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Hébert, Jean-Pierre. "Paysage castral en Bessin et Pays d'Auge du XIVe au XVIe siècle." Paris 10, 2008. http://www.theses.fr/2008PA100125.
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Nous avons étudié les formes et les raisons sociales des implantations castrales en Bessin et Pays d'Auge dans un contexte géopolitique mouvementé. Après leur recensement sur le terrain, les édifices ont été classés en fonction des formes, des caractéristiques d'implantation et du niveau socioéconomique des commanditaires. Ces édifices, plutôt modestes, ont une architecture élaborée et un caractère ostentatoire manifeste. A partir de l'existant, avec une approche typologique, on a tenté de représenter le patrimoine d'origine en tenant compte des destructions de la Guerre de Cent Ans et des autres conflits. L'influence du contexte géographique (substrats, paysages et climat) sur la répartition des édifices a été démontrée et un lien entre implantation castrale et activités agricoles, a été établi. Le contexte historique régional a été rappelé avec l'occupation anglaise au XVe siècle. Le particularisme normand et le contexte socio-économique régional récessif ont impacté les implantations troublées par les combats, famines et épidémies. Le quasi monopole de la noblesse dans les seigneuries va se morceler avec l'arrivée des bourgeois enrichis qui vont être en grande partie responsables de la floraison d'édifices observée après la période de conflit. Nous avons détaillé l'apport des nouvelles techniques de construction, les choix de matériaux, la présence d'espaces privilégiés comme la chambre-haute, le décor et le confort de la résidence. Une nouvelle forme d'habitation va émerger dès la première moitié du XVe siècle en référence à un modèle privilégié, la "maison à étage" avec de nouveaux goûts pour les décors et, la défense vue surtout comme un symbole du statut social<br>In a various geopolitical context, we studied the architecture and the social reasons of the castles in Bessin and Pays d'Auge. After their inventory, we listed them according to the forms, the characteristics of the establishment and the socio-economic level of the sleeping partners. These buildings, despite their ostentatious features, were not that huge. From what exists, with a typological approach, we tried to represent the cultural heritage by taking account of the destruction of the One Hundred Years war and other conflicts. We notice that the settings up of castles were linked to geographic situation (landscapes, climates…) and the agricultural activities. We also observed that the English occupation, the famines, the battles, the epidemics and the socio-economic context, in the XVth century, have highly influenced the construction. Almost monopoly of the nobility in the seigneuries is going to split with the arrival of the enriched middle-class persons who are going to be responsible largely of the burgeoning of buildings observed after the period of conflict. We detailed the contribution of the new techniques of construction, the choices of materials, the presence of privileged rooms like “the upper chamber”, the decoration and the comfort of the residence. A new shape of house is going to appear from the first half of the XVth century in reference to a privileged model, the "house with floor" with new tastes for decorations and, the defence equipment sight especially as a symbol of the social status
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Kersuzan, Alain. "Le Réseau castral savoyard de Bresse et de Bugey pendant la guerre delphino-savoyarde : 1282-1355." Chambéry, 2002. http://www.theses.fr/2002CHAML016.
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La thèse met en évidence le fonctionnement d'une organisation castrale centralisée et participant activement à la construction de la principauté savoyarde et à son implantation territoriale. L'introduction contient l'état des sources et une bibliographie de 16 pages. La première partie circonscrit le cadre politique et spatial, puis retrace les événements militaires. Des cartes permettent de suivre les évolutions. La deuxième partie traite du réseau castral en en soulignant la logique, sa structure et son évolution. La troisième partie traite de la typologie des fortifications, de l'organisation des différents éléments défensifs et résidentiels. La quatrième partie étudie l'organisation des chantiers, l'origine et la mise en oeuvre des matériaux, le coût des constructions. Un volume d'annexes aborde l'étude monographique des châteaux, des tableaux comparatifs des dépenses pour les constructions et la guerre, des transcriptions de comptes, un glossaire.
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Cassan, Élodie. "Le bourg castral de Najac au Moyen âge : formation et évolution d'un paysage urbain en Rouergue occidental /." [Villefranche-de-Rouergue] (Musée Urbain-Cabrol, Pl. de la Fontaine, 12200) : Société des amis de Villefranche et du Bas-Rouergue, 2006. http://catalogue.bnf.fr/ark:/12148/cb40972843f.
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Muller, Vianney. "Le patrimoine fortifié du lignage de Neufchâtel-Bourgogne (XIIIe-XVIe siècles)." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0130/document.
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Les familles seigneuriales n’ont que rarement servi de cadre à l’étude du phénomène castral. Le lignage de Neufchâtel-Bourgogne présente un double d’intérêt. D’une part, son ascension sociale est très marquée entre le XIIIe et le XVIe siècle, d’autre part son patrimoine castral, composé de 37 châteaux, est disséminé sur plusieurs principautés, du comté de Bourgogne au duché de Luxembourg. La démarche historique permet de décrypter le jeu des stratégies territoriales de la famille et de dégager les structures de la gestion de la démographie familiale. L’approche en archéologie du bâti offre un regard renouvelé qui permet parfois de préciser le rôle de la famille dans la construction ou l’aménagement de ses châteaux. La réunion des deux méthodes permette une meilleure compréhension des fonctions assurées par le château (résidence, défense, administration, pôle économique et symbolique) et leur évolution. Elle permet enfin de saisir le fonctionnement quotidien d’un réseau castral seigneurial où les échanges s’affranchissent des limites des principautés<br>The seigneurial families are rarely a framework for reflection of the castral phenomenon. The Neufchatel-Burgundy’s lineage is particularly interesting for two reasons. Firstly, for its social rise between the 13th and 16th centuries and secondly, for its 37 castles which are settled through several medieval principalities, from County of Burgundy to the Duchy of Luxembourg. The historical approach allows to decrypt the territorial strategy and the adaptability to manage his familial demography. The archeology of architecture shows family’s role into construction and development of its castles. Both of these methods help for comprehension of the functions of the castles (residence, defense, administration, economy and influence) and their evolutions. Finally, it shows the mechanisms of a castral network and how exchanges between castles can overcome the borders of the principalities
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Casaubon, Anaïs. "Le château de Pouancé (Maine et Loire) : évolution d'un site castral des marches de Bretagne (XIIIe-XVe siècle)." Nantes, 2012. http://www.theses.fr/2012NANT3049.
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Site fortifié de premier plan en Anjou, le château de Pouancé est caractérisé par la variété et la relative bonne conservation de ses formes architecturales. Celles-ci permettent d'appréhender l'évolution d'un site castral, en particulier pour la fin du Moyen-Age, les témoins du XVe siècle étant les plus nombreux. La situation géopolitique dans laquelle il évolue durant toute la période médiévale renforce son intérêt scientifique : les marches de Bretagne sont une zone frontière qui, en tant que telle, a cristallisé dans le bâti les nombreux conflits qui ont opposé le royaume de France au duché Bretagne. Ce site est donc un support tout désigné pour comprendre les différentes dynamiques qui le traversent, en particulier celles qui sont en lien avec l'apparition et le développement de l'artillerie à poudre à partir du XVe siècle. Les méthodes employées par l'archéologie du bâti sont appliqués afin d'aboutir à une compréhension des articulations internes du château et de ses phases successives. Cette première lecture est combinée à la comparaison du bâti en place avec d'autres formes architecturales, sélectionnées selon des échelles géographiques variables. Cette approche doit permettre, outre la proposition d'un phasage global précis inédit, d'appréhender les différents phénomènes liés à un site castral. Comment habite-t'on et surtout, comment se défend-on, en particulier à la fin du Moyen Age, dans un contexte local marqué par les conflit répétés ? Et au-delà des simples références aux fonctions défensives et résidentielles, la réflexion menée permet d'approfondir notre compréhension des rôles successifs du château et de sa perception, au sein de la société médiévale.
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Leroux, Estelle. "Les usages des châteaux forts urbains en Bourgogne à l'époque moderne." Phd thesis, Université de Bourgogne, 2011. http://tel.archives-ouvertes.fr/tel-00685493.
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Etudier les forteresses des villes de Bourgogne signifie s'intéresser aux rapports entre, d'une part, ces bâtiments et leurs occupants et, d'autre part, la société dans laquelle ils sont implantés. Une ville avec un château fort n'est pas toujours un bourg castral. Le château peut engendrer, déplacer, ou dynamiser une agglomération. Sa représentation traduit également la place qu'il occupe dans la société. La genèse de la cité a souvent des conséquences tout au long de l'époque moderne sur les relations entre le château et la ville. Dans la guerre, le château peut représenter la ruine ou le salut pour la ville. Dans la paix, c'est le plus souvent un poids mort : il faut l'entretenir, parfois aussi entretenir la garnison. Mais dans la dialectique villes/châteaux, les premières sont largement gagnantes aux XVIIe et XVIIIe s., ce qui se concrétise par des réaffectations, des abandons, ou le plus souvent des destructions des forteresses urbaines.
