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Dissertations / Theses on the topic 'Cascade reaction'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Rimmington, Stuart. "A radical cascade reaction approach towards Taxol." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479330.

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2

Kinnell, Angela Dawn. "Development of an organo-and enzyme-catalysed cascade reaction." Thesis, University of Leeds, 2010. http://etheses.whiterose.ac.uk/1132/.

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This thesis describes the development of a novel one-pot reaction (Scheme 1). The reaction combines organo- and enzyme-catalysis in an aldol/aldol cascade for the first time. The bicatalytic, three-component assembly involves two aldol reactions: an organocatalysed reaction and an aldol reaction catalysed by an aldolase. The feasibility of the one-pot reaction was evaluated by testing whether the aldol intermediates 3 were substrates for the E192N aldolase variant of Nacetylneuraminic acid lyase. A range of compounds was selected as potential substrates for the enzyme. The synthesis of the com

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3

Poon, Hon-suen. "Michael initiated cascade reaction sequences and their application in target synthesis." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246237.

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4

Marcotte, Joel. "Formal Synthesis of (+/-) Morphine via an Oxy-cope/Claisen/Ene Reaction Cascade." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23560.

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For years now, opium alkaloids and morphinans have been attractive synthetic targets for numerous organic chemists due to their important biological activity and interesting molecular architecture. Morphine is one of the most potent analgesic drugs used to alleviate severe pain. Our research group maintains a longstanding interest in tandem pericyclic reactions such as the oxy-Cope/Claisen/ene reaction cascade and their application to the total synthesis of complex natural products. Herein we report the ventures towards the formal synthesis of (+/-)-morphine based on the novel tandem oxy- Cope

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5

Naoe, Saori. "Synthesis of Fused-Ring Compounds through Gold-Catalyzed Cascade Reactions." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215495.

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6

Shah, Parin Ajay. "Synthesis of terpenoids using a tandem cationic cascade cyclization-electrophilic aromatic substitution reaction." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6639.

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The terpene and terpenoid family of compounds is considered to be the largest group of natural products. These compounds not only display great diversity in their structural features but are also known to have a multitude of biological activities including but not limited to anti-bacterial, anti-cancer, anti-inflammatory, and anti-HIV properties. Remarkably, all the terpenoids formed in nature come from two molecules viz. isopentenyl pyrophosphate and its isomer, dimethylallyl pyrophosphate both consisting of just five carbons but assembled in many ways. Nature utilizes highly efficient, enzym

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7

LIN, PENG. "Enzyme cascade reactions on 3D DNA scaffold with dynamic shape transformation." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265209.

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京都大学<br>新制・課程博士<br>博士(エネルギー科学)<br>甲第23437号<br>エネ博第424号<br>新制||エネ||81(附属図書館)<br>京都大学大学院エネルギー科学研究科エネルギー基礎科学専攻<br>(主査)教授森井孝, 教授佐川尚, 教授片平正人<br>学位規則第4条第1項該当<br>Doctor of Energy Science<br>Kyoto University<br>DFAM

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8

Belletti, Giada. "Organocatalytic Enantioselective Vinylogous Aldol-Lactonization Cascade Reaction of 3-Alkylidene Oxindoles to Trifluoromethyl Ketones." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14463/.

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In this work, an highly enantioselective vinylogous aldol-lactonization cascade reaction of 3-alkylidene oxindole to α,β-unsaturated trifluoromethyl ketone, promoted by bifunctional organocatalysts, is presented. The reaction proceed through 1,2-addition followed by cascade lactonization to afford an unsaturated lactone bearing a chiral trifluoromethylated tetrasubstituted carbon stereocenter with high enantioselectivity and moderate yield. Nevertheless, also the two E/Z isomers of the correspondent 1,2-addition product are obtained.

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9

Pelletier, Sophie Marie-Clémentine. "One-pot nitro-Mannich cascade reactions : new methodologies and synthetic applications." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:283641bf-bb4e-48a8-8a28-2e048b8c4ea6.

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Pyrrolidine and pyrrolidinone rings are common motifs found in many biologically active natural products and drugs. Accordingly, our work focuses on the development of new methodologies for their one-pot synthesis. An efficient diastereoselective nitro-Mannich / lactamisation reaction cascade of methyl 3-nitropropanoate with cyclic and acyclic imines for the direct preparation of trans-monocyclic and fused tricyclic pyrrolidinone derivatives was developed. The reaction is easy to perform, broad in scope and tolerates a wide variety of functional groups. For the monocyclic methodology, 28 examp

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10

Zhu, Koudi. "Model Studies Towards the Total Synthesis of Lyconadin A via An Acyl Radical Cascade Reaction." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1364.pdf.

