Academic literature on the topic 'Catechines'

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Journal articles on the topic "Catechines"

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He, Hua-Feng, and Yang Ye. "Discrimination Based on Volatile Compounds and Differential Analysis of Chinese Dark Tea." Journal of Agricultural Science 8, no. 9 (August 5, 2016): 115. http://dx.doi.org/10.5539/jas.v8n9p115.

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<p>Simultaneous distillion and extraction (SDE)/gas chromatographymass spectrometry (Gc-Ms) detection coupled with partial least squares-discriminate analysis (PLS-DA) were used to discriminate Chinese dark teas (CDTs). A total of 84 volatile compounds were taken to conduct the cluster analysis. 9 kinds of CDTs could be divided into 3 groups in consistent with the manufacturing processes. Besides, ingredients that were related with the quality of CDT, such as free amino acid, soluble sugar and catechines were analyzed. Differential trends were disclosed between Pu-Er raw tea and Pu-Er ripe tea as well as raw dark green tea (RDGT).</p>
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Rogovskii, Vladimir S., Sergey V. Popov, Nikolai V. Sturov, and Nikolai L. Shimanovskii. "The Possibility of Preventive and Therapeutic Use of Green Tea Catechins in Prostate Cancer." Anti-Cancer Agents in Medicinal Chemistry 19, no. 10 (October 24, 2019): 1223–31. http://dx.doi.org/10.2174/1871520619666190404153058.

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Background:Prostate cancer is one of the most frequent types of cancer. Despite the existence of various treatment strategies, treatment of prostate cancer still presents serious difficulties (especially in advanced stages). Polyphenols have been extensively assessed in terms of their potential use for prostate cancer treatment and prevention. Catechins are among the most well-known polyphenols in this respect.Objective:In this review, we summarize clinical study results concerning catechin applications with regard to prostate cancer treatment and prevention. We discuss some of the main mechanisms of the anticarcinogenic action of catechins.Conclusion:The main mechanisms of the anticarcinogenic action of catechins are subdivided into two major types: (i) direct action on cancer cells and (ii) indirect effect based on catechins’s impact on the microenvironment of cancer cells, particularly in relation to the immune system. At this level catechins might reduce tumor-associated inflammation and immune tolerance.
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Markina, O. V., E. V. Maksimenko, N. V. Markin, N. A. Selyanskaya, A. I. Shelokhovich, A. B. Mazrukho, and N. I. Borisenko. "STUDY OF COMPOSITION OF PLANT EXTRACTS, POSSESSING ANTIMICROBIAL EFFECT AGAINST VIBRIO CHOLERAE EL TOR, USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY." Journal of microbiology epidemiology immunobiology, no. 1 (February 28, 2016): 63–66. http://dx.doi.org/10.36233/0372-9311-2016-1-63-66.

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Aim. Study the composition of plant extracts using high-performance liquid chromatography (HPLC) and evaluation of their antimicrobial effect against Vibrio cholerae El Tor. Materials and methods. Qualitative and quantitative composition of plant extracts was studied using HPLC. Determination of sensitivity of microorganisms to plant extracts was carried out by diffusion into agar method and serial dilutions method. Results. Antibacterial effect of water, water-alcohol and acetone extracts of roots of Limonium gmelinii L., Berberis vulgaris L. and Glycyrrhiza glabra L. was studied. The most effective methods of extraction of biologically active substances, possessing antimicrobial effect against various strains of V.cholerae El Tor, were determined. Conclusion. The use of HPLC allowed to establish the presence of catechines, alkaloids protoberberines and glycyrrhizic acid in extracts, possessing antimicrobial effect against V.cholerae El Tor strains.
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Furushima, Daisuke, Takuma Nishimura, Norikata Takuma, Ryo Iketani, Tomohito Mizuno, Yuji Matsui, Tohru Yamaguchi, et al. "Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial." Nutrients 12, no. 1 (December 18, 2019): 4. http://dx.doi.org/10.3390/nu12010004.

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Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test, p = 0.042). The hazard ratio (95% confidence interval (CI)) with reference to the placebo group was 1.09 (0.61–1.92) in the low-catechin group and 0.46 (0.23–0.95) in the high-catechin group. These findings suggest that catechins combined with xanthan gum protect against URTIs.
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Naparlo, Katarzyna, Grzegorz Bartosz, Ireneusz Stefaniuk, Bogumil Cieniek, Miroslaw Soszynski, and Izabela Sadowska-Bartosz. "Interaction of Catechins with Human Erythrocytes." Molecules 25, no. 6 (March 24, 2020): 1456. http://dx.doi.org/10.3390/molecules25061456.

