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1

FRANZIN, MARTINA. "Ruolo del microbiota intestinale nel mediare gli effetti delle tiopurine in pazienti pediatrici affetti da malattie infiammatorie croniche intestinali." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3031000.

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Le malattie infiammatorie croniche intestinali (MICI) sono caratterizzate da alterazioni della composizione del microbiota intestinale, o più precisamente, da una riduzione della diversità delle specie batteriche, definita come disbiosi. In dettaglio, la famiglia delle Enterobacteriaceae ed il genere Pseudomonas proliferano maggiormente nella flora intestinale di pazienti affetti da MICI a discapito di altre specie. Le tiopurine, azatioprina (AZA), mercaptopurina (MP) e tioguanina (TG), sono farmaci comunemente usati nel mantenimento della remissione nelle MICI. Nonostante la loro comprovata
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2

Tongyoo, Narongchai. "Physical and functional analysis of genes from the cam catabolic plasmid encoding probable steps in the catabolism of camphor." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397983.

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3

Chou, Han Ting. "L-Lysine Decarboxylase and Cadaverine Gamma-Glutamylation Pathways in Pseudomonas Aeruginosa PAO1." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/103.

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In comparison to other Pseudomonas, P. aeruginosa grows poorly in L-lysine as a sole source of nutrient while fast growth mutants can be obtained. The proposed catabolic pathway involves lysine decarboxylation to cadaverine and its subsequent degradation through g-glutamylation pathway to d-aminovalerate and glutarate. The lysine decarboxylase A (ldcA) gene, previously identified as a member of the ArgR regulon of L-arginine metabolism, was found essential for L-lysine catabolism. The ldcA gene encodes a decarboxylase which takes L-lysine but not L-arginine as substrate. Contrarily, the ldcA e
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4

Madhushani, W. K. Anjana. "Multiple regulatory inputs for hierarchical control of phenol catabolism by Pseudomonas putida." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106878.

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Metabolically versatile bacteria have evolved diverse strategies to adapt to different environmental niches and respond to fluctuating physico-chemical parameters. In order to survive in soil and water habitats, they employ specific and global regulatory circuits to integrate external and internal signals to counteract stress and optimise their energy status. One strategic endurance mechanism is the ability to choose the most energetically favourable carbon source amongst a number on offer. Pseudomonas putida strains possess large genomes that underlie much of their ability to use diverse carb
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5

Dantas, Hugo Miguel Campelo. "Engineering hexuronic acid catabolism." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11776.

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Metabolic engineering is an emerging field targeted to the improvement of pathways for the production of high-value compounds. Citrus peel is produced at an estimated 15,000,000 t per year worldwide and its disposal causes environmental problems. The main constituent of citrus peel is D-galacturonic acid. The aim of this project is to convert D-galacturonic acid to useful chemicals using genetically engineered moulds. Aspergillus niger was chosen since it is naturally a good consumer of D-galacturonic acid and produces the enzymes required for citrus peel hydrolysis. In the present study, en
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6

Stankiewicz, Margaret J. "Oxidative catabolism of tetrahydropterins." Thesis, Aston University, 1989. http://publications.aston.ac.uk/12531/.

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Mixed labelled folic acid was administerd to rats. Exposure to N2O was used to give an insight into the major route of scission within the monoglutamate pool, results suggest that THF formed during transport from the gut lumen to the plasma is the major route of scission within the gut. Peroxides in corn oil and arising as a result of lipid peroxidation and autoxidation increase catabolism of the monoglutamate pool and decrease incorporation of administered folates into the polyglutamate pool. It is suggested that peroxides may oxidise B12 resulting in inhibition of methionine synthetase, this
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7

Crabbe, T. B. "Studies on the adenylate cyclase and HMGCoA reductase of the yeast Saccharomyces cerevisiae." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233812.

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8

Birch, D. J. "Carbon catabolite repression in the yeast Saccharomyces cerevisiae." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372682.

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9

Jones, Melissa Kaye. "Inositol catabolism in Drosophila melanogaster." Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1527384.

