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Journal articles on the topic 'CAS PO 223'

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Published: 27 July 2024

Last updated: 31 July 2025

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1

Karve, Kunal, Stephanie Poon, Panagiotis Prinos, and Laurie Ailles. "Abstract PO-077: High-throughput 3D-spheroid invasion assay: A powerful tool to identify novel drugs targeting tumor micro-environment in HNSCC." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—077—PO—077. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-077.

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Abstract Cancer metastasis is a complex cascade that involves activation of cancer cell invasion and migration. This activation is greatly attributed by multiple factors, including the tumor-microenvironment (TME). Cancer-associated fibroblasts (CAF), a prominent cell type within the TME, have been shown to promote cancer cell invasion and migration, causing metastasis in various cancers including head and neck squamous cell carcinoma (HNSCC). The molecular mechanisms of how CAFs promote HNSCC invasion remain elusive. Our research goal is to understand how CAFs influence HNSCC cells to become

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Rothberg, Brad S., and Karl L. Magleby. "Voltage and Ca2+ Activation of Single Large-Conductance Ca2+-Activated K+ Channels Described by a Two-Tiered Allosteric Gating Mechanism." Journal of General Physiology 116, no. 1 (2000): 75–100. http://dx.doi.org/10.1085/jgp.116.1.75.

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The voltage- and Ca2+-dependent gating mechanism of large-conductance Ca2+-activated K+ (BK) channels from cultured rat skeletal muscle was studied using single-channel analysis. Channel open probability (Po) increased with depolarization, as determined by limiting slope measurements (11 mV per e-fold change in Po; effective gating charge, qeff, of 2.3 ± 0.6 eo). Estimates of qeff were little changed for intracellular Ca2+ (Ca2+i) ranging from 0.0003 to 1,024 μM. Increasing Ca2+i from 0.03 to 1,024 μM shifted the voltage for half maximal activation (V1/2) 175 mV in the hyperpolarizing directio

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Saeki, Toshiaki, Tadashi Nomizu, Masakazu Toi, et al. "Dofequidar Fumarate (MS-209) in Combination With Cyclophosphamide, Doxorubicin, and Fluorouracil for Patients With Advanced or Recurrent Breast Cancer." Journal of Clinical Oncology 25, no. 4 (2007): 411–17. http://dx.doi.org/10.1200/jco.2006.08.1646.

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Purpose To evaluate the efficacy and tolerability of dofequidar plus cyclophosphamide, doxorubicin, and fluorouracil (CAF) therapy in comparison with CAF alone, in patients with advanced or recurrent breast cancer. Dofequidar is a novel, orally active quinoline derivative that reverses multidrug resistance. Patients and Methods In this randomized, double-blind, placebo-controlled trial, patients were treated with six cycles of CAF therapy: 28 days/cycle, with doxorubicin (25 mg/m2) and fluorouracil (500 mg/m2) administered on days 1 and 8 and cyclophosphamide (100 mg orally [PO]) administered

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Reeves, W. B., and R. W. Gurich. "Calcium-dependent chloride channels in endosomes from rabbit kidney cortex." American Journal of Physiology-Cell Physiology 266, no. 3 (1994): C741—C750. http://dx.doi.org/10.1152/ajpcell.1994.266.3.c741.

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Ion channels in endosomal membranes from rabbit kidney cortex were studied after reconstitution into planar lipid bilayers. The most frequently observed ion channel was anion selective (PCl/PK = 13) and had a single-channel conductance of 116 pS when the cis and trans solutions contained 410 and 150 mM KCl, respectively, and a conductance of 90 pS in symmetrical 150 mM KCl solutions. The anion selectivity sequence of the channel was NO3- > F- > Br- > Cl- >> I-. The activity of the channel was voltage dependent such that hyperpolarization of the cis, or cytoplasmic, surface of th

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Chen, Ren-Shiang, Yanyan Geng, and Karl L. Magleby. "Mg2+ binding to open and closed states can activate BK channels provided that the voltage sensors are elevated." Journal of General Physiology 138, no. 6 (2011): 593–607. http://dx.doi.org/10.1085/jgp.201110707.

