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Journal articles on the topic 'Castor oil-induced gastric enteropooling'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Ezeigbo, I.I, C.E.C.C. Ejike, M.I. Ezeja, and O. Eneh. "ANTIOXIDANT AND ANTIDIARRHOEAL ACTIVITY OF Manniophyton africanum LEAF EXTRACT IN MICE." Continental J. Animal and Veterinary Research 2 (June 16, 2010): 41–47. https://doi.org/10.5281/zenodo.818031.

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The antidiarrhoeic activity of the methanolic leaf extract of <em>Manniophyton africanum </em>(MEMA) has been evaluated out in mice using different models (Castor oil-induced diarrhoea, effects on gastrointestinal motility, and castor oil-induced gastric enteropooling). MEMA (200,400 and 600 mg/kg, p.o.) inhibited at 5% significance level, the frequency of defecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, markedly inhibited the movement of charcoal meal plug through the gastrointestinal tract, in a dose dependent manner, comparable to diphenoxylate and atr

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Madubuike, K. G., M. I. Ezeja, and I. I. Ezeigbo. "ANTIDIARRHOEAL ACTIVITY OF Pterocarpus santalinoides LEAF EXTRACT IN MICE." Continental J. Animal and Veterinary Research 4, no. 1 (2012): 1–6. https://doi.org/10.5281/zenodo.818249.

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The antidiarrhoeal activity of the methanolic leaf extract of <em>Pterocarpus</em> <em>santalinoides</em> was evaluated in mice using different experimental models: castor oil – induced diarrhoea, gastrointestinal motility test and castor oil – induced enteropooling. The extract (200,400 and 800 mg/kg, p.o.) significantly (p < 0.05) reduced the number of wet faeces in the castor oil – induced diarrhoea, as well as inhibited the movement of charcoal meal plug through the gastrointestinal tract. Both actions were dose – dependent and comparable to those of Loperamide, used as the positive con

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3

Konate, Kiessoun, Meda Nag Tiero Roland, Diao Mamounata, et al. "ANTIMICROBIAL PROFILES, ANTIDIARRHEAL AND ANTIPYRETIC CAPACITIES OF PHENOL ACID RICH-FRACTIONS FROM XIMENIA AMERICA L., (OLACACEAE) IN WISTAR ALBINO RATS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 10 (2018): 62. http://dx.doi.org/10.22159/ijpps.2018v10i10.25485.

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Objective: The present study aim to evaluate antimicrobial and antidiarrheal activities of phenol acid-rich fractions of roots from Ximenia americana L., in animal models in order to confirm the ethnomedicinal use of Ximenia Americana L., roots.Methods: In vitro antibacterial (Minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC) and time-kill studies) of phenol-rich fractions of roots from Ximenia americana L., was assessed using eight bacteria strains (Gram-negative). The anti-diarrheal activity was evaluated using castor using castor oil induced diarrhea whereas A

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Ismail, H. A., H. S. Hassan, M. Ilyas, A. A. Sadam, and A. A. Sadam. "Evaluation of Phytochemical and Anti-diarrheal Activity of Methanol Stembark Extract of Combretum hypopilinum Diels (Combretaceae)." Nigerian Journal of Pharmaceutical Research 17, no. 1 (2021): 45–52. http://dx.doi.org/10.4314/njpr.v17i1.5.

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Introduction: The plant Combretum hypopilinum has many medicinal uses in Africa. Infusion of fresh or dry leaves are commonly taken as cholagogic, diuretic, and purgative and also to treat gastrointestinal disorders, including diarrhoea, dysentery, and stomach achesObjective: To carry out phytochemical and antidiarrheal studies on the methanol stembark extract of C. hypopilinum.Methods: The C. hypopilinum stembark (1kg) were extracted with methanol using cold maceration method for 9 days. The solvent was removed by rotary evaporator and the extract was partitioned with n-hexane, chloroform and

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Ansari, Sameen Fatima, Arif-ullah Khan, Neelum Gul Qazi, Fawad Ali Shah, and Komal Naeem. "Proteomic Analysis and In Vivo Studies Reveal the Potential Gastroprotective Effects of CHCl3 and Aqueous Extracts of Ficus palmata." Evidence-Based Complementary and Alternative Medicine 2021 (May 30, 2021): 1–11. http://dx.doi.org/10.1155/2021/6613140.

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Ficus palmata is rich in several phytochemicals such as chromone, isoflavones, terpenes, lignans, coumarins, glycosides, and furanocoumarins and have been traditionally used for the management of different gastrointestinal disorders. This research reveals the effects of Ficus palmata fruit extracts—Ficus palmata chloroform (Fp.CHCl3) and Ficus palmata aqueous (Fp.Aq)—on gut activity through in vivo and in vitro analyses. Antidiarrheal and enteropooling assays were analyzed with castor oil-induced diarrhea and intestinal fluid accumulation. Jejunum tissues of rabbits were isolated (antispasmodi

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Shah, Rushabh S., Jeet Ravat, Misbah A. Momin, and Alka P. Mukne. "Antidiarrheal activity of aqueous extract of leaves of Euphorbia hirta L." Journal of Pharmacy & Pharmacognosy Research 9, no. 5 (2021): 716–29. http://dx.doi.org/10.56499/jppres21.1054_9.5.716.

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Context: Euphorbia hirta L. is widely distributed in the Indian subcontinent and has many ethnomedicinal uses. Traditionally, the leaves of E. hirta have been used as antidiarrheal agents, for bronchial and respiratory diseases and against conjunctivitis. Aims: To evaluate the antidiarrheal activity of the aqueous extract of leaves of Euphorbia hirta. Methods: Steam and aqueous extracts of leaves of E. hirta were evaluated for their antidiarrheal activity by in vitro antiprotozoal and antimicrobial activity testing, in vivo evaluation of % protection against diarrhea in castor-oil induced rat

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A., Nwabunike I., Okoli C. O., Ezeugwu P., et al. "ANTIDIARRHEAL POTENTIALS OF SCHWENCKIA AMERICANA L. (SOLANACEAE): A COMPARATIVE STUDY OF THE AERIAL PART AND ROOT EXTRACTS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 1 (2018): 195. http://dx.doi.org/10.22159/ijpps.2018v10i1.21928.

