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1

Wang, Wenping, Ximing Wu, Chung S. Yang, and Jinsong Zhang. "An Unrecognized Fundamental Relationship between Neurotransmitters: Glutamate Protects against Catecholamine Oxidation." Antioxidants 10, no. 10 (2021): 1564. http://dx.doi.org/10.3390/antiox10101564.

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Neurotransmitter catecholamines (dopamine, epinephrine, and norepinephrine) are liable to undergo oxidation, which copper is deeply involved in. Catecholamine oxidation-derived neurotoxicity is recognized as a pivotal pathological mechanism in neurodegenerative diseases. Glutamate, as an excitatory neurotransmitter, is enriched in the brain at extremely high concentrations. However, the chemical biology relationship of these two classes of neurotransmitters remains largely unknown. In the present study, we assessed the influences of glutamate on the autoxidation of catecholamines, the copper-
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2

Padbury, J. F., A. M. Martinez, S. L. Thio, E. E. Burnell, and J. A. Humme. "Free and sulfoconjugated catecholamine responses to hypoxia in fetal sheep." American Journal of Physiology-Endocrinology and Metabolism 257, no. 2 (1989): E198—E202. http://dx.doi.org/10.1152/ajpendo.1989.257.2.e198.

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Plasma catecholamines circulate either in conjugated or unconjugated forms. In adult humans, sulfoconjugated catecholamines predominate; however, there is considerable variation between species. In a variety of pathophysiological states catecholamine conjugation is believed to represent an important mechanism of inactivation of high circulating catecholamine levels. To date, there have been few data in developing animals or humans on catecholamine sulfoconjugation. We studied the differences in free and sulfoconjugated catecholamines in full term (141 +/- 1 days) and preterm (123 +/- 1 days) c
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3

Koller, M. "Results for 74 substances tested for interference with determination of plasma catecholamines by "high-performance" liquid chromatography with electrochemical detection." Clinical Chemistry 34, no. 5 (1988): 947–49. http://dx.doi.org/10.1093/clinchem/34.5.947.

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Abstract Various catecholamine metabolites, catecholamine-related compounds, catechols, drugs, amines, and other nitrogen compounds were injected onto an HPLC system ("ClinRep Catecholamine-Plasma" assay kit with a reversed-phase C18 column) used for measuring catecholamines. None of the 74 substances tested co-eluted with any of the catecholamines--norepinephrine, epinephrine, or dopamine--or with the internal standard, 3,4-dihydroxybenzylamine.
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4

Stein, H. M., A. Martinez, K. Oyama, L. Blount, and J. F. Padbury. "Effect of corticosteroids on free and sulfoconjugated catecholamines at birth in premature newborn sheep." American Journal of Physiology-Endocrinology and Metabolism 268, no. 1 (1995): E28—E32. http://dx.doi.org/10.1152/ajpendo.1995.268.1.e28.

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We previously demonstrated that prenatal corticosteroids attenuated the expected exponential increase in circulating catecholamines at birth. The present studies were undertaken to determine if alteration in sulfoconjugation could account for this attenuation. Catheterized fetal lambs received saline (n = 6) or corticosteroids (n = 8) intravenously for 60 h. The lambs were delivered by cesarean section at 130 +/- 1 days gestation. Ventilatory and cardiovascular responses and plasma catecholamine concentrations were measured for 2 h after birth. Although plasma free catecholamines levels were h
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5

Davidson, D. Fraser. "Phaeochromocytoma with Normal Urinary Catecholamines: The Potential Value of Urinary Free Metadrenalines." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 39, no. 6 (2002): 557–66. http://dx.doi.org/10.1177/000456320203900603.

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Background Normal urine catecholamine values in patients with phaeochromocytoma is an occasional finding and may lead to a missed diagnosis. Additional urinary free metadrenaline analysis may be of value in this situation. Methods In addition to vanillylmandelic acid, homovanillic acid and the catecholamines, urinary free normetadrenaline (fNMA) and free metadrenaline (fMA) were measured. This report describes six confirmed cases of phaeochromocytoma showing normal urinary catecholamine output and compares fMA results and tumour size with other confirmed cases where the urine catecholamines we
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6

Rosano, T. G., T. A. Swift, and L. W. Hayes. "Advances in catecholamine and metabolite measurements for diagnosis of pheochromocytoma." Clinical Chemistry 37, no. 10 (1991): 1854–67. http://dx.doi.org/10.1093/clinchem/37.10.1854.

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Abstract Assessment of catecholamine production and excretion is important in the laboratory detection of pheochromocytoma, a rare but curable cause of hypertension. Advances in catecholamine and metabolite methodologies have enhanced the diagnostic acumen by increasing analytical sensitivity and eliminating many of the interferences observed with earlier methods. Estimation of urinary catecholamines metanephrine and vanillylmandelic acid is routinely used in the biochemical detection of pheochromocytoma and in monitoring the completeness of tumor excision as well as the possibility of recurre
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7

Zhao, Lin, Xiaoran Zhang, Xu Meng, et al. "The Clinical Characteristics of Pheochromocytomas and Paragangliomas with Negative Catecholamines." Journal of Clinical Medicine 11, no. 19 (2022): 5583. http://dx.doi.org/10.3390/jcm11195583.

