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1

Kovaľová, Alžbeta. "Kvantifikace turbulence pomocí ekvivalentního teplotního gradientu." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2021. http://www.nusl.cz/ntk/nusl-442412.

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The diploma thesis is focused on the optical beam propagating in the atmosphere in a wireless communication optical link. The first part of the work explains the atmospheric transmission media with turbulence and its effects on reliability of the optical system. The second part introduces methods for turbulence determination based on a statistical approach to turbulence quantification are introduced. In the third part, method of equivalent temperature gradient is described with the advantage of immediate turbulence evaluation. The output of this thesis is the model of turbulent environment for
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2

Er, Sarp. "Structure interne, transfert turbulent et propriétés de cascade de l'interface turbulent/non-turbulent d'un jet turbulent." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILN048.

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L'interface turbulent/non-turbulent (TNTI) est une couche très fine entre les régions turbulentes et non turbulentes de l'écoulement. Cette étude vise à mieux comprendre le bilan d'énergie cinétique au voisinage de l'interface turbulent/non-turbulent. L'équation de Kármán-Howarth-Monin-Hill (KHMH) est utilisée pour caractériser le bilan énergétique cinétique local, y compris les transferts d'énergie dans l'espace et entre les échelles. L'analyse est effectuée à l'aide de données obtenues par simulation numérique directe (DNS) finement résolue d'un jet plan turbulent se développant avec le temp
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3

Alves, Portela Felipe. "Turbulence cascade in an inhomogeneous turbulent flow." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/63233.

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The inhomogeneous, anisotropic turbulence downstream of a square prism is investigated by means of direct numerical simulations (DNS) and two-point statistics. As noted by Moffatt (2002) “it now seems that the intense preoccupation [...] with the problem of homogeneous isotropic turbulence was perhaps misguided” acknowledging there is now a revived interest in studying inhomogeneous turbulence. The full description of the turbulence cascade requires a two-point analysis which re- volves around the recently derived Kármán-Howarth-Monin-Hill equation (KHMH). This equation is the inhomogeneous/
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4

Cleve, Jochen. "Data-driven theoretical modelling of the turbulent energy cascade." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2004. http://nbn-resolving.de/urn:nbn:de:swb:14-1103125565484-63361.

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Durch eine Modellierung der Energiekaskade gewinnt man wertvolle Einsichten in die Dynamik turbulenter Strömungen. In dieser Arbeit werden multiplikative Kaskadenprozesse untersucht und mit verschiedenen experimentellen Zeitreihen der Energiedissipation verglichen. Zur Berechnung der Energiedissipation ist es unvermeidlich auf eine Hilfskonstruktion zurückzugreifen, die die nicht gemessenen Komponenten des Geschwindigkeitsfeldes ersetzt. Der Schwerpunkt des Vergleichs zwischen Modell und Experiment liegt auf Zweipunktkorrelationen, weil andere Observablen, wie z. B. integrale Momente, durch di
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5

Micklow, Gerald J. "Turbomachinery cascade and wake calculation for two-dimensional compressible laminar and turbulent flow." Diss., Virginia Polytechnic Institute and State University, 1989. http://hdl.handle.net/10919/54244.

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A method is presented for the efficient analytical prediction of the two dimensional laminar or turbulent compressor or turbine cascade blade-to-blade flow field and wake. The scheme utilizes a viscous-inviscid interaction routine combining a two-dimensional full potential cascade flow solver with a two-dimensional compressible boundary layer analysis. The boundary layer analysis can compute in the direct mode with pressure gradient specified or in the inverse mode with "boundary layer mass flux" specified. When calculating with the inverse mode, flow separation can be handled easily. Turbulen
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Kishi, Tatsuro. "Scaling laws for turbulent relative dispersion in two-dimensional energy inverse-cascade turbulence." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263445.

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7

Wakefield, Bryce Edwin. "Hotwire measurements of the turbulent flow into a cascade of controlled-diffusion compressor blades." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA277297.

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8

Tang, Genglin. "Measurements of the Tip-gap Turbulent Flow Structure in a Low-speed Compressor Cascade." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/11178.

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This dissertation presents results from a thorough study of the tip-gap turbulent flow structure in a low-speed linear compressor cascade wind tunnel at Virginia Tech that includes a moving belt system to simulate the relative motion between the tip and the casing. The endwall pressure measurements and the surface oil flow visualizations were made on a stationary endwall to obtain the flow features and to determine the measurement profiles of interest. A custom-made miniature 3-orthogonal-velocity-component fiber-optic laser-Doppler velocimetry (LDV) system was used to measure all three compon
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9

Lapeyre, Guillaume. "Topologie du mélange dans un fluide turbulent géophysique." Paris 6, 2000. https://hal.archives-ouvertes.fr/tel-01475960.

