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Dissertations / Theses on the topic 'Cationic antimicrobial peptides'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Termén, Stefan. "Expression of cathelicidin antimicrobial peptides in man and rat /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-138-5/.

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2

Shyam, Radhe. "Cationic amphipathic peptoid oligomers as antimicrobial peptide mimics." Thesis, Université Clermont Auvergne‎ (2017-2020), 2018. http://www.theses.fr/2018CLFAC048/document.

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Les organismes vivants produisent des peptides antimicrobiens (PAMs) pour se protéger contre les microbes. La résistance croissante aux antibiotiques nécessite le développement de nouvelles stratégies thérapeutiques et les PAMs sont des candidats prometteurs pour résoudre ce problème. Ils possèdent une activité à large spectre et leur principal mécanisme d'action par perméation de la membrane engendre peu de phénomènes de résistance. Néanmoins, leur faible biodisponibilité empêche leur utilisation. Certaines limitations peuvent être surmontées en développant des mîmes de PAMs qui conservent le

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3

Harris, Mark R. "Effects of cationic antimicrobial peptides on Candida and Saccharomyces species." Thesis, St Andrews, 2010. http://hdl.handle.net/10023/881.

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4

Findlay, Brandon. "Design and synthesis of cationic amphiphiles." American Society for Microbiology, 2010. http://hdl.handle.net/1993/21708.

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Cationic antimicrobial peptides (CAMPs) are produced by plants, animals and bacteria to protect their host against antagonistic microbes. The antitheses of selective antibiotics, these peptides are drawn by electrostatic and hydrophobic interactions to targets as diverse as the bacterial membrane, nucleic acids and serum proteins. This lack of specificity is their greatest strength, as mutations to single genes rarely lead to bacterial resistance. Resistance may be conferred by large scale alterations in cell envelope composition, which generally reduces bacterial fitness in the absence of

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5

Bagheri, Mojtaba [Verfasser]. "Cationic antimicrobial peptides : thermodynamic characterization of peptide-lipid interactions and biological efficacy of surface-tethered peptides / Mojtaba Bagheri." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/1025126971/34.

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6

Cheng, John Tien Jui. "Investigating the structure-function relationship of cationic antimicrobial peptides and lipopeptides." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29358.

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Antibiotics have been playing a major role in combating bacterial infections for centuries. Since the discovery of modern antibiotics, numerous derivatives have been designed and developed to treat different bacterial infections. Recently, antibiotic resistance has been continuously and increasingly reported. The lack of antibiotic alternatives makes these resistant bacteria become more difficult to eliminate. Antimicrobial peptides constitute a major part of the innate immune system of an organism. Their high activity and little resistance make them ideal candidates for novel antibiotic

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7

Tollin, Maria. "Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-270-5/.

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8

Miskimins, Mills Beth Ellen. "Modulatory activities of glycosaminoglycans and other polyanionic polysaccharides on cationic antimicrobial peptides." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/557.

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Cationic antimicrobial peptides (CAPs) are an important component of the innate immune system and are instrumental in the elimination of bacteria, viruses, protozoa, yeast, fungi and cancerous cells from the body. CAPs are comprised of less than 100 amino acids and have a net positive charge due to a multitude of basic residues in their primary sequences. CAPs exert their antimicrobial activity primarily through the formation of pores in microbial membranes, but also play important immunostimulatory roles in the body. Glycosaminoglycans (GAGs) are negatively charged, polydisperse linear polysa

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9

Bergman, Peter. "Antimicrobial peptides and pathogenic Neisseria : experimental studies in mouse, man and rat /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-428-7/.

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10

Lisanby, Mark W. "Examination of the capacity of cathelicidins to control Bacillus anthracis pathogenesis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/lisanby.pdf.

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11

Company, Casadevall Núria. "Strategies for the production of cationic α-helical antimicrobial peptides in plant biofactories". Doctoral thesis, Universitat de Girona, 2014. http://hdl.handle.net/10803/284093.

