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Journal articles on the topic 'Cartilage extracellular matrix (ECM)'

Author: Grafiati

Published: 11 December 2022

Last updated: 31 July 2025

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1

Vertel, B. M. "The Formation of Cartilage Extracellular Matrix." Proceedings, annual meeting, Electron Microscopy Society of America 46 (1988): 230–31. http://dx.doi.org/10.1017/s0424820100103218.

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Normal cartilage function is dependent upon the unique structural properties of the extensive extracellular matrix (ECM). In final assembled form, the ECM of hyaline cartilage is composed of abundant amounts of proteoglycan (PG) and type II collagen. Additional collagens and glycoproteins may be important structural components as well. Through their concentration of negative charges, PGs confer upon the cartilage ECM the ability to retain high levels of hydration and thereby resist compression. Type II collagen fibers contribute to the tensile strength of cartilage.In the cartilage ECM, PG mon

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Roncada, T., and D. J. Kelly. "DEVELOPMENT OF PHOTO-CROSSLINKABLE DECELLULARIZED EXTRACELLULAR MATRIX HYDROGELS FOR CARTILAGE TISSUE ENGINEERING." Orthopaedic Proceedings 106-B, SUPP_2 (2024): 79. http://dx.doi.org/10.1302/1358-992x.2024.2.079.

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Cartilage lacks the ability to self-repair when damaged, which can lead to the development of degenerative joint disease. Despite intensive research in the field of cartilage tissue engineering, there is still no regenerative treatment that consistently promotes the development of hyaline cartilage. Extracellular matrix (ECM) derived hydrogels have shown to support cell adhesion, growth and differentiation [1,2]. In this study, porcine articular cartilage was decellularized, solubilised and subsequently modified into a photo-crosslinkable methacrylated cartilage ECM hydrogel. Bone marrow deriv

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Ocken, Alexander R., Madeline M. Ku, Tamara L. Kinzer-Ursem, and Sarah Calve. "Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development." Molecular & Cellular Proteomics 19, no. 7 (2020): 1220–35. http://dx.doi.org/10.1074/mcp.ra120.001998.

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Perlecan is a critical proteoglycan found in the extracellular matrix (ECM) of cartilage. In healthy cartilage, perlecan regulates cartilage biomechanics and we previously demonstrated perlecan deficiency leads to reduced cellular and ECM stiffness in vivo. This change in mechanics may lead to the early onset osteoarthritis seen in disorders resulting from perlecan knockdown such as Schwartz-Jampel syndrome (SJS). To identify how perlecan knockdown affects the material properties of developing cartilage, we used imaging and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to study the

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Huber, Jessica E., Alan Spievack, Robert L. Ringel, Abby Simmons-Byrd, and Stephen Badylak. "Extracellular Matrix as a Scaffold for Laryngeal Reconstruction." Annals of Otology, Rhinology & Laryngology 112, no. 5 (2003): 428–33. http://dx.doi.org/10.1177/000348940311200508.

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Porcine-derived xenogeneic extracellular matrix (ECM) has been successfully used as a scaffold for tissue repair and reconstruction in numerous preclinical animal studies and human applications. These scaffolds are completely and rapidly degraded and replaced by host-derived tissues that frequently mimic the original tissue composition and architecture. The purpose of the present study was to examine the morphology of ECM scaffolds after their use for laryngeal reconstruction. Thirty adult female dogs were subjected to a partial hemilaryngectomy. The right thyroid cartilage and vocal fold were

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Georgieva, Veronika S., Julia Etich, Björn Bluhm, et al. "Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage." International Journal of Molecular Sciences 21, no. 11 (2020): 4112. http://dx.doi.org/10.3390/ijms21114112.

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MicroRNAs (miRNAs) regulate cartilage differentiation and contribute to the onset and progression of joint degeneration. These small RNA molecules may affect extracellular matrix organization (ECM) in cartilage, but for only a few miRNAs has this role been defined in vivo. Previously, we showed that cartilage-specific genetic ablation of the Mirc24 cluster in mice leads to impaired cartilage development due to increased RAF/MEK/ERK pathway activation. Here, we studied the expression of the cluster in cartilage by LacZ reporter gene assays and determined its role for extracellular matrix homeos

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Gao, Yue, Shuyun Liu, Jingxiang Huang, et al. "The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/648459.

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Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. Cell signaling through integrins regulates several chondrocyte functions, including differentiation, metabolism, matrix remodeling, responses to mechanical stimulation, and cell survival

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Peng, Gordon, Sean M. McNary, Kyriacos A. Athanasiou, and A. Hari Reddi. "Superficial Zone Extracellular Matrix Extracts Enhance Boundary Lubrication of Self-Assembled Articular Cartilage." CARTILAGE 7, no. 3 (2015): 256–64. http://dx.doi.org/10.1177/1947603515612190.

