Log in

Relevant bibliographies by topics / Cartilage extracellular matrix (ECM) / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Cartilage extracellular matrix (ECM).

Dissertations / Theses on the topic 'Cartilage extracellular matrix (ECM)'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Cartilage extracellular matrix (ECM).'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Kuaha, Kunnika. "Environments for zonal cartilage tissue engineering." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/81992/1/Kunnika_Kuaha_Thesis.pdf.

Full text

Abstract:

Articular cartilage is a highly organized tissue with cellular and matrix properties that vary with depth zones. Regenerating this zonal organization has proven difficult in tissue-engineered cartilage to treat damaged cartilage. In this thesis, we evaluated the effects of culture environments that mimic aspects of the native cartilage environment on chondrocyte subpopulations. We found that decellularized cartilage matrix can improve zonal tissue-engineered cartilage. Also, chondrocytes respond to signals from bone cells and compressive stimulation in a zone-dependent manner. These results hi

APA, Harvard, Vancouver, ISO, and other styles

2

Han, Lin Ph D. Massachusetts Institute of Technology. "Nanomechanics of cartilage extracellular matrix macromolecules." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42134.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.<br>Includes bibliographical references (p. 187-201).<br>In this thesis, the shear and self-adhesion nanomechanical properties between opposing cartilage aggrecan macromolecules were probed. In addition, nanoscale dynamic oscillatory mechanical properties of cartilage and its type II collagen network was measured. Aggrecan shear nanomechanics was assessed via microcontact printing and lateral force microscopy. Lateral force between aggrecan and the probe tip, and compression of aggrecan was

APA, Harvard, Vancouver, ISO, and other styles

3

Kammerer, Theresa Anne [Verfasser], and Sebastian Johannes [Akademischer Betreuer] Arnold. "Visualization of the Extracellular Matrix (ECM) by fluorescent tagging of ECM components in mouse." Freiburg : Universität, 2021. http://d-nb.info/1232644803/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Randles, Michael. "Proteomic analyses of kidney glomerular extracellular matrix in health and disease." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/proteomic-analyses-of-kidney-glomerular-extracellular-matrix-in-health-and-disease(a39fe408-db06-4d80-b97b-4e0651bf7bc3).html.

Full text

Abstract:

Glomerular filtration is a vital physiological process removing waste products from the circulation and this process occurs across the glomerular filtration barrier (GFB). The cells and extracellular matrix (ECM), which form this barrier, are exposed to forces during ultrafiltration and special adaptation is required to withstand these forces. Dysfunction in cellular adhesion machinery or ECM assembly within the GFB causes loss of selective glomerular filtration, however, the mechanisms governing these processes are poorly understood. To this end we sought to characterise the glomerular ECM an

APA, Harvard, Vancouver, ISO, and other styles

5

Marengo, Kaitlyn A. "The Incorporation of Decellularized Cardiac ECM into Fibrin Microthreads." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/843.

Full text

Abstract:

Stem cell therapies have shown promising capabilities in regaining the functionality of scar tissue following a myocardial infarction. Biological sutures composed of fibrin have been shown to more effectively deliver human mesenchymal stem cells (hMSCs) to the heart when compared to traditional cell delivery mechanisms. While the biological sutures do show promise, improvements can be made. To enhance the fibrin sutures, we propose to incorporate native cardiac extracellular matrix (ECM) into the fibrin microthreads to produce a more in vivo-like environment. This project investigated the effe

APA, Harvard, Vancouver, ISO, and other styles

6

Villaggio, Giusy. "Relationship between extracellular matrix (ECM) components and mineralization in bone marrow stromal cells." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1492.

