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Journal articles on the topic "Carty, Dave"
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McIntosh, Gregory. "Conventional Wisdom and the Date of the Kunstmann I Chart." Cartographica: The International Journal for Geographic Information and Geovisualization 55, no. 2 (May 2020): 85–98. http://dx.doi.org/10.3138/cart-2019-0005.
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Robert, Richard C. "Establishment and Maintenance of an Up-to-Date Emergency Cart." Journal of Oral and Maxillofacial Surgery 66, no. 8 (August 2008): 1–2. http://dx.doi.org/10.1016/j.joms.2008.05.006.
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Débarbat, Suzanne. "Up to Date Proper Motions of Stars from Old “Carte Du Ciel” Plates." Highlights of Astronomy 10 (1995): 141–42. http://dx.doi.org/10.1017/s1539299600010704.
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Bezerra, Evandro D., Jordan Gauthier, Alexandre V. Hirayama, Barbara S. Pender, Reed M. Hawkins, Aesha Vakil, Rachel N. Steinmetz, et al. "Factors Associated with Response, CAR-T Cell In Vivo Expansion, and Progression-Free Survival after Repeat Infusions of CD19 CAR-T Cells." Blood 134, Supplement_1 (November 13, 2019): 201. http://dx.doi.org/10.1182/blood-2019-123807.
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Background CD19-targeted chimeric antigen receptor-engineered (CD19 CAR)-T cell immunotherapy has shown promising efficacy in patients with relapsed or refractory (R/R) B-cell malignancies. The potential benefits of repeat infusions of CD19 CAR-T cells are unknown, and the factors associated with response, CAR-T cell in vivo expansion, and progression-free survival (PFS) after repeat infusion of CD19 CAR-T cells have not been investigated. Methods We analyzed the outcomes of patients with R/R B-cell malignancies after a second infusion of CD19 CAR-T cells (CART2) on a phase 1/2 trial (NCT01865617) at our institution. Responses after CAR-T cell therapy were evaluated around day 28 after infusion and defined according to the 2018 NCCN guidelines for acute lymphoblastic leukemia (ALL), 2018 iwCLL for chronic lymphocytic leukemia (CLL), and the Lugano criteria for non-Hodgkin lymphoma (NHL). Logistic, Cox and linear regression were used for multivariable analyses of response, progression-free survival and peak CD8+ CAR-T in blood, respectively. Bayesian model averaging was performed for variable selection. Results Forty-four patients evaluable for response (ALL, n=14; CLL, n=11; NHL, n=19) were included in this study. The median age at the time of CART2 was 58 (range, 23-73). Patients were heavily pre-treated (median prior therapies, 6; range, 2-13), and 16 patients (36%) had bulky (≥ 5cm) nodal or extramedullary disease. The median time from the first CAR-T infusion (CART1) to CART2 was 70 days (range, 28-712). Twenty-eight patients (64%) had received a CART1 dose ≥ 2x106 CAR-T cells/kg. Fifteen patients (32%) had not responded to CART1, 22 (50%) relapsed or progressed after having initially responded (complete response [CR], n=15; partial response [PR], n=7) to CART1; 7 (16%) received CART2 in PR after CART1. All characteristics are shown in the Table. We observed responses in all disease types, including 3 of 14 ALL patients (21%; all CR/CRi), 4 of 11 CLL patients (36%; CR/CRi, n=3; partial response [PR], n=1), and 9 of 19 NHL patients (47%; CR, n=2; PR, n=7). After a median follow-up of 43 months (range, 16-66) in alive and responding patients, the estimated 4-year PFS probability in responders was 23% (95% CI, 9-59%). The 4-year overall survival probability in responders was 36% (95% CI 19-71%) compared to 24% (95% CI, 12-47) in non-responders. Multivariable logistic regression modeling identified predictors of response after CART2: CART1 lymphodepletion (high-intensity cyclophosphamide and fludarabine [CyFlu] vs no CyFlu, OR=12.19, 95% CI, 1.10-1689.85, p=0.04), and peak of in vivo CAR-T cell expansion after CART2 (OR=2.31 per log10 CD8+ CAR-T cell/µL increase, 95% CI, 1.17-5.29, p=0.01). In a multivariable Cox model, a higher peak of CD8+ CAR-T cells after CART2 (HR=0.47 per log10 CD8+ CAR-T cell/µL increase, 95%CI, 0.33-0.68, p<0.001); CART2 > CART1 cell dose was associated with longer PFS (HR=0.36, 95% CI, 0.16-0.86, p=0.02). This suggested that CD8+ CAR-T cell peak after CART2 and factors increasing CART2 peak (e.g. prevention of immune rejection or increase in the infused cell dose) are key elements associated with outcomes of CART2. Hence, we looked at factors associated with higher CD8+ CART2 peak. In multivariable linear regression, CART1 CyFlu predicted a higher peak of CD8+ CAR-T cells after CART2 (high-intensity CyFlu vs no CyFlu, p<0.001 ; low-intensity CyFlu versus no CyFlu, p=0.002) after adjusting for disease type (CLL vs ALL, p=0.02; NHL vs ALL, p=0.04) and the total CD19+ cell count in blood (p=0.02). CyFlu being the most commonly used lymphodepletion prior to CAR-T cell therapy, we evaluated the impact of CART1 CyFlu lymphodepletion intensity by comparing high-intensity to low-intensity CyFlu in our multivariable models. Logistic regression suggested higher probabilities of response to CART2 in patients who received high-intensity compared to low-intensity CyFlu prior to CART1 (OR=3.83, 95%CI, 0.85-21.83, p=0.08). In multivariable analysis, CART1 high-intensity CyFlu was associated with higher CD8+ CAR-T cell numbers at day 60 after CART2 compared to low-intensity CyFlu (p=0.01) after adjusting for disease type and total CD19+ cell count in the blood. Conclusion Our findings suggest outcomes after second infusions of CD19 CAR-T cells might be improved with high-intensity CyFlu lymphodepletion prior to CART1 and by increasing the CAR-T cell dose at the time of CART2. Table Disclosures Hirayama: DAVA Oncology: Honoraria. Till:Mustang Bio: Patents & Royalties, Research Funding. Kiem:Rocket Pharma: Consultancy, Equity Ownership; Homology Medicines: Consultancy, Equity Ownership; CSL Behring: Consultancy; Magenta Therapeutics: Consultancy. Shadman:Mustang Biopharma: Research Funding; Gilead: Research Funding; Bigene: Research Funding; AstraZeneca: Consultancy; Merck: Research Funding; Atara: Consultancy; AbbVIe: Consultancy, Research Funding; Genentech, Inc.: Consultancy, Research Funding; TG Therapeutics: Research Funding; Sound Biologics: Consultancy; Pharmacyclics: Consultancy, Research Funding; ADC Therapeutics: Consultancy; Verastem: Consultancy; Celgene: Research Funding; Acerta: Research Funding; Emergent: Research Funding; Sunesis: Research Funding. Cassaday:Amgen: Consultancy, Research Funding; Pfizer: Consultancy, Honoraria, Research Funding; Incyte: Research Funding; Kite/Gilead: Research Funding; Merck: Research Funding; Seattle Genetics: