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Journal articles on the topic 'Cathodal tDCS'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Lang, Nicolas, Michael A. Nitsche, Michele Dileone, et al. "Transcranial direct current stimulation effects on I-wave activity in humans." Journal of Neurophysiology 105, no. 6 (2011): 2802–10. http://dx.doi.org/10.1152/jn.00617.2010.

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Transcranial direct current stimulation (tDCS) of the human cerebral cortex modulates cortical excitability noninvasively in a polarity-specific manner: anodal tDCS leads to lasting facilitation and cathodal tDCS to inhibition of motor cortex excitability. To further elucidate the underlying physiological mechanisms, we recorded corticospinal volleys evoked by single-pulse transcranial magnetic stimulation of the primary motor cortex before and after a 5-min period of anodal or cathodal tDCS in eight conscious patients who had electrodes implanted in the cervical epidural space for the control

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Nejati, Vahid, Mohammad Ali Salehinejad, Michael A. Nitsche, Asal Najian, and Amir-Homayoun Javadi. "Transcranial Direct Current Stimulation Improves Executive Dysfunctions in ADHD: Implications for Inhibitory Control, Interference Control, Working Memory, and Cognitive Flexibility." Journal of Attention Disorders 24, no. 13 (2017): 1928–43. http://dx.doi.org/10.1177/1087054717730611.

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Objective: This study examined effects of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) on major executive functions (EFs), including response inhibition, executive control, working memory (WM), and cognitive flexibility/task switching in ADHD. Method: ADHD children received (a) left anodal/right cathodal DLPFC tDCS and (b) sham stimulation in Experiment 1 and (a) left anodal DLPFC/right cathodal OFC tDCS, (b) left cathodal DLPFC/right anodal OFC tDCS, and (c) sham stimulation in Experiment 2. The current intensity

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Dai, Wenjun, Yao Geng, Hao Liu, et al. "Preconditioning with Cathodal High-Definition Transcranial Direct Current Stimulation Sensitizes the Primary Motor Cortex to Subsequent Intermittent Theta Burst Stimulation." Neural Plasticity 2021 (October 21, 2021): 1–8. http://dx.doi.org/10.1155/2021/8966584.

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Noninvasive brain stimulation techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) can induce long-term potentiation-like facilitation, but whether the combination of TMS and tDCS has additive effects is unclear. To address this issue, in this randomized crossover study, we investigated the effect of preconditioning with cathodal high-definition (HD) tDCS on intermittent theta burst stimulation- (iTBS-) induced plasticity in the left motor cortex. A total of 24 healthy volunteers received preconditioning with cathodal HD-tDCS or sham int

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Spielmann, K., R. van der Vliet, W. M. E. van de Sandt-Koenderman, et al. "Cerebellar Cathodal Transcranial Direct Stimulation and Performance on a Verb Generation Task: A Replication Study." Neural Plasticity 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/1254615.

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The role of the cerebellum in cognitive processing is increasingly recognized but still poorly understood. A recent study in this field applied cerebellar Transcranial Direct Current Stimulation (c-tDCS) to the right cerebellum to investigate the role of prefrontal-cerebellar loops in language aspects of cognition. Results showed that the improvement in participants’ verbal response times on a verb generation task was facilitated immediately after cathodal c-tDCS, compared to anodal or sham c-tDCS. The primary aim of the present study is to replicate these findings and additionally to investig

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Wang, Jiarui, Jinhua Tian, Renning Hao, Lili Tian, and Qiang Liu. "Transcranial direct current stimulation over the right DLPFC selectively modulates subprocesses in working memory." PeerJ 6 (May 28, 2018): e4906. http://dx.doi.org/10.7717/peerj.4906.

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Background Working memory, as a complex system, consists of two independent components: manipulation and maintenance process, which are defined as executive control and storage process. Previous studies mainly focused on the overall effect of transcranial direct current stimulation (tDCS) on working memory. However, little has been known about the segregative effects of tDCS on the sub-processes within working memory. Method Transcranial direct current stimulation, as one of the non-invasive brain stimulation techniques, is being widely used to modulate the cortical activation of local brain a

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Kamada, Hiroshi, and Naoyuki Takeuchi. "Transcranial Direct Current Stimulation over the Temporoparietal Junction Modulates Posture Control in Unfamiliar Environments." Brain Sciences 13, no. 11 (2023): 1514. http://dx.doi.org/10.3390/brainsci13111514.

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The temporoparietal junction (TPJ), which integrates visual, somatosensory, and vestibular information to form body schema, is involved in human postural control. We evaluated whether or not the transcranial direct current stimulation (tDCS) of the TPJ can modulate postural control on an unstable surface with eyes closed, during which the updating of body schema is needed to maintain balance. Sixteen healthy subjects participated in this study. The order of the three types of tDCS (anodal, cathodal, and sham) over the right TPJ was counterbalanced across the participants. We evaluated dynamic

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Paquette, Caroline, Michael Sidel, Basia A. Radinska, Jean-Paul Soucy, and Alexander Thiel. "Bilateral Transcranial Direct Current Stimulation Modulates Activation-Induced Regional Blood Flow Changes during Voluntary Movement." Journal of Cerebral Blood Flow & Metabolism 31, no. 10 (2011): 2086–95. http://dx.doi.org/10.1038/jcbfm.2011.72.