Full text

Abstract:

The relations between cells and extracellular matrix seem to orchestrate tissue organization by regulating cell functions during fetal development and throughout normal adult life. Thus, focusing on the innate ability of the native ECM to better modulate cell behavior, the coating of synthetic biomaterials with cell-derived decellularized extracellular matrices is a promising approach to confer bioactivity to inert materials and direct the fate of host or transplanted cells in tissue engineering applications. This study aims to better understand ECM influence on human bone marrow stem cells an

APA, Harvard, Vancouver, ISO, and other styles

7

Kwak, Hyo Bum. "Exercise training regulation of extracellular matrix and remodeling in the aging rat heart." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2761.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Hancock, Sian. "Ultrastructural organisation and molecular interactions in the hypertrophic cartilage extracellular matrix." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55149/.

Full text

Abstract:

Type X collagen is a member of the family of network-forming collagens, it contains a triple helical domain flanked by two non-collagenous (NC) domains, NC2 at the N-terminal and NCI at the C-terminal. It is expressed and synthesised by hypertrophic chondrocytes of the epiphyseal growth plates during the process of endochondral ossification (EO). This process involves replacement of a cartilaginous anlagen by bone, the coordination of chondrocyte proliferation, maturation and hypertrophy are followed by calcification of hypertrophic cartilage, vascular invasion and deposition of a bone matrix.

APA, Harvard, Vancouver, ISO, and other styles

9

McKenna, Declan Joseph. "Studies of the 67 kilodalton laminin receptor in retinal vasculature." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300777.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Kuroki, Keiichi. "Cellular and extracellular matrix characteristics of canine chondrocytes in pathologic conditions /." Free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091939.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Singh, Mahipal, Cerrone R. Foster, Suman Dalal, and Krishna Singh. "Osteopontin: Role in Extracellular Matrix Deposition and Myocardial Remodeling Post-MI." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/8576.

Full text

Abstract:

Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and

APA, Harvard, Vancouver, ISO, and other styles

12

Brian, Irene. "Crosstalk between ECM mechanical cues and cellular metabolism." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422721.

Full text

Abstract:

Mechanical cues coming from the extracellular matrix (ECM) are key factors in the control of tissue homeostasis in physiology and disease. Cells can sense these physical cues and measure external resisting forces by adjusting their actomyosin cytoskeleton, which in turn regulates intracellular signalling pathways to orchestrate a proper cell response. Thus, ECM stiffness is important for many biological aspects such as proliferation, differentiation and migration. Very little is known instead, about its impact on cellular metabolism, and the molecular players involved in this process are large

APA, Harvard, Vancouver, ISO, and other styles

13

Seyfried, Nicholas T. "The structure and function of hyaluronan-binding proteins in extracellular matrix assembly." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:e1a2cf8f-7ac7-4c5a-bd3f-53d7653e8888.

Full text

Abstract:

The chondroitin sulfate proteoglycan (CSPG) aggrecan forms link protein-stabilised complexes with hyaluronan (HA), via its N-terminal G1-domain, that provide cartilage with its load bearing properties. Similar aggregates (potentially containing new members of the link protein family), in which other CSPGs (i.e., versican, brevican and neurocan) substitute for aggrecan, may contribute to the structural integrity of many other tissues including skin and brain. In this thesis, cartilage link protein (cLP) and the G1-domains of aggrecan (AG1) and versican (VG1) were expressed in Drosophila S2 cell

APA, Harvard, Vancouver, ISO, and other styles

14

Rice, Mark Andrew. "PEG-based hydrogels as chondrocyte carriers for tissue engineered cartilage: Controlling extracellular matrix evolution and integration with native cartilage." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3207731.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Jovanovic, Ivana. "Towards the development of bioartificial cartilage : metabolic and extracellular matrix production activities of chondrocytes." Thesis, Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/11252.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Davidson, David 1963. "Interactive signalling by growth factors and extracellular matrix molecules in cartilage development and metabolism." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102493.