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10

Togni, Riccardo. "A numerical study of turbulent Rayleigh-Bénard convection." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/6280/.

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Il flusso di Rayleigh-Bénard, costituito da un fluido racchiuso fra due pareti a diversa temperatura, rappresenta il paradigma della convezione termica. In natura e nelle applicazioni industriali, il moto convettivo avviene principalmente in regime turbolento, rivelando un fenomeno estremamente complesso. L'obiettivo principale di questo elaborato di tesi consiste nell'isolare e descrivere gli aspetti salienti di un flusso turbolento di Rayleigh-Bénard. L'analisi è applicata a dati ottenuti da tre simulazioni numeriche dirette effettuate allo stesso numero di Rayleigh (Ra=10^5) e a numeri di P
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Kahalerras, Henda. "Etude expérimentale de la profondeur de la cascade de l'intermittence." Université Joseph Fourier (Grenoble), 1997. http://www.theses.fr/1997GRE10119.

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L'evolution de l'intermittence a travers les echelles en turbulence pleinement developpe a ete mesuree par un parametre appele profondeur de la cascade de l'intermittence. L'etude experimentale a consiste a mesurer deux types d'increments de vitesse : longitudinaux et transversaux dans divers ecoulements turbulents et pour une large gamme de nombres de reynolds. L'etude des fonctions de structure a montre que le champ de vitesse n'est pas invariant d'echelle mais admet neanmoins une autosimilarite interne. Une methode des cumulants a ete utilisee pour la premiere fois afin de determiner les tr
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12

Liu, Xiaoling. "Polymeric Multicompartmentalized Systems Mimicking Artificial Cells for Controllable Multiple Enzymatic Cascade Reactions." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230515.

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Engineering artificial cells is currently an emerging area of research that involves constructing mimics of biological cells. These biomimetic cellular systems hold tremendous promise for the different biomedical applications (diagnostics, therapy, tissue engineering, gene transfection, bioactive coatings) as well as aspects of synthetic biology. A key architectural principle of the cell is a multicompartmentalized assembly, which is one of the features of biological cells that enable the performance of multiple complex biochemical reactions within confined environments. For this purpose, this
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MOLLICA, HILARIA. "Microfluidic studies for monitoring the metastatic cascade and cancer-immune cells interaction." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/999633.

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Metastases are the primary cause of death in cancer patients. Small animal models are helping dissecting some key features of the metastatic cascade but many bio-mechanic details remains difficult to analyze in vivo. For this reason a series of tools for performing systematic analysis of vascular permeability, tissue architecture, blood flow, biochemical stimuli and inflammation were produced in the last decade. Particularly relevant for this field is the use of microfluidic chips allowing to include in vitro models a vascular component. During my PhD, I applied this novel technologies to repl
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14

Castillo-Castellanos, Andrés Alonso. "Turbulent convection in Rayleigh-Bénard cells with modified boundary conditions." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066200/document.

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Une caractéristique remarquable de la convection de Rayleigh-Bénard qui concerne une couche de fluide horizontale chauffée par le bas et refroidie par le haut, est l’établissement spontané de l’ordre spatial et la formation d’une circulation cohérente à grande échelle. Comment les différents facteurs, tels que la géométrie du domaine et les conditions limites, influencent l’écoulement à grande échelle, restent une question ouverte. Malgré sa simplicité apparente, la convection de Rayleigh-Bénard présente une dynamique à grande échelle incroyablement riche et complexe, tels que des modes de tor
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15

Gao, Feng. "Advanced numerical simulation of corner separation in a linear compressor cascade." Thesis, Ecully, Ecole centrale de Lyon, 2014. http://www.theses.fr/2014ECDL0008/document.

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La demande croissante pour alléger les moteurs d’avions et diminuer les émissions polluantes de la propulsion aéronautique réclame à rendre plus compact le système de compression des moteurs, qui représente environ 40%-50% de la masse totale. Or, à taux de compression global égal, la réduction du nombre d’étage exige d’un point de vue aérodynamique une augmentation de la charge des aubes de compresseur par étage. La charge d’aube est aujourd’hui limitée car elle induit différents mécanismes de pertes tridimensionnelles très pénalisant. L’un des plus importants est le décollement de coin qui se
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Kuhl, David Derieg. "Near Wall Investigation of Three Dimensional Turbulent Boundary Layers." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/34676.