Research Funding; Seattle Genetics: Other: Spouse's disclosure: employment, stock and other ownership interests. Riddell:Juno Therapeutics: Equity Ownership, Patents & Royalties, Research Funding; Adaptive Biotechnologies: Consultancy; Lyell Immunopharma: Equity Ownership, Patents & Royalties, Research Funding. Maloney:BioLine RX, Gilead,Genentech,Novartis: Honoraria; Juno Therapeutics: Honoraria, Patents & Royalties: patients pending , Research Funding; Celgene,Kite Pharma: Honoraria, Research Funding; A2 Biotherapeutics: Honoraria, Other: Stock options . Turtle:Precision Biosciences: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Eureka Therapeutics: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Juno Therapeutics: Patents & Royalties: Co-inventor with staff from Juno Therapeutics; pending, Research Funding; Caribou Biosciences: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Kite/Gilead: Other: Ad hoc advisory board member; Allogene: Other: Ad hoc advisory board member; Nektar Therapeutics: Other: Ad hoc advisory board member, Research Funding; T-CURX: Membership on an entity's Board of Directors or advisory committees; Novartis: Other: Ad hoc advisory board member; Humanigen: Other: Ad hoc advisory board member.
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Sandelowski, Margarete. "Response to Dave Holmes and Cary Federman: Killing for the state: the darkest side of American nursing." Nursing Inquiry 10, no. 2 (June 2003): 139. http://dx.doi.org/10.1046/j.1440-1800.2003.00172.x.
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Beal, Brian. "Making older workers happy to carry on." Development and Learning in Organizations: An International Journal 30, no. 2 (March 7, 2016): 22–24. http://dx.doi.org/10.1108/dlo-12-2015-0098.
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Purpose The paper aims to examine the influences of the competencies, social skills and continuous learning ability on career success and career satisfaction among workers aged 50 and over. Design/methodology/approach A mixed methods approach consisted of 920 surveys and 11 semi-structured interviews with working individuals aged 50 or above, registered at a job agency specialized in older employees in The Netherlands. Multiple regression and content analysis were used to analyze the findings. Findings The survey showed a positive relationship between the competencies and career success and career satisfaction. However, the interviews revealed that not all older workers perceived the need to continuously stay up-to-date as positive, pushing them into retirement. Originality/value The influence of competencies on career success and career satisfaction of older workers has received only little attention from researchers.
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Tu, Sanfang, Rui Huang, Xuan Zhou, Yanjie He, Zhao Liang, Lei Wang, Lung-Ji Chang, and Yuhua Li. "Combination of CD19 and CD70 Specific Chimeric Antigen Receptor T Cells Achieves Long-Term Disease-Free Survival in Relapsed and Refractory Primary Central Nervous System Diffuse Large B Cell Lymphoma." Blood 132, Supplement 1 (November 29, 2018): 5389. http://dx.doi.org/10.1182/blood-2018-99-117694.
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Abstract Background: Chimeric antigen receptor-modified T cells (CARTs) targeting CD19 has illustrated therapeutic efficacy in diffuse large B cell lymphoma (DLBCL). However, severe cytokine release syndrome (sCRS) reaction and CAR-T-cell-related encephalopathy syndrome (CRES) are the main adverse reactions of CART therapy. Because of the concern of severe CRES which is associated with potential mortality, patients with primary central nervous system Lymphoma(PCNSL) are excluded in most of CART clinical trials. CD70 is a promising therapeutic target due to the restricted expression pattern in normal tissues and overexpression in some lymphoma tissues, so CD70 specific CARTs maybe avoid CD19-negative relapse .Here we report a case with refractory and relapsed PCNSL who achieved long-term disease-free survival by combination therapy of CD19 and CD70 specific CARTs without inducing CRS or CRES. Methods: CD3+ cells were selected from the apheresis PBMC and activated before lentiviral 4SCAR infection. The cells were transduced with a caspase 9-inducible, safety-engineered lentivector CAR containing anti-CD19 or -CD70 scFv fused with multiple intracellular signaling domains: CD28/CD27/CD3z-iCasp9 (4SCAR19 or 4SCAR70). The quality of apheresis cells, gene transfer and T cell proliferation efficiencies, and effective CAR T infusion dose were quantitatively scored and documented. Tumor sections were immunohistochemically stained with different antibodies including anti-CD19 and anti-CD70 antibodies to confirm antigen expression. The patient received cyclophosphamide and fludarabine conditioning regimen before the dual CARTs cell infusions. Case presentation: A 67-year-old male who was diagnosed as PCNSL of DLBCL in 2011.The patient received 6 cycles of temozolomide and high does methotrexate, and achieved CR. In December 2016 he relapsed and was treated with right frontal lobe space-occupying resection and multi-course chemotherapy including 2 course of rituximab, high dose methotrexate and temozolomide ,and 6 courses of rituximab, high dose methotrexate and ibrutinib,and he achieved remission again.However, He relapsed again in August 2017, with the clinical symptoms of dizziness , fatigue, left corners of the mouth askew and occlusal difficulties.MRI presented a residual mass on the right side of the postoperative cavity of 26mm*35mm*30mm and stale hemorrhage in left basal ganglia. After confirmation for CD19 and CD70 expression in his tumor specimens, the pt enrolled in the clinicaltrail :"Combination CART cell therapy targeting hematological malignancies"(clinicaltrail.gov registry NCT03125577).He received 4SCAR19 and 4SCAR70 T cells targeting CD19 and CD70 following lymphodepletion chemotherapy with FC regimen conditioning (FLU 30mg/m2, d1-3; CTX 300mg/m2, d1-3) in October 2017. Brain MRI 1 month later showed complete remission and the pt had symptomatic improvement. To date, after more than 8 months of follow-up, the pt remains in CR (figure1) and CART cells still can be detected . There was no CRS or CRES during the treatment and in follow-up period. Conclusions: The study results demonstrate that CARTs are able to pass through the blood-brain barrier without inducing CRS or CRES, suggesting that CNS tumor is not an absolute contraindication to 4sCART therapy. In addition, the combination of CD19 and CD70 specific 4sCARTs could effectively target PCNSL and achieves long-term disease-free survival without sCRS or CRES. Disclosures No relevant conflicts of interest to declare.