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11

Paris, Juraj [Verfasser]. "Combination of Suzuki cross-coupling reaction and biocatalysis in one-pot cascade processes / Juraj Paris." Bielefeld : Universitätsbibliothek Bielefeld, 2019. http://d-nb.info/1206592222/34.

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12

Tokimizu, Yusuke. "Synthesis of Heterocyclic Scaffolds through Transition-Metal-CatalyzedCascade Reactions of Alkynes." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199500.

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13

Iwata, Akira. "Development of Novel Methods for Synthesis of Fused Indole-Type Compounds." Kyoto University, 2018. http://hdl.handle.net/2433/232328.

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14

CATERINA, RISI. "Studies on organic synthesis through sustainable catalysis." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1094721.

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Today the development of sustainable processes in the chemical industry is critical, and Green Chemistry represents an evolution from the conventional concepts of process efficiency. Twenty years ago, Paul Anastas and John Warner introduced this concept within the twelve principles. In this work, many aspects the twelve principles are applied, developing sustainable methods involving the use of metal catalysis and biocatalysis through one pot and cascade reactions.<br>In the first part of the PhD period, the use of the micellar catalysis was investigated, to perform reactions in water avoiding

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15

Charpenay, Mélanie. "Fenestradiènes et cyclooctatriènes : synthèse directe par réaction en cascade palladocatalysée." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00836869.

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Ces travaux de thèse nous ont permis de mettre au point différentes voies de synthèse de systèmes polycycliques complexes tels que des fenestradiènes et des cyclooctatriènes, par réactions en cascades palladocatalysées. Celles-ci débutent par une réaction de cyclocarbopalladation 4-exo-dig et est suivie par un couplage de Sonogashira. Dans des conditions adéquates, une réaction d'addition d'alcyne sur une triple liaison a ensuite lieu et [permet] d'accéder à un intermédiaire de type tétraène, dont les quatre doubles liaisons conjuguées permettent au système de subir spontanément une électrocyc

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16

Walker, Richard James. "Quantum cascade laser spectroscopy : developments and applications." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:5021ac50-c69d-4a1d-8071-e59ffed9fcb8.

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This thesis presents work examining the characteristics and applicability of quantum cascade lasers. An introduction is given explaining both the desire for a widely tunable, narrow bandwidth device working in the midinfrared, as well as detailing the ways in which quantum cascade lasers (QCLs) fulfill these requirements. The development and manufacture of QCLs are then discussed. The experimental section of this thesis is then split into three parts. Chapter 2 concerns the characterisation and application of several pulsed QCLs. The intrapulse mode of operation is employed and the effect of t

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17

Matsuoka, Junpei. "Total Synthesis of Indole Alkaloids Based on Direct Construction of Pyrrolocarbazaole Scaffolds via Gold-Catalyzed Cascade Cyclizations." Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/253241.

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京都大学<br>0048<br>新制・課程博士<br>博士(薬学)<br>甲第22405号<br>薬博第843号<br>新制||薬||241(附属図書館)<br>京都大学大学院薬学研究科薬学専攻<br>(主査)教授大野浩章, 教授高須清誠, 教授竹本佳司<br>学位規則第4条第1項該当<br>Doctor of Pharmaceutical Sciences<br>Kyoto University<br>DFAM

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18

Gao, Ming. "Ketone synthesis via rhodium-catalyzed traceless chelation-controlled hydroacylation reactions." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:487b65f9-d1f7-4fee-b2bb-358837866ca2.

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This thesis documents the development of rhodium-catalyzed traceless chelation-controlled hydroacylation reactions for the synthesis of a variety of ketone products. <strong>Chapter 1</strong> provides an overview of rhodium-catalyzed hydroacylation chemistry, focusing on the origin of chelation-controlled strategies and the benefits thereof. <strong>Chapter 2</strong> describes a sequential reaction involving alkene hydroacylation, sulfide elimination and boronic acid conjugate addition, which affords products with the initial sulfide coordinating group replaced by a stereochemically defined

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19

François, Benjamin. "Utilisation d’organoboranes fonctionnalisés pour la construction de structures polycycliques." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1S114.