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Pheochromocytomas and paragangliomas (PPGLs) associated with negative catecholamines are not uncommon. However, few studies have examined clinical features of patients with these tumors. In the absence of available data, it is difficult to identify characteristics of patients with potential PPGLs and normal serum and urine screens. Therefore, an analysis of patients with PPGLs was conducted retrospectively to compare the clinical features of patients with positive and negative catecholamines. This study included 214 patients, including 69 patients with negative catecholamines. Prevalence rates
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8

Oyama, K., J. Padbury, A. Martinez, et al. "Free and sulfoconjugated catecholamine responses at birth in newborn sheep." American Journal of Physiology-Endocrinology and Metabolism 263, no. 1 (1992): E23—E27. http://dx.doi.org/10.1152/ajpendo.1992.263.1.e23.

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There have been little data on catecholamine sulfoconjugation in developing animals or humans. We studied the differences in free and sulfoconjugated catecholamines at birth in newborn sheep. Baseline concentrations of sulfoconjugated norepinephrine and epinephrine were the predominant form of circulating catecholamine, representing 77 +/- 4 and 65 +/- 12% of total circulating catecholamines, respectively. At birth the free epinephrine concentration increased 10-fold (49 +/- 27 to 653 +/- 21 pg/ml, respectively), and plasma free norepinephrine concentration rose 4-fold (307 +/- 92 to 1,178 +/-
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9

Waele, Jean-Pascal De, Michel Anctil, and Mats Carlberg. "Biogenic catecholamines in the cnidarian Renilla köllikeri: radioenzymatic and chromatographic detection." Canadian Journal of Zoology 65, no. 10 (1987): 2458–65. http://dx.doi.org/10.1139/z87-371.

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The presence of biogenic catecholamines in the colonial anthozoan Renilla köllikeri was assessed with a radioenzymatic assay and thin-layer chromatographic separation of extracts from different parts of the colony. Confirmation of catecholamine detection was also obtained using an HPLC technique with electrochemical detection. All three catecholamines, i.e., dopamine, noradrenaline, and adrenaline, were detected to varying degrees in the colonial compartments. Unidentified inhibitory factor(s) endogenous to Renilla tissues prevented the detection of internal catecholamine standards to an exten
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10

Fazio, Francesco, Marina Basova, and Osman Sabri Kesbiç. "Anthropogenic Pollution-Induced Stress: Catecholamine Deposition in Erythrocytes of Scorpaena porcus Linnaeus 1758." Croatian Journal of Fisheries 82, no. 3 (2024): 85–90. http://dx.doi.org/10.2478/cjf-2024-0011.

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Abstract The sympathoadrenal system plays an essential role in forming the body’s response to the action of stimuli of various natures and intensities. The content of deposited catecholamines in peripheral blood erythrocytes is one of the most accessible parameters for an adequate description of the functional activity of the sympathoadrenal system in humans and rats. The aim of the work is to assess the accumulation of catecholamines in erythrocytes of sea ruffs Scorpaena porcus L. at various pollution levels in the bays of Sevastopol. The phenomenon of accumulation of catecholamines in eryth
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11

Kjeldsen, S. E., K. Gjesdal, P. Leren, and I. K. Eide. "Decreased Platelet-Free Dopamine and Unchanged Noradrenaline and Adrenaline in Essential Hypertension." Thrombosis and Haemostasis 60, no. 02 (1988): 251–54. http://dx.doi.org/10.1055/s-0038-1647040.

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SummaryThe content of free-catecholamines in blood platelets is much higher than in plasma and platelet catecholamines must be taken up from plasma, since platelets lack the enzymes for catecholamine synthesis. There is some evidence that platelet catecholamine content under certain circumstances may be an integrated measure of plasma catecholamine concentrations over time. Platelet-free catecholamines were therefore assayed in 18 untreated patients with essential hypertension and in 16 normotensive control subjects. Mean platelet-free dopamine in the hypertensive group was 3.7 ± 0.4 pg/mg pla
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12

Shou, Jialong, Shuwang Zhan, Yi Zhang, Bo Liang, and Lu Fang. "Study on Catecholamine Sensors Based on Noble Metal Nanoparticles Modified Ti3C2 Mxene." Journal of Physics: Conference Series 2500, no. 1 (2023): 012002. http://dx.doi.org/10.1088/1742-6596/2500/1/012002.

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Abstract Catecholamines are neurotransmitters in the peripheral and central nervous systems, which maintain the normal physiological state of the human body. Studies have shown that the occurrence of many diseases are often accompanied by changes in catecholamine levels. Clinically, the detection of catecholamine levels in human plasma or urine can assist in the diagnosis of endocrine-related diseases and neurological diseases. However, catecholamines are easily oxidized, and the content in human body is very low. So the rapid detection of catecholamines is very important for the prevention an
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13

Bhattacharya, Arnab. "Bridging the Gap: Understanding the Significance of Catecholamines in Neurochemistry and Recent Advances in their Detection." Science Reviews - Biology 2, no. 1 (2023): 20–26. http://dx.doi.org/10.57098/scirevs.biology.2.1.3.