Full text

Abstract:

Articular cartilage reduces friction and absorbs shock protecting the moving ends of bones from damage during normal physical activity. These mechanical properties of cartilage result from the physiological activities of chondrocytes, the phenotypically unique cells that produce and maintain the cartilage matrix. The behaviour of these cells is controlled by extracellular milieu components including: matrix molecules, growth factors, calcium and phosphorus. The interaction of these signals maintains the homeostatic balance between anabolism and catabolism in healthy articular cartilage. Unimpe

APA, Harvard, Vancouver, ISO, and other styles

17

Breinan, Howard Alan 1968. "Development of a collagen-glycosaminoglycan analog of extracellular matrix to facilitate articular cartilage regeneration." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/49641.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1998.<br>Includes bibliographical references (leaves 205-220).<br>by Howard Alan Breinan.<br>Ph.D.

APA, Harvard, Vancouver, ISO, and other styles

18

Siu, Kwan-yee Michelle, and 蕭君兒. "How do components of the extracellular matrix (ECM) regulate junction dynamics in the testis and their implication in contraceptivedevelopment?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31244749.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Kuroda, Mito. "Mechanism of the ECM stiffness-dependent differentiation of mesenchymal stem cells." Kyoto University, 2018. http://hdl.handle.net/2433/232360.

Full text

Abstract:

Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21159号<br>農博第2285号<br>新制||農||1060(附属図書館)<br>学位論文||H30||N5133(農学部図書室)<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授阪井康能, 教授矢﨑一史<br>学位規則第4条第1項該当

APA, Harvard, Vancouver, ISO, and other styles

20

Gnanasambandam, Bhargavee. "Design of Modified Traction Force Microscopy for Cell Response to De Novo ECM." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1591698756910799.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Chin, LiKang. "Tyramine Substituted-Hyaluronan Enriched Fascia for Rotator Cuff Tendon Repair." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1291410773.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Jones, Caitlin. "Stromal PTEN Expression Regulates Extracellular Matrix Deposition and Organization in the Mammary Gland." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1585750384613682.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Pershouse, David A. "Effect of decellularisation methods on methacryloyl-substituted placental ECM hydrogels." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/201712/1/David_Pershouse_Thesis.pdf.

Full text

Abstract:

Biomedical research uses hydrogels for cell culture to closely mimic cellular environments and produce more accurate results than traditional methods. Here, human placenta, a tissue rich in bio-signalling molecules, is used as a base material to create a novel type of hydrogel that can be cured by exposure to visible light (Placental-Methacryloyl; PlacMA). Effects of different preparation methods are explored while mechanical, chemical and biological properties of PlacMA are investigated. PlacMA was found to be highly tuneable and suitable for a variety of cell culture and tissue engineering a

APA, Harvard, Vancouver, ISO, and other styles

24

Reynolds, Scott. "Investigating the relationship between proteoglycan sulfation state and extracellular matrix signalling in the developing zebrafish cartilage." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715795.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Aulin, Cecilia. "Extracellular Matrix Based Materials for Tissue Engineering." Doctoral thesis, Uppsala universitet, Institutionen för materialkemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110631.

Full text

Abstract:

The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. By culturing cells on polymer meshes under dynamic culture conditions, deposition of a complex ECM could be achieved, but with low yields. Since the major part of synthesized ECM diffused into the medium the rate limiting step of deposition was investigated. This quantit

APA, Harvard, Vancouver, ISO, and other styles

26

Burrows, Mariana Carvalho. "Evaluation of electrospun PLLA-ECM scaffolds as biomaterials for bone regeneration." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-14092016-090552/.

Full text

Abstract:

The extracellular matrix (ECM) is secreted by the host tissue and is an important key for mechanisms of cell responses. The main properties of the ECM materials include biodegradability, biocompatibility, and nanostructured in a 3D fibre network. In addition, ECM is composed of important molecules like growth factors, glycosaminoglycans (GAGs), collagens, fibronectin, and lamin, while final composition depends on the native tissue. We have selected for this study ECMs from cortical bone (B-ECM) and pericardium (P-ECM) tissue. These ECMs were digested by collagenase, pepsin and trypsin. Each of

