Relevant bibliographies by topics / Cartilage extracellular matrix (ECM)

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cartilage extracellular matrix (ECM)'

Author: Grafiati
Published: 11 December 2022
Last updated: 31 July 2025

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Journal articles on the topic "Cartilage extracellular matrix (ECM)"

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Vertel, B. M. "The Formation of Cartilage Extracellular Matrix." Proceedings, annual meeting, Electron Microscopy Society of America 46 (1988): 230–31. http://dx.doi.org/10.1017/s0424820100103218.

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Normal cartilage function is dependent upon the unique structural properties of the extensive extracellular matrix (ECM). In final assembled form, the ECM of hyaline cartilage is composed of abundant amounts of proteoglycan (PG) and type II collagen. Additional collagens and glycoproteins may be important structural components as well. Through their concentration of negative charges, PGs confer upon the cartilage ECM the ability to retain high levels of hydration and thereby resist compression. Type II collagen fibers contribute to the tensile strength of cartilage.In the cartilage ECM, PG mon
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Roncada, T., and D. J. Kelly. "DEVELOPMENT OF PHOTO-CROSSLINKABLE DECELLULARIZED EXTRACELLULAR MATRIX HYDROGELS FOR CARTILAGE TISSUE ENGINEERING." Orthopaedic Proceedings 106-B, SUPP_2 (2024): 79. http://dx.doi.org/10.1302/1358-992x.2024.2.079.

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Cartilage lacks the ability to self-repair when damaged, which can lead to the development of degenerative joint disease. Despite intensive research in the field of cartilage tissue engineering, there is still no regenerative treatment that consistently promotes the development of hyaline cartilage. Extracellular matrix (ECM) derived hydrogels have shown to support cell adhesion, growth and differentiation [1,2]. In this study, porcine articular cartilage was decellularized, solubilised and subsequently modified into a photo-crosslinkable methacrylated cartilage ECM hydrogel. Bone marrow deriv
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Ocken, Alexander R., Madeline M. Ku, Tamara L. Kinzer-Ursem, and Sarah Calve. "Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development." Molecular & Cellular Proteomics 19, no. 7 (2020): 1220–35. http://dx.doi.org/10.1074/mcp.ra120.001998.

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Perlecan is a critical proteoglycan found in the extracellular matrix (ECM) of cartilage. In healthy cartilage, perlecan regulates cartilage biomechanics and we previously demonstrated perlecan deficiency leads to reduced cellular and ECM stiffness in vivo. This change in mechanics may lead to the early onset osteoarthritis seen in disorders resulting from perlecan knockdown such as Schwartz-Jampel syndrome (SJS). To identify how perlecan knockdown affects the material properties of developing cartilage, we used imaging and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to study the
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Huber, Jessica E., Alan Spievack, Robert L. Ringel, Abby Simmons-Byrd, and Stephen Badylak. "Extracellular Matrix as a Scaffold for Laryngeal Reconstruction." Annals of Otology, Rhinology & Laryngology 112, no. 5 (2003): 428–33. http://dx.doi.org/10.1177/000348940311200508.

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Porcine-derived xenogeneic extracellular matrix (ECM) has been successfully used as a scaffold for tissue repair and reconstruction in numerous preclinical animal studies and human applications. These scaffolds are completely and rapidly degraded and replaced by host-derived tissues that frequently mimic the original tissue composition and architecture. The purpose of the present study was to examine the morphology of ECM scaffolds after their use for laryngeal reconstruction. Thirty adult female dogs were subjected to a partial hemilaryngectomy. The right thyroid cartilage and vocal fold were
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Georgieva, Veronika S., Julia Etich, Björn Bluhm, et al. "Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage." International Journal of Molecular Sciences 21, no. 11 (2020): 4112. http://dx.doi.org/10.3390/ijms21114112.

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MicroRNAs (miRNAs) regulate cartilage differentiation and contribute to the onset and progression of joint degeneration. These small RNA molecules may affect extracellular matrix organization (ECM) in cartilage, but for only a few miRNAs has this role been defined in vivo. Previously, we showed that cartilage-specific genetic ablation of the Mirc24 cluster in mice leads to impaired cartilage development due to increased RAF/MEK/ERK pathway activation. Here, we studied the expression of the cluster in cartilage by LacZ reporter gene assays and determined its role for extracellular matrix homeos
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Gao, Yue, Shuyun Liu, Jingxiang Huang, et al. "The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/648459.