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Objective Previous work has shown that increasing the production of boundary lubricant, superficial zone protein (SZP), did not reduce the friction coefficient of self-assembled articular cartilage constructs and was possibly due to poor retention of the lubricant. The aim of this investigation was to reduce the friction coefficient of self-assembled articular cartilage constructs through enhancing SZP retention by the exogenous addition of extracellular matrix (ECM) extracted from the superficial zone of native articular cartilage. Design Superficial zone cartilage was shaved from juvenile bo

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Mariadoss, Arokia Vijaya Anand, and Chau-Zen Wang. "Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions." International Journal of Molecular Sciences 24, no. 19 (2023): 14895. http://dx.doi.org/10.3390/ijms241914895.

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The tyrosine kinase family receptor of discoidin domain receptors (DDR1 and DDR2) is known to be activated by extracellular matrix collagen catalytic binding protein receptors. They play a remarkable role in cell proliferation, differentiation, migration, and cell survival. DDR1 of the DDR family regulates matrix-metalloproteinase, which causes extracellular matrix (ECM) remodeling and reconstruction during unbalanced homeostasis. Collagenous-rich DDR1 triggers the ECM of cartilage to regenerate the cartilage tissue in osteoarthritis (OA) and temporomandibular disorder (TMD). Moreover, DDR2 is

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Gilbert, Sophie Jane, Cleo Selina Bonnet, and Emma Jane Blain. "Mechanical Cues: Bidirectional Reciprocity in the Extracellular Matrix Drives Mechano-Signalling in Articular Cartilage." International Journal of Molecular Sciences 22, no. 24 (2021): 13595. http://dx.doi.org/10.3390/ijms222413595.

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The composition and organisation of the extracellular matrix (ECM), particularly the pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the presence of proteoglycans such as aggrecan, entrapped within a type II collagen fibrillar network, confers mechanical resilience underweight-bearing. Furthermore, components of the PCM including type VI collagen, perlecan, small leucine-rich proteoglycans—decorin and biglycan—and fibronectin facilitate the transduction of both biomechanical and biochemical signals to the residing chondrocytes, thereby regulati

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Sands, Ian, Jinhyung Lee, Wuxia Zhang, and Yupeng Chen. "RNA Delivery via DNA-Inspired Janus Base Nanotubes for Extracellular Matrix Penetration." MRS Advances 5, no. 16 (2020): 815–23. http://dx.doi.org/10.1557/adv.2020.47.

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AbstractRNA delivery into deep tissues with dense extracellular matrix (ECM) has been challenging. For example, cartilage is a major barrier for RNA and drug delivery due to its avascular structure, low cell density and strong negative surface charge. Cartilage ECM is comprised of collagens, proteoglycans, and various other noncollagneous proteins with a spacing of 20nm. Conventional nanoparticles are usually spherical with a diameter larger than 50-60nm (after cargo loading). Therefore, they presented limited success for RNA delivery into cartilage. Here, we developed Janus base nanotubes (JB

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Stocco, Elena, Silvia Barbon, Daniele Dalzoppo, et al. "Tailored PVA/ECM Scaffolds for Cartilage Regeneration." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/762189.

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Articular cartilage lesions are a particular challenge for regenerative medicine due to cartilage low self-ability repair in case of damage. Hence, a significant goal of musculoskeletal tissue engineering is the development of suitable structures in virtue of their matrix composition and biomechanical properties. The objective of our study was to designin vitroa supporting structure for autologous chondrocyte growth. We realized a biohybrid composite scaffold combining a novel and nonspecific extracellular matrix (ECM), which is decellularized Wharton’s jelly ECM, with the biomechanical proper

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Ashruf, Omer S., and Mohammad Yunus Ansari. "Natural Compounds: Potential Therapeutics for the Inhibition of Cartilage Matrix Degradation in Osteoarthritis." Life 13, no. 1 (2022): 102. http://dx.doi.org/10.3390/life13010102.

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Osteoarthritis (OA) is the most common degenerative joint disease characterized by enzymatic degradation of the cartilage extracellular matrix (ECM) causing joint pain and disability. There is no disease-modifying drug available for the treatment of OA. An ideal drug is expected to stop cartilage ECM degradation and restore the degenerated ECM. The ECM primarily contains type II collagen and aggrecan but also has minor quantities of other collagen fibers and proteoglycans. In OA joints, the components of the cartilage ECM are degraded by matrix-degrading proteases and hydrolases which are prod

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Kurkov, Alexandr, Anna Guller, Alexey Fayzullin, et al. "Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum." PLOS ONE 16, no. 1 (2021): e0245159. http://dx.doi.org/10.1371/journal.pone.0245159.

