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Journal articles on the topic 'Cationic Vector'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

TAN, AMELIA LI MIN, ALISA XUE LING LIM, YITING ZHU, YI YAN YANG, and MAJAD KHAN. "CATIONIC BOLAAMPHIPHILES FOR GENE DELIVERY." COSMOS 10, no. 01 (2014): 25–38. http://dx.doi.org/10.1142/s0219607714400059.

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Advances in medical research have shed light on the genetic cause of many human diseases. Gene therapy is a promising approach which can be used to deliver therapeutic genes to treat genetic diseases at its most fundamental level. In general, nonviral vectors are preferred due to reduced risk of immune response, but they are also commonly associated with low transfection efficiency and high cytotoxicity. In contrast to viral vectors, nonviral vectors do not have a natural mechanism to overcome extra- and intracellular barriers when delivering the therapeutic gene into cell. Hence, its design h

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2

Bengali, Zain, and Lonnie D. Shea. "Gene Delivery by Immobilization to Cell-Adhesive Substrates." MRS Bulletin 30, no. 9 (2005): 659–62. http://dx.doi.org/10.1557/mrs2005.193.

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AbstractBiomaterials can potentially enhance the delivery of viral and nonviral vectors for both basic science and clinical applications.Vectors typically consist of nucleic acids (DNA, RNA) packaged with proteins, lipids, or cationic polymers, which facilitate cellular internalization and trafficking. These vectors can associate with biomaterials that support cell adhesion, a process we term substrate-mediated delivery. Substrate immobilization localizes the DNA and the delivery vector to the cellular microenvironment.The interaction between the vector and substrate must be appropriately bala

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Nakayama, Yasuhide, Takeshi Masuda, Makoto Nagaishi, Michiko Hayashi, Moto Ohira, and Mariko Harada-Shiba. "High Performance Gene Delivery Polymeric Vector: Nano-Structured Cationic Star Polymers (Star Vectors)." Current Drug Delivery 2, no. 1 (2005): 53–57. http://dx.doi.org/10.2174/1567201052772825.

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4

Porter, Colin D., Katalin V. Lukacs, Gary Box, Yasuhiro Takeuchi, and Mary K. L. Collins. "Cationic Liposomes Enhance the Rate of Transduction by a Recombinant Retroviral Vector In Vitro and In Vivo." Journal of Virology 72, no. 6 (1998): 4832–40. http://dx.doi.org/10.1128/jvi.72.6.4832-4840.1998.

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ABSTRACT Cationic liposomes enhanced the rate of transduction of target cells with retroviral vectors. The greatest effect was seen with the formulation DC-Chol/DOPE, which gave a 20-fold increase in initial transduction rate. This allowed an efficiency of transduction after brief exposure of target cells to virus plus liposome that could be achieved only after extensive exposure to virus alone. Enhancement with DC-Chol/DOPE was optimal when stable virion-liposome complexes were preformed. The transduction rate for complexed virus, as for virus used alone or with the polycation Polybrene, show

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Guo, Man, Yingcai Meng, Xiaoqun Qin та Wenhu Zhou. "Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety". Crystals 11, № 4 (2021): 347. http://dx.doi.org/10.3390/cryst11040347.

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Gene therapy has attracted particular attention for the treatment of various genetic diseases, and the development of gene delivery vectors is of utmost importance for in vivo applications of gene drugs. Various cationic polymers with high nucleic acid loading and intracellular transfection efficiency have been reported, however, their biological applications are limited by potential toxicity. Surface modification is a robust solution to detoxify the cationic vectors, but this can inevitably weaken the transfection efficiency. To address this dilemma, we reported the ability of a dopamine (DA)

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Marquet, Franck, Viorica Patrulea та Gerrit Borchard. "Comparison of triblock copolymeric micelles based on α- and ε-poly(L-lysine): a Cornelian choice". Polymer Journal 54, № 2 (2021): 199–209. http://dx.doi.org/10.1038/s41428-021-00552-5.