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<p> <i>myo</i>-Inositoloxygenase (MIOX) catalyzes the first step in <i>myo</i>-inositol catabolism. MIOX has not been annotated in <i> Drosophila melanogaster</i>, but the protein encoded by the <i> CG6910</i> gene is similar to the mouse MIOX protein. <i>CG6910 </i> "knocked-down" expression was explored using RNAi. "Knock-down" flies did not survive on inositol defined media, indicating that <i> CG6910</i> encodes MIOX. Survival of these flies on sucrose defined media suggest that MIOX is not essential for development. Biochemical assays demonstrated that <i>D. melanogaster</i> has MIOX acti
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10

Brummett, Adam Eugene. "Enzymology of microbial dimethylsulfoniopropionate catabolism." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5430.

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The biosynthesis of DMSP by phytoplankton and algae has wide ranging impact on marine organisms. Release of DMSP and uptake by marine bacteria leads to the eventual catabolism of this osmolyte. Enzymatic breakdown of DMSP leads to acrylate and volatile DMS production, which is fluxed into the atmosphere. When DMS enters the atmosphere it undergoes oxidation, acting as nucleation sites for water. The nucleation of water, and the subsequent cloud formation increases the albedo and reflects solar radiation. Global climate has therefore been hypothesized to be dependent upon DMSP breakdown to DMS.
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11

Kandasamy, Dineshkumar. "Study on yeast enzymes Urc1p and Urc4p in a novel uracil catabolism pathway (URC)." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185013.

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Purine and pyrimidine bases are the central precursors of DNA and RNA and theirintracellular concentration is balanced by three pathways- de novo, salvage and catabolicpathways. Uracil catabolism pathway has been found in several bacteria and in some fungi(including yeast). Seven genes, URC1-7 have been found to be involved in this novelpathway. There are two “unknown genes” in the yeast Lachancea (Saccharomyces) kluyveri,namelyURC1 and URC4, which play a central role in this pathway and their exact functionremains a mystery.In this project, two S. kluyveri genes, URC1&amp;URC4, were over-expr
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12

Grimsley, Philip George Medical Sciences Faculty of Medicine UNSW. "Receptor mediated catabolism of plasminogen activators." Awarded By:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/44489.

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Humans have two plasminogen activators (PAs), tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), which generate plasmin to breakdown fibrin and other barriers to cell migration. Both PAs are used as pharmaceuticals but their efficacies are limited by their rapid clearance from the circulation, predominantly by parenchymal cells of the liver. At the commencement of the work presented here, the hepatic receptors responsible for mediating the catabolism of the PAs were little understood. tPA degradation by hepatic cell lines was known to depend on the forma
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13

Rhys-Williams, William. "The microbial catabolism of 4-nitrotoluene." Thesis, Bangor University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359756.

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14

Robertson, Colin Daniel. "Anerobic catabolism of glycerol by Klebsiellae." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330032.

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15

Winson, Michael Kenneth. "Molecular biological studies on catabolic plasmids." Thesis, Bangor University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305927.

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16

Beck, Susan A. "Catabolic factors in tumour-induced cachexia." Thesis, Aston University, 1989. http://publications.aston.ac.uk/12508/.

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A transplantable colon adenocarcinoma of the mouse (MAC16) was utilized as a model of human cancer cachexia. The MAC16 tumour produced extensive weight loss in the host at small tumour burdens and without a reduction in either food or fluid intake. The weight loss was characterised by a decrease in both carcass fat and muscle mass which were directly proportional to the weight of the tumour. The weight loss has been correlated with the production of circulatory catabolic factors by the tumour, which degrade host muscle and adipose tissue in vitro. These factors were further characterised and h
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17

Platt, Alison. "A study of 4-hydroxy-2-oxovalerate aldolase from the meta pathway operon of the nah plasmid pWW60-22." Thesis, Bangor University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239887.

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18

Rafudeen, M. S. "Investigation of carbon catabolite repression in Clostridium beijerinckii NCIMB 8052." Doctoral thesis, University of Cape Town, 2001. http://hdl.handle.net/11427/4326.

