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Relevant bibliographies by topics / Cartilage cells

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Academic literature on the topic 'Cartilage cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 March 2023

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Journal articles on the topic "Cartilage cells"

1

Åberg, Thomas, Ritva Rice, David Rice, Irma Thesleff, and Janna Waltimo-Sirén. "Chondrogenic Potential of Mouse Calvarial Mesenchyme." Journal of Histochemistry & Cytochemistry 53, no. 5 (May 2005): 653–63. http://dx.doi.org/10.1369/jhc.4a6518.2005.

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Facial and calvarial bones form intramembranously without a cartilagenous model; however, cultured chick calvarial mesenchyme cells may differentiate into both osteoblasts and chondroblasts and, in rodents, small cartilages occasionally form at the sutures in vivo. Therefore, we wanted to investigate what factors regulate normal differentiation of calvarial mesenchymal cells directly into osteoblasts. In embryonic mouse heads and in cultured tissue explants, we analyzed the expression of selected transcription factors and extracellular matrix molecules associated with bone and cartilage develo

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Holmbeck, Kenn, Paolo Bianco, Kali Chrysovergis, Susan Yamada, and Henning Birkedal-Hansen. "MT1-MMP–dependent, apoptotic remodeling of unmineralized cartilage." Journal of Cell Biology 163, no. 3 (November 10, 2003): 661–71. http://dx.doi.org/10.1083/jcb.200307061.

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Skeletal tissues develop either by intramembranous ossification, where bone is formed within a soft connective tissue, or by endochondral ossification. The latter proceeds via cartilage anlagen, which through hypertrophy, mineralization, and partial resorption ultimately provides scaffolding for bone formation. Here, we describe a novel and essential mechanism governing remodeling of unmineralized cartilage anlagen into membranous bone, as well as tendons and ligaments. Membrane-type 1 matrix metalloproteinase (MT1-MMP)–dependent dissolution of unmineralized cartilages, coupled with apoptosis

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Yi, Hee-Gyeong, Yeong-Jin Choi, Jin Woo Jung, Jinah Jang, Tae-Ha Song, Suhun Chae, Minjun Ahn, Tae Hyun Choi, Jong-Won Rhie, and Dong-Woo Cho. "Three-dimensional printing of a patient-specific engineered nasal cartilage for augmentative rhinoplasty." Journal of Tissue Engineering 10 (January 2019): 204173141882479. http://dx.doi.org/10.1177/2041731418824797.

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Autologous cartilages or synthetic nasal implants have been utilized in augmentative rhinoplasty to reconstruct the nasal shape for therapeutic and cosmetic purposes. Autologous cartilage is considered to be an ideal graft, but has drawbacks, such as limited cartilage source, requirements of additional surgery for obtaining autologous cartilage, and donor site morbidity. In contrast, synthetic nasal implants are abundantly available but have low biocompatibility than the autologous cartilages. Moreover, the currently used nasal cartilage grafts involve additional reshaping processes, by meticu

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Mazor, Marija, Annabelle Cesaro, Mazen Ali, Thomas M. Best, Eric Lespessailles, and Hechmi Toumi. "Progenitor Cells From Cartilage." Medicine & Science in Sports & Exercise 49, no. 5S (May 2017): 681. http://dx.doi.org/10.1249/01.mss.0000518798.14205.0d.

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Benjamin, M., C. W. Archer, and J. R. Ralphs. "Cytoskeleton of cartilage cells." Microscopy Research and Technique 28, no. 5 (August 1, 1994): 372–77. http://dx.doi.org/10.1002/jemt.1070280503.

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Suchorska, Wiktoria Maria, Ewelina Augustyniak, Magdalena Richter, Magdalena Łukjanow, Violetta Filas, Jacek Kaczmarczyk, and Tomasz Trzeciak. "Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells." Postępy Higieny i Medycyny Doświadczalnej 71, no. 1 (June 19, 2017): 0. http://dx.doi.org/10.5604/01.3001.0010.3831.