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The neurochemistry of catecholamines plays a crucial and complex role in human memory, behavior, and cognition, while affecting other organs such as the lungs, heart, liver, and skin. Dopamine, norepinephrine, and epinephrine are three closely-related catecholamines that have been widely studied over the last seven decades for development of medications for life-threatening diseases. Other studies have also suggested a link between drug abuse and catecholamine levels. The determination of catecholamine levels in different parts of the human body has also been a hot topic for research in these
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14

Meijer, Wim G., Sjef C. V. M. Copray, Harry Hollema, et al. "Catecholamine-Synthesizing Enzymes in Carcinoid Tumors and Pheochromocytomas." Clinical Chemistry 49, no. 4 (2003): 586–93. http://dx.doi.org/10.1373/49.4.586.

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Abstract Background: Serotonin is the principal endocrine product of carcinoid tumors, but simultaneously increased production of catecholamines has been described in these tumors. As it is not clear whether these tumors contain specific enzymes for catecholamine synthesis, we aimed to detect catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PNMT)] in midgut carcinoid tumors and pheochromocytoma and to correlate enzyme expression to serotonin production as well as catecholamines and metabolites excreted in u
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15

Boutilier, R. G., G. K. Iwama, and D. J. Randall. "The promotion of catecholamine release in rainbow trout, Salmo gairdneri, by acute acidosis: interactions between red cell pH and haemoglobin oxygen-carrying capacity." Journal of Experimental Biology 123, no. 1 (1986): 145–57. http://dx.doi.org/10.1242/jeb.123.1.145.

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A fall in blood pH was generated either by infusion of HCl or by reducing gill ventilation and raising blood PCO2 in rainbow trout, Salmo gairdneri Richardson. The acute acidosis resulting from HCl infusion caused an increase in plasma adrenaline and noradrenaline concentrations, the adrenaline increase being proportional to the decrease in blood pH. Fish subjected to a prolonged respiratory acidosis, caused by a reduction in gill ventilation, showed no increase in catecholamines 24 h after the change in gill ventilation. We suggest that catecholamine levels increase in response to a pH decrea
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16

Kido, Kazuhiko, and Maya Guglin. "Drug-Induced Takotsubo Cardiomyopathy." Journal of Cardiovascular Pharmacology and Therapeutics 22, no. 6 (2017): 552–63. http://dx.doi.org/10.1177/1074248417708618.

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Background: The most plausible hypothesis for takotsubo cardiomyopathy (TCM) is a catecholamine surge. Direct administration of catecholamines or medications causing catecholamine surge is frequently used in clinical practice. Methods: A Medline/PubMed database search was conducted for case reports or series of drug-induced TCM. All reported cases of drug-induced TCM were systemically identified and analyzed. Results: We identified 157 cases of drug-induced TCM. Fifty-seven (36.3%) cases were related to the administration of exogenous catecholamines. In 50 (31.9%) other cases, there was potent
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17

Romain, Yveline, Sylvain Demassieux, Giovanni D'Angelo, Martin Gyger, and Serge Carrière. "Is the platelet phenolsulfotransferase involved in the sulfoconjugation of plasma catecholamines?" Canadian Journal of Physiology and Pharmacology 64, no. 9 (1986): 1197–201. http://dx.doi.org/10.1139/y86-203.

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Catecholamines are predominantly present in the sulfoconjugated forms in human plasma. Phenolsulfotransferase (EC 2.8.2.1), which catalyses the sulfation of phenolic compounds, is widely distributed in human tissues. In blood, a phenolsulfotransferase, more specific for catecholamine sulfation is found exclusively in platelets. Free and sulfoconjugated catecholamines were measured in plasma and platelets of healthy volunteers and compared with those present in patients with uremia or pheochromocytoma to determine the ability of platelet phenolsulfotransferase to sulfurylate plasma catecholamin
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18

Cuche, J. L., F. Selz, G. Ruget, M. Gentil, and C. Gaudin. "Dilution of plasma with Tris buffer increases measured catecholamines in plasma." Clinical Chemistry 33, no. 3 (1987): 408–11. http://dx.doi.org/10.1093/clinchem/33.3.408.

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Abstract We investigated the effects of dilution of plasma samples on the measured concentrations of catecholamines. Diluting samples of human plasma 10-, 50-, and 100-fold with Tris buffer (100 mol/L, pH 8.6) improved analytical recovery of internal standards, suggesting that it decreases the commonly observed inhibition of methylation in radioenzymatic assays of catecholamines in plasma. However, the dilution is not associated with a proportional decrease in counted radioactivity. This extra amount of radioactivity, which is unlikely to be nonspecific in origin, accounts for a significant in
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19

AOTA, S., K. D. HOLMGREN, P. GALLAUGHER, and D. J. RANDALL. "A Possible Role for Catecholamines in the Ventilatory Responses Associated with Internal Aciosis or External Hypoxia in Rainbow Trout Oncorhynchus Mykiss." Journal of Experimental Biology 151, no. 1 (1990): 57–70. http://dx.doi.org/10.1242/jeb.151.1.57.