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Background It is unclear if amianthoid transformation (AT) of costal cartilage extracellular matrix (ECM) has an impact on the development of pectus excavatum (PE) and pectus carinatum (PC). Methods AT foci were examined in intrasurgical biopsy specimens of costal cartilages of children (8–17 years old) with PE (n = 12) and PC (n = 12) and in age-matching autopsy control samples (n = 10) using histological and immunohistochemical staining, atomic force and nonlinear optical microscopy, transmission and scanning electron microscopy, morphometry and statistics. Results AT areas were identified i

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Wang, Xiuyu, Yan Lu, Wan Wang, et al. "Effect of different aged cartilage ECM on chondrogenesis of BMSCs in vitro and in vivo." Regenerative Biomaterials 7, no. 6 (2020): 583–95. http://dx.doi.org/10.1093/rb/rbaa028.

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Abstract Extracellular matrix (ECM)-based biomaterials are promising candidates in cartilage tissue engineering by simulating the native microenvironment to regulate the chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) without exogenous growth factors. The biological properties of ECM scaffolds are primarily depended on the original source, which would directly influence the chondrogenic effects of the ECM materials. Despite the expanding investigations on ECM scaffolds in recent years, the selection of optimized ECM materials in cartilage regeneration was less report

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Badylak, Stephen, Leslie Geddes, Leslie Geddes, and Joe Obermiller. "Extracellular Matrix for Myocardial Repair." Heart Surgery Forum 6, no. 2 (2005): 20. http://dx.doi.org/10.1532/hsf.917.

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<P>Objective: To evaluate the remodeling characteristics of an extracellular matrix (ECM) scaffold when used as a template for myocardial repair. </P><P>Background: Xenogeneic ECM has been shown to be an effective scaffold for the repair and reconstitution of several tissues, including lower urinary tract structures, dura mater, the esophagus, musculotendinous tissues, and blood vessels. These ECM scaffolds are completely degraded in vivo and induce a host cellular response that supports constructive remodeling rather than scar tissue formation. </P><P>Methods: Fu

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Masaeli, Elahe, Fereshte Karamali, Shahriar Loghmani, Mohamadreza Baghaban Eslaminejad, and Mohammad Hossein Nasr-Esfahani. "Bio-engineered electrospun nanofibrous membranes using cartilage extracellular matrix particles." Journal of Materials Chemistry B 5, no. 4 (2017): 765–76. http://dx.doi.org/10.1039/c6tb02015a.

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Hernandez, Paula A., Miranda Moreno, Zahra Barati, et al. "Sexual Dimorphism in the Extracellular and Pericellular Matrix of Articular Cartilage." CARTILAGE 13, no. 3 (2022): 194760352211217. http://dx.doi.org/10.1177/19476035221121792.

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Objective Women have a higher prevalence and burden of joint injuries and pathologies involving articular cartilage than men. Although knee injuries affecting young women are on the rise, most studies related to sexual dimorphism target postmenopausal women. We hypothesize that sexual dimorphism in cartilage structure and mechanics is present before menopause, which can contribute to sex disparities in cartilage pathologies. Design Bovine knee was used as a model to study healthy adult cartilage. We compared elastic moduli under compression, abundances of extracellular and pericellular matrix

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ZHAO, Yan-hong, Qiang YANG, Qun XIA, et al. "In vitro cartilage production using an extracellular matrix-derived scaffold and bone marrow-derived mesenchymal stem cells." Chinese Medical Journal 126, no. 16 (2013): 3130–37. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20130212.

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Background Cartilage repair is a challenging research area because of the limited healing capacity of adult articular cartilage. We had previously developed a natural, human cartilage extracellular matrix (ECM)-derived scaffold for in vivo cartilage tissue engineering in nude mice. However, before these scaffolds can be used in clinical applications in vivo, the in vitro effects should be further explored. Methods We produced cartilage in vitro using a natural cartilage ECM-derived scaffold. The scaffolds were fabricated by combining a decellularization procedure with a freeze-drying technique

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Rojas-Murillo, Antonio, Jorge Lara-Arias, Héctor Leija-Gutiérrez, et al. "The Combination of Decellularized Cartilage and Amniotic Membrane Matrix Enhances the Production of Extracellular Matrix Elements in Human Chondrocytes." Coatings 14, no. 9 (2024): 1083. http://dx.doi.org/10.3390/coatings14091083.

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Articular cartilage lesions are challenging to regenerate, prompting the investigation of novel biomaterial-based therapeutic approaches. Extracellular matrix (ECM)-derived biomaterials are a promising option for this purpose; however, to date, the combination of amniotic membrane (AMM) and articular cartilage (ACM) has not been tested. This study evaluated different concentrations of soluble extracts from the decellularized ECM of amniotic membrane (dAMM) and articular cartilage (dACM), both individually and in combination, to determine their ability to maintain the chondrogenic phenotype in

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Raza, Iwan G. A., Sarah J. B. Snelling, and Jolet Y. Mimpen. "Defining the extracellular matrix in non-cartilage soft-tissues in osteoarthritis: a systematic review." Bone & Joint Research 13, no. 12 (2024): 703–15. https://doi.org/10.1302/2046-3758.1312.bjr-2024-0020.r1.