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Human articular cartilage has a poor regenerative capacity. This often results in the serious joint disease- osteoarthritis (OA) that is characterized by cartilage degradation. An inability to self-repair provided extensive studies on AC regeneration. The cell-based cartilage tissue engineering is a promising approach for cartilage regeneration. So far, numerous cell types have been reported to show chondrogenic potential, among others human embryonic stem cells (hESCs).

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Le, Hanxiang, Weiguo Xu, Xiuli Zhuang, Fei Chang, Yinan Wang, and Jianxun Ding. "Mesenchymal stem cells for cartilage regeneration." Journal of Tissue Engineering 11 (January 2020): 204173142094383. http://dx.doi.org/10.1177/2041731420943839.

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Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune diseases. Owing to the avascular structure and low metabolic activities of chondrocytes, cartilage generally does not self-repair following an injury. Currently, clinical interventions for cartilage injuries include chondrocyte implantation, microfracture, and osteochondral transplantation. However, rather than restoring cartilage integrity, these methods only postpone further cartilage deterioration. Stem cell therapies, especially mesenchymal stem cell (MSCs) therapies, were found to be a feasible strategy in

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Zhang, Hong, Xiaopeng Zhao, Zhiguang Zhang, Weiwei Chen, and Xinli Zhang. "An Immunohistochemistry Study of Sox9, Runx2, and Osterix Expression in the Mandibular Cartilages of Newborn Mouse." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/265380.

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The purpose of this study is to investigate the spacial expression pattern and functional significance of three key transcription factors related to bone and cartilage formation, namely, Sox9, Runx2, and Osterix in cartilages during the late development of mouse mandible. Immunohistochemical examinations of Sox9, Runx2, and Osterix were conducted in the mandibular cartilages of the 15 neonatal C57BL/6N mice. In secondary cartilages, both Sox9 and Runx2 were weakly expressed in the polymorphic cell zone, strongly expressed in the flattened cell zone and throughout the entire hypertrophic cell z

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Hayes, Anthony J., John Whitelock, and James Melrose. "Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis." International Journal of Molecular Sciences 23, no. 4 (February 9, 2022): 1934. http://dx.doi.org/10.3390/ijms23041934.

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The aim of this study was to highlight the roles of perlecan in the regulation of the development of the rudiment developmental cartilages and growth plate cartilages, and also to show how perlecan maintains permanent articular cartilage homeostasis. Cartilage rudiments are transient developmental templates containing chondroprogenitor cells that undergo proliferation, matrix deposition, and hypertrophic differentiation. Growth plate cartilage also undergoes similar changes leading to endochondral bone formation, whereas permanent cartilage is maintained as an articular structure and does not

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Schilling, T. F., C. Walker, and C. B. Kimmel. "The chinless mutation and neural crest cell interactions in zebrafish jaw development." Development 122, no. 5 (May 1, 1996): 1417–26. http://dx.doi.org/10.1242/dev.122.5.1417.

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During vertebrate development, neural crest cells are thought to pattern many aspects of head organization, including the segmented skeleton and musculature of the jaw and gills. Here we describe mutations at the gene chinless, chn, that disrupt the skeletal fates of neural crest cells in the head of the zebrafish and their interactions with muscle precursors. chn mutants lack neural-crest-derived cartilage and mesoderm-derived muscles in all seven pharyngeal arches. Fate mapping and gene expression studies demonstrate the presence of both undifferentiated cartilage and muscle precursors in mu

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Dissertations / Theses on the topic "Cartilage cells"

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Cook, James L. "Three-dimensional chondrocyte culture : in vitro and in vivo applications /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9924877.

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Srinivasan, Jayendran. "Investigation of internal fluid pressure in cells." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4177.

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Thesis (M.S.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains x, 114 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 69-77).

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Mouw, Janna Kay. "Mechanoregulation of chondrocytes and chondroprogenitors the role of TGF-BETA and SMAD signaling /." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11232005-103041/.