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Objective: Schwenckia americana L. (Solanaceae) is employed as a decoction of either the leaves, roots or the whole plant in the treatment of diarrhoea in most West African countries. Using a comparative study approach, the antidiarrheal potentials of its aerial part and root extracts were evaluated to substantiate its local use in diarrhoea management.Methods: In vivo effects of the extracts on rodent models of diarrhea, enteropooling and gastric motility induced by castor oil were investigated as well as their effects on acetylcholine and histamine-induced guinea pig ileal contractions in vi

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Joseph Olanrewaju Oyindamola, Godwin Christian Akuodor, Malachy Ifeanyi Obi, Evelyn Ogochukwu Nwachukwu, Kingsley Chimsorom Chilaka, and Omo Eric Irinmwinuwa. "Comparative assessment of the anti-diarrhoeal effects of the ethanol leaf and stem extracts of lantana camara in Wistar rats." Magna Scientia Advanced Research and Reviews 3, no. 1 (2021): 035–45. http://dx.doi.org/10.30574/msarr.2021.3.1.0059.

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The antidiarrhoeal effects of Lantana camara ethanol leaf and stem extracts were compared in Wistar rats. The phytochemical and acute toxicity tests were also determined. The extracts were evaluated for castor oil- induced diarrhoea and enteropooling as well as intestinal transit in rats. The ethanol stem extract produced significant (P < 0.05), while the ethanol leaf extract produced significant (P < 0.01) dose dependent protection on rats against castor oil induced diarrhoea. The stem extract inhibited intestinal transit time and caused significant (P < 0.05), while leaf extract cau

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Kamadyaapa, Davie Rexon, Mavuto Masopera Gondwe, Mathulo Shauli, Constance Sewani Rusike, and Jehu Iputo. "EVALUATION OF ANTIDIARRHEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF ERIOBOTRYA JAPONICA LINDL." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (2018): 502. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.27256.

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Objective: The study was carried out to investigate the antidiarrheal activity of ethanolic leaf extract of Eriobotrya japonica (EEJ) using various models of experimental diarrhea.Methods: Antidiarrheal property of EEJ at 100, 200, and 400 mg/kg/bwt was evaluated using castor oil-induced diarrhea, castor oil-induced enteropooling, and gastrointestinal propulsive models of experimental diarrhea in Sprague Dawley rats of both sexes, weighing 200–250 g. Cytotoxicity test of EEJ was performed using brine shrimp bioassay.Results: Toxicity assay of EEJ showed a lethal concentration value of 1225 μg/

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Akuodor, Godwin Christian, Grace Akanimo Essiet, John Azubuike Ekenjoku, et al. "Antidiarrhoael and antimicrobial effects of ethanol root bark extract from Salacia lehmbachii." Journal of Herbmed Pharmacology 10, no. 2 (2021): 188–93. http://dx.doi.org/10.34172/jhp.2021.20.

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Introduction: The roots of Salacia lehmbachii are used in Nigerian folklore medicine without scientific basis. The present study was aimed to investigate the antidiarrheal and antimicrobial activities of the ethanol extract of S. lehmbachii root bark. Methods: The antidiarrheal activity was examined using castor oil induced diarrhoea method. The ethanol root bark extract effects on intestinal transit time and enteropooling were also evaluated in rats, while antimicrobial activity was conducted on selected microorganisms. The acute toxicity test and phytochemical screening of the extract were a

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Mayela Nkouka, S. H. J., D. S. Kiéssé, R. D. G. Elion Itou, A. W. Etou Ossibi, and A. A. Abena. "Evaluation of antidiarrheal effect of the aqueous extract of the leaves of Chromolaena odorata L (King and Robinson)." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 367–71. http://dx.doi.org/10.22270/jddt.v9i2.2392.

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This study aimed to evaluate the antidiarrheal effect of the aqueous extract of the leaves of C odorata (400 and 800 mg/kg). ¶The antidiarrheal effect was evaluated on the diarrhoea induced by the castor oil, the charcoal test (intestinal transit time) and on the accumulation of the intestinal fluid induced by the castor oil (Enteropooling).¶The results obtained show that the aqueous extract at the doses used significantly decrease (p<0,001) the frequency of emission, the quantity and the onset of appearance of the faces induced by the castor oil. ¶The aqueous extract of C odorata (400 and

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Sanni, Fatimah Saka, Hajja Gana Hamza, and Patrick Azubuike Onyeyili. "Antidiarrheal activity of fractions from aqueous extract of Detarium senegalense." Herba Polonica 61, no. 2 (2015): 30–40. http://dx.doi.org/10.1515/hepo-2015-0013.

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Summary The aim of this study was to evaluate the effect of different fractions of the aqueous crude extract of Detarium senegalense stem bark on castor oil-induced diarrhea. Castor oilinduced diarrhea, gastrointestinal motility and castor oil-induced enteropooling methods were used to evaluate the antidiarrheal effects of the fractions. Castor oil was used to induce diarrhea and the effect of all the fractions (chloroform, ethyl acetate, n-butanol, methanol and residual aqueous) were evaluated at the doses of 200 and 400 mg/kg body weight. The results show that all fractions significantly (p&

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Njoku, Ugochi Olivia, and Obinna Martins Ogugofor. "Anti-diarrhoeal effect of methanol leaf fraction of Cola hispida Brenan and Keay in rats." Tropical Journal of Pharmaceutical Research 20, no. 7 (2022): 1455–62. http://dx.doi.org/10.4314/tjpr.v20i7.19.