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AimsExtracellular matrix (ECM) is a critical determinant of tissue mechanobiology, yet remains poorly characterized in joint tissues beyond cartilage in osteoarthritis (OA). This review aimed to define the composition and architecture of non-cartilage soft joint tissue structural ECM in human OA, and to compare the changes observed in humans with those seen in animal models of the disease.MethodsA systematic search strategy, devised using relevant matrix, tissue, and disease nomenclature, was run through the MEDLINE, Embase, and Scopus databases. Demographic, clinical, and biological data were

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Zhang, Lu, Qianqian Feng, and Wei Kong. "ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis." Physiology 39, no. 5 (2024): 000. http://dx.doi.org/10.1152/physiol.00028.2023.

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Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.

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dos Santos, Ana Caroline, Livia Maria Barbosa de Andrade, Raí André Querino Candelária, et al. "From Cartilage to Matrix: Protocols for the Decellularization of Porcine Auricular Cartilage." Bioengineering 12, no. 1 (2025): 52. https://doi.org/10.3390/bioengineering12010052.

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The shortage of tissues and damaged organs led to the development of tissue engineering. Biological scaffolds, created from the extracellular matrix (ECM) of organs and tissues, have emerged as a promising solution for transplants. The ECM of decellularized auricular cartilage is a potential tool for producing ideal scaffolds for the recellularization and implantation of new tissue in damaged areas. In order to be classified as an ideal scaffold, it must be acellular, preserving its proteins and physical characteristics necessary for cell adhesion. This study aimed to develop a decellularizati

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Snider, Colten, David Grant, and Sheila A. Grant. "Investigation of an injectable gold nanoparticle extracellular matrix." Journal of Biomaterials Applications 36, no. 7 (2021): 1289–300. http://dx.doi.org/10.1177/08853282211051586.

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Post-traumatic osteoarthritis (PTOA) is a progressive articular degenerative disease that degrades articular cartilage and stimulates apoptosis in chondrocyte cells. An injectable decellularized, extracellular matrix (ECM) scaffold, that might be able to combat the effects of PTOA, was developed where the ECM was conjugated with 20 nm gold nanoparticles (AuNP) and supplemented with curcumin and hyaluronic acid (HA). Porcine diaphragm ECM was decellularized and homogenized; AuNPs were conjugated using chemical crosslinking followed by mixing with curcumin and/or HA. Injection force testing and

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Zhai, Chenjun, Xiao Zhang, Jun Chen, et al. "The effect of cartilage extracellular matrix particle size on the chondrogenic differentiation of bone marrow mesenchymal stem cells." Regenerative Medicine 14, no. 7 (2019): 663–80. http://dx.doi.org/10.2217/rme-2018-0082.

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Aim: To investigate the effect of cartilage extracellular matrix (ECM) particle size on the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Materials & methods: BMSCs were seeded into the scaffolds fabricated by small particle ECM materials and large particle ECM materials. For the positive control, chondrogenically induced BMSCs were seeded into commercial poly-lactic-glycolic acid scaffolds. Macroscopic observation, histological and immunohistochemical staining, mechanical testing and biochemical analysis were performed to the cell-scaffold constructs.

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Wang, Yu-Su, Wen-Hui Chu, Jing-Jie Zhai, et al. "High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells." World Journal of Stem Cells 16, no. 2 (2024): 176–90. http://dx.doi.org/10.4252/wjsc.v16.i2.176.

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BACKGROUND Cartilage defects are some of the most common causes of arthritis. Cartilage lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized extracellular matrix (ECM) derived from autologous, allogenic, or xenogeneic mesenchymal stromal cells (MSCs) can effectively restore osteochondral integrity. AIM To determine whether the decellularized ECM of antler reserve mesenchymal cells (RMCs), a xenogeneic material from antler stem cells, is superior to the currently available treatments for osteocho

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Strecanska, Magdalena, Lubos Danisovic, Stanislav Ziaran, and Michaela Cehakova. "The Role of Extracellular Matrix and Hydrogels in Mesenchymal Stem Cell Chondrogenesis and Cartilage Regeneration." Life 12, no. 12 (2022): 2066. http://dx.doi.org/10.3390/life12122066.

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Diseases associated with articular cartilage disintegration or loss are still therapeutically challenging. The traditional treatment approaches only alleviate the symptoms while potentially causing serious side effects. The limited self-renewal potential of articular cartilage provides opportunities for advanced therapies involving mesenchymal stem cells (MSCs) that are characterized by a remarkable regenerative capacity. The chondrogenic potential of MSCs is known to be regulated by the local environment, including soluble factors and the less discussed extracellular matrix (ECM) components.