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The aim of this study was to characterize the interaction of chosen catechins ((+)-catechin, (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG)) with human erythrocytes and their protective effects against oxidative damage of erythrocytes. Uptake of the catechins by erythrocytes was studied by fluorimetry, their interaction with erythrocyte membrane was probed by changes in erythrocyte osmotic fragility and in membrane fluidity evaluated with spin labels, while protection against oxidative damage was assessed by protection against hemolysis induced by permanganate and protection of erythrocyte membranes against lipid peroxidation and protein thiol group oxidation. Catechin uptake was similar for all the compounds studied. Accumulation of catechins in the erythrocyte membrane was demonstrated by the catechin-induced increase in osmotic resistance and rigidification of the erythrocyte membrane detected by spin labels 5-doxyl stearic acid and 16-doxyl stearic acid. (−)-Epigallocatechin and EGCG inhibited erythrocyte acetylcholinesterase (mixed-type inhibition). Catechins protected erythrocytes against permanganate-induced hemolysis, oxidation of erythrocyte protein thiol groups, as well as membrane lipid peroxidation. These results contribute to the knowledge of the beneficial effects of catechins present in plant-derived food and beverages.
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Sasaki, Geoffrey, Yael Vodovotz, Zhongtang Yu, and Richard Bruno. "Catechin Bioavailability Is Reduced in Obese Persons Without Altering Gut Microbial-Derived Valerolactones Following Consumption of a Green Tea Extract Confection." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 468. http://dx.doi.org/10.1093/cdn/nzaa045_101.

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Abstract Objectives Green tea extract (GTE) protects against obesity in rodents by reducing gut permeability that otherwise provokes endotoxemia-mediated inflammation. However, whether obesity affects catechin bioavailability and microbial metabolism is unknown. We hypothesized that obesity will reduce catechin bioavailability by increasing microbial biotransformation of catechins. Methods Obese persons (n = 10 M/7F; 33.5 ± 0.7 kg/m2) and age-matched healthy persons (n = 10 M/9F; 21.7 ± 0.4 kg/m2) completed a pharmacokinetics (PK) trial in which a GTE confection [290 mg epigallocatechin gallate (EGCG), 87 mg epigallocatechin (EGC), 39 mg epicatechin (EC), 28 mg epicatechin gallate (ECG)] was ingested prior to collecting plasma at 0, 0.25, 0.5, 1, 2, 3, 5, 8, 10, and 12 h and urine from 0–4, 4–8, 8–12, and 12–24 h. Stool samples were collected and gut permeability was assessed prior to the 12-h PK trial. Plasma and urinary catechin/catechin-derived microbial metabolites were assessed following enzymatic hydrolysis by LC-MS. Results Regardless of health status, relative bioavailability, based on plasma area under the curve (AUC0–12 h), of GTE catechins were: EGCG &gt; EGC &gt; ECG &gt; EC. However, obese persons had 24–27% lower plasma AUC0–12 h for the four catechins compared to lean persons (P &lt; 0.05). They also had 18–36% lower maximum plasma concentrations (Cmax) of GTE catechins but 12 h plasma catechin concentrations were unaffected by obesity status (P &gt; 0.05). 3ʹ,4ʹ-γ-valerolactone (3,4-VL) was detected in the plasma of all participants, while 3ʹ,4ʹ,5ʹ-γ-valerolactone (3,4,5-VL) was detected in 74% and 82% of lean and obese persons, respectively. Plasma AUC0–12 h for these VL metabolites did not differ by obesity status. EGC, EC, 3,4-VL, and 3,4,5-VL, but not EGCG and ECG, were primarily present in urine and urinary total VLs were increased compared with total urinary catechins. However, 24-h urinary excretion of catechins and VLs were unaffected by obesity. Conclusions Obesity reduces GTE catechin bioavailability and Cmax independent of any change in VL metabolite appearance or urinary elimination of catechins, suggesting a gut-level mechanism that limits catechin absorption. Funding Sources Supported by USDA-NIFA and the Foods for Health Discovery Theme at The Ohio State University.
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Ai, Zeyi, Shuyuan Liu, Fengfeng Qu, Haojie Zhang, Yuqiong Chen, and Dejiang Ni. "Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers." Molecules 24, no. 6 (March 26, 2019): 1185. http://dx.doi.org/10.3390/molecules24061185.

