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Dissertations / Theses on the topic 'Caveolina-1'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Zampier, Carolina da Paz. "Papel de caveolina-1 na produção de mediadores inflamatórios." Instituto Oswaldo Cruz, 2012. https://www.arca.fiocruz.br/handle/icict/7031.

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Submitted by Alessandra Portugal (alessandradf@ioc.fiocruz.br) on 2013-10-01T21:53:22Z No. of bitstreams: 1 Carolina da Paz Zampier.pdf: 2134379 bytes, checksum: d822f378a88e2cf44b02c5ea60f52ea0 (MD5)<br>Made available in DSpace on 2013-10-01T21:53:22Z (GMT). No. of bitstreams: 1 Carolina da Paz Zampier.pdf: 2134379 bytes, checksum: d822f378a88e2cf44b02c5ea60f52ea0 (MD5) Previous issue date: 2012<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>A caveolina-1 (Cav-1), uma proteína essencial para a formação de cavéolas, apresenta atividade na modulação da sinali

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2

Lagares, Tena Laura María. "Caveolina-1 en la progresión metastásica del Sarcoma de Ewing." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/145475.

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El sarcoma de Ewing (SE) es el segundo tumor óseo maligno infantil más frecuente y presenta una alta incidencia de enfermedad metastásica. Este tipo de tumores presentan una translocación génica característica que da origen a una proteína de fusión, normalmente EWS/FLI1. Esta proteína de fusión actúa como factor de transcripción aberrante, regulando la expresión de diferentes genes implicados en la iniciación, mantenimiento y progresión del tumor. Nuestro grupo describió como uno de estos genes diana a caveolina 1 (CAV1), describiendo además su papel determinante en el fenotipo maligno del SE,

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3

Díaz, Valdivia Natalia. "E-cadherina reduce la habilidad promotora de migración y metástasis de caveolina-1 por la disminución de la fosforilación de caveolina-1 en células metastásicas." Tesis, Universidad de Chile, 2016. http://repositorio.uchile.cl/handle/2250/140680.

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Tesis para optar al grado de Doctora en Bioquímica<br>El cáncer corresponde a la segunda causa de muerte en Chile y el mundo, pero los pacientes con cáncer no mueren debido al crecimiento del tumor primario, sino a la diseminación de las células tumorales y posterior colonización de éstas en nuevos órganos o metástasis. En términos generales, el cáncer es la consecuencia de un proceso multifactorial que lleva a la transformación progresiva de células normales en células altamente malignas. La amplia variedad de fenotipos del cáncer se debe a la manifestación de alteraciones esenciales e

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4

González, Muñoz Elena. "Papel de las caveolas/caveolina-1 en la fisiologia del adipocito." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1023.

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La función de las caveolas y de la caveolina in vivo ha sido motivo de controversia, de hecho se han implicado en procesos de endocitosis y transcitosis, transporte de colesterol y ácidos grasos, regulación de procesos de transducción de señales y tumorigénesis (Liu et al., 2002). Sin embargo, la generación de los ratones KO de caveolina-1 (Drab et al., 2001; Razani et al., 2001a) mostraba que estos ratones eran perfectamente viables y fértiles, aunque estudios posteriores relacionaban a caveolina-1 con la homeostasis lipídica (Razani et al., 2002a).<br/><br/>A partir de estos antecedentes, el

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5

Mateo, Lozano Silvia. "Sarcoma de Ewing: nuevas aproximaciones terapéuticas y búsqueda de dianas biológicas del oncogén EWS/FLI-1." Doctoral thesis, Universitat Autònoma de Barcelona, 2007. http://hdl.handle.net/10803/3571.

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La familia de tumores del sarcoma de Ewing (ESFT) incluye un grupo heterogéneo de neoplasias caracterizadas por la presencia de células redondas de pequeño tamaño con mínima evidencia morfológica de diferenciación. ESFT es el segundo tumor óseo más frecuente, afectando fundamentalmente a niños y adolescentes. A pesar del uso de terapias agresivas combinando quimioterapia, radioterapia y cirugía, la supervivencia de pacientes con metástasis es aproximadamente del 30%, mientras que en ausencia de enfermedad metastásica alcanza valores del 70 %. Debido a esto, son necesarias nuevas aproximaciones

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6

Sáinz, Jaspeado Miguel Guillermo. "Regulación del aporte vascular en el Sarcoma de Ewing: Papel de la Caveolina-1." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/107820.