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Mizuno, Shuichi, Eiichiro Takada, and Naomi Fukai. "Spheroidal Organoids Reproduce Characteristics of Longitudinal Depth Zones in Bovine Articular Cartilage." Cells Tissues Organs 202, no. 5-6 (2016): 382–92. http://dx.doi.org/10.1159/000447532.

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Articular cartilage has multiple histologically distinct longitudinal depth zones. Development and pathogenesis occur throughout these zones. Cartilage explants, monolayer cell culture and reconstituted 3-dimensional cell constructs have been used for investigating mechanisms of pathophysiology in articular cartilage. Such models have been insufficient to reproduce zone-dependent cellular characteristics and extracellular matrix (ECM) upon investigation into cartilage development and pathogenesis. Therefore, we defined a chondrocyte spheroid model consistently formed with isolated chondrocytes

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Maldonado, Maricela, and Jin Nam. "The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/284873.

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Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No therapy is currently available to completely prevent the initiation or progression of the disease partly due to poor understanding of the mechanisms of the disease pathology. Cartilage is the main tissue afflicted by OA, and chondrocytes, the sole cellular component in the tissue, actively participate in the degeneration process. Multiple factors affect the development and progression of OA including inflammation that

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Sun, Xuyang, Xiaoying Gu, Jingna Peng, et al. "PRDX2 Knockdown Inhibits Extracellular Matrix Synthesis of Chondrocytes by Inhibiting Wnt5a/YAP1/CTGF and Activating IL-6/JAK2/STAT3 Pathways in Deer Antler." International Journal of Molecular Sciences 23, no. 9 (2022): 5232. http://dx.doi.org/10.3390/ijms23095232.

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Although peroxiredoxin 2 (PRDX2) plays a vital role in relieving oxidative stress, its physiological function in cartilage development remains almost unknown. In this study, we found that the expression of PRDX2 significantly increased in the chondrocytes compared with pre-chondrocytes. PRDX2 knockdown significantly decreased the expression of extracellular matrix (ECM) protein (Col2a and Aggrecan), which led to blocked cartilage formation. Moreover, PRDX2 knockdown also inhibited the expression of connective tissue growth factor (CTGF). CTGF is an important growth factor that regulates synthe

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Chen, Mei-Feng, Chih-Chien Hu, Yung-Heng Hsu, et al. "The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis development." Bone & Joint Research 12, no. 12 (2023): 734–46. http://dx.doi.org/10.1302/2046-3758.1212.bjr-2023-0087.r1.

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AimsTherapeutic agents that prevent chondrocyte loss, extracellular matrix (ECM) degradation, and osteoarthritis (OA) progression are required. The expression level of epidermal growth factor (EGF)-like repeats and discoidin I-like domains-containing protein 3 (EDIL3) in damaged human cartilage is significantly higher than in undamaged cartilage. However, the effect of EDIL3 on cartilage is still unknown.MethodsWe used human cartilage plugs (ex vivo) and mice with spontaneous OA (in vivo) to explore whether EDIL3 has a chondroprotective effect by altering OA-related indicators.ResultsEDIL3 pro

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Ababneh, Khansa Taha, and Taiseer Hussain Al-Khateeb. "Immunolocalization of Proteoglycans in Meckel’s Cartilage of the Rat." Open Dentistry Journal 3, no. 1 (2009): 177–83. http://dx.doi.org/10.2174/1874210600903010177.

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The aim of this study was to investigate the presence and distribution of proteoglycans within Meckel’s cartilage of rat embryos. A standard indirect immunoperoxidase technique was used on paraffin sections of rat heads. Sections were incubated with monoclonal antibodies recognising core protein epitopes in the proteoglycans versican and CD44. Polyclonal antibodies localized the proteoglycans decorin, biglycan and lumican. Versican was expressed by chondrocytes, but very weekly by the extracellular matrix. Decorin was strongly expressed by both of chondrocytes and the ECM. Both of biglycan and

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Maly, Kathrin, Enrique Andres Sastre, Eric Farrell, Andrea Meurer, and Frank Zaucke. "COMP and TSP-4: Functional Roles in Articular Cartilage and Relevance in Osteoarthritis." International Journal of Molecular Sciences 22, no. 5 (2021): 2242. http://dx.doi.org/10.3390/ijms22052242.

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Osteoarthritis (OA) is a slow-progressing joint disease, leading to the degradation and remodeling of the cartilage extracellular matrix (ECM). The usually quiescent chondrocytes become reactivated and accumulate in cell clusters, become hypertrophic, and intensively produce not only degrading enzymes, but also ECM proteins, like the cartilage oligomeric matrix protein (COMP) and thrombospondin-4 (TSP-4). To date, the functional roles of these newly synthesized proteins in articular cartilage are still elusive. Therefore, we analyzed the involvement of both proteins in OA specific processes in

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Liu, Jie, and Xiaomu Tang. "Characterizing the microstructural organization of collagenous fibrils in articular cartilage extracellular matrix using diffusion tensor imaging: A cross-sectional observational study." Medicine 104, no. 25 (2025): e42902. https://doi.org/10.1097/md.0000000000042902.