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This report documents the experimental study for four different three-dimensional turbulent flows. The investigation focuses on near wall measurements in these flows. Several experimental techniques are used in the studies; however, the bulk of the investigation focuses on a three-orthogonal-velocity-component fiber-optic laser Doppler anemometer (3D-LDA) system. The control volume of the 3D-LDA is on the order of 50 micro-meter in size, or a y<sup>+</sup> distance of around 2.3 units (using average values of U<sub>&#964</sub> and &#957; from the experiment). An auxiliary small boundary laye
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17

Ma, Wei. "Experimental investigation of corner stall in a linear compressor cascade." Phd thesis, Ecole Centrale de Lyon, 2012. http://tel.archives-ouvertes.fr/tel-00728374.

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In applied research, a lack of understanding of corner stall, i.e. the three-dimensional (3D) separation in the juncture of the endwall and blade corner region, which has limited the efficiency and the stability of compressors. Both Reynolds-averaged Navier-Stokes (RANS) and large eddy simulation (LES) still need to be calibrated for turbomachinery applications. In the fundamental research of the turbulent boundary layer (TBL), there are a lot of findings of the effects of curvature and pressure gradients, which also play an important role in physics of corner stall. The purpose of this thesis
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18

Hodge, Jacob G. "Regulation of the MEK/ERK signaling cascade by ADAM12 in triple-negative breast cancer cells." Thesis, Kansas State University, 2016. http://hdl.handle.net/2097/35228.

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Master of Science<br>Biochemistry and Molecular Biophysics Interdepartmental Program<br>Anna Zolkiewska<br>Mitogen-activated protein kinase (MAPK) signaling plays an important role in the proliferation, survival, and therapy resistance of breast cancer cells. Two important protein kinases involved in the MAPK pathway are MEK and ERK. The MEK/ERK signaling cascade can be stimulated by activation of the epidermal growth factor receptor (EGFR) upon binding of EGF-like ligands, which are released from cells by ADAM proteases. EGFR is frequently overexpressed in triple-negative breast cancer (TNBC)
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19

Andrade, João Rodrigo. "Spectral analysis of the turbulent energy cascade and the development of a novel nonlinear subgrid-scale model for large eddy simulation." Thesis, Lille 1, 2019. http://www.theses.fr/2019LIL1I006/document.

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L’objectif de cette thèse est d’analyser et d’acquérir de nouvelles connaissances sur le comportement de la dynamique de petites échelles des écoulements turbulents et de proposer un nouveau modèle sous-maille non linéaire pour la simulation des grandes échelles de la turbulence. De cette façon, la présente thèse est subdivisée en trois parties principales. Le premier sujet concerne l’analyse des incertitudes statistiques associées aux données de simulation numérique directe pour des écoulements turbulents en canal plan, fournissant une nouvelle quantification physique de ces erreurs. Dans cet
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20

Zambonini, Gherardo. "Unsteady dynamics of corner separation in a linear compressor cascade." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEC049/document.

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Le présent travail concerne l'étude du décollement de coin de compresseurs par des investigations expérimentaux sur le banc d'essai subsonique grille d'aubes situé au LMFA (Re = 3.8 x 105, M = 0,12, profil NACA 65-009). Habituellement, cette particulière séparation tridimensionnelle a lieu dans le coin entre l'aubage et la paroi du moyeu des rangées d'aubes, également dans les stators et les rotors.Les performances de l’étage sont ainsi dégradées à cause des pertes de charge et du blocage conséquent à la séparation de l’écoulement. Bien que les caractéristiques stationnaires sont bien connues
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21

Wang, Aibo. "Phosphorylation of Nur77 by MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372283/.

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22

Dunn, Timothy Alan. "The link between neuronal activity and activation of the cAMP/PKA cascade in developing retinal ganglion cells." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3311360.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed July 30, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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23

Guest, Deborah Sharon Honrado. "Modelling tumour initiating cells and their differentiation cascade, with the effects of photon irradiation and temozolomide, to optimise treatment." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599916.