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Como otros tumores sólidos, el sarcoma de Ewing (SE) requiere de un aporte vascular adecuado que permita nutrir y oxigenar a las células tumorales. En el SE, la vascularización tumoral se encuentra caracterizada principalmente por los procesos de vasculogenesis, mimetismo vascular y angiogénesis. Considerando la participación de CAV1 en el aporte vascular, nos planteamos demostrar que CAV1 juega un papel importante en el desarrollo vascular de la enfermedad. Estableciendo tres nuevos modelos de baja expresión de CAV1 en células se SE (RDES, SKES1 y TC71), fue posible observar la reducción e

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7

Ilha, Mariana. "Papel da caveolina-1 na capacidade de migração e proliferação de células estreladas hepáticas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/117581.

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A fibrose hepática é uma característica comum de diversas doenças crônicas do fígado e é caracterizada pela deposição excessiva de matriz extracelular no órgão. Em última instância, essa alteração anormal do parênquima hepático acarreta em hipertensão portal, cirrose e insuficiência do fígado, o que pode levar o paciente à morte. As células estreladas hepáticas (HSC) participam ativamente deste processo, modificando seu fenótipo quiescente, rico em gotas lipídicas no citoplasma, para o fenótipo ativado, em resposta a um insulto hepático. A linhagem GRX é um modelo de HSC ativadas. As caveolas

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8

Cruz, Gómez Sebastián Matías. "Rol de caveolina-1 en la quimiotaxis de las células dendríticas hacia los nódulos linfáticos." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/150211.

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Tesis para optar al grado de Magister en Bioquímica<br>Las células dendríticas (DCs) son células presentadoras de antígeno capaces de capturar y procesar antígenos que luego son presentados a linfocitos T específicos en órganos linfoides. Para activar a los linfocitos T, las DCs deben pasar por un proceso de maduración y migración hacia los nódulos linfáticos. Para esto, las DCs deben percibir el rastro de quimioquinas como CCL21, a través de receptores como CCR7, que las dirigen hacia los vasos linfáticos y finalmente al nódulo linfático. Dicho proceso se denomina quimiotaxis y es dependiente

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9

Sanhueza, Muñoz Carlos Joaquín. "Caveolina-1 reduce la transcripción dependiente de hif1α en un mecanismo dependiente del óxido nítrico en células tumorales". Tesis, Universidad de Chile, 2013. http://repositorio.uchile.cl/handle/2250/114871.

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Doctor en Farmacología<br>Autorizada por el autor, pero con restricción para ser publicada a texto completo en el Portal de Tesis Electrónicas, hasta diciembre de 2018<br>El cáncer es la 2° causa de muerte en Chile. El desarrollo del cáncer se ha propuesto que es consecuencia de la pérdida de función de los genes supresores de tumores beneficiando la acción de los oncogenes (genes que promueven el crecimiento de tumores). La activación del Factor inducible por hipoxia 1α (HIF1α) en un ambiente reducido en oxígeno (hipoxia) o por óxido nítrico (NO), permiten la proliferación y adaptación metabó

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Díaz, Morales María Inés. "Rol de la respuesta a proteínas mal plegadas en la actividad supresora de tumores de Caveolina-1." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/136641.

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Doctora en Bioquímica<br>Autor no autoriza el acceso a texto completo de su documento<br>El cáncer es la segunda causa de muerte a nivel mundial y en Chile luego de las enfermedades cardiovasculares. Importantemente, las muertes por cáncer van en aumento. Los avances más recientes en el entendimiento de las vías de señalización involucradas en cáncer, ha permitido la identificación de marcadores tempranos y tardíos de la carcinogénesis, los cuales son fundamentales para el diagnóstico y la prognosis del paciente. Basados en estos descubrimientos, existen disponibles nuevas terapias para el tra

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11

Lobos, González Lorena. "E-cadherina potencia a caveolina-1 como supresor de tumores y reduce su efecto promotor de metástasis." Tesis, Universidad de Chile, 2011. http://repositorio.uchile.cl/handle/2250/112023.