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Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. Cell signaling through integrins regulates several chondrocyte functions, including differentiation, metabolism, matrix remodeling, responses to mechanical stimulation, and cell survival
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Peng, Gordon, Sean M. McNary, Kyriacos A. Athanasiou, and A. Hari Reddi. "Superficial Zone Extracellular Matrix Extracts Enhance Boundary Lubrication of Self-Assembled Articular Cartilage." CARTILAGE 7, no. 3 (2015): 256–64. http://dx.doi.org/10.1177/1947603515612190.

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Objective Previous work has shown that increasing the production of boundary lubricant, superficial zone protein (SZP), did not reduce the friction coefficient of self-assembled articular cartilage constructs and was possibly due to poor retention of the lubricant. The aim of this investigation was to reduce the friction coefficient of self-assembled articular cartilage constructs through enhancing SZP retention by the exogenous addition of extracellular matrix (ECM) extracted from the superficial zone of native articular cartilage. Design Superficial zone cartilage was shaved from juvenile bo
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Mariadoss, Arokia Vijaya Anand, and Chau-Zen Wang. "Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions." International Journal of Molecular Sciences 24, no. 19 (2023): 14895. http://dx.doi.org/10.3390/ijms241914895.

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The tyrosine kinase family receptor of discoidin domain receptors (DDR1 and DDR2) is known to be activated by extracellular matrix collagen catalytic binding protein receptors. They play a remarkable role in cell proliferation, differentiation, migration, and cell survival. DDR1 of the DDR family regulates matrix-metalloproteinase, which causes extracellular matrix (ECM) remodeling and reconstruction during unbalanced homeostasis. Collagenous-rich DDR1 triggers the ECM of cartilage to regenerate the cartilage tissue in osteoarthritis (OA) and temporomandibular disorder (TMD). Moreover, DDR2 is
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Gilbert, Sophie Jane, Cleo Selina Bonnet, and Emma Jane Blain. "Mechanical Cues: Bidirectional Reciprocity in the Extracellular Matrix Drives Mechano-Signalling in Articular Cartilage." International Journal of Molecular Sciences 22, no. 24 (2021): 13595. http://dx.doi.org/10.3390/ijms222413595.

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The composition and organisation of the extracellular matrix (ECM), particularly the pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the presence of proteoglycans such as aggrecan, entrapped within a type II collagen fibrillar network, confers mechanical resilience underweight-bearing. Furthermore, components of the PCM including type VI collagen, perlecan, small leucine-rich proteoglycans—decorin and biglycan—and fibronectin facilitate the transduction of both biomechanical and biochemical signals to the residing chondrocytes, thereby regulati
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Sands, Ian, Jinhyung Lee, Wuxia Zhang, and Yupeng Chen. "RNA Delivery via DNA-Inspired Janus Base Nanotubes for Extracellular Matrix Penetration." MRS Advances 5, no. 16 (2020): 815–23. http://dx.doi.org/10.1557/adv.2020.47.

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AbstractRNA delivery into deep tissues with dense extracellular matrix (ECM) has been challenging. For example, cartilage is a major barrier for RNA and drug delivery due to its avascular structure, low cell density and strong negative surface charge. Cartilage ECM is comprised of collagens, proteoglycans, and various other noncollagneous proteins with a spacing of 20nm. Conventional nanoparticles are usually spherical with a diameter larger than 50-60nm (after cargo loading). Therefore, they presented limited success for RNA delivery into cartilage. Here, we developed Janus base nanotubes (JB
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Dissertations / Theses on the topic "Cartilage extracellular matrix (ECM)"

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Kuaha, Kunnika. "Environments for zonal cartilage tissue engineering." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/81992/1/Kunnika_Kuaha_Thesis.pdf.

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Articular cartilage is a highly organized tissue with cellular and matrix properties that vary with depth zones. Regenerating this zonal organization has proven difficult in tissue-engineered cartilage to treat damaged cartilage. In this thesis, we evaluated the effects of culture environments that mimic aspects of the native cartilage environment on chondrocyte subpopulations. We found that decellularized cartilage matrix can improve zonal tissue-engineered cartilage. Also, chondrocytes respond to signals from bone cells and compressive stimulation in a zone-dependent manner. These results hi
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Han, Lin Ph D. Massachusetts Institute of Technology. "Nanomechanics of cartilage extracellular matrix macromolecules." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42134.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.<br>Includes bibliographical references (p. 187-201).<br>In this thesis, the shear and self-adhesion nanomechanical properties between opposing cartilage aggrecan macromolecules were probed. In addition, nanoscale dynamic oscillatory mechanical properties of cartilage and its type II collagen network was measured. Aggrecan shear nanomechanics was assessed via microcontact printing and lateral force microscopy. Lateral force between aggrecan and the probe tip, and compression of aggrecan was
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Kammerer, Theresa Anne [Verfasser], and Sebastian Johannes [Akademischer Betreuer] Arnold. "Visualization of the Extracellular Matrix (ECM) by fluorescent tagging of ECM components in mouse." Freiburg : Universität, 2021. http://d-nb.info/1232644803/34.