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Summary in English.<br>Includes bibliographical references.<br>The substrate basis for the industrial acetone-butanol-ethanol (ABE) fermentations, has been agricultural products rich in starch or sucrose, and employed taxonomically distinct amylolytic and saccharolytic solventogenic clostridial strains respectively. There is evidence to suggest that the utilization of these substrates is subject to carbon catabolite repression. In Gram-positive bacteria, carbon catabolite repression is controlled by a global regulatory mechanism, central to which is an imperfect palindromic sequence, the cre e
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19

Mayer, Stephen Armond. "Carbon catabolite repression of yeast CBP1 mRNA 3' end formation." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185336.

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CBP1 is a yeast nuclear gene encoding a mitochondrial protein that stabilizes the 5' end of cytochrome b (cob) pre-mRNA. Cytochrome b is the only mitochondrially synthesized component of the respiratory chain Complex III. Since the nuclearly-encoded subunits of this complex are regulated at the transcriptional level by catabolite repression, we hypothesized that CBP1 might be similarly regulated. To test the idea that transcriptional regulation of CBP1 could coordinate an increase in cytochrome b mRNA stability with an increase in nuclearly-encoded Complex III subunit production, we characteri
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20

Floderus, Eugenie. "Aminopeptidases and arginine catabolism in oral straptococci." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1990. http://books.google.com/books?id=bMZpAAAAMAAJ.

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21

Broome, Malcolm Charles, and mikewood@deakin edu au. "Aspects of milk protein catabolism by lactobacilli." Deakin University. School of Sciences, 1988. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050902.120502.

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Lactobacillus plantarum and subspecies of Lactobacillus casei were isolated from good quality mature Cheddar cheese and characterized with respect to metabolic functions that would allow their use in cheesemaking. In this way microbiological control of the maturation process with particular emphasis on protein catabolism was achieved. The lactobacilli isolated were selected for low growth rates (and acid production) in milk, and low proteinase activity to allow for their addition in high numbers to cheesemilk together with the normal starter flora (group N streptococci). The growth and acid p
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22

Walters, Nicola Jane. "Arginine and proline catabolism in Schizosaccharomyces pombe." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257192.

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23

Sherburn, Richard. "The microbial catabolism of metalworking fluid additives." Thesis, University of Hull, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301630.

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24

Love, Charmaine. "PrP catabolites as determinants of TSE susceptibility." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5709.

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Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases that are characterised by long incubation periods, protein aggregation and vacuolation. During TSE pathogenesis the normal, cellular prion protein, (PrPC), which is encoded by the gene PRNP, misfolds and accumulates as abnormal disease associated prion protein, (PrPSc) within the central nervous system. Variants of the Prion protein gene are associated with susceptibility to TSE disease. For example sheep scrapie disease is modulated by several PRNP alleles, with certain alleles carried by suscepti
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25

Wilkins, M. P. "The role of oxyhaems in haem catabolism." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373588.

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26

Sudjadi. "Analysis of cloned genes for GABA catabolism." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/35163.

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A putative hpa+ clone has been isolated allowing an Hpa-Hpc+ mutant CD03 to growth on 4-HPA. Detection of a 4-HPA monooxygenase from extracts was unsuccessful. When it became apparent that gab genes had been cloned the emphasis switched to detailed analysis of those genes. The gab genes were isolated using suppression of a mutant CT101 defective in the sad gene. It seems that the cloned gabDT genes encoding NADP-dependent SSA dehydrogenase and GABA transaminase are responsible for these, not the gabD gene only. Possible explanation of these phenomena are described. E.coli C and K-12 cannot uti
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27

Lawson, Kathryn René. "Catabolism as a mechanism of polyamine detoxification." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/288919.

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Maintenance of optimal polyamine pool levels is critical for cell survival. Intracellular polyamine depletion is usually cytostatic, whereas unregulated polyamine accumulation can result in cytotoxicity. The purpose of this work was to examine the importance of polyamine depletion in cell survival, either through increased polyamine catabolism or decreased polyamine synthesis. The polyamine analogue CHENSpm, which induces apoptosis in several cell lines, was used to examine the role of polyamine catabolism in cell survival. The susceptibility of Chinese hamster ovary cells and HCT 116 human co
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28

Kuhn, Hallie. "Regulation of Yolk Catabolism in Early Embryogenesis." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845424.