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Thesis (Ph. D.)--Bioengineering, Georgia Institute of Technology, 2006.<br>Harish Radhakrishna, Committee Member ; Christopher Jacobs, Committee Member ; Andres Garcia, Committee Member ; Marc E. Levenston, Committee Chair ; Barbara Boyan, Committee Member.

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Yang, Ziquan. "Repair of cartilage injury using gene modified stem cells and acellular cartilage matrix." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501585.

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Bishop, Joanna Charlotte. "Biology of the articular cartilage progenitor cells." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55374/.

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Brodkin, Kathryn Rhea. "Chondrocyte behavior in monolayer culture : the effects of protein substrates and culture media." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/20216.

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Tsang, Kwok-yeung. "Molecular pathogenesis of abnormal chondrocyte differentiation in a transgenic mouse model /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B35132796.

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Togo, Takeshi. "Identification of cartilage progenitor cells in the adult ear perichondrium : utilization for cartilage reconstruction." Kyoto University, 2008. http://hdl.handle.net/2433/135826.

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Kraft, Jeffrey J. "Developing a cartilage tissue equivalent using chondrocytes and mesenchymal stem cells." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 90 p, 2007. http://proquest.umi.com/pqdweb?did=1397900431&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Clements, Kristen Mary. "Mechanical disruption of articular cartilage cells and matrix." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340082.

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Books on the topic "Cartilage cells"

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1933-, Malinin Theodore I., ed. Microscopic and histochemical manifestations of hyaline cartilage dynamics. Jena: Urban & Fischer Verlag, 1999.

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Malinin, George I. Microscopic and histochemical manifestations of hyaline cartilage dynamics. Jena, Germany: Urban & Fischer, 1999.

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F, Stoltz J., and International Symposium on Mechanobiology of Cartilage and Chondrocyte (1st : 1999 : Sainte-Maxime, France), eds. Mechanobiology: Cartilage and chondrocyte. Amsterdam: IOS Press, 2000.

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Khan, Wasim S. Stem cells and cartilage tissue engineering approaches to orthopaedic surgery. Hauppauge, N.Y: Nova Science Publishers, 2009.

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International, Workshop on Cells and Cytokines in Bone and Cartilage (3rd 1990 Davos Switzerland). Third International Workshop on Cells and Cytokines in Bone and Cartilage: 8-11 April 1990, Davos, Switzerland : abstracts. New York, N.Y: Springer International, 1990.

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International Workshop on Cells and Cytokines in Bone and Cartilage (2nd 1988 Davos, Switzerland). Second International Workshop on Cells and Cytokines in Bone and Cartilage: 9-12 April 1988, Davos, Switzerland : abstracts. New York, N.Y: Springer International, 1988.

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International Workshop on Cells and Cytokines in Bone and Cartilage (4th 1992 Davos, Switzerland). Fourth Workshop on Cells and Cytokines in Bone and Cartilage: January 11-14, 1992, Davos, Switzerland : abstracts. New York, N.Y: Springer International, 1992.

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8

F, Stoltz J., ed. Mechanobiology: Cartilage and chondrocyte. Amsterdam: IOS Press, 2006.

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Mechanobiology: Cartilage and chondrocyte. Amsterdam: IOS Press, 2008.

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10

Sampat, Sonal Ravin. Optimization of Culture Conditions for Cartilage Tissue Engineering Using Synovium-Derived Stem Cells. [New York, N.Y.?]: [publisher not identified], 2014.

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Book chapters on the topic "Cartilage cells"

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Frayssinet, P., J. L. Jouve, and E. Viehweger. "Cartilage Cells." In Biomechanics and Biomaterials in Orthopedics, 219–28. London: Springer London, 2004. http://dx.doi.org/10.1007/978-1-4471-3774-0_23.

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Oellerich, Diana, and Nicolai Miosge. "Chondrogenic Progenitor Cells and Cartilage Repair." In Cartilage, 59–72. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53316-2_3.

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Diederichs, Solvig, and Wiltrud Richter. "Induced Pluripotent Stem Cells and Cartilage Regeneration." In Cartilage, 73–93. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53316-2_4.