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Purpose: To evaluate the anti-diarrhoeal activity of 20 % methanol leaf fraction of Cola hispida (MLFC) using castor oil-induced diarrhoea model in rats. Methods: The activity of MLFC against castor oil-induced diarrhoea, intestinal fluid accumulation (enteropooling), and gastrointestinal motility were evaluated. The experimental animals were grouped into five, each with four animals. Group 1 received distilled water, while group 2 received loperamide and served as negative and standard control groups respectively. Groups 3 - 5 were administered 200, 400 and 600 mg/kg of MLFC respectivel

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Njoku, Ugochi Olivia, and Obinna Martins Ogugofor. "Anti-diarrhoeal effect of methanol leaf fraction of Cola hispida Brenan and Keay in rats." Tropical Journal of Pharmaceutical Research 20, no. 7 (2022): 1455–62. http://dx.doi.org/10.4314/tjpr.v20i7.

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Purpose: To evaluate the anti-diarrhoeal activity of 20 % methanol leaf fraction of Cola hispida (MLFC) using castor oil-induced diarrhoea model in rats. Methods: The activity of MLFC against castor oil-induced diarrhoea, intestinal fluid accumulation (enteropooling), and gastrointestinal motility were evaluated. The experimental animals were grouped into five, each with four animals. Group 1 received distilled water, while group 2 received loperamide and served as negative and standard control groups respectively. Groups 3 - 5 were administered 200, 400 and 600 mg/kg of MLFC respectivel

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Odenigbo, Abel, Peter A. Akah, Emmanuel E. Ilodigwe, et al. "Preliminary Evaluation of the Antidiarrheal Effects of Ethanol Leaf Extract and Fractions of Rauwolfia vomitoria Afzel. (Apocynaceae)." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 15 (May 2020): 11–21. http://dx.doi.org/10.18052/www.scipress.com/ijppe.15.11.

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Context: Diarrhea, a major leading cause of death among under-five children in developing countries is still ravaging the society today due to limitations associated with conventional treatment approaches. The leaf of Rauwofia vomitoria (R. vomitoria) is used by the locals in Nigeria for the treatment of diarrhea. Aim: This study evaluated the anti-diarrheal activity of the leaf extract and fractions of R. vomitoria using animal models. Methods: Phytochemical screening of the extract was carried out. The extracts and fractions of R. vomitoria were screened using castor-oil induced diarrhea, ca

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Megwas, Anthony Uchenna, Godwin Christian Akuodor, Leo Clinton Chukwu, et al. "Gastroprotective potential of Annona senegalensis ethanol leaf extract in Wistar rats." Journal of Biological Studies 5, no. 2 (2022): 270–84. http://dx.doi.org/10.62400/jbs.v5i2.6647.

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The leaves of Annona senegalensis are traditionally used for the treatment of different diseases in Nigeria, including gastrointestinal disorders. The anti-diarrheal and ulcer-protective activities of its ethanol extract were determined in Wistar rats. This extract was investigated for castor oil-induced diarrhoea, intestinal transit time and castor oil-induced enteropooling in rats. The leaf extract was also tested for its ulcer protective potentials in acetylsalicylic acid, ethanol and stress-induced ulceration in rats. The phytoconstituents and oral acute toxicity of the leaf extract were a

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Mahmud, Bukhari, Lawan Ijudigal, Ibrahim Yunusa, Aishatu Shehu, and Mohammed Garba Magaji. "Activity of methanol root extract of Parquetina nigrescens (Afzel.) Bullock on castor oil-induced diarrhoea in mice." Journal of Pharmacy & Bioresources 17, no. 2 (2021): 180–88. http://dx.doi.org/10.4314/jpb.v17i2.12.

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This study aimed at providing pharmacological rationale for the ethnomedicinal use of Parquetina nigrescens root in the treatment of diarrhoea. The antidiarrhoeal activity of methanol root extract of P. nigrescens(MPN) was determined using castor oil-induced diarrhoea (COD), castor oil-induced enteropooling (COE) and gastrointestinal motility (GIT) tests. In COD, MPN at all doses significantly (p≤0.01) delayed the onset of diarrhoea and significantly (p≤0.05) decreased the number of wet faeces (with percentage inhibition of 52.2; 53.33 and 71.13 at 25, 50 and 100 mg/kg) respectively. The frequ

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Khan, N., S. Hugar, V. Patil, H. M. Nanjappaiah, E. N. Gaviraj, and N. V. Kalyane. "EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF PUNICA GRANATUM STEM BARK." INDIAN DRUGS 50, no. 09 (2013): 34–40. http://dx.doi.org/10.53879/id.50.09.p0034.

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Evaluation of anti-diarrhoeal effect of Punica granatum stem bark ethanolic extract was carried out on various experimental animal models of diarrhea. Different paragons used were castor oil induced diarrhoea, magnesium sulphate induced diarrhoea, castor oil induced enteropooling and gastrointestinal motility test. The various parameters recorded were onset of diarrhoea, mean number of fecal drops, mean weight of fecal matter, mean weight of small intestine, volume of fluid accumulation in the intestine and mean distance travelled by charcoal meal in the intestine. The test extract demonstrate

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ADAMU, Muazu Alkali, Suleiman Ali, and Musa Magaji Jawa. "Phytochemical and Anti-Diarrhoeal Potential of Ipomea batatas Leaf Solvent Extract on Castor Oil Induced Diarrhoeal Rat Model." International Journal of Research and Innovation in Applied Science IX, no. VI (2024): 271–86. http://dx.doi.org/10.51584/ijrias.2024.906025.