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Tesis presentada a la Universidad de Chile para optar al grado de Doctor en Bioquímica<br>Caveolina-1 es una proteína de membrana esencial en la formación de caveolas, participa en el transporte de colesterol, actúa como proteína de andamiaje en señalización y ha sido descrita como un supresor de tumores. Por otro lado, la presencia de Caveolina-1 juega un rol esencial en la polarización celular durante el proceso migratorio, ya que controla la localización de moléculas de señalización y regula la activación de proteínas que participan en migración. Sin embargo, no sólo la presencia de Caveol

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Hirsch, Gabriela Elisa. "Efeitos do γ-orizanol e extrato hidroalcólico de Thuya occidentalis sobre linhagens de câncer de próstata responsivas e não-responsivas a andrógenos". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/141254.

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O câncer de próstata é a segunda causa de morte entre homens no Brasil. É tipo um câncer de crescimento lento, podendo levar anos para o tumor atingir 1 cm3, porém, em alguns casos ele pode se espalhar pelo corpo, sendo o osso o principal sítio de metástase. No estágio de desenvolvimento do câncer conhecido como metástase, o principal tratamento consiste em terapia de restrição andrógena, levando as células prostáticas a pararem de proliferar, uma vez que elas crescem em resposta a presença de hormônios andrógenos, como a diidrotestosterona e testosterona. Porém, em alguns casos, as células pr

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Campos, González América Vanessa. "Estudio del rol pro-metastásico de Caveolina-1 en vesículas extracelulares de líneas celulares de cáncer de mama metastásico." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/172698.

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Tesis presentada a la Universidad de Chile para optar al grado de Doctora en Bioquímica<br>El cáncer de mama corresponde a una de las neoplasias malignas que más se asocia a mortalidad en el género femenino a nivel mundial. Aunque su incidencia ha disminuido gracias a la implementación de mamografías de exploración y aplicación de terapias adyuvantes, esta disminución no parece ser suficiente, ya que el desarrollo de metástasis aún sigue siendo responsable de más del 90% de las muertes asociadas a cáncer de mama, entre otros tipos de cáncer. La progresión de células tumorales hacia un estado

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Rodríguez, González Diego Alejandro. "Caveolina-1 inhibe la proliferacion y promueve la muerte celular mediante la regulacion negativa de la ciclooxigenasa-2 y survivina." Tesis, Universidad de Chile, 2009. http://repositorio.uchile.cl/handle/2250/110537.

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Troiano, Jéssica Antonini. "Avaliação de mecanismos de modificação pós-traducional da óxido nítrico sintase endotelial (eNOS) associados a biodisponibilidade do óxido nítrico em artérias de ratas espontaneamente hipertensas (SHR) ao final da prenhez /." Araçatuba, 2019. http://hdl.handle.net/11449/182077.

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Orientador: Cristina Antoniali Silva<br>Banca: Fernando Silva Carneiro<br>Banca: Carlos Alan Candido Dias Junior<br>Banca: Graziela Scalianti Ceravolo<br>Banca: Angela de Castro Resende<br>Resumo: A redução da reatividade vascular à fenilefrina (PE) em aorta de ratas espontaneamente hipertensas (SHR) ao final da prenhez é dependente de maior produção e/ou maior biodisponibilidade de óxido nítrico (NO), consequente do aumento da fosforilação da enzima óxido nítrico sintase endotelial (eNOS) via PI3K/Akt. A glicosilação do tipo N-acetil-glucosamina (O-GlcNAc) é uma modificação pós-traducional qu

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Potje, Simone Regina [UNESP]. "Efeito vasorelaxante do doador de óxido nítrico [Ru(terpy)(bdq)NO]3+ (TERPY) em artéria de resistência e sua interação com a óxido nítrico sintase endotelial (eNOS) de ratos espontaneamente hipertensos (SHR)." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/148587.