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Plasma catecholamine levels and gill ventilation were measured in rainbow trout (Oncorhynchus mykiss) during acidosis and hypoxia. There was an increase in both plasma catecholamines and ventilation correlated with the acidosis. Fish exposed to hyperoxia prior to acid infusion did not show significant changes in catecholamines or ventilation. Those treated with the β-adrenergic antagonist propranolol before acidosis showed increases in catecholamines but not ventilation. Hypoxia was also associated with increases in endogenous catecholamines and ventilation, and the increase in ventilation cou
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20

Hugh, D., A. Grennan, M. A. Abugila, and C. Weinkove. "Ascorbic acid as an antioxidant in measurements of catecholamines in plasma." Clinical Chemistry 33, no. 4 (1987): 569–71. http://dx.doi.org/10.1093/clinchem/33.4.569.

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Abstract Sodium metabisulfite, commonly used to prevent the oxidation of catecholamines during extraction from plasma onto alkaline alumina, does not prevent their subsequent degradation in acetic acid eluates. However, ascorbic acid, a potent antioxidant, is extracted with the catecholamines onto the alumina and prevents such destruction. However, ascorbic acid may interfere with the electrochemical measurement of catecholamines, unless sequential oxidation and reduction are used. Other methods of minimizing catecholamine oxidation in acetic acid eluates include refrigerating at 4 degrees C a
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21

Mpekoulis, George, Vassilina Tsopela, Georgios Panos, et al. "Association of Hepatitis C Virus Replication with the Catecholamine Biosynthetic Pathway." Viruses 13, no. 11 (2021): 2139. http://dx.doi.org/10.3390/v13112139.

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A bidirectional negative relationship between Hepatitis C virus (HCV) replication and gene expression of the catecholamine biosynthetic enzyme L-Dopa decarboxylase (DDC) was previously shown in the liver and attributed at least to an association of DDC with phosphatidylinositol 3-kinase (PI3K). Here, we report that the biosynthesis and uptake of catecholamines restrict HCV replication in hepatocytes, while HCV has developed ways to reduce catecholamine production. By employing gene silencing, chemical inhibition or induction of the catecholamine biosynthetic and metabolic enzymes and transport
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22

Eisenhofer, G., D. S. Goldstein, R. Stull, et al. "Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase." Clinical Chemistry 32, no. 11 (1986): 2030–33. http://dx.doi.org/10.1093/clinchem/32.11.2030.

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Abstract This is a reversed-phase liquid-chromatographic method, with electrochemical detection, for simultaneously measuring, in plasma, the concentrations of the catecholamine precursor dihydroxyphenylalanine (DOPA); the endogenous catecholamines norepinephrine, epinephrine, and dopamine; and the deaminated catecholamine metabolites dihydroxyphenylacetic acid (DOPAC) and dihydroxyphenylglycol (DHPG). We used this method to assess effects of monoamine oxidase (EC 1.4.3.4) inhibition in humans. Plasma DHPG concentrations as determined by the present method (mean 826, SEM 61 ng/L) were similar
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23

Mahata, Sushil K., Hong Zheng, Sumana Mahata, Xuefei Liu, and Kaushik P. Patel. "Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells." Journal of Endocrinology 230, no. 3 (2016): 309–23. http://dx.doi.org/10.1530/joe-16-0146.

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One of the key mechanisms involved in sympathoexcitation in chronic heart failure (HF) is the activation of the adrenal glands. Impact of the elevated catecholamines on the hemodynamic parameters has been previously demonstrated. However, studies linking the structural effects of such overactivation with secretory performance and cell metabolism in the adrenomedullary chromaffin cells in vivo have not been previously reported. In this study, HF was induced in male Sprague-Dawley rats by ligation of the left coronary artery. Five weeks after surgery, cardiac function was assessed by ventricular
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24

Li, Jun, Barbara A. French, Paul Fu, Fawzia Bardag-Gorce, and Samuel W. French. "Mechanism of the alcohol cyclic pattern: role of catecholamines." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 2 (2003): G442—G448. http://dx.doi.org/10.1152/ajpgi.00093.2003.

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The cause of the urinary alcohol level (UAL) cycle in rats fed ethanol at a constant rate has been shown to involve the hypothalamic-pituitary thyroid axis. Because the effect of thyroid hormone on the metabolic rate is augmented by catecholamines, the role of catecholamines was investigated by using the intragastric ethanol feeding model of alcoholic liver disease in which the UAL cycles over a 6- to 10-day period. The diet was supplemented with ephedrine and caffeine to test the hypothesis that the UAL cycle involves catecholamines. The UAL was followed to see whether the cycle was ablated b
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25

Eisenhofer, Graeme, Peter Friberg, Karel Pacak, et al. "Plasma Metadrenalines: Do they Provide Useful Information about Sympatho-Adrenal Function and Catecholamine Metabolism?" Clinical Science 88, no. 5 (1995): 533–42. http://dx.doi.org/10.1042/cs0880533.