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The folkloric claim of Ipomoea batatas extracts in the management of diarrhoea is yet to be substantiated or refuted with scientific data. Therefore, the present study was aimed to screen the extracts of I. batatas for both its secondary metabolites, acute toxicity, and antidiarrhoeal activity at 125, 250, and 500 mg/kg body weight in rats and elemental analysis of the most active extract. The most active extract was screened for elemental analysis. Secondary metabolites were screened using standard methods while the antidiarrhoeal activity was done by adopting the castor oil-induced diarrhoea

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Yakubu, Musa T., Quadri O. Nurudeen, Saoban S. Salimon, et al. "Antidiarrhoeal Activity ofMusa paradisiacaSap in Wistar Rats." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/683726.

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The folkloric claim ofMusa paradisiacasap in the management of diarrhoea is yet to be substantiated or refuted with scientific data. Therefore, the aim of the current study was to screen the sap ofM. paradisiacafor both its secondary metabolites and antidiarrhoeal activity at 0.25, 0.50, and 1.00 mL in rats. Secondary metabolites were screened using standard methods while the antidiarrhoeal activity was done by adopting the castor oil-induced diarrhoeal, castor oil-induced enteropooling, and gastrointestinal motility models. The sap contained flavonoids, phenolics, saponins, alkaloids, tannins

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Jahan, Nusrat, Jannatul Ferdousi, Md Jahir Alam, Tasmina Rahman, Mizanur Rahman, and Masum Shahriar. "Antidiarrheal Activity of Ethanolic Extract of Melochia corchorifolia L. and Glochidion thomsonii in Experimental Animal Models." Bangladesh Pharmaceutical Journal 22, no. 2 (2019): 192–99. http://dx.doi.org/10.3329/bpj.v22i2.42304.

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Diarrhoea is a public health problem in developing countries. It is therefore important to identify plants with antidiarrhoeal activity. Melochia corchorifolia and Glochidion thomsonii have been used in folk medicine to alleviate several diseases. The present study was performed to investigate the anti-diarrheal properties of ethanolic extract of M. corchorifolia whole plant and G. thomsonii bark. Anti-diarrheal potential was evaluated using castor oil and MgSO4 induced diarrhea, GI motility test as well as castor oil induced enteropooling assay in mice. Extracts were used at 250 and 500 mg/kg

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Khan, Imran Ahmad, Khalid Hussain Janbaz, and Fatima Saqib. "Antidiarrheal activity of methanolic leaf extract of Rumex vesicarius." Bangladesh Journal of Pharmacology 11, no. 1 (2016): 175. http://dx.doi.org/10.3329/bjp.v11i1.24251.

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<p>This study evaluates the antidiarrheal activity of <em>Rumex vesicarius</em> (leaf) by using in vitro and in vivo assays. Antidiarrheal effect of <em>R. vesicarius</em> was evaluated using castor oil-induced diarrhea model in rat. Weight and volume of the intestinal content were assessed using the enteropooling method. Atropine (3 mg/kg, i.p) was used as positive control. <em>R. Vesicarius</em> at the doses of 200 and 400 mg/kg p.o. significantly retarded castor oil-induced enteropooling and intestinal transit. The gastrointestinal transit rate was

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Hossain, Mohammad Shahadat, Ziku Chandra Dey, Md Imdadul Hoque, Md Saddam Hossain Bhuiyan, and Hasan Al Banna. "Evaluation of antidiarrheal and antinociceptive activity of methanolic extract of Alstonia scholaris Linn. on mice models." Journal of Phytopharmacology 3, no. 6 (2014): 423–30. http://dx.doi.org/10.31254/phyto.2014.3609.

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Alstonia scholaris is an indigenous medicinal plant of Bangladesh. The leaves have been used traditionally as folk remedies for the treatment of many diseases including diarrhea, dysentery, and malaria and snake bites. The ripe fruits of the plant are used in syphilis and epilepsy. It is also used as a tonic, anti-periodic, and anthelmintic. However, there was no study on whole plant extract of Alstonia scholaris. The present study designed to investigate the anti-nociceptive and anti-diarrheal activities of Alstonia scholaris on animal models at different doses such as 200 mg/kg and 400 mg/kg

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Biozid, Md. Shahrear, Mohammad Nazmul Alam, Md. Jainul Abeden, et al. "Assessment of in-vivo anti-diabetic and anti-diarrheal effects of Flemingia stricta Roxb. leaf." European Journal of Biological Research 10, no. 2 (2020): 156–66. https://doi.org/10.5281/zenodo.3839749.

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The objective of this study was to evaluate the anti-diabetic and anti-diarrheal activity of methanol extract of <em>Flemingia stricta </em>Roxb. (Fabaceae) leaf. In anti-diabetic study, the extract was administered to alloxan-induce diabetic mice at two concentrations (200 mg/kg and 400 mg/kg body weight) for acute (12 hours) and prolong treatments (15 days) and blood glucose levels of diabetic mice were monitored at intervals of hours and days throughout the duration of treatment. Antidiarrheal test was conducted by castor oil induced diarrhea and enteropooling as well as intestinal motility

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Mekonnen, Belay, Assefa Belay Asrie, and Zewdu Birhanu Wubneh. "Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/3037120.

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Background. Diarrhea is one of the leading causes of preventable death in developing countries and mainly affects children and infants. It has been reported that the leaf of Justicia schimperiana is used as an antidiarrheal agent in Libo Kemekem district, northwest Ethiopia. Method. The 80% methanolic leaf extract of J. schimperiana was evaluated for its activity against castor oil-induced diarrhea, enteropooling, and gastrointestinal motility in mice. Results. Significant reduction (p<0.001) in the total defecation and diarrheal drops was produced by all the test doses of the extract. Perc

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Teferi, Meseret Yigzaw, Mohammedbirhan Abdulwuhab, and Jibril Seid Yesuf. "Evaluation of In Vivo Antidiarrheal Activity of 80% Methanolic Leaf Extract of Osyris quadripartita Decne (Santalaceae) in Swiss Albino Mice." Journal of Evidence-Based Integrative Medicine 24 (January 1, 2019): 2515690X1983334. http://dx.doi.org/10.1177/2515690x19833340.

