of carmine and other related dyes are well established. However, quantitative methods available are based mainly on enzymatic reactions that are time-consuming or specific for analysis of carminic acid in yoghurt. In the method developed and validated here, carminic acid is extracted by boiling the sample with HCI, purified on a solid-phase extraction cartridge, and injected on a Cis analytical column. The method was evaluated by an internal analytical quality control and a collaborative study in which 11 laboratories from the Nordic countries participated. The food samples analyzed were fruit jelly, liqueur, juice, yoghurt, and ice cream. Materials were distributed to participants as uniform level and split level. Validation showed that the proposed method is well suited for quantitative determination of carmine. The detection limit is 0.1 mg/L. The mean relative standard deviation for reproducibility varies from 7.9 to 11.7%. The proposed method is simple and relatively fast compared with previously published methods.
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5

Rakić, Violeta, Milena Miljković, Vojkan Miljković, and Nemanja Stančić. "INFLUENCE OF ADDITIVES ON SPECTROSCOPIC CHARACTERISTICS OF THE CARMINIC ACID." Applied Researches in Technics, Technologies and Education 6, no. 4 (2018): 333–39. http://dx.doi.org/10.15547/artte.2018.04.008.

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Foods must have attractive color, flavor and texture to be acceptable to consumers. Carminic acid (C.I. (1956) 75470; C.I. Natural Red 4; EEC No. E120) is a natural red dye extracted from cochineal, the desiccated bodies of female Dactylopius coccus Costa insects. Carminic acid produce pink shades in candy, confections, chewing gum, concentrated fruit juice, smoked fish, liqueurs and alcoholic cordials, soft drinks, yoghurt, ice cream, tomato ketchup, baked goods, dairy products, jams, jellies, eye shadow, and pill coatings. The impact of the presence of aspartame, citric acid and vitamin C on the spectrophotometric parameters of carminic acid was investigated. These results enabled us to evaluate the possibility of using UV-Vis spectrophotometric method for easily identifying and quantifying carminic acid present in a wide variety of foodstuffs in the presence of additives. It was established that the investigated additives do not affect the position of absorbance maximum of the dye nor cause changes in its intensity. The value of molar absorptivity, ε, at 518 nm was 1265.68 ± 49.90 dm3/mol∙cm. The calculated value is necessary for the quantitative spectrophotometric determination of carminic acid food dye. The FT IR spectra of the dye was also recorded.
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6

Rakić, Violeta, Milena Miljković, Vojkan Miljković, and Nemanja Stančić. "INFLUENCE OF ADDITIVES ON SPECTROSCOPIC CHARACTERISTICS OF THE CARMINIC ACID." International Conference on Technics, Technologies and Education, no. 1 (2018): 224–30. http://dx.doi.org/10.15547/ictte.2018.06.002.

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Foods must have attractive color, flavor and texture to be acceptable to consumers. Carminic acid (C.I. (1956) 75470; C.I. Natural Red 4; EEC No. E120) is a natural red dye extracted from cochineal, the desiccated bodies of female Dactylopius coccus Costa insects. Carminic acid produce pink shades in candy, confections, chewing gum, concentrated fruit juice, smoked fish, liqueurs and alcoholic cordials, soft drinks, yoghurt, ice cream, tomato ketchup, baked goods, dairy products, jams, jellies, eye shadow, and pill coatings. The impact of the presence of aspartame, citric acid and vitamin C on the spectrophotometric parameters of carminic acid was investigated. These results enabled us to evaluate the possibility of using UV-Vis spectrophotometric method for easily identifying and quantifying carminic acid present in a wide variety of foodstuffs in the presence of additives. It was established that the inves­tigated additives do not affect the position of absorbance maximum of the dye nor cause changes in its intensity. The value of molar absorptivity, ε, at 518 nm was 1265.68 ± 49.90 dm3/mol∙cm. The calculated value is necessary for the quantitative spectrophotometric determination of carminic acid food dye. The FT IR spectra of the dye was also recorded.
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7

Jalón, Mercedes, Majesús Peńa, and Julián C. Rivas. "Liquid Chromatographic Determination of Carminic Acid in Yogurt." Journal of AOAC INTERNATIONAL 72, no. 2 (March 1, 1989): 231–34. http://dx.doi.org/10.1093/jaoac/72.2.231.