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Tu, Sanfang, Rui Huang, Lan Deng, Xuan Zhou, Yanjie He, Weijun Zhou, Jilong Yang, et al. "Therapy of 4s Chimeric Antigen Receptor T Cells Achieves Long-Term Disease-Free Survival with No Severe CRS or Cres in Patients with Relapsed and Refractory Acute Lymphoblastic Leukemia." Blood 132, Supplement 1 (November 29, 2018): 2696. http://dx.doi.org/10.1182/blood-2018-99-118928.
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Abstract Background: CD19 targeting chimeric antigen receptor T cells(CART19) therapy have shown great therapeutic potential in relapsed and refractory B cell acute lymphoblastic leukemia (ALL), but associated with risk of life-threatening adverse effects as severe cytokine release syndrome (sCRS) and CAR-T-cell-related encephalopathy syndrome (CRES).It's been reported that high leukemia burden before CART therapy, and high does infused CART cells are associated with severity of CRS and CRES. To decrease the risk of severe adverse effect, we applied integrated therapeutic strategy of using fourth generation CART cells , reducing leukemia blasts burden in bone marrow, and decreasing the dose of infused CART cells (www.clinicaltrials.gov; #NCT03407859 and #NCT03125577 ). Methods: Between May 23, 2016 and July 2, 2018,the trial enrolled 20 patients (pts) who were exhausted with all available treatment options, life expectancy >2 months,CD19-positive and diagnosis of B lineage ALL.T cells were apheresis collected and transduced with an apoptosis-inducible, safety-engineered lentivector CAR with the following intracellular signaling domains: CD28/CD27/CD3ζ-iCasp9 (4SCAR). In vitro amplication of CART was not performed. In pts with bone marrow blasts exceeding 50.0%, VDCP or similar chemotherapy was given to reduce the tumor burden, and then received FC conditioning regimen (FLU 30mg/m2, d1-3; CTX 300mg/m2, d1-3), while FC regimen was directly carried out in pts with bone marrow blasts less than 50.0%.In this trial, Pts received single CD19-targeted CARTs or multi-CARTs targeting CD19 and an additional antigen of CD22 or CD123.The level of CAR-T cells and cytokines in peripheral blood, as well as tumor burden was measured after infusion. Results: 20 pts were enrolled and infused with CAR-T cells. The median age is 37.5 (16-67) years old. Of these pts, 5 had prior HSCT and 14 had adverse genetic abnormalities, including 4 pts (20%) who were Philadelphia chromosome-positive(Ph+). All pts were previously treated with 2-22 courses of cytotoxic chemotherapy regimens. The overall objective response rate was 85%(17/20), and the complete response(CR) rate was 80%(16/20). The complete remission rate of 12 pts receiving single CD19-targeted CART therapy was 83 %(10/12), while 33%(4/12) of them had disease relapse at 6 months after infusion. Of the 7 people who received multi-CARTs infusion, 71%(5/7) achieved complete remission, with relapse rate of 29%(2/7) at 6 months after infusion. 3 pts who relapsed post transplantation received combination therapy of anti-CD19 CART and anti-CD123 CART, and all achieved minimal residual disease-negative CR within 1 month after CART infusion, 2 of whom maintained disease-free survival for 7 months and 11 months to date, respectively. Among the 7 people who underwent HSCT after achieving CR, 6 of them maintained disease-free survival for 3 months to 9 months. At a median follow-up of 115.5 days (ranging from14 to 384), the median overall survival was 269 days and the median event-free survival was 232 days. During treatment and follow-up, the most common adverse events were grade 1-2 cytokine release syndrome (CRS), with an incidence of 55%.No grade 3 or higher CRS was observed.12 pts were infused with a dose equal to or exceeding 5*10^5/kg, 10 of whom had CRS response. While only 2 of the 8 pts who received the infusion dose of less than 5*10^5/kg had CRS reaction and both of them were grade 1 CRS, suggesting low CAR-T cell doses decrease the risk of CRS (P=0.009). Interestingly, the objective response rate did not differ significantly between the low dose and high dose group. Conclusions: Based on fourth generation CART system, a therapeutic strategy of low tumor burden and low CART infusion dose shows a safer profiling while remaining potent efficacy against leukemia. Disclosures No relevant conflicts of interest to declare.
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Chen, Han Li, and Tao Qin. "Study on the Date Generation Process of Chinese Thermal Power." Applied Mechanics and Materials 128-129 (October 2011): 1234–37. http://dx.doi.org/10.4028/www.scientific.net/amm.128-129.1234.
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In China, the thermal power is the main structure of power source. We consider that analysis thermal power’s date generation process is very important to precise planning of thermal power and whole electricity market. For testing the impact of inspection and external factors on thermal power, we study date generation process of thermal power by structural change model that carry unit root test and trend stationary test. This conclusion indicates that thermal power’s date generation process is the unit root process of structure change and isn’t trending stationary process.