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AbstractDue to the lack of safe carriers for the delivery of small interfering RNA (siRNA), clinical applications of nucleotide-based therapeutics have been limited. In this study, biodegradable amphiphilic triblock copolymers with tailored molecular weights for each block composed of methoxy poly(ethylene glycol) (2000 g/mol), poly(L-lysine) (1300 g/mol) and poly(D,L-lactic acid) (1800 g/mol) (mPEG45-α-PLL10-PLA25) were synthesized and fully characterized. The peptide synthesis was carried out on a solid phase to limit the presence of cationic charges. The arrangement and availability of cati

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El-Mahdy, Ahmed F. M., Takayuki Shibata, Tsutomu Kabashima, Qinchang Zhu, and Masaaki Kai. "Delivery of siRNA using siRNA/cationic vector complexes encapsulated in dendrimer-like polymeric DNAs." RSC Advances 5, no. 41 (2015): 32775–85. http://dx.doi.org/10.1039/c5ra01032b.

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8

Berchel, Mathieu, Tony Le Gall, Olivier Lozach, Jean-Pierre Haelters, Tristan Montier, and Paul-Alain Jaffrès. "Lipophosphoramidate-based bipolar amphiphiles: their syntheses and transfection properties." Organic & Biomolecular Chemistry 14, no. 10 (2016): 2846–53. http://dx.doi.org/10.1039/c5ob02512e.

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9

Budker, Vladimir, Vladimir Gurevich, James E. Hagstrom, Fedor Bortzov, and Jon A. Wolff. "pH-sensitive, cationic liposomes: A new synthetic virus-like vector." Nature Biotechnology 14, no. 6 (1996): 760–64. http://dx.doi.org/10.1038/nbt0696-760.

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10

Ito, Akira, Tetsuya Takahashi, Yujiro Kameyama, Yoshinori Kawabe, and Masamichi Kamihira. "Magnetic Concentration of a Retroviral Vector Using Magnetite Cationic Liposomes." Tissue Engineering Part C: Methods 15, no. 1 (2009): 57–64. http://dx.doi.org/10.1089/ten.tec.2008.0275.

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11

Natsume, Atsushi, Masaaki Mizuno, Yasushi Ryuke, and Jun Yoshida. "Cationic Liposome Conjugation to Recombinant Adenoviral Vector Reduces Viral Antigenicity." Japanese Journal of Cancer Research 91, no. 4 (2000): 363–67. http://dx.doi.org/10.1111/j.1349-7006.2000.tb00953.x.

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12

Cui, Pengfei, Jianhe Ma, Huihui Zhang, et al. "Small Molecule Modifications Significantly Increase the Transfection Efficiency of Low-Molecular Polymer." Journal of Biomedical Nanotechnology 18, no. 2 (2022): 435–45. http://dx.doi.org/10.1166/jbn.2022.3252.

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Gene vectors with high biocompatibility and transfection efficiency are critical for successful gene therapy. PEI 25K (Polyethyleneimine 25K) is a common polymeric gene vector that has been employed as a positive control material in gene transfection studies due to its good performance in endosome escape. PEI 25K’s indegradability and abundance of positive charges, on the other hand, cause toxicity in cells, limiting its use. In this study, we developed the PEI-ER non-viral vector by adding an endoplasmic reticulum (ER) targeting ligand to low molecular weight PEI 1.8K. These small molecule mo

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Vemana, Hari Priya, Aishwarya Saraswat, Shraddha Bhutkar, Ketan Patel, and Vikas V. Dukhande. "A novel gene therapy for neurodegenerative Lafora disease via EPM2A-loaded DLinDMA lipoplexes." Nanomedicine 16, no. 13 (2021): 1081–95. http://dx.doi.org/10.2217/nnm-2020-0477.

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Aim: To develop novel cationic liposomes as a nonviral gene delivery vector for the treatment of rare diseases, such as Lafora disease – a neurodegenerative epilepsy. Materials & methods: DLinDMA and DOTAP liposomes were formulated and characterized for the delivery of gene encoding laforin and expression of functional protein in HEK293 and neuroblastoma cells. Results: Liposomes with cationic lipids DLinDMA and DOTAP showed good physicochemical characteristics. Nanosized DLinDMA liposomes demonstrated desired transfection efficiency, negligible hemolysis and minimal cytotoxicity. Western

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Matai, Ishita, and P. Gopinath. "Hydrophobic myristic acid modified PAMAM dendrimers augment the delivery of tamoxifen to breast cancer cells." RSC Advances 6, no. 30 (2016): 24808–19. http://dx.doi.org/10.1039/c6ra02391f.