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The leaf of Osyris quadripartita is traditionally used for the management of diarrhea in different parts of Ethiopia. However, its use has not been scientifically validated for its efficacy. The aim of this study was to investigate antidiarrheal activity of hydroalcoholic leaf extract of O. quadripartita in mice models. Different doses of the methanolic leaf extract of O. quadripartita (100, 200, and 400 mg/kg) were tested for antidiarrheal activity using castor oil–induced diarrhea, enteropooling, and gastrointestinal motility models in Swiss Albino mice. The activities of the extract at diff

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Akuodor, Godwin C., Ndubuisi N. Nwobodo, Anthony U. Megwas, et al. "Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark." Journal of Basic and Clinical Physiology and Pharmacology 29, no. 2 (2018): 211–16. http://dx.doi.org/10.1515/jbcpp-2016-0174.

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AbstractBackground:TheIcacina senegalensisroot bark is traditionally used for the treatment of gastrointestinal disorders in Nigeria. To date, no scientific study has substantiated or refuted this claim.Methods:The antidiarrheal and antimicrobial activities of the ethanol root bark extract were investigated in rats and against some selected diarrhea-causing microorganisms.Results:The extract significantly decreased the frequency of castor oil-induced diarrhea, and inhibited the masses and volumes of intestinal fluid accumulation in the castor oil-induced enteropooling method. The distance trav

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BULUS, Rimamnungra Ibrahim, Rimamtsiwe Adi BURBA, and Paul Ifeleke OYEGOKE. "ANTIDIARRHOEAL POTENTIAL OF FRACTIONS OBTAINED FROM METHANOL EXTRACT OF BRIDELIA ATROVIRIDIS (EUPHORBIACEAE) LEAVES ON CASTOR OIL-INDUCED DIARRHOEA IN SWISS ALBINO MICE." Anchor University Journal of Science and Technology 4, no. 2 (2024): 171–82. http://dx.doi.org/10.4314/aujst.v4i2.6.

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Background: Diar r hoea constitutes a major health concern, especially for children under the age of five. Orthodox drugs available for the treatment of diarrhoea are fraught with some challenges not limited to high cost, adulteration and toxic side effects, thereby making a case for alternative remedies, with several medicinal plants known to contain biologically active components that possess curative properties against diarrhoea.Objective: The study was under taken to evaluate the effect of fr actions (ethylacetate, n-butanol and residual aqueous) obtained from methanol extract of Bridelia

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Anas, Yance, Desi Rakhmawati, Layyinatul Fuadah, and Nola Carina Rahayu. "EFEK ANTIDIARE EKSTRAK ETANOL DAUN PARIJOTO (Medinilla speciosa Blume) PADA MENCIT JANTAN GALUR BALB/C." JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik 16, no. 01 (2019): 28. http://dx.doi.org/10.31942/jiffk.v16i01.2926.

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ABSTRACTParijoto is one of a rare plant species in Indonesia, and its leaves have traditionally been utilized to treat diarrhea in the area of Kudus Regency, Indonesia. Parijoto leaves contain active compounds of tannin and flavonoid which have antidiarrheal properties. This investigation intends to demonstrate the antidiarrheal effect of parijoto leaf ethanol extract (EEDP) on male Balb/C mice castor oil-induced diarrheal and reveal its antidiarrheal mechanism through antimotility and antisecretory testing. EEDP made by maceration method. The antidiarrheal effects of three series level EEDP (

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Ababsa, Zine El Abidine, Mohamed Tahar Derouiche, Kamel Medjroubi, and Salah Akkal. "In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of the Cupressaceae family." Acta Scientifica Naturalis 6, no. 1 (2019): 50–53. http://dx.doi.org/10.2478/asn-2019-0007.

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Abstract Tetraclinis articulata (Thuya of Barbary), endemic to North Africa, is used as a traditional medicine for the treatment of many diseases [1]. We investigated the antidiarrhoel properties of the butanol extract of Tetraclinis articulata (BETA) in male and female Swiss albino mice to support its traditional use. The antidiarrhoeal activity of the plant extract was evaluated in a model of castor oil-induced diarrhoea model in mice and compared to loperamide (a reference inhibitor of diarrhoea). The effect of (BETA) on gastrointestinal motility was determined by the oral administration of

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Amuzat, Aliyu, Yakubu Ndatsu, Mohammed Adisa, et al. "Anti-diarrhoeal Effects of Aqueous Extract of Vitex doniana Stem Bark in Castor Oil-induced Wistar Rats." Tanzania Journal of Science 46, no. 3 (2020): 723–32. http://dx.doi.org/10.4314/tjs.v46i3.13.

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Vitex doniana is a medicinal plant commonly used in traditional medicine for the treatment of diarrhoea-related disorders. In the present study, aqueous extract of Vitex doniana stem back was evaluated for anti-diarrhoeal effects. Thirty albino rats of average weight 124 ± 4.35 g were distributed into five groups. Groups 1, 2, 3, 4 and 5 were orally administered 2 mL of normal saline, 2.5 mg/kg bodyweight (bw) loperamide, 100, 200, 400 mg/kg bodyweight of aqueous extract of V. doniana stem back, respectively. The extract was evaluated using feacal characteristics, gastrointestinal motility and

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Abdullahi, Z., A. A. Jimoh, B. E. Patrick, M. I. Yakubu, and D. Mallam. "IN-VIVO ANTI-DIARRHOEAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF ETHANOL STEM BARK EXTRACT OF VITELLARIA PARADOXA GAERTN F. (SAPOTACEAE)." FUDMA JOURNAL OF SCIENCES 4, no. 3 (2020): 247–51. http://dx.doi.org/10.33003/fjs-2020-0403-388.