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Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that induces changes in cortical excitability: anodal stimulation increases while cathodal stimulation reduces excitability. Imaging studies performed after unilateral stimulation have shown conflicting results regarding the effects of tDCS on surrogate markers of neuronal activity. The aim of this study was to directly measure these effects on activation-induced changes in regional cerebral blood flow (⊿rBF) using positron emission tomography (PET) during bilateral tDCS. Nine healthy subjects underwent

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Boggio, Paulo S., Alice Nunes, Sergio P. Rigonatti, Michael A. Nitsche, Alvaro Pascual-Leone, and Felipe Fregni. "Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients." Restorative Neurology and Neuroscience 25, no. 2 (2007): 123–29. https://doi.org/10.3233/rnn-2007-00375.

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Purpose: Recent evidence has suggested that a simple technique of noninvasive brain stimulation – transcranial direct current stimulation (tDCS) – is associated with a significant motor function improvement in stroke patients. Methods: We tested the motor performance improvement in stroke patients following 4 weekly sessions of sham, anodal- and cathodal tDCS (experiment 1) and the effects of 5 consecutive daily sessions of cathodal tDCS (experiment 2). A blinded rater evaluated motor function using the Jebsen-Taylor Hand Function Test. Results: There was a significant main effect of stimulati

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Valero-Cabré, Antoni, Clara Sanches, Juliette Godard, et al. "Language boosting by transcranial stimulation in progressive supranuclear palsy." Neurology 93, no. 6 (2019): e537-e547. http://dx.doi.org/10.1212/wnl.0000000000007893.

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ObjectiveTo explore whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can improve language capacities in patients with progressive supranuclear palsy (PSP).MethodsWe used a sham-controlled double-blind crossover design to assess the efficiency of tDCS over the DLPFC in a cohort of 12 patients with PSP. In 3 separate sessions, we evaluated the ability to boost the left DLPFC via left-anodal (excitatory) and right-cathodal (inhibitory) tDCS, while comparing them to sham tDCS. Tasks assessing lexical access (letter fluency task) and semantic ac

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de Venecia, Angelito Braulio F., and Shane M. Fresnoza. "Visual Cortex Transcranial Direct Current Stimulation for Proliferative Diabetic Retinopathy Patients: A Double-Blinded Randomized Exploratory Trial." Brain Sciences 11, no. 2 (2021): 270. http://dx.doi.org/10.3390/brainsci11020270.

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Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes. PDR-related retinal hemorrhages often lead to severe vision loss. The main goals of management are to prevent visual impairment progression and improve residual vision. We explored the potential of transcranial direct current stimulation (tDCS) to enhance residual vision. tDCS applied to the primary visual cortex (V1) may improve visual input processing from PDR patients’ retinas. Eleven PDR patients received cathodal tDCS stimulation of V1 (1 mA for 10 min), and another eleven patients received sham stimulation (1

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Liu, Hui-Hua, Xiao-Kuo He, Hsin-Yung Chen, et al. "Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats." Neural Plasticity 2019 (December 17, 2019): 1–9. http://dx.doi.org/10.1155/2019/4252943.

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Transcranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders. For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable condition for identifying mechanisms that can help to explore therapeutic strategies. Here, we developed a tDCS protocol for modulating motor excitability in anesthetized rats. To examine the responses of tDCS-elicited plasticity, the motor evoked potential (MEP) and MEP input-output (IO) curve elicit

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Jahshan, Carol, Jonathan K. Wynn, Brian J. Roach, Daniel H. Mathalon, and Michael F. Green. "Effects of Transcranial Direct Current Stimulation on Visual Neuroplasticity in Schizophrenia." Clinical EEG and Neuroscience 51, no. 6 (2020): 382–89. http://dx.doi.org/10.1177/1550059420925697.

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People with schizophrenia (SZ) exhibit visual processing abnormalities that affect their daily functioning and remediating these deficits might help to improve functioning. Transcranial direct current stimulation (tDCS) is a potential tool for perceptual enhancement for this purpose, though there are no reports of tDCS applied to visual cortex in SZ. In a within-subject, crossover design, we evaluated the effects of tDCS on visual processing in 27 SZ. All patients received anodal, cathodal, or sham stimulation over the central occipital region in 3 visits separated by 1 week. In each visit, a

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Monte-Silva, Katia, Min-Fang Kuo, David Liebetanz, Walter Paulus, and Michael A. Nitsche. "Shaping the Optimal Repetition Interval for Cathodal Transcranial Direct Current Stimulation (tDCS)." Journal of Neurophysiology 103, no. 4 (2010): 1735–40. http://dx.doi.org/10.1152/jn.00924.2009.