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Pauthier, Philippe. "Chasse, pêche, élevage et alimentation : archéozoologie des marges occidentales du Saint-Empire romain germanique, et orientales du Royaume de France." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUL015.
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Mon travail explore les relations entre l'homme et l'animal, de la période médiévale à la période moderne, par l'analyse des restes osseux dans l'Est de la France, en contexte castral et urbain. Ce travail repose sur l'analyse de plus de 90.000 restes osseux d'animaux retrouvés sur les sites archéologiques. Ces vestiges proviennent de mammifères, d'oiseaux et de poissons.Le but de mes recherches est avant tout de dresser un tableau de l'alimentation carnée des franges aisées de la population - noblesse castrale ou riches bourgeois. Les grandes thématiques concernent l'histoire de la boucherie, les techniques de traitement des viandes, des poissons, les choix et interdits culinaires, l'approvisionnement des villes et la caractérisation sociale par les pratiques alimentaires. Interviennent aussi les possessions d'animaux en tant que bien luxueux tels les chiens constituant une meute de chasse, ou l'importation d'animaux exotiques.Ces analyses permettent également de mieux comprendre la spécialisation de chaque site, et de comparer ces sites entre eux pour une réflexion à l'échelle régionale. Les résultats archéozoologiques sont confrontés au contexte archéologique dans lequel ils ont été découverts. L'analyse des spectres fauniques obtenus permet d'observer les distinctions sociales au travers de l'alimentation, ainsi que leur évolution. Se poser des questions sur ces écarts au cours du temps, c'est aussi vérifier la pérennité de ces classes sociales privilégiées<br>My work explores the relationships between man and animal, from the medieval period to the modern period, through the analysis of skeletal remains in Eastern France, in a castral and urban context. This work is based on the analysis of more than 90,000 animal bone remains found on archaeological sites. These remains come from mammals, birds and fish.The aim of my research is above all to draw up a picture of the meat diet of the wealthy sections of the population - the castral nobility or the rich bourgeoisie. The main themes concern the history of butchery, the techniques for processing meat and fish, culinary choices and prohibitions, supplying cities and social characterization through food practices. Possessions of animals as luxury goods, such as dogs constituting a hunting pack, or the importation of exotic animals, also come into play.These analyzes also make it possible to better understand the specialization of each site, and to compare these sites with each other for reflection on a regional scale. The zooarchaeological results are compared with the archaeological context in which they were discovered. The analysis of the faunal spectra obtained makes it possible to observe social distinctions through diet, as well as their evolution. Asking questions about these gaps over time also means checking the sustainability of these privileged social classes
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Jeangrand, Estelle. "Les usages des châteaux forts urbains en Bourgogne à l'époque moderne." Thesis, Dijon, 2011. http://www.theses.fr/2011DIJOL024/document.
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Etudier les forteresses des villes de Bourgogne signifie s’intéresser aux rapports entre, d’une part, ces bâtiments et leurs occupants et, d’autre part, la société dans laquelle ils sont implantés. Une ville avec un château fort n’est pas toujours un bourg castral. Le château peut engendrer, déplacer, ou dynamiser une agglomération. Sa représentation traduit également la place qu’il occupe dans la société. La genèse de la cité a souvent des conséquences tout au long de l’époque moderne sur les relations entre le château et la ville. Dans la guerre, le château peut représenter la ruine ou le salut pour la ville. Dans la paix, c’est le plus souvent un poids mort : il faut l’entretenir, parfois aussi entretenir la garnison. Mais dans la dialectique villes/châteaux, les premières sont largement gagnantes aux XVIIe et XVIIIe s., ce qui se concrétise par des réaffectations, des abandons, ou le plus souvent des destructions des forteresses urbaines<br>Study the urban fortresses of Burgundy means interesting in the relationships between, on the one hand, these buildings and their occupants and, on the other hand, the society in which they are located. A city with a castle isn’t necessarily a castral town. The castle can generate, move or expand a city. Its representation also reflects its place in society. The genesis of the city often has consequences throughout the modern times on relationships between the castle and the city. In wartime, the castle can be the ruin or the salvation for the city. In peacetime, it’s most often a dead weight : it must be maintained, sometimes its garnison must be maintained too. But in the dialectic cities/castles, the second ones are heavily defeated, which takes the form of redeployments, abandonments, or more often destructions of urban castles
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Bosch, Casadevall Josep Maria. "L’escenari del feudalisme a la frontera del comtat de Barcelona. Anàlisi territorial dels assentaments, l’espai obert i els camins del terme castral d’Olèrdola (segles X -XI)." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/525826.
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Avui dia el debat historiogràfic sobre la formació del feudalisme a Catalunya bascula entre el model rupturista de Pierre Bonnassie i el model continuista de Gaspar Feliu. El nivell de coneixements actual no permet encara posicionar-se clarament en un sentit o en un altre. Així, doncs, es continua acceptant, no sense matisos, que a les terres de la frontera del comtat de Barcelona, després d’una tendència depressiva multisecular, tot canvia quan al segle X esdevé un territori cobejat per les elits comtals. En relació amb aquest desig de posseir la terra, aquesta tesi explora a petita escala les decisions preses l’endemà de la conquesta a l’hora de determinar la mida dels termes castrals, d’ executar l’atermenament del sòl, de seleccionar el tipus de sòl atermenat i de triar el nombre d’assentaments per terme, així com les constants d’implantació dels castells i de les esglésies. L’objectiu d’aquesta anàlisi és conèixer el tipus d’ articulació que es produeix, d’una banda entre les preexistències del territori, i els castells i les esglésies de l ’altra. En altres paraules, es pretenen aconseguir proves de fins a quin punt aquestes decisions són fruit només de l’atzar o si bé ja estan determinades. És a dir, condicionades només per una manera de fer gravada en el subconscient en forma d’idees tipus que s’adapten als condicionants del territori, o bé de models que s’apliquen independentment d’aquests condicionants. En definitiva, aquesta tesi aspira a precisar la naturalesa de l’escenari en el qual les elits comtals imposen un nou ordre social i polític per a garantir continuar canalitzant les rendes de la terra.<br>Nowadays the historiographical debate on the formation of feudalism in Catalonia fluctuates between the Pierre Bonnassie’s breaking model and Gaspar Feliu’s continuity model. The present level of knowledge does not yet allow for a clear positioning one way or another. Thus, we still accept, not without nuances, that everything changes when, in the 10th Century, the county of Barcelona borderland, after several centuries of depressive tendency, becomes a land coveted by count elites. Related to the desire to own the land, this thesis explores in its own small scale the decisions made the day after the conquest in determining the size of castral boundaries, the execution of land demarcation, the selection of the type of bordered land and the choice of the number of settlements per boundary, as well as the constants of introduction of castles and churches. The aim of this analysis is to find out the kind of relationship that occurs on the one hand between the pre- existing ones in the land, and castles and churches on the other hand. In other words, the goal is to obtain evidence about the extent to which these decisions are the result of simple chance or if they have already been determined, that is to say, conditioned only by behaviours engraved in the subconscious under the form of archetypal ideas adapted to the territory conditions, or else models that are applied regardless of these conditions. In short, this thesis aims to clarify the nature of the scenario in which count elites impose a new social and political order to ensure their continued channelled income from the land revenues.
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Aumasson, Ludovic. "Chassingrimont : de la maison-forte au chastel : étude d'un site castral sur les confins du Berry et du Poitou, de la fin du Moyen âge à l'époque moderne /." Châteauroux (90 Av. F. Mitterrand, 36000) : CREDI éd, 2008. http://catalogue.bnf.fr/ark:/12148/cb41275415r.
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Sun, Jessica. "The Baroque Orpheus: Fragmentation and metamorphosis in the age of the operatic castrato." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/16863.