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Anz, Adam W., and Caleb O. Pinegar. "The Role of Stem Cells in Surgical Repair." In Cartilage Restoration, 151–64. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77152-6_13.

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Pattappa, Girish, Brandon D. Markway, Denitsa Docheva, and Brian Johnstone. "Physioxic Culture of Chondrogenic Cells." In Cartilage Tissue Engineering, 45–63. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2839-3_5.

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van Osch, Gerjo J. V. M., Andrea Barbero, Mats Brittberg, Diego Correa, Solvig Diederichs, Mary B. Goldring, Tim Hardingham, et al. "Cells for Cartilage Regeneration." In Cell Engineering and Regeneration, 33–99. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-08831-0_1.

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van Osch, Gerjo J. V. M., Andrea Barbero, Mats Brittberg, Diego Correa, Solvig Diederichs, Mary B. Goldring, Tim Hardingham, et al. "Cells for Cartilage Regeneration." In Cell Engineering and Regeneration, 1–67. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-37076-7_1-1.

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Gardner, Oliver F. W., Mauro Alini, and Martin J. Stoddart. "Mesenchymal Stem Cells Derived from Human Bone Marrow." In Cartilage Tissue Engineering, 41–52. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2938-2_3.

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Mahmoudifar, Nastaran, and Pauline M. Doran. "Mesenchymal Stem Cells Derived from Human Adipose Tissue." In Cartilage Tissue Engineering, 53–64. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2938-2_4.

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Dicks, Amanda R., Nancy Steward, Farshid Guilak, and Chia-Lung Wu. "Chondrogenic Differentiation of Human-Induced Pluripotent Stem Cells." In Cartilage Tissue Engineering, 87–114. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2839-3_8.

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Conference papers on the topic "Cartilage cells"

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Gunja, Najmuddin, Jason Fong, Andrea Tan, Man-Yu Moy, Duo Xu, Grace O’Connell, J. Chloe Bulinski, Gerard A. Ateshian, and Clark T. Hung. "Priming of Synovium-Derived Mesenchymal Stem Cells for Cartilage Tissue Engineering." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19453.

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The clinical potential of stem cells has driven forward efforts toward their optimization for tissue engineering applications. The intimal layer of the synovium is composed of two cell types, macrophages and fibroblast-like cells. The fibroblast-like cells, often referred to as synovial-derived mesenchymal stem cells (sMSCs), have the capability to differentiate down a chondrogenic lineage1. In addition, in vivo tests have shown that synovial cells may be recruited from the synovial membrane to aid in the repair of articular cartilage defects2.

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Wartella, K. A., and J. S. Wayne. "Effect of Mechanical Stimulation on Mesenchymal Stem Cell Seeded Cartilage Constructs." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19645.

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Articular cartilage is a specialized tissue with a restricted capacity for self-repair. Thus, there is a need for a functional tissue replacement product for cartilage due to the ever-increasing occurrence of cartilage injuries and osteoarthritis. Engineering a cartilage replacement construct entails a combination of source cells, cytokines/growth factors, differentiation factors, and a supportive structure to mimic the native environment [1]. An abundant source of cells, isolated from adult bone marrow, are mesenchymal stem cells (MSCs), which when isolated can be a rich cell source given the

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Erickson, Geoffrey R., Jeffrey M. Gimble, Dawn Franklin, and Farshid Guilak. "Adipose Tissue-Derived Stromal Cells Grown in Three-Dimensional Aliginate Constructs Display a Chondrogenic Phenotype." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2503.

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Abstract Articular cartilage is the connective tissue that lines the surfaces of diarthrodial joints in the human body. Because cartilage is avascular, aneural, and alymphatic, it has a limited capacity for repair. Techniques such as microfracture, transplantation of autologous cartilage, and allograft or xenograft transplantations have not proven fully effective in treating cartilage damage. Current therapy is focusing on cell-based treatments such as autologous chondrocyte transplantation [1,2]. However, this method faces several limitations, as the donor site can provide a limited number of

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Babalola, Omotunde M., and Lawrence J. Bonassar. "Parametric Finite Element Analysis of Physical Stimuli Resulting From Mechanical Stimulation of Tissue Engineered Cartilage." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192633.

