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Academic literature on the topic 'Catechines'
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Journal articles on the topic "Catechines"
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He, Hua-Feng, and Yang Ye. "Discrimination Based on Volatile Compounds and Differential Analysis of Chinese Dark Tea." Journal of Agricultural Science 8, no. 9 (2016): 115. http://dx.doi.org/10.5539/jas.v8n9p115.
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<p>Simultaneous distillion and extraction (SDE)/gas chromatographymass spectrometry (Gc-Ms) detection coupled with partial least squares-discriminate analysis (PLS-DA) were used to discriminate Chinese dark teas (CDTs). A total of 84 volatile compounds were taken to conduct the cluster analysis. 9 kinds of CDTs could be divided into 3 groups in consistent with the manufacturing processes. Besides, ingredients that were related with the quality of CDT, such as free amino acid, soluble sugar and catechines were analyzed. Differential trends were disclosed between Pu-Er raw tea and Pu-Er ripe tea as well as raw dark green tea (RDGT).</p>
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Rogovskii, Vladimir S., Sergey V. Popov, Nikolai V. Sturov, and Nikolai L. Shimanovskii. "The Possibility of Preventive and Therapeutic Use of Green Tea Catechins in Prostate Cancer." Anti-Cancer Agents in Medicinal Chemistry 19, no. 10 (2019): 1223–31. http://dx.doi.org/10.2174/1871520619666190404153058.
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Background:Prostate cancer is one of the most frequent types of cancer. Despite the existence of various treatment strategies, treatment of prostate cancer still presents serious difficulties (especially in advanced stages). Polyphenols have been extensively assessed in terms of their potential use for prostate cancer treatment and prevention. Catechins are among the most well-known polyphenols in this respect.Objective:In this review, we summarize clinical study results concerning catechin applications with regard to prostate cancer treatment and prevention. We discuss some of the main mechanisms of the anticarcinogenic action of catechins.Conclusion:The main mechanisms of the anticarcinogenic action of catechins are subdivided into two major types: (i) direct action on cancer cells and (ii) indirect effect based on catechins’s impact on the microenvironment of cancer cells, particularly in relation to the immune system. At this level catechins might reduce tumor-associated inflammation and immune tolerance.
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Markina, O. V., E. V. Maksimenko, N. V. Markin, et al. "STUDY OF COMPOSITION OF PLANT EXTRACTS, POSSESSING ANTIMICROBIAL EFFECT AGAINST VIBRIO CHOLERAE EL TOR, USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY." Journal of microbiology epidemiology immunobiology, no. 1 (February 28, 2016): 63–66. http://dx.doi.org/10.36233/0372-9311-2016-1-63-66.
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Aim. Study the composition of plant extracts using high-performance liquid chromatography (HPLC) and evaluation of their antimicrobial effect against Vibrio cholerae El Tor. Materials and methods. Qualitative and quantitative composition of plant extracts was studied using HPLC. Determination of sensitivity of microorganisms to plant extracts was carried out by diffusion into agar method and serial dilutions method. Results. Antibacterial effect of water, water-alcohol and acetone extracts of roots of Limonium gmelinii L., Berberis vulgaris L. and Glycyrrhiza glabra L. was studied. The most effective methods of extraction of biologically active substances, possessing antimicrobial effect against various strains of V.cholerae El Tor, were determined. Conclusion. The use of HPLC allowed to establish the presence of catechines, alkaloids protoberberines and glycyrrhizic acid in extracts, possessing antimicrobial effect against V.cholerae El Tor strains.
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Furushima, Daisuke, Takuma Nishimura, Norikata Takuma, et al. "Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial." Nutrients 12, no. 1 (2019): 4. http://dx.doi.org/10.3390/nu12010004.
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Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test, p = 0.042). The hazard ratio (95% confidence interval (CI)) with reference to the placebo group was 1.09 (0.61–1.92) in the low-catechin group and 0.46 (0.23–0.95) in the high-catechin group. These findings suggest that catechins combined with xanthan gum protect against URTIs.
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Naparlo, Katarzyna, Grzegorz Bartosz, Ireneusz Stefaniuk, Bogumil Cieniek, Miroslaw Soszynski, and Izabela Sadowska-Bartosz. "Interaction of Catechins with Human Erythrocytes." Molecules 25, no. 6 (2020): 1456. http://dx.doi.org/10.3390/molecules25061456.
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The aim of this study was to characterize the interaction of chosen catechins ((+)-catechin, (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG)) with human erythrocytes and their protective effects against oxidative damage of erythrocytes. Uptake of the catechins by erythrocytes was studied by fluorimetry, their interaction with erythrocyte membrane was probed by changes in erythrocyte osmotic fragility and in membrane fluidity evaluated with spin labels, while protection against oxidative damage was assessed by protection against hemolysis induced by permanganate and protection of erythrocyte membranes against lipid peroxidation and protein thiol group oxidation. Catechin uptake was similar for all the compounds studied. Accumulation of catechins in the erythrocyte membrane was demonstrated by the catechin-induced increase in osmotic resistance and rigidification of the erythrocyte membrane detected by spin labels 5-doxyl stearic acid and 16-doxyl stearic acid. (−)-Epigallocatechin and EGCG inhibited erythrocyte acetylcholinesterase (mixed-type inhibition). Catechins protected erythrocytes against permanganate-induced hemolysis, oxidation of erythrocyte protein thiol groups, as well as membrane lipid peroxidation. These results contribute to the knowledge of the beneficial effects of catechins present in plant-derived food and beverages.
