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Relevant bibliographies by topics / Caspases – physiology

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Academic literature on the topic 'Caspases – physiology'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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Journal articles on the topic "Caspases – physiology"

1

Zhuang, Shougang, and Gabriel Simon. "Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells." American Journal of Physiology-Cell Physiology 279, no. 2 (2000): C341—C351. http://dx.doi.org/10.1152/ajpcell.2000.279.2.c341.

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In this study, we show that caspases 2, 3, 6, and 7 were activated during peroxynitrite-induced apoptosis in human leukemia HL-60 cells and that processing of these caspases was accompanied by cleavage of poly(ADP-ribose) polymerase and lamin B. Treatment of cells with DEVD-fluoromethyl ketone (FMK), a selective inhibitor for caspase 3-like proteases, resulted in a marked diminution of apoptotic cells. VAVAD-FMK, an inhibitor of caspase 2, partially inhibited the apoptotic response to peroxynitrite. However, selective inactivation of caspase 6 by VEID-FMK did not affect apoptosis rates. These

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Jones, Blake, Patricia J. Roberts, William A. Faubion, Eiki Kominami, and Gregory J. Gores. "Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line." American Journal of Physiology-Gastrointestinal and Liver Physiology 275, no. 4 (1998): G723—G730. http://dx.doi.org/10.1152/ajpgi.1998.275.4.g723.

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We have previously demonstrated abrogation of bile salt-induced apoptosis by cathepsin B inhibitors. However, caspases have been strongly implicated in apoptosis, and the mechanistic interface between caspase and cathepsin B activation is unclear. Thus our aims were to determine the mechanistic relationship between caspases and cathepsin B in bile salt-induced apoptosis in a rat hepatoma cell line. Expression of cystatin A was used to inhibit cathepsin B, whereas Z-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK) was used to inhibit caspases. Cystatin A expression prevented cathepsin B activation a

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Peluffo, Marina C., Richard L. Stouffer, and Marta Tesone. "Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum." American Journal of Physiology-Endocrinology and Metabolism 293, no. 5 (2007): E1215—E1223. http://dx.doi.org/10.1152/ajpendo.00261.2007.

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Studies were designed to examine the expression and activity of four caspases that contribute to the initial (caspases-2, -8, and -9) and final (caspase-3) events in apoptosis in the rat corpus luteum (CL) during pregnancy ( days 7, 17, 19, and 21 of gestation), postpartum ( days 1 and 4), and after injection (0, 8, 16, 24, and 36 h) of the physiological luteolysin PGF2α. In addition, the temporal relationship of caspase expression/activity relative to steroid production and luteal regression was evaluated. During pregnancy, the activity of all four caspases was significantly greater on day 19

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Grossmann, Johannes, Susanne Mohr, Eduardo G. Lapetina, Claudio Fiocchi, and Alan D. Levine. "Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 274, no. 6 (1998): G1117—G1124. http://dx.doi.org/10.1152/ajpgi.1998.274.6.g1117.

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Detachment-induced cell death (DICD) is considered to be one of the means by which intestinal epithelial cells (IEC) die of apoptosis as they reach the lumen and are shed. Caspases, a family of cysteine proteases, play a central role in initiating, amplifying, and executing apoptosis; however, the pattern of caspase activation in response to distinct apoptotic stimuli remains unknown. We investigated the kinetics of caspase activation during DICD in freshly isolated human IEC. DNA fragmentation is observed 90 min after detachment and is preceded by the sequential activation of preformed member

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Kaushal, Gur P., Amar B. Singh, and Sudhir V. Shah. "Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury." American Journal of Physiology-Renal Physiology 274, no. 3 (1998): F587—F595. http://dx.doi.org/10.1152/ajprenal.1998.274.3.f587.

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In the present study, we demonstrate that rat kidney contains caspase activity that was markedly inhibited by specific peptide inhibitors of caspases but not by inhibitors of Ser, Cys, Asp, or metalloproteinases. Using primers based on the nucleotide sequence of known members of Ced-3/interleukin-1β-converting enzyme (ICE) family from human origin, we have identified by reverse-transcription (RT) polymerase chain reaction (PCR) analyses that rat kidney transcribes the genes for caspase-1 (ICE), caspase-2 (Nedd2), caspase-3 (CPP32), and caspase-6 (Mch2). RT-PCR products, when subcloned and sequ

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Wcisło-Dziadecka, Dominika, Klaudia Simka, Agata Kaźmierczak, et al. "Psoriasis Treatment Changes the Expression Profile of Selected Caspases and their Regulatory MicroRNAs." Cellular Physiology and Biochemistry 50, no. 2 (2018): 525–37. http://dx.doi.org/10.1159/000494166.