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Submitted by SIMONE REGINA POTJE null (simonepotje@hotmail.com) on 2017-01-20T14:12:22Z No. of bitstreams: 1 Tese Final Potje et al., 2017.pdf: 2363609 bytes, checksum: 76652ad37a98422f380b06f5e4c841b9 (MD5)<br>Approved for entry into archive by Juliano Benedito Ferreira (julianoferreira@reitoria.unesp.br) on 2017-01-24T18:03:20Z (GMT) No. of bitstreams: 1 potje_sr_dr_araca.pdf: 2363609 bytes, checksum: 76652ad37a98422f380b06f5e4c841b9 (MD5)<br>Made available in DSpace on 2017-01-24T18:03:20Z (GMT). No. of bitstreams: 1 potje_sr_dr_araca.pdf: 2363609 bytes, checksum: 76652ad37a98422f380b06

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Kobayashi, Priscila Emiko. "Expressão gênica e proteica de APC, E-caderina, β-catenina e Caveolina-1 no processo carcinogênico da próstata canina e suas metástases". Botucatu, 2016. http://hdl.handle.net/11449/134378.

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Orientador: Renée Laufer Amorim<br>Resumo: As alterações na expressão de E-caderina, -catenina, APC e Caveolina-1 nas células epiteliais prostáticas têm sido estudados em humanos como mecanismos relacionados com progressão tumoral, invasão e metástase. Estas proteínas estão envolvidas no processo de adesão celular e ativação da via WNT canônica. No cão, a perda da expressão proteica de E-caderina e a translocação da -catenina da membrana para o citoplasma/núcleo foram descritas anteriormente em lesões prostáticas caninas. No entanto, nenhum estudo correlacionou alterações de expressão dessas p

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Comajoan, von Arend Pau. "Efecte de l'administració de l'rt-PA en condicions isquèmiques in vitro i in vivo: Cav-1 com a potencial biomarcador de volum d'infart." Doctoral thesis, Universitat de Girona, 2019. http://hdl.handle.net/10803/669184.

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Recombinant tissue plasminogen activator (rt-PA) is currently the only FDA-approved drug for the treatment of acute ischaemic stroke. However, the application of this therapy is limited to <5-7% of patients due to the associated increased risk of haemorrhagic transformation (HT). Although it is known that HT is related to rt-PA-induced blood brain barrier (BBB) disruption, the underlying mechanisms are not well established. The obtained results show that long-term studies are needed to elucidate time-dependent molecular mechanisms associated to BBB breakdown, and to explore protective BBB ther

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Díaz, Fuentes Jorge Esteban. "Caveolina-1 favorece la activación de rab5 promoviendo la migración y la activación del eje p85α/tiam1/rac-1 en células de cáncer metastásico y en un modelo de metástasis in vivo en ratones c57bl/6". Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/136775.

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Doctor en Bioquímica<br>El cáncer constituye una de las principales causas de muerte en Chile y el mundo. Particularmente, la agresividad de esta enfermedad subyace en la diseminación de las células tumorales hacia otros tejidos, fenómeno conocido como metástasis. La metástasis es un proceso multifactorial, siendo la migración celular una de las etapas más relevantes. Caveolina-1 es una proteína de membrana que en etapas avanzadas del cáncer aumenta su expresión y promueve la migración celular y metástasis. En este contexto, Caveolina-1 ha sido asociada a un conjunto de cambios morfológi

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Chen, Hung-Chih. "Functions of Caveolin-1 and Caveolin-3 in muscular dystrophy." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4739/.

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Duchenne muscular dystrophy (DMD) is an X chromosome-linked disease caused by the absence of the sarcolemmal protein dystrophin. The skeletal muscles of DMD have disrupted dystrophin-glycoprotein complex (DGC) and impaired sarcolemma integrity. In this study, we show that clonally derived dystrophin-deficient myoblasts PD50A are differentiation impaired. Coculture with osteoblasts improves the differentiation efficiency of PD50A myoblasts. We also establish that supplementation of combinations of IGF-1/IGF-2, IGF-1/LIF and IGF- 2/LIF in cultured PD50A myoblasts ameliorates the differentiation

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Chand, Sourabh. "Caveolin-1 in renal disease." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7824/.