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McShane, Joseph M. "People, Priests, and Prelates: Ecclesiastical Democracy and the Tensions of Trusteeism. By Patrick W. Carey. Notre Dame: University of Notre Dame Press, 1987. xii + 362 pp. $26.95." Church History 57, no. 3 (September 1988): 386–88. http://dx.doi.org/10.2307/3166607.
Full textDissertations / Theses on the topic "Carty, Dave"
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LAGRANGE, DOMINIQUE. "Estimation de la date et de l'amplitude d'une rupture conditionnellement a sa detection par une carte cusum." Paris, Institut national d'agronomie de Paris Grignon, 1997. http://www.theses.fr/1997INAP0045.
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Les cartes de controle sont des outils d'amelioration de la qualite des produits. Lorsque la carte de controle signale que le processus est hors-controle, cela signifie que le processus de production est deregle, cependant elle n'indique ni l'importance du dereglage ni quand il a commence. L'estimation de la date et de l'amplitude de la rupture revet donc un grand interet pratique : elle permet de savoir a partir de quand et de combien la production s'est deterioree et ainsi de prendre des decisions adequates. Le responsable de la qualite peut decider quelle partie de la production est suspecte, c'est a dire quelle partie a ete realisee dans des conditions de processus non standard. Au vu des proprietes d'optimalite asymptotique, nous nous sommes interesses au schema de surveillance de type cusum. Nous nous interessons a l'estimation de la date et de l'amplitude du dereglage sachant la detection d'une rupture par une carte cusum. Nous proposons deux methodes d'estimation de la date et de l'amplitude d'une rupture : la methode induite par la definition de la regle de decision cusum, et celle du maximum de vraisemblance. Nous etudions et comparons, pour ces deux methodes, les estimateurs de la date et de l'amplitude du dereglage apres qu'une carte cusum en ait detecte la presence. En posant l'hypothese de distribution gaussienne, nous comparons, par des simulations les estimateurs obtenus par les deux methodes en etudiant leur biais et leur ecart quadratique moyen. Nous determinons la distribution conditionnelle de l'estimateur cusum de la date du dereglage sachant sa detection par la carte cusum, ainsi que celle de l'estimateur de l'amplitude du dereglage, ainsi que leur marginale. Les densites de probabilite obtenues verifient des relations de recurrence qui se resolvent par des methodes numeriques. En posant l'hypothese de distribution gaussienne, nous obtenons de maniere theorique la distribution conditionnelle de l'estimateur du maximum de vraisemblance de la date du dereglage sachant sa detection par la carte cusum. Cependant, a cause de la complexite du domaine d'integration, nous avons eu recours a trois methodes d'integration numerique : la methode de monte-carlo, une variante de celle-ci, et une methode d'integration directe basee sur un maillage ; nous comparons ces methodes en etudiant leur vitesse de convergence. Compte tenu de la complexite des formules des distributions nous proposons une approche bayesienne empirique pour la construction de region hpd -credible de la date et de l'amplitude du dereglage et nous decrivons le logiciel que nous avons realise qui permet a un utilisateur de construire la region de confiance. Nous nous interessons ensuite au cas ou on dispose de plusieurs mesures simultanees sur le processus, il est interessant de tenir compte conjointement de toutes les informations. Nous proposons plusieurs strategies pour le faire et nous comparons leurs efficacites. Dans un dernier temps nous adaptons les resultats des distributions conditionnelles des estimateurs de la date et de l'amplitude d'une rupture dans le cas ou la carte de controle utilisee est une carte de type ewma ou ewma tronquee.
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Sako, Aichata Founé Mohamed. "Vulgarisation d’un caractère prometteur d’adaptation à la variabilité environnementale : où peut-on promouvoir le photopériodisme des variétés de mil etsorgho sous les climats actuels et futurs en Afrique de l’Ouest ?" Thesis, Paris 8, 2015. http://www.theses.fr/2015PA080099/document.
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Structurée en trois principaux chapitres, cette étude présente une approche pluridisciplinaire en combinant desanalyses spatiales et temporelles de la variabilité interannuelle des saisons de pluies d’une base de données agroclimatique,des essais phénologiques mensuelles d’une sélection de variétés photopériodiques de mil et de sorgholocales et améliorées, et l’utilisation conjointe d’un modelé de culture calibre pour les effets de la latitude et d’unSystème d’Information Géographique (SIG). Elle permet de tirer des conclusions originales et d’identifier lesenvironnements cibles prometteurs pour la vulgarisation des variétés de mil et de sorgho photopériodiques enAfrique de l’Ouest. Elle met en évidence l’existence de relations significatives entre les réponses phénologiques,le degré de sensibilité à la photopériode des variétés et les facteurs environnementaux, dont les principales sont :‒ La variabilité interannuelle des pluies en Afrique de l’Ouest durant les cinquante dernières années (1950-2000) est marquée par une diminution globale de la pluviométrie annuelle caractérisée par une variabilitéaccrue des dates de début de saison des pluies dans les latitudes basses que dans les latitudes élevées etune variabilité interannuelles des dates de fin de saison plus notable sur les latitudes du Nord plus quedans les basses latitudes au sud.‒ La distribution spatiale des variétés de mil et de sorgho photopériodiques est étroitement liée à larépartition spatiale et temporelle de la variabilité des dates de débuts et de fin de la saison de pluies. Lesvariétés photopériodiques se localisent essentiellement dans les basses latitudes ou la variabilité des datesde début de saison est plus élevée que celle des dates de fin de saison plus stable.‒ La réponse phénologique des variétés de mil et de sorgho photopériodiques est strictement dépendantede la date de semis et de la latitude. Les effets de la latitude sur la phénologie et la réactionphotopériodique des variétés est proportionnelle à la distance entre la zone de culture d’une variété et salatitude d’origine.‒ Le modèle de développement des céréales photopériodiques « Impatience » calibré et corrigé à cet effet(effet de la latitude) prévois et défini avec plus de précision les zones d’adaptation variétale optimale pourles variétés de mil et de sorgho photopériodiques en Afrique de l’Ouest.‒ L’adéquation entre la durée du cycle phénologique calibrée par le modèle de culture corrigé de l’effet dela latitude et celle observée dans les systèmes agraires à base de mil et de sorgho photopériodiques dansles agro-systèmes villageois au Mali valide le modèle les cartes d’adaptation variétale optimaleStructured in three main chapters; this study addresses multidisciplinary approach combining spatial and temporalanalysis of interannual variability of rainfall, multi-locations trials of a large and representative sample of photoperiodicvarieties of sorghum and millet combined with a photoperiod response crop model and Geographic Information System(GIS). It allowed identifying specific target environment to promote the vulgarization of photoperiodic varieties ofsorghum and millet in West Africa. This study depicted significant relationships between phenology, PP sensitivityresponses and environmental factors, where the mains components are listed below:‒ The interannual rainfall variability in West Africa over the past fifty years (1950-2000) was marked by ageneral decrease in annual rainfall characterized by high variability in the onset of growing period at lowerlatitudes and an increase in the interannual variability of the end of growing period in the northern latitudeswith least significant variability through climatic periods.