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Different parts of Vitellaria paradoxa plant have many applications in ethno-medicine. Some of the uses of this plant include treatment of diarrhoea and other GIT disorders. In this study the antidiarrhoeal activity of the ethanol extract of Vitellaria paradoxa was evaluated using three experimental models: Castor oil-induced diarrhoea; small intestinal motility and intestinal fluid accumulation (enteropooling) models in mice. Five groups of five mice were used for each model. Group one mice received 10 ml/kg of distilled water, while groups 2, 3, and 4 received 125, 250 and 500 mg/kg of the e

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Zayede, Dessie, Tafere Mulaw, and Wubayehu Kahaliw. "Antidiarrheal Activity of Hydromethanolic Root Extract and Solvent Fractions of Clutia abyssinica Jaub. & Spach. (Euphorbiaceae) in Mice." Evidence-Based Complementary and Alternative Medicine 2020 (January 17, 2020): 1–9. http://dx.doi.org/10.1155/2020/5416749.

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Introduction. Diarrheal diseases are associated with an estimated 1.3 million deaths annually, with most occurring in resource-limited countries; up to 25% of deaths in young children living in Africa and southeast Asia are attributable to acute gastroenteritis. Due to limitations associated with various treatments available, the need for developing newer drugs is imperative. Objective. This study was aimed to evaluate the antidiarrheal activity of root extract and fractions of C. abyssinica Jaub. & Spach. (Euphorbiaceae) in mice. Methods. After plant extraction and subsequent fractionatio

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Eucharia Obioma Obiorah, Dorathy Chinwe Obu, Obumneme Benaiah Ezeanosike, Godwin Christian Akuodor, Chikere A Anusiem, and Anthonia Ugochi Okorie. "Ethanol leaf extract of Dialium guineense produces anti-diarrhoeal and gastrointestinal motility slowing activities in Wistar rats." Magna Scientia Advanced Research and Reviews 5, no. 1 (2022): 018–24. http://dx.doi.org/10.30574/msarr.2022.5.1.0088.

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Dialium guineense leaves have been traditionally used for the treatment of diarrhoeal diseases in Nigeria. The study was conducted to evaluate the anti-diarrhoeal and gastrointestinal motility slowing effects of the ethanol leaf extract of D. guineense in Wistar rats. The anti-diarrhoeal and gastrointestinal motility slowing effects of the ethanol leaf extract of D. guineense were evaluated using castor oil-induced diarrhoeal model, charcoal meal, and anti-enteropooling tests in Wistar rats. The test groups received various doses (100, 200, and 400 mg/kg) of the extract whereas positive contro

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Rahman, Md Khalilur, Md Ashraf Uddin Chowdhury, Mohammed Taufiqual Islam, Md Anisuzzaman Chowdhury, Muhammad Erfan Uddin, and Chandra Datta Sumi. "Evaluation of Antidiarrheal Activity of Methanolic Extract ofMaranta arundinaceaLinn. Leaves." Advances in Pharmacological Sciences 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/257057.

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Diarrhea is one of the most common causes for thousands of deaths every year. Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract ofMaranta arundinacealinn. (MEMA) leaves in rats and brine shrimp, respectively. Antidiarrheal effect was evaluated by using castor oil-induced diarrhea, enteropooling, and gastrointestinal motility tests at 200 mg/kg and 400 mg/kg body weight in rats where the cytotoxic activity was justified using brin

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Abdela, Jemal. "Evaluation of In Vivo Antidiarrheal Activities of Hydroalcoholic Leaf Extract of Dodonaea viscosa L.(Sapindaceae) in Swiss Albino Mice." Journal of Evidence-Based Integrative Medicine 24 (January 1, 2019): 2515690X1989195. http://dx.doi.org/10.1177/2515690x19891952.

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Traditionally people used Dodonaea viscosa for the treatment of various ailments, including diarrhea. Therefore, this study was aimed to evaluate the antidiarrheal activity of the 80% methanolic leaf extract of D viscosa against castor oil-induced diarrhea in mice models. Different doses of 80% methanolic leaf extract of D viscosa (100, 200, and 400 mg/kg) were evaluated for their antidiarrheal activities using castor oil–induced diarrhea, gastrointestinal transit, and enteropooling models in Swiss albino mice. At all test doses, the plant extract showed significant ( P < .05) inhibition in

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Michel, Archange Fokam Tagne, Aimé Noubissi Paul, Jeremie Teddine Tchoblaouna Keya, et al. "Effects of hydroethanolic extract of Cameroonian propolis (Promax-c) on castor oil-induced diarrhea in mice." World Journal of Advanced Research and Reviews 7, no. 3 (2020): 194–203. https://doi.org/10.5281/zenodo.4317683.

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The aim of our work was to evaluate the effect of hydroethanolic extract of Cameroonian propolis (Promax-c) on castor oil-induced diarrhea in mice. Diarrhea was induced in mice by oral administration 0.5 mL of castor oil in all mice. To determine the effective doses, each mouse received, 30 minutes after the administration of castor oil, one of the single oral doses of Promax-c: 0, 37.5, 75, 150, and 300 mg/kg bw. The mass and frequency of stool were measured and recorded per hour for five hours. The effect of Promax-c on the intestinal motility was evaluated by measuring the distance traveled

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Bogale, Achenef, Haile Alemayehu, Teshome Nedi, and Ephrem Engidawork. "Antidiarrheal and Antibacterial Activities of Calpurnia aurea: Benth Seed Different Extracts." Evidence-Based Complementary and Alternative Medicine 2022 (August 31, 2022): 1–12. http://dx.doi.org/10.1155/2022/9582687.