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Renal disease is a major global public health issue that affects 10% of the general population with premature morbidity and mortality related to cardiovascular disease and infection. Interstitial fibrosis is a common hallmark of progressive kidney dysfunction. There remains a stubborn discrepancy in identifying which patients suffer adverse events because of their disease or resulting treatment. Investigation in patient genome variation may explain this discrepancy. Caveolin-1 is the essential structural protein for caveolae that are ubiquitously distributed in fibroblasts, endothelial and epi

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Day, Elizabeth Helen. "Caveolin-1 involvement in prostate cancer." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555622.

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Caveolin-l (Cav-l) is an important component of plasma membrane caveolae and orchestrates cell signalling in the regulation of proliferation and apoptosis. Unlike many cancers, prostate cancer cells demonstrate elevated levels of cav-l expression which has been linked to Gleason scoring and aggression. A loss of cav-l, with siRNA, in an advanced prostate cancer cell line (PC-3) caused a significant increase in PI positive cells combined with reduced proliferation. Both Akt and ERK signalling showed altered functioning under these conditions and may orchestrate these effects. Such an effect was

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Honeyman, Brian. "The role of cavin-1 and caveolin-1 in breast cancer." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11016.

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Thesis (Ph.D.)--Boston University<br>Caveolae are small invaginations on the plasma membrane of a variety of tissue types and are formed by the caveolin (1 and 2) and cavin (1-3) proteins families. Physiological roles implicated for caveolae include vesicular trafficking, signal transduction, cell adhesion, and mechanosensation. Over 20 years ago, caveolin-1, a small integral membrane protein, was observed to be the major tyrosine phosphorylation target in cells transformed by the Src oncogene. Subsequently its expression has been widely studied in a variety of cancers where it has been shown,

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Mattsson, Charlotte L. "Role of caveolin-1 in brown adipose tissue." Doctoral thesis, Stockholm : The Wenner-Gren Institute, Stockholm University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-37125.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2010.<br>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 1: Manuscript. Paper 3: Manuscript. Paper 4: Manuscript. Härtill 4 uppsatser.

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Baggett, Ariele. "The Effects of Caveolin-1 on Mitochondrial Dynamics." Master's thesis, Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/495857.

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Biomedical Sciences<br>M.S.<br>Cardiovascular disease (CVD) is the leading global cause of death. Coronary Artery Disease (CAD) is a grouping of the most common cardiovascular diseases and is the current leading cause of death in developed countries. Treatments for CAD include pharmaceuticals as well as surgical interventions such as percutaneous coronary intervention (PCI) and coronary artery bypass grafting. However, these treatments do not completely remove the risk of adverse outcomes. Endothelial dysfunction is the underlying cause of CAD and is initiated by the chronic inflammation of th

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Basu, Roy Upal Kunal. "Regulation and Function of Caveolin-1 in Colorectal Carcinogenesis." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194031.

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Colon cancer is the second leading cause of cancer deaths in the United States of America. It is caused by the accumulation of mutations in tumor suppressors and oncogenes. The APC tumor suppressor is mutated in most diagnosed cases of colorectal cancer. Mutations in the K-RAS oncogene occur at later stages of colon cancer progression. In the present study, the transcriptional regulation of a novel target of these two genes, caveolin-1, was studied. Caveolin-1 is transcriptionally regulated by the APC tumor suppressor gene, via induction of its inducer, FOXO1 and the suppression of its transcr

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Wong, Wing-sum Winnie, and 王詠心. "Role of caveolin-1 in multidurg resistance in hepatocellularcarcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46632001.

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Tse, Yuk-ting Edith, and 謝玉婷. "Expression and function of caveolin-1 in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45984554.