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In the exploration of articular cartilage extracellular matrix (ECM) microstructural organization, the use of diffusion tensor imaging (DTI) has emerged as a promising noninvasive imaging technique. The study aimed to characterize the collagenous fibril architecture within the ECM of articular cartilage and to correlate these microstructural parameters with clinical symptoms in patients with varying degrees of knee pain. A cross-sectional study was conducted on a cohort of 472 patients who presented with knee pain. DTI metrics, including mean diffusivity (MD), fractional anisotropy (FA), axial

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Wang, Tianyi, Janice H. Lai, Li-Hsin Han, Xinming Tong, and Fan Yang. "Modulating stem cell–chondrocyte interactions for cartilage repair using combinatorial extracellular matrix-containing hydrogels." Journal of Materials Chemistry B 4, no. 47 (2016): 7641–50. http://dx.doi.org/10.1039/c6tb01583b.

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Puiggalí-Jou, Anna, Isabel Hui, Lucrezia Baldi, et al. "Biofabrication of anisotropic articular cartilage based on decellularized extracellular matrix." Biofabrication 17, no. 1 (2025): 015044. https://doi.org/10.1088/1758-5090/ad9cc2.

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Abstract Tissue-engineered grafts that mimic articular cartilage show promise for treating cartilage injuries. However, engineering cartilage cell-based therapies to match zonal architecture and biochemical composition remains challenging. Decellularized articular cartilage extracellular matrix (dECM) has gained attention for its chondro-inductive properties, yet dECM-based bioinks have limitations in mechanical stability and printability. This study proposes a rapid light-based bioprinting method using a tyrosine-based crosslinking mechanism, which does not require chemical modifications of d

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Kato, Y., and D. Gospodarowicz. "Effect of exogenous extracellular matrices on proteoglycan synthesis by cultured rabbit costal chondrocytes." Journal of Cell Biology 100, no. 2 (1985): 486–95. http://dx.doi.org/10.1083/jcb.100.2.486.

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We examined the effect of an extracellular matrix (ECM), produced by either bovine corneal endothelial (BCE) cells or mouse PF HR-9 teratocarcinoma cells, on the ability of rabbit costal chondrocytes to re-express their phenotype once confluent. Rabbit chondrocytes seeded at low densities and grown on plastic tissue culture dishes produced a heterogeneous cell population composed of both overtly differentiated and poorly differentiated chondrocytes, as well as fibroblastic cells. On the other hand, cultures grown on BCE-ECM- or HR-9-ECM-coated dishes reorganized into a homogeneous cartilage-li

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Hayes, Anthony J., John Whitelock, and James Melrose. "Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis." International Journal of Molecular Sciences 23, no. 4 (2022): 1934. http://dx.doi.org/10.3390/ijms23041934.

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The aim of this study was to highlight the roles of perlecan in the regulation of the development of the rudiment developmental cartilages and growth plate cartilages, and also to show how perlecan maintains permanent articular cartilage homeostasis. Cartilage rudiments are transient developmental templates containing chondroprogenitor cells that undergo proliferation, matrix deposition, and hypertrophic differentiation. Growth plate cartilage also undergoes similar changes leading to endochondral bone formation, whereas permanent cartilage is maintained as an articular structure and does not

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Davies, Sherri R., Shinji Sakano, Yong Zhu, and Linda J. Sandell. "Distribution of the Transcription Factors Sox9, AP-2, and [Delta]EF1 in Adult Murine Articular and Meniscal Cartilage and Growth Plate." Journal of Histochemistry & Cytochemistry 50, no. 8 (2002): 1059–65. http://dx.doi.org/10.1177/002215540205000808.

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The control of extracellular matrix (ECM) production is important for the development, maintenance, and repair of cartilage tissues. Matrix molecule synthesis is generally regulated by the rate of gene transcription determined by DNA transcription factors. We have shown that transcription factors Sox9, AP-2, and [delta]EF1 are able to alter the rate of CD-RAP transcription in vitro: Sox9 upregulates, AP-2 exhibits biphasic effects, and [delta]EF1 represses expression of the CD-RAP gene. To correlate these in vitro activities in vivo, transcription factors were co-immunolocalized with ECM prote

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Mählich, Daniela, Anne Glasmacher, Ilka Müller, et al. "Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee." International Journal of Molecular Sciences 22, no. 6 (2021): 3073. http://dx.doi.org/10.3390/ijms22063073.