APA, Harvard, Vancouver, ISO, and other styles

27

Liu, Hongxiang. "Effects of pulsed electromagnetic fields on extracellular matrix composition of embryonic chick sternal cartilage explanted to culture." Thesis, Royal Veterinary College (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362746.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Nugent, Ashleigh Elizabeth. "The Presence of Extracellular Matrix Alters the Chondrocyte Response to Endoplasmic Reticulum Stress." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271375344.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Reisbig, Nathalie A. "Synovial Extracellular Matrix and Synovial Mesenchymal Stem Cells are Chondrogenic In Vitro and In Vivo." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543150403002824.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Durigova, Michaela. "Mechanisms of proteoglycan aggregate degradation in cytokine-stimulated cartilage." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111912.

Full text

Abstract:

Aggrecan is one of the most important structural components of the extracellular matrix (ECM) of articular cartilage, where it contributes to the hydration of the tissue and its ability to resist compressive loads during joint movement. Increased aggrecan degradation and loss occurs in joint diseases and is thought to be mediated by enzymes such as the matrix metalloproteinases (MMPs) and aggrecanases (ADAMTS). It has also been proposed that aggrecan release from the cartilage can be mediated by a non-proteolytic mechanism which involves the degradation of hyaluronan (RA) to which the aggrecan

APA, Harvard, Vancouver, ISO, and other styles

31

Jakkula, E. (Eveliina). "Defects in the genes coding for cartilage extracellular matrix proteins as a cause of osteoarthritis and multiple epiphyseal dysplasia." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277333.

Full text

Abstract:

Abstract The role of sequence variations in genes encoding cartilage extracellular matrix (ECM) proteins were studied in osteoarthritis (OA) and multiple epiphyseal dysplasia (MED). The cartilage collagen genes COL2A1, COL9A1, COL9A2, COL9A3, COL11A1, and COL11A2 were screened for sequence variations in 72 Finnish probands and one US family with primary early-onset hip and/or knee OA. Altogether 239 sequence variations were found, of which 16 were not present in the controls. Seven of the unique variations — four in COL11A1, two in COL11A2, and one in COL2A1 — were studied further, because the

APA, Harvard, Vancouver, ISO, and other styles

32

Ghanavi, Parisa. "Effects of cartilage dust on cartilage formation in in vitro and in ectopic in vivo models." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/101499/1/Parisa_Ghanavi_Thesis.pdf.

Full text

Abstract:

This thesis is a comparative study of cartilage tissue regeneration by the tissue’s resident cells with or without adding the tissue matrix’s particles, in the lab and followed by implantation in mouse. Incorporation of the particles with the cells appears to be a viable strategy to increase the cartilage-like matrix content in the short-term, and the particles appear to integrate into the regenerated tissue in the long-term.

APA, Harvard, Vancouver, ISO, and other styles

33

Alamein, Mohammad A. "Guiding Stem Cells for Tissue and Organ Engineering: Clinical Grade Nanofiber Electrospinning for Recreation of the Optimal 3-Dimensional Extracellular Niche to Control Cellular Fate." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/367480.

Full text

Abstract:

We aimed to provide optimal and controlled growth mechanisms that determine the fate of cells by designing a novel polymeric, bio-functionalised 3-dimensional artificial Nanofibrous Extracellular Matrix (NF-ECM) that recapitulates the natural microenvironment of cells. We initially reviewed current cell-expansion methods, and clinically feasible protocols for tissue engineering applications. They are often based on conventional 2-dimensional tissue culture plates that usually require xenogenic coating substrates or feeder-cells to maintain their characteristics. Propagating cells in a 3-dimens

APA, Harvard, Vancouver, ISO, and other styles

34

Antoine, Elizabeth Elena. "Mechanics and transport characterization of bioengineered tissue microenvironment platforms." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/56954.