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The transcellular transport and metabolism of eight green tea catechins (GTCs) were studied in Caco-2 monolayers, with the aim of investigating the effect of cis–trans isomerism on the membrane permeability and biotransformation of GTCs. The results showed that the catechin stereochemistry significantly affects the efflux transport rather than the absorption transport in the Caco-2 monolayers. The trans catechins showed a better transcellular permeability than their corresponding cis (epi) catechins in the efflux transport, as the efflux amount of trans catechins were all significantly higher than that of the cis (epi) catechins at each concentration and each time point tested. Moreover, the relative contents of the (+)-catechin (C)-O-sulfate, (+)-gallocatechin (GC)-O-sulfate, (−)-catechin gallate (CG)-O-sulfate, and (−)-gallocatechin gallate (GCG)-O-sulfate in the efflux transport were 2.67, 16.08, 50.48, and 31.54 times higher than that of the (−)-epicatechin (EC)-O-sulfate, (−)-epigallocatechin (EGC)-O-sulfate, (−)-epicatechin gallate (ECG)-O-sulfate, and (−)-epigallocatechin gallate (EGCG)-O-sulfate, respectively. It indicated that more metabolites were observed after the transcellular efflux of trans catechins. Furthermore, after two hours of incubation, the GTCs could significantly increase the expression of multidrug resistance-associated protein 2 (MRP2) and breast cancer-resistance protein (BCRP), and decrease the expression of P-glycoprotein in the Caco-2 cells. The regulation of GTCs on P-glycoprotein, MRP2, and BCRP could also be significantly influenced by the chemical and dimensional structure. In a conclusion, catechin stereochemistry significantly affects the transport and metabolism of GTCs when refluxed in the Caco-2 monolayers.
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Furushima, Daisuke, Yu Otake, Natsumi Koike, Shintaro Onishi, Takuya Mori, Noriyasu Ota, and Hiroshi Yamada. "Investigation of the Oral Retention of Tea Catechins in Humans: An Exploratory Interventional Study." Nutrients 13, no. 9 (August 29, 2021): 3024. http://dx.doi.org/10.3390/nu13093024.

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Green tea catechin ingestion or gargling exhibit anti-viral activity against upper respiratory infection. We hypothesized that retention in the oral cavity could improve the anti-viral effects of catechins. The present study investigated the oral retention of catechins in humans and the effect of catechin beverage viscosity on oral retention. Two intervention studies with different test beverages, beverage-C (40 mL, containing 73.4 mg of catechins) and beverage-XT (40 mL, beverage-C containing 100 mg xanthan gum) were conducted in 20 healthy volunteers (mean age 38.7 years). Catechin concentrations were measured in buccal mucosa samples collected at 10 min, 40 min, and 60 min after ingesting test beverages, and the catechin variability of the tissue after intake was compared between test beverages. As a result, the mean (SEM) concentrations of EGCG were 99.9 (27.2), 58.2 (16.6), and 22.3 (5.7) ng/mg-mucosa at 10, 40, and 60 min, respectively, after ingestion of beverage-XT. Similarly, the catechin concentrations were 86.1 (20.3), 32.2 (5.3), and 27.8 (5.9) ng/mg-mucosa after ingestion of beverage-C. The total retention volume over 60 min tended to be slightly higher after ingestion of beverage-XT, though the difference was not statistically significant. Additional studies are needed to confirm the effect of xanthan gum on improving oral retention of catechins.
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Mohd Zin, Zamzahaila, Nursyafiqah Mohamad, Chong Kah Hui, Nurul Izwanie Majid, and Mohd Khairi Zainol. "Effect of Acidified Ethanol on Antioxidant Properties of Morinda citrifolia Leaf Extract and Its Catechin Derivatives." Current Research in Nutrition and Food Science Journal 9, no. 1 (April 27, 2021): 172–83. http://dx.doi.org/10.12944/crnfsj.9.1.17.

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This study was conducted to investigate the effect of ethanol acidification on the antioxidant properties of Morinda citrifolia leaf (MCL) extract and its catechin derivatives. Four different ethanol (100%, 99.5%, 70%, 50%) with or without 0.5% acetic acid were used for extraction. The antioxidant profile was studied with DPPH radical scavenging activity, FRAP and TPC. The quantification of catechins in MCL was performed using HPLC, and the identification of catechins derivatives was performed with Ultra UPLC-TWIMS-QTOF. The results showed that an extraction solvent composed of 70% ethanol: 29.5% water: 0.5 % acetic acid exhibited the highest DPPH percentage of inhibition (86.12±2.96%) and highest TPC value with 97.80±0.25 mg GAE/g extract, while 100% ethanol acidified with 0.5% acetic acid showed highest FRAP antioxidant power with 1.31±0.05mg FSE/g extract. All eight types of catechins were identified in MCL and the most total catechins were quantified in 70% ethanol: 29.5% water: 0.5 % acetic acid at 153.57mg/g. The catechin derivatives identified included epigallocatechin-3-O-gallate (EGCG), epigallocatechin (4β, 8)-gallocatechin, gallocatechin (4α→8)-epicatechin, catechin-3-O-gallate (CG) and epigallocatechin (EGC). The results suggest that acidification improves the extraction of polyphenols as well as catechin content.
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Zheng, Kaiwen, Kai Guo, Jing Xu, Wei Liu, Junlang Chen, Can Xu, and Liang Chen. "Study on the interaction between catechin and cholesterol by the density functional theory." Open Chemistry 18, no. 1 (May 28, 2020): 357–68. http://dx.doi.org/10.1515/chem-2020-0038.