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Abstract A reverse-phase liquid chromatographic method is described for the determination of carminic acid in yogurt. A C18 column is used with acetonitrile-1.19M formic acid (19 + 81) as mobile phase and diode array detection. Sample preparation includes deproteinization with papain and purification in a polyamide column. The relative standard deviation for repeated determinations of carminic acid in a commercial strawberry-flavored yogurt was 3.0%. Recoveries of carminic acid added to a natural-flavored yogurt ranged from 87.2 to 95.3% with a mean of 90.2%. The method permits measurement of amounts as low as 0.10 mg/kg.
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8

IŞIKVER, Yasemin, and Ali IŞIKVER. "Investigation of Adsorption Isotherm Models for Interaction of P(AAm-ClAETA) and Carminic Acid, and Theoretical Approaches." Cumhuriyet Science Journal 44, no. 3 (August 22, 2023): 510–15. http://dx.doi.org/10.17776/csj.1268752.

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In this study, the adsorption isotherm models for the sorption of carminic acid on P(AAm-ClAETA) hydrogels are explained by experimental and theoretical studies. The crosslinked hydrogels with ethylene glycol dimethacrylate were prepared by radical addition reaction of acrylamide (AAm) and 2-(acryloyloxy)ethyl trimethylammonium chloride (ClAETA) monomers in an aqueous solution. The spectral and morphological analyses of P(AAm-ClAETA) hydrogels were performed by FTIR/ATR and SEM, respectively. The adsorbed amounts of carminic acid on P(AAm-ClAETA) hydrogels were evaluated by Giles, Langmuir, and Freundlich adsorption isotherm models. Langmuir parameters were calculated for the adsorption of the dye on the hydrogels according to the L-type Giles isotherm. In addition, it was determined that its adsorption was appropriate from the RL values calculated for 500 mg L-1 carminic acid concentration. In addition, molecular electrostatic potential (MEP) mapping was performed to predict the reactive sites of P(AAm-ClAETA) hydrogels and carminic acid. The results showed that the theoretical and experimental data of the hydrogels were in agreement with each other. As a result, it can be said that P(AAm-ClAETA) hydrogels are suitable for the removal of anionic dyes such as carminic acid from aqueous solutions.
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9

Bustamante-Brito, Rafael, Arturo Vera-Ponce de León, Mónica Rosenblueth, Julio Martínez-Romero, and Esperanza Martínez-Romero. "Metatranscriptomic Analysis of the Bacterial Symbiont Dactylopiibacterium carminicum from the Carmine Cochineal Dactylopius coccus (Hemiptera: Coccoidea: Dactylopiidae)." Life 9, no. 1 (January 3, 2019): 4. http://dx.doi.org/10.3390/life9010004.

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The scale insect Dactylopius coccus produces high amounts of carminic acid, which has historically been used as a pigment by pre-Hispanic American cultures. Nowadays carmine is found in food, cosmetics, and textiles. Metagenomic approaches revealed that Dactylopius spp. cochineals contain two Wolbachia strains, a betaproteobacterium named Candidatus Dactylopiibacterium carminicum and Spiroplasma, in addition to different fungi. We describe here a transcriptomic analysis indicating that Dactylopiibacterium is metabolically active inside the insect host, and estimate that there are over twice as many Dactylopiibacterium cells in the hemolymph than in the gut, with even fewer in the ovary. Albeit scarce, the transcripts in the ovaries support the presence of Dactylopiibacterium in this tissue and a vertical mode of transmission. In the cochineal, Dactylopiibacterium may catabolize plant polysaccharides, and be active in carbon and nitrogen provisioning through its degradative activity and by fixing nitrogen. In most insects, nitrogen-fixing bacteria are found in the gut, but in this study they are shown to occur in the hemolymph, probably delivering essential amino acids and riboflavin to the host from nitrogen substrates derived from nitrogen fixation.
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10

Allevi, P., M. Anastasia, P. Ciuffreda, A. Fiecchi, and A. Scala. "Simple transformation of carminic acid into kermesic acid." Journal of Organic Chemistry 52, no. 24 (November 1987): 5469–72. http://dx.doi.org/10.1021/jo00233a033.

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11

Nanqiang, Li, and Min Jing. "A POLAROGRAPHIC STUDY OF CARMINIC ACID." Acta Physico-Chimica Sinica 2, no. 06 (1986): 549–53. http://dx.doi.org/10.3866/pku.whxb19860611.