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Sasaki, Geoffrey, Yael Vodovotz, Zhongtang Yu, and Richard Bruno. "Catechin Bioavailability Is Reduced in Obese Persons Without Altering Gut Microbial-Derived Valerolactones Following Consumption of a Green Tea Extract Confection." Current Developments in Nutrition 4, Supplement_2 (2020): 468. http://dx.doi.org/10.1093/cdn/nzaa045_101.
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Abstract Objectives Green tea extract (GTE) protects against obesity in rodents by reducing gut permeability that otherwise provokes endotoxemia-mediated inflammation. However, whether obesity affects catechin bioavailability and microbial metabolism is unknown. We hypothesized that obesity will reduce catechin bioavailability by increasing microbial biotransformation of catechins. Methods Obese persons (n = 10 M/7F; 33.5 ± 0.7 kg/m2) and age-matched healthy persons (n = 10 M/9F; 21.7 ± 0.4 kg/m2) completed a pharmacokinetics (PK) trial in which a GTE confection [290 mg epigallocatechin gallate (EGCG), 87 mg epigallocatechin (EGC), 39 mg epicatechin (EC), 28 mg epicatechin gallate (ECG)] was ingested prior to collecting plasma at 0, 0.25, 0.5, 1, 2, 3, 5, 8, 10, and 12 h and urine from 0–4, 4–8, 8–12, and 12–24 h. Stool samples were collected and gut permeability was assessed prior to the 12-h PK trial. Plasma and urinary catechin/catechin-derived microbial metabolites were assessed following enzymatic hydrolysis by LC-MS. Results Regardless of health status, relative bioavailability, based on plasma area under the curve (AUC0–12 h), of GTE catechins were: EGCG &gt; EGC &gt; ECG &gt; EC. However, obese persons had 24–27% lower plasma AUC0–12 h for the four catechins compared to lean persons (P &lt; 0.05). They also had 18–36% lower maximum plasma concentrations (Cmax) of GTE catechins but 12 h plasma catechin concentrations were unaffected by obesity status (P &gt; 0.05). 3ʹ,4ʹ-γ-valerolactone (3,4-VL) was detected in the plasma of all participants, while 3ʹ,4ʹ,5ʹ-γ-valerolactone (3,4,5-VL) was detected in 74% and 82% of lean and obese persons, respectively. Plasma AUC0–12 h for these VL metabolites did not differ by obesity status. EGC, EC, 3,4-VL, and 3,4,5-VL, but not EGCG and ECG, were primarily present in urine and urinary total VLs were increased compared with total urinary catechins. However, 24-h urinary excretion of catechins and VLs were unaffected by obesity. Conclusions Obesity reduces GTE catechin bioavailability and Cmax independent of any change in VL metabolite appearance or urinary elimination of catechins, suggesting a gut-level mechanism that limits catechin absorption. Funding Sources Supported by USDA-NIFA and the Foods for Health Discovery Theme at The Ohio State University.
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Ai, Zeyi, Shuyuan Liu, Fengfeng Qu, Haojie Zhang, Yuqiong Chen, and Dejiang Ni. "Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers." Molecules 24, no. 6 (2019): 1185. http://dx.doi.org/10.3390/molecules24061185.
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The transcellular transport and metabolism of eight green tea catechins (GTCs) were studied in Caco-2 monolayers, with the aim of investigating the effect of cis–trans isomerism on the membrane permeability and biotransformation of GTCs. The results showed that the catechin stereochemistry significantly affects the efflux transport rather than the absorption transport in the Caco-2 monolayers. The trans catechins showed a better transcellular permeability than their corresponding cis (epi) catechins in the efflux transport, as the efflux amount of trans catechins were all significantly higher than that of the cis (epi) catechins at each concentration and each time point tested. Moreover, the relative contents of the (+)-catechin (C)-O-sulfate, (+)-gallocatechin (GC)-O-sulfate, (−)-catechin gallate (CG)-O-sulfate, and (−)-gallocatechin gallate (GCG)-O-sulfate in the efflux transport were 2.67, 16.08, 50.48, and 31.54 times higher than that of the (−)-epicatechin (EC)-O-sulfate, (−)-epigallocatechin (EGC)-O-sulfate, (−)-epicatechin gallate (ECG)-O-sulfate, and (−)-epigallocatechin gallate (EGCG)-O-sulfate, respectively. It indicated that more metabolites were observed after the transcellular efflux of trans catechins. Furthermore, after two hours of incubation, the GTCs could significantly increase the expression of multidrug resistance-associated protein 2 (MRP2) and breast cancer-resistance protein (BCRP), and decrease the expression of P-glycoprotein in the Caco-2 cells. The regulation of GTCs on P-glycoprotein, MRP2, and BCRP could also be significantly influenced by the chemical and dimensional structure. In a conclusion, catechin stereochemistry significantly affects the transport and metabolism of GTCs when refluxed in the Caco-2 monolayers.