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This thesis is a study in the imagery of bodily fragmentation and metamorphosis in Baroque opera culture from the early seventeenth to the mid-eighteenth century. It seeks to bring together the thematic narratives of the opera seria genre with the status of its singers, the attitudes of its audiences, and contemporary notions about the voice, the body, anatomy, masculinity and sexuality. I have taken for this study's leitmotif the disembodied head of Orpheus -as a symbol of mutilation, metamorphosis, uncanniness, artistic legacy, and transcendence, but also for its parallel with the mutilated body of Baroque opera's castrato singer. Just as the singing head of Orpheus seems to defy the relationship between body and voice, so too does the powerful, otherworldly voice of the singer seem to belie its inextricably causal relationship with his mutilated body. This project hopes to show how these two fragmentary singers -Orpheus and the castrato - were received and regarded in various locales throughout Europe, and how these implicit parallels manifested, onstage or otherwise, in different ways: in the theatrical culture of Venice, where its comic opera and commedia dell'arte tradition casts a light on different forms of physical distinctiveness; the parallels between the dismemberment of Orpheus, the "sacrificial" mutilation of the singer and the wounds of Christ in the sacred context of Baroque Rome; and the satires of the exotic spectacle ofltalian opera in early eighteenth century London, in which critical commentators metamorphose its singers from male to female, animal to monster. In all these settings, the reception of opera and of its singers also forms part of each culture's relationship with antiquity and the classical artistic legacy. Ultimately, this study uses the spreading culture of opera within its chosen timeframe to explore the Baroque era's attitudes towards wholeness and fragmentation, and the role that ''metamorphosis" (Ovidian, figurative, metaphorical) might play in the relationship between nature and culture in the Baroque imagination.
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Paloumbas, Dimitri. "Du castrum à la maison : villages castraux et habitats en vicomté de Turenne (Xe siècle-milieu du XIVe siècle)." Thesis, Toulouse 2, 2011. http://www.theses.fr/2011TOU20114.
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Estienne, Marie-Pierre. "Les réseaux castraux et l'évolution de l'architecture castrale dans les Baronnies de Mevouillon et de Montauban de la fin du Xe siecle à 1317." Aix-Marseille 1, 1999. http://www.theses.fr/1999AIX10077.
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Entre Provence et dauphine, l'enracinement dès le XIe s. D'une famille seigneuriale, géographie historique d'une étude portant sur l'enchatellement, dans une zone de moyenne montagne appelée les baronnies, terre bénéficiant de l'immunité impériale jusqu'en 1317. La recherche des origines de cette lignée au Xe s. Permet de dresser, le tableau de la répartition des alleux, et d'inscrire l'histoire de la constitution de leur domaine dans un cadre géographique plus large, de la rive droite du Rhône à la rive gauche de la Durance. Lies a l'archevêque d’Arles par les contrats de précaires au Xe s. , les membres de cette famille, issus de l'aristocratie carolingienne, sont dès le XIe s. , des proches des comtes de Forcalquier et de Provence ; ils participent, sur les marges occidentales de leur territoire, a la croisade albigeoise. Leur domaine rassemble au XIIIe s. 178 alleux dont la majeure partie sont des castra (171). Si une première vague de création de châteaux est très nettement sensible dès la première moitié du XIe s. Le développement s'accélère très nettement à la fin du XIIe et dans la première moitié du XIIIe s. Succédant aux premiers castra (plateaux rocheux ou mottes), les vestiges de 25 donjons romans conserves, témoignent encore de cette période d'apogée. 84 % des châteaux ont en effet génère la présence d'un bourg castrai dont 50 % abrite une église paroissiale intra-muros. Cette dernière est parfois concurrencée par des prieures séculiers, fondes dès le haut moyen-âge. Les baronnies ont des affinités évidentes avec le comte de Provence, en matière de réussite de l'enchatellement. Il en diffère cependant par un décalage chronologique légèrement plus tardif, a l'exemple du phénomène castrai varois ou encore de celui de la Gascogne. Les influences septentrionales sont très mitigées en raison d'une annexion tardive des baronnies par le dauphin, préoccupe par la constitution progressive de son domaine, mais qui aura raison de l'indépendance des baronnies, annexées par ce dernier en 1317. Endettement et absence de postérité amorcent un processus de désertion du castrum, et de désertification de cette région au XVe s.
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Ramos-Murga, Flórez Christofer, Miguel Ángel Revatta, Fernando Revatta, Elena Moscol, and Jeniffer Ramos-Murga. "Edificio multifamiliar: las terrazas de Castrat." Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2009. http://hdl.handle.net/10757/273962.
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El sector de la construcción ha experimentado en los últimos años una crecida, gracias a programas promotores del gobierno como Mi Vivienda o Techo propio. Dentro del mercado de construcción, nace una nueva oportunidad como es el método de autoconstrucción. Actualmente, se cuenta con el know how del Negocio y se puede aplicar fácilmente en el mercado limeño, poniendo precios competitivos sin afectar la calidad que permita tener una diferencia con la competencia.
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Fern, Terry L. (Terry Lee). "Adaptation of Handel's Castrato Airs for Bass: A Lecture Recital, Together with Three Recitals of Selected Works of J.S. Bach, W. Mozart, M. Ravel, G. Finzi, R. Schumann, A. Caldara, G. Handel, H. Wolf, H. Duparc, C. Ives and S. Barber and an Operatic Role by Verdi." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc332021/.
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The lecture recital was given on April 18, 1977. The subject was Adaptation of Handel's Castrato Airs for Bass, and it included a discussion of conventions peculiar to Handelian opera seria, concerns regarding adaptation of Handel's castrato airs and a comparison of adaptation practices in eighteenth- and twentieth-century presentations of Handel's operas. Three coloratura castrato airs and two virtuoso bass airs were performed at the conclusion of the lecture.
In addition to the lecture recital, one operatic role and three recitals of solo literature for voice, piano and chamber ensemble were publicly performed. These included the role of "Samuele" in A Masked Ball, by Verdi, performed in English on March 19, 1975 with the Opera Theatre of North Texas State University, a program presented on November 24, 1975,of solo literature for voice, piano, and chamber ensemble, including works by J. S. Bach, W. Mozart, M. Ravel and G. Finzi, a program consisting of a set of works by R. Schumann presented on June 27, 1985, and a program presented on October 28, 1985,of solo literature for voice, piano, and chamber ensemble,including works by A. Caldara, G. Handel, H. Wolf, H. Duparc, C. Ives and S. Barber.
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Kouba, Lina. "Castrer avant de se faire castrer : relation névrotique entre père et fils." Paris 13, 2011. http://scbd-sto.univ-paris13.fr/secure/ederasme_th_2011_kouba.pdf.
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Bernard avait une image de perdant de lui – même. Il a commencé à refuser toute interaction avec la famille et la société. Il s’isolait. Il doutait de son identité sexuelle. Il a fait une dépression. De la vérité. Il s’est réfugié au couvent. Il est devenu psychosomatique. Amine, de peur de masculinité excessive et agressive, a trouvé refuge dans la féminité, ses réactions incontrôlables l’ont conduit en prison. Il est devenu délinquant. Ces trois personnes sont des jeunes gens qui souffrent dune relation névrotique, angoissante et qui cachent plusieurs sentiments ambivalents avec leur père. Mais, les pères, aussi, ont une histoire intéressante avec leur propre père et ainsi de suite, d’une génération à l’autre la problématique s’amplifie. La relation père / fils est une relation ambivalente : rapport de force, de rivalité, d’agressivité, de peur, d’angoisse et en même temps d’amour, de fierté et de soutien. Que cache cette giboulée de sentiments très forts, et en même temps très expressifs ? Cache-telle une relation névrotique perverse et incestueuse ? Pourquoi le père a-t-il peur de son fils spécialement de l’aîné ? Aussi, pourquoi le fils veut- il battre le père, qui est pour lui le bien aimé ? En quoi consiste cet enjeu de castration entre les deux ? Est-ce une problématique qui se transmet d’une génération à une autre ?si oui, sous quelle forme ?et comment cela se transmet – il ?<br>Bernard had an image of himself as a loser. He started refusing any interaction with the family and the society. He isolated himself, and had doubts about his sexual identity. He suffered from a depression. Karl devoted his youth to trying to find the Father and the truth. He took refuge in a monastery. He became psychosomatic. Amine, for fear of excessive and aggressive masculinity, hid behind femininity. His uncontrollable reactions lead him to prison. He became an offender. The three are young people who suffer from neurotic, harrowing relations, and hide several ambivalent feelings towards their fathers. But the fathers themselves have an interesting story with their fathers too and so on, from a generation to another the issue develops and gets worse. The relation father-son is an ambivalent one: a relation of force, rivalry, pride and support. What does this shower of very strong, yet very expressive feelings hide? Does it hide a perverted neurotic and incestuous relationship ? Why does the father fear his son especially his eldest? Also, why does the son want to beat his father who is for him the beloved ? What does this castration issue consist of ? Is this an issue that is passed from a generation to another ? If yes, in which form ? And how is this passed on?