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12

Fain, V. Ya, B. E. Zaitsev, and M. A. Ryabov. "Tautomerism and ionization of carminic acid." Russian Journal of General Chemistry 77, no. 10 (October 2007): 1769–74. http://dx.doi.org/10.1134/s1070363207100179.

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13

Nakayama, Norihisa, Yutaka Ohtsu, Daisuke Maezawa-Kase, and Ken-Ichi Sano. "Development of a Rapid and Simple Method for Detection of Protein Contaminants in Carmine." International Journal of Analytical Chemistry 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/748056.

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Protein contaminants in carmine can cause dyspnea and anaphylactic reactions in users and consumers of products containing this pigment. The method generally used for detection of proteins in carmine has low reproducibility and is time-consuming. In this study, a rapid, simple, and highly reproducible method was developed for the detection of protein contaminants in carmine. This method incorporates acidic protein denaturation conditions and ultrafiltration. To prevent protein aggregation, sodium dodecyl sulfate containing gel electrophoresis running buffer was used for dispersing the carmine before filtration. An ultrafiltration device was used to separate the protein contaminants from carminic acid in the carmine solution. Two ultrafiltration devices were compared, and a cylindrical device containing a modified polyethersulfone membrane gave the best results. The method had high reproducibility.
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14

Dapson, Rw. "A method for determining identity and relative purity of carmine, carminic acid and aminocarminic acid." Biotechnic & Histochemistry 80, no. 5-6 (January 2005): 201–5. http://dx.doi.org/10.1080/10520290500485781.

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15

Gabrielli, Luca, Davide Origgi, Giuseppe Zampella, Luca Bertini, Simone Bonetti, Gianfranco Vaccaro, Francesco Meinardi, Roberto Simonutti, and Laura Cipolla. "Towards hydrophobic carminic acid derivatives and their incorporation in polyacrylates." Royal Society Open Science 5, no. 7 (July 2018): 172399. http://dx.doi.org/10.1098/rsos.172399.

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Carminic acid, a natural hydrophilic dye extensively used in the food and cosmetic industries, is converted in hydrophobic dyes by acetylation or pivaloylation. These derivatives are successfully used as biocolourants for rubber objects. In this paper, spectroscopic properties of the carminic acid derivatives in dimethyl sulfoxide and in polybutylacrylate are studied by means of photoluminescence and time-resolved photoluminescence decays, revealing a hypsochromic effect due to the presence of bulky substituents as the acetyl or pivaloyl groups. Molecular mechanics and density functional theory calculations confirm the disruption of planarity between the sugar ring and the anthraquinoid system determined by the esterification.
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16

Fain, V. Ya, B. E. Zaitsev, and M. A. Ryabov. "Tautomerism of metal complexes with carminic acid." Russian Journal of Coordination Chemistry 34, no. 4 (April 2008): 310–14. http://dx.doi.org/10.1134/s1070328408040118.

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17

Kaur, Preeti, and V. K. Gupta. "Spectrophotometric determination of beryllium with carminic acid." Fresenius' Zeitschrift für analytische Chemie 334, no. 5 (January 1989): 447–49. http://dx.doi.org/10.1007/bf00469469.

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18

Allevi, Pietro, Mario Anastasia, Pierangela Ciuffreda, Alberto Fiecchi, Antonio Scala, Steve Bingham, Max Muir, and John Tyman. "The first total synthesis of carminic acid." Journal of the Chemical Society, Chemical Communications, no. 18 (1991): 1319. http://dx.doi.org/10.1039/c39910001319.

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19

Rasmussen, Silas A., Kenneth T. Kongstad, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Majse Nafisi, Alex Van Dam, Mads Bennedsen, et al. "On the biosynthetic origin of carminic acid." Insect Biochemistry and Molecular Biology 96 (May 2018): 51–61. http://dx.doi.org/10.1016/j.ibmb.2018.03.002.

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20

de Souza Gil, Eric, Severino Carlos B. de Oliveira, and Ana Maria de Oliveira-Brett. "Hydroxyanthraquinones Carminic Acid and Chrysazin Anodic Oxidation." Electroanalysis 24, no. 11 (October 23, 2012): 2079–84. http://dx.doi.org/10.1002/elan.201200433.

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21

Katelakha, Kasinee, Acharee Suksuwan, Najwa Yanya Santiworakun Santiworakun, Nureesun Mahamad Mahamad, Winai Dahlan, Vanida Nopponpunth, and Wanida Laiwattanapaisal. "Exploration of The Selective Binding Property of The MIP-grafted Paper for Cochineal Dye." Proceedings of The International Halal Science and Technology Conference 14, no. 1 (March 10, 2022): 1–11. http://dx.doi.org/10.31098/ihsatec.v14i1.480.