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1. The clinical utility of plasma metadrenalines for examination of sympatho-adrenal function and catecholamine metabolism was assessed from plasma measurements of these metabolites in a number of clinical conditions (hypertension, cardiac failure, bilateral adrenalectomy and X-chromosomal deletions of the gene for monoamine oxidase), and before and during activation of sympathetic outflow or infusions of noradrenaline and adrenaline. 2. Plasma concentrations of normetadrenaline were less than 25% of those of noradrenaline, concentrations of metadrenaline and adrenaline were similar and those
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Foucart, Sylvain, Jacques de Champlain та Réginald Nadeau. "In vivo interactions between prejunctional α2- and β2-adrenoceptors at the level of the adrenal medulla". Canadian Journal of Physiology and Pharmacology 66, № 10 (1988): 1340–43. http://dx.doi.org/10.1139/y88-219.

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The combined effect of a β2-antagonist and an α2-agonist on the release of adrenal catecholamines was studied in the anaesthetized and vagotomized dog. The electrical stimulation of the splanchnic nerve (5-V pulses of 2 ms duration for 3 min at a frequency of 3 Hz) produced a significant rise in adrenal catecholamine release in the adrenal vein. Intravenous injection of a β2-antagonist significantly reduced this response and a subsequent injection of an α2-agonist further reduced the release of catecholamines. However, if the α2-agonist is injected first, the release is not different compared
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27

Aurich, Jörg E., Ina Dobrinski, Annette Petersen, Eberhard Grunert, Wolf-Dieter Rausch, and Wing W. Chan. "Influence of labor and neonatal hypoxia on sympathoadrenal activation and methionine enkephalin release in calves." American Journal of Veterinary Research 54, no. 8 (1993): 1333–38. http://dx.doi.org/10.2460/ajvr.1993.54.08.1333.

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Summary Labor and delivery stimulate increased release of catecholamines and endogenous opioid peptides in neonates. Catecholamines promote adaptation to the extrauterine environment after birth. Enkephalins are stored together with catecholamines in the adrenal medulla and have an inhibitory effect on catecholamine release. We investigated the influence of labor and neonatal hypoxia on epinephrine, norepinephrine, and met-enkephalin release in calves. Blood samples were taken from the umbilical artery before rupture of the umbilical cord and from the jugular vein repeatedly after birth. Highe
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Perry, S. F., R. Fritsche, and S. Thomas. "STORAGE AND RELEASE OF CATECHOLAMINES FROM THE CHROMAFFIN TISSUE OF THE ATLANTIC HAGFISH MYXINE GLUTINOSA." Journal of Experimental Biology 183, no. 1 (1993): 165–84. http://dx.doi.org/10.1242/jeb.183.1.165.

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A variety of in vivo and in situ experiments were performed on the Atlantic hagfish (Myxine glutinosa) (i) to characterize the levels of circulating catecholamines during acute stresses, including hypoxia, anoxia or physical disturbance (air-exposure), and (ii) to evaluate the potential mechanisms of catecholamine release from the major sites of storage, the systemic heart and posterior cardinal vein (PCV). Adrenaline and noradrenaline were stored at roughly equivalent concentrations (approximately 20 microgram g-1) in cardiac tissue, whereas noradrenaline was the predominant catecholamine sto
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29

Owen, N. E. "Effect of catecholamines on Na/H exchange in vascular smooth muscle cells." Journal of Cell Biology 103, no. 5 (1986): 2053–60. http://dx.doi.org/10.1083/jcb.103.5.2053.

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Catecholamines were found to activate Na/H exchange in a concentration-dependent manner in primary cultures of vascular smooth muscle cells (VSMC). The potency order was found to be epinephrine greater than norepinephrine greater than isoproterenol. The major pathway for catecholamine effects appeared to be via interaction with an alpha 1 adrenergic receptor. In addition, it was found that alpha 1 receptor-mediated Na/H exchange in VSMC was increased by angiotensin II and inhibited by 12-O-tetradecanoyl phorbol-13-acetate (TPA). Adrenergic receptors have been shown to be coupled to both adenyl
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Smith, Stephanie A., Janette Nason, and Roger P. Croll. "Distribution of catecholamines in the sea scallop, Placopecten magellanicus." Canadian Journal of Zoology 76, no. 7 (1998): 1254–62. http://dx.doi.org/10.1139/z98-063.

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Catecholamines have previously been implicated in several important physiological processes in molluscs, including reproduction, respiration, and feeding. Much of the previous research has relied upon high-performance liquid chromatography to identify and quantify the various catecholamines and pharmacological experiments to investigate their actions. In the present report, we expand upon these studies by using histochemical techniques to investigate the distribution of catecholamine-containing cells and fibres in the central nervous system and peripheral tissues of the sea scallop, Placopecte
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31

Kolberg, K. J., and V. J. Martin. "Morphological, cytochemical and neuropharmacological evidence for the presence of catecholamines in hydrozoan planulae." Development 103, no. 2 (1988): 249–58. http://dx.doi.org/10.1242/dev.103.2.249.