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Wong, Kevin L. "Caveolae and Caveolin-1 are important for Vitamin D signalling." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37086.

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The most active form of Vitamin D, 1alpha,25(OH)2D3, modulates cells via receptor mediated mechanisms. While studies have elucidated the pathway via the classical nuclear Vitamin D Receptor (VDR), little is known about the membrane-associated Vitamin D Receptor (ERp60). Caveolae and its characteristic protein Caveolin-1 have been involved in many signaling pathways due to its specific structure and physical configuration. Other studies have shown that many components of the Vitamin D pathway have been found in caveolae. This study hypothesizes that caveolae and Caveolin-1 are important for the

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Dong, Shuai. "The Na/K-ATPase/Caveolin-1 Interaction Regulates Cell Growth." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1305223012.

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Simões, Francisco Manuel de Carvalho. "Cavin 1 and cavin 2 roles on adipocyte cell function." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6568.

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Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina<br>Caveolae are a specialized type of lipid rafts found in numerous cell types. These structures have been implicated as playing a role in a variety of metabolic regulation processes and are typically characterized by their association with the caveolin and cavin protein families. Caveolae are particularly enriched in adipocytes and here we analyze the effects of cavin 1 and cavin 2 knockdown in adipocyte functioning. We obtained several multiclonal mouse 3T3-L1 cell lines with reduced expression of cavin 1 or cav

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Hernandez, Mark J. "Caveolin-1 A scaffold for microcompartmental organization of membrane-associated glycolysis." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/6007.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "August 2007" Includes bibliographical references.

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Wong, Yuen-sze Sivia, and 王苑斯. "Role of hypoxia-induced upregulation of caveolin-1 in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46944333.

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Harris, Tanoya L. "Ouabain Regulates Caveolin-1 Vesicle Trafficking by a Src-Dependent Mechanism." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1333732028.

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35

Gutteridge, Robert. "Caveolin-1 is a modulator of clonogenicity in renal cell carcinoma." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/91911/.

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Renal cell carcinoma (RCC) represents a group of aggressive tumours of the kidney. These tumours have a high propensity for metastasis and are extremely treatment refractive after disease relapse. Therefore, the identification of new therapeutic targets is of great importance. One such potential target for therapy are cancer stem cells (CSCs). CSCs are populations of cells imbued with a stem cell-like phenotype capable of driving tumour formation, metastasis and chemoresistance. As such, reliable methods for the identification of CSC populations and defining targets important to their function

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Mir, Kiran D. "The rotavirus nonstructural protein 4 (NSP4) interacts with both the N- and C- termini of caveolin-1." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3976.

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Rotavirus (RV) is an etiologic agent of viral gastroenteritis in children and infants worldwide, accounting for an estimated 500,000 deaths annually. NSP4, the first described viral enterotoxin, contributes to RV pathogenesis by mobilizing intracellular calcium through multiple mechanisms that promote abnormal ion transport and subsequent secretory diarrhea. NSP4 and the enterotoxic peptide 114-135 preferentially interact with model membranes mimicking caveolae in lipid composition and radius of curvature. Our laboratory has recently reported the colocalization and coimmunoprecipitation of NSP

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Chikani, Gentle P. "LEPTIN RECEPTORS IN CAVEOLAE: REGULATION OF LIPOLYSIS IN 3T3-L1 ADIPOCYTES." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_theses/382.

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The present study has tested the hypothesis that leptin receptors are localized in caveolae and that caveolae are involved in the leptin-induced stimulation of lipolysis in 3T3-L1 adipocytes. Leptin, a peptide hormone, is secreted primarily by adipocytes and has been postulated to regulate food intake and energy expenditure via hypothalamic-mediated effects. Exposure to leptin increases the lipolytic activity in 3T3-L1 adipocytes. We isolated caveolae from 3T3-L1 adipocytes using a detergent free sucrose gradient centrifugation method. Leptin receptors were localized in the same gradient fract

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Gaudreault, Sophie B. "Caveolin-1 in synaptic signalling and neuronal plasticity : implications for Alzheimer's disease." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85069.