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A molecularly imprinted polymer (MIP) is a synthetic polymer that provides specific cavities for its analyte. In this study, the MIP specific to carminic acid, an insect-derived pigment, has been synthesized using methacrylic acid (MAA) and 4-vinyl pyridine (4Vpy) as monomers and ethylene glycol dimethacrylate (EDGMA) as a cross-linker. The imprinted surface particles were characterized by Scanning Electron Microscope (SEM). The rough surface of the synthesized MIP represented the specific binding site for carminic acid. The paper-based MIP polymerization was performed by pre-treatment the cellulose paper with aminopropyltriethoxysilane (APTES) before polymerization with the MIP solution. The novel membrane-grafted MIP exhibits good performance for selective recognition with the target carminic acid, which can be demonstrated by the imprinted factor of 1.94 as compared to those of nonimprinted polymer. According to the Scatchard analysis, it was estimated that there are two types of binding strategy, including high and low affinity, which corresponded to the Ka of 1.24x103 mM and 0.10 x103 mM, respectively. It was thus preliminary concluded that the membrane-grafted MIP fabricated in this study has the potential to be implemented in many applications such as extraction and pre-concentration.
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22

Zucchelli, Margherita, Fernando D. Villarruel, Pedro David-Gara, Mariana R. Costante, Marcos Tascon, Fernando Marte, Fernando S. García Einschlag, and Franco M. Cabrerizo. "Photophysics and photochemistry of carminic acid and related natural pigments." Physical Chemistry Chemical Physics 22, no. 17 (2020): 9534–42. http://dx.doi.org/10.1039/d0cp01312a.

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23

AKCAY, Guven. "Investigation of the Dose-Dependent Effect of Carminic Acid on Brain and Peripheral Tissues." Annals of Medical Research 30, no. 2 (2023): 1. http://dx.doi.org/10.5455/annalsmedres.2022.12.360.

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In recent years, there has been an increase in the frequency of use of food additives and colorants to extend the life of food and to color it. Excessive consumption of these additives can lead to attention deficit hyperactivity disorder and learning disorder, especially in children. Uncontrolled additives whose dosage is not specified can cause an allergic reaction, cause damage to the neurological system and cause cancer. There are not many studies showing the dose-dependent effect of carminic acid. It was aimed to determine the dose-dependent changes of carminic acid, a food additive, in liver, kidney, blood and brain tissues (hippocampus, brain, brain stem) and to investigate the effects of these doses on hyperactivity behaviorally. In our study, dose-dependent effects of 500 mg, 1500 mg and 3000 mg carminic acid (CA) used as a colorant in hippocampus, brain, brain stem, liver, kidney and blood samples were investigated. 32 Wistar albino male rats weighing 150-200 g were divided into 4 groups as control, CA-500, CA-1500 and CA-3000. The locomotor activities of the rats were evaluated in the open field test, and their anxiety behaviors were evaluated in the elevated plus maze test. Carminic acid levels in hippocampus, brain, brain stem, liver, kidney and blood were measured by high performance liquid chromatography (HPLC) method. Locomotor activity and anxiety behavior test results of CA-1500 and CA-3000 groups were increased compared to the control group. In the results of HPLC analysis, 500 mg, 1500 mg and 3000 mg doses administered to rats were not detectable in hippocampus, brain and brain stem tissues, while a dose-dependent increase was found in liver, kidney and blood samples (p<0.5). It was concluded that since carminic acid could not cross the blood-brain barrier, it was not detected in hippocampus, brain and brain stem tissues, and increased dose-dependently in peripheral tissues such as liver, kidney and blood. Although it cannot be detected in the brain, it has been observed that hyperactivity, which may increase locomotor activity and anxiety, may lead to behavioral changes.
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Aragon-Martinez, Othoniel H., Flavio Martinez-Morales, Marco M. González-Chávez, Santiago de J. Méndez-Gallegos, Rodolfo González-Chávez, Juan C. Posadas-Hurtado, and Mario A. Isiordia-Espinoza. "Dactylopius opuntiae [Cockerell] Could Be a Source of Antioxidants for the Preservation of Beef Patties." Insects 14, no. 10 (October 13, 2023): 811. http://dx.doi.org/10.3390/insects14100811.