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Background/Aims: Psoriasis, an autoimmune diseases of the skin, characterized by patches of abnormal/inflammed skin, although not usually life-threatening, it causes severe discomfort, esthetic impairments, and may lead to impaired social functions and social withdrawal. Besides UV-phototherapy, various anti-inflammatory treatments are applied, depending on the severity of symptoms. In 2008, adalimumab (fully humanized human anti-TNF antibody) was launched for the treatment of psoriasis. In the quest to better understand the pathomechanism of adalimumab’s therapeutic effects, and the acquired

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Bhattacharya, Sujoy, Ramesh M. Ray, Mary Jane Viar та Leonard R. Johnson. "Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-α in IEC-6 cells". American Journal of Physiology-Gastrointestinal and Liver Physiology 285, № 5 (2003): G980—G991. http://dx.doi.org/10.1152/ajpgi.00206.2003.

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Intracellular polyamine homeostasis is important for the regulation of cell proliferation and apoptosis and is necessary for the balanced growth of cells and tissues. Polyamines have been shown to play a role in the regulation of apoptosis in many cell types, including IEC-6 cells, but the mechanism is not clear. In this study, we analyzed the mechanism by which polyamines regulate the process of apoptosis in response to tumor necrosis factor-α (TNF-α). TNF-α or cycloheximide (CHX) alone did not induce apoptosis in IEC-6 cells. Significant apoptosis was observed when CHX was given along with T

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8

Ali, Shujath M., Victoria Y. Wong, Kristine Kikly, et al. "Apoptosis in polycystic kidney disease: involvement of caspases." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 278, no. 3 (2000): R763—R769. http://dx.doi.org/10.1152/ajpregu.2000.278.3.r763.

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Polycystic kidney disease (PKD) is characterized by the development of large renal cysts and progressive loss of renal function. Although the cause of the development of renal cysts is unknown, recent evidence suggests that excessive apoptosis occurs in PKD. With the use of terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, we have confirmed the presence of apoptotic bodies in cystic kidneys of congenital polycystic kidney (cpk) disease mice carrying a homozygous mutation at 3 wk of age. Apoptosis was localized primarily to the interstitium with little evidence of cell deat

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Wang, Jinzhao, Navjotsingh Pabla, Cong-Yi Wang, Weixin Wang, Patricia V. Schoenlein, and Zheng Dong. "Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53." American Journal of Physiology-Renal Physiology 291, no. 6 (2006): F1300—F1307. http://dx.doi.org/10.1152/ajprenal.00509.2005.

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Cisplatin induces renal cell injury and death, resulting in nephrotoxicity that limits its use in cancer therapy. Using cell culture models, recent work has suggested the involvement of p53 in renal cell apoptosis during cisplatin treatment. However, the signals upstream of p53 remain elusive. ATM and ATR are critical regulators of p53 under various conditions of DNA damage. Here, we show that ATM, and not ATR, was proteolytically cleaved into specific fragments of ∼210 and 150 kDa during cisplatin-induced tubular cell apoptosis. ATM cleavage was paralleled by the development of apoptosis. VAD

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Fischer, Uwe M., Charles S. Cox, Glen A. Laine, Uwe Mehlhorn, Wilhelm Bloch, and Steven J. Allen. "Induction of cardioplegic arrest immediately activates the myocardial apoptosis signal pathway." American Journal of Physiology-Heart and Circulatory Physiology 292, no. 3 (2007): H1630—H1633. http://dx.doi.org/10.1152/ajpheart.00006.2005.

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Myocardial ischemia-reperfusion, including cardioplegic arrest (CA), has been associated with cardiac apoptosis induction. However, the time course of apoptosis activation and the trigger mechanisms are still unclear. Because apoptosis inhibition may represent a novel therapeutic strategy for long-term myocardial preservation, we sought to investigate the time course of apoptosis signal-pathway induction during CA. As to method, Sprague-Dawley rats (300–350 g) were anesthetized, intubated, and mechanically ventilated. CA was initiated by infusion of ice-cold crystalloid solution (Custodiol, 10

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Dissertations / Theses on the topic "Caspases – physiology"

1

Yang, Jie. "STRUCTURE, FUNCTION, AND REGULATION OF INFLAMMATORY CASPASES IN INFLAMMATION AND PYROPTOSIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1560267566637531.

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Nhan, Thomas Q. "Physiologic functions of activated caspases in macrophages /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/6311.

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Ruest, Louis-Bruno. "Peptide elongation factors and caspase-3 in myocytes : a way to control apoptosis." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38269.

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Few weeks after birth, a switch in peptide elongation factor 1As from EF-1alpha/EF1A-1 to S1/EF1A-2 occurs in brain neurons, heart and skeletal muscles of mammalians. In order to elucidate the reason behind this switch, I studied the expression of both homologous proteins during muscle differentiation and apoptosis and, documented the relation between peptide elongation factors and caspase-3 activation. I found that during in vitro muscle differentiation of L6 myoblasts, a switch in peptide elongation factors 1A occurs as physiologically observed in skeletal muscles. While EF-1alpha/EF1A-1 is

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White, Lloyd. "Characterisation of caspase- 14 in the human placenta : evidence for trophoblast-specific inhibition of differentiation by caspase- 14." University of Western Australia. School of Anatomy and Human Biology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0160.