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Glioblastoma murtiforme (GBM) is the most aggressive form of glioma, classified by the Wor1d Health Organisation (WHO) as a grade III or IV tumour [1]. Despite receiving a combination of radiotherapy, chemotherapy and surgical treatment, average survival is poor of 14•6 months and only a two year survival of 27•2% [2]. Present studies on cell surface markers, such as CD15, suggest that GBM is composed of a heterogeneous population of cells, derived from a brain tumour stem cell (BTSC). BTSC cells play an essential role in the growth of tumours and thus treatment therapies may be more beneficia
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Zheng, Fengyuan. "The effect of PMMA stimulated Complement-Macrophage cascade on Osteogenesis of Preosteoblast-like MC3T3-E1 cells on PMMA surface." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275497184.

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Hadjal, Yasmine. "Role de la cascade p38MAPK-p53 dans la différenciation des cellules souches embryonnaires de souris." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5031/document.

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La réussite de la thérapie cellulaire à l'aide des cellules souches embryonnaires, nécessite une bonne compréhension des mécanismes moléculaires qui contrôlent leur différenciation. Une des voies de signalisation, impliquée dans le contrôle de la différenciation des cellules souches, est la voie p38MAPK. Dans le but de comprendre les mécanismes moléculaires impliqués dans le contrôle de la différenciation précoce des cellules ES, nous avons réalisé un criblage sur puces à ADN. Les résultats du criblage ont montré que certains gènes régulés différentiellement, comme le gène Bcl2, sont des cible
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Cryar, Benjamin Joseph. "Characterisation of the up-stream components in the stretch-induced ERK-1/2 MAP kinase cascade in human myometrial cells." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9581.

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The mechanisms underlying stretch-induced signalling in the human myometrium are poorly understood. Previous work in the group has demonstrated that in vitro stretch of human myometrial cells leads to increased expression of the pro-labour factors COX-2 and IL-8 via activation of the ERK-1/2 MAPK cascade, however the identities of components upstream in this pathway have yet to be elucidated. I over expressed constitutively active Ras in human myometrial cells, leading to increased ERK-1/2 phosphorylation and elevated COX-2 and IL-8 mRNA expression. I then inhibited Ras using both the chemical
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Bear, Philip Steven. "On the Experimental Evaluation of Loss Production and Reduction in a Highly Loaded Low Pressure Turbine Cascade." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright148464084439115.

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Wildroudt, Maria L. "Characterization of the Second Messenger Signaling Cascade Linking Angiotensin II Receptor Activation with Vascular Smooth Muscle Cell Mitogenesis." Kent State University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=kent1122480402.

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29

Liu, Xiaoling [Verfasser], Brigitte [Akademischer Betreuer] [Gutachter] Voit, and Xinliang [Gutachter] Feng. "Polymeric Multicompartmentalized Systems Mimicking Artificial Cells for Controllable Multiple Enzymatic Cascade Reactions / Xiaoling Liu ; Gutachter: Brigitte Voit, Xinliang Feng ; Betreuer: Brigitte Voit." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://d-nb.info/1147287376/34.

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Liu, Xiaoling [Verfasser], Brigitte Akademischer Betreuer] [Gutachter] Voit, and Xinliang [Gutachter] [Feng. "Polymeric Multicompartmentalized Systems Mimicking Artificial Cells for Controllable Multiple Enzymatic Cascade Reactions / Xiaoling Liu ; Gutachter: Brigitte Voit, Xinliang Feng ; Betreuer: Brigitte Voit." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230515.

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Schoeberl, Birgit. "Mathematical modeling of signal transduction pathways in mammalian cells at the example of the EGF induced MAP kinase cascade and TNF receptor crosstalk." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11406710.

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Schoeberl, Birgit [Verfasser]. "Mathematical modeling of signaltransduction pathways in mammalian cells at the example of the EGF induced MAP kinase cascade and TNF receptor crosstalk / Birgit Schoeberl." Aachen : Shaker, 2004. http://d-nb.info/972377360/34.

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33

Rawal, Devika. "Use of a Neurotrophic Factor Mimetic to Block Amyloid Toxicity in Alzheimer's Disease Models." Digital WPI, 2010. https://digitalcommons.wpi.edu/etd-theses/69.

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Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world. The most accepted hypothesis for the cause of this disease is the amyloid cascade hypothesis, which postulates that the formation of extracellular neurotoxic amyloid-beta binds specific receptors on the surface of neuronal and glial cells to increase cell stress leading to cell death. Our laboratory previously showed that treatment of cultured human SHSY neuronal cells with amyloid beta increases the cellular levels of two key components (caspases-2 and -3) of the extrinsic apoptotic pathway, leading to ce
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Sato, Masaaki. "NMDA receptor stimulation and brain-derived neurotrophic factor up-regulate Homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells." Kyoto University, 2001. http://hdl.handle.net/2433/150166.