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Transcranial DC stimulation (tDCS) is a plasticity-inducing noninvasive brain stimulation tool with various potential therapeutic applications in neurological and psychiatric diseases. Currently, the duration of the aftereffects of stimulation is restricted. For future clinical applications, stimulation protocols are required that produce aftereffects lasting for days or weeks. Options to prolong the effects of tDCS are further prolongation or repetition of tDCS. Nothing is known thus far about optimal protocols in this behalf, although repetitive stimulation is already performed in clinical a

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Hansen, Niels, Mark Obermann, Franziska Poitz, et al. "Modulation of human trigeminal and extracranial nociceptive processing by transcranial direct current stimulation of the motor cortex." Cephalalgia 31, no. 6 (2011): 661–70. http://dx.doi.org/10.1177/0333102410390394.

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Objective: The study was conducted to investigate the after-effect of transcranial direct current stimulation (tDCS) applied over the human primary motor cortex (M1) on trigeminal and extracranial nociceptive processing. Basic procedures: Nineteen healthy volunteers were stimulated using cathodal, anodal (both 1 mA) or sham tDCS for 20 minutes. Pain processing was assessed by recording trigeminal and extracranial pain-related evoked potentials (PREPs) following electrical stimulation of the contralateral forehead and hand at baseline, 0, 20 and 50 minutes post-tDCS. Main findings: Cathodal tDC

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Li, Lucia, Robert Leech, Barry Seemungal, Paresh Malhotra, and David Sharp. "A SENSE OF DIRECTION: BRAIN STIMULATION IN LATERALISED BRAIN FUNCTION." Journal of Neurology, Neurosurgery & Psychiatry 86, no. 11 (2015): e4.109-e4. http://dx.doi.org/10.1136/jnnp-2015-312379.21.

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Many cognitive functions demonstrate varying degrees of hemispheric lateralisation. Lateralised pathology can lead to striking deficits, such as the dyscalculia produced by dominant parietal lesions.Transcranial direct current stimulation (tDCS) non-invasively delivers weak electrical currents to the brain, resulting in transient changes in neuronal excitability: anodal tDCS is thought to be facilitatory, whilst cathodal is inhibitory.We investigated the effect of bi-parietal tDCS on numeracy, spatial attention and, sustained attention. We hypothesised that tDCS has distinct effects because of

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Bolognini, Nadia, Luca Zigiotto, Maíra Izzadora Souza Carneiro, and Giuseppe Vallar. "“How Did I Make It?”: Uncertainty about Own Motor Performance after Inhibition of the Premotor Cortex." Journal of Cognitive Neuroscience 28, no. 7 (2016): 1052–61. http://dx.doi.org/10.1162/jocn_a_00950.

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Optimal motor performance requires the monitoring of sensorimotor input to ensure that the motor output matches current intentions. The brain is thought to be equipped with a “comparator” system, which monitors and detects the congruence between intended and actual movement; results of such a comparison can reach awareness. This study explored in healthy participants whether the cathodal transcranial direct current stimulation (tDCS) of the right premotor cortex (PM) and right posterior parietal cortex (PPC) can disrupt performance monitoring in a skilled motor task. Before and after tDCS, par

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Haghdoost, Faraidoon, Abdul Salam, Fatemeh Zahra Seyed-Kolbadi, Deepika Padala, Candice Delcourt, and Anthony Rodgers. "Transcranial Direct Current Stimulation in Episodic Migraine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Medical Sciences 13, no. 3 (2025): 84. https://doi.org/10.3390/medsci13030084.

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Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique for migraine prevention. This study evaluates the efficacy of tDCS compared to sham in preventing episodic migraine in adults. Methods: PubMed and Embase databases were searched until May 2025 to identify randomized controlled trials comparing tDCS with sham for the prevention of episodic migraine in adults. Risk of bias in the included trials was assessed using the Cochrane Risk of Bias Tool version 2. A random effect meta-analysis was conducted to evaluate the effects of cathodal and anodal

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Mannarelli, Daniela, Caterina Pauletti, Alessia Petritis, et al. "Effects of Cerebellar tDCS on Inhibitory Control: Evidence from a Go/NoGo Task." Cerebellum 19, no. 6 (2020): 788–98. http://dx.doi.org/10.1007/s12311-020-01165-z.

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Abstract Response inhibition as an executive function refers to the ability to suppress inappropriate but prepotent responses. Several brain regions have been implicated in the process underlying inhibitory control, including the cerebellum. The aim of the present study was to explore the role of the cerebellum in executive functioning, particularly in response inhibition. For this purpose, we transitorily inhibited cerebellar activity by means of cathodal tDCS and studied the effects of this inhibition on ERP components elicited during a Go/NoGo task in healthy subjects. Sixteen healthy subje

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Chu, Che-Sheng, Yen-Yue Lin, Cathy Chia-Yu Huang, et al. "Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive Compulsive Disorder: A Randomized, Single-Blind Clinical Trial." Medicina 61, no. 2 (2025): 169. https://doi.org/10.3390/medicina61020169.