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Background. Calpurnia aurea is believed to have antidiarrheal potential but with limited scientific evidence. This study aimed investigating antidiarrheal and antibacterial activity of aqueous and 80% methanol seed extracts of the plant in mice and selected diarrhea-causing bacterial strains, respectively. Methods. Castor oil-induced diarrhea, prostaglandin-induced enteropooling, and castor oil-induced charcoal meal test models in mice of either sex using three dose levels (60, 120, and 240 mg/kg) were applied to evaluate antidiarrheal activity. Parameters, including onset, number, wet stool w

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Derebe, Dagninet, Mohammedbrhan Abdulwuhab, Muluken Wubetu, and Faiz Mohammed. "Investigation of the Antidiarrheal and Antimicrobial Activities of 80% Methanolic Leaf Extract of Discopodium Penninervum (Hochst.)." Evidence-Based Complementary and Alternative Medicine 2018 (October 4, 2018): 1–7. http://dx.doi.org/10.1155/2018/1360486.

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Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose. In Ethiopia, for instance, Discopodium Penninervum is used for the treatment of diarrhea and also to control infection. The aim of the present study was, therefore, to evaluate the in vivo antidiarrheal and in vitro antimicrobial effect of Discopodium Penninervu

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Noubissi, Paul Aimé, Adela Ngwewondo, Michel Archange Tagne Fokam, Gaëtan Olivier Fankem, and René Kamgang. "Spasmolytic and Anti-Secretory Activities of Water/Ethanol Crinum jagus Extract." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 5 (October 2016): 52–59. http://dx.doi.org/10.18052/www.scipress.com/ijppe.5.52.

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The present study was undertaken to determine the potential anti-secretory and spasmolytic mechanism ofCrinum jaguswater/ethanol extract (25, 50 and 100 mg/kg, po). Anti-secretory activities were evaluated using castor oil and PGE2-induced enteropooling models in rats. Spasmolytic activities were conducted on small intestinal transit, on carbachol, 5-HT-induced intestine motility as well as on naloxone-pretreated intestine transit.C.jagusextract 25, 50 and 100 mg/kg bw has significantly (p<0.01) reduced in dose-dependent manner the castor oil-induced intestine secretion with inhibition rate

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Anele, Donatus Onyebuchi, Godwin Christian Akuodor, Casmir Emeka Okoroama, et al. "Evaluation of Medicago sativa ethanol leaf extract for antidiarrheal activity in Wistar rats." GSC Biological and Pharmaceutical Sciences 26, no. 3 (2024): 159–69. https://doi.org/10.5281/zenodo.11044831.

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<strong>Aim:</strong> <em>Medicago sativa</em> leaf is traditionally used for the treatment of gastrointestinal disorders in Nigeria. This research investigates the <em>in vivo</em> antidiarrheal activity of <em>M. sativa</em> (Alfalfa) leaf extract in Wistar rats. <strong>Method:</strong> The study employed three models: castor oil-induced diarrhea, gastrointestinal motility (charcoal meal), and castor oil-induced intestinal fluid accumulation. The phytochemical analysis as well acute toxicity tests were carried out in the leaf extract. <strong>Results:</str

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Sanda, Kyari Abba, Umar Kyari Sandabe, Ibrahim Bulama, et al. "Phytochemistry and effects of Ethanol Leaf Extract of Meytenus senengalensis (Lam) on Castor-oil Induced Diarrhoea in Albino Rats." Sahel Journal of Veterinary Sciences 17, no. 1 (2020): 1–6. http://dx.doi.org/10.54058/saheljvs.v17i1.89.

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Abstract Meytenus senengalensis (Lam). Ethanol leaf extract was investigated for its phytochemical contents as well as anti-diarrhoea effects. The ethanol leaf extract which is normally used in folkloric medicine was subjected to qualitative phytochemical screening. Graded doses of the extract (200, 400 and 800 mg per kg) were administered orally to the three groups of rats (n = 5) before induction of diarrhoea with castor oil. Another two groups of animals were treated with normal saline (control) and loperamide, a conventional anti-diarrhoea drug respectively. Gastro-intestinal transit

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Fokam Tagne, Michel Archange, Hypolyte Akaou, Paul Aimé Noubissi, et al. "Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice." Gastroenterology Research and Practice 2019 (December 1, 2019): 1–8. http://dx.doi.org/10.1155/2019/6963548.

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Objective. The treatment of diarrheal diseases is a serious problem in developing countries, where population generally uses medicinal plants. The leaves of Bixa orellana have been reported to be traditionally used in the treatment of diarrhea by local people in the district of Khulna in Bangladesh. The aim of this study was to investigate the effects of the hydroethanolic extract of Bixa orellana leaves on castor oil-induced diarrhea in mice. Methods. The powder of the leaves of Bixa orellana was macerated in ethanol/water mixture (20/80) for 48 hours and then filtered. The filtrate obtained

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Perpetual, Ezeihuaku Amaka, Ejiofor InnocentMary Ifedibaluchukwu, Ajaghaku Daniel Lotanna, Ezugwu Christopher Obodike, and Ibe Chioma Ifeoma. "In-Vivo Antidiarrhoea Evaluations of Methanol Leaf Extract and Fractions of Chrysophyllum albidum." Scholars Academic Journal of Pharmacy 13, no. 01 (2024): 23–29. http://dx.doi.org/10.36347/sajp.2024.v13i01.003.

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Background and Objectives: In Nigeria, traditional use of medicinal plants, like Chrysophyllum albidum, for diarrhoea persists. This study assessed its effectiveness in treating diarrhoea in rats. Methods: Extract and Fractions from the plant were tested for antidiarrhoea effect. The process involved methanol extraction and fractionation using hexane, ethyl acetate, and butanol. Rat models were used to evaluate the effects on castor oil-induced diarrhoea, enteropooling, and gastrointestinal motility. Results: Defecation caused by castor oil-induced diarrhoea was inhibited significantly by 53.5

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Ashraf-ul, Kabir, Malrina D'Costa Ninadh, Bin Samad Mehdi, and Hannan JMA. "In vivo evaluation of antidiarrhoeal activity of ethanolic extract of leaf and bark of Ficus carica Linn." International Journal of Biomolecules and Biomedicine (IJBB) 2, no. 3 (2012): 1–7. https://doi.org/10.5281/zenodo.8288215.