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The avascular nature of cartilage results in its limited inability to repair itself upon injury. As a result numerous approaches are being investigated as potential therapies for repair, including tissue engineering strategies. In addition, due to the low density of chondrocytes and the characteristic de-differentiation of the cells when expanded in monolayer [1], other cell types are being investigated as a source for cartilage repair as well. Mesenchymal stem cells (MSCs), which have been shown to differentiate into cells of several lineages including chondrocytes, osteoblasts and adipocytes

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Alegre-Aguarón, Elena, Sonal R. Sampat, Perry J. Hampilos, J. Chloë Bulinski, James L. Cook, Lewis M. Brown, and Clark T. Hung. "Biomarker Identification Under Growth Factor Priming for Cartilage Tissue Engineering." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80374.

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Adult articular cartilage has a poor healing capacity, which has lead to intense research toward development of cell-based therapies for cartilage repair. The destruction of articular cartilage results in osteoarthritis (OA), which affects about 27 million Americans. In order to create functional tissue, it is essential to mimic the native environment by optimizing expansion protocols. Cell passaging and priming with chemical or physical factors are often necessary steps in cell-based strategies for regenerative medicine [1]. The ability to identify biomarkers that can act as predictors of cel

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Nansai, Ryosuke, Mamoru Ogata, Junichi Takeda, Wataru Ando, Norimasa Nakamura, and Hiromichi Fujie. "Surface and Bulk Stiffness of the Mature Porcine Cartilage-Like Tissue Repaired With a Scaffold-Free, Stem Cell-Based Tissue Engineered Construct (TEC)." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204404.

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Since the healing capacity of articular cartilage is limited, it is important to develop cell-based therapies for the repair of cartilage. Although synthetic or animal-derived scaffolds are frequently used for effective cell delivery long-term safety and efficiency of such scaffolds still remain unclear. We have been developing a new tissue engineering technique for cartilage repair using a scaffold-free tissue engineered construct (TEC) bio-synthesized from synovium-derived mesenchymal stem cells (MSCs) [1]. As the TEC specimen is composed of cells with their native extracellular matrix, we b

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Susa, Tomoya, Ryosuke Nansai, Norimasa Nakamura, and Hiromichi Fujie. "Influence of Permeability on the Compressive Property of Articular Cartilage: A Scaffold-Free, Stem Cell-Based Therapy for Cartilage Repair." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53365.

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Since the healing capacity of articular cartilage is limited, it is important to develop cell-based therapies for the repair of cartilage. Although synthetic or animal-derived scaffolds are frequently used for effective cell delivery long-term safety and efficiency of such scaffolds still remain unclear. We have been studying on a scaffold-free tissue engineered construct (TEC) bio-synthesized from synovium-derived mesenchymal stem cells (MSCs) [1]. As the TEC specimen is composed of cells with their native extracellular matrix, we believe that it is free from concern regarding long term immun

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Kim, Minwook, Isaac E. Erickson, Jason A. Burdick, George R. Dodge, and Robert L. Mauck. "Differential Chondrogenic Potential of Human and Bovine Mesenchymal Stem Cells in Agarose and Photocrosslinked Hyaluronic Acid Hydrogels." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19461.

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Articular cartilage has a limited regenerative capacity, and there exist no methodologies to restore structure and function after damage or degeneration. This has focused intense work on cell-based therapies for cartilage repair, with considerable literature demonstrating that chondrocytes in vitro and in vivo can generate cartilage-like tissue replacements. However, use of primary cells is limited by the amount and quality of autologous donor cells and tissue. Multipotential mesenchymal stem cells (MSCs) derived from bone marrow offer an alternative cell source for cartilage tissue engineerin

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Haudenschild, Anne K., Xiangnan Zhou, Cai Li, Jerry C. Hu, J. Kent Leach, Kyriacos A. Athanasiou, and Laura Marcu. "Multimodal evaluation of tissue engineered cartilage maturation in a pre-clinical implantation model (Conference Presentation)." In Optical Interactions with Tissue and Cells XXX, edited by Hope T. Beier and Bennett L. Ibey. SPIE, 2019. http://dx.doi.org/10.1117/12.2509047.