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Les composés organoborés constituent des outils remarquables en synthèse organique de par leur chimie très diversifiée. Les travaux présentés dans ce mémoire abordent de nouveaux aspects de leur réactivité. Une méthode de synthèse rapide et efficace de 9-hydroxyfluorènes est décrite via une séquence tandem Suzuki/ aldolisation phénolique. Ce processus a été ensuite étendu aux 9-aminofluorènes en ajoutant simplement comme troisième partenaire diverses amines au milieu réactionnel. Des hypothèses mécanistiques sont proposées pour rationaliser ces résultats expérimentaux. Dans une deuxième partie

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20

Colin, Olivier. "Plateforme pyridylalkylamine modulable : un outil pour la catalyse." Thesis, Versailles-St Quentin en Yvelines, 2015. http://www.theses.fr/2015VERS023V/document.

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Les travaux exposés dans ce manuscrit s’articulent autour de l’élaboration de nouvelles plateformes pyridylalkylamines polyfonctionelles et chirales afin de permettre le développement d’un nouveau processus de réactions catalysées en cascade. La première partie de ce document décrit la synthèse de plateformes pyridylméthylamines (pma) portant des motifs chiraux et (thio)urées. La seconde partie traite de leur utilisation dans des réactions d’organocatalyse et de métallocatalyse asymétriques, puis dans des réactions catalysées en cascade séquencée. La troisième partie porte sur la synthèse de p

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21

Cassani, Carlo. "Aminocatalytic functionalization of carbonyl compounds: a powerful strategy for enantioselective reaction development." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/129286.

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En esta tesis se mostra como la aminocatalisis pueda ser utilizada para resolver importantes problemas en sintesis organica. En el primer proyecto tres reacciones en cascada aminocatalizadas han sido optimizadas para la síntesis de productos spiro-cíclicos derivados de las benzofuranonas. Estas moléculas, que tienen un esqueleto presente también en muchos productos naturales, han sido sintetizadas como un sólo enantiomero gracias al uso de amina primaria y secondaria. Un segundo proyecto muestra la primera activación aminocatalizada de cetonas α-substituidas α,β-insaturadasen el ámbito de una

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22

Colonna, Pierre. "Un cyclopropane donneur-accepteur original pour la synthèse de benzocylobutènes substitués via une cascade réactionnelle." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0336.

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Les dérivés BenzoCycloButènes (BCBs) constituent une classe unique de molécules correspondant au greffage d’un cycle carboné à 4 chaînons sur un motif aromatique. L’effet coopératif entre la stabilité thermodynamique du noyau aromatique d’une part et la grande réactivité du cycle tendu d’autre part en font une brique moléculaire original ayant diverses applications telle que le développement de polymères. En parallèle, les cyclopropanes sont des molécules hautement valorisables car il s’agit d’éléments permettant d’atteindre une grande complexité moléculaire dans une démarche à économie d’atom

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23

Selmani, Aymane. "Réactions en cascade catalysées par le rhodium : nouvelles voies d'accès à des carbocycles et hétérocycles chiraux." Thesis, Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2019SORUS372.pdf.

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Ce manuscrit présente le développement de nouvelles réactions énantiosélectives d’insertion-carbocyclisation en cascade, catalysées par le rhodium(I) et initiées par les acides boroniques, pour la formation d’hétéro- et de carbocycles chiraux fonctionnalisés. Pour ces transformations asymétriques, les diènes chiraux, notamment les ligands Ar-MSBod, sont les plus adaptés et permettent d’atteindre des énantiosélectivités élevées, ce qui a conduit à la conception d’une voie alternative de synthèse de ces diènes monosubstitués. Les premiers travaux ont porté sur la préparation de cycles à cinq cha

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24

Simon, Ingrid. "Indolo[2,3-b]quinoléines : cascade radicalaire combinant une cyclisation 5-exo-trig avec le réarrangement de Smiles." Thesis, Reims, 2013. http://www.theses.fr/2013REIMP203/document.

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Le squelette indolo[2,3-b]quinoléique est une cible synthétique attrayante car il est présent notamment dans la néocryptolépine, alcaloïde aux propriétés cytotoxiques et antipaludéennes. Nous proposons ici une approche originale pour accéder à ce tétracycle, qui combine dans une réaction radicalaire en cascade une cyclisation à un réarrangement de Smiles. La mise au point des conditions expérimentales et l'étude mécanistique de cette voie ont constitué le premier objectif de ce travail. Outre les produits attendus, les études structurales approfondies ont mis en évidence la formation de compos

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25

Dandach, Amar. "Transformation de la cellulose en bioproduits : une approche intégrée couplant la catalyse enzymatique et la catalyse hétérogène." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1129.