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Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation for treatment-resistant obsessive compulsive disorder (OCD). We aim to compare the treatment outcomes of a newly developed dual-site cathodal tDCS method over the orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA) and two previously reported montages (cerebellum-OFC and pre-SMA) in patients with treatment-resistant OCD. Methods: Eighteen OCD patients were randomly assigned to receive twice-daily 2 mA/20 min sessions for 10 consecutive weekdays, with the active cathode placed on the

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Fusco, Augusto, Federica Assenza, Marco Iosa, et al. "The Ineffective Role of Cathodal tDCS in Enhancing the Functional Motor Outcomes in Early Phase of Stroke Rehabilitation: An Experimental Trial." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/547290.

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Transcranial direct current stimulation (tDCS) is a noninvasive technique that could improve the rehabilitation outcomes in stroke, eliciting neuroplastic mechanisms. At the same time conflicting results have been reported in subacute phase of stroke, when neuroplasticity is crucial. The aim of this double-blind, randomized, and sham-controlled study was to determine whether a treatment with cathodal tDCS before the rehabilitative training might augment the final outcomes (upper limb function, hand dexterity and manual force, locomotion, and activities of daily living) in respect of a traditio

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Jefferson, Samantha, Satish Mistry, Salil Singh, John Rothwell, and Shaheen Hamdy. "Characterizing the application of transcranial direct current stimulation in human pharyngeal motor cortex." American Journal of Physiology-Gastrointestinal and Liver Physiology 297, no. 6 (2009): G1035—G1040. http://dx.doi.org/10.1152/ajpgi.00294.2009.

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Transcranial direct current stimulation (tDCS) is a novel intervention that can modulate brain excitability in health and disease; however, little is known about its effects on bilaterally innervated systems such as pharyngeal motor cortex. Here, we assess the effects of differing doses of tDCS on the physiology of healthy human pharyngeal motor cortex as a prelude to designing a therapeutic intervention in dysphagic patients. Healthy subjects ( n = 17) underwent seven regimens of tDCS (anodal 10 min 1 mA, cathodal 10 min 1 mA, anodal 10 min 1.5 mA, cathodal 10 min 1.5 mA, anodal 20 min 1 mA,

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Pikhovych, Anton, Nina Paloma Stolberg, Lea Jessica Flitsch, et al. "Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain." Stem Cells International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/2715196.

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Transcranial direct current stimulation (tDCS) has been suggested as an adjuvant tool to promote recovery of function after stroke, but the mechanisms of its action to date remain poorly understood. Moreover, studies aimed at unraveling those mechanisms have essentially been limited to the rat, where tDCS activates resident microglia as well as endogenous neural stem cells. Here we studied the effects of tDCS on microglia activation and neurogenesis in the mouse brain. Male wild-type mice were subjected to multisession tDCS of either anodal or cathodal polarity; sham-stimulated mice served as

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Ghosh, Soumya, and Lakshmi Nagarajan. "Tolerability and Effectiveness of Cathodal Transcranial Direct Current Stimulation in Children with Refractory Epilepsy: A Case Series." Brain Sciences 13, no. 5 (2023): 760. http://dx.doi.org/10.3390/brainsci13050760.

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There are limited treatment options for drug-resistant epilepsy (DRE) in children. We performed a pilot study to investigate the tolerability and effectiveness of cathodal transcranial direct current stimulation (tDCS) in DRE. Twelve children with DRE of varied etiology underwent three to four daily sessions of cathodal tDCS. The seizure frequency at 2 weeks before and after tDCS was obtained from seizure diaries; clinic reviews at 3 and 6 months assessed any longer-term benefits or adverse effects. The spike wave index (SWI) was analyzed in the EEGs done immediately before and after tDCS on t

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Lopez-Alonso, Virginia, Gabriel López-Bermúdez, Jeffrey Cayaban Pagaduan, and Jose Andrés Sánchez-Molina. "Does tDCS Enhance Complex Motor Skill Acquisition? Evidence from a Golf-Putting Task." Sensors 25, no. 14 (2025): 4297. https://doi.org/10.3390/s25144297.

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Transcranial direct current stimulation (tDCS) modulates cortical excitability, thus inducing improvements in motor learning of simple tasks. In this study, we aimed to evaluate the effect of different tDCS conditions—anodal stimulation over the motor cortex (M1), anodal and cathodal stimulation over the prefrontal cortex (PFC), and sham—on the online and offline learning of a complex accuracy task (golf-putting) in novice golfers. Methods: A total of 40 young, healthy subjects (24 men, 16 women) without previous golf experience were randomly distributed in four groups receiving sham, anodal M

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Ghayebzadeh, Shahrouz, Shirin Zardoshtian, Ehsan Amiri, Louis-Solal Giboin, and Daniel Gomes da Silva Machado. "Anodal Transcranial Direct Current Stimulation over the Right Dorsolateral Prefrontal Cortex Boosts Decision Making and Functional Impulsivity in Female Sports Referees." Life 13, no. 5 (2023): 1131. http://dx.doi.org/10.3390/life13051131.