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AbstractCatechin – a natural polyphenol substance – has excellent antioxidant properties for the treatment of diseases, especially for cholesterol lowering. Catechin can reduce cholesterol content in micelles by forming insoluble precipitation with cholesterol, thereby reducing the absorption of cholesterol in the intestine. In this study, to better understand the molecular mechanism of catechin and cholesterol, we studied the interaction between typical catechins and cholesterol by the density functional theory. Results show that the adsorption energies between the four catechins and cholesterol are obviously stronger than that of cholesterol themselves, indicating that catechin has an advantage in reducing cholesterol micelle formation. Moreover, it is found that the molecular interactions of the complexes are mainly due to charge transfer of the aromatic rings of the catechins as well as the hydrogen bond interactions. Unlike the intuitive understanding of a complex formed by hydrogen bond interaction, which is positively correlated with the number of hydrogen bonds, the most stable complexes (epicatechin–cholesterol or epigallocatechin–cholesterol) have only one but stronger hydrogen bond, due to charge transfer of the aromatic rings of catechins.
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Dissertations / Theses on the topic "Catechines"

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BREZILLON, CHRISTOPHE. "Metabolismes endogene et bacterien des catechines composes polyphenoliques majeurs du vin rouge. Etude in vitro et in vivo chez le rat a flore humaine." Paris, Institut national d'agronomie de Paris Grignon, 2001. http://www.theses.fr/2001INAP0015.

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La catechine et l'epicatechine sont des microconstituants polyphenoliques accredites d'une action preventive vis-a-vis des maladies cardio-vasculaires et de certains cancers. Notre objectif etait d'identifier, en comparant le rat sans germe (rsg) et le rat heteroxenique a flore humaine (rfh), des metabolites endogenes et bacteriens susceptibles d'activites biologiques. Des methodes chromatographiques (clhp) et spectrometriques (sm et rmn) conduisent a caracteriser les metabolites. Des etudes in vitro servent a identifier des bacteries responsables. En associant des bilans digestifs et metaboliques, chez le rsg, nous montrons que la catechine ingeree est largement absorbee et metabolisee au niveau endogene, seul 2% se retrouve a l'etat natif dans l'urine et 8% dans le caecum. La presence des formes glucuronidees et/ou sulfatees dans le caecum (4 mol/g ms) revele l'importance du cycle entero-hepatique. Dans l'urine et/ou les feces nous retrouvons egalement des formes methylees et, encore jamais decrites, des formes (ent) (ent)-epicatechine, 3-o-methyl-(ent)-epicatechine. Les etudes in vitro revelent la bioconversion de la catechine par la flore fecale du rfh dont nous isolons 13 souches actives : eggerthella lenta (n= 1), escherichia coli (n= 6) et enterococcus faecalis (n= 6). In vivo, au moins 10% de la catechine est transformee en plusieurs metabolites bacteriens : trois lactones la 5--(3, 4- dihydroxyphenyl)--valerolactone la 5--(3-hydroxyphenyl)--valerolactone, la 5--(4-hydroxy, 3-methoxyphenyl)--valerolactone et l'acide 3-hydroxyphenylpropionique, tous excretes par voie urinaire, temoignant de leur absorption massive. L'absence de metabolites endogenes fecaux temoigne de leur metabolisme secondaire par la flore. L'epicatechine se differencie de la catechine par une absorption superieure, l'emergence d'un nouveau metabolite endogene, l'epiafzelechine, et la stereospecificite des metabolites bacteriens. Les effets sante pourraient donc dependre d'un triple partenariat (absorption, transformation endogene, transformation bacterienne) s'exercant de facon locale et/ou systemique. Les activites biologiques de certains metabolites tels que les acides phenoliques et l'epiafzelechine ont deja fait l'objet d'etudes recentes, celles des formes (ent) restent a decouvrir.
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Flôres, Maíra Frigo. "Efeitos do exercício físico e da suplementação com chá-verde sobre características bioquímicas e comportamentais associadas ao envelhecimento." Universidade Federal do Pampa, 2013. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/308.