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Ces travaux de thèse portent sur la possibilité de combiner la catalyse hétérogène et la catalyse enzymatique dans une réaction en cascade de transformation de la cellulose en produits d’intérêt. Le prétraitement enzymatique (Celluclast, un cocktail de cellulases) a été choisi comme première étape de transformation de la cellulose en vue de la fragiliser; elle est réalisée dans une solution tampon d’acide acétique et d’acétate de sodium à pH 4,75, à 50°C. Cette étape produit principalement du glucose et modifie structurellement la cellulose résiduelle en diminuant seulement son degré de polymé

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26

Ensari, Yunus Verfasser], Ulrich [Akademischer Betreuer] [Schwaneberg, and Marco [Akademischer Betreuer] Oldiges. "Synthesis of oxo-fatty acid esters in a whole cell cascade reaction with engineered monooxygenase (P450 BM3) and dehydrogenase (cpADH5) variants / Yunus Ensari ; Ulrich Schwaneberg, Marco Oldiges." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/116327609X/34.

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27

Ensari, Yunus [Verfasser], Ulrich [Akademischer Betreuer] Schwaneberg, and Marco [Akademischer Betreuer] Oldiges. "Synthesis of oxo-fatty acid esters in a whole cell cascade reaction with engineered monooxygenase (P450 BM3) and dehydrogenase (cpADH5) variants / Yunus Ensari ; Ulrich Schwaneberg, Marco Oldiges." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/116327609X/34.

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28

Johannsen, Jens Peter [Verfasser]. "Towards Bridging the Gap between Academia and Industrial Application of Enzyme-Based Processes : A Multi-Enzyme Cascade Reaction in a Miniplant Two-Phase System / Jens Peter Johannsen." Düren : Shaker, 2021. http://d-nb.info/1240583966/34.

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29

Liu, Jian. "Application of squarate ester cascade reactions to the synthesis of (+/- ) hypnophilin. New photorearrangements of 2-Cyclopentenones. Studies towards the total synthesis of pectenotoxin II." Columbus, Ohio : Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1037679001.

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Thesis (Ph. D.)--Ohio State University, 2002.<br>Title from first page of PDF file. Document formatted into pages; contains xiv, 242 p.). Includes abstract and vita. Advisor: Leo A. Paquette, Dept. of Chemistry. Includes bibliographical references (p. 233-242).

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30

Dumrongchai, Nuethip. "Palladium Catalyzed Multicomponent Cascade Reactions." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487516.

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This Thesis is divided into three parts: Introduction (Chapter 1), Result and Discussion (Chapter 2) and Experimental (Chapter 3). The Introduction (Chapter 1) provides a review of the recent literature relating to the 1,3dipolar cycloaddition reactions. ItÃ‚Â· covers nitrones, azomethine ylides and azomethine imines. The Result and Discussion. section (Chapter 2) deals with the author's work which is . concerned with developing four novel multicomponent cascade reactions. These are (i) a 3- component cascade involving bifunctional aryl halide! Michael acceptors, allene and arriine or sulphona

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31

Buquoi, John Q. III. "Multicomponent Radical Reactions Incorporating Heteroatom-Carbon Bonds Via Polarity-Reversal Cascades." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574348050305556.

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32

Massolo, E. "NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/330262.

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The objective of this PhD study was to apply organocatalytic synthetic methods for the regio- and stereoselective synthesis of highly functionalized compounds. We exploited different organocatalytic activation modes to peculiar substrates we identified as suitable building blocks for versatile products in enantiomerically enriched form. In particular the developed projects relied on stereoselective amino- and hydrogen bonding organocatalysis, employing beta-nitroacrylates, beta-trifluoromethylated nitroalkenes and 2,2,2-trifluoroethyl 2-[(1,3-dithian)-2-yl]-ethanthioate in combination with var

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33

Pocock, Ian. "Novel cascade aryne-capture/rearrangement reactions." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/23743/.