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[Truncated abstract] The placenta forms a barrier regulating the transfer of gases, nutrients and wastes between the mother and the developing conceptus, and also produces hormones affecting both the fetus and the mother. This barrier is formed by the differentiation of the outer layer of the blastocyst- the trophoblast- to facilitate implantation and subsequent invasion of the uterus. The trophoblast consists of an underlying proliferative pool of cytotrophoblasts, which differentiate to replenish the overlying continuous, multi-nucleated syncytiotrophoblast that forms the barrier between the

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Kannan, Harsha. "The Inflammasome in Acute Myocarditis." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3108.

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Acute myocarditis is an acute inflammatory syndrome characterized by myocardial damage and dysfunction often due to a viral infection followed by a variable development over time. There are currently no specific treatments and standard treatments for heart failure are generally applied. The inflammasome is a recently identified macromolecular structure that occupies a central role in the amplification of the inflammatory response and promotion of cell death during acute and chronic infections. We hypothesized the formation of the inflammasome in acute myocarditis. To investigate, samples of pa

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Lacelle, Chantale. "Blood sample processing for the study of aging, and characterization of caspase mRNA expression in peripheral blood mononuclear cells." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82906.

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Centenarian population studies are one of several approaches currently used to study the aging process and characterize successful aging. I have described a methodology permitting the simultaneous generation of RNA, DNA, protein, and plasma samples, as well as fixed peripheral blood mononuclear cells (PBMC) and frozen blood aliquots, from a single 10- to 30-ml sample of peripheral blood obtained from donors of any age, and showed that although extremely old individuals are somewhat anemic, it is possible to obtain enough biological material from their blood to conduct aging studies.<br>

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Trueblood, Katherine Eileen. "Caspase-1-Dependent Inflammatory Signaling in Retinal Müller Cells During the Development of Diabetic Retinopathy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1322483450.

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Léger, Thibaut. "Analyse protéomique de l'apoptose chez Candida albicans : activité protéasique de la métacaspase Mca1p et conséquences biologiques." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC157.

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Candida albicans est une levure commensale de la flore intestinale, des muqueuses et des épithéliums et un pathogène causant des candidoses bénignes mais aussi de graves infections systémiques. Comprendre et manipuler la réponse apoptotique de C. Albicans peut aider à contrôler ce pathogène opportuniste. La métacaspase Mca1p est une protéine clé dans la réponse apoptotique de C. Albicans. Cependant, sa spécificité de clivage et ses substrats sont peu caractérisés. Nous avons donc soumis des souches sauvage et délétée pour le gène Mca1 à la molécule de quorum sensing farnésol et ensuite étudié

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Djebaili, Myriam. "Etude des phénomènes de mort neuronale induits in-vivo et in-vitro après l'action de l'acide kai͏̈nique ou du N-méthyl-D-aspartate dans l'hippocampe de souris : implication des protéines p53, bax et caspase-3 dans les phénomènes de mort neuronale par apoptose." Montpellier 2, 2001. http://www.theses.fr/2001MON20088.

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Rocha, Eduardo Augusto Victor. "Avaliação da apoptose e neoangiogênese miocárdica no treinamento ventricular de cabritos jovens submetidos à sobrecarga de pressão contínua versus intermitente." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-06022017-155911/.

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Introdução: A correção anatômica da transposição das grandes artérias após o período neonatal demanda a preparação prévia do ventrículo subpulmonar, com bandagem do tronco pulmonar, para induzir a hipertrofia ventricular. Estudos experimentais prévios demonstraram que a sobrecarga sistólica intermitente determina uma hipertrofia ventricular mais eficiente, em relação à bandagem convencional (fixa) do tronco pulmonar. Os mecanismos adaptativos envolvidos no retreinamento do ventrículo subpulmonar ainda não estão completamente estabelecidos, pois se sabe que, além da hipertrofia e hiperplasia da

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Books on the topic "Caspases – physiology"

1

Mor, Gil, and Ayesha B. Alvero. Apoptosis and cancer: Methods and protocols. Humana Press, 2015.

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R, Ruffolo Robert, Walsh Frank, and SmithKline Beecham Pharmaceuticals United States Research Symposium (11th : Collegeville, Pa.), eds. Apoptosis in health and disease. Harwood Academic, 2000.

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Apoptosis and cancer: Methods and protocols. Humana Press, 2007.

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Gil, Mor, and Alvero Ayesha B, eds. Apoptosis and cancer: Methods and protocols. Humana Press, 2008.

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(Editor), Gil Mor, and Ayesha Alvero (Editor), eds. Apoptosis and Cancer: Methods and Protocols (Methods in Molecular Biology). Humana Press, 2007.

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Design of caspase inhibitors as potential clinical agents. Taylor & Francis, 2009.

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Design of Caspase Inhibitors as Potential Clinical Agents (Enzyme Inhibitors). CRC, 2008.

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Book chapters on the topic "Caspases – physiology"

1

Truong-Tran, Ai Q., Joanne Carter, Richard E. Ruffin, and Peter D. Zalewski. "The role of zinc in caspase activation and apoptotic cell death." In Zinc Biochemistry, Physiology, and Homeostasis. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-3728-9_7.

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