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Increasing evidence indicates that cholesterol plays a central role in the pathophysiology of Alzheimer's disease (AD). Caveolin is a cholesterol-binding membrane protein involved in cellular cholesterol homeostasis and signalling. The global working hypothesis of the present project was to investigate on a possible role for caveolin in the pathophysiological events underlying AD.<br>More specifically, a first study was conducted to evaluate potential changes in the amount of brain caveolin in autopsy-confirmed AD and age-matched control subjects. Using rodents, the effect of age and ap

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Links, Philip Harold. "The molecular cloning, cellular expression, and functional study of human caveolin-1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/MQ57132.pdf.

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Petriello, Michael C. "ROLE OF CAVEOLIN-1 AND NRF2 IN NUTRITIONAL MODULATION OF PCB TOXICITY." UKnowledge, 2015. http://uknowledge.uky.edu/toxicology_etds/11.

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Cardiovascular disease is the leading cause of mortality in Western societies and is linked to multiple modifiable risk factors including lifestyle choices. Emerging evidence implicates exposure to persistent environmental pollutants, such as polychlorinated biphenyls (PCBs), as a risk factor for the development or progression of cardiovascular disease. To reduce disease risks, it is critical to identify sensible means of biomedically reducing the toxicity of persistent organic pollutants and related environmental stressors. First, we tested a hypothesis that endothelial cell inflammation and

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Pancotti, Fabia <1984&gt. "Role of caveolin-1 in the proliferation of solid tumours in vitro." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3313/.

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Caveolin-1 (Cav-1), the essential structural constituent of caveolae, which are flask-shaped invaginations of the plasma membrane, has been found to play a key role in the modulation of cell proliferation and cancer development. It seems to act as an oncosuppressor or a promoter of growth, depending on the histotype, stage and grade of each tumour. The aim of this study was to analyze the effects of Caveolin-1 gene silencing on the proliferation of human lung cancer and osteosarcoma in vitro. Our data show that Cav-1 silencing blocks the growth in both metastatic lung cancer cell lines an

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Yu, Lingli. "Nerve Growth Factor Signaling from Membrane Microdomain to Nucleus : Differential Regulation by Caveolins." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00796393.

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At the plasma membrane, both NGF receptors have been shown to localized to lipid rafts, specific subdomains that are enriched in cholesterol, sphingolipids and the presence of caveolin proteins (Cav1 and/or Cav2). The focus of this work is on this membrane microenvironment mediated modulation of NGF signaling which via two receptors: p75NTR and TrkA. In the present work we found that overexpression of Cav-1 in mouse dorsal root ganglia neurons significantly impacted neurite extension. Similarly, overexpression of Cav-1 in PC12 cells strongly inhibits their ability to grow neurites in response

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Steiner, Isabel. "Epigenetische und angiogenetische Veränderungen beim klinisch lokalisierten Prostatakarzinom." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16652.

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Im Fokus der Dissertation stand die Evaluierung molekularer Möglichkeiten zur Findung geeigneter Biomarker für das Prostatakarzinom (PCa). Zunächst wurde die epigenetische Promotormethylierung der Gene GSTP1, RARbeta2, APC und PITX2 im Hinblick eines möglichen Methylierungsfeldeffektes untersucht. Die RARβ2-Promotormethylierung konnte als potentieller Marker zur Tumorvorhersage im histologisch normal erscheinenden Gewebe bestimmt werden. GSTP1 zeigte eine äußerst spezifische Tumormethylierung, was dessen diagnostisches Potenzial unterstreicht. Die Methylierung korrelierte zudem mit pathologisc

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Moreno, Càceres Joaquim. "The role of Caveolin-1 in the TGF-β-induced signalling in hepatocytes". Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396239.