‒ The spatial distribution of PP sensitivity varieties of millet and sorghum is closely related to the spatial andtemporal distribution of the interannual variability of the onset and end dates of growing period. Photoperiodsensitive varieties are located mainly at lower latitudes where the interannual variability in the onset of thegrowing period is much higher than the end of the growing period.‒ Phonological response and expression of photoperiod sensitivity are strictly dependent on sowing date andlatitude. Effects of latitude on the expression of photoperiod sensitivity and phenology are proportional tolatitude.‒ The "impatience" sub-crop model calibrated and corrected for latitudinal effect predicts and identifies moreaccurately optimal varietal adaptation areas for sorghum and millet varieties in West Africa.‒ The adequacy between calibrated duration of the phonological cycle by the crop model adjusted for latitudinaleffect and that observed in farming systems in agro-systems in Mali, allowed to validate the predicted optimalvarietal adaptation maps by defined the model
Books on the topic "Carty, Dave"
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Carty, Dave. Born again at the laundromat: And other visions of the New West. New York: Lyons & Burford, 1992.
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Johnston, Francis Claiborne. Satterfield and allied families of Person County, North Carolina and surrounding counties: (Yarbrough, Carter, Bigger, Cary, Winstead, Cozart, Bumpass, Sargent, Gold, Carney, Walker, and Davey families). Richmond, Va: F.C. Johnston, 1992.
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Forrester, Nia. A la Carte: The Complete Coffee Date Novellas. Createspace Independent Publishing Platform, 2018.
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Reyes, Spindola. Una Carta Para TI De Angel De LA Guarda/a Date With Your Guardian Angel. Edivision Compania Editorial, S.A., 1999.
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Hervey, G. Winfred. The Story Of Baptist Missions In Foreign Lands V2: From The Time Of Carey To The Present Date. Kessinger Publishing, LLC, 2007.
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Voigt, Mary M. Gordion: The Changing Political and Economic Roles of a First Millennium B.C.E. City. Edited by Gregory McMahon and Sharon Steadman. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195376142.013.0050.
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This article discusses findings from excavations at Gordion. Near the juncture of the Porsuk and Sakarya Rivers in west-central Turkey lies a large, flat-topped mound called Yass ıhöyük. In 1893 Alfred Körte visited the site, hoping to find ancient Gordion, capital of the Phrygian kingdom of the first millennium BCE. Convinced that Yass ıhöyük was the best match for descriptions left by ancient historians, Körte returned to the site in 1900 with his brother Gustav to carry out excavations on the mound and five of the surrounding tumuli. Today an identification of Yass ıhöyük as Gordion is supported by excavated remains of appropriate scale and date, and by associated inscriptions in the Phrygian language. The site has not, however, yielded inscribed material attesting the place-name Gordion, and the name of its most famous king, Midas, occurs only as a graffito on a potsherd.
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DeLisioTio, James A. Internet Password Logbook: Keep track of your Username, Password, Web addresses, Expiry Date, Telephone Number all in One Easy to Carry on with Blank ... with Colorful Butterfly Matte Cover. CreateSpace Independent Publishing Platform, 2018.
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Kaye, Alan, and Richard Urman, eds. Thoracic Anesthesia Procedures. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780197506127.001.0001.
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The Thoracic Anesthesia Procedures is a comprehensive summary of all major topics in the field. The book describes thoracic physiology and pathophysiology, airway devices and other equipment, surgical considerations, anesthetic techniques for a variety of simpler and complex procedures, ventilation techniques, postoperative care including pain management, and complications. This is a concise, up-to-date, evidence-based illustrated book for use by both trainees and practicing clinicians as a one-in-all source of evolving knowledge, techniques, and modern technology to provide care safely. The book puts an emphasis on clear, detailed anatomic drawings, latest techniques and images on topics such as the airway, neuraxial techniques, surgical techniques, and monitoring. The chapters are based on the latest published literature and are easy to read with a clinically-oriented approach providing only essential, relevant, and practical aspects of thoracic anesthesia. The book contains contributors who are national and international experts, and its compact size makes it easy to carry around in the operating room.
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Farrell, David M., and Niamh Hardiman, eds. The Oxford Handbook of Irish Politics. Oxford University Press, 2021. http://dx.doi.org/10.1093/oxfordhb/9780198823834.001.0001.
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Ireland has enjoyed continuous democratic government for almost a century, an unusual experience among countries that gained their independence in the twentieth century. But the way this works has changed dramatically over time. Ireland’s colonial past has had an enduring influence over political life, enabling stable institutions of democratic accountability, while also shaping economic underdevelopment and persistent emigration. More recently, membership of the EU has brought about far-reaching transformation across almost all aspects of life. But the paradoxes have only intensified. Now one of the most open economies in the world, Ireland has experienced both rapid growth and a severe crash in the wake of the Great Recession. By some measures, Ireland is among the most affluent countries in the world, yet this is not the lived experience for many of its citizens. Ireland is an unequivocally modern state, yet public life continues to be marked by ideas and values in which tradition and modernity are uneasy bedfellows. It is a small state that has ambitions to carry more weight on the world stage. Ireland continues to be deeply connected to Britain through ties of culture and trade, now matters of deep concern post-Brexit. And the old fault lines between North and South, between Ireland and Britain, which had been at the core of one of Europe’s longest and bloodiest civil conflicts, risk being reopened. These key issues are teased out in this book, making it the most comprehensive volume on Irish politics to date.