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Yolk provides an important source of nutrients during the early development of oviparous (non-platental) organisms. In addition to phosphate and lipids, it is com- posed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by acidification of the yolk platelet, leading to the activation of cathepsin-like proteases that degrade yolk contents, but it is unknown how this process is triggered. Using maternal shRNA technology in Drosophila melanogaster embryos we find that yolk catabolism depends on components of the Tor path
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29

Hildebrandt, Tatjana [Verfasser]. "Amino acid catabolism in plants / Tatjana Hildebrandt." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2019. http://d-nb.info/1204458634/34.

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30

Damaraju, Sridevi. "Analysis of proteins involved in chlorophyll catabolism." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16322.

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Der Abbau des Chlorophyll (Chl) ist ein Prozess, der typischerweise während der Blattseneszenz und der Reifung von Früchten und Samen stattfindet. Eine Störung dieses koordinierten Prozesses unter Frostbedingungen verzögert den Chl-Abbau und ist ein grosses Hindernis bei der Herstellung von hochwertigem Rapsöl. Der Abbau von Chl zu farblosen Kataboliten erfolgt in einer Serie von enzymatischen Schritten und wird durch die Chlorophyllase begonnen (Chlase). Es wurde vorgeschlagen, dass ein wasserlösliches Chl Protein (WSCP) den Transport des Chl von der Thylakoidmembran zum Wirkort der Chlase üb
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Durkin, Shannon M. "Complementation of the sor-4 Gene of Neurospora Crassa." Youngstown State University / OhioLINK, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1004562481.

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Sonoda, Yo. "Structural and functional analysis of a sporulation protein Spo0M from Bacillus subtilis." Kyoto University, 2016. http://hdl.handle.net/2433/215587.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19761号<br>農博第2157号<br>新制||農||1039(附属図書館)<br>学位論文||H28||N4977(農学部図書室)<br>32797<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授 三上 文三, 教授 加納 健司, 教授 喜多 恵子<br>学位規則第4条第1項該当
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La, Cecilia Daniele. "Comprehensive modeling of agrochemicals biodegradation in soil: A multidisciplinary approach to make informed choices to protect human health and the environment." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20691.

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Numerical models are used to predict the dynamics of potentially hazardous pesticides in soil. Those models may account for fundamental processes affecting pesticide dynamics, such as environmental and edaphic conditions, water flow, degradation, and sorption. However, those models lack the ability to account for complex biogeochemical and ecological feedbacks, and thus create challenges in achieving robust predictions. In particular, no attention has been paid on the coupled mechanistic description of microbial dynamics and soil organic matter cycling and the implications on agrochemicals bio
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Horton, William Henry Clay. "Characterization of the Components of Carbon Catabolite Repression in Clostridium perfringens." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/36119.

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Clostridium perfringens is a versatile pathogen capable of causing a wide array of diseases, ranging from clostridial food poisoning to tissue infections such as gas gangrene. An important factor in virulence as well as in the distribution of C. perfringens is its ability to form an endospore. The symptoms of C. perfringens food poisoning are directly correlated to the release of an enterotoxin at the end of the sporulation process. The sporulation process in C. perfringens is subject to carbon catabolite repression (CCR) by sugars, especially glucose. CCR is a regulatory pathway that alters t
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Sabiston, C. Paul. "The role of catabolin in experimental osteoarthritis." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24909.

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The pathogenesis of osteoarthritis (OA) is complex, but likely involves destruction of articular cartilage by endogenous enzymes (Dingle 1979). Factors controlling this are not well understood. Cetabolin, a 21,000 molecular weight peptide structurally end functionally related to interleukin-1, stimulates living but not killed chondrocytes in vitro to degrade their matrix (Fell and Jubb 1977, Saklatvala et al. 1983), suggesting it is not itself a degradative enzyme but functions as a control factor. The work in this thesis investigated the possible role of cetabolin in the pethogenesis of OA by
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Lemley, Caleb Owens. "Alterations in progesterone catabolic enzymes by insulin." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5286.