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In the present study, cationic generation 5 polyamido amine (G5 PAMAM) dendrimers were hydrophobically modified by grafting the surface with lipid-like myristic acid (My) tails to augment their potential as a drug delivery vector in vitro.

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15

Kurosaki, Tomoaki, Takashi Kitahara, Mugen Teshima, et al. "Exploitation of De Novo Helper-Lipids for Effective Gene Delivery." Journal of Pharmacy & Pharmaceutical Sciences 11, no. 4 (2009): 56. http://dx.doi.org/10.18433/j31s3b.

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Purpose: In gene delivery, a fusogenic lipid such as dioleyl phosphatidylethanolamine (DOPE) which is a component of cationic liposomal vector is important factor for effective transfection efficiency. We investigated the effect of penetration enhancers as alternative helper-lipids to DOPE. Methods: Transdermal penetraion enhancers such as N-lauroylsarcosine (LS), (R)-(+)-limonene (LM), vitamin E (VE), and phosphatidyl choline from eggs (EggPC) were used in this experiments as helper-lipids with N-[1-(2, 3-dioleyloxy) propyl]-N, N, N-trimethlylammonium chloride (DOTMA) and cholesterol (CHOL).

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Ilies, Marc, William Seitz, and Alexandru Balaban. "Cationic Lipids in Gene Delivery: Principles, Vector Design and Therapeutical Applications." Current Pharmaceutical Design 8, no. 27 (2002): 2441–73. http://dx.doi.org/10.2174/1381612023392748.

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17

Roux, D., P. Chenevier, T. Pott, L. Navailles, O. Regev, and O. Monval. "Conception and Realization of a Non-Cationic Non-Viral DNA Vector." Current Medicinal Chemistry 11, no. 2 (2004): 169–77. http://dx.doi.org/10.2174/0929867043456133.

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18

Yang, Bin, Yun-xia Sun, Wen-jie Yi, et al. "A linear-dendritic cationic vector for efficient DNA grasp and delivery." Acta Biomaterialia 8, no. 6 (2012): 2121–32. http://dx.doi.org/10.1016/j.actbio.2012.02.013.

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19

Matsumoto, Megumi, Reiko Kishikawa, Tomoaki Kurosaki, et al. "Hybrid vector including polyethylenimine and cationic lipid, DOTMA, for gene delivery." International Journal of Pharmaceutics 363, no. 1-2 (2008): 58–65. http://dx.doi.org/10.1016/j.ijpharm.2008.07.010.

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20

Zhang, Fanghua, Chao Zhang, Shuangqing Fu, et al. "Amphiphilic Cationic Peptide-Coated PHA Nanosphere as an Efficient Vector for Multiple-Drug Delivery." Nanomaterials 12, no. 17 (2022): 3024. http://dx.doi.org/10.3390/nano12173024.

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Amphiphilic core–shell (ACS) nanoparticles are gaining increasing research interest for multi-drug delivery in cancer therapy. In this work, a new cationic peptide-coated PHA nanosphere was prepared by self-assembly of a hydrophobic core of biodegradable poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and a hydrophilic shell of fusion proteins of PHA granule-associated protein (PhaP) and cationic peptide RALA through a strong hydrophobic effect. The hydrophobic drug curcumin (Cur) was encapsulated in PHBHHx nanoparticles. The chemotherapy drug 5-fluorouracil (5-FU) was administered in

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21

Sanchez-Martos, Miguel, Gema Martinez-Navarrete, Adela Bernabeu-Zornoza, Lawrence Humphreys, and Eduardo Fernandez. "Evaluation and Optimization of Poly-d-Lysine as a Non-Natural Cationic Polypeptide for Gene Transfer in Neuroblastoma Cells." Nanomaterials 11, no. 7 (2021): 1756. http://dx.doi.org/10.3390/nano11071756.

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Cationic polypeptides and cationic polymers have cell-penetrating capacities and have been used in gene transfer studies. In this study, we investigate the capability of a polymer of d-lysine (PDL), a chiral form of α–Poly-lysine, as a possible nonviral vector for releasing genetic materials to neuroblastoma cells and evaluate its stability against proteases. We tested and compared its transfection effectiveness in vitro as a vehicle for the EGFP plasmid DNA (pDNA) reporter in the SH-SY5Y human neuroblastoma, HeLa, and 3T3 cell lines. Using fluorescent microscopy and flow cytometry, we demonst

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22

Newland, B., A. Aied, A. V. Pinoncely, et al. "Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain." Nanoscale 6, no. 13 (2014): 7526–33. http://dx.doi.org/10.1039/c3nr06737h.