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We investigated the effect of anodal transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (rDLPFC) on the sensitive decision making of female team sports referees. Twenty-four female referees voluntarily participated in this randomized, double-blind, crossover, and sham-controlled study. In three different sessions, participants received either anodal (a-tDCS; anode (+) over F4, cathode (−) over the supraorbital region (SO)), cathodal (c-tDCS; −F4/+SO), or sham tDCS (sh-tDCS) in a randomized and counterbalanced order. a-tDCS and c-tDCS were applied with

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Cabibel, Vincent, Makii Muthalib, Wei-Peng Teo, and Stephane Perrey. "High-definition transcranial direct-current stimulation of the right M1 further facilitates left M1 excitability during crossed facilitation." Journal of Neurophysiology 119, no. 4 (2018): 1266–72. http://dx.doi.org/10.1152/jn.00861.2017.

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The crossed-facilitation (CF) effect refers to when motor-evoked potentials (MEPs) evoked in the relaxed muscles of one arm are facilitated by contraction of the opposite arm. The aim of this study was to determine whether high-definition transcranial direct-current stimulation (HD-tDCS) applied to the right primary motor cortex (M1) controlling the left contracting arm [50% maximum voluntary isometric contraction (MVIC)] would further facilitate CF toward the relaxed right arm. Seventeen healthy right-handed subjects participated in an anodal and cathodal or sham HD-tDCS session of the right

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Mujib, Muhammad Danish, Ahmad Zahid Rao, Muhammad Abul Hasan, et al. "Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks." Biomedicines 12, no. 6 (2024): 1269. http://dx.doi.org/10.3390/biomedicines12061269.

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Pain is a multifaceted, multisystem disorder that adversely affects neuro-psychological processes. This study compares the effectiveness of central stimulation (transcranial direct current stimulation—tDCS over F3/F4) and peripheral stimulation (transcutaneous electrical nerve stimulation—TENS over the median nerve) in pain inhibition during a cognitive task in healthy volunteers and to observe potential neuro-cognitive improvements. Eighty healthy participants underwent a comprehensive experimental protocol, including cognitive assessments, the Cold Pressor Test (CPT) for pain induction, and

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Mansour, Anthony G., Rechdi Ahdab, Georges Khazen, et al. "Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study." Journal of Clinical Medicine 9, no. 4 (2020): 1075. http://dx.doi.org/10.3390/jcm9041075.

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Background: Medication overuse headache (MOH) is a chronic pain syndrome that arises from the frequent use of acute antimigraine drugs. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with a possible therapeutic effect in this particular context. Methods: This was a randomized, sham-controlled, cross-over study. Eighteen patients with MOH (17 women, age range: 20–38 years) received three sets of three consecutive daily sessions of tDCS: anodal tDCS over the prefrontal cortex, cathodal tDCS over the occipital cortex ipsilateral to the dominant side o

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Bellaïche, Lisa, Manish Asthana, Ann-Christine Ehlis, Thomas Polak, and Martin J. Herrmann. "The Modulation of Error Processing in the Medial Frontal Cortex by Transcranial Direct Current Stimulation." Neuroscience Journal 2013 (April 17, 2013): 1–10. http://dx.doi.org/10.1155/2013/187692.

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Background. In order to prevent future errors, we constantly control our behavior for discrepancies between the expected (i.e., intended) and the real action outcome and continuously adjust our behavior accordingly. Neurophysiological correlates of this action-monitoring process can be studied with event-related potentials (error-related negativity (ERN) and error positivity (Pe)) originating from the medial prefrontal cortex (mPFC). Patients with neuropsychiatric diseases often show performance monitoring dysfunctions potentially caused by pathological changes of cortical excitability; theref

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Ganho-Ávila, Ana, Óscar F Gonçalves, Raquel Guiomar, et al. "Cathodal tDCS enhances extinction-based procedures." L'Encéphale 45 (June 2019): S66. http://dx.doi.org/10.1016/j.encep.2019.04.009.

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Emadi Andani, Mehran, Bernardo Villa-Sánchez, Federico Raneri, Silvia Dametto, Michele Tinazzi, and Mirta Fiorio. "Cathodal Cerebellar tDCS Combined with Visual Feedback Improves Balance Control." Cerebellum 19, no. 6 (2020): 812–23. http://dx.doi.org/10.1007/s12311-020-01172-0.

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Abstract Balance control is essential to maintain a stable body position and to prevent falls. The aim of this study was to determine whether balance control could be improved by using cerebellar transcranial direct current stimulation (tDCS) and visual feedback in a combined approach. A total of 90 healthy volunteers were randomly assigned to six groups defined by the delivery of tDCS (cathodal or anodal or sham) and the provision or not of visual feedback on balance during the acquisition phase. tDCS was delivered over the cerebellar hemisphere ipsilateral to the dominant leg for 20 min at 2

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Lazzaro, Giulia, Sara Bertoni, Deny Menghini, et al. "Beyond Reading Modulation: Temporo-Parietal tDCS Alters Visuo-Spatial Attention and Motion Perception in Dyslexia." Brain Sciences 11, no. 2 (2021): 263. http://dx.doi.org/10.3390/brainsci11020263.