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Gupta, Nishith. "An Intimate Dining – Nutritional Interactions between Obligate Intracellular Parasites and Host Cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/18657.

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Das zu den Protozoen gehörende Phylum der Apicomplexa umfasst nahezu 6000 Parasitenarten. Die meisten Apicomplexa haben sich an eine obligat intrazelluläre Lebensweise angepasst und infizieren verschiedenste Tiere und den Menschen. Zu den bedeutendsten Vertretern der Apicomplexa zählen Toxoplasma, Plasmodium und Eimeria. In dieser Arbeit lag der Schwerpunkt auf den drei repräsentativen Organismen Toxoplasma gondii, Eimeria falciformis und Plasmodium berghei, welche sich alle in einem etablierten Wirt (der Maus) reproduzieren, sich allerdings hinsichtlich ihrer Wirtszellen, Persistenz sowie in
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Conway, Ann Marie. "Growth factor receptor tyrosine kinase-, G-protein coupled receptor- and sphingolipid-dependent regulation of the extracellular signal-regulated kinase cascade in cultured airway smooth muscle cells." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366970.

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BERETTA, FRANCESCA. "GluR2 subunit inhibits tumor proliferation via inactivation of src-erk1/2 cascade and induces apoptosis through a caspase 3/6 dependent-activation in glioblastoma multiforme cells." Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/63227.

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梁靜茹 and Ching-yu Leung. "Interactions of pacap and dopamine in regulating growth hormone release from grass carp pituitary cells: functional role of the camp - dependent cascade and ca2+ entrythrough voltage-sensitive ca2+ channels." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31221312.

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Leung, Ching-yu. "Interactions of pacap and dopamine in regulating growth hormone release from grass carp pituitary cells : functional role of the camp - dependent cascade and ca2+ entry through voltage-sensitive ca2+ channels /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20793200.

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Ovsyannikov, Mikhail [Verfasser], Jörg [Akademischer Betreuer] Schumacher, Christian [Gutachter] Karcher, and Olga [Gutachter] Shishkina. "Numerical studies of turbulent Rayleigh-Bénard convection in closed cells : boundary layer dynamics and large scale patterns / Mikhail Ovsyannikov ; Gutachter: Christian Karcher, Olga Shishkina ; Betreuer: Jörg Schumacher." Ilmenau : TU Ilmenau, 2018. http://d-nb.info/1178125254/34.

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Than, Trong Emmanuel. "Le rôle de la signalisation Notch3 dans le maintien des cellules souches neurales du télencéphale adulte Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signaling cascade in the vertebrate adult brain her4-expressing neural stem cells are maintained through population asymmetry and embedded into a hierarchy of progenitors responsible for their life-long expansion Radial Glia and Neural Progenitors in the Adult Zebrafish Central Nervous System." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS541.

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Un certain nombre de régions du cerveau des vertébrés, y compris chez l’homme, continuent d’être le siège de l’ajout de nouveaux neurones à l’âge adulte. Ces nouveaux neurones sont produits à partir de cellules spécialisées, appelées cellules souches neurales (CSN). Celles-ci sont capables de s’auto-renouveler et sont principalement trouvées dans un état d’arrêt transitoire du cycle cellulaire que l’on appelle quiescence. A l’heure actuelle, les mécanismes cellulaires et moléculaires permettant aux CSN de trouver un équilibre entre maintien et différentiation, ainsi que les règles générales go
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Disotell, Kevin James. "Low-Frequency Flow Oscillations on Stalled Wings Exhibiting Cellular Separation Topology." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449162356.

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Herberg, Maria, Tüzer Kalkan, Ingmar Glauche, Austin Smith, and Ingo Roeder. "A Model-Based Analysis of Culture-Dependent Phenotypes of mESCs." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-147356.

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Mouse embryonic stem cells (mESCs) can be maintained in a proliferative and undifferentiated state over many passages (self-renewal) while retaining the potential to give rise to every cell type of the organism (pluripotency). Autocrine FGF4/Erk signalling has been identified as a major stimulus for fate decisions and lineage commitment in these cells. Recent findings on serum-free culture conditions with specific inhibitors (known as 2i) demonstrate that the inhibition of this pathway reduces transcription factor heterogeneity and is vital to maintain ground state pluripotency of mESCs. We su
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HANNA, REEM. "ELECTROMAGNETIC MODELING FOR THE DEVELOPMENT AND OPTIMIZATION OF DIFFERENT DEVICES TO SUPPORT BONE REGENERATION." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1002772.