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BK channels are activated by intracellular Ca2+ and Mg2+ as well as by depolarization. Such activation is possible because each of the four subunits has two high-affinity Ca2+ sites, one low-affinity Mg2+ site, and a voltage sensor. This study further investigates the mechanism of Mg2+ activation by using single-channel recording to determine separately the action of Mg2+ on the open and closed states of the channel. To limit Mg2+ action to the Mg2+ sites, the two high-affinity Ca2+ sites are disabled by mutation. When the voltage is stepped from negative holding potentials to +100 mV, we find

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Ho, Alan L., Douglas R. Adkins, Jochen Lorch, Jacob S. Thomas, and Jaspreet S. Grewal. "Abstract PO-007: A phase 2 open-label study of conditionally active biologic, ozuriftamab vedotin (BA3021) in PD-1/L1 failure patients with recurrent or metastatic squamous cell carcinoma of the head and neck." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—007—PO—007. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-007.

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Abstract Background: Ozuriftamab vedotin (BA3021) is a conditionally active biologic (CAB) anti-receptor tyrosine kinase orphan receptor 2 (ROR2) humanized monoclonal antibody (IgG1) conjugated to monomethyl auristatin E (MMAE) using a cleavable linker (CAB ROR2 ADC) (Short, et al., 2014, Chang, et al. 2021). Conditional and reversible binding by CABs is designed to reduce off-tumor toxicity and immunogenicity, avoid tissue-mediated drug deposition, and improve pharmacokinetics (PK). ROR2 is a cell-surface transmembrane receptor protein tyrosine kinase highly expressed in several tumor types i

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Fassinou, Nonvignon Martial, Fadéby Modeste Gouissi, Souradjou Orou Goura, et al. "Impacts de la Contamination Agricole sur la Qualité Physicochimique des Eaux de Surface de l’Ouémé Supérieur au Bénin." European Scientific Journal, ESJ 19, no. 9 (2023): 102. http://dx.doi.org/10.19044/esj.2023.v19n9p102.

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Le présent travail vise à apprécier la qualité physico-chimique des eaux de l’Ouémé supérieur au Bénin. L’étude concerne quatre (04) communes. Les données ont été collectées en octobre 2021 et en mars 2022. Les paramètres physiques in-situ et les paramètres chimiques au laboratoire ont été étudiés. La description par les box plots (Boîtes à moustaches), le test de Shapiro-Wilk et celui de Kruskall Wallis au seuil α = 5% ont été utilisés. Les paramètres tels la salinité, T°C,〖 NO〗_2^-, NO_3^-, NH_4^+, PO_4^(3-), Ca2+, Mg2+, Fe2+ et le Cl- sont significativement différents des autres paramètres

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Gil, Adam. "Ograniczenia współczesnych generatorów obrazów opartych o AI w procesie projektowania architektonicznego." BUILDER 320, no. 3 (2024): 28–33. http://dx.doi.org/10.5604/01.3001.0054.3459.

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Wraz z wprowadzeniem narzędzi CAD, a potem BIM, architekci zaczęli dostrzegać, że narzędzia, których używają, mają wpływ na ich twórczość. Obecnie architekci zaczynają używać narzędzi AI umożliwiających eksplorację koncepcji projektowych poprzez generowanie obrazów. Te narzędzia, zwane generatorami obrazów AI, generują obrazy na podstawie opisów tekstowych oraz dowolnych wczytanych obrazów, w tym szkiców lub zdjęć. Na rynku dostępne są zarówno narzędzia przeznaczone bezpośrednio do projektowania architektonicznego, jak i narzędzia o charakterze ogólnym, służące do generowania dowolnych obrazów

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Perrone, R., P. Vadhana Ashok Kumaar, K. Gore, J. Favret, E. Verdin, and S. Felstead. "POS1022 A NEWLY DEVELOPED SMALL MOLECULE CD38 INHIBITOR EXERTS THERAPEUTIC EFFECTS IN A COLLAGEN-INDUCED ARTHRITIS MOUSE MODEL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 828.1–828. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5084.

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BackgroundCD38 is a NAD+ consuming enzyme ubiquitously expressed on immune cells and its expression increases in several pathological conditions, including Rheumatoid Arthritis (RA) [1, 2]. Pre-clinical studies in CD38knock-outmodels have demonstrated that CD38 deficient animals develop an attenuated form of Collagen-Induced-Arthritis (CIA) characterized by reduced inflammation and damage at the joint level suggesting a causal role of CD38 in the pathogenesis of CIA and, potentially, RA [3-5].ObjectivesThis study investigated the efficacy of NTX-748, a newly developed, potent and orally availa

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Masuda, Muneyuki, Hirofumi Omori, Kuniaki Sato, Josef Penninger, and Silvio Gutkind. "Abstract PO-063: Environment-induced YAP1 transcriptional reprogramming drives head and neck cancer." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—063—PO—063. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-063.