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Arynes are reactive intermediates that have been an academic curiosity for over a century. A recent renaissance of interest in the chemistry of these intermediates can be traced back to the development of ortho-(silyl)aryl triflates as aryne precursors. The application of aryne chemistry outside academia has been precluded by the expense and laborious preparation of these precursors. Diphenyliodonium-2-carboxylate has been shown to be a stable and inexpensive benzyne precursor, however application has been limited due to the high temperature (>160 ºC) and long reaction times required to genera

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34

Demircan, Aydin. "Cascade reactions involving a furan core." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297561.

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Amjad, Ê¿AliÌ„. "Cobalt-mediated cascade cyclisation reactions in synthesis." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357981.

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Too, Heng Kwee Marie Kathleen Sien Kiow. "Glycomimetics and peptidomimetics via catalytic cascade reactions." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405741.

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Annis, Michael Colin. "Free radical cascade reactions involving furan rings." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394991.

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Yap, Aaron J. "Hydrogenolysis, hydrogenation and nanoencapsulation in cascade reactions." Thesis, The University of Sydney, 2012. https://hdl.handle.net/2123/29153.

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Catalytic nanoreactors, prepared by the Layer-by-Layer encapsulation of zeolite H-Beta, were used in the dynamic kinetic resolution (DKR) of 1-phenylethanol and 1-indanol. Yields for both alcohols were clearly above 50%, with ee’s over 85%, indicating successful protection of the pH-sensitive enzyme, candida antarctica lipase B, from the acidic zeolite. Attention proceeded to the DKR of amines, which can involve the undesired hydrogenolysis reaction during the racemisation step. Thus, the phenomenon of hydrogenolysis was investigated. The hydrogenolysis of various amines, imines, and

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39

Boudhar, Aicha. "Fenestranes, cyclooctatriènes et leurs dérivés comme châssis moléculaires innovants pour le développement de plateformes modulables." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00855441.

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Ces travaux de thèse nous ont permis de mettre en évidence un accès à un large nombre de composés polycycliques. Les étendues des méthodes employant des cascades réactionnelles palladocatalysées et leurs limites ont été étudiées. L'initialisation de ces cascades se fait par une cyclocarbopalladation de type de 4-exo-dig, suivie par un couplage de Sonogashira. Avec des substrats et des conditions adéquats, la cascade réactionnelle continue avec une alcynilation, une électrocyclisation à huit électrons p et une électrocyclisation à six électrons p. En un nombre limité d'étapes sont ainsi obtenus

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40

Double, Philip John. "Acyl radical cascade reactions : the synthesis of azasteroids." Thesis, University of Nottingham, 1998. http://eprints.nottingham.ac.uk/27769/.

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Our work has been concerned with the synthesis of azasteroid ring systems, utilising acyl radical cascade reactions. Chapter 1 comprises an overview of published work relevant to our studies: an analysis of steroid biosynthesis and synthesis; a review of the use of azasteroids, their biological activity and current synthetic techniques in azasteroid formation. This initial chapter also includes an introduction to published work in the area of nitrogen heterocycle synthesis using radical reactions and finally the use of acyl radicals in synthesis, particularly cascade reactions. Chapter 2 start

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41

Chaudhry, Sofia Javid. "Application of statistics and robotics to cascade reactions." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551229.

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My thesis is composed of four themed sections: (1) The introduction reviews the Prins reaction, focusing mainly on the Prins condensation-cyclisation of homoallylic alcohols with aldehydes giving substituted tetrahydropyrans. This section also briefly reviews the Prins reaction giving dihydropyrans and the aza-Prins reaction giving piperidines and dihydropiperidines. (2) The results and discussion section details the author's own work and is further divided into two parts. The first part describes the synthesis of novel homoallylic alcohols and bis-homoallylic alcohols from Pd(O)/ln(O) mediate

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42

Boehm, Haydn M. "Tandem radical cascade cyclisation reactions in steroid synthesis." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364673.

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43

Reviriot, Yasmin. "Combinaisons d'organocascades énantiosélectives avec des superacides : études mécanistiques et nouvelles opportunités synthétiques pour l'accès aux hétérocycles de taille moyenne." Electronic Thesis or Diss., Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0527.