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Dyslexia is a neurodevelopmental disorder with an atypical activation of posterior left-hemisphere brain reading networks (i.e., temporo-occipital and temporo-parietal regions) and multiple neuropsychological deficits. Transcranial direct current stimulation (tDCS) is a tool for manipulating neural activity and, in turn, neurocognitive processes. While studies have demonstrated the significant effects of tDCS on reading, neurocognitive changes beyond reading modulation have been poorly investigated. The present study aimed at examining whether tDCS on temporo-parietal regions affected not only

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Almeida, Camila Carolinne Silva de, Marcelo Moraes Valença, Emanuela Paz Rosas, et al. "Electrical parameters of transcranial direct current stimulation that effectively alter cerebral blood flow in experimental animals: a systematic review." Research, Society and Development 11, no. 8 (2022): e22811830794. http://dx.doi.org/10.33448/rsd-v11i8.30794.

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Objective: To identify the electrical parameters of transcranial direct current stimulation (tDCS) that effectively alter cerebral blood flow in rats. Methodology: Six eletronic databases were searched with no time or language restrictions to identify experimental studies with rats using tDCS with anodal and/or cathodal stimulation with or without a comparison group. Internal validity was assessed via the following criteria: housing, lighting, temperature, water/food, groups randomization and ethical aspects. The ‘Laboratory Systematic Review Center for Laboratory animal Experimentation’ (SYRC

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Biabani, Mana, Maryam Aminitehrani, Maryam Zoghi, Michael Farrell, Gary Egan, and Shapour Jaberzadeh. "The effects of transcranial direct current stimulation on short-interval intracortical inhibition and intracortical facilitation: a systematic review and meta-analysis." Reviews in the Neurosciences 29, no. 1 (2017): 99–114. http://dx.doi.org/10.1515/revneuro-2017-0023.

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Abstract Transcranial direct current stimulation (tDCS) is increasingly being used to affect the neurological conditions with deficient intracortical synaptic activities (i.e. Parkinson’s disease and epilepsy). In addition, it is suggested that the lasting effects of tDCS on corticospinal excitability (CSE) have intracortical origin. This systematic review and meta-analysis aimed to examine whether tDCS has any effect on intracortical circuits. Eleven electronic databases were searched for the studies investigating intracortical changes induced by anodal (a) and cathodal (c) tDCS, in healthy i

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Frase, Piosczyk, Zittel, et al. "Modulation of Total Sleep Time by Transcranial Direct Current Stimulation (tDCS)." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 41, April (2016): 1–10. https://doi.org/10.5281/zenodo.3877674.

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Arousal and sleep are fundamental physiological processes, and their modulation is of high clinical significance. This study tested the hypothesis that total sleep time in humans can be modulated by the non-invasive brain stimulation technique transcranial direct current stimulation (tDCS) targeting a 'top-down' cortico-thalamic pathway of sleep-wake regulation. Nineteen healthy participants underwent a within-subject, repeated-measures protocol across five nights in the sleep laboratory with polysomnographic monitoring (adaptation, baseline, three experimental nights). tDCS was delive

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Caleb A, Adeagbo, Gbiri Caleb AO, and Olawale Olajide A. "Efficacy of transcranial direct current stimulation and over-ground walking task on functional mobility and quality of life of stroke survivors." Journal of Novel Physiotherapy and Rehabilitation 4, no. 2 (2020): 049–56. http://dx.doi.org/10.29328/journal.jnpr.1001037.

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Introduction: High proportion of stroke survivors have impaired functional mobility and decrease in overall quality of life (QoL). Transcranial direct current stimulation (tDCS) (non-invasive brain stimulation) and over-ground walking task (OGWT) (functional task-oriented training) have been suggested to improve functional mobility and QoL of stroke survivors. Hence, this study determined the efficacy of tDCS (anodal and cathodal) with OGWT on functional mobility and QoL of stroke survivors. Materials and methods: Seventy eight (78) stroke survivors were randomised into three groups: anodal gr

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Verma, Rohit, Ragul Ganesh, Shubham Narnoli, et al. "Effectiveness and tolerability of adjunctive transcranial direct current stimulation (tDCS) in management of treatment-resistant depression: A retrospective chart review." Indian Journal of Psychiatry 66, no. 6 (2024): 538–44. http://dx.doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_243_24.

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Background: There is a limited number of studies from India investigating the role of transcranial direct current stimulation (tDCS) in treatment-resistant depression (TRD). This clinic-based study reports on the effectiveness of tDCS as an add-on treatment in individuals suffering from TRD. Materials and Methods: Twenty-six right-handed individuals suffering from major depressive disorder who failed to respond to adequate trials of at least two antidepressant drugs in the current episode received tDCS as an augmenting treatment. Twice daily sessions of conventional tDCS were given providing a

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Pingue, Valeria, Alberto Priori, Alberto Malovini, and Caterina Pistarini. "Dual Transcranial Direct Current Stimulation for Poststroke Dysphagia: A Randomized Controlled Trial." Neurorehabilitation and Neural Repair 32, no. 6-7 (2018): 635–44. http://dx.doi.org/10.1177/1545968318782743.