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Abstract Background: The biology of head and neck cancer (HNC) has been explained by the field carcinogenesis theory in which accumulated abnormalities (mainly gene mutations) caused by environmental stresses promote carcinogenesis. However, as clearly demonstrated by recent studies (Yokoyama et.al, Nature 2019; Hedberg et.al, JCI 2016), the genetic landscape of HNC (i.e., the loss-of-function mutations in tumor suppressor genes) fails to account for the onset and metastatic ability of HNC. In addition to being mutagen, environmental stresses induce oncogenic transcriptional programs (e.g., ti

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Nissa, Yulia Khalifatun, I. Gusti Agung Gde Putra Pemayun, and Anak Agung Gde Jayawardhita. "Laporan Kasus: Keberhasilan Penanganan Vulnus Morsum Stadion III dan IV pada Kucing Lokal." Indonesia Medicus Veterinus 12, no. 6 (2024): 861–72. http://dx.doi.org/10.19087/imv.2023.12.6.861.

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Vulnus morsum adalah luka yang disebabkan oleh gigitan. Vulnus morsum yang tidak ditangani secara cepat dan tepat dapat menimbulkan infeksi. Seekor kucing lokal betina steril berumur satu tahun dengan bobot badan 2,3 kg diperiksa karena adanya luka gigitan pada daerah tulang belikat bagian kiri yang telah berlangsung lebih dari dua minggu. Hasil pemeriksaan klinis menunjukkan adanya dua luka terbuka, salah satu luka sudah mengalami nekrosis dan luka lainnya terlihat dalam. Mukosa mulut tampak pucat dengan capillary fill time (CRT) lebih dari dua detik, serta nafsu makan dan minum yang berkuran

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12

Giani, Michele, Nives Ogrinc, Samo Tamše, and Stefano Cozzi. "Elevated River Inputs of the Total Alkalinity and Dissolved Inorganic Carbon in the Northern Adriatic Sea." Water 15, no. 5 (2023): 894. http://dx.doi.org/10.3390/w15050894.

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The response of coastal systems to global acidification depends strongly on river inputs, which can alter the total alkalinity (AT) and dissolved inorganic carbon (DIC) in seawater. The northern Adriatic Sea (NAd) is a shallow continental shelf region that currently receives about 15% of the total freshwater input in the Mediterranean Sea, where the role of riverine discharges on the carbonate system has been poorly studied. In particular, river discharges can alter the carbonate system in the sea, affecting both the equilibrium chemistry and biological processes. For the main rivers flowing i

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13

Jonah, U. E., and I. I. Akpan. "Characterization of physicochemical parameters and insect composition in a reservoir in Northern Akwa Ibom State, Nigeria." Ceylon Journal of Science 53, no. 3 (2024): 303–12. http://dx.doi.org/10.4038/cjs.v53i3.8174.

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This study was conducted in a reservoir located in Mbiabet Ikot Udo community, Northern Akwa Ibom State, Nigeria, to assess the physicochemical status, composition and abundance of aquatic insects. Samples were collected from June 2022 to January 2023 and all the parameters were evaluated using standard methods. The results revealed that temperature ranged from 22.7 to 30.6°C, TDS (153 – 238 mgL-1), EC (153 – 238μScm-1), TDS (97.9 –152.3mgL-1), pH (6.3 – 8.1), DO (2.22 – 5.14 mgL-1), TSS (1.62 – 6.34 mgL-1), NO-3 (1.53 – 5.68 mgL-1), PO-4 (2.18 – 4.16 mgL-1), Mg2+ (3.92 – 5.36 mgL-1), Ca2+ (5.

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Demelash, Abebaw, Abunu Atlabachew, Muralitharan Jothimani, and Abel Abebe. "Hydrogeochemical Characterization and Appraisal of Groundwater Quality in Yisr River Catchment, Blue Nile River Basin, Ethiopia, by Using the GIS, WQI, and Statistical Techniques." Journal of Chemistry 2023 (April 18, 2023): 1–28. http://dx.doi.org/10.1155/2023/8199000.