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A cationic knot structured transfection vector showed a more favorable transfection profile for a neural cell type compared to other polyplexes whilst maintaining cell viability at over 80% after four days of culture and could mediate luciferase overexpression in the adult brain.

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23

Hoekstra, D., J. Rejman, L. Wasungu, F. Shi, and I. Zuhorn. "Gene delivery by cationic lipids: in and out of an endosome." Biochemical Society Transactions 35, no. 1 (2007): 68–71. http://dx.doi.org/10.1042/bst0350068.

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Cationic lipids are exploited as vectors (‘lipoplexes’) for delivering nucleic acids, including genes, into cells for both therapeutic and cell biological purposes. However, to meet therapeutic requirements, their efficacy needs major improvement, and better defining the mechanism of entry in relation to eventual transfection efficiency could be part of such a strategy. Endocytosis is the major pathway of entry, but the relative contribution of distinct endocytic pathways, including clathrin- and caveolae-mediated endocytosis and/or macropinocytosis is as yet poorly defined. Escape of DNA/RNA

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24

Butt, Muhammad Hammad, Muhammad Zaman, Abrar Ahmad, et al. "Appraisal for the Potential of Viral and Nonviral Vectors in Gene Therapy: A Review." Genes 13, no. 8 (2022): 1370. http://dx.doi.org/10.3390/genes13081370.

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Over the past few decades, gene therapy has gained immense importance in medical research as a promising treatment strategy for diseases such as cancer, AIDS, Alzheimer’s disease, and many genetic disorders. When a gene needs to be delivered to a target cell inside the human body, it has to pass a large number of barriers through the extracellular and intracellular environment. This is why the delivery of naked genes and nucleic acids is highly unfavorable, and gene delivery requires suitable vectors that can carry the gene cargo to the target site and protect it from biological degradation. T

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Tan, Zhi Lei, Bei Xing, Shi Ru Jia та Fang Lian Yao. "Preparation of ε-Polylysine Modified Silica Nanoparticles". Advanced Materials Research 712-715 (червень 2013): 511–14. http://dx.doi.org/10.4028/www.scientific.net/amr.712-715.511.

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Gene vector system is the key to realize gene transduction and therapy. A proper gene vector can introduce the target gene into cells securely, efficiently, controllably and easily, and achieve purposes of gene transfection and disease treatment after its expression. ε-polylysine (ε-PL),which is rich in cationic and has high penetrability through biological membrane,can be applied in DNA carrier. In this study, we presented a novel approach for preparing ε-polylysine modified silica nanoparticles and combinating them with plasmid DNA.

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Vighi, Eleonora, and Eliana Leo. "Studying thein vitrobehavior of cationic solid lipid nanoparticles as a nonviral vector." Nanomedicine 7, no. 1 (2012): 9–12. http://dx.doi.org/10.2217/nnm.11.168.

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27

Vitor, Micaela T., Patricia C. Bergami Santos, Jose A. M. Barbuto, and Lucimara G. de la Torre. "Cationic Liposomes as Non-viral Vector for RNA Delivery in Cancer Immunotherapy." Recent Patents on Drug Delivery & Formulation 7, no. 2 (2013): 99–110. http://dx.doi.org/10.2174/18722113113079990010.

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28

He, Zhijian, Lei Miao, Rainer Jordan, Devika S-Manickam, Robert Luxenhofer, and Alexander V. Kabanov. "A Low Protein Binding Cationic Poly(2-oxazoline) as Non-Viral Vector." Macromolecular Bioscience 15, no. 7 (2015): 1004–20. http://dx.doi.org/10.1002/mabi.201500021.

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Ochoa-Sánchez, C. I., K. Ochoa Lara, J. M. Martínez-Soto, et al. "Physicochemical Characterization and Viability Assays of a Promising Formulation of Liposomes (DODAB-DOPC) in Complexation with ctDNA." Journal of Nanomaterials 2022 (June 25, 2022): 1–10. http://dx.doi.org/10.1155/2022/3085103.