Book chapters on the topic "Carty, Dave"
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Richardson, Sunil, and Rakshit Vijay Sinai Khandeparker. "Cleft Rhinoplasty." In Oral and Maxillofacial Surgery for the Clinician, 1703–32. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_76.
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AbstractCleft rhinoplasty is one of the most difficult and challenging aesthetic surgeries to carry out and bears a significant impact on the overall nasal aesthetics and function. Two reasons understood for this are the simultaneous involvement of all the layers of the nose including the skin, cartilage, skeleton and vestibular lining (this being the principal reason) and the significant scarring that is the consequence of multiple previous surgical interventions. There is a mention of numerous techniques for ultimate correction of unilateral and bilateral cleft nasal deformities but no single technique has till date provided a definite solution for correction of all the problems that accompany these deformities. There is a revised interest in performing primary rhinoplasties at the time of lip repair with or without presurgical orthopedics but these procedures may still warrant definitive rhinoplasty at a later date. The purpose of this chapter is to provide a comprehensive review of cleft rhinoplasty in the most systematic manner beginning with the pathologic anatomy followed by surgical timing, pre-operative evaluation and surgical correction. The chapter also discusses the use of various grafts in a typical cleft rhinoplasty case as well as treatment strategy for management of both, unilateral and bilateral cleft nasal deformities. The outcomes as well as complications and a note on further revisions have also been presented.
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French, Elizabeth. "Chronologies should carry a ‘use by’ date:." In Athyrmata: Critical Essays on the Archaeology of the Eastern Mediterranean in Honour of E. Susan Sherratt, 81–84. Archaeopress Publishing Ltd, 2014. http://dx.doi.org/10.2307/j.ctvqmp101.14.
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Niedermeier, Silvan. "Torture and African American Courtroom Testimony." In The Color of the Third Degree, translated by Paul Cohen, 39–58. University of North Carolina Press, 2019. http://dx.doi.org/10.5149/northcarolina/9781469652979.003.0003.
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Chapter two focuses on the Dave Canty case and the Daniels-Robinson case. The two cases shows how allegations of torture were dealt with during criminal proceedings and examines the means used by African American suspects to substantiate allegations of torture during their trials. Overall, this chapter examines the testimonies of African American defendants and the degree to which their statements were recognized by the courts of the South.
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Jahner, Jennifer. "Coda." In Literature and Law in the Era of Magna Carta, 217–28. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198847724.003.0006.
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The conclusion to the book expands the terrain of “jurisdictional poetics” to include both contemporary and medieval poetry. It begins with the work of Carter Revard, Osage poet and medievalist, whose discovery of the scribe of Harley 2253 has fundamentally shaped contemporary scholarship on legal and literary copying in later medieval England. His poem “Starring America” provides an entry point into the tensions between epic and local histories that resonate as well in a set of cross-Channel satires that date to the time of the Second Barons’ War. The coda examines the earliest surviving Middle English sirventes, “Richard of Almaigne,” alongside two French satires on the English revolt, the Pais aus Englois and La chartre de la pais aus Englois. In both cases, language difference serves as a synecdoche for territorial dominion, parsing the boundaries between political desire and legal authority.
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Glancy, Mark. "Chapter 23." In Cary Grant, the Making of a Hollywood Legend, 313–26. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190053130.003.0024.
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To help Betsy Drake’s flagging career, Grant agreed to do a radio series with her. Mr and Mrs Blandings (1951) continued the comical adventures that began in Mr Blandings Builds His Dream House (1948), but the series was not well received. On screen, he took some risks in this period, playing an outspoken doctor in the politically charged People Will Talk (1952), and an ordinary family man in the gentle comedy Room for One More (1952). He also returned to the more familiar terrain of screwball comedy. Howard Hawks’ Monkey Business (1952), co-starring Ginger Rogers and Marilyn Monroe, allowed him some fine comic moments, but Dream Wife (1953), co-starring Deborah Kerr, seemed tired and old-fashioned. None of these films scored with audiences. Seeing the rising popularity of young method actors such as Marlon Brando, Grant began to wonder if his own debonair image was out of date, and if it was time for him to retire.
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Olson, Kory. "The Rise of Suburban Paris." In The Cartographic Capital, 221–67. Liverpool University Press, 2018. http://dx.doi.org/10.3828/liverpool/9781786940964.003.0007.
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This chapter examines the 1934 Carte générale de l’aménagement de la Région parisienne (Carte générale), a brightly-coloured, multi-page representation of Paris and its suburbs. Parliament passed ‘la loi du 14 mars 1932’ which officially defined ‘la région parisienne’ geographically as the area within a thirty-five-kilometre radius from the ‘parvis Notre Dame.’ A forty-member commission chose Prost’s Carte générale and named him Urbaniste en chef. Prost’s map, the last officially approved cartographic proposal for the capital under the Third Republic recognized the changing nature of early-twentieth century cities, where the automobile enhanced personal movement and overwhelmed nineteenth-century infrastructure. Reinforcing the desire to both know and control the growing region and address current transportation infrastructure inadequacies, Prost highlights new autoroutes and clearly delineates – geographically – where the region ends. Prost acknowledged the growing presence of the banlieue (suburb). He followed Jaussely’s lead and documented future development and existing green space. Prost also suggests controlling urban growth. This chapter investigates how Henri Prost’s Carte générale demonstrates the government’s desire to move beyond the ideals of urbanism in Jaussely’s 1919 Plan. Prost provides a much more realistic plan to address the region’s needs.
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Klamert, Marcus, Manuel Kellerbauer, and Jonathan Tomkin. "Title IV Provisions on Enhanced Cooperation." In The EU Treaties and the Charter of Fundamental Rights. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198759393.003.25.