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Planula larvae of Halocordyle disticha were examined for the presence of catecholamines using a multipronged approach. Transmission electron micrographs of planular sensory cells and ganglionic cells demonstrated dense-cored vesicles and electron-dense droplets in both cell types. These vesicles and droplets were similar in morphology to catecholamine-containing granules of vertebrates. Planulae processed with the SPG histofluorescence technique, specific only for catecholamines, exhibited blue-green fluorophores which were most prominent in the anterior ectoderm. Such fluorescence was associa
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32

Jaillard, S., V. Houfflin-Debarge, Y. Riou, et al. "Effects of catecholamines on the pulmonary circulation in the ovine fetus." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 281, no. 2 (2001): R607—R614. http://dx.doi.org/10.1152/ajpregu.2001.281.2.r607.

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High levels of circulating catecholamines are found in the fetus, and fetal stress and birth induce a marked surge in catecholamine secretion. Little is known about the role of catecholamines on the fetal pulmonary circulation. To determine the effects of catecholamines on the pulmonary vascular tone, we tested the hemodynamic response to norepinephrine and dopamine infusion in chronically prepared late-gestation fetal lambs. We found that norepinephrine infusion (0.5 μg · kg−1· min−1) increased pulmonary artery pressure (PAP) by 10 ± 1% ( P < 0.01), left pulmonary artery blood flow by 73 ±
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33

Lenz, T., E. Werle, G. Strobel та H. Weicker. "O-Methylated and sulfoconjugated catecholamines: differential activities at human platelet α2-adrenoceptors". Canadian Journal of Physiology and Pharmacology 69, № 7 (1991): 929–37. http://dx.doi.org/10.1139/y91-141.

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The physiological effects of the sulfoconjugates of epinephrine, norepinephrine, and the 3-O-methylated catecholamines, metanephrine, normetanephrine, and methoxytyramine were examined with regard to their α2-adrenoceptor binding properties and aggregation activity in human platelets. Sulfoconjugation of catecholamines resulted in the loss of both their competitive potency for [3H]yohimbine binding and their influence on platelet aggregation. O-Methyl substituted catecholamines showed attenuation of their α2-adrenoceptor binding affinities when compared with those of the corresponding non-ethe
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Quelhas-Santos, Janete, Benedita Sampaio-Maia, Fernando Remião, et al. "Assessment of Renalase Activity on Catecholamines Degradation." Open Hypertension Journal 7, no. 1 (2015): 14–18. http://dx.doi.org/10.2174/1876526201507010014.

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Renalase was recently described as a new flavoprotein that functions as FAD/NADH-dependent oxidase and, in contrast to other monoamine oxidases, is secreted into plasma and urine. Recombinant renalase was found to exert powerful and rapid hypotensive effects when administered intravenously on rats and this was suggested to be mediated by circulating catecholamines degradation. However there is no concrete evidence that directly supports the hypothesis that renalase metabolizes catecholamines. In this study we aimed to evaluate the catecholamines-degrading renalase activity by three different t
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GAVRILOVIC, LJUBICA, VESNA STOJILJKOVIC, JELENA KASAPOVIC, NATASA POPOVIC, SNEZANA B. PAJOVIC, and SLADJANA DRONJAK. "Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats." Anais da Academia Brasileira de Ciências 85, no. 3 (2013): 999–1012. http://dx.doi.org/10.1590/s0001-37652013005000041.

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ABSTRACT Chronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-ß-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma an
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36

Jiang, Qijiao, Neill A. Gingles, Marc A. Olivier, Lindsey A. Miles, and Robert J. Parmer. "The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles." Blood 117, no. 26 (2011): 7155–63. http://dx.doi.org/10.1182/blood-2010-05-287672.

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Recent studies suggest a crucial role for plasminogen activator inhibitor-1 (PAI-1) in mediating stress-induced hypercoagulability and thrombosis. However, the mechanisms by which PAI-1 is released by stress are not well-delineated. Here, we examined catecholaminergic neurosecretory cells for expression, trafficking, and release of PAI-1. PAI-1 was prominently expressed in PC12 pheochromocytoma cells and bovine adrenomedullary chromaffin cells as detected by Northern blotting, Western blotting, and specific PAI-1 ELISA. Sucrose gradient fractionation studies and immunoelectron microscopy demon
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Sakai, Kimiko, Mai Asano, Masahide Hamaguchi, Hidefumi Taniguchi, Osamu Ukimura, and Michiaki Fukui. "A Cortisol-Secreting Adrenal Adenoma Combined With a Micro-Pheochromocytoma: Case Report and Literature Review." Clinical Medicine Insights: Endocrinology and Diabetes 16 (January 2023): 117955142211485. http://dx.doi.org/10.1177/11795514221148556.

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Cushing’s syndrome and pheochromocytomas (PCCs) are associated with endocrine hypertension. Cortisol-producing adrenal adenomas are a major cause of Cushing’s syndrome. Simultaneous occurrence of cortisol-producing adrenal adenomas and PCCs is rare. Additionally, a PCC generally produces catecholamines in proportion to its size; therefore, micro-PCCs are rarely found in clinical practice. It is unknown whether micro-PCCs produce excess catecholamines during the pre-biochemical phase. Herein, we report the case of a 53-year-old woman who was referred to our hospital for further evaluation of le
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38

Strobel, Gɒnther, and HelmuT Weicker. "Catecholamine sulfates as internal standards in HPLC determinations of sulfoconjugated catecholamines in plasma and urine." Clinical Chemistry 37, no. 2 (1991): 196–99. http://dx.doi.org/10.1093/clinchem/37.2.196.