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The search of new genetic vectors that improve the efficacy of gene delivery into diseased cells has led to the creation of several vector formulations that promote effectiveness in applications. However, DNA affinity to vectors as well as vector/DNA complex stability remains a problem to be solved. Here, we study lipoplexes made of DODAB-DOPC cationic liposomes (CL) and calf thymus DNA (ctDNA) as a preliminary cargo gene model of a novel vector formulation to improve DNA delivery efficacy and affinity. Physicochemical characterization was carried out by Z -potential ( ζ ), light scattering, u

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Chen, Si, Jiguang Li, Xiaoyu Ma, Fan Liu, and Guoping Yan. "Cationic Peptide-Modified Gold Nanostars as Efficient Delivery Platform for RNA Interference Antitumor Therapy." Polymers 13, no. 21 (2021): 3764. http://dx.doi.org/10.3390/polym13213764.

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siRNA interference therapy can silence tumor cell target genes and specifically regulate tumor cell behavior and function, which is an effective antitumor therapy. However, in somatic circulation, naked siRNAs are not only susceptible to degrade, but it is also difficult to realize the tumor cells’ internalization. Therefore, novel siRNA delivery vectors that could promote efficacy need to be developed urgently. Here, we designed high-surface gold nanostars (GNS-P) which are decorated with cationic tumor-targeting peptide as an efficient and functional siRNA delivery nanoplatform for tumor the

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Munisso, Maria Chiara, Atsushi Mahara, Yoichi Tachibana, Jeong Hun Kang, Satoshi Obika, and Tetsuji Yamaoka. "Hepatocyte-Specific Gene Delivery with Galactose-Bearing Cationic Polymers with Different Molecular Structures." Advances in Science and Technology 86 (September 2012): 86–91. http://dx.doi.org/10.4028/www.scientific.net/ast.86.86.

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Since the promising virus -based gene therapies are often limited by problems such as the immunity of virus itself, the development of an efficient non-viral vector is of prime importance. For this reason, several synthetic nonviral polymeric carriers including cationic sequences have been molecularly designed. It is well known that the polymeric carriers with some cationic groups buffer the endosomal pH resulting in the enhanced transfection efficiency, but also in a relatively high toxicity. In the last decades, the polymers bearing pendant carbohydrates (glycopolymers) was proved to have re

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Cao, Ye, Yang Fei Tan, Yee Shan Wong, Melvin Wen Jie Liew, and Subbu Venkatraman. "Recent Advances in Chitosan-Based Carriers for Gene Delivery." Marine Drugs 17, no. 6 (2019): 381. http://dx.doi.org/10.3390/md17060381.

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Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic genes need to overcome several physiological and intracellular barriers in order, to reach the target cells. Over the years, efforts have been dedicated to develop efficient gene delivery vectors to overcome these systemic barriers. Chitosan, a versatile polysaccharide, is an attractive non-viral vecto

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Bragonzi, A., G. Dina, A. Villa, et al. "Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs." Gene Therapy 7, no. 20 (2000): 1753–60. http://dx.doi.org/10.1038/sj.gt.3301282.

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Hattori, Yoshiyuki, and Yoshie Maitani. "Low-Molecular-Weight Polyethylenimine Enhanced Gene Transfer by Cationic Cholesterol-Based Nanoparticle Vector." Biological & Pharmaceutical Bulletin 30, no. 9 (2007): 1773–78. http://dx.doi.org/10.1248/bpb.30.1773.

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Ouyang, Defang, Hong Zhang, Dirk-Peter Herten, Harendra S. Parekh, and Sean C. Smith. "Structure, Dynamics, and Energetics of siRNA−Cationic Vector Complexation: A Molecular Dynamics Study." Journal of Physical Chemistry B 114, no. 28 (2010): 9220–30. http://dx.doi.org/10.1021/jp911906e.

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Fominaya, Jes�s, Mar�a Gasset, Rosana Garc�a, Fernando Roncal, Juan Pablo Albar, and Antonio Bernad. "An optimized amphiphilic cationic peptide as an efficient non-viral gene delivery vector." Journal of Gene Medicine 2, no. 6 (2000): 455–64. http://dx.doi.org/10.1002/1521-2254(200011/12)2:6<455::aid-jgm145>3.0.co;2-o.