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Groundwater is a primary drinking, agricultural, domestic, and nondomestic water source in Ethiopia’s Yisr River watershed of the Blue Nile River basin. There has been no systematic investigation of the hydrogeochemical properties of groundwater in the research area. The study investigated the hydrogeochemical parameters of groundwater in the catchment to find out if it is fit for drinking and irrigation. A total of 26 samples of groundwater were collected and analyzed for seventeen parameters, including pH, temperature, EC, TDS, TH, K+, Na+, Ca2+, Mg2+, Fe2+, Cl−, HCO 3 − , CO 3 2 − , SO 4 2

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Shen, Xiangfeng, Katherine Gonzalez, Rico Castillo, Ashlyn Rickard, Yvonne Mowery, and Tammara Watts. "Abstract PO-093: Crenolanib improves PD-1 response and overall survival in immune checkpoint inhibitor resistant murine models of oral squamous cell carcinoma." Clinical Cancer Research 29, no. 18_Supplement (2023): PO—093—PO—093. http://dx.doi.org/10.1158/1557-3265.aacrahns23-po-093.

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Abstract Background: Present line indications for pembrolizumab are for patients with metastatic or unresectable recurrent (i.e. incurable) head and neck squamous cell carcinoma (HNSCC). However, only a minority of patients on immunotherapy will realize a durable survival benefit because &gt;80% of patients with metastatic HNSCC do not respond to PD-1 blockade. Tumor microenvironment mesenchymal stem cells (MSCs) and cancer associated fibroblasts (CAFs) have been reported significantly contribute to chemotherapy and radiation resistance. Moreover, MSCs have been shown to contribute to an i

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Singh, Samara P., Austin R. Dosch, Siddharth Mehra, et al. "Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer." Cancer Research 84, no. 2_Supplement (2024): C025. http://dx.doi.org/10.1158/1538-7445.panca2023-c025.

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Abstract Introduction: The desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) perpetuates therapeutic resistance by impairing drug delivery and effector immune cell infiltration and activation. We have identified tumor cell-derived interleukin-1α (IL1α) as a critical activator of the stroma, comprised of cancer-associated fibroblasts (CAF), towards a pro-inflammatory phenotype via the IL1 receptor, IL1R1, and subsequent activation of p38 MAPK. Our hypothesis is that disruption of the CAF-specific IL1α/p38 MAPK signaling axis can improve chemotherapeutic resistance by remodeling the

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Carter, Bing, Po Yee Mak, Wenjing Tao, et al. "Abstract A08: Targeting HSP90 epichaperome in TP53 mutant AML." Blood Cancer Discovery 4, no. 3_Supplement (2023): A08. http://dx.doi.org/10.1158/2643-3249.aml23-a08.

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Abstract The Bcl-2 inhibitor venetoclax (VEN)/hypomethylation agent (HMA) combination achieves high response rates, has improved outcomes for many patients with AML and is now considered standard of care for patients who are older or unfit to receive intensive chemotherapy. However, the median overall survival is only 14.7 months on this regimen and only 2.5 months post relapse. Molecular analysis demonstrates that mutations in TP53 and oncogenic kinases are key determinants of lower response rates and early relapse. Preclinical studies also show that increased kinase signaling in AML stem/pro

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18

Lopes, Andréa Roloff. "Voltaire: Nascimento dos intelectuais no Século das Luzes." História: Questões & Debates, Curitiba 13, no. 25 (1996): 219–28. https://doi.org/10.5281/zenodo.7271343.

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  A obra de Lepape é um bom exemplo de biografia histórica. Ao longo de dezenove capítulos ele narra a história da vida de Voltaire, relacionando-a com a sociedade francesa do período. Durante o século XVIII aconteceram muitas mudanças políticas e sociais na França, as quais, numa relação de interdependência, interferiram na transformação do ofício do intelectual, remetendo-o a uma função de crítico da sociedade. Buscando ilustrar e concretizar este processo, Lepape

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Gui, Yuheng, Xiaohe Shi, Caihua Huang, Shenghui Yi, and Donghai Lin. "PO-304 Caffeine Supplementation Altered Metabolic Profiles in High-intensity Interval Training." Exercise Biochemistry Review 1, no. 5 (2018). http://dx.doi.org/10.14428/ebr.v1i5.13363.