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van Turnhout, Mark C., Stefan A. H. de Vries, Corrinus C. van Donkelaar, and Cees W. J. Oomens. "Mechanical Chondrocyte Damage Thresholds." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80426.

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Chondrocyte content in articular cartilage is very low. Only 2% to 5% of the tissue volume consists of chondrocytes [1]. Yet, these cells are responsible for maintenance of the tissue. Hence, the loss of chondrocytes that is often occurring at an early stage of cartilage degeneration is detrimental to articular cartilage. Excessive mechanical loading is known to be a cause of cell death. However, mechanical thresholds beyond which chondrocyte apoptosis would be induced are unknown.

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Reports on the topic "Cartilage cells"

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de Sousa, Eduardo, Renata Matsui, Leonardo Boldrini, Leandra Baptista, and José Mauro Granjeiro. Mesenchymal stem cells for the treatment of articular cartilage defects of the knee: an overview of systematic reviews. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0114.

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Review question / Objective: Population: adults (aged between 18 and 50 years) with traumatic knee lesions who underwent treatment with mesenchymal stem cells; Intervention: defined by the treatment with mesenchymal stem cells; The comparison group: treatment with autologous chondrocytes or microfracture treatments; Primary outcome: formation of cartilage neo tissue in the defect area, determined by magnetic resonance imaging (MRI) or by direct visualization in second-look knee arthroscopy.; Secondary outcomes: based on clinical scores such as visual analog scale (VAS) for pain, Western Ontari

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Leach, Roland M., Mark Pines, Carol V. Gay, and Shmuel Hurwitz. In vivo and in vitro Chondrocyte Metabolism in Relationship to the Developemnt of Tibial Dyschondroplasia in Broiler Chickens. United States Department of Agriculture, July 1993. http://dx.doi.org/10.32747/1993.7568090.bard.

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Skeletal deformities are a significant financial and welfare problem for the world poultry industry. Tibial dyschondroplasia (TD) is the most prevalent skeletal abnormality found in young broilers, turkeys and ducks. Tibial dyschondroplasia results from a perturbation of the sequence of events in the epiphyseal growth plate, the tissue responsible for longitudinal bone growth. The purpose of this investigation was to test the hypothesis that TD was the result of a failure of growth plate chondrocytes to differentiate and express the chemotactic molecules required for cartilage vascularization.

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Huard, Johnny. Articular Cartilage Repair Through Muscle Cell-Based Tissue Engineering. Fort Belvoir, VA: Defense Technical Information Center, March 2011. http://dx.doi.org/10.21236/ada552048.

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Martin, James A. Promoting Cartilage Stem Cell Activity to Improve Recovery from Joint Fracture. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada571622.

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Martin, James A. Promoting Cartilage Stem Cell Activity to Improve Recovery from Joint Fracture. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada580998.

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Funkenstein, Bruria, and Cunming Duan. GH-IGF Axis in Sparus aurata: Possible Applications to Genetic Selection. United States Department of Agriculture, November 2000. http://dx.doi.org/10.32747/2000.7580665.bard.

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Many factors affect growth rate in fish: environmental, nutritional, genetics and endogenous (physiological) factors. Endogenous control of growth is very complex and many hormone systems are involved. Nevertheless, it is well accepted that growth hormone (GH) plays a major role in stimulating somatic growth. Although it is now clear that most, if not all, components of the GH-IGF axis exist in fish, we are still far from understanding how fish grow. In our project we used as the experimental system a marine fish, the gilthead sea bream (Sparus aurata), which inhabits lagoons along the Mediter

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