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Ekstrum, Dave. "Naples and the Emergence of the Tenor as Hero in Italian Serious Opera." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1157563/.
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The dwindling supply of castrati created a crisis in the opera world in the early 19th century. Castrati had dominated opera seria throughout the 18th century, but by the early 1800s their numbers were in decline. Impresarios and composers explored two voice types as substitutes for the castrato in male leading roles in serious operas: the contralto and the tenor. The study includes data from 242 serious operas that premiered in Italy between 1800 and 1840, noting the casting of the male leading role for each opera. At least 67 roles were created for contraltos as male heroes between 1800 and 1834. More roles were created for tenors in that period (at least 105), but until 1825 there is no clear preference for tenors over contraltos except in Naples. The Neapolitan preference for tenors is most likely due to the influence of Bourbon Kings who sought to bring Enlightenment values to Naples. After the last castrato retired in 1830 and the casting of contraltos as male heroic leads falls out of favor by the mid-1830s, the tenor, aided by a new chest-voice dominant style of singing, becomes the inheritor of the castrato's former role as leading man in serious Italian opera.
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Caycho, Cesar. "Clase Maestra Faber-Castell." Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/656819.
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Desuó, Ivan Cesar [UNESP]. "Variação morfofisiológica das castas da vespa enxameante neotropical Polybia (Trichothorax) ignobilis durante sua ontogenia colonial (Hymenoptera, Vespidae, Epiponini)." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/99555.
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desuo_ic_me_rcla.pdf: 959937 bytes, checksum: d107c29f203623584bfa1329d44dc149 (MD5)<br>Universidade Estadual Paulista (UNESP)<br>A família Vespidae é um grupo chave para o entendimento da origem do comportamento social nos Hymenoptera, pois inclui desde espécies solitárias que não apresentam qualquer grau de socialidade até espécies que são altamente sociais como os Epiponini (Hymenoptera:Vespidae). A separação em castas é uma das pedras fundamentais da evolução dos insetos sociais, pois a presença de uma grande diferenciação entre as castas indica um maior grau de socialidade. Neste contexto, as vespas neotropicais pertencentes à tribo Epiponini despertam grande interesse em estudos de evolução de castas, pois além de apresentarem colônias poligínicas pode se observar um grande espectro de variação ocorrendo desde espécies com castas morfologicamente incipientes até distintas. Além disso, para uma dada espécie, o perfil de diferenciação morfológica entre as castas pode variar ao longo do ciclo colonial, evidenciando uma grande flexibilidade adaptativa frente às diferentes situações enfrentadas pela colônia ao longo de seu desenvolvimento. Diferenças morfofisiológicas entre as castas de 6 colônias em diferentes fases do desenvolvimento colonial de Polybia (Trychothorax) ignobilis foram analisadas. Para determinar as diferenças morfológicas entre as castas, foram medidas 13 varíaveis corporais externas provenientes da cabeça, mesossoma, metassoma e asa. Os ovários foram fotografados e esquematizados, a inseminação, idade relativa, a quantidade de tecido gorduroso e a condição morfológica da glândula de Richards foram analisadas. As fêmeas apresentaram uma seqüência gradual no padrão de desenvolvimento ovariano, desde ovaríolos...<br>The Vespidae family is a key group in evolutionary studies of sociality in Hymenoptera due to the occurrence of every step of social organization including species whose do not present any degree of sociality until those which are highly social, such as the Epiponini (Hymenopter: Vespidae). The separation into castes is one of the most important features of social insects and the presence of a higher level of caste differentiation indicates a well defined reproductive division of labor and consequently a higher degree of sociality. Morphological studies of caste differentiation in Neotropical social wasps concentrate mainly in the Epiponini tribe, once it’s ecologically abundant in Neotropics and presents a wide spectrum of variability of caste systems ranging from species with a slightly caste differentiation to those with conspicuous body differences. Besides, patterns of caste differentiation may vary according the colony cycle mainly in response to environmental changes which may affect the colony dynamics. Morphological and physiological differences between castes of 6 colonies of Polybia (Trychothorax) ignobilis were analyzed. Measurements were taken from 13 morphometric variables regarding the head, metasoma, mesosoma and wing... (Complete abstract click electronic access below)
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Sowle, Jennifer. "The castrato sacrifice was it justified /." Thesis, connect to online resource, 2006. http://www.unt.edu/etd/all/August2006/Open/sowle_jennifer_ruth/index.htm.
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Pinto, Elisabete Alves. "Vila de Castro." reponame:Repositório Institucional da UFPR, 2012. http://hdl.handle.net/1884/28942.
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Vafadar, Bahador. "Castrix : Utveckling av webbsidan Sundsvall42." Thesis, Mittuniversitetet, Institutionen för informationsteknologi och medier, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-16884.
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The goal of this Bachelor project was to develop the Sundsvall42 website,whose name originates from the conference held in week 42 and during whichall the IT-companies in Sundsvall gather and hold a number of different lectures.The website has been designed to accommodate both speakers and partipicants.All partipicants and lecturers will receive a personalized page inwhich there are a number of functions which are available for use, including ablog for each workshop and a calendar. The program used to create this isLiferay and the operating system is Linux. The entire website is encoded usingLiferay and Java, but the website is not adapted for use with the smaller screensize of the Smartphone. However, because of the Responsive Design technology,the website is able to adapt to various devices such as the Ipad and Smartphonesand the website will be able to adapt to the screen sizes of these devices.As it has all been processed using open-source, everyone has the right to accessthe source code. It is also possible for anyone to make changes to the code ifsuch changes are required. It is very important that two solutions are chosen asit is possible that one of the solutions will not prove to work adequately. Theconclusion was between the solutions given by both Liferay and HTML in ResponsiveDesign and it was determined that Liferay's version of ResponsiveDesign works better in its own environment.
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Mattant, de Biliotti Patrice. "Les castrats, essais d'histoire sociale." Paris 4, 1997. http://www.theses.fr/1997PA040167.
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Au contraire des peuples de l'antiquité qui pratiquèrent l'émasculation de leurs esclaves pour garder leur gynécée ou pour des plaisirs licencieux, la société européenne de l'époque moderne n'usa généralement de la castration que pour trois fins : thérapeutique, ascétique et euphonique. L'ablation des testicules, employée comme thérapie depuis les observations d'Hippocrate, continua jusqu'à la fin du XVIIIe siècle à être utilisée pour soigner de nombreuses maladies. Hors de cet usage médical, la jurisprudence civile et canonique condamnait tout autre pratique de cette mutilation. Pourtant, si les sociétés civiles et religieuses reprouvaient et pénalisaient les chrétiens qui confondaient ascétisme volontaire et castration, elles allaient tolérer l'émasculation euphonique de milliers d'enfants voire même, pour des théologiens de l'église catholique, démontrer la licéité de cette mutilation pour la gloire de dieu puis de la communauté. L'usage de la castration à des fins euphoniques fut découvert, semble-t-il, dans les pays ibériques lors de la Reconquista. Les premiers chantres castrats apparurent en Italie dans les années 1550-1560 et remplacèrent rapidement dans les églises de la péninsule et les chapelles de cour les falsettistes et les enfants guettés par la mue qui interprétaient les parties de soprani à la place des femmes interdites de chanter dans les lieux de culte. Ils furent aussi les virtuoses talentueux et renommés de la musique séculière pendant plus de deux siècles dans tous les pays européens. Si la majorité des castrations se pratiqua en Italie, d'autres pays émasculèrent aussi des enfants. Garçons de familles pauvres, les parents virent en cette opération la possibilité d'un emploi nourricier, clerc ou séculier, qui apporterait, après une formation dans un conservatoire réputé, sécurité voire richesse. La philosophie des Lumières relayée en Europe par la révolution française semble être une des raisons de la désaffection du public pour ces chanteurs<br>Unlike the people of antiquity, who emasculated their slaves to protect their women or for licentious pleasures, European society in the modern era used castration generally only for three purposes: as a therapy, for ascetic reasons, and for euphony. Ablation of the testicles, used as a therapy since the observations of Hippocrates, continued to be employed as a treatment for many diseases until the end of the 18th century. This medical use aside, civil and canon law condemned all other uses of the practice. Although civil and religious society censured and disciplined Christians who confused voluntary asceticism and castration, they did tolerate the emasculation of thousands of children for reasons of euphony. Theologians of the Catholic Church went so far as to demonstrate the licit nature of this mutilation, for the glory of god and of the community. The use of castration for reasons of euphony was discovered, it would appear, in the countries of Iberian Peninsula at the time of the Reconquista. The first castrati singers appeared in Italy in 1550-1560. In churches throughout Italy and in court chapels, they soon replaced falsetto singers and children, who were prone to having their voices change -two groups who used to sing the soprano line in the place of women, who were not allowed to sing where religious services were held. The castrati were also talented and renowned virtuosi of secular music for more than two centuries in all the countries of Europe. Although most castrations where performed in Italy, other countries emasculated children too. The children of poor families, either clerical or secular, these singers would earn security or even wealth, after receiving training at a renowned conservatory. The philosophy of the enlightenment, spread throughout Europe by the French revolution, seems to be one of the reasons for the public's disaffection with these singers
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Castel, Franck Atalla Noureddine Sgard Franck. "Modélisation numérique de matériaux poreux hétérogènes application à l'absorption basse fréquence /." Villeurbanne : Doc'INSA, 2006. http://docinsa.insa-lyon.fr/these/pont.php?id=castel.