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Background. Poststroke dysphagia is associated with considerable morbidity and has high health care cost implications. Objective. To evaluate whether anodal transcranial direct current stimulation (tDCS) over the lesioned hemisphere and cathodal tDCS to the contralateral one during the early stage of rehabilitation can improve poststroke dysphagia. Methods. A total of 40 patients referred to our neurorehabilitation department were randomized to receive anodal tDCS over the damaged hemisphere plus cathodal stimulation over the contralateral one versus sham stimulation during swallowing maneuver

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Keerthy, B. N., Sai Sreevalli Sarma Sreepada, Shalini S. Naik, et al. "Effects of a single session of cathodal transcranial direct current stimulation primed intermittent theta-burst stimulation on heart rate variability and cortical excitability measures." Indian Journal of Physiology and Pharmacology 65 (December 8, 2021): 162–66. http://dx.doi.org/10.25259/ijpp_339_2020.

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Objectives: Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have been used as neuromodulators in neuropsychiatric conditions. This study is aimed to find the effects of a single session of priming cathodal tDCS with intermittent theta-burst stimulation (iTBS) over left dorsolateral prefrontal cortex on heart rate variability (HRV) and cortical excitability parameters before and after perturbation. Materials and Methods: The neuromodulatory techniques used in the study were Cathodal tDCS for 20 min followed by iTBS for 3 min on the left dorsolateral pr

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McCambridge, Alana B., James W. Stinear, and Winston D. Byblow. "A dissociation between propriospinal facilitation and inhibition after bilateral transcranial direct current stimulation." Journal of Neurophysiology 111, no. 11 (2014): 2187–95. http://dx.doi.org/10.1152/jn.00879.2013.

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Propriospinal premotoneurons (PN) are essential for accurate control of the upper limb. They receive bilateral input from premotor (PM) and primary motor (M1) cortices. In humans, excitability of PNs can be estimated from motor-evoked potentials (MEPs) by pairing a descending volley using transcranial magnetic stimulation (TMS) to summate with an ascending volley from peripheral nerve stimulation at the C3–C4 level of the spinal cord. Transcranial direct current stimulation (tDCS) alters excitability of cortical and subcortical areas. A recent study demonstrated that cathodal tDCS can suppress

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Fricke, K., A. A. Seeber, N. Thirugnanasambandam, W. Paulus, M. A. Nitsche, and J. C. Rothwell. "Time course of the induction of homeostatic plasticity generated by repeated transcranial direct current stimulation of the human motor cortex." Journal of Neurophysiology 105, no. 3 (2011): 1141–49. http://dx.doi.org/10.1152/jn.00608.2009.

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Several mechanisms have been proposed that control the amount of plasticity in neuronal circuits and guarantee dynamic stability of neuronal networks. Homeostatic plasticity suggests that the ease with which a synaptic connection is facilitated/suppressed depends on the previous amount of network activity. We describe how such homeostatic-like interactions depend on the time interval between two conditioning protocols and on the duration of the preconditioning protocol. We used transcranial direct current stimulation (tDCS) to produce short-lasting plasticity in the motor cortex of healthy hum

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Smirni, Daniela, Massimiliano Oliveri, Eliana Misuraca, et al. "Verbal Fluency in Mild Alzheimer’s Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex." Journal of Alzheimer's Disease 81, no. 3 (2021): 1273–83. http://dx.doi.org/10.3233/jad-210003.

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Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks. Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer’s disease (A

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Carter, Michael J., Dana Maslovat, and Anthony N. Carlsen. "Anodal transcranial direct current stimulation applied over the supplementary motor area delays spontaneous antiphase-to-in-phase transitions." Journal of Neurophysiology 113, no. 3 (2015): 780–85. http://dx.doi.org/10.1152/jn.00662.2014.

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Coordinated bimanual oscillatory movements often involve one of two intrinsically stable phasing relationships characterized as in-phase (symmetrical) or antiphase (asymmetrical). The in-phase mode is typically more stable than antiphase, and if movement frequency is increasing during antiphase movements, a spontaneous transition to the in-phase pattern occurs. There is converging neurophysiological evidence that the supplementary motor area (SMA) plays a critical role in the successful performance of these patterns, especially during antiphase movements. We investigated whether modulating the

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Ahdab, Rechdi, Anthony G. Mansour, Georges Khazen, et al. "Cathodal Transcranial Direct Current Stimulation of the Occipital cortex in Episodic Migraine: A Randomized Sham-Controlled Crossover Study." Journal of Clinical Medicine 9, no. 1 (2019): 60. http://dx.doi.org/10.3390/jcm9010060.

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Summary: Three consecutive daily sessions of cathodal transcranial direct current stimulation (tDCS) was sufficient to show a significant decrease in headache duration and intensity as well as tablets consumption, in patients suffering from episodic migraine. Background: Migraine prophylaxis is recommended in patients with frequent and/or intense headaches, but poor tolerability and lack of efficacy of preventive drugs are common in clinical practice. Hence, new prophylactic strategies are needed. Objective: The aim of this study was to evaluate the efficacy of tDCS in terms of migraine prophy

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Fresnoza, Shane, Kjell Büsche, Maximilian Kern, et al. "Partially dissociative role of the left inferior frontal gyrus and left dorsolateral prefrontal cortex in reasoning." PLOS ONE 19, no. 12 (2024): e0312919. https://doi.org/10.1371/journal.pone.0312919.