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Yang, Yifan. "Catabolic responses to resistance exercise in humans." Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1317922.

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Peel, Michelle C. (Michelle Carolyn) Carleton University Dissertation Biology. "Catabolic genotype distributions in the Niagara watershed." Ottawa, 1996.

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39

Steward, W. P. "The structure of proteoglycans associated with normal and malignant cells." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234215.

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Hou, Chunsheng 1968. "Sulfur amino acid catabolism in a piglet model." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78381.

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A model was developed in growing piglets to study the use of urinary total sulfur excretion as an indicator of sulfur amino acid (SAA) catabolism and the nitrogen (N)/sulfur (S) balance ratio as an indicator of non-protein SAA storage. The recovery of administrated methionine as urinary total S over 48 hours was 106% in well-nourished piglets, but only 69% in protein malnourished piglets. The N/S balance ratio of protein malnourished piglets was lower than that of well-nourished piglets, and this ratio further decreased after methionine administration. We conclude that in a protein maln
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Carvallo, Sergio Luis Fuenmayor. "Catabolism of naphthalene by Pseudomonas sp. strain U2." Thesis, Bangor University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263318.

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Yang, M. "Catabolism and bioactivity of bradykinin and related peptides." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557857.

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Bradykinin and related peptides (BRPs) are common components of amphibian defensive skin secretions, particularly in ranid and phyllomedusine frogs and in bombinid toads. BRPs are known to be highly vasoactive with some possessing potent effects on blood vessel formation (angiogenesis) - a process known to be initiated by direct effects on endothelial cells. Human microvessel endothelial (HMEC) cells are a stable laboratory cell line often used for preliminary screening in such studies of BRP function. Since these cells are the starting points for fundamental biological studies, we examined th
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James, V. J. "Regulation of xenobiotic catabolism in plant tissue culture." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380205.

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Le, Tissier Paul Roussel. "The biochemical genetics of purine catabolism in mice." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236393.

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Wade, David Patrick. "Receptor-mediated catabolism of lipoproteins by the liver." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47700.

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Raucoules, Daniel. "Catabolites plasmatiques des monoamines et depressions : etude preliminaire." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20954.

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Ummadi, Madhavi. "Tryptophan Catabolism in Brevibacterium linens BL2." DigitalCommons@USU, 2002. https://digitalcommons.usu.edu/etd/5501.

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Recent studies suggest aromatic amino acid catabolism by starter lactococci and flavor adjunct bacteria have a significant impact on off-flavor development during Cheddar cheese ripening. We hypothesized that a flavor adjunct bacterium, Brevibacterium linens BL2, produces off-flavor compounds from aromatic amino acid metabolism that will have a detrimental impact on cheese flavor. The mechanism of tryptophan (Trp) catabolism in Brevibacterium linens BL2, was investigated in a chemically defined medium during incubation in laboratory conditions (no carbohydrate, pH 6.50, 220 rpm, 25°C) and chee
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Debailleul, Fabien. "A new expression system in Saccharomyces cerevisiae based on nitrogen catabolite regulation." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209428.

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SUMMARY<p><p>Gap1, the general amino acid permease of Saccharomyces cerevisiae, is a plasma membrane protein which is synthesized and most active under conditions of poor nitrogen supply. Under these conditions, the role of Gap1 is to scavenge external amino acids to be used as nitrogen sources or directly as building blocks for protein synthesis. Gap1 is a member of the Yeast Amino Acid Transporter (YAT) family, a family of amino acid transporters highly conserved in bacteria and fungi. <p>The intracellular trafficking of Gap1 has been the subject of intense investigation as well as the role
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DeGrazia, Henry. "A biophysical investigation of the mechanisms of the catabolite gene activator protein." Diss., Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/25641.

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O'Donnell, Kevin John. "Studies on the behaviour of catabolic plasmid pWW15." Thesis, Bangor University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280644.

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