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Jafari, Amin, Nika Rajabian, Guojian Zhang та ін. "PEGylated Amine-Functionalized Poly(ε-caprolactone) for the Delivery of Plasmid DNA". Materials 13, № 4 (2020): 898. http://dx.doi.org/10.3390/ma13040898.

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As a promising strategy for the treatment of various diseases, gene therapy has attracted increasing attention over the past decade. Among various gene delivery approaches, non-viral vectors made of synthetic biomaterials have shown significant potential. Due to their synthetic nature, non-viral vectors can have tunable structures and properties by using various building units. In particular, they can offer advantages over viral vectors with respect to biosafety and cytotoxicity. In this study, a well-defined poly(ethylene glycol)-block-poly(α-(propylthio-N,N-diethylethanamine hydrochloride)-ε

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Lv, Yue, Jiaoqin Xue, Pengfei Cui, and Lin Qiu. "Spermine Significantly Increases the Transfection Efficiency of Cationic Polymeric Gene Vectors." Pharmaceutics 17, no. 1 (2025): 131. https://doi.org/10.3390/pharmaceutics17010131.

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Non-viral vectors have gained recognition for their ability to enhance the safety of gene delivery processes. Among these, polyethyleneimine (PEI) stands out as the most widely utilized cationic polymer due to its accessibility. Traditional methods of modifying PEI, such as ligand conjugation, chemical derivatization, and cross-linking, are associated with intricate preparation procedures, limited transfection efficiency, and suboptimal biocompatibility. In this investigation, enhanced transfection efficiency was achieved through the straightforward physical blending of PEI carriers with sperm

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Ullah, Ihsan, Jing Zhao, Shah Rukh, et al. "A PEG-b-poly(disulfide-l-lysine) based redox-responsive cationic polymer for efficient gene transfection." Journal of Materials Chemistry B 7, no. 11 (2019): 1893–905. http://dx.doi.org/10.1039/c8tb03226b.

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Alamoudi, Abdullah A., Paula A. Méndez, David Workman, Andreas G. Schätzlein, and Ijeoma F. Uchegbu. "Brain Gene Silencing with Cationic Amino-Capped Poly(ethylene glycol) Polyplexes." Biomedicines 10, no. 9 (2022): 2182. http://dx.doi.org/10.3390/biomedicines10092182.

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Therapeutic gene silencing in the brain is usually achieved using highly invasive intracranial administration methods and/or comparatively toxic vectors. In this work, we use a relatively biocompatible vector: poly(ethylene glycol) star-shaped polymer capped with amine groups (4APPA) via the nose to brain route. 4APPA complexes anti- itchy E3 ubiquitin protein ligase (anti-ITCH) siRNA to form positively charged (zeta potential +15 ± 5 mV) 150 nm nanoparticles. The siRNA-4APPA polyplexes demonstrated low cellular toxicity (IC50 = 13.92 ± 6 mg mL−1) in the A431 cell line and were three orders of

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Miller, Andrew. "The Problem with Cationic Liposome / Micelle-Based Non-Viral Vector Systems for Gene Therapy." Current Medicinal Chemistry 10, no. 14 (2003): 1195–211. http://dx.doi.org/10.2174/0929867033457485.

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Fein, David E., Maria P. Limberis, Sean F. Maloney, Jack M. Heath, James M. Wilson, and Scott L. Diamond. "Cationic Lipid Formulations Alter the In Vivo Tropism of AAV2/9 Vector in Lung." Molecular Therapy 17, no. 12 (2009): 2078–87. http://dx.doi.org/10.1038/mt.2009.173.

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Guo, Xin Dong, Fanny Tandiono, Nikken Wiradharma, et al. "Cationic micelles self-assembled from cholesterol-conjugated oligopeptides as an efficient gene delivery vector." Biomaterials 29, no. 36 (2008): 4838–46. http://dx.doi.org/10.1016/j.biomaterials.2008.07.053.

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De Simone, Simeone, Francesco Di Capua, Ludovico Pontoni, Andrea Giordano, and Giovanni Esposito. "Impact of Cationic Polyelectrolyte Addition on Mesophilic Anaerobic Digestion and Hydrocarbon Content of Sewage Sludge." Fermentation 8, no. 10 (2022): 548. http://dx.doi.org/10.3390/fermentation8100548.