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The transforming growth factor-beta (TGF-β) is a cytokine involved in many physiological and pathological processes. Its dual role has been described in the liver, where it can either induce pro- or anti-apoptotic signals. The survival signals are in great extent mediated by the epidermal growth factor (EGFR). Caveolin-1 (CAV1) is a structural protein of the plasma membrane involved in the regulation of different signalling processes and receptor trafficking, as the TGF-β ones (TβRs). Traditionally, CAV1 has been associated with downregulation of the TGF-β signalling, given its presence in SMA

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Li, Qiong Medical Sciences Faculty of Medicine UNSW. "Lipid analysis of wild type and caveolin-1 knock out mouse embryonic fibroblasts." Awarded by:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41552.

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The aim of this project is to characterise the levels of cholesterol and phospholipid in cell homogenates, plasma membranes and isolated membrane domains from wildtype (WT) and caveolin-l knock-out (Cav-1-/ -) mouse embryonic fibroblasts (MEFs). Quantitative lipid analysis was developed for cholesterol by high-performance liquid chromatography (HPLC) and for glycerophospholipids (GPL) and sphingomyelin (SM) by electrospray ionisation mass spectrometry (ESI-MS). In the cell homogenates, by comparing WT to Cav-l-/- MEFs, it was found that the total cholesterol as well as the proportions of the

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Hausman, Natasha L. "The influence of caveolin-1 and ageing on resistance artery structure and function." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514440.

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Ageing is a risk factor for cardiovascular disease (CVD) and involves changes in the function and structure of resistance arteries. Membrane invaginations called caveolae are involved in cell signalling regulation, and can influence the active and passive properties of resistance arteries. Changes in caveolae and their structural protein caveolin-l have been implicated in CVD, therefore the role of caveolin-l in vascular ageing was investigated. Isolated resistance arteries from 3 and 12 month old wild-type (WT) and caveolin-l knock-out (KO) mice were examined. Mesenteric and femoral arteries

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Willière, Yan [Verfasser]. "Epitheliale und endotheliale Effekte der Caveolin-1-Deletion in der Niere / Yan Willière." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/120204266X/34.

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Meng, Fanrui. "Caveolin-1 and membrane domain regulation of focal adhesions and tumor cell migration." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59148.

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Caveolin-1 (Cav1), a key protein component of cell surface invagination caveolae and a major substrate of Src kinase, has been shown to be associated with cancer malignancy. Galectin-3 (Gal3), a galactose-specific lectin, forms oligomers and crosslinks N-glycans on cell surface to form the galectin lattice. Gal3 and Cav1 function together to regulate focal adhesion dynamics and tumor cell migration. In this thesis we hypothesize that the galectin lattice, Cav1 membrane domain organization (caveolae, Cav1 scaffolds) and Cav1 molecular motifs (tyrosine 14 phosphorylation (pY14), the caveolin sca

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Briand, Nolwenn. "Rôle de Caveoline-1 dans la contrôle de la capacité de stockage lipidique adipocytaire." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00827746.

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Les cavéolines et les protéines cavines forment le manteau d'invaginations membranaires appelées cavéoles. Dans le tissu adipeux (TA), ces structures sont très abondantes dans les adipocytes et les cellules endothéliales. Une perte d'expression de cavéoline-1 a pour conséquence une lipoatrophie sévère chez les souris invalidées pour ce gène (Cav1(-/-)), ce qui a conduit à suggérer un rôle important de Cav1 pour le contrôle de la capacité de stockage du TA. Par ailleurs, les souris Cav1(-/-) présentent des défauts vasculaires, phénotype totalement corrigé par une réexpression spécifique de Cav1

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Saxena, Sandeep. "Impact of y14 phosphorylation of caveolin-1 on its binding partners : a proteomic analysis." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58155.

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Caveolae, a special type of lipid-raft, are cave-like invaginations of plasma-membrane maintained and formed by Caveolins (Cav1, 2 and 3) and Cavin 1 and 2. Caveolae regulate various trafficking and signaling pathways. Cav1, a 178 amino acid protein has a Src-dependent tyrosine-14 phosphorylation site that regulates integrin signaling and focal adhesion dynamics, and a Caveolin Scaffolding Domain (CSD) that physically interacts with multiple proteins. Glutathione-S-transferase (GST) pull-downs and quantitative proteomics analysis (Maxquant) were performed using lysates from the DU145 prostat

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