Academic literature on the topic 'Caudharī'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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Journal articles on the topic "Caudharī"

Kirkman, Tim, Alice Sketcher, Vinicius de Morais Barroso, Kelly Ishida, Manuela Tosin, and Marcio Vinicius Bertacine Dias. "Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris." Acta Crystallographica Section D Structural Biology 79, no. 8 (2023). http://dx.doi.org/10.1107/s2059798323004709.

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Abstract:

Candida auris has emerged as a global health problem with a dramatic spread by nosocomial transmission and a high mortality rate. Antifungal therapy for C. auris infections is currently limited due to widespread resistance to fluconazole and amphotericin B and increasing resistance to the front-line drug echinocandin. Therefore, new treatments are urgently required to combat this pathogen. Dihydrofolate reductase (DHFR) has been validated as a potential drug target for Candida species, although no structure of the C. auris enzyme (CauDHFR) has been reported. Here, crystal structures of CauDHFR