Full text

Abstract:

The tissue microenvironment is a complex living system containing heterogeneous mechanical and biophysical cues. Cellular components are surrounded by extracellular matrix and interstitial fluid, while transport of nutrients and biochemical factors is achieved via the vasculature. Each constituent of the tissue microenvironment can play a significant role in its ability to function normally. Many diseases including cancer have been linked with dysfunction in the tissue microenvironment; therefore an improved understanding of interaction between components of this complex system is needed. In

APA, Harvard, Vancouver, ISO, and other styles

35

Antoine, Elizabeth E. "Mechanics and transport characterization of bioengineered tissue microenvironment platforms." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/56954.

Full text

Abstract:

The tissue microenvironment is a complex living system containing heterogeneous mechanical and biophysical cues. Cellular components are surrounded by extracellular matrix and interstitial fluid, while transport of nutrients and biochemical factors is achieved via the vasculature. Each constituent of the tissue microenvironment can play a significant role in its ability to function normally. Many diseases including cancer have been linked with dysfunction in the tissue microenvironment; therefore an improved understanding of interaction between components of this complex system is needed. I

APA, Harvard, Vancouver, ISO, and other styles

36

Jaabar, Ilhem Lilia. "Surface characterizations to investigate osteoarticular mesenchymal tissues : new insights to monitor the extracellular matrix remodeling at the supramolecular level." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS145.pdf.

Full text

Abstract:

Un tissu conjonctif est un ensemble coopératif de cellules différenciées enchevêtrées dans une matrice extracellulaire (ECM). Cette dernière, particulièrement abondante, se compose principalement de protéines, telles que les collagènes, et d'un gel visqueux constitué d'eau et de protéoglycanes chargés négativement. Tous les tissus conjonctifs subissent un renouvellement constant de leur ECM, préservant ainsi l'intégrité et les propriétés des tissus. Des perturbations dans le remodelage de l'ECM, en termes de composition ou de structure supramoléculaire, peuvent avoir un impact significatif sur

APA, Harvard, Vancouver, ISO, and other styles

37

Vogel, Sarah, Simon Arnoldini, Stephanie Möller, Ute Hempel, and Matthias Schnabelrauch. "Sulfated hyaluronan alters fibronectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-221028.

Full text

Abstract:

Extracellular matrix (ECM) composition and structural integrity is one of many factors that influence cellular differentiation. Fibronectin (FN) which is in many tissues the most abundant ECM protein forms a unique fibrillary network. FN homes several binding sites for sulfated glycosaminoglycans (sGAG), such as heparin (Hep), which was previously shown to influence FN conformation and protein binding. Synthetically sulfated hyaluronan derivatives (sHA) can serve as model molecules with a well characterized sulfation pattern to study sGAG-FN interaction. Here is shown that the low-sulfated sHA

APA, Harvard, Vancouver, ISO, and other styles

38

Palmer, Ashley Wells. "Investigations of the Composition-Function Relationships in Normal, Degraded, and Engineered Articular Cartilage Using Epic-Microcomputed Tomography." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14572.

Full text

Abstract:

Articular cartilage provides a low-friction surface during normal joint motion and distributes forces to the underlying bone. The extracellular matrix (ECM) composition of healthy cartilage has previously been shown to be an excellent predictor of its mechanical properties. Changes in ECM composition and loss of mechanical function are known to occur with degenerative conditions such as osteoarthritis. Identifying differences in the composition-function relationships of cartilage under different anabolic, catabolic, and homeostatic conditions may thus be a useful approach for identifying facto

APA, Harvard, Vancouver, ISO, and other styles

39

Li, Ping [Verfasser], and Attila [Akademischer Betreuer] Aszódi. "The roles of extracellular matrix molecules matrilins and aggrecan in bone development and articular cartilage functions / Ping Li ; Betreuer: Attila Aszódi." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1221699199/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Knapp, Danielle Careen. "The Extraction of Type II Collagen and the Electrospinning of Nano-Fibrous Scaffolds." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/928.