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Made available in DSpace on 2016-04-08T19:23:35Z (GMT). No. of bitstreams: 1 Maíra Frigo Flores.pdf: 606784 bytes, checksum: 320f5eb7c4c92844adfadf846bcd39d7 (MD5) Previous issue date: 2013-11-08
O envelhecimento causa rejuízos cognitivos e de memória que têm sido relacionados com o estresse oxidativo (EO). Descobrir formas de atenuar o EO é importante para minimizar perdas cognitivas. O exercício físico e as catequinas constituintes do chá verde são potenciais antioxidantes que podem auxiliar na proteção das funções cognitivas e de memória. Ao passo que evidências sugerem papel neuroprotetor do exercício, efeitos do chá verde durante o envelhecimento como estratégia para combater o EO ainda são bastante incipientes. Essa pesquisa verificou os efeitos do exercício físico e da suplementação com o chá verde sobre aspectos bioquímicos e comportamentais associados ao envelhecimento. Ratos Wistar com 9 meses de idade foram divididos em grupos, sendo eles: controle, exercício, chá verde, exercício e chá verde, além de um grupo controle jovem. As intervenções foram feitas por três meses, constando de exercício aeróbico e ingestão de chá verde de maneira isolada, e realização de exercício aeróbico com concomitante ingesta de chá verde. Em conclusão, o chá verde não evitou déficits cognitivos no envelhecimento, mas diminuiu as espécies reativas aumentando as defesas antioxidantes. O exercício melhorou diversos parâmetros bioquímicos e comportamentais. A falta de efeito do chá verde na cognição pode estar relacionada com as características da intervenção, ao passo que a diminuição nas espécies reativas sugere um papel de proteção do chá verde mesmo em um período curto de suplementação.
Aging is associated with cognitive and mnemonic deficits frequently reported as related to the oxidative stress (OS). There is continuous interest to minimize effects of OS in order to avoid cognitive deficits. Physical exercise and catechines from green tea are potential antioxidants helping to protect cognitive and memory functions. While there are evidences supporting the neuroprotective role of physical exercise, the effects of green tea supplementation during aging as strategy to combat OS still are quiet incipient. In this study the effects of physical exercise and green tea supplementation on biochemical and behavioral characteristics associated with aging were addressed. Wistar rats 9 months aged were organized in groups as follow: young control group; aged control group; exercise aged group; green tea supplementation aged group; exercise and green tea supplementation aged group. Interventions lasted 3 months composed by aerobic exercise and green tea, combined or not. Green tea was not effective in avoid cognitive deficits associated with aging, but significantly decreases ROS activity with significant improve in antioxidants defenses. Physical exercise improved all parameter in both biochemical and behavioral testing. The lack of effects of green tea on cognition may rely on the duration of the intervention, while decrease in the ROS suggests its effect role even during a short supplementation period.
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Asim, Mohammed. "Metabolism and bioactivity of catechins." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3774.

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Green tea is widely consumed worldwide, second only to water. Its health effects have been attributed to its polyphenolic catechin content, which accounts for a significant percentage of its dry weight. Epidemiological studies have observed beneficial health effects of green tea catechins against some cancers, cardiovascular diseases, and neurodegenerative diseases. However most studies have also been carried out in vitro where the concentrations of catechins used are not obtainable in the human body. The in vivo situation is very complicated and relies on favourable absorption, metabolism, and excretion of the catechins. In this thesis it is reported, the potential health benefits of green tea catechins in tissues which are highly and most often in contact with catechins, the oral cavity and the intestine. In experiments modelling the oral cavity the four major catechins were extensively absorbed into H400 cells, and showed significant protection at physiological concentrations against H2O2 induced mitochondrial DNA damage. Thereafter the in vitro metabolism of catechins were measured using various intestinal and liver enzyme fractions. It was shown, that in these systems, glucuronidation was the main metabolism pathway. These enzyme fractions also provided mixtures of metabolites which were used to measure their comparative bioactivities in relation to their parent compounds. This was done via the assessment of their protective effects against H2O2 induced mtDNA damage in human intestinal cells. The metabolites were shown to be significantly bioactive; however the majority of the metabolites had lower bioactivities than the parent compound. In the final study the aim was to inhibit the glucuronidation of catechins to aid in the development of strategies to enhance catechin bioavailability. The two compounds chosen have previously been shown to inhibit intestinal glucuronidation. In this study it was determined that both piperine and quercetin significantly inhibited the metabolism of the catechins in intestinal microsomes. These studies taken together give a platform for future studies to be carried out which will be more detailed and rigorous.
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Sheehan, James M. "The formation of catechists." Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.

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Wollersen, Heike. "Bestimmung und Identifizierung von Flavonoiden in Gerste mit HPLC-DAD-MS/MS." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971821453.

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Cheung, Bernice. "Historical catechisms in the modern church." Online full text .pdf document, available to Fuller patrons only, 2002. http://www.tren.com.

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Mochizuki, Manabu. "Electrochemical and spectroscopic analysis on the oxidation of catechins." Kyoto University, 2005. http://hdl.handle.net/2433/145449.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(農学)
甲第11239号
農博第1454号
新制||農||902(附属図書館)
学位論文||H17||N3984(農学部図書室)
22848
UT51-2004-U444
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 池田 篤治, 教授 關谷 次郎, 教授 大東 肇
学位規則第4条第1項該当
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Clarke, Kayleigh Anne. "Bioavailability and bioactivity of green tea catechins in skin." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/6354/.