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Osteoarthritis (OA) is a multifactorial disease which is characterized by a change in the homeostasis of the extracellular matrix (ECM). The ECM is essential for the function of the articular cartilage and plays an important role in cartilage mechanotransduction. To provide a better understanding of the interaction between the ECM and the actin cytoskeleton, we investigated the localization and expression of the Ca2+-dependent proteins cartilage oligomeric matrix protein (COMP), thrombospondin-1 (TSP-1), plastin 3 (PLS3) and stromal interaction molecule 1 (STIM1). We investigated 16 patients w

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Griffin, MF, M. Szarko, A. Seifailan, and PE Butler. "Nanoscale Surface Modifications of Medical Implants for Cartilage Tissue Repair and Regeneration." Open Orthopaedics Journal 10, no. 1 (2016): 824–35. http://dx.doi.org/10.2174/1874325001610010824.

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Background: Natural cartilage regeneration is limited after trauma or degenerative processes. Due to the clinical challenge of reconstruction of articular cartilage, research into developing biomaterials to support cartilage regeneration have evolved. The structural architecture of composition of the cartilage extracellular matrix (ECM) is vital in guiding cell adhesion, migration and formation of cartilage. Current technologies have tried to mimic the cell’s nanoscale microenvironment to improve implants to improve cartilage tissue repair. Methods: This review evaluates nanoscale techniques u

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Radeloff, Katrin, Dorothee Weiss, Rudolf Hagen, Norbert Kleinsasser, and Andreas Radeloff. "Differentiation Behaviour of Adipose-Derived Stromal Cells (ASCs) Seeded on Polyurethane-Fibrin Scaffolds In Vitro and In Vivo." Biomedicines 9, no. 8 (2021): 982. http://dx.doi.org/10.3390/biomedicines9080982.

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Adipose-derived stromal cells (ASCs) are a promising cell source for tissue engineering and regenerative medicine approaches for cartilage replacement. For chondrogenic differentiation, human (h)ASCs were seeded on three-dimensional polyurethane (PU) fibrin composites and induced with a chondrogenic differentiation medium containing TGF-ß3, BMP-6, and IGF-1 in various combinations. In addition, in vitro predifferentiated cell-seeded constructs were implanted into auricular cartilage defects of New Zealand White Rabbits for 4 and 12 weeks. Histological, immunohistochemical, and RT-PCR analyses

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Zhu, Shouan, Pengfei Chen, Yang Chen, Muzhi Li, Can Chen, and Hongbin Lu. "3D-Printed Extracellular Matrix/Polyethylene Glycol Diacrylate Hydrogel Incorporating the Anti-inflammatory Phytomolecule Honokiol for Regeneration of Osteochondral Defects." American Journal of Sports Medicine 48, no. 11 (2020): 2808–18. http://dx.doi.org/10.1177/0363546520941842.

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Background: Osteoarthritis is the leading cause of disability worldwide; cartilage degeneration and defects are the central features. Significant progress in tissue engineering holds promise to regenerate damaged cartilage tissue. However, a formidable challenge is to develop a 3-dimensional (3D) tissue construct that can regulate local immune environment to facilitate the intrinsic osteochondral regeneration. Purpose: To evaluate efficacy of a 3D-printed decellularized cartilage extracellular matrix (ECM) and polyethylene glycol diacrylate (PEGDA) integrated novel scaffold (PEGDA/ECM) togethe

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Dharmayuda, Cokorda Gede Oka, Anak Agung Ngurah Subawa, Ketut Siki Kawiyana, and Febyan. "The Role of Proteinases in Osteoarthritis: A Brief Review of New Potent Cartilage Metabolism Therapeutic Target." Hong Kong Journal of Orthopaedic Research 4, no. 2 (2021): 35–38. http://dx.doi.org/10.37515/ortho.8231.4204.

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Osteoarthritis (OA) is the most frequent form of degenerative joint disease that becomes a major source of disability worldwide. The loss of articular cartilage is the central etiology of osteoarthritis. Cartilage is solely composed of one cell type, the chondrocytes, which are surrounded by a large volume of extracellular matrix (ECM). Extracellular matrix components consist of two main macromolecules, namely collagen and aggrecan. The degradation of these molecules plays a significant role in OA pathological process, although degradation of less abundant molecules composing the matrix organi

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Cui, Jiarui, and Jiaming Zhang. "Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities." International Journal of Molecular Sciences 23, no. 16 (2022): 9253. http://dx.doi.org/10.3390/ijms23169253.

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Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic reticulum stress and chondrocyte apoptosis, resulting in rare skeleton diseases. The bouquet-like structure of COMP allows it to act as a bridging molecule that regulates cellular phenotype and function. COMP is able to interact with many other ECM components and binds directly to a variety of cellular receptors and growth factors. The roles of COMP in other skeleton diseases, such as osteoarthritis, have been imp

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Xiao, Tongguang, Weimin Guo, Mingxue Chen, et al. "Fabrication and In Vitro Study of Tissue-Engineered Cartilage Scaffold Derived from Wharton’s Jelly Extracellular Matrix." BioMed Research International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/5839071.