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Thèse doctorat : Acoustique : Villeurbanne, INSA : 2005. Thèse doctorat : Acoustique : Université de Sherbrooke (Canada) : 2005.<br>Thèse soutenue en co-tutelle. Titre provenant de l'écran-titre. Bibliogr. p. 197-202.
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Gilgenkrantz, Claire. "L'espace faubourien : territorialisation des enjeux et acteurs locaux, l'exemple de castres (tarn)." Toulouse 2, 1990. http://www.theses.fr/1990TOU20030.
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A travers l'exemple de castres, ville moyenne situee au sud-ouest de la france, les faubourgs sont etudies sous differents aspects urbains, sociaux, economiques. Trois axes de recherche sont abordes : - la definition spatiale des faubourgs grace a une etude de la croissance urbaine locale ; - la socialite au quotidien des faubourgs, theme ayant fait l'objet d'une enquete aupres des habitants ; - la place des acteurs economiques des faubourgs par rapport a l'ensemble des acteurs locaux. Ces resultats mettent en lumiere l'importance des faubourgs dans le developpement social urbain et notamment le role qu'ls exercent sur l'avenir du centre ville<br>By castres's exemple, a middle town of france (s. O. ), this study tried to find out the suburban's stakes for next years. Three points have ben studied : - the suburban's definition in space by looking for the urban growth from time to time ; - how people who live there, perceive their neighbowrhood by asking them on place ; - what are the economic activities and the weight they carry on to the entire communal context. Thus, the suburban's part can be evoked with regard to the whole town and specially to the city's center
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Fritz, Hans. "Kastratengesang : hormonelle, konstitutionelle und pädagogische Aspekte /." Tutzing : H. Schneider, 1994. http://catalogue.bnf.fr/ark:/12148/cb357192424.
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Warynski, Serge. "Les castrats chanteurs : histoire, aspects médicaux." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR1M153.
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Martins, Vítor Manuel dos Santos. "Um outro Ferreira de Castro." Master's thesis, Universidade de Aveiro, 1999. http://hdl.handle.net/10773/18518.
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Viceiro-Filgueira, Javier. "Enrique Saavedra Castro: obra compositiva." Doctoral thesis, Universidade de Aveiro, 2018. http://hdl.handle.net/10773/23754.
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Doutoramento em Música<br>Este trabalho tem por objectivo servir de veículo para divulgar a obra
do maestro Enrique Saavedra Castro. Para além do estudo da sua
criação composicional, chegada aos nossos dias, procede-se à
realização da edição crítica e gravação das obras do seu catálogo
que o autor deste trabalho considera mais representativas.
O documento está dividido em quatro partes claramente
diferenciadas: A primeira delas consiste numa contextualização que
pretende ilustrar o entorno musical espanhol que rodeava Enrique
Saavedra Castro. Na segunda parte realiza-se uma revisão biográfica
e a observação da sua criação composicional, com vista a proceder à
elaboração do catálogo da sua obra. Uma terceira parte encarrega-se
de tratar diversos aspectos relacionados com a interpretação da obra
de Saavedra, através da descrição e documentação dos processos
que conduziram à gravação e aos concertos públicos levados a cabo
no âmbito deste Doutorado. Por último, a quarta parte acolhe a
edição crítica de vinte e duas obras deste compositor.<br>This work aims to serve as a vehicle to disseminate the work of the
maestro Enrique Saavedra Castro. In addition to the study of its
compositional creation, which is nowadays, we proceed to the critical
edition and recording of the works of his catalog that the author of this
work considers most representative.
The document is divided into four clearly differentiated parts: The first
one consists of a contextualization that intends to illustrate the
Spanish musical environment that surrounded Enrique Saavedra
Castro. In the second part, a biographical review and the observation
of its compositional creation are carried out, in order to proceed with
the preparation of the catalog of his work. A third part is responsible
for dealing with various aspects related to the interpretation of
Saavedra's work, through the description and documentation of the
processes leading to the recording and the public concerts carried out
within this Doctoral program. Finally, the fourth part hosts the critical
edition of twenty-two works by this composer.
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Beirante, Cândido. "Castro Soromenho : um escritor intervalar /." Lisboa : Instituto nacional de investigação científica, 1989. http://catalogue.bnf.fr/ark:/12148/cb35447500n.
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Passos, Edvard. "Castro Alves, Teatro e Teatralidade." Escola de Teatro, 2016. http://repositorio.ufba.br/ri/handle/ri/19704.
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PASSOS Edvard. Castro Alves Teatro e Teatralidade.pdf: 10884862 bytes, checksum: 22376179aba7b76af4b002e625fefb99 (MD5)<br>CAPES<br>O objeto dessa pesquisa é o conjunto de relações que o poeta Castro Alves desenvolveu com as artes cênicas: como dramaturgo, como crítico de peças de teatro, como empreendedor de sua própria obra dramática e como performer de aparições públicas espetaculares.
Procura-se apresentar Castro Alves como um artista cênico e investigar a importância das múltiplas relações desenvolvidas com as artes cênicas para edificação de seu mito.
O primeiro capítulo trata da teatralidade e da espetacularidade (segundo as definições do professor Armindo Bião) que estão presentes desde a infância e adolescência do poeta. Dezessete aparições públicas espetaculares são identificadas e apresentadas enquanto performances, tomando como suporte teórico Paul Zumthor. Busca-se com isso reposicionar o poeta na contemporaneidade, através da análise de sua atuação a partir de ferramentas teóricas de hoje.
O segundo capítulo trata do contexto do teatro no século 19, valendo-se do conceito de cronótopo de Mikhail Bahktin. Discute-se a importância do teatro e da atriz portuguesa Eugênia Câmara nos rumos da vida de Castro Alves, de sua campanha abolicionista e republicana e apresentam-se as obras dramáticas escritas por ele.
O terceiro e último capítulo trata da experiência prática de montagem da peça inédita e inconclusa de Castro Alves, A Prole dos Saturnos, ocorrida em residência artística no projeto Fafe Cidade das Artes, em Portugal.
Palavras Chave: Castro Alves, Teatro, Teatralidade, Performance, Artes Cênicas.<br>ABSTRACT - The object of this research is the set of relations that the poet Castro Alves developed with the performing arts: as a playwright, as a critic of plays, as an entrepreneur of his own dramatic work and as a performer of spectacular public appearances.
This work seeks to present Castro Alves as a scenic artist and investigate the importance of multiple relationships developed with the performing arts for building his myth.
The first chapter discusses the theatricality (according to the teacher's settings Armindo Bião) present since childhood and adolescence of the poet. Seventeen spectacular public appearances are identified as performances, taking as theoretical support Paul Zumthor. The intention is repositioning the poet in the contemporary world, through the analysis of its performance from today’s theoretical tools.
The second chapter is focused on theatre context in the 19th century, based on the concept of chronotope from Mikhail Bahktin. It discusses the influence of the theatre and the Portuguese actress Eugênia Câmara in Castro Alves's life, in his abolitionist and Republican campaign and presents the dramatic works written by him.
The third and final chapter reveals the practical experience of staging the unfinished and never seen dramatic work of Castro Alves, The Offspring of Saturns, held during the artist residency on Fafe City of Arts Project, in Portugal.
Keywords: Castro Alves, Theatre, Theatricality, Performance, Performing Arts.
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Arias, Núñez Cristián. "Centro cultural municipal de Castro." Tesis, Universidad de Chile, 2014. http://repositorio.uchile.cl/handle/2250/142786.