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Les hétérocycles azotés de taille moyenne sont une classe de composés très importante puisqu’ils sont largement présents dans les substances biologiquement actives naturelles ou synthétiques. Les travaux présentés ici consistent en l’élaboration de méthodologies originales grâce à l’utilisation d’outils puissants de la chimie organique que sont les « Multiple Bond-Forming Transformations » (MBFT’s), l’organocatalyse énantiosélective et l’activation en milieu superacide. Cette association synergique à ouvert de nouvelles opportunités synthétiques pour l’élaboration sélective de nouveaux hétéroc

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Heffernan, Stephen John. "The development of novel gold-catalysed indole cascade reactions." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557812.

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Divided into three distinct research areas, this thesis investigates the synthetic utility of enynones and ynamides towards the formation of biologically relevant structures. The first volume of work (Chapter 2) describes the gold-catalysed double alkylation of indole by enynones. The [6,5,7]-tricycles formed in this reaction are generally provided in excellent yield with complete regioselectivity. Optimisation of the procedure, a thorough substrate investigation, and mechanistic insights are discussed within. The gold-catalysed rearrangement of ynamido esters is described in Chapter 3. Follow

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Qureshi, Ashfaq M. "A study of the cascade photochemical reactions of substituted maleimides." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443665.

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Capaccio, Vito. "Enantioselective construction of new heterocyclic scaffolds via organocatalyzed cascade reactions." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4253.

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2017 - 2018<br>Chirality plays a vital role in human daily life. After the famous but tragic case regarding the Thalidomide, Food and Drug Administration (FDA) gave a guide in relation to the submission of new drug applications... [edited by Author]<br>XXXI ciclo

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LURIDIANA, ALBERTO. "Synthesis of high-value small molecules through new cascade reactions." Doctoral thesis, Università degli Studi di Cagliari, 2021. http://hdl.handle.net/11584/314052.

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Providing non-traditional disconnections has been recently highlighted as one of the “Key messages for organic chemistry when it comes from drug discovery” by scientists from GSK, Pfizer, and AstraZeneca. Apart from the possibility to unlock the access to previously unattainable chemical matter, the establishment of a novel synthetic approach could furnish new solutions in terms of cost, safety, eco-sustainability and time-consuming of a synthetic process. In the realm of ideal synthesis, cascade reactions are well known for their efficiency in building up molecular complexity starting from si

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Gregory, Alexander William. "Cyclisation cascades via reactive iminium intermediates." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8e633fee-3457-4c31-939c-4421fac2fb8f.

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The aim of this D.Phil was to develop a range of cyclisation cascades, which initially form a reactive iminium intermediates that can then be attacked by a pendant nucleophile resulting in novel polycyclic structures. This concept has been applied to the development of three methodologies and has resulted in the discovery of new reactivity as well as the synthesis of a wide range of interesting novel structures <b>Chapter 1: Enantioselective chiral-BINOL-phosphoric acid catalysed reaction cascade</b> A highly enantioselective hydroamination / N-sulfonyliminium cyclisation cascade using a combi

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Ross, Adam. "Novel routes to, and reactions of, cyclopropanes." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/16315.

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An array of different cyclopropanes have been synthesised, including the structurally simple 1-phenylcyclopropanol. These were synthesised in yields upwards of 60%, using the well published Kulinkovich reaction. From 1-phenylcyclopropanol, variations of the cyclopropane core structure were synthesised, creating species ideal for palladium cross coupling reactions, such as 1-phenylcyclopropyl methanesulfonate and 1-phenylcyclopropyl 4-methylbenzenesulfonate. These were formed in 50 and 60% yield respectively. Once obtained these cyclopropanes were used to perform Suzuki cross coupling reactions

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Banert, Klaus, Sandra Bochmann, Andreas Ihle, et al. "Synthesis with Perfect Atom Economy: Generation of Furan Derivatives by 1,3-Dipolar Cycloaddition of Acetylenedicarboxylates at Cyclooctynes." Universitätsbibliothek Chemnitz, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-152891.

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Cyclooctyne and cycloocten-5-yne undergo, at room temperature, a 1,3-dipolar cycloaddition with dialkyl acetylenedicarboxylates 1a,b to generate furan-derived short-lived intermediates 2, which can be trapped by two additional equivalents of 1a,b or alternatively by methanol, phenol, water or aldehydes to yield polycyclic products 3b–d, orthoesters 4a–c, ketones 5 or epoxides 6a,b, respectively. Treatment of bis(trimethylsilyl) acetylenedicarboxylate (1c) with cyclooctyne leads to the ketone 7 via retro-Brook rearrangement of the dipolar intermediate 2c. In all cases, the products are formed w

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