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Furushima, Daisuke, Yu Otake, Natsumi Koike, et al. "Investigation of the Oral Retention of Tea Catechins in Humans: An Exploratory Interventional Study." Nutrients 13, no. 9 (2021): 3024. http://dx.doi.org/10.3390/nu13093024.
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Green tea catechin ingestion or gargling exhibit anti-viral activity against upper respiratory infection. We hypothesized that retention in the oral cavity could improve the anti-viral effects of catechins. The present study investigated the oral retention of catechins in humans and the effect of catechin beverage viscosity on oral retention. Two intervention studies with different test beverages, beverage-C (40 mL, containing 73.4 mg of catechins) and beverage-XT (40 mL, beverage-C containing 100 mg xanthan gum) were conducted in 20 healthy volunteers (mean age 38.7 years). Catechin concentrations were measured in buccal mucosa samples collected at 10 min, 40 min, and 60 min after ingesting test beverages, and the catechin variability of the tissue after intake was compared between test beverages. As a result, the mean (SEM) concentrations of EGCG were 99.9 (27.2), 58.2 (16.6), and 22.3 (5.7) ng/mg-mucosa at 10, 40, and 60 min, respectively, after ingestion of beverage-XT. Similarly, the catechin concentrations were 86.1 (20.3), 32.2 (5.3), and 27.8 (5.9) ng/mg-mucosa after ingestion of beverage-C. The total retention volume over 60 min tended to be slightly higher after ingestion of beverage-XT, though the difference was not statistically significant. Additional studies are needed to confirm the effect of xanthan gum on improving oral retention of catechins.
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Mohd Zin, Zamzahaila, Nursyafiqah Mohamad, Chong Kah Hui, Nurul Izwanie Majid, and Mohd Khairi Zainol. "Effect of Acidified Ethanol on Antioxidant Properties of Morinda citrifolia Leaf Extract and Its Catechin Derivatives." Current Research in Nutrition and Food Science Journal 9, no. 1 (2021): 172–83. http://dx.doi.org/10.12944/crnfsj.9.1.17.
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This study was conducted to investigate the effect of ethanol acidification on the antioxidant properties of Morinda citrifolia leaf (MCL) extract and its catechin derivatives. Four different ethanol (100%, 99.5%, 70%, 50%) with or without 0.5% acetic acid were used for extraction. The antioxidant profile was studied with DPPH radical scavenging activity, FRAP and TPC. The quantification of catechins in MCL was performed using HPLC, and the identification of catechins derivatives was performed with Ultra UPLC-TWIMS-QTOF. The results showed that an extraction solvent composed of 70% ethanol: 29.5% water: 0.5 % acetic acid exhibited the highest DPPH percentage of inhibition (86.12±2.96%) and highest TPC value with 97.80±0.25 mg GAE/g extract, while 100% ethanol acidified with 0.5% acetic acid showed highest FRAP antioxidant power with 1.31±0.05mg FSE/g extract. All eight types of catechins were identified in MCL and the most total catechins were quantified in 70% ethanol: 29.5% water: 0.5 % acetic acid at 153.57mg/g. The catechin derivatives identified included epigallocatechin-3-O-gallate (EGCG), epigallocatechin (4β, 8)-gallocatechin, gallocatechin (4α→8)-epicatechin, catechin-3-O-gallate (CG) and epigallocatechin (EGC). The results suggest that acidification improves the extraction of polyphenols as well as catechin content.
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Zheng, Kaiwen, Kai Guo, Jing Xu, et al. "Study on the interaction between catechin and cholesterol by the density functional theory." Open Chemistry 18, no. 1 (2020): 357–68. http://dx.doi.org/10.1515/chem-2020-0038.
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AbstractCatechin – a natural polyphenol substance – has excellent antioxidant properties for the treatment of diseases, especially for cholesterol lowering. Catechin can reduce cholesterol content in micelles by forming insoluble precipitation with cholesterol, thereby reducing the absorption of cholesterol in the intestine. In this study, to better understand the molecular mechanism of catechin and cholesterol, we studied the interaction between typical catechins and cholesterol by the density functional theory. Results show that the adsorption energies between the four catechins and cholesterol are obviously stronger than that of cholesterol themselves, indicating that catechin has an advantage in reducing cholesterol micelle formation. Moreover, it is found that the molecular interactions of the complexes are mainly due to charge transfer of the aromatic rings of the catechins as well as the hydrogen bond interactions. Unlike the intuitive understanding of a complex formed by hydrogen bond interaction, which is positively correlated with the number of hydrogen bonds, the most stable complexes (epicatechin–cholesterol or epigallocatechin–cholesterol) have only one but stronger hydrogen bond, due to charge transfer of the aromatic rings of catechins.