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Tissue healing is in general a complex process, which involves both local and systemic responses, and bone regeneration in particular is much slower than repair in any other human tissue. Thus, it exhibits a great challenge in clinical practice and in the field of research. Bone regeneration is comprised of a series of biological events, involving a number of cell types and intracellular and extracellular molecular- signaling pathways, with a definable temporal and spatial sequence, in an effort to optimize the skeletal repair and restore its functionality. Photobiomodulation (PBM) therapy ha
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Cleve, Jochen [Verfasser]. "Data-driven theoretical modelling of the turbulent energy cascade / vorgelegt von Jochen Cleve." 2004. http://d-nb.info/974154792/34.

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Ho, Tzung-Han, and 何宗翰. "Cascade Organic Solar Cells with Two Exciton Dissociation Surfaces." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/84205332698733790633.

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碩士<br>臺灣大學<br>物理研究所<br>98<br>Due to the abuse of fossil fuel, there have been a lot of carbon dioxide exhausted into the air.The carbon dioxide will cause climate change and the temperature of earth to rise,which further result in many disasters in the world. To solve this problem, the research of renewable energy become more and more important, especially the development of solar cells.Organic solar cells had been developed quickly since 1986, the efficiency now is about 7%. The improvement of organic solar cells is divided into two regions, one is the synthesis of new materials,the other is
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ju, Hsieh ya, and 謝雅如. "Signaling cascade in photodynamic therapy triggered death of human epidermoid carcinoma A431 cells." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/88242295376158861128.

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碩士<br>長庚大學<br>基礎醫學研究所<br>89<br>Photodynamic therapy (PDT) is one kind of photochemo-therapeutic treatment. It had been approved by FDA for treatment of some tumor. When cells uptake photosensitizers and exposed to specific wavelength of light, the photosensitizers can absorb the energy from photon and then transfer the energy to oxygen molecule to form reactive oxygen species (ROS), which can then induce cell death by intracellular signal transduction. Previous work from this laboratory had dissected the apoptotic signal pathway in human epidermal carcinoma A431 cell treated with PDT using Ros
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Ming-Chang and 謝明璋. "Antizyme induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases’ cascade." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/92436048107887339418.

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碩士<br>中山醫學大學<br>免疫學研究所<br>94<br>Antizymes delicately regulate ornithine decarboxylase (ODC) enzyme activity and polyamine transport. One member of the family, antizyme-1, plays the vital roles in molecular and cellular functions, including developmental regulation, cell cycle, proliferation, cell death, differentiation and tumorigenesis. However, how does it participate in the cell apoptotic mechanism is still unidentified. To elucidate the contribution of human antizyme-1 in haematopoietic cell death, we examine whether inducible overexpression of antizyme enhances the apoptotic cell death. A
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Huang, Shih-Che, and 黃士哲. "Sensitization of Nanocrystalline TiO2 Solar Cells by Using Organic Dye Cocktails and Bandgap Cascade Approaches." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/12281478064650526764.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>95<br>Although dye-sensitized solar cells (DSSCs) with ruthenium (Ru) complexes as sensitizers may reach an overall efficiency up to 11%, the limited availability of Ru complexes will become a problem if DSSCs find wide application. Compared with Ru complexes, organic sensitizer dyes which generally have much larger molar extinction coefficients and can be prepared and purified more easily and economically, therefore, exhibit promising potential in DSSC applications. Organic dyes, however, have relatively sharp absorption bands in the visible region, which is a di
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Wang, Aibo. "Phosphorylation of Nur77 by MEL-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells." 2009. https://scholarworks.umass.edu/dissertations/AAI3372283.

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Nur77, an orphan nuclear receptor, plays a key role in T cell apoptosis. As a transcription factor, Nur77 is assumed to exert its functions by driving the expression of target genes. However, Nur77 targets in T cell apoptosis are unknown. In cancer cell lines, Nur77 can induce apoptosis through the intrinsic apoptotic pathway but it remains controversial how Nur77 kills T cells. In this study, we provide biochemical, pharmacological and genetic evidence demonstrating that Nur77 induces apoptosis through the activation of the intrinsic pathway in T cells. We also show that Nur77 is a physiologi
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