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Randles, Michael. "Proteomic analyses of kidney glomerular extracellular matrix in health and disease." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/proteomic-analyses-of-kidney-glomerular-extracellular-matrix-in-health-and-disease(a39fe408-db06-4d80-b97b-4e0651bf7bc3).html.

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Glomerular filtration is a vital physiological process removing waste products from the circulation and this process occurs across the glomerular filtration barrier (GFB). The cells and extracellular matrix (ECM), which form this barrier, are exposed to forces during ultrafiltration and special adaptation is required to withstand these forces. Dysfunction in cellular adhesion machinery or ECM assembly within the GFB causes loss of selective glomerular filtration, however, the mechanisms governing these processes are poorly understood. To this end we sought to characterise the glomerular ECM an
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Marengo, Kaitlyn A. "The Incorporation of Decellularized Cardiac ECM into Fibrin Microthreads." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/843.

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Stem cell therapies have shown promising capabilities in regaining the functionality of scar tissue following a myocardial infarction. Biological sutures composed of fibrin have been shown to more effectively deliver human mesenchymal stem cells (hMSCs) to the heart when compared to traditional cell delivery mechanisms. While the biological sutures do show promise, improvements can be made. To enhance the fibrin sutures, we propose to incorporate native cardiac extracellular matrix (ECM) into the fibrin microthreads to produce a more in vivo-like environment. This project investigated the effe
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Villaggio, Giusy. "Relationship between extracellular matrix (ECM) components and mineralization in bone marrow stromal cells." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1492.

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The relations between cells and extracellular matrix seem to orchestrate tissue organization by regulating cell functions during fetal development and throughout normal adult life. Thus, focusing on the innate ability of the native ECM to better modulate cell behavior, the coating of synthetic biomaterials with cell-derived decellularized extracellular matrices is a promising approach to confer bioactivity to inert materials and direct the fate of host or transplanted cells in tissue engineering applications. This study aims to better understand ECM influence on human bone marrow stem cells an
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Kwak, Hyo Bum. "Exercise training regulation of extracellular matrix and remodeling in the aging rat heart." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2761.

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Hancock, Sian. "Ultrastructural organisation and molecular interactions in the hypertrophic cartilage extracellular matrix." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55149/.

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Type X collagen is a member of the family of network-forming collagens, it contains a triple helical domain flanked by two non-collagenous (NC) domains, NC2 at the N-terminal and NCI at the C-terminal. It is expressed and synthesised by hypertrophic chondrocytes of the epiphyseal growth plates during the process of endochondral ossification (EO). This process involves replacement of a cartilaginous anlagen by bone, the coordination of chondrocyte proliferation, maturation and hypertrophy are followed by calcification of hypertrophic cartilage, vascular invasion and deposition of a bone matrix.
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McKenna, Declan Joseph. "Studies of the 67 kilodalton laminin receptor in retinal vasculature." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300777.

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Kuroki, Keiichi. "Cellular and extracellular matrix characteristics of canine chondrocytes in pathologic conditions /." Free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091939.

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Books on the topic "Cartilage extracellular matrix (ECM)"

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Arup, Sen, Thornhill Thomas, Johnson & Johnson, inc. Orthopedic Division., and University of California, Los Angeles., eds. Development and diseases of cartilage and bone matrix: Proceedings of a Johnson & Johnson Orthopedic Division-UCLA symposium held at Lake Tahoe, California, March 16-21, 1986. Liss, 1987.

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Goodstone, Nicola Jayne. Cellular responses to components of the extracellular matrix of human articular cartilage in patients with rheumatoid arthritis. University of Manchester, 1994.

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M, Glauert Audrey, Strangeways Research Laboratory (Cambridge, England), and International Symposium on "The Control of Tissue Damage" (1987 : Babraham, England), eds. The Control of tissue damage: Strangeways Research Laboratory 75th anniversary symposium, 6-8 April 1987. Elsevier, 1988.