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Dactylopius opuntiae is an insect pest that contains at least carminic acid, which has antioxidant properties. Since there is a relationship between the antioxidant ability and preservative action of compounds applied to meat products, the purpose of this study was to evaluate the antioxidant activity and usefulness of a D. opuntiae extract for beef patty preservation. The insects were bred and processed to obtain a liquid extract. For the extract, its carminic acid content, antioxidant activity against two free radicals, and actions on food quality parameters were determined. The D. opuntiae dry powder contained 2.91% w/w carminic acid, while the liquid extract exhibited an IC50 value of 3437.8 ± 67.8 and 19633.0 ± 674.5 µg/mL against the DPPH and ABTS radicals. Nevertheless, these antioxidant actions were lower than those found in a D. coccus extract. The D. opuntiae extract improved in a short time the redness and yellowness, eliminated the unfavorable effect of their vehicle on the MetMb level, and greatly reduced the TBARS formation. For the first time, an extract of D. opuntiae was applied to beef patties, and its beneficial antioxidant action on meat acceptance parameters was confirmed, which has potential commercial applications.
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Tao, Yun-Feng, Yu-Juan He, Jin-Zhi Ye, Xiao Yang, Ying-Ying Yang, Ge-Ge Xie, Lan-Xiang Liu, Guan-Ben Du, Hong Zhang, and Bei Zhou. "Cochineal quinone carbon dot synthesis via a keto–enol tautomerism strategy and their intermolecular photo-induced cross-redox interactions with tetracycline." New Journal of Chemistry 45, no. 34 (2021): 15336–43. http://dx.doi.org/10.1039/d1nj02701h.

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26

Masár, Marián, Jasna Hradski, Eva Vargová, Adriána Miškovčíková, Peter Božek, Juraj Ševčík, and Roman Szucs. "Determination of Carminic Acid in Foodstuffs and Pharmaceuticals by Microchip Electrophoresis with Photometric Detection." Separations 7, no. 4 (December 13, 2020): 72. http://dx.doi.org/10.3390/separations7040072.

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This paper presents a novel miniaturized analytical method for the determination of carminic acid, a natural red food dye, in complex food and pharmaceutical matrices by microchip electrophoresis (MCE) with photometric detection. MCE has become a very attractive microscale separation technique because it offers high-speed, high-throughput, small sample injection volume and low reagents consumption. Fast determination of carminic acid in less than 5 min was achieved on a poly(methyl methacrylate) microchip in anionic separation mode at pH 6. Photometric detector based on light-emitting diode technology was set to a wavelength of 490 nm. Using a sample injection volume of 900 nL, a limit of detection of 69 nmol L−1 was achieved. A wide linear dynamic range over four orders of magnitude (from nmol L−1 to mmol L−1) was observed for peak area. Developed method provided favorable intra- and inter-day repeatability of the migration time (up to 2.5% RSD), as well as the repeatability of the peak area (less than 1.9% RSD), regardless of the sample type. The content of carminic acid was determined in various foodstuffs and pharmaceuticals, such as candies, saffron, non-alcoholic drink, and sore throat lozenges with good recoveries (92.5–104.0%).
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Arriagada, Francisco, Catalina Ugarte, Germán Günther, María Angélica Larraín, Víctor Guarnizo-Herrero, Santi Nonell, and Javier Morales. "Carminic Acid Linked to Silica Nanoparticles as Pigment/Antioxidant Bifunctional Excipient for Pharmaceutical Emulsions." Pharmaceutics 12, no. 4 (April 19, 2020): 376. http://dx.doi.org/10.3390/pharmaceutics12040376.

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The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant capacity of the materials, has been of great interest to the pharmaceutical, chemical and food industries. The aim of this work was to prepare and characterize a bifunctional pigment–antioxidant nanomaterial-based carminic acid-decorated solid core-mesoporous shell silica nanoparticles, evaluating its properties as a pigment, its antioxidant capacity and its properties as a chemical stabilizer of emulsions. The chemical stability of oil-in-water (O/W) Pickering emulsions was evaluated determining the stability of vitamin E solubilized in the oil phase. Carminic acid was attached through the action of coupling ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) agents, and the resulting spherical and homogeneous nanoparticles showed a diameter close to 175 nm. A notorious change of emulsion color was observed by the addition of the nanomaterial. Emulsions showed an attractive pink color, and when the pH was adjusted to pH 3 and pH 9, a change in color was observed, analogous to carminic acid in solution. The nanomaterial incorporation also improved chemical stability, decreasing vitamin E consumption to 9.26% of the initial value, demonstrating an important antioxidant effect of the developed nanomaterial.
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28

Floquet, Cedric F. A., Thomas Lindvig, Vincent J. Sieben, Bruce A. MacKay, and Farshid Mostowfi. "Rapid determination of boron in oilfield water using a microfluidic instrument." Analytical Methods 9, no. 12 (2017): 1948–55. http://dx.doi.org/10.1039/c6ay03319a.