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<em>Ficus carica</em> Linn is occasionally used in preparation of local traditional medicines used in the treatment of diarrhoea in Bangladesh. Our present studies make an attempt toward validating this traditional use by investigating antidiarrhoeal activity of F. carica Linn. Ethanolic extract of leaf and bark of F. carica Linn showed significant (p ≤ 0.05) decrease in the severity of diarrhoea, in a dose dependent manner, in castor oil induced diarrhoea test. Prostaglandin E2 induced intestinal fluid accumulation test (enteropooling) gave significant results (P ≤ 0.05), indicatin

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Ogechi O. Anyanwu, Chukwubuikem C. Okolo, Innocent N. Okpoli, and Festus B.C Okoye. "Evaluation of antidiarrheal properties of leaf extracts of Acioa barteri (Chrysobalanaceae) in Wister albino mice." Magna Scientia Advanced Biology and Pharmacy 9, no. 2 (2023): 090–97. http://dx.doi.org/10.30574/msabp.2023.9.2.0052.

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Diarrhea remains one of the most important health issues worldwide, with high morbidity and mortality rates, accounting for more than two million deaths annually. Oral rehydration therapy (ORT) is central to the management of diarrhea, and is sufficient to prevent complications due to dehydration in most patients while the disease runs its course. However, ORT has no effect on the duration of the disease or frequency of bowel motions, and any agent that could meet these needs would therefore be a useful addition to ORT. The aim of the study is to evaluate the antidiarrheal properties of the le

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Chima Ernest Orji, Nkemakonam Chinecherem Madu, Izunna Somadina Okwelogu, et al. "Anti-diarrheal effects of ethanol leaf extract of Eleusine Indica in Castor Oil induced diarrhea using mice model." Magna Scientia Advanced Biology and Pharmacy 12, no. 2 (2024): 011–22. http://dx.doi.org/10.30574/msabp.2024.12.2.0031.

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Ancient civilizations employed medicinal herbs to treat ailments. Medicinal herbs are essential for treating chronic disorders. Different medicinal plants can treat comparable ailments, depending on the country. In many rural communities in developing countries, particularly in Africa, therapeutic medicines and remedies derived from indigenous plants are almost invariably the only readily available and cost-effective alternatives to traditional diarrhea medicines. The study aims to evaluate the anti-diarrheal activity of the Eleusine indica ethanol extract in mice. The study used fresh Eleusin

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Douho Djimeli, R. C., M. L. Nchouwet, S. L. Poualeu Kamani, L. M. Tchoumba Tchoumi, A. Kamanyi, and S. L. Wansi Ngnokam. "Antisecretory and Spasmolytic Activities of Aqueous and Ethanolic Stem Bark Extracts of Nauclea diderrichii in Wistar Rats." BioMed Research International 2022 (June 19, 2022): 1–10. http://dx.doi.org/10.1155/2022/7569848.

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Background. Diarrheal diseases are a major cause of morbidity and mortality throughout the world and particularly in developing countries. Nauclea diderrichii is a plant used in traditional medicine in the treatment of anemia, fever, gastric ulcer, malaria, abdominal pain, skin infections, and diarrhea. The present work is aimed at evaluating the antisecretory and spasmolytic activities of aqueous and ethanolic stem bark extracts of Nauclea diderrichii in Wistar rats. Methods. The effect of aqueous and ethanolic extracts of Nauclea diderrichii was tested at doses of 100, 200, and 300 mg/kg on

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Mussarat, Sakina, Muhammad Adnan, Shaheen Begum, Alamgeer, Riaz Ullah, and Alicja Kowalczyk. "In Vivo Efficacy, Toxicity Assessment, and Elemental Analysis of Traditionally Used Polyherbal Recipe for Diarrhea." Evidence-Based Complementary and Alternative Medicine 2022 (August 22, 2022): 1–11. http://dx.doi.org/10.1155/2022/5977795.

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A polyherbal formulation consisting of Mentha piperita L., Camellia sinensis L. Kuntze, and Elettaria cardamomum (L.) Maton with a ratio of 10 : 5 : 2, respectively, was recommended for curing nausea, vomiting, and diarrhea. Experimental validation is crucial to affirm its therapeutic property leads toward the development of modified antidiarrheal agents. This research aimed to investigate the in vivo antidiarrheal efficacy of traditionally used polyherbal recipe in a castor oil-induced animal model. Moreover, the study also presents the elemental screening and in vivo toxicity of tested polyh

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Onoja, Samuel O., Ginika Q. Ihejirika, Oluchi N. Nwankudu, Yusuf N. Omeh, and Maxwell I. Ezeja. "Antidiarrheal and Antioxidant Activities of Methanol Extract of Bryophyllum pinnatum Leaf Harvested from South-Eastern Nigeria in Mice." Journal of Pharmaceutics 2018 (May 29, 2018): 1–6. http://dx.doi.org/10.1155/2018/6810620.

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Bryophyllum pinnatum belongs to the family Crassulaceae and it is commonly used in the ethnomedical practices. This study investigated the antidiarrheal and antioxidant properties of methanol extract of Bryophyllum pinnatum leaf harvested from South-Eastern Nigeria in mice. Cold maceration method in 80% methanol was adopted in the extract preparation. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to evaluate the antioxidant property while castor oil-induced diarrhea, small intestinal transit, and enteropooling models were used for the an

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