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Bilezikian, John P., Markus J. Seibel, and Simon P. Robins. Dynamics of Bone and Cartilage Metabolism: Principles and Clinical Applications. Elsevier Science & Technology Books, 2006.

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(Editor), Markus J. Seibel, Simon P. Robins (Editor), and John P. Bilezikian (Editor), eds. Dynamics of Bone and Cartilage Metabolism, Second Edition: Principles and Clinical Applications. 2nd ed. Academic Press, 2006.

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(Editor), Markus J. Seibel, Simon P. Robins (Editor), and John P. Bilezikian (Editor), eds. Dynamics of Bone and Cartilage Metabolism, Second Edition: Principles and Clinical Applications. Academic Press, 2006.

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Regulation of Chondrogenesis in Human Mesenchymal Stem Cells by Cartilage Extracellular Matrix and Therapeutic Applications. [publisher not identified], 2018.

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Lennon, Rachel, and Neil Turner. The molecular basis of glomerular basement membrane disorders. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0320_update_001.

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The glomerular basement membrane (GBM) is a condensed network of extracellular matrix molecules which provides a scaffold and niche to support the function of the overlying glomerular cells. Within the glomerulus, the GBM separates the fenestrated endothelial cells, which line capillary walls from the epithelial cells or podocytes, which cover the outer aspect of the capillaries. In common with basement membranes throughout the body, the GBM contains core components including collagen IV, laminins, nidogens, and heparan sulphate proteoglycans. However, specific isoforms of these proteins are r
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Control of Tissue Damage (Research Monographs in Cell & Tissue Physiology). Elsevier Science Ltd, 2000.

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MacGrogan, Donal, José Maria Pérez-Pomares, Bill Chaudhry, José Luis de la Pompa, and Deborah J. Henderson. From cushions to leaflets: morphogenesis of cardiac atrioventricular valves. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0017.

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At the looping stage of heart development, tissue patterning of myocardium and endocardium at the atrioventricular (AV) junction defines a morphogenic field competent to form valves that initially appear as protrusions of proteoglycan-rich extracellular matrix (ECM) called endocardial cushions (ECs) which are cellularized by an endocardial-mesenchymal transition (EMT). Cellular proliferation results in fusion of the major AV mesenchymal cushions and AV septation, whereas smaller cushions receive a supply from epicardially derived cells. These various sources of mesenchyme precursors give rise
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Book chapters on the topic "Cartilage extracellular matrix (ECM)"

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Helm, Richard F., and Malcolm Potts. "Extracellular Matrix (ECM)." In Ecology of Cyanobacteria II. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-3855-3_18.

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Proske, Uwe, David L. Morgan, Tamara Hew-Butler, et al. "Extracellular Matrix (ECM)." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2389.

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Papanicolaou, Michael, and Thomas R. Cox. "Extracellular Matrix (ECM)." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-21573-6_5691-1.

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Papanicolaou, Michael, and Thomas R. Cox. "Extracellular Matrix (ECM)." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_5691.

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Balasubramanian, Swarnalatha, Elizabeth M. Powell, and Jennie B. Leach. "Investigating Cell-ECM Interactions and ECM Synthesis in Three-Dimensional Hydrogels." In Extracellular Matrix. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2083-9_10.

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Hennen, Eva, and Andreas Faissner. "Modulation of Neural Stem Cell Expressed Extracellular Matrix (ECM) by Targeting Glycosyltransferases." In Extracellular Matrix. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2083-9_13.

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Zhang, Xiaoming, and Michael P. Sarras. "ECM in Hydra Development and Regeneration." In Extracellular Matrix in Development. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-35935-4_7.

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Caravà, Elena, Cristiana Marcozzi, Barbara Bartolini, et al. "Method for Studying ECM Expression: In Situ RT-PCR." In The Extracellular Matrix. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9133-4_2.

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Ghorbani, Farnaz, Niyousha Davari, Chaozong Liu, and Behafarid Ghalandari. "Advances in ECM Protein-Based Materials." In Handbook of the Extracellular Matrix. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-56363-8_11.

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Ghorbani, Farnaz, Niyousha Davari, Chaozong Liu, and Behafarid Ghalandari. "Advances in ECM Protein-Based Materials." In Handbook of the Extracellular Matrix. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-030-92090-6_11-1.