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Differences between MS’ willingness or capability to proceed on the common path to an ‘ever closer Union’ have existed since the creation of the EEC. First reflections on how to avoid that this heterogeneity slows down the integration process date back to the 1970s. The then divergence of MS’ economic and financial situations prompted suggestions that MS that are able to progress towards an economic and monetary union should have a duty to forge ahead, whilst those left behind should receive assistance to catch up. In the ensuing decades, it was first and foremost the different political visions for the future of the Union that fuelled discussions about types of differentiated integration for which terms such as ‘multi-speed Europe’, ‘Europe à la carte’, or ‘closer cooperation’ were coined.
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Kahn, Richard J. "“Alkaline Doctor” and “A Dangerous Innovator”." In Diseases in the District of Maine 1772 - 1820, 87–117. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190053253.003.0004.
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In 1795 Barker read Lavoisier’s chemistry, experimented on tainted meat made edible by soaking in alkalis, and began using alkaline therapy such a limewater. He wrote about this to Samuel Mitchill and Benjamin Rush, telling them that he had been called a “dangerous innovator.” A brief history of the acid/alkali debates of the seventeenth and eighteenth centuries includes information about Otto Tachenius, John Colbatch, Hermann Boerhaave, George Ernst Stahl, William Cullen, Joseph Black, and Antoine Lavoisier. Barker wrote about his experiments, azotic air (nitrogen), and his difficulty understanding the mechanism of this apparently successful therapy. His results were published in the Medical Repository, beginning a correspondence with Samuel Latham Mitchill, professor of chemistry at Columbia University. Contributors to the discussion of alkalis included David Hosack, Thomas Beddoes and James Watt, Humphry Davy, and Matthew Carey. Comments by Charles Rosenberg, John Harley Warner, Lester King, and others help us make sense of medical science and the acid/alkali battle.
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Schmid, Christopher H., Gavin B. Stewart, Hannah R. Rothstein, Marc J. Lajeunesse, and Jessica Gurevitch. "Software for Statistical Meta-analysis." In Handbook of Meta-analysis in Ecology and Evolution. Princeton University Press, 2013. http://dx.doi.org/10.23943/princeton/9780691137285.003.0012.
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To conduct a meta-analysis, a researcher will need software to perform all but the simplest calculations. Three types of software can be used, depending on user needs: a spreadsheet, a general purpose statistical package, and a program developed expressly to carry out meta-analysis. This chapter first reviews the stand-alone programs, then discusses the general purpose software, and finally briefly reviews two programs that can extract the data underlying a graphical display. Readers need to keep in mind that software features, cost, and availability all change fairly rapidly over time; while some of the specific information provided may soon be out of date, the general issues and principles discussed in choosing software for meta-analysis will have a longer half-life. Web searches, the Methods sections of recent research syntheses, and professional meetings where research synthesis results and methods are presented, are good resources for keeping up with both software availability and developments in methodology.
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Musitha, Mavhungu Elias. "Immigration Is a Nucleus of Economic Development in Africa." In Advances in Religious and Cultural Studies, 210–23. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-7099-9.ch012.
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This chapter demystifies the world view that holds that immigration is motivated by poor people who become the burden to the host countries. It has unearthed that poverty is just a manifestation of a bigger issue which is underdevelopment. Underdevelopment causes migration because the livelihood has been colonised and neo-colonialism continues doing that to this date. This underdevelopment gave rise to poverty, unemployment, inequality, and poor governance. Therefore, immigration is hugely influenced by underdevelopment. Migrants carry along entrepreneurship skills which they also transfer to host countries. However, they also face challenges in the host countries such as discrimination in the allocation of resources such as health and education. The host citizens fear the competition from the new people who have arrived in their country. The African Union should discuss the development of the continent and resolve the underdevelopment through the natural resources the continent has instead of taking it to Europe to perpetuate the notion of underdevelopment.
Conference papers on the topic "Carty, Dave"
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Kai Du, P. Varman, and K. Mohanram. "High performance reliable variable latency carry select addition." In 2012 Design, Automation & Test in Europe Conference & Exhibition (DATE 2012). IEEE, 2012. http://dx.doi.org/10.1109/date.2012.6176685.
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Lau, Mark S. K., Keck-Voon Ling, Yun-Chung Chu, and Arun Bhanu. "A general mathematical model of probabilistic ripple-carry adders." In 2010 Design, Automation & Test in Europe Conference & Exhibition (DATE 2010). IEEE, 2010. http://dx.doi.org/10.1109/date.2010.5456973.
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Boroumand, Sina, Hadi P. Afshar, and Philip Brisk. "Approximate quaternary addition with the fast carry chains of FPGAs." In 2018 Design, Automation & Test in Europe Conference & Exhibition (DATE). IEEE, 2018. http://dx.doi.org/10.23919/date.2018.8342073.
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Yu, Shengqi, Ahmed Soltan, Rishad Shafik, Thanasin Bunnam, Fei Xia, Domenico Balsamo, and Alex Yakovlev. "Current-Mode Carry-Free Multiplier Design using a Memristor-Transistor Crossbar Architecture." In 2020 Design, Automation & Test in Europe Conference & Exhibition (DATE). IEEE, 2020. http://dx.doi.org/10.23919/date48585.2020.9116417.
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Egorov, Gennadiy V., Alexandr E. Nilva, and Andrey A. Solovyov. "Influence of Longitudinal Members Partially Missing to the Operative Vessel Residual Strength Calculations for Emergency Response Service." In ASME 2007 26th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2007. http://dx.doi.org/10.1115/omae2007-29042.
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In accordance with up-to-date IMO requirements it’s necessary to create shore organizations that are able to carry out damage stability and residual structural strength calculations for a damaged vessel. The paper is based on simple elastic analysis to calculate the residual strength of the damage vessel under various damage scenarios.
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Внук, Вячеслав, Vyacheslav Vnuk, Евгений Ипполитов, Evgeniy Ippolitov, Михаил Новиков, Mihail Novikov, Светлана Черебыло, and Svetlana Cherebylo. "Application of computer-aided design systems and additive technologies in reconstructive surgery." In 29th International Conference on Computer Graphics, Image Processing and Computer Vision, Visualization Systems and the Virtual Environment GraphiCon'2019. Bryansk State Technical University, 2019. http://dx.doi.org/10.30987/graphicon-2019-1-176-180.