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The agricultural spreading of treated sewage sludge is a valid strategy in terms of circular economy for the management of this nutrient-rich waste. Anaerobic digestion (AD) can be applied to stabilize and hygienize sewage sludge, making it suitable for agricultural reuse, while producing biogas to be utilized as an energy vector. However, the presence of contaminants, including petroleum hydrocarbons, could limit the widespread agricultural utilization of sewage sludge. In this context, the impact of dewatering agents, such as cationic polyelectrolytes, on AD efficiency and hydrocarbon biodeg

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Guerra-Rebollo, Marta, María Stampa, Miguel Ángel Lázaro, Anna Cascante, Cristina Fornaguera, and Salvador Borrós. "Electrostatic Coating of Viral Particles for Gene Delivery Applications in Muscular Dystrophies: Influence of Size on Stability and Antibody Protection." Journal of Neuromuscular Diseases 8, no. 5 (2021): 815–25. http://dx.doi.org/10.3233/jnd-210662.

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Background: Duchenne Muscular Dystrophy (DMD) is one of the most common muscular dystrophies, caused by mutated forms of the dystrophin gene. Currently, the only treatment available is symptoms management. Novel approximations are trying to treat these patients with gene therapy, namely, using viral vectors. However, these vectors can be recognized by the immune system decreasing their therapeutic activity and making impossible a multidose treatment due to the induction of the humoral immunity following the first dose. Objective: Our objective is to demonstrate the feasibility of using a hybri

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Ghodke, Sharwari, Prajakta Mahajan, Kritika Gupta, Chilukuri Ver Avadhani, Prajakta Dandekar та Ratnesh Jain. "Biodegradable Polyester of Poly (Ethylene glycol)-sebacic Acid as a Backbone for β -Cyclodextrin-polyrotaxane: A Promising Gene Silencing Vector". Current Gene Therapy 19, № 4 (2019): 274–87. http://dx.doi.org/10.2174/1566523219666190808094225.

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Abstract:

Background: Polyrotaxane, a macromolecular interlocked assembly, consisting of cyclodextrin has excellent inclusion capabilities and functionalization capacity, which makes it a versatile material as a vector for gene delivery applications. Objective: A biodegradable linear aliphatic polyester axle composed of Polyethylene Glycol (PEG) and Sebacic Acid (SA) was used to fabricate the β-Cyclodextrin (β-CD) based polyrotaxane as a cationic polymeric vector and evaluated for its potential gene silencing efficiency. Methods: The water-soluble aliphatic polyester was synthesized by the solvent ester

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Ravera, Mauro, Elisabetta Gabano, Ilaria Zanellato, Elena Perin, Aldo Arrais, and Domenico Osella. "Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes." Bioinorganic Chemistry and Applications 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2380540.

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Phenanthriplatin, that is, (SP-4-3)-diamminechlorido(phenanthridine)platinum(II) nitrate, an effective antitumor cationic Pt(II) complex, was loaded on negatively charged dextran sulfate (DS) as a model vector for drug deliveryviaelectrostatic interactions. The free complex and the corresponding conjugate withDSwere tested on two standard human tumor cell lines, namely, ovarian A2780 and colon HCT 116, and on several malignant pleural mesothelioma cell lines (namely, epithelioid BR95, mixed/biphasic MG06, sarcomatoid MM98, and sarcomatoid cisplatin-resistant MM98R). Thein vitroresults suggest

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Nakashima, Y., M. Yano, Y. Kobayashi, et al. "Endostatin gene therapy on murine lung metastases model utilizing cationic vector-mediated intravenous gene delivery." Gene Therapy 10, no. 2 (2003): 123–30. http://dx.doi.org/10.1038/sj.gt.3301856.

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Yue, Xinye, Wendi Zhang, Jinfeng Xing, et al. "Self-assembled cationic triblock copolymer mPEG-b-PDLLA-b-PDMA nanoparticles as nonviral gene vector." Soft Matter 8, no. 7 (2012): 2252. http://dx.doi.org/10.1039/c2sm07068e.

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Kim, Chong-Kook, Eun-Jeong Choi, Sung-Hee Choi, Jeong-Sook Park, Khawaja Hasnain Haider, and Woong Shick Ahn. "Enhanced p53 gene transfer to human ovarian cancer cells using the cationic nonviral vector, DDC." Gynecologic Oncology 90, no. 2 (2003): 265–72. http://dx.doi.org/10.1016/s0090-8258(03)00248-8.

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