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29

Comanici, Radu, Bianca Gabel, Thomas Gustavsson, Dimitra Markovitsi, Christian Cornaggia, Stanislas Pommeret, Catalin Rusu, and Carola Kryschi. "Femtosecond spectroscopic study of carminic acid–DNA interactions." Chemical Physics 325, no. 2-3 (June 2006): 509–18. http://dx.doi.org/10.1016/j.chemphys.2006.01.026.

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Akkapinyo, Chutimon, Kittitat Subannajui, Yingyot Poo-arporn, and Rungtiva P. Poo-arporn. "Disposable Electrochemical Sensor for Food Colorants Detection by Reduced Graphene Oxide and Methionine Film Modified Screen Printed Carbon Electrode." Molecules 26, no. 8 (April 16, 2021): 2312. http://dx.doi.org/10.3390/molecules26082312.

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A facile synthesis of reduced graphene oxide (rGO) and methionine film modified screen printed carbon electrode (rGO-methionine/SPCE) was proposed as a disposable sensor for determination of food colorants including amaranth, tartrazine, sunset yellow, and carminic acid. The fabrication process can be achieved in only 2 steps including drop-casting of rGO and electropolymerization of poly(L-methionine) film on SPCE. Surface morphology of modified electrode was studied by scanning electron microscopy (SEM). This work showed a successfully developed novel disposable sensor for detection of all 4 dyes as food colorants. The electrochemical behavior of all 4 food colorants were investigated on modified electrodes. The rGO-methionine/SPCE significantly enhanced catalytic activity of all 4 dyes. The pH value and accumulation time were optimized to obtain optimal condition of each colorant. Differential pulse voltammetry (DPV) was used for determination, and two linear detection ranges were observed for each dye. Linear detection ranges were found from 1 to 10 and 10 to 100 µM for amaranth, 1 to 10 and 10 to 85 µM for tartrazine, 1 to 10 and 10 to 50 µM for sunset yellow, and 1 to 20 and 20 to 60 µM for carminic acid. The limit of detection (LOD) was calculated at 57, 41, 48, and 36 nM for amaranth, tartrazine, sunset yellow, and carminic acid, respectively. In addition, the modified sensor also demonstrated high tolerance to interference substances, good repeatability, and high performance for real sample analysis.
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Yang, Dongsoo, Woo Dae Jang, and Sang Yup Lee. "Production of Carminic Acid by Metabolically Engineered Escherichia coli." Journal of the American Chemical Society 143, no. 14 (April 2, 2021): 5364–77. http://dx.doi.org/10.1021/jacs.0c12406.

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Atun, G., and G. Hisarli. "Adsorption of carminic acid, a dye onto glass powder." Chemical Engineering Journal 95, no. 1-3 (September 2003): 241–49. http://dx.doi.org/10.1016/s1385-8947(03)00110-4.

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Göktürk, Sinem. "Effect of hydrophobicity on micellar binding of carminic acid." Journal of Photochemistry and Photobiology A: Chemistry 169, no. 2 (January 2005): 115–21. http://dx.doi.org/10.1016/j.jphotochem.2004.06.009.

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34

Allevi, Pietro, Mario Anastasia, Steve Bingham, Pierangela Ciuffreda, Alberto Fiecchi, Giuliana Cighetti, Max Muir, Antonio Scala, and John Tyman. "Synthesis of carminic acid, the colourant principle of cochineal." Journal of the Chemical Society, Perkin Transactions 1, no. 3 (1998): 575–82. http://dx.doi.org/10.1039/a705145j.

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Zhang, Qian, Xinglong Wang, Weizhu Zeng, Sha Xu, Dong Li, Shiqin Yu, and Jingwen Zhou. "De novo biosynthesis of carminic acid in Saccharomyces cerevisiae." Metabolic Engineering 76 (March 2023): 50–62. http://dx.doi.org/10.1016/j.ymben.2023.01.005.