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Costes, Pierre. "Naissance et développement d'une ville polycentrique en milieu lagunaire: Martigues." Phd thesis, Université de Provence - Aix-Marseille I, 2010. http://tel.archives-ouvertes.fr/tel-00960168.
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Le milieu lagunaire formé par les étangs de Berre et de Caronte est né d'une ingression marine, vers 6000 av. J.-C. Si d'importants vestiges de l'Age de Fer et de l'Antiquité ont été mis à jour sur les rives de Caronte, aucun habitat n'a pu être identifié après l'époque romaine: Caronte n'est semble-t-il, au haut Moyen-Âge, qu'un lieu de passage et de pêche (présence de bourdigues, grandes nasses à poisson). Cet espace est néanmoins convoité par les divers pouvoirs locaux nés de l'effondrement de l'autorité publique, pour des motifs économiques (bourdigues), mais aussi militaires, Caronte et l'Ile formant la porte d'entrée de l'étang de Berre, et donc de la Basse Provence occidentale. La fondation de St-Geniès et du port de Bouc au XIIe s., de l'Ile-St-Geniès au XIIIe s., ainsi que de Ferrières et de Jonquières façonnent cette zone palustre : le centre-ville de la future ville de Martigues se dessine vers 1400. En 1581, la création de Martigues par l'union de l'Ile, Ferrières et Jonquières procure les bases d'un fort développement économique et démographique. La croissance de la cité s'effectue selon un modèle atypique, les phases de pression démographique induisant la création, par remblayage, de secteurs constructibles sur la lagune. Mais du fait de la faible profondeur de Caronte et de la concurrence du port de Marseille, Martigues ne peut suivre l'augmentation du tonnage des navires au XVIIIe s., et son économie connaît jusqu'à l'ère pétrochimique une longue atonie.
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VIEIRA, MARCIO DA SILVA. "INFORMATION SYSTEMS AND SUPPLY CHAIN MANAGEMENT: THE CASTROL DO BRASIL LTDA`S CASE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2005. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=7343@1.
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A gestão da cadeia de suprimentos (Supply Chain
Management - SCM) é um
novo conceito de gerenciamento dos processos de negócios
empresariais que
extrapola os limites das companhias para incluir também
seus principais clientes e
fornecedores. Com esse conceito a integração e a troca da
informação entre as
empresas tornam-se cada vez mais importante para
performace destas empresas e
de suas cadeias de suprimentos. A consolidação da SCM em
diferentes industrias
tem-se desenvolvido com o auxílio de Sistemas de
Informação (SI). Nesse
contexto, a presente dissertação tem como objetivo mapear
e analisar os principais
processos de negócio da Castrol do Brasil (subsidiária de
uma multinacional
inglesa do segmento de petróleo, a British Petrolium) sob
a perspectiva de seus
Sistemas de Informação (SI) - tanto os sistemas limitados
às fronteiras desta
empresa, como também os sistemas responsáveis pela
interface desta empresa com
alguns dos membros mais importantes de sua cadeia de
suprimento, focando,
porém, na parte produtiva e nas operações logísticas
(outbound). A partir deste
estudo elabora-se uma crítica à SCM da Castrol do Brasil
sob a perspectiva dos SI.<br>The Supply Chain Management (SCM) is a new concept of
enterprise
business processes management that surpasses the limits of
the companies to also
include its main clients and suppliers. With this concept
the integration and
information exchange among companies has become more and
more important for
these companies performance and their supply chains
systems. The SCM
consolidation in different industries has been developed
with the Information
Systems (IS) assistance. In this context, the current
dissertation aims to map and
analyse the main businesses processes of Castrol do Brasil
Ltda (which is a British
multinational subsidiary of Petroleum segment - BP) under
the perspective of its
Information Systems (IS). The dissertation will consider
either those systems
limited to this company boundaries, as well as the systems
responsible for this
company`s interface with some of its most important supply
chain members,
focusing, however, on productive part and logistic
operations (outbound). From
this study, a critic can be elaborated to Castrol do
Brasil Ltda SCM, under IS
perspective.
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BITTENCOURT, ROBERTO NUNES. "INES DE CASTRO: MYTH AND MEMORY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2007. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9988@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO<br>Inês de Castro: relicário da Saudade é uma dissertação que
discute aspectos
histórico-culturais da simbologia da saudade advinda do
episódio dos amores de
Pedro e Inês de Castro. Pela força da criação literária -
capaz de transformar a
História - fatos e ficções envolveram-se em brumas.
Passados 650 anos da morte da
mísera e mesquinha, o Ano Inesiano da Cultura reavivou
reflexões em torno de
questões como Alma Nacional, Identidade Cultural e
Sentimento Português.
No presente estudo, privilegiar-se-ão alguns textos
históricos, filosóficos e líricos
portugueses, que abordam aspectos de uma cultura que faz
da Saudade a sua força vital.<br>Ines de Castro: Myth and Memory (original title Ines de
Castro: relicário da
Saudade) is an essay that intends to discuss description-
cultural aspects of saudade
symbology from the love affair between Pedro and Ines de
Castro. By the force of the
literary creation - capable to transform History - facts
and fictions had been involved
in mists. Passed 650 years of the death of poor and
stingy, the Inesiano Year of
Culture revived reflections around the National Soul,
Cultural Identity and
Portuguese Feeling, contents of a culture that makes
saudade its reward.
36
Rey, de Castro Alarco Álvaro Santiago. "Respuesta de Alvaro Rey de Castro." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/114926.
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Botta, Patrizia. "Inés de Castro y el romancero." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/103116.
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Henry, Drew A. "Democracy in a Post-Castro Cuba /." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Dec%5FHenry.pdf.
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Gislason, Donald Garth. "Castil-Blaze, De l'opéra en France and the feuilletons of the Journal des débats (1820-1832) /." Ann Arbor : UMI, 2000. http://catalogue.bnf.fr/ark:/12148/cb370597819.
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Leandro, Jose Augusto. "Palco e tela na modernização de Castro." reponame:Repositório Institucional da UFPR, 2010. http://hdl.handle.net/1884/24678.
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Lee, Guat Ling. "Targeting AMACR to treat castrate-resistant prostate cancer." Thesis, University of Bath, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687367.
Full textAbstract:
Levels of the enzyme α-methylacyl-CoA racemase (AMACR) are increased ca. 9-fold in prostate cancer cells. AMACR is a very promising novel drug target as reducing AMACR levels converts castrate-resistant prostate cancer cells to androgen-dependent cells which will respond to androgen-deprivation. Despite the importance of AMACR in prostate and other cancers, there are very limited numbers of AMACR inhibitors described to-date. This is mainly due to the absence of a high-throughput assay for the screening of inhibitors against AMACR. The active-site residues and catalytic mechanism of human AMACR are still unknown, which make the rational design of drugs targeting AMACR very difficult. A range of novel potential inhibitors were synthesised using a rational drug design approach to explore the structure-activity relationship (SAR) on the side-chains of AMACR inhibitors. Their potencies were assessed using the fluoride elimination assay based on 1H and 19F NMR. Potency, mode of binding and kinetic parameters of these inhibitors were assessed using the multi-well colorimetric assay, which is the first AMACR high-throughput continuous assay reported to-date. A site-directed mutagenesis study was carried out to identify the active-site residues and catalytic mechanism of human AMACR. His-122, Asp-152, Met-184 and Glu-237 were identified as potential active-site residues, so the cDNA was mutated and expressed. The activity of wild-type and mutant AMACR enzymes were assessed using the deuterium wash-in, fluoride elimination and multi-well colorimetric assays. Results from these assays showed that human AMACR does not operate using a ‘two-base’ mechanism. Instead, it operates using a ‘one-base’ mechanism, most likely via water molecules acting as intermediaries within the hydrogen-bondings network in the active site. The knowledge obtained from this research informs rational drug design for this castrate-resistant prostate cancer target.
42
Jevglevskis, Maksims. "Targeting AMACR to treat castrate-resistant prostate cancer." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.681034.