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The scaffold is a key element in cartilage tissue engineering. The components of Wharton’s jelly are similar to those of articular cartilage and it also contains some chondrogenic growth factors, such as insulin-like growth factor I and transforming growth factor-β. We fabricated a tissue-engineered cartilage scaffold derived from Wharton’s jelly extracellular matrix (WJECM) and compared it with a scaffold derived from articular cartilage ECM (ACECM) using freeze-drying. The results demonstrated that both WJECM and ACECM scaffolds possessed favorable pore sizes and porosities; moreover, they s

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Uzieliene, Ilona, Paulina Bialaglovyte, Rokas Miksiunas, et al. "Menstrual Blood-Derived Stem Cell Paracrine Factors Possess Stimulatory Effects on Chondrogenesis In Vitro and Diminish the Degradation of Articular Cartilage during Osteoarthritis." Bioengineering 10, no. 9 (2023): 1001. http://dx.doi.org/10.3390/bioengineering10091001.

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Articular cartilage is an avascular tissue with a limited capacity for self-regeneration, leading the tissue to osteoarthritis (OA). Mesenchymal stem cells (MSCs) are promising for cartilage tissue engineering, as they are capable of differentiating into chondrocyte-like cells and secreting a number of active molecules that are important for cartilage extracellular matrix (ECM) synthesis. The aim of this study was to evaluate the potential of easily accessible menstrual blood-derived MSC (MenSC) paracrine factors in stimulating bone marrow MSC (BMMSCs) chondrogenic differentiation and to inves

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Dong, Rui, Jun Ying, Taotao Xu та ін. "Bushenhuoxue Formula Facilitates Articular Cartilage Repair and Attenuates Matrix Degradation by Activation of TGF-β Signaling Pathway". Evidence-Based Complementary and Alternative Medicine 2018 (8 жовтня 2018): 1–11. http://dx.doi.org/10.1155/2018/2734581.

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Objective. To investigate the effect and underlying mechanism of Bushenhuoxue (BSHX) formula on articular cartilage repair. Methods. Twenty-four full-thickness cartilage defect rats were divided into two groups: model group and BSHX group (treated with BSHX formula). Macroscopic observation and histopathological study were conducted after 4- and 8-week treatment. Additionally, we also evaluated chondrocyte proliferation, extracellular matrix (ECM) deposition, cartilage degradation, and chondrocyte hypertrophy-related genes expression in chondrogenic ATDC5 cells cultured in BSHX formula-mediate

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Jones, Calvin L., Brian T. Penney, and Sophia K. Theodossiou. "Engineering Cell–ECM–Material Interactions for Musculoskeletal Regeneration." Bioengineering 10, no. 4 (2023): 453. http://dx.doi.org/10.3390/bioengineering10040453.

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The extracellular microenvironment regulates many of the mechanical and biochemical cues that direct musculoskeletal development and are involved in musculoskeletal disease. The extracellular matrix (ECM) is a main component of this microenvironment. Tissue engineered approaches towards regenerating muscle, cartilage, tendon, and bone target the ECM because it supplies critical signals for regenerating musculoskeletal tissues. Engineered ECM–material scaffolds that mimic key mechanical and biochemical components of the ECM are of particular interest in musculoskeletal tissue engineering. Such

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Michelacci, Yara M., Raquel Y. A. Baccarin, and Nubia N. P. Rodrigues. "Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions." Life 13, no. 7 (2023): 1460. http://dx.doi.org/10.3390/life13071460.

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Chondrocytes are the main cell type in articular cartilage. They are embedded in an avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are responsible for the synthesis and turnover of the ECM, in which the major macromolecular components are collagen, proteoglycans, and non-collagen proteins. The crosstalk between chondrocytes and the ECM plays several relevant roles in the regulation of cell phenotype. Chondrocytes live in an avascular environment in healthy cartilage with a low oxygen supply. Although chondrocytes are adapted to anaerobic conditions, many of their

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Cheng, Jiyun, Genxiang Rong, Ziqi Wang, et al. "ECM-Mimicking Hydrogels Loaded with Bone Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Cartilage Defects." Evidence-Based Complementary and Alternative Medicine 2022 (November 3, 2022): 1–13. http://dx.doi.org/10.1155/2022/3450672.

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It is well-established that treating articular cartilage injuries is clinically challenging since they lack blood arteries, nerves, and lymphoid tissue. Recent studies have revealed that bone marrow stem cell-derived exosomes (BMSCs-Exos) exert significant chondroprotective effects through paracrine secretions, and hydrogel-based materials can synergize the exosomes through sustained release. Therefore, this research aims to synthesize an ECM (extracellular matrix)-mimicking gelatin methacryloyl (GelMA) hydrogel modified by gelatin combined with BMSCs-derived exosomes to repair cartilage damag

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