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36

Atwa, Manal. "QUANTITIVE DETERMINATION OF COCHINEAL EXTRACT (Adctylopius coccus),CARMINE,CARMINIC ACID AND 4-AMINOCARMINIC ACID ( E120) IN SOME FOOD- STUFFS." Journal of Agricultural Chemistry and Biotechnology 6, no. 6 (June 1, 2015): 177–90. http://dx.doi.org/10.21608/jacb.2015.48399.

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37

Pinto, Catarina, and J. Sérgio Seixas de Melo. "The molecules of color in Portuguese postage stamps (1857–1909)." Pure and Applied Chemistry 90, no. 3 (February 23, 2018): 435–45. http://dx.doi.org/10.1515/pac-2017-0701.

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AbstractThe nature of the pigments or dyes used to dye the first Portuguese postage stamps has remained unknown until now. In this work, a study has been made of the inks used for red, rose, purple and orange colors in a selected number of Portuguese postage stamps from the period 1857 to 1909. This is based on analysis involving a variety of techniques (X-ray fluorescence, UV-Vis spectroscopy, HPLC-MS/HPLC-DAD, steady and time resolved fluorescence). It was found that the inks included, among others, the inorganic pigments cinnabar (HgS), lead oxide (Pb3O4) and chromate (PbCrO4), lead sulphide (PbS), and the organic compounds carminic acid and Eosin Y. The study demonstrated a non-destructive analysis method for identification of two molecules of color involving the UV-Vis (for carminic acid and Eosin Y) and fluorescence spectra, together with quantum yields and lifetimes (for Eosin Y).
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38

Sun, Wei, Yunying Han, and Kui Jiao. "Voltammetric albumin quantification based on its interaction with carminic acid." Journal of the Serbian Chemical Society 71, no. 4 (2006): 385–96. http://dx.doi.org/10.2298/jsc0604385s.

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In a weak acidic Britton-Robinson (B-R) buffer of pH 4.0, human serum albumin (HSA) can react rapidly with carminic acid (CAA) to form a supramolecular complex. Microelectrostatic fields in the molecular structure of HSA cause the electrostatic binding reaction of the positively charged CAA with the negatively charged HSA. CAA has a sensitive, second order derivative linear sweep voltammetric reductive peak at - 0.54 V (vs. SCE) on a dropping mercury electrode (DME). After the addition of HSA to a CAA solution, the reductive peak current of CAA decreased without a shift of the peak potential. Based on the decrease of the peak current, a sensitive voltammetric method for the determination of microamounts of the protein is proposed. The conditions for the binding reaction and the voltammetric detection were optimized. Under the optimal conditions, the decrease of the voltammetric detection were optimized. Under the optimal conditions, the decrease of the voltammetric peak current was in proportion to the quantity of HSA in the range of 2.0 to 70.0 mg l-1, with a linear regression equation ?Ip"(nA)=11.74 C (mg l-1)-12.33 and a detection limit of 2.0 mg l-1 (3?). The method was further applied to the detection of different kinds of proteins, such as bovine serum albumin (BSA), oval albunim (OVA), lipase, etc. The established method was further applied to the determination of the albumin content in human serum samples and the results obtained by this method were in good agreement with the traditional Coomassie Brilliant Blue G-250 (CBB G-250) spectrophotometric method. The binding mechanism is discussed and the binding ratio was calculated from the voltammetric data.
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Gutteridge, John M. C., and Gregory J. Quinlan. "Carminic acid‐promoted oxygen radical damage to lipid and carbohydrate." Food Additives and Contaminants 3, no. 4 (October 1986): 289–93. http://dx.doi.org/10.1080/02652038609373595.

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40

Lancaster, Frank E., and James F. Lawrence. "High-performance liquid chromatographic separation of carminic acid, α- and β-bixin, and α- and β-norbixin, and the determination of carminic acid in foods." Journal of Chromatography A 732, no. 2 (May 1996): 394–98. http://dx.doi.org/10.1016/0021-9673(95)01332-6.

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Cavalcanti, Graycyellê R. S., Francisco Rodrigues, Guanzheng Zhuang, Sebastien Balme, Jean-Marc Janot, Maria G. Fonseca, and Maguy Jaber. "Inorganic-organic hybrid pigments based on carminic acid and clay minerals." Dyes and Pigments 190 (June 2021): 109306. http://dx.doi.org/10.1016/j.dyepig.2021.109306.