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Abstract A method is described to measure catecholamine sulfates from human plasma and urine by isocratic reversed-phase high-performance liquid chromatography with electrochemical detection. For this measurement we use catecholamine 3-sulfate isomers as internal standards and determine the sulfoconjugates only after eliminating the catecholamines. Catecholamines that have previously been used as internal standards are shown to cause a significant overestimation (P less than 0.05) of the catecholamine sulfates--by 10% to 25% and 20% to 42% in human plasma and urine, respectively. The detection
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Tang, Y., and R. G. Boutilier. "Correlation between catecholamine release and degree of acidotic stress in trout." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 255, no. 3 (1988): R395—R399. http://dx.doi.org/10.1152/ajpregu.1988.255.3.r395.

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Exhaustive exercise in freshwater (FW) and seawater (SW) rainbow trout resulted in a marked and acute increase of plasma catecholamines. Immediately after exercise, epinephrine and norepinephrine concentrations in FW trout were 69 and 15 times the resting level, respectively; in SW trout, they were 46 and 11 times the resting value, respectively. Over the 1st h of recovery, the magnitude of the catecholamine surge in FW animals was about twice that of their SW counterparts. Correlated with this was an extracellular pH disturbance in FW trout, which was approximately twice as severe as in SW tr
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Takiyyuddin, M. A., H. P. Neumann, J. H. Cervenka, et al. "Ultradian variations of chromogranin A in humans." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 261, no. 4 (1991): R939—R944. http://dx.doi.org/10.1152/ajpregu.1991.261.4.r939.

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Chromogranin A (CgA) is an acidic soluble protein exocytotically released from virtually all neuroendocrine secretory vesicles. Here we examined spontaneous variations in CgA and catecholamine concentrations in humans. In normal subjects, basal CgA showed no day-to-day, week-to-week, or diurnal variability. Plasma CgA had significant ultradian variation in normotensives and hypertensives, and in bilaterally adrenalectomized subjects. Gender, but not age or blood pressure, influenced CgA variations, males having fewer (P less than 0.05) peaks per 8 h. Plasma catecholamines had significant ultra
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Seibold, Jordan, and Ashley Ross. "Sub-second release of Neurotransmitters from CD4+ T lymphocytes." Journal of Immunology 212, no. 1_Supplement (2024): 0493_4408. http://dx.doi.org/10.4049/jimmunol.212.supp.0493.4408.

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Abstract The neuroimmune system is complex and is regulated by small chemical messengers released from resident immune and neuronal cells. Catecholamines like dopamine and norepinephrine are important chemical messengers responsible for initiating and propagating messages between neurons and immune cells; however, the mechanism and dynamics of this signaling are relatively unknown. The presence of the intracellular machinery to synthesize and interact with catecholamines in T lymphocytes has been known for over a decade; however, direct measurement of catecholamine secretion in real time from
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Seibold, Jordan M., and Ashley Ross. "Subsecond release of catecholamines from CD4+ T lymphocytes." Journal of Immunology 210, no. 1_Supplement (2023): 83.11. http://dx.doi.org/10.4049/jimmunol.210.supp.83.11.

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Abstract The neuroimmune system is complex and is regulated by small chemical messengers released from resident immune and neuronal cells. Catecholamines like dopamine and norepinephrine are important chemical messengers responsible for initiating and propagating messages between neurons and immune cells; however, the mechanism and dynamics of this signaling is relatively unknown. The presence of the intracellular machinery to synthesize and interact with catecholamines in T lymphocytes has been known for over a decade; however, direct measurement of catecholamine secretion in real time from i
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43

Boone, J. B., T. Sherraden, K. Pierzchala, R. Berger, and G. R. Van Loon. "Plasma Met-enkephalin and catecholamine responses to intense exercise in humans." Journal of Applied Physiology 73, no. 1 (1992): 388–92. http://dx.doi.org/10.1152/jappl.1992.73.1.388.

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Native and cryptic Met-enkephalin and catecholamines are coreleased in response to stress. However, it is not known whether Met-enkephalin and catecholamines exhibit concurrent temporal relationships in response to exercise. The purpose of this investigation was to examine the corelease of catecholamines and Met-enkephalin in endurance-trained (n = 6) and untrained (n = 6) male subjects during a 6-min bout of exercise: 4 min at 70% of maximal O2 uptake (VO2max) followed by 2 min at 120% VO2max. Peak catecholamine levels were found at 1 min of recovery. In trained subjects, native Met-enkephali
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Ikarugi, Hideo, Tomomi Taka, Shoko Nakajima, et al. "Norepinephrine, but not epinephrine, enhances platelet reactivity and coagulation after exercise in humans." Journal of Applied Physiology 86, no. 1 (1999): 133–38. http://dx.doi.org/10.1152/jappl.1999.86.1.133.