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Antimicrobial Peptides have strong interest as a novel class of antimicrobial agents in the phytosanitary field. This Thesis focuses on the development of strategies to produce of BP100 derivatives (BP100ders) in genetically modified (GM) rice plant biofactories. The production of certain BP100ders using a strong constitutive promoter was toxic to the host plant and, impairing its viability. That phytotoxicity to the host was directly linked to the haemolytic activity of BP100ders. Transgenic plants were obtained that produced these peptides with yields up to 0.5% total soluble protein and ret

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12

Linde, Charlotte M. A. "Defense peptides against Mycobacteria /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-480-5/.

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13

Bergsson, Gudmundur. "Antimicrobial polypeptides and lipids as a part of innate defense mechanism of fish and human fetus /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-546-1/.

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14

Mankoci, Steven Gerald. "The Investigation of Water-Soluble Polyurethanes that Mimic Antimicrobial Peptides." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524649965130039.

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15

Karlsson, Jenny. "Regulation and characterization of antimicrobial peptides in man and mice /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-286-6/.

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16

Ringstad, Lovisa. "Interaction Between Antimicrobial Peptides and Phospholipid Membranes Effects of Peptide Length and Composition /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101989.

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17

Chan, Mei-sheung, and 陳美嫦. "Study of structure-function relationships in cationic antimicrobial peptides derived from human and porcine lactoferricins." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43572017.

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18

Chan, Mei-sheung. "Study of structure-function relationships in cationic antimicrobial peptides derived from human and porcine lactoferricins." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43572017.

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19

Monroc, Sylvie. "Synthesis and evaluation of cyclic cationic peptides as antimicrobial agents for use in plant protection." Doctoral thesis, Universitat de Girona, 2008. http://hdl.handle.net/10803/8045.

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Aquesta tesi doctoral se centra en l'estudi de l'aplicació de pèptids antimicrobians en la lluita contra agents patògens de cultius de plantes d'interès econòmic.L'estratègia sintètica s'ha portat a terme utilitzant metodologies convencionals de síntesi de pèptids en fase sòlida com l'estratègia tridimensional ortogonal Fmoc/tBut/Allyl. Ha calgut fer la recerca de les condicions òptimes per a l'eliminació del grup Allyl i la ciclació. D'entre els pèptids cíclics de 4-10 aminoacids sintetitzats, el decapèptid c(Lys-Leu-Lys-Leu-Lys-Phe-Lys-Lys-Leu-Gln) ha resultat ésser el més efectiu i s'ha pre

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20

Edfeldt, Kristina. "Innate immunity in atherosclerosis : signaling pattern recognition receptors and an antimicrobial peptide /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-299-3/.

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21

Heilborn, Johan. "The human antimicrobial protein hCAP18/LL37 in wound healing and cell proliferation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-432-5/.

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22

Caiaffa, Karina Sampaio [UNESP]. "Efeito citotóxico e antimicrobiano de análogos de peptídeos catiônicos e sua influencia na expressão de marcadores fenotípicos e genotípicos de mineralização dentinária." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/135976.

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Made available in DSpace on 2016-03-07T19:20:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-07-17. Added 1 bitstream(s) on 2016-03-07T19:24:21Z : No. of bitstreams: 1 000857883_20170806.pdf: 769729 bytes, checksum: 1dcde090f604e4d1d41fd32296602f3d (MD5) Bitstreams deleted on 2017-08-07T14:09:12Z: 000857883_20170806.pdf,. Added 1 bitstream(s) on 2017-08-07T14:10:16Z : No. of bitstreams: 1 000857883.pdf: 2232120 bytes, checksum: 69fcec972871be7dbe70a720530b6d84 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Conselho Nacional de Desenvolvimento Científico

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23

Caiaffa, Karina Sampaio. "Efeito citotóxico e antimicrobiano de análogos de peptídeos catiônicos e sua influencia na expressão de marcadores fenotípicos e genotípicos de mineralização dentinária." Araçatuba, 2015. http://hdl.handle.net/11449/135976.