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Dietary flavonoids have been extensively researched in relation to health benefits in humans. The regular consumption of green tea catechins (GTC) has been associated with a reduction in the risk of developing diabetes, cardiovascular disease and cancer. Flavonoids are known to protect plants from the damage caused by exposure to UV radiation, and this effect has also been observed when flavonoids are applied topically to human skin cells. The effect of oral consumption of flavonoids on skin protection from UV exposure is not clear. The work presented within this thesis aimed to investigate the effect of GTC on the response of skin cells to UV induced-stress. Keratinocyte cells from an immortalised human skin cell line (HaCaT) were assessed after exposure to various stress conditions in vitro (FBS starvation, hydrogen peroxide and UV), in combination with a pre-treatment of green tea extract or a purified mixture of GTC. GTC reduced cell death induced by stress (decrease in LDH release), and maintained viability (increase in MTT uptake) in HaCaT cells, relative to control treatments. The uptake of vitamin C, a photo-protective agent depleted after UV exposure, was enhanced by treatment with GTC during stress conditions, as monitored by uptake of 14C-dehydroascorbic acid and evaluation of vitamin C transporters with qRT-PCR. In relation to in vivo conditions, GTC may provide protection and also enhance vitamin C uptake into skin cells undergoing stress. Bioavailability of GTC and metabolites in human skin cells after daily consumption of green tea and vitamin C supplements for 3 months was also investigated. Catechin metabolites in a range of tissues (plasma, interstitial blister fluid, skin biopsies and urine) were identified with LC-MS-MS in unconjugated and conjugated (sulphate, methyl and glucuronide) forms. For the first time, conjugated catechin metabolites were identified in skin tissue samples and extracellular fluid surrounding skin cells; including M6/M6'-O-sulphate, O-methyl-EC-O-sulphate,EC-O-sulphate and EGC-O-glucuronide, with metabolites identified in urine and plasma post-consumption similar to data reported in the literature. The work presented in this thesis provides new knowledge on bioavailability of GTC and metabolites in human skin, which together with vitamin C, may exert UV protection and other health benefits. Further research is required in vitro using pure conjugated standards (methyl, glucuronide and sulphate moieties), and data corresponding to the inflammatory biomarkers post-UV exposure (analysis at the University of Manchester and University of Bradford) is also required before a conclusive relationship can be drawn between oral consumption of flavonoids and UV protection.
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McEvilly, Christine A. (Christine Ann). "Catechisms and cataclysms : communication in the Reformation." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/59489.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Humanities, Arts, and Social Sciences [SHASS], History Section, 2007.
Includes bibliographical references (leaves 87-88).
How does belief shape lived experience? This is a central question of existence that all people confront, be they philosophers or farmers. It is not simply a matter of religious belief but a problem that stems from the very core of what it means to be human. Who could decide how to spend their lives without defining priorities? Yet such profound choices are necessarily based on implicit beliefs, valuations of worth and existence. The Reformation period in early modem Europe shines a particularly bright light upon these fundamental questions. Once Martin Luther nailed his Thesis to the church door in Wittenberg in 1517, and in the religious turmoil of the sixteenth and seventeenth centuries that followed, no one could avoid considering basic questions about their faith, even if only to defend what had been the status quo. Furthermore, the personal beliefs of Martin Luther and his German princes became a subject that could change the political course of nations. It was in Martin Luther's crucible of religious turmoil that personal belief and government began to shape each other in drastic and visible ways, an interaction which not only emphasizes the importance of belief, but also highlights the problem of popular beliefs, which are difficult to discern in times of religious quietude. But why examine belief? Are there not other more visible expressions of historical change? Ultimately, history is about individuals. One can examine the great political and economic trends of nations, but they only have meaning as they relate to individual existence. What is a modern nation state, if not a collection of its citizens and of how they live, work, interact, and think? Examining the religious beliefs of a society allows one to look at thought and actions in those who were far removed from "high" intellectual culture; for the thoughts of those who composed the massive majority of European society cannot be ignored simply because they were not always expressed in easily retrieved written discourses. Luckily, since theologians, politicians, and activists tried to influence popular belief, their records can be examined. The methods used to influence belief and practice, suggest not only what was in fact believed, but also what topics were of central concern to society's dialogue on religious change. Belief can have power over forces and institutions far larger than any single believing individual. Indeed, the very idea that religion is an issue of concern to individuals and not defined at the level of a city or nation was a novel one in the early modem era. Not surprisingly, and such a fundamental change in the concept of the individual had widespread consequences. This work examines the transmission of reformation ideas from scholars and theologians to lay parishioners in both the Protestant and Catholic traditions. It considers how large scale revolutions in religious thought affected the lives, piety, and religious practice of ordinary individuals. Yet the examination of this theme of transmission and communication is ultimately just a small part of one of the questions that historians have debated: Can the Reformation period be seen as offering up a true division into two different religions, or should it be seen as a moment during which both Catholic and Protestant traditions modernized in parallel to each other? Of course, both views contain some elements of truth; both churches managed to modernize, but nevertheless had fundamental differences in both theology and practice. However, an equally vital question is, perhaps, whether the churches' interactions with society were characterized by the differences between them or by the similar, modern forms both churches shared. This work ultimately suggests that the differences that had developed between Catholic and Protestant traditions by the mid seventeenth century are dwarfed by the changes in both that converted medieval practice to a more modem system. These modem religious traditions would come to co-exist with modern nation states, evolving economic practice, re-defined communities, and the secularization of Europe. Similarities in Protestant and Catholic communication of new theology and reformed practice can be identified and traced, lending support to the theory of parallel reform with similar outcomes, particularly in terms of community and state, even if their respective theologies contained real differences. Communication provides a useful lens for examining this question of difference and modernization since it involves many elements of the two reformed traditions. The choice of what information was to be transmitted, suggests which new theologies the churches thought significant and which were important to the contentious dialogues of the period. The forms of communication speak to the regular functioning of the church as an organization, and suggest how authority figures interacted with their laity. The composition of the audience suggests the new community definitions of each church. This essay will examine three mediums for communicating the agenda of reform in the late sixteenth and early seventeenth centuries: architecture and visual art, education, and discipline and charity, insofar as they defined community ...
by Christine A. McEvilly.
S.B.
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Mehra, Anisha. "The effects of green tea derived catechins upon adipocyte metabolism." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/12115/.