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Conference papers on the topic "Cartilage extracellular matrix (ECM)"

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Langley, Andrew, Allison Sweeney, Christopher Nguyen, Skye Edwards, Deeksha Sankepalle, and Srivalleesha Mallidi. "Non-invasive simultaneous assessment of therapy-induced tumor microenvironmental changes in collagen and vasculature with photoacoustic imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2025. https://doi.org/10.1364/omp.2025.om5e.2.

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The tumor microenvironment (TME) is critical for tumor cell survival and metastasis, comprising both cellular (immune and stromal cells) and non-cellular (extracellular matrix, ECM) components. Collagen within the ECM, produced by cancer-associated fibroblasts, fosters aggressive tumor phenotypes and confers resistance to chemotherapy. To enhance the efficacy of cancer therapies, various innovative strategies are being developed to normalize or target tumor collagen. We have previously demonstrated that photodynamic therapy (PDT) at low doses, termed photodynamic priming (PDP), can degrade col
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Namani, Ravi, Narendra K. Simha, and Jack L. Lewis. "Damage of Articular Cartilage due to Mechanical Fatigue and Collagenase Action." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193211.

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Damage to the extracellular matrix (ECM) of articular cartilage is detrimental to its functional load-bearing properties. Cartilage ECM can be damaged chemically by enzymatic cleavage or mechanically either due to impact loads or long term fatigue loads at physiological levels. There is strong evidence that chronic long term loads in conjunction with chemical weakening can lead to osteoarthritic degeneration of cartilage [1, 2].
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Khoshgoftar, M., W. Wilson, K. Ito, and C. C. van Donkelaar. "Tissue- and Cell-Level Inhomogeneities Significantly Alter the Mechanical Behavior of Tissue-Engineered Cartilage." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80758.

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The insufficient load-bearing capacity of today’s tissue engineered (TE) cartilage is an important limiting factor for its clinical application. It is believed that the mechanical quality of TE cartilage constructs would be optimal if it had both a structure and composition resembling native cartilage. Cartilage TE studies therefore aim to reach extracellular matrix (ECM) content that resembles that of native tissue. However, the correlation between ECM content and mechanical properties of TE constructs is not unique and the correlation between matrix content and mechanical properties vary con
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Mow, V. C., X. E. Guo, D. D. Sun, and W. M. Lai. "Changes in the Mechano-Electrochemical Environment in the Extracellular Matrix Surrounding Chondrocytes." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1932.

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Abstract The objective of this paper is to provide an overall discussion of the biomechanical factors that are required to analyze and interpret data from the explant experiments and to present a description of some of the mechano-electrochemical events in the extracellular matrix (ECM) surrounding chondrocytes occurring within cartilage explants during loading. Five common loading cases of cartilage explants are discussed: hydrostatic pressure, osmotic pressure, permeation, confined compression and unconfined compression. Details of such surface loadings on the internal ECM pressure, fluid an
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Wanich, Tony. "Treatment of Articular Cartilage Injuries in the Knee." In ASME 2009 4th Frontiers in Biomedical Devices Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/biomed2009-83083.

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Articular cartilage is a unique biphasic tissue composed of chondrocytes surrounded by extracellular matrix (ECM). This thin layer of tissue covers the articular surface of diarthroidal joints and provides a durable, low friction interface which also helps to reduce the load transmitted to the underlying subchondral bone.
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Lin, David C., and Ferenc Horkay. "Mapping the Elastic and Osmotic Properties of Cartilage Extracellular Matrix." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206312.

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The inhomogeneous distribution of crosslinks in polymer networks results in nonuniform swelling. Concomitant with this behavior is local variability in the elastic properties of synthetic and biopolymer gels. Articular cartilage exemplifies the compositional and structural complexities found in soft tissues. At the most basic level, cartilage extracellular matrix (ECM) is a relatively stiff network of collagen type II fibers with entangled hyaluronic acid chains and enmeshed aggrecan molecules. Despite significant differences in composition, synthetic and biological gels exhibit qualitatively
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Natoli, Roman M., and Kyriacos A. Athanasiou. "Ameliorating Glycosaminoglycan (GAG) Loss and Cell Death in Articular Cartilage Following Single-Impact Loading." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176542.

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Impact loading of articular cartilage leads to post-traumatic osteoarthritis (OA) through its effects on the cells and extracellular matrix (ECM) of the tissue. Studies have shown the level of impact or injurious compression correlates with increased cell death, degradation of the ECM, and detrimental changes in biomechanical properties [1]. Recently, several bioactive agents, such as P188 and IGF-I, have shown promising results by reducing cell death following injurious compression of cartilage explants [2, 3].
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Sun, D. D., V. C. Mow, W. M. Lai, and X. E. Guo. "Depth-Dependent Material Property Inhomogeneities Affect the Deformation and Electric Fields in the Chondrocytes and Extracellular Matrix During Compression." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23059.