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Orientadora: Cristiane Duque<br>Banca: Rodrigo Alex Arthur<br>Banca: Rogério de Castilho Jacinto<br>Resumo: Os objetivos do estudo foram avaliar os efeitos citotóxico e antimicrobiano de análogos de peptídeos catiônicos e sua influência na expressão de marcadores fenotípicos e genotípicos de mineralização dentinária. Fibroblastos da linhagem L929 foram expostas a diluições seriadas dos peptídeos LL-37 e análogos hBD-3-1CV e KR-12-a5 e a viabilidade das células foi avaliada por ensaios de metil tiazol tetrazólio (MTT). Concentração inibitória mínima (CIM) e concentração letal mínima (CLM) para

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24

Bysell, Helena. "Interaction Between Microgels and Oppositely Charged Peptides." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109203.

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Lightly cross-linked polyelectrolyte microgels are materials with interesting properties for a range of applications. For instance, the volume of these particles can be drastically changed in response to pH, ionic strength, temperature, or the concentration of specific ions and metabolites. In addition, microgel particles can bind substantial amounts of oppositely charged substances, such as proteins and peptides, and release them upon changes in the external environment. Consequently, microgels have potential in catalysis, photonics, biomaterials, and not at least, as protective and stimuli-s

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25

Aida, Kelly Limi. "Efeito microbiológico e citotóxico de sistemas nanoestruturados bioadesivos contendo fragmentos de peptídeos /." Araçatuba, 2017. http://hdl.handle.net/11449/151018.

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Orientador: Robson Frederico Cunha<br>Coorientadora: Cristiane Duque<br>Coorientadora: Sandra Maria Herondina Ávila de Aguiar<br>Banca: Ana Cláudia Okamoto<br>Banca: Marcelle Danellon<br>Banca: Juliana Campos Junqueira<br>Banca: Cássia Cilene Dezan Garbelini<br>Resumo: O uso de agentes antimicrobianos naturais que reduzam a adesão e proliferação de S. mutans no biofilme poderia ser uma estratégia interessante para o controle da cárie dentária. No entanto, a estabilidade química e física de alguns desses agentes, como os peptídeos catiônicos antimicrobianos e fragmentos de peptídeos, pode ser c

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26

Li, Yubo. "Design and Synthesis of Ceragenins–Cationic Steroid Antimicrobial Compounds, Structural Improvement and Synthesis of Cyclopentenone Prostaglandins and Modification and Synthesis of Derivatives of Ribityllumazines: Potential Antigens for Activation of MAIT Cells." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8283.

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Antimicrobial peptides (AMPs) are ubiquitous and display broad-spectrum antimicrobial activity that can control bacterial colonization of surfaces. Ceragenins are small-molecule mimics of AMPs and have several advantages over AMPs, including cost of manufacture and stability. A ceragenin, CSA-120, modified with an acrylamide group was directly incorporated into fluoropolymer coatings as a means of inhibiting bacterial biofilm formation. The ceragenin-containing coatings displayed improved performance. By conjugating a copper chelating group to the ceragenin, chelation of 64Cu by the conjugate

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27

Carlsson, Göran. "Kostmann syndrome : a clinical and pathophysiological study /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-059-1/.

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28

Richards, Susan Michelle. "PhoPQ- and PmrAB-mediated Lipopolysaccharide Modification and Cationic Antimicrobial Peptide Resistance in Salmonella enterica Serovars Typhimurium and Typhi." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1290981691.

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29

Inui, Kishi Rosangela Naomi 1982. "Avaliação da atividade de peptídeos antimicrobianos sobre o crescimento de patógenos bacterianos de citros = Evaluation of antimicrobial activity of peptides on citrus bacterial pathogen growth." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314468.