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The effects of exercise and catecholamines on platelet reactivity or coagulation and fibrinolysis appear to be inconsistent. This may be partly due to the methods employed in previous studies. In the present study, we investigated the effects of acute aerobic exercise and catecholamines on the thrombotic status by a novel in vitro method, shear-induced hemostatic plug formation (hemostatometry), using nonanticoagulated (native) blood. Aerobic exercise (60% maximal O2consumption) was performed by healthy male volunteers for 20 min, and the effect on platelet reactivity and coagulation was asses
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Fredj, Zina, and Mohamad Sawan. "Advanced Nanomaterials-Based Electrochemical Biosensors for Catecholamines Detection: Challenges and Trends." Biosensors 13, no. 2 (2023): 211. http://dx.doi.org/10.3390/bios13020211.

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Catecholamines, including dopamine, epinephrine, and norepinephrine, are considered one of the most crucial subgroups of neurotransmitters in the central nervous system (CNS), in which they act at the brain’s highest levels of mental function and play key roles in neurological disorders. Accordingly, the analysis of such catecholamines in biological samples has shown a great interest in clinical and pharmaceutical importance toward the early diagnosis of neurological diseases such as Epilepsy, Parkinson, and Alzheimer diseases. As promising routes for the real-time monitoring of catecholamine
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Montpetit, C. J., and S. F. Perry. "Neuronal control of catecholamine secretion from chromaffin cells in the rainbow trout (Oncorhynchus mykiss)." Journal of Experimental Biology 202, no. 15 (1999): 2059–69. http://dx.doi.org/10.1242/jeb.202.15.2059.

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The goal of the present investigation was to assess the relative involvement of nicotinic and muscarinic cholinergic receptors in the neuronal control of catecholamine secretion from the chromaffin tissue of rainbow trout (Oncorhynchus mykiss). This was accomplished by first developing and validating a nerve-stimulating technique able specifically to activate the nerve fibres innervating the chromaffin cells in order to elicit secretion of catecholamines. Using an in situ saline-perfused posterior cardinal vein preparation, it was demonstrated that whole-body field stimulation caused specific
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Kostyn, Kamil, Aleksandra Boba, Anna Kostyn, et al. "Expression of the Tyrosine Hydroxylase Gene from Rat Leads to Oxidative Stress in Potato Plants." Antioxidants 9, no. 8 (2020): 717. http://dx.doi.org/10.3390/antiox9080717.

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Catecholamines are biogenic aromatic amines common among both animals and plants. In animals, they are synthesized via tyrosine hydroxylation, while both hydroxylation or decarboxylation of tyrosine are possible in plants, depending on the species, though no tyrosine hydroxylase—a counterpart of the animal enzyme—has been identified yet. It is known that in potato plants, it is the decarboxylation of tyrosine that leads to catecholamine production. In this paper, we present the effects of the induction of an alternative route of catecholamine production by introducing the tyrosine hydroxylase
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48

Santos, Jenn Rachelle U., Alessandra Brofferio, Bruna Viana, and Karel Pacak. "Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease?" Hormone and Metabolic Research 51, no. 07 (2018): 458–69. http://dx.doi.org/10.1055/a-0669-9556.

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AbstractPheochromocytomas and paragangliomas (PHEOs) are rare neuroendocrine tumors. Clinical manifestations include different cardiovascular signs and symptoms, which are related to excessive secretion of catecholamines. Catecholamine-induced cardiomyopathy in PHEO (CICMPP) is a rare but dreaded complication of PHEO. Once patient is diagnosed with this condition, the prognosis is worse and a surgical risk is much higher than expected. This article focuses on how catecholamines affect the heart and the pathophysiologic mechanism of CICMPP. The cardiovascular responses to catecholamine depend m
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Aydin, Suna. "Renalase, Catecholamine and Nitric Oxide Changes Before and After Sodium Nitroprusside Administration to Patients who Develop Post-Coronary Artery By-Pass (CABG) Hypertension." Heart Surgery Forum 21, no. 5 (2018): E330—E336. http://dx.doi.org/10.1532/hsf.1998.

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Background: Hypertension develops at a rate of 33 to 70% after Coronary artery bypass grafting (CABG) operations. One of the most commonly used drugs to control hypertension is sodium nitroprusside (SNP). Additionally, renalase enzyme destroys catecholamines and mediates the regulation (reduction) of blood pressure. Thus, this clinical study aims to reveal how renalase, catecholamines and nitric oxide (NO) change and how certain hemodynamic parameters are affected in randomly and prospectively selected cases who are administered SNP for the treatment of blood pressure elevation within 6 to 8 h
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López García de Lomana, Adrián, Arnar Ingi Vilhjálmsson, Sarah McGarrity, et al. "Metabolic Response in Endothelial Cells to Catecholamine Stimulation Associated with Increased Vascular Permeability." International Journal of Molecular Sciences 23, no. 6 (2022): 3162. http://dx.doi.org/10.3390/ijms23063162.

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Disruption to endothelial cell homeostasis results in an extensive variety of human pathologies that are particularly relevant to major trauma. Circulating catecholamines, such as adrenaline and noradrenaline, activate endothelial adrenergic receptors triggering a potent response in endothelial function. The regulation of the endothelial cell metabolism is distinct and profoundly important to endothelium homeostasis. However, a precise catalogue of the metabolic alterations caused by sustained high catecholamine levels that results in endothelial dysfunction is still underexplored. Here, we un
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