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Tea, from the plant Camellia Sinensis, is after water, the most consumed drink in the world. Green tea, produced by steaming freshly harvested leaves to prevent fermentation, is high in polyphenols known as catechins or flavanols. The major flavanols found in green tea include (-) epigallocatechin-3-gallate (EGCG) and (-) epicatechin. Literature reports suggest that green tea flavanols have the potential to exert anti-obesity effects by modulating weight gain and other factors such as lipogenesis, β-oxidation and adipokine release. Key features of obesity and associated insulin resistance are adipokine dysregulation, decreased sensitivity of adipocytes to insulin and subsequently, changes in glucose uptake by cells. The aims of this thesis were firstly to establish an efficient system of differentiated adipocytes and secondly to use this to investigate the effects of the flavanols EGCG and epicatechin on physiological outcomes such as adipokine release and glucose uptake. Thirdly, the question of whether these processes might be regulated by the ERK1/2 pathway and what may be happening upstream of this was explored. Finally, the effect of flavanol treatment on adipocyte gene expression of genes known to be modulated in obesity was investigated. Using the well established cell culture model of 3T3-L1 adipocytes, the studies from this thesis show that EGCG and epicatechin are able to modulate the release of the adipokines adiponectin and resistin, dependent on the media glucose concentration. This modulation may be mediated by the ERK1/2 pathway, since flavanol treatment increased ERK1/2 phosphorylation. Uptake of glucose was not altered by any time or concentration of EGCG or epicatechin, and there were no significant changes in adipocyte gene expression following EGCG or epicatechin treatment. A thorough investigation of adipokine release, ERK signalling, glucose uptake and gene expression, under the influence of flavanol treatment, showed that although molecular changes occurred in the 3T3-L1 system, these did not translate into functional readouts. Therefore, it appears unlikely that these have major direct effects on adipocyte function.
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Books on the topic "Catechines"

1

Questions & answers for catechists. Mystic, Conn: Twenty-Third Publications, 1991.

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Classroom management for catechists. Liguori, MO: Liguori Publications, 2013.

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Hesch, John B. A primer for catechists. New York: Paulist Press, 1987.

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Peters, Albrecht. Commentary on Luther's catechisms. Edited by Schaum Charles P. St. Louis, MO: Concordia Pub. House, 2009.

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Reading catechisms, teaching religion. Leiden: Brill, 2015.

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Catholic social teaching. New London, Ct: Twenty-Third Publications, 2009.

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Ries, Peter. Catechists in formation: Program manual. Mission Hills, Calif: Benziger Pub. Co., 1995.

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Book of catechisms: Reference edition. Louisville, Ky: Geneva Press, 2001.

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J, Pfeifer Carl, ed. How creative catechists use stories. Mystic, CT: Twenty-Third Publications/Bayard, 2000.

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Seven secrets of successful catechists. Huntington, Ind: Our Sunday Visitor Pub. Div., 2002.

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Book chapters on the topic "Catechines"

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Baldi, Alessandra, Helena Abramovič, Nataša Poklar Ulrih, and Maria Daglia. "Tea Catechins." In Handbook of Dietary Phytochemicals, 1–46. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1745-3_19-1.

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Baldi, Alessandra, Helena Abramovič, Nataša Poklar Ulrih, and Maria Daglia. "Tea Catechins." In Handbook of Dietary Phytochemicals, 1–46. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-13-1745-3_19-2.

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Baldi, Alessandra, Helena Abramovič, Nataša Poklar Ulrih, and Maria Daglia. "Tea Catechins." In Handbook of Dietary Phytochemicals, 1–46. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-13-1745-3_19-3.

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Baldi, Alessandra, Helena Abramovič, Nataša Poklar Ulrih, and Maria Daglia. "Tea Catechins." In Handbook of Dietary Phytochemicals, 929–74. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-4148-3_19.

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Lunder, T. L. "Catechins of Green Tea." In ACS Symposium Series, 114–20. Washington, DC: American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0507.ch009.