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Objective Caffeine supplementation is a commonly used nutritional practice. Exogenous metabolites from caffeine, such as paraxanthine, theobromine and theophylline, are eventually excreted through urine. Yet, it is less clear whether caffeine would induce endogenous metabolites altered during exercise. Urine metabolomics is non-invasive method, which mainly focus on alterations of endogenous metabolic profiles caused by diseases, drugs, and lifestyle and nutritional interventions as well. Therefore, the purpose of the present study was to examine the effects of supplementation with caffeine in

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20

Puravet, Antoine, Benjamin Rieu, Camille Phere, et al. "Impact of storage temperature and time before analysis on electrolytes (Na⁺, K⁺, Ca²⁺), lactate, glucose, blood gases (pH, pO₂, pCO₂), tHb, O₂Hb, COHb and MetHb results." Clinical Chemistry and Laboratory Medicine (CCLM), April 21, 2023. http://dx.doi.org/10.1515/cclm-2023-0162.

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Abstract Objectives The objective of our study is to evaluate the effect of storage temperature and time to analysis on arterial blood gas parameters in order to extend the CLSI recommendations. Methods Stability of 12 parameters (pH, pCO₂, pO₂, Na+, K+, Ca2+, glucose, lactate, hemoglobin, oxyhemoglobin, carboxyhemoglobin, methemoglobin) measured by GEM PREMIER™ 5000 blood gas analyzer was studied at room temperature and at +4 °C (52 patients). The storage times were 30, 45, 60, 90 and 120 min. Stability was evaluated on the difference from baseline, the difference from the analyte-specific me

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Nasir, Mehwish Huma, Hajira Niaz, Naila Yunus, et al. "Calcium-, magnesium-, and yttrium-doped lithium nickel phosphate nanomaterials as high-performance catalysts for electrochemical water oxidation reaction." Nanotechnology Reviews 13, no. 1 (2024). http://dx.doi.org/10.1515/ntrev-2023-0166.

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Abstract Electrochemical water oxidation reaction (WOR) lies among the most forthcoming approaches toward eco-conscious manufacturing of green hydrogen owing to its environmental favors and high energy density values. Its vast commoditization is restricted by high-efficiency and inexpensive catalysts that are extensively under constant research. Herein, calcium, magnesium, and yttrium doped lithium nickel phosphate olivines (LiNi1−x M x PO, LNMP; x = 0.1–0.9; M = Ca2+, Mg2+, and Y3+) were synthesized via non-aqueous sol-gel method and explored for catalytic WOR. Lithium nickel phosphates (LNP)

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Reis, Bruna de Oliveira, Glívia Queiroz Lima, Ana Teresa Maluly-Proni, et al. "Desenvolvimento clínico e estágio atual da odontologia adesiva." ARCHIVES OF HEALTH INVESTIGATION 8, no. 6 (2019). http://dx.doi.org/10.21270/archi.v8i6.3808.

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Introdução: O maior foco das pesquisas odontológicas nos últimos 60 anos tem sido a adesão e suas técnicas. Mais de 7000 artigos já foram publicados a este respeito. O desenvolvimento dos materiais odontológicos adesivos e as técnicas a eles relacionadas possuem uma história interessante, onde descobertas do passado ainda são usadas de alguma forma no presente. Objetivo: expor, através de uma revisão de literatura, um breve histórico sobre materiais e técnicas restauradoras, bem como o estágio atual da odontologia adesiva, com ênfase na tradução de evidências baseadas em pesquisas laboratoriai

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Khalid, Raza1* and Rajni Jaiswal2. "RECONSTRUCTION AND ANALYSIS OF CANCERSPECIFIC GENE REGULATORY NETWORKS FROM GENE EXPRESSION PROFILES." June 27, 2013. https://doi.org/10.5121/ijbb.2013.3203.

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International Journal on Bioinformatics & Biosciences (IJBB) Vol.3, No.2, June 2013 DOI: 10.5121/ijbb.2013.3203 27 RECONSTRUCTION AND ANALYSIS OF CANCERSPECIFIC GENE REGULATORY NETWORKS FROM GENE EXPRESSION PROFILES Khalid Raza1* and Rajni Jaiswal2 1Department of Computer Science, Jamia Millia Islamia (Central University), New Delhi-110025, India. kraza@jmi.ac.in 2Department of Computer Science, Jamia Hamdard, New Delhi-110062, India. ABSTRACT The main goal of Systems Biology research is to reconstruct biological networks for its topological analysis so that reconstructed networks can be u

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