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Orientador: Marcos Antonio Machado<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo<br>Made available in DSpace on 2018-08-26T04:12:54Z (GMT). No. of bitstreams: 1 InuiKishi_RosangelaNaomi_D.pdf: 6372359 bytes, checksum: 51a90b9672af7cb590a1b270d3bc5d18 (MD5) Previous issue date: 2014<br>Resumo: A cultura do citros tem sido afetada por diversos patógenos como Xylella fastidiosa (Xf), Xanthomonas citri subsp. citri (Xcc) e Candidatus Liberibacter asiaticus (CaLas). Para o controle desses são necessárias grandes quantidades de defe

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30

Caiaffa, Karina Sampaio. "Efeito isolado ou combinado de flavonoides e peptídeos catiônicos sobre biofilme endodôntico e sua influência na viabilidade celular, capacidade de migração e inibição de citocinas em fibroblastos /." Araçatuba, 2019. http://hdl.handle.net/11449/182019.

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Orientador: Cristiane Duque<br>Coorientador: Luciano Tavares Angelo Cintra<br>Banca: João Eduardo Gomes Filho<br>Banca: Thais Marchini de Oliveira Valarelli<br>Banca: Christine Men Martins<br>Resumo: Este trabalho foi dividido em dois capítulos que objetivou avaliar: 1) o efeito isolado ou combinado do flavonoide epigallocatechin-3-gallate (EGCG) em associação com o peptídeo LL-37 e seu análogo KR-12-a5 sobre a viabilidade celular de fibroblastos e sobre cultura planctônica, biofilme simples, dual-espécies e túbulos dentináios e 2) as interações sinérgicas do EGCG e proantocianidina do oxicoco

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31

Soldati, Kahena Rodrigues. "Peptídeos antimicrobianos e doença periodontal : influência do tabagismo na expressão de peptídeos antimicrobianos e possíveis efeitos de peptídeos sintéticos sobre biofilmes multi-espécies /." Araraquara, 2020. http://hdl.handle.net/11449/192943.

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Orientador: Daniela Leal Zandim-Barcelos<br>Resumo: Peptídeos antimicrobianos (PAMs) são importantes componentes da resposta do hospedeiro contra patógenos invasores. Além da ação antimicrobiana direta, podem também participar na modulação do sistema imune. No entanto, o papel dos PAMs na etiopatogênese da doença periodontal e os fatores de risco que podem influenciar sua expressão na cavidade bucal ainda não se encontram totalmente elucidados. Dessa forma, os objetivos do presente estudo foram: (1) avaliar a influência do tabagismo nos níveis de LL-37 e HNP 1-3 no fluido crevicular gengival (

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32

Katvars, Laura K. "Novel cationic peptides and polymers in the treatment of methicillin-resistant Staphylococcus aureus and multi-drug resistant Acinetobacter spp. skin infection isolates." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228984.

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Lopes, Filho Fernando César [UNESP]. "Simulações por dinâmica molecular fine-e coarse-grained das interações intermoleculares entre peptídeos antimicrobianos da família Mastoparano e membranas modelo." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/100887.

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Larsson, Sonny. "Mistletoes and Thionins : as Selection Models in Natural Products Drug Discovery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7705.

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35

Wan, Min. "Studies on leukotriene B₄ and alarmins in inflammatory responses." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-767-2/.

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Lopes, Filho Fernando César. "Simulações por dinâmica molecular fine-e coarse-grained das interações intermoleculares entre peptídeos antimicrobianos da família Mastoparano e membranas modelo /." São José do Rio Preto : [s.n.], 2012. http://hdl.handle.net/11449/100887.

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Orientador: José Roberto Ruggiero<br>Banca: Pedro Geraldo Pascutti<br>Banca: José Maria Pires<br>Banca: Alexandre Suman de Araújo<br>Banca: Sabrina Thais Broggio Costa<br>Resumo: Peptídeos antimicrobianos são moléculas biologicamente ativas que, geralmente, tem as membranas fosfolipídicas como alvo primário. Resultados de diferentes técnicas experimentais têm sugerido que esses peptídeos permeabilizam as membranas pela formação de poros. Parte dos peptídeos caracterizados apresentam especificidade de disrupção para membranas de bactérias, em detrimento das membranas dos hospedeiros. Essa carac

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Tran, An Xuong. "Periplasmic Modification of the 1-Phosphate Group of Lipid A in Gram-Negative Bacteria." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etd/2036.