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Abstract The biosynthetic activities of chondrocytes are regulated by the mechanical and electrochemical (MEC) environments around cells in the extracellular matrix (ECM) such as matrix deformation, stress/strain, fluid and osmotic pressures and electrical potential [e.g., 1–3]. These MEC parameters are the signals that chondrocytes sense and respond to under mechanical or chemical loading. Therefore, detailed quantification of these MEC signals is a key step toward the understanding the mechano-signal transduction mechanism in cartilage. Since microscopic measurements of MEC environments arou
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Wilusz, Rebecca E., Eric M. Darling, Michael P. Bolognesi, Stefan Zauscher, and Farshid Guilak. "The Inhomogeneous Mechanical Properties of the Pericellular Matrix of Articular Cartilage Measured In Situ by Atomic Force Microscopy." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206403.

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Articular cartilage is the connective tissue that lines the articulating surfaces of diarthrodial joints, providing a low-friction, load-bearing surface during joint motion. Articular cartilage comprises of a single cell type, the chondrocyte, embedded within an extensive extracellular matrix (ECM). Each chondrocyte is surrounded by a narrow region called the pericellular matrix (PCM) that is distinct from the ECM in both its biochemical composition [1] and biomechanical properties [2]. While multiple techniques have been used to measure the mechanical properties of the PCM, including micropip
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Vandenberg, Theodore W., Christopher R. Nehme, and Thomas P. James. "Application of Microforming to Create Chondrocyte Home Sites in a Natural Cartilage Matrix." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-36953.

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Articular cartilage degeneration is a central pathological feature of osteoarthritis. Cartilage in the adult does not regenerate in vivo and, as a result, cartilage damage in osteoarthritis is irreversible. With our ever-aging population, osteoarthritis has become a leading cause of disability and unfortunately, no optimal treatments for osteoarthritis are currently available. To address this problem, a research community is focused on the development of both natural and synthetic biodegradable tissue scaffolds. The scaffolds must contain depressions or holes for the purpose of chondrocyte see
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Reports on the topic "Cartilage extracellular matrix (ECM)"

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Cao, Siyang, Yihao Wei, Huihui Xu, et al. Crosstalk between Ferroptosis and Chondrocytes in Osteoarthritis: A Systematic Review of in-vivo and in-vitro Studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.3.0044.

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Review question / Objective: For the sake of better apprehending the nexus between ferroptosis and chondrocytes in osteoarthritis (OA), proffering novel insights and opening-up new orientation for in-depth research in both pre-clinical and clinical settings, it is warranted to initiate one rigorous and robust systematic review (SR) based upon up-to-date in-vivo and in-vitro research advances on this topic. To the best our knowledge, no SRs concerning ferroptosis and chondrocytes in OA have been published thus far. Condition being studied: Osteoarthritis (OA) is the most common form of arthriti
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Barash, Itamar, J. Mina Bissell, Alexander Faerman, and Moshe Shani. Modification of Milk Composition via Transgenesis: The Role of the Extracellular Matrix in Regulating Transgene Expression. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570558.bard.

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Altering milk composition via transgenesis depends on three main factors. (1) The availability of an efficient regulatory sequences for targeting transgene(s) to the mammary gland; (2) a reliable in vitro model to test the expression of transgenes prior to their introduction to the animal genome; and (3) better understanding of the major factors which determine the rate of gene expression and protein synthesis. The current studies provide the necessary means and knowledge to alter milk protein composition via transgenesis. The following specific goals were achieved: a: Identifying regulatory r
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Osathanon, Thanaphum. Gene expression profile of continuous and intermittent compressive stress treated human periodontal ligament cells. Faculty of Dentistry Chulalongkorn University, 2019. https://doi.org/10.58837/chula.res.2019.7.

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Mechanical force regulates periodontal ligament cell (PDL) behavior. However, different force types lead to distinct PDL responses. Here, we report that pretreatment with an intermittent compressive force (ICF), but not a continuous compressive force (CCF), promoted human PDL (hPDL) osteogenic differentiation as determined by osteogenic marker gene expression and mineral deposition in vitro. ICF-induced osterix (OSX) expression was inhibited by cycloheximide and monensin. Although CCF and ICF significantly increased extracellular adenosine triphosphate (ATP) levels, pretreatment with exogenous
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