Full text

Abstract:

Articular cartilage lining joints, such as in the knee, functions to reduce friction and absorb shock. Collagen type II is the largest constituent in the extracellular matrix of articular cartilage and its restoration is of the highest interest to tissue engineers. Cartilage has little ability to naturally regenerate due to the absence of vascularity and the inability of the chondrocytes to proliferate at a high rate. It would be ideal to create a mimicking extracellular matrix/scaffold from type II collagen that could possibly be used to replace damaged articular cartilage that has the same f

APA, Harvard, Vancouver, ISO, and other styles

41

Ndreu, Albana. "Electrospun Nanofibrous Scaffolds For Tissue Engineering." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608226/index.pdf.

Full text

Abstract:

In this study a microbial polyester, poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV), and its blends were wet or electrospun into fibrous scaffolds for tissue engineering. Wet spun fiber diameters were in the low micrometer range (10-50 &amp<br>#956<br>m). The polymer concentration and the stirring rate affected the properties the most. The optimum concentration was determined as 15% (w/v). Electrospun fiber diameters, however, were thinner. Solution viscosity, potential, distance between the syringe tip and the collector, and polymer type affected the morphology and the thickness of bead

APA, Harvard, Vancouver, ISO, and other styles

42

Foulcer, Simon. "Structural and functional studies on the G1 domain of human versican." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/structural-and-functional-studies-on-the-g1-domain-of-human-versican(2670c4da-7050-4280-8a7c-fc02ab3e8bb3).html.

Full text

Abstract:

The chondroitin sulphate proteoglycan (CSPG) versican forms complexes with hyaluronan (HA), which are essential in a range of functions including cellular proliferation and migration. Four isoforms of versican result from alternative splicing. Furthermore, biological roles have been identified for the proteolytic cleavage product of versican which contains the N-terminal G1 hyaluronan binding domain. All of these versican forms have different tightly regulated tissue expression profiles. Consequently, impaired regulation is associated with a number of disease pathologies. For example the large

APA, Harvard, Vancouver, ISO, and other styles

43

Vogel, Sarah, Simon Arnoldini, Stephanie Möller, Ute Hempel, and Matthias Schnabelrauch. "Sulfated hyaluronan alters fibronectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells." Nature Publishing Group, 2016. https://tud.qucosa.de/id/qucosa%3A29174.

Full text

Abstract:

Extracellular matrix (ECM) composition and structural integrity is one of many factors that influence cellular differentiation. Fibronectin (FN) which is in many tissues the most abundant ECM protein forms a unique fibrillary network. FN homes several binding sites for sulfated glycosaminoglycans (sGAG), such as heparin (Hep), which was previously shown to influence FN conformation and protein binding. Synthetically sulfated hyaluronan derivatives (sHA) can serve as model molecules with a well characterized sulfation pattern to study sGAG-FN interaction. Here is shown that the low-sulfated sHA

APA, Harvard, Vancouver, ISO, and other styles

44

Hansen, Ryan. "Functional and Structural Analysis of Decellularized Liver Tissue Matrix, with Potential Applications in Cancer Tissue Engineering." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1498650461817088.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Shelper, Todd Benjamin. "Exploring Morphology and Drug Interactions in Pancreatic Cancer with 3D Cell Culture." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/367976.

Full text

Abstract:

Pancreatic cancer continues to have one of the poorest prognoses amongst all cancers, with a 95% mortality rate. Standard of care chemotherapy has failed to provide significant clinical benefits, which has led to the development of targeted agents against validated signalling pathways. However, to date the approach of targeted agents alone, or in combination with traditional chemotherapeutics, has failed to significantly improve the prognosis for pancreatic cancer patients. The current standard of care chemotherapy for advanced pancreatic cancer provides only a modest increase in survival of s

APA, Harvard, Vancouver, ISO, and other styles

46

Veyssiere, Alexis. "De la décellularisation de cartilage de porc à la chondrogenèse auriculaire." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC408.