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Modification of the lipid A domain of lipopolysaccharide (LPS) is important for the pathogenesis and virulence of various Gram-negative bacteria. The major lipid A species of Helicobacter pylori is significantly different from that of Escherichia coli. H. pylori lipid A contains fewer acyl chains and phosphate groups with only one Kdo sugar attached to the disaccharide backbone. However, H. pylori produces a minor lipid A species that resembles E. coli lipid A, suggesting that the major lipid A species results from the action of specific modifying enzymes. This work describes two enzymes, a l

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38

Domingues, Tatiana Moreira [UNIFESP]. "Síntese, estudos conformacionais e do mecanismo de ação da gomesina." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/10093.

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Chromek, Milan. "Urinary tract infection and renal scarring /." Stockholm, 2006. http://diss.kib.ki.se/2006/7140-844-4/.

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Wu, Manhong. "Characterization of bactenecin, a small antimicrobial cationic peptide." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0002/NQ39006.pdf.

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Silva, Jesseleine Cristine Monteiro da [UNESP]. "Síntese, caracterização e estudos da atividade biológica de peptídeos antimicrobianos derivados de Leucocinas TA33a." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151692.

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Bonamy, Clément. "Signalisation cellulaire et peptides antimicrobiens : rôle de la voie EGFR dans la régulation de la B-défensine 1 humaine." Thesis, Sorbonne Paris Cité, 2018. https://theses.md.univ-paris-diderot.fr/BONAMY_Clement_2_complete_20181005.pdf.

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La ß-défensine 1 humaine (HBD1) est un peptide antimicrobien codé par le gène DEFB1 et exprimé de manière constitutive par les cellules épithéliales aux interfaces entre le milieu extérieur et l’organisme. De par ses activités antimicrobiennes et facteurs suppresseurs de tumeur, HBD1 joue un rôle central dans le maintien de l’homéostasie et la protection de l’épithélium dans le côlon. Cependant, peu de travaux ont porté sur l’étude de sa régulation génétique. Contrairement aux autres défensines, l’expression d’HBD1 est altérée au cours de l’oncogenèse dans le côlon, comme observé dans d’autres

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Carvalho, Gabriel Costa de. "Análise do perfil fenotípico e funcional das células natural Killer e linfócitos TCD8+ no Líquen plano." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-09082016-164859/.

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INTRODUÇÃO: Líquen plano (LP) é uma doença mucocutânea de natureza inflamatória crônica de etiologia ainda desconhecida. Alterações na resposta imune inata, como aos padrões moleculares associados à patógenos (PAMPs) e padrões moleculares associados ao dano (DAMPs) podem levar à inflamação crônica e contribuir com a patogênese do LP. OBJETIVO: Avaliar o efeito da ativação via o DAMP S100A8 e o receptor Toll-like 4 (TLR-4) em células Natural killer (NK) e TCD8 citotóxicas e suas subpopulações de memória/efetoras em pacientes com LP. MÉTODOS: Foram selecionados 25 pacientes com LP (22 mulheres,

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Neto, Guilherme Tude Coelho. "Peptídeo antimicrobiano LL-37 e seus efeitos em stemness de diferentes células tumorais." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-06032017-104147/.