Full textAbstract:
Prostate cancer is the most common male-specific form of cancer in the U.K. Current treatments for the aggressive disease by androgen-deprivation therapy gives a rapid initial response, but the disease ultimately progresses into an androgen-independent state for which there are no effective treatments. α-Methylacyl-CoA racemase (AMACR, P504S) is an enzyme which is involved in metabolism of branched-chain fatty acids and the pharmacological activation of some NSAID drugs, such as Ibuprofen and most other ‘profens’. AMACR is over-expressed in prostate cancer and some other cancers, including colon and breast cancers. Reduction of AMACR protein levels inhibits proliferation of prostate cancer cells and restores the requirement for androgens for growth. Although the exact role of AMACR in prostate cancer progression is currently unknown, several other experiments show that AMACR is functionally important for prostate cancer proliferation, validating it as a drug target. There is no convenient high-throughput assay for AMACR and as a result only a few inhibitors have been reported to date. This thesis reports a study on whether other reactions can be catalysed by AMACR. 2-Methyl-3-enoyl-CoA esters are good substrates of AMACR but do not undergo double bond migration, while 2-methyl-2-enoyl-CoA esters are not converted to products. Acyl-CoA esters that contain a fluorine atom at carbon-3 undergo a fluoride elimination reaction to give 2-methyl-2-enoyl-CoA esters. This elimination reaction was investigated for use in the development of a high-throughput assay. A fluorescent binding assay, which can be adapted for the screening of large libraries of compounds, was developed and several known and novel inhibitors were tested. Finally, metabolism of mandelic acid was investigated. It was shown that chiral inversion of mandelic acid in humans proceeds via a different pathway to Ibuprofen and related drugs, in contrast with previous reports.
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Bouvard, André. "Les peuplements castraux de la montagne du Doubs." Nancy 2, 1997. http://www.theses.fr/1997NAN21027.
Full textAbstract:
Cette thèse s'inscrit dans un programme de recherche de l'université de Nancy II, dirigé par M. Bur. Elle vise à inventorier d'une manière exhaustive, en associant l'étude du texte et celle du terrain, les peuplements castraux du Doubs, un département aux trois quarts montagnard, limitrophe de la Suisse. Dans le premier volume, l'auteur s'efforce de dégager les principaux traits du phénomène de regroupement des hommes autour du château après l'an mil. À l'exception de Montbéliard qui apparait au dixième siècle, et de quelques autres sites (Rougemont, Vercel. . . ), les dates sont généralement le treizième et le début du quatorzième siècle. Elles s'expliquent par une mise en valeur tardive des plateaux et de la montagne et par les initiatives de quelques hauts lignages, Chalon, Montfaucon, plus tard Neuchâtel, qui profitent de la carence du pouvoir comtal et épiscopal à partir de la fin du douzième siècle. En conséquence, ces bourgs connaissent pour la plupart une croissance difficile, encore accrue par le choix du site, un relief dominant dans quatre-vingt-dix pour cent des cas. Sous équipés sur le plan religieux, un peu mieux dotés sur le plan commercial, ils se caractérisent par leur extrême modestie. Cinquante-sept pour cent d'entre eux n'atteignent pas deux hectares. On ne connait qu'une ville, Montbéliard. Les autres localités sont de gros villages, qui deviendront des chefs-lieux de canton. Dans ces conditions, il est difficile de parler de mise en place d'un second réseau urbain. Ces bourgs sont enfin des organismes fragiles : presque un sur deux (45 %) est abandonné entre la fin du XVe siècle et le début du XIXe siècle. Les trois autres volumes présentent les soixante et onze sites retenus selon un canevas toujours identique : d'abord un relevé topographique ou un plan au 1/2500e basé sur le cadastre actuel, ensuite une notice qui comprend une description du site, un corpus de textes et d'images suivi d'un historique, enfin une bibliographie<br>This thesis is part of a research programme at the University of Nancy under the supervision of M. Bur. By associating both ground and textual study, it aims to make a thorough list of the castle settlements in the Doubs, a district bordering Switzerland and whose make-up is 75% mountains. In the first volume, the author strives to bring underline the main features of the grouping together around a castle phenomenon which took place after the year thousand. Except for Montbeliard which appears in the 10th century, and, a few other sites (Rougemont, Vercel. . . ), the dates are generally the thirteenth and beginning of the fourteenth century. These can be explained by the late development of the mountains and the plateau, and, by the initiatives of some noble lineages Chalon, Montfaucon and later Neufchatel exploit the lack of county and episcopal power from the end of the 12th century onwards. Consequently most of these burghs undergo a difficult development exacerbated by the choice of site, characterized in 90% of cases by dominant relief. Sub-equipped religiously speaking, a little better off commercially speaking, they are characterized by extreme modesty, 57% of them are smaller than two hectares. There is only one town, Montbeliard. The other places are just big villages which will become district country towns. Such conditions make it difficult to talk about the set-up of a second urban network. These burghs are very fragile: almost one out of two (45%) are abandoned between the end of the 15th. And the beginning of the 19th century. The three other volumes present the 71 sites selected according to a structure which is always identical: firstly a topographical summary or a map to a scale of 1/2500e, based on the present cadaster, then a note including a description of the site, a body of texts and pictures followed by historical background and finally a bibliography
44
CIPRIANI, GIULIA. "Ardea: le fortificazioni urbane e del Castrum Inui." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1216.
Full textAbstract:
La tesi ha per oggetto lo studio delle fortificazioni di Ardea e del Castrum Inui - lo scalo portuale della città – che, in quanto elementi caratterizzanti dell’urbanistica antica, hanno consentito una rilettura delle trasformazioni della città e del suo territorio. Il lavoro si compone essenzialmente di tre sezioni; in una prima parte introduttiva sono state descritte le caratteristiche geomorfologiche dei siti oggetto della ricerca ed è stata ripercorsa la storia degli studi e delle ricerche. Nella seconda parte sono state analizzate le trasformazioni dei due siti a partire dalle più antiche attestazioni - risalenti all’età del Bronzo in area urbana ed all’età arcaica nel Castrum - sino all’età imperiale; l’analisi di ogni fase è stata introdotta da uno studio relativo al contesto storico con lo scopo di determinare quali fossero gli eventi, non solo relativi ad Ardea, ma più in generale alle città del Latium Vetus, che potessero aver determinato le trasformazioni urbanistiche; sono state di volta in volta particolarmente approfondite le questioni relative alle opere di difesa e le relazioni di queste ultime con l’organizzazione dell’abitato e del porto. La possibilità di studiare un monumento inedito quale la fortificazione in opera quadrata del Castrum Inui ha fornito importanti elementi di confronto che hanno permesso di riconoscere l’esistenza di differenti fasi costruttive anche nelle mura urbane, sinora mai individuate. Infine la terza sezione è costituita dalla schedatura delle fortificazioni e comprende l’analisi dei singoli tratti attualmente visibili, realizzata descrivendone le caratteristiche costruttive e dando particolare risalto al dato metrologico, che si è rivelato particolarmente utile al fine della definizione cronologica delle diverse fasi costruttive; lo studio è pertanto completato dalle tabelle contenenti i dati relativi alla misurazioni dei blocchi ed alla posa in opera degli stessi. La tesi è infine corredata da due appendici: la prima raccoglie i testi delle citazioni tratte dalle fonti letterarie relative ad Ardea, la seconda un ampio apparato fotografico che comprende sia la documentazione relativa ai resti nello stato attuale di conservazione, sia la documentazione d’archivio che ha permesso di analizzare anche le caratteristiche dei tratti distrutti.<br>The thesis concerns the study of the fortifications of Ardea and Castrum Inui - the city harbour - which, being characteristic elements of the ancient town-planning, allowed a reinterpretation of the city and region transformations. The job consists of three sections. The first introductory section is focused on the geomorphology of the sites and on the retrace of the history of former studies and researches. In the second part were analyzed the transformation of the two sites from the earliest archaeological statements – dating back to Bronze Age in the urban area and to archaic age in the Castrum – to the imperial age. The analysis of each phase is introduced by a study on the historical context in order to determine what were the events, not only related to Ardea but more generally to the cities of Latium Vetus, which might have generated the urban transformation. From time to time were examined the issues relating to defence works and their relations with the organization of the city and its port. The opportunity to explore a formerly unpublished monument like the opus quadratum fortification of Castrum Inui has provided important elements of confrontation that led to recognize the existence of different construction phases even in the city walls, never identified up to now. Finally, the third section is the filing of the fortifications and includes the analysis of currently visible rests, made by describing the construction characteristics with particular emphasis on metrology data, which has been used for the chronological definition of the various construction phases. The study is therefore supplemented by tables containing measurements and information regarding the blocks and their installation. The thesis is finally accompanied by two appendices: the first one collects quotations pertaining Ardea coming from literary sources, the second one is a large photographic collection including both the documentation of the remains in its present state of preservation, and the archival records which helped to analyze the characteristics of destroyed traits.
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Sustiel, Tal. "Estudio de las complejidades de la gestión urbana en un encuadre neoliberal : el caso de la ciudad de Castro." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/153030.