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Oliveira, Joana, Nuno Mateus, and Victor de Freitas. "Flavanols: Catechins and Proanthocyanidins." In Natural Products, 1753–801. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_58.

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Ho, Chi-Tang, Nanqun Zhu, and Tzou-Chi Huang. "Oxidative Transformation of Tea Catechins." In ACS Symposium Series, 102–12. Washington, DC: American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0775.ch007.

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Ostrom, Thomas M. "Three Catechisms for Social Memory." In Memory: Interdisciplinary Approaches, 201–20. New York, NY: Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4612-3500-2_10.

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Kuroda, Yukiaki, and Yukihiko Hara. "Food and Industrial Applications of Tea Catechins." In Health Effects of Tea and Its Catechins, 93–98. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4757-5390-5_7.

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Lambert, Joshua D., and Chung S. Yang. "Cancer Prevention by Catechins, Flavonols, and Procyanidins." In Bioactive Compounds and Cancer, 613–31. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-627-6_26.

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Conference papers on the topic "Catechines"

1

Mello-Júnior, Ronaldo Elias, João Renato De Jesus Junqueira, Jefferson Luiz Gomes Corrêa, Kamilla Soares de Mendonça, and Lucas Barreto de Carvalho. "Osmotic dehydration of eggplant, carrot and beetroot slices: Effect of vacuum on phenolic acid composition." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7787.

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The aim of this work was to evaluate the influence of vacuum application on the phenolic acid content of osmodehydrated eggplant, carrot and beetroot samples. The contents of catechins and chlorogenic acid were determined by HPLC analysis. Changes in the contents of phenolic acids after the osmotic processes were observed. It was found a reduction in catechins and chlorogenic acids, probable due to the migration and degradation losses. In a general way, the vacuum reduced the catechin and chlorogenic acid contents, compared to the osmotic dehydration at atmospheric pressure. Keywords: Pulsed vacuum osmotic dehydration; chlorogenic acid; catechins.
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Yaneva, Zvezdelina, and Donika Ivanova. "CATECHIN HYDRATE DESORPTION FROM NEWLY-SYNTHESIZED CATECHIN-LOADED BIOPOLYMER PARTICLES." In RAD Conference. RAD Centre, 2020. http://dx.doi.org/10.21175/radproc.2020.21.

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Mulyani, Dwi, Gustri Yeni, and Devahimer Harsep Rosi1. "Evaluation of the solid soap quality from catechins." In Seminar Nasional 1 Baristand Industri Padang. Jakarta: Redwhite Press, 2020. http://dx.doi.org/10.32698/gcs-sniibipd3438.

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Chatterjee, Trisita Nandy, Runu Banerjee Roy, Bipan Tudu, Rajib Bandyopadhyay, Panchanan Pramanik, and Nabarun Bhattacharyya. "Voltammetric determination of catechins in green tea using stainless steel electrode." In 2016 International Conference on Intelligent Control Power and Instrumentation (ICICPI). IEEE, 2016. http://dx.doi.org/10.1109/icicpi.2016.7859686.

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Joniová, Jaroslava, and Georges Wagnières. "Photoprotective effect of catechin during ALA-PDT." In 17th International Photodynamic Association World Congress, edited by Tayyaba Hasan. SPIE, 2019. http://dx.doi.org/10.1117/12.2527278.

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Suming Chen, Sheng-Jie Luo, Yu-Liang Chen, Yung-Kun Chuang, Chao-Yin Tsai, I-Chang Yang, Chun-Chi Chen, Yao-Jen Tsai, Cheng-Hung Cheng, and Hsien-Tsung Tsai. "Spectral Imaging Approach to Evaluate Degree of Tea Fermentation by Total Catechins." In 2010 Pittsburgh, Pennsylvania, June 20 - June 23, 2010. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2010. http://dx.doi.org/10.13031/2013.29859.

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Cooper, Raymond, D. James Morre, and Dorothy M. Morre. "ENOX2 (tNOX), A Molecular Target for the Anticancer Activity of Green Tea Catechins." In Annual International Conferences on Advances in Cancer Medical Research. Global Science & Technology Forum (GSTF), 2014. http://dx.doi.org/10.5176/2345-7821_acmr14.07.

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Musdja, Muhammad Yanis, Lina Elvita, and Nursetyowati Rahayu. "Effects of Gambir (Uncaria gambir Roxb) Catechins on Burn Wound Healing in Male Rats." In Bromo Conference, Symposium on Natural Products and Biodiversity. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008361002610271.

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Lapi, D., M. Varanini, R. Scuri, and A. Colantuoni. "Effects of Catechin on cerebral arteriole vasomotion in spontaneously hypertensive rats." In 2020 11th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO). IEEE, 2020. http://dx.doi.org/10.1109/esgco49734.2020.9158049.

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Fujiki, Hirota, Tatsuro Watanabe, Atsushi Takahashi, and Masami Suganuma. "Abstract 168A: More effective therapy of cancer by the combination of anticancer drugs with green tea catechins." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-168a.

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