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Reasoning is the ability to formulate inferences or conclusions from available information. The two major types, deductive and inductive, are thought to rely on distinct cognitive mechanisms and recruit separate brain areas. Neuroimaging studies yield mixed results; some found the left inferior frontal gyrus (IFG) activations for deductive reasoning and the left dorsolateral prefrontal cortex (DLPFC) for inductive reasoning. This assumption was put to the test in the present study. In two double-blinded, sham-controlled experiments, high-definition transcranial direct current stimulation (HD-t

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Swanson, Clayton W., and Felix Proessl. "High-definition transcranial direct-current stimulation of the right M1 further facilitates left M1 excitability during crossed facilitation." Journal of Neurophysiology 120, no. 1 (2018): 4–6. http://dx.doi.org/10.1152/jn.00177.2018.

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Cabibel et al. (J Neurophysiol 119: 1266–1272, 2018) report non-polarity-specific effects of high-definition direct current stimulation (HD-tDCS) on crossed facilitation (CF), demonstrated by complex excitatory and inhibitory interhemispheric interactions coupled with HD-tDCS. Choosing a variety of stimulation and muscle contraction parameters and having all participants undergo anodal, cathodal, and sham stimulation may increase the current understanding of HD-tDCS on CF. Furthermore, complementary metrics like the ipsilateral silent period may provide more clarity regarding the polarity-spec

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Shimizu, Renee E., Allan D. Wu, Jasmine K. Samra, and Barbara J. Knowlton. "The impact of cerebellar transcranial direct current stimulation (tDCS) on learning fine-motor sequences." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1711 (2017): 20160050. http://dx.doi.org/10.1098/rstb.2016.0050.

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The cerebellum has been shown to be important for skill learning, including the learning of motor sequences. We investigated whether cerebellar transcranial direct current stimulation (tDCS) would enhance learning of fine motor sequences. Because the ability to generalize or transfer to novel task variations or circumstances is a crucial goal of real world training, we also examined the effect of tDCS on performance of novel sequences after training. In Study 1, participants received either anodal, cathodal or sham stimulation while simultaneously practising three eight-element key press seque

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Vimolratana, Oranich, Alexandra Lackmy-Vallee, Benchaporn Aneksan, Vimonwan Hiengkaew, and Wanalee Klomjai. "Non-linear dose response effect of cathodal transcranial direct current stimulation on muscle strength in young healthy adults: a randomized controlled study." BMC Sports Science, Medicine and Rehabilitation 15, no. 1 (2023). http://dx.doi.org/10.1186/s13102-023-00621-7.

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Abstract Background Transcranial direct current stimulation (tDCS) is a technique that modulates brain excitability in humans. Increasing the stimulation intensity or duration within certain limits could enhance tDCS efficacy with a polarity-dependent effect; anodal stimulation increases cortical excitability, whereas cathodal stimulation decreases excitability. However, recent studies have reported a non-linear effect of cathodal tDCS on neuronal excitability in humans, and there is no conclusive result regarding the effect of cathodal tDCS on muscle performance. Methods Our study aimed to in

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Chen, Joyce L., Ashley Schipani, Clarissa Pedrini Schuch, et al. "Does Cathodal vs. Sham Transcranial Direct Current Stimulation Over Contralesional Motor Cortex Enhance Upper Limb Motor Recovery Post-stroke? A Systematic Review and Meta-analysis." Frontiers in Neurology 12 (April 15, 2021). http://dx.doi.org/10.3389/fneur.2021.626021.

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Background: During recovery from stroke, the contralesional motor cortex (M1) may undergo maladaptive changes that contribute to impaired interhemispheric inhibition (IHI). Transcranial direct current stimulation (tDCS) with the cathode over contralesional M1 may inhibit this maladaptive plasticity, normalize IHI, and enhance motor recovery.Objective: The objective of this systematic review and meta-analysis was to evaluate available evidence to determine whether cathodal tDCS on contralesional M1 enhances motor re-learning or recovery post-stroke more than sham tDCS.Methods: We searched OVID

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Wong, Pei-Ling, Yea-Ru Yang, Shun-Chang Tang, Shi-Fong Huang, and Ray-Yau Wang. "Comparing different montages of transcranial direct current stimulation on dual-task walking and cortical activity in chronic stroke: double-blinded randomized controlled trial." BMC Neurology 22, no. 1 (2022). http://dx.doi.org/10.1186/s12883-022-02644-y.

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Abstract Background Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation to modulate cortical activity for improving motor function. However, the different tDCS applications for modulating cortical activity and dual task gait performance in chronic stroke have not yet been investigated. This study investigated the effects of different tDCS applications on dual task gait performance and contralesional M1 activation in chronic stroke. Methods Forty-eight participants were randomized to anodal, bilateral, cathodal, and sham tDCS groups. Each group received 20 min of t

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