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Dahlkvist, Viveka. "En narratologisk studie av Stefan Castas ungdomsromaner." Thesis, Högskolan Kristianstad, Sektionen för Lärarutbildning, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-8152.
Full textAbstract:
Syftet med att analysera fyra ungdomsböcker av Stefan Casta är att undersöka varje bok för sig, ur ett narratologiskt perspektiv, samtidigt som en jämförelse görs. Syftet är även att uppsatsen ska vara användbar för både lärare och elever i undervisningen och romanernas innehåll och form står i fokus. Jag avslöjar emellertid ledtrådar i romanerna och föreslår därför att romanerna läses innan uppsatsen, för att inte läsupplevelsen ska utebli. I den narratologiska analysen är det aspekter som romanernas handling, karaktärer, miljö, intertextualitet, berättare och berättelsenivåer, fokalisering samt romanens tid som fokuseras. Ett för romanerna gemensamt tema är ”kamp” och det visar sig att Stefan Castas karaktärer ofta är utanför, fundersamma och söker efter mening. Naturen i böckerna skildras både som en idyll och som ett hot och samtliga romaner berättas ur ett jagperspektiv med retrospektiva berättare där olika narrativa nivåer möts.
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MANNARINO, ANA DE GUSMAO. "AMILCAR DE CASTRO AND THE NEOCONCRETE PAGE." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2006. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9864@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO<br>Amilcar de Castro e a página neoconcreta trata do projeto
gráfico
realizado pelo escultor para o Jornal do Brasil, em
especial para o Suplemento
Dominical do Jornal do Brasil, nos últimos anos da década
de 1950. A
diagramação do suplemento é voltada, sobretudo, para
experimentação plástica,
acima de aspectos funcionais ou do ideal de transformação
do cotidiano pela arte.
Aproxima-se do pensamento neoconcreto e da fenomenologia
de Merleau-Ponty,
no que diz respeito à indissociação entre inteligível e
sensível. O projeto gráfico
para o suplemento esteve sempre em transformação, unindo
concepção e
realização no processo contínuo do fazer. Em suas páginas,
a visualidade do signo
gráfico foi intensamente explorada, estreitando a relação
entre o jornal e as
poesias concreta e neoconcreta, freqüentemente publicadas
no suplemento. Muitas
das questões trabalhadas por Amilcar de Castro em suas
esculturas e desenhos
são, de modo semelhante, exploradas pelo artista na
diagramação do jornal, um
dos meios no qual exercitou a sua poética. Nesse sentido,
destacam-se a
conjugação entre pensamento e fazer na sensibilidade do
olhar; a utilização
sempre do mínimo de elementos, priorizando as relações
entre eles; a
experimentação do espaço e do tempo como dimensões
indissociáveis,
vivenciadas a partir da motricidade e da operacionalidade.<br>Amilcar de Castro and the Neoconcrete Page deals with the
sculptor's
graphic design project for the news daily Jornal do
Brasil, and especially for the
Suplemento Dominical do Jornal do Brasil (the paper's
Sunday supplement)
during the late 1950s. Above all else, the supplement's
layout reflected visual
experimentation beyond any mere concern with functionality
or the idealized
tranformtion of everyday life by art. Insofar as it
touches upon the indissociation
between intelligibility and sensibility, it contains a
number of commonalities with
neoconcretist thought and the phenomenology of Merleau-
Ponty. During the
period in question, the supplement's graphic design
project changed continuously,
blending concepts and execution within its ongoing
creative process. The visuality
of the graphic sign was intensely explored in its pages,
strengthening the
newsaper's relationship with the concretist and
neconcretist poetry published by
the supplement. Similarly, many of the problems explored
by Amilcar de Castro
in his sculptures and drawings were also dealt with by the
artist in the newspaper's
layout as one of the mediums according to which he forged
his poetics. To this
end, we shall highlight associations between thought and
production as results of
the sensitivity of the gaze; the artist's minimalist use
of elements that focus on
inter-relationship; and the experimental use of space and
time as indissociable
dimensions experienced and based on motion and
operationality.
48
Cardoso, Patricia da Silva. "Ines de Castro ou a morta luminosa." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/270260.
Full textAbstract:
Orientador : Haquira Osakabe<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem<br>Made available in DSpace on 2018-08-01T10:46:04Z (GMT). No. of bitstreams: 1
Cardoso_PatriciadaSilva_D.pdf: 12132460 bytes, checksum: a7dd771ef15939639b2fb171fa6ded9a (MD5)
Previous issue date: 2002<br>Resumo: Este trabalho faz uma leitura do episódio histórico protagonizado por Inês de Castro, D. Monso IV, rei de Portugal, e seu filho, D. Pedro. A partir de oito versões literárias sobre esse episódio, é analisada e discutida a permanência do tema inesiano no imaginário português, sendo o problema da irreversibilidade das a ções humanas o fio condutor da leitura. A escolha desse fio condutor deve-se ao cruzamento do interesse individual com o interesse coletivo, a força que está por trás da more de Inês de Castro. Quando morre a amante do então infante D. Pedro, ele se vê obrigado a reagir. Mais do que
vingança, sua reação revela-se uma tentativa de reverter o assassinato de Inês. Dessa reação, focalizada das mais diferentes maneiras pelas versões literárias, resultará uma imagem de soberano diferente. As diferenças na compreensão do sentido da reação de Pedro apresentadas pelas versões literárias são importantes para que se pensem algumas questões relativas à
identidade cultural portuguesa, em cuja constituição a figura do bom govemante tem papel de destaque, uma vez que ela se estrutura em tomo da disposição daquele que ocupar o cargo para a defesa da autonomia nacional. Para tanto, um peso considerável é dado à necessidade de ação. Adotando a perspectiva da irreversibilidade, é possível perceber o amplo alcance do tema, que extrapola o âmbito do amor infeliz, em que costuma ser enquadrado quando se procura o motivo para seu sucesso entre o público<br>Abstract: This work offers a reading of the historical episode involving Inês de Castro, D. Afonso IV, Portugal's king, and his son, D. Pedro. Taking into account eight literary versions for this episode, I analyse and discuss the permanence of Inês de Castro as a ticcional theme in portuguese literature. The problem of the irreversibility of human actions links all eight versions. The reason why such link was chosen is related to the crossing of individual and collective interests, the force that determined Inês de Castro' s death. When she dies, Pedra, her lover, is forced to react. This reaction must be understood as an attempt
to revert Inês's murder, more than a revenge. Each literary version focuses on a different aspect of Pedro's reaction; the result is a multiplicity ofimages ofPedro as a king. AlI these different appraaches reveal a new interest in an episode which popularity
is always associated with the unhappy ending of this love history. In fact, there is an identity interest promoting the success. Since portuguese people are very concerned about their self-governrnent it is of great importance to them that their leaders know how to act to assure the independency. In such a context Pedra is taken as a kind of a parameter<br>Doutorado<br>Literatura Portuguesa<br>Doutor em Teoria e História Literária
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Mol, Elias Perigolo 1980. "Amilcar de Castro : confronto com a matéria." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/279114.
Full textAbstract:
Orientador: Nelson Alfredo Aguilar<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciências Humanas<br>Made available in DSpace on 2018-08-20T11:12:27Z (GMT). No. of bitstreams: 1
Mol_EliasPerigolo_M.pdf: 45699349 bytes, checksum: 0aa0676c63c1f2a73f7b7c3e9192234d (MD5)
Previous issue date: 2012<br>Resumo: Este estudo analisa a obra do artista mineiro Amilcar de Castro (1920-2002) e busca as relações existentes entre as suas diferentes produções: o desenho, a pintura, a gravura, sua atuação à frente da reforma gráfica no Jornal do Brasil e o restante de sua produção escultórica<br>Abstract: This study examines the work of artist Amilcar de Castro (1920-2002). It investigates the relationships between his various activities: drawing, painting, printmaking, his role leading the redesign of Jornal do Brasil as well as his sculpture production<br>Mestrado<br>Historia da Arte<br>Mestre em História
50
Centeno, R. I. "Cuban communism under Raúl Castro (2006-2014)." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12244/.
Full textAbstract:
Drawing on a theory of non-transition from communist rule, in this thesis I argue that in the period 2006-2014 Cuba experienced a change from a charismatic post-totalitarian regime to a maturing post-totalitarian one. The basic argument behind these concepts is that the loss of the charisma of Fidel Castro as a source of legitimacy – he stepped down in 2006 – has pushed forward economic performance as a compensatory source, which explains the market reforms of Raúl Castro.