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42

SUGIMOTO, Naoki, Atsuko TADA, Takako SUEMATSU, Kazunori ARIFUKU, Takeshi SAITO, Toshihide IHARA, Yuuichi YOSHIDA, et al. "Absolute Quantification of Carminic Acid in Cochineal Extract by Quantitative NMR." Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 51, no. 1 (2010): 19–27. http://dx.doi.org/10.3358/shokueishi.51.19.

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43

Gawȩda, Sylwia, Graẑyna Stochel, and Konrad Szaciłowski. "Photosensitization and Photocurrent Switching in Carminic Acid/Titanium Dioxide Hybrid Material." Journal of Physical Chemistry C 112, no. 48 (November 11, 2008): 19131–41. http://dx.doi.org/10.1021/jp804700d.

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44

Floquet, Cedric F. A., Vincent J. Sieben, Bruce A. MacKay, and Farshid Mostowfi. "Determination of boron in produced water using the carminic acid assay." Talanta 150 (April 2016): 240–52. http://dx.doi.org/10.1016/j.talanta.2015.12.010.

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45

Guillermin, David, Theau Debroise, Pollyana Trigueiro, Laurence de Viguerie, Baptiste Rigaud, Fabrice Morlet-Savary, Sébastien Balme, et al. "New pigments based on carminic acid and smectites: A molecular investigation." Dyes and Pigments 160 (January 2019): 971–82. http://dx.doi.org/10.1016/j.dyepig.2018.07.021.

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46

Filik, Hayati, Esma Tütem, Reşat Apak, and Erol Erçağ. "Spectrophotometric determination of gallium(III) with carminic acid and hexadecylpyridinium chloride." Mikrochimica Acta 129, no. 1-2 (March 1998): 57–63. http://dx.doi.org/10.1007/bf01246849.

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47

ALLEVI, P., M. ANASTASIA, S. BINGHAM, P. CIUFFREDA, A. FIECCHI, G. CIGHETTI, M. MUIR, A. SCALA, and J. TYMAN. "ChemInform Abstract: Synthesis of Carminic Acid, the Colorant Principle of Cochineal." ChemInform 29, no. 22 (June 22, 2010): no. http://dx.doi.org/10.1002/chin.199822124.

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48

AL-Temimei, F. A., S. H. Mohsen, H. H. Abbas, and A. A. Abojassim. "Theoretical Design of New Healthy Organic Dyes for Solar Cell Applications with Favorite Medicinal Effect." CARDIOMETRY, no. 25 (February 14, 2023): 1456–62. http://dx.doi.org/10.18137/cardiometry.2022.25.14561462.

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In this work, a computational investigation was used to design and study new materials based on carminic acid isomers as organic dyes for DSSCs. Density functional theory (DFT) was applied to report the ground state and the excited state characteristic was reported by utilizing time-dependent DFT (TDDFT) methods. Some electronic, optical, photolytic and electron transfer properties are evaluated to achieve our study. The results indicate that modifying the chemical structure of a dye by doping improves light harvesting efficiency while reducing the driving force for electron injection and the potential of dye renewal while boosting dye aggregation on the electrode surface. The new structures dyes displays strong charge transfer absorption bands in the visible, excellent electronic, sufficient driving force and photoelectric conversion efficiency in comparison with carminic acid. Also, All suggested dyes have sufficient properties to achieve high PCE of the DSSCs. These results are adequate for a potential effective electron injection process. Accordingly, the theoretical methods are significant to provide experimental methods for designing new, highly efficient materials for optoelectronic applications. It was found that these dyes do not have any medical effect on human health.
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Cañamares, M. V., J. V. Garcia-Ramos, C. Domingo, and S. Sanchez-Cortes. "Surface-enhanced Raman scattering study of the anthraquinone red pigment carminic acid." Vibrational Spectroscopy 40, no. 2 (March 2006): 161–67. http://dx.doi.org/10.1016/j.vibspec.2005.08.002.

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50

Panadero, S., A. Gómez-Hens, and D. Pérez-Bendito. "Kinetic determination of carminic acid by its inhibition of lanthanide-sensitized luminescence." Fresenius' Journal of Analytical Chemistry 357, no. 1 (January 8, 1997): 80–83. http://dx.doi.org/10.1007/s002160050115.

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