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This work summarizes the experience of using modern methods of radiation diagnostics in combination with computer and telecommunication technologies in planning reconstructive operations in neurosurgical and maxillofacial practice. Modern medicine does not stand still, it is constantly developing and improving. Thanks to the emergence of high-tech medicine today, it is possible to carry out complex surgical operations and to give a person who has faced serious injury, to continue a fairly high-quality and full life. The creation of a digital model and the use of computer simulation using the data of a particular patient, was a real breakthrough in medicine, because this technology is very quickly found its practical use in many areas of surgery. To date, this approach in the planning of reconstructive surgery has already been tested in many medical institutions and makes a significant contribution to the development of modern medicine.
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Merzari, Elia, Paul Fischer, and Justin Walker. "Large-Scale Simulation of Rod Bundles: Coherent Structure Recognition and Stability Analysis." In ASME/JSME/KSME 2015 Joint Fluids Engineering Conference. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/ajkfluids2015-29719.
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The axial flow in rod bundles has been the object of several investigations, since they are relevant for various industrial applications (e.g., heat exchangers, nuclear reactor cores). For tight configurations (pitch-to-diameter ratio smaller than 1.1) the large difference in velocity within the cross section creates the possibility of a Kelvin-Helmholtz instability and the generation of a vortex street in the gap (“gap instability”). While the presence of spacing devices may perturb the flow, simple grid spacers — grids of the type usually encountered in sodium fast reactors — do not prevent this instability. This work seeks to improve our understanding of the gap instability in large rod bundles by using high-fidelity large-eddy simulation (LES). The application of LES methods has been historically limited to single-pin calculations because of the large cost of full-bundle calculations. However, using Nek5000, a massively parallel spectral-element computational fluid dynamics code, we are able to carry out well-resolved LES simulations for this class of geometries. Results are compared with experimental data. For the largest bundle case, over 8 billion collocation points at a polynomial order of 20 are judged necessary to achieve overall excellent accuracy. More than 500,000 processors are used to carry out the simulations (costing approximately 50,000,000 CPU-hours), and 3,000 snapshots of the flow field have been collected to apply several coherent structure recognition techniques, including one of the largest proper orthogonal decompositions carried out to date. Also investigated here is the effect of geometry, including the (presence of spacers, changing pitch-to-diameter ratio, and canister wall. In particular, global linear stability analysis is applied to a series of simplified geometries in order to gain insight into the physics of the gap instability.
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Laskowski, Christina, and Stephen Derby. "Fuel Cell ASAP: Two Iterations of an Automated Stack Assembly Process and Ramifications for Fuel Cell Design-for-Manufacture Considerations." In ASME 2009 International Manufacturing Science and Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/msec2009-84104.
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Polymer-electrode membrane (PEM) fuel cell technology will need to progress from low-volume production to high-volume within the course of the next decade. To successfully achieve this transition, a fully-functional fuel cell automatic stack assembly robotic station is being developed. This document outlines both iterations of the robotic fuel cell assembly stations, other work to date, DFM and DFA lessons learned, and the anticipated future progression of automatic fuel cell stack assembly stations. Two individual robotic fuel cell assembly stations were constructed, including custom-built end effectors and parts feeders. The second station incorporated numerous improvements, including overlapping work envelopes, elimination of a shuttle cart, software synchronization, fewer axes, and a better end effector. Consequentially, the second workcell achieved a four-fold improvement in cycle time over the previous iteration. Future improvements will focus in part upon improving the reliability of the overall system. As the stack assembly workcell continues to improve, research will focus upon the ramifications and interplay of tolerances, stack failure modes, sealing, reliability, and the potential for component redesign specifically to optimize fuel cell manufacturing throughput.
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Çiftçi, Hakkı. "Economic Cooperation in the World and Utopian Eurasia." In International Conference on Eurasian Economies. Eurasian Economists Association, 2019. http://dx.doi.org/10.36880/c11.02314.
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In the first part of this study, Economic Cooperation and Utopian Eurasia, the main characteristics of the new collaborations in the world, the concept of economic cooperation, the effects of the elements, the economic cooperation, the characteristics of structural adjustment, the global market targets with the economic cooperation, the adaptation possibilities and problems of the economic cooperation will be explained. Based on the Eurasian concept, the basic population, economic structure and development potential of the Eurasian Economic Union will be discussed. In the third and the last part, together with the transformations in the world, which carry the confrontational processes, it will be included in the contemporary communication to achieve the success of the economic cooperation by means of the common communication network and the changes in the areas where the rapid change between the political, economic, cultural, technological and social decision-making centers become up-to-date. the necessity of being equipped with sufficient information about economic associations and developments, the success of the country in the field of economy, the changes and developments occurring in the world will be evaluated in the context of Eurasian economic cooperation and the results and suggestions will be made.
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Kuzlyakina, Valentina V., and Marina V. Nagaeva. "Computer-Aided Laboratory Work to “Mechanism and Machine Science” Course." In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-34609.
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Laboratory work is an important element in engineering training, which should correspond to up-to-date tendencies in computer-based technologies in design, production, maintenance and preserving mechanisms. Computer-based laboratory work consists of 16 assignments. Seven assignments are carried out on laboratory stands, the remainder are provided on PC, using programs like “Visual Structure Editor”, “DYNAMO”, “APM Win Machine”. The system Visual Structure Editor (VSE) is designed by specialists of “Machine Mechanics and Computer-Aided Design” department, of the Maritime State University named after adm.G.I.NEVELSKOY, Vladivostok, under the direction of prof. Valentina V. Kuzlyakina. The system APM (Automated Projecting of Mechanism) is designed by the research-and-production centre “APM” under the direction of prof.V.Shelofast, from the city of Korolyov, Moscow area. These systems are multifunctional. They allow project different mechanical systems at the stage of structural and parametrical synthesis, carry out strength calculations and design elements of machines and mechanisms. They are good in operation. Teachers and students easily master the systems. Laboratory works with computer support allow students to pass from a concrete object to modeling on a PC, and to solve complex engineering tasks during the education process.