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Os peptídeos antimicrobianos desempenham papéis protetores críticos em uma gama de doenças humanas, incluindo o câncer. Vários estudos demonstraram funções - tais como proliferação, angiogênese, apoptose e imunomodulação - desses peptídeos em vias cancerígenas cruciais. Investigamos o papel do Peptídeo antimicrobiano LL-37 sobre stemness em câncer de mama (SKBR3) e células de melanoma (A375). Análise por PCR array da expressão diferencial de genes em SKBR3 e A375 com knockdown por siRNA para o mRNA de LL-37 revelou uma regulação negativa de genes relacionados com stemness, incluindo transcript

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McBride, Kent Alexander. "An in vitro assessment of an engineered cationic antimicrobial peptide (eCAP) against planktonic strains of E. faecalis." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5241.

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Thesis (M.S.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains viii, 33 p. : col. ill. Vita. Includes abstract. Includes bibliographical references (p. 26-31).

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Le, Guern Florent. "Inhibition de souches bactériennes par de nouveaux composés photosensibles conjugués à la Polymyxine B." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0075/document.

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L’émergence de nouvelles souches bactériennes résistantes a signé la fin de l’« âge d’or » des antibiotiques. L’organisation mondiale de la santé a reconnu l’imminence des problèmes associés à ces nouvelles bactéries, qui engendrent de nouveau une mortalité en augmentation. Afin de palier à ce problème, de nouvelles alternatives aux antibiotiques sont envisagées par les chercheurs à travers le monde. La thérapie photodynamique antimicrobienne est l’une de ces alternatives. Elle a su se démarquer grâce à son incapacité à induire la résistance bactérienne. Alors que les résultats furent initiale

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Barkhuizen, Helmien. "Mode of action studies of defensin peptides from native South African Brassicaceae species." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80365.

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Thesis (MSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Plant defensin peptides have become promising and attractive candidates to be used as antifungal agents in agricultural biotechnology. These peptides have a broad spectrum antifungal activity and play a vital role in the innate immune system of plants. Plant diseases caused by fungi are a major contributor to the decrease in the quality and safety of agricultural products. Due to the dangerous effects and negative environmental impact of pesticides, an effective, safe, natural and durable method to control crop pathogens ha

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Uzarski, Joshua Robert. "Reflection Absorption Infrared Spectroscopic Studies of Surface Chemistry Relevant to Chemical and Biological Warfare Agent Defense." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/26107.

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Reflection absorption infrared spectroscopy was used as the primary analysis technique to study the interfacial chemistry of surfaces relevant to chemical and biological warfare agent defense. Many strategies utilized by the military to detect and decompose chemical and biological warfare agents involve their interaction with surfaces. However, much of the chemistry that occurs at the interface between the agents and surfaces of interest remains unknown. The surface chemistry plays an important role in efficacy of both detection and decontamination technology, and by obtaining a deeper underst

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Ramos, Reinaldo Rodrigues. "Recombinant expression and activity of cationic antimicrobial peptides." Doctoral thesis, 2011. http://hdl.handle.net/1822/19652.

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Tese de doutoramento em Engenharia Química e Biológica<br>In the past 60 years, antibiotics have been critical in the fight against infectious disease caused by microorganisms. The increasing bacterial resistance to antibiotics is a serious public health problem. Much research has been dedicated to the development of new classes of antibiotics to overcome this situation. Antimicrobial peptides (AMPs) are generally defined as peptides of less than 50 amino acid residues, bearing positive charge due to multiple lysine and arginine residues and with 50% or more of hydrophobic residues. AMPs

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Yin, Lois Menglu. "Interactions of Cationic Antimicrobial Peptides with Bacterial Membranes and Biofilms." Thesis, 2012. http://hdl.handle.net/1807/33594.

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Cationic antimicrobial peptides (CAPs) offer a viable alternative to conventional antibiotics as they physically disrupt the bacterial membranes, leading to cell lysis and death. However, colonized bacteria often form “biofilms” – characterized by the overproduction of exopolysaccharides - that restrict the penetration of antibiotics; successful antimicrobial agents must evade this exopolysaccharide ‘matrix’ to reach the bacterial membrane. Since the Pseudomonas aeruginosa biofilm alginate traps CAPs by forming peptide-alginate complexes, the aim of this thesis is to better understand the mec

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