Full text

Abstract:

Les reconstructions auriculaires représentent un réel défi pour le chirurgien. Plusieurs techniques existent présentant chacune des inconvénients non négligeables.L’essor de l’ingénierie tissulaire des 20 dernières années ouvre la possibilité à de nouvelles thérapeutiques.L’ingénierie du cartilage ne déroge pas à la règle et connaît une sérieuse évolution, concernant le cartilage articulaire mais également les autres types de cartilages dont le cartilage auriculaire.Appliquées à la reconstruction auriculaire, ces techniques apportent du tissu cartilagineux tout en minorant les effets secondair

APA, Harvard, Vancouver, ISO, and other styles

47

Connelly, John Thomas. "Regulatory Mechanisms in the Chondrogenesis of Mesenchymal Progenitors: The Roles of Cyclic Tensile Loading and Cell-Matrix Interactions." Diss., Available online, Georgia Institute of Technology, 2007, 2007. http://etd.gatech.edu/theses/available/etd-06132007-115423/.

Full text

Abstract:

Thesis (Ph. D.)--Mechanical Engineering, Georgia Institute of Technology, 2008.<br>Barbara D. Boyan, Committee Member ; Ravi Bellamkonda, Committee Member ; Joseph Le Doux, Committee Member ; Andres J. Garcia, Committee Member ; Marc E. Levenston, Committee Chair.

APA, Harvard, Vancouver, ISO, and other styles

48

Marumoto, Ariane. "Complexo Quinômico envolvido com adaptação de osteoblasto em scaffold orgânico sob condição de diferenciação celular." Botucatu, 2016. http://hdl.handle.net/11449/143761.

Full text

Abstract:

Orientador: Willian Fernando Zambuzzi<br>Resumo: Modelos in vitro têm facilitado a análise da fisiologia celular sob condições experimentais diversas; trata-se de modelo alternativo ao uso de animais de experimentação, que vem sendo difundido e aceito amplamente em pesquisa científica. Além disso, estes modelos têm levado à avanços significativos na compreensão das interações mútuas e adaptativas entre células e substratos. Neste trabalho, nosso objetivo foi analisar eventos moleculares responsáveis pela adaptação de preosteoblastos em substrato orgânico composto por componentes da Matriz Extr

APA, Harvard, Vancouver, ISO, and other styles

49

Hammad, Mira. "Reconstruction of auricular cartilage using natural-derived scaffolds with an in vivo application in rabbit model Effects of hypoxia on chondrogenic differentiation of progenitor cells from different origins Cell sheets as tools for ear cartilage reconstruction in vivo Cartilage tissue engineering using apple cellulosic scaffolds Cell-secreted matrices as cell supports: Novel approaches for cell culture applications." Thesis, Normandie, 2021. http://www.theses.fr/2021NORMC404.

Full text

Abstract:

La reconstruction des défauts du cartilage auriculaire nécessite une restauration appropriée par des sources cellulaires adéquates ainsi que la fourniture de supports appropriés pour les tissus. Ce travail visait à étudier différents échafaudages et biomatériaux pour l'ingénierie in vitro du cartilage auriculaire ainsi que la réparation in vivo du cartilage auriculaire chez des modèles de lapin. Nous avons d'abord montré que les périchondrocytes auriculaires sont les meilleurs candidats pour la régénération du cartilage auriculaire et que l'hypoxie n'est pas nécessaire à leur différenciation c

APA, Harvard, Vancouver, ISO, and other styles

50

McCosker, Helen Clare. "Prognostic significance of IGF and ECM induced signalling proteins in breast cancer patients." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53580/1/Helen_McCosker_Thesis.pdf.

Full text

Abstract:

Breast cancer is a leading contributor to the burden of disease in Australia. Fortunately, the recent introduction of diverse therapeutic strategies have improved the survival outcome for many women. Despite this, the clinical management of breast cancer remains problematic as not all approaches are sufficiently sophisticated to take into account the heterogeneity of this disease and are unable to predict disease progression, in particular, metastasis. As such, women with good prognostic outcomes are exposed to the side effects of therapies without added benefit. Furthermore, women with aggres

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!