Relevant bibliographies by topics / CBDP

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'CBDP'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "CBDP"

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Salbini, Maria, Alessandra Quarta, Fabiana Russo, Anna Maria Giudetti, Cinzia Citti, Giuseppe Cannazza, Giuseppe Gigli, Daniele Vergara, and Antonio Gaballo. "Oxidative Stress and Multi-Organel Damage Induced by Two Novel Phytocannabinoids, CBDB and CBDP, in Breast Cancer Cells." Molecules 26, no. 18 (September 14, 2021): 5576. http://dx.doi.org/10.3390/molecules26185576.

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Over the last few years, much attention has been paid to phytocannabinoids derived from Cannabis for their therapeutic potential. Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the most abundant compounds of the Cannabis sativa L. plant. Recently, novel phytocannabinoids, such as cannabidibutol (CBDB) and cannabidiphorol (CBDP), have been discovered. These new molecules exhibit the same terpenophenolic core of CBD and differ only for the length of the alkyl side chain. Roles of CBD homologs in physiological and pathological processes are emerging but the exact molecular mechanisms remain to be fully elucidated. Here, we investigated the biological effects of the newly discovered CBDB or CBDP, compared to the well-known natural and synthetic CBD (nat CBD and syn CBD) in human breast carcinoma cells that express CB receptors. In detail, our data demonstrated that the treatment of cells with the novel phytocannabinoids affects cell viability, increases the production of reactive oxygen species (ROS) and activates cellular pathways related to ROS signaling, as already demonstrated for natural CBD. Moreover, we observed that the biological activity is significantly increased upon combining CBD homologs with drugs that inhibit the activity of enzymes involved in the metabolism of endocannabinoids, such as the monoacylglycerol lipase (MAGL) inhibitor, or with drugs that induces the activation of cellular stress pathways, such as the phorbol ester 12-myristate 13-acetate (PMA).
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Breukels, Vincent, Wouter G. Touw, and Geerten W. Vuister. "Structural and dynamic aspects of Ca2+ and Mg2+ binding of the regulatory domains of the Na+/Ca2+ exchanger." Biochemical Society Transactions 40, no. 2 (March 21, 2012): 409–14. http://dx.doi.org/10.1042/bst20110742.

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Intracellular Ca2+ regulates the activity of the NCX (Na+/Ca2+ exchanger) through binding to the cytosolic CBD (Ca2+-binding domain) 1 and CBD2. In vitro studies of the structure and dynamics of CBD1 and CBD2, as well as studies of their kinetics and thermodynamics of Ca2+ binding, greatly enhanced our understanding of NCX regulation. We describe the fold of the CBDs in relation to other known structures and review Ca2+ binding of the different CBD variants from a structural perspective. We also report on new findings concerning Mg2+ binding to the CBDs and finally we discuss recent results on CBD1–CBD2 interdomain interactions.
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Tanaka, Takeshi, Shinsuke Fujiwara, Shingo Nishikori, Toshiaki Fukui, Masahiro Takagi, and Tadayuki Imanaka. "A Unique Chitinase with Dual Active Sites and Triple Substrate Binding Sites from the Hyperthermophilic Archaeon Pyrococcus kodakaraensis KOD1." Applied and Environmental Microbiology 65, no. 12 (December 1, 1999): 5338–44. http://dx.doi.org/10.1128/aem.65.12.5338-5344.1999.

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ABSTRACT We have found that the hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1 produces an extracellular chitinase. The gene encoding the chitinase (chiA) was cloned and sequenced. ThechiA gene was found to be composed of 3,645 nucleotides, encoding a protein (1,215 amino acids) with a molecular mass of 134,259 Da, which is the largest among known chitinases. Sequence analysis indicates that ChiA is divided into two distinct regions with respective active sites. The N-terminal and C-terminal regions show sequence similarity with chitinase A1 from Bacillus circulans WL-12 and chitinase from Streptomyces erythraeus (ATCC 11635), respectively. Furthermore, ChiA possesses unique chitin binding domains (CBDs) (CBD1, CBD2, and CBD3) which show sequence similarity with cellulose binding domains of various cellulases. CBD1 was classified into the group of family V type cellulose binding domains. In contrast, CBD2 and CBD3 were classified into that of the family II type. chiA was expressed inEscherichia coli cells, and the recombinant protein was purified to homogeneity. The optimal temperature and pH for chitinase activity were found to be 85°C and 5.0, respectively. Results of thin-layer chromatography analysis and activity measurements with fluorescent substrates suggest that the enzyme is an endo-type enzyme which produces a chitobiose as a major end product. Various deletion mutants were constructed, and analyses of their enzyme characteristics revealed that both the N-terminal and C-terminal halves are independently functional as chitinases and that CBDs play an important role in insoluble chitin binding and hydrolysis. Deletion mutants which contain the C-terminal half showed higher thermostability than did N-terminal-half mutants and wild-type ChiA.
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Prokofieva, D. S., V. I. Shmurak, E. A. Bodryakova, and N. G. Voitenko. "GENDER SPECIFIC CHANGES IN MOUSE BLOOD ESTRERASE PROFILE AT THE ACUTE INTOXICATION BY 2-(О-CRESYL)-4Н-1,3,2-BENZODIOXAPHOSPHORIN-2-OXIDE." Toxicological Review, no. 1 (February 28, 2017): 47–51. http://dx.doi.org/10.36946/0869-7922-2017-1-47-51.

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A comparative investigation of the esterase profiles of blood of mice of both genders exposed to various doses of 2-(o-crezyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) was made an hour after its percutaneous injection to animals. A lesser amount of esterase in males blood made them more susceptible to CBDP action as compared to females. It was shown that CBDP equally inhibits the activity of carboxyl esterase and butyryl choline esterase in blood serum of both male and female mice. Statistically significant differences in inhibition degree of enzymes between males and females were found out and therefore it is not recommended to use mixed groups of animals when performing testing of serine esterase inhibitors.
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Aslan-Parviz, Mahmood, Mansoor Omidi, Varahram Rashidi, Alireza Etminan, and Alireza Ahmadzadeh. "Evaluation of genetic diversity of durum wheat (Triticum durum desf.) genotypes using inter-simple sequence repeat (ISSR) and caat box-derived polymorphism (CBDP) markers." Genetika 52, no. 3 (2020): 895–909. http://dx.doi.org/10.2298/gensr2003895a.

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Evaluation of genetic diversity is the key principal for plant breeding, providing an opportunity to discover novel characters and alleles for breeders. In the present study, 69 durum wheat genotypes were investigated for genetic diversity using several CAAT box-derived polymorphism (CBDP) and inter-simple sequence repeat (ISSR) markers. Twelve CBDP and sixteen ISSR primers amplified a total of 115 and 160 polymorphic fragments with a mean of 9.58 and 10 fragments per primer, respectively. CBDP primers showed the higher mean values for informativeness parameters such as polymorphic information content (PIC), resolving power (Rp) and marker index (MI) in comparison with ISSR primers. The results of analysis of molecular variance (AMOVA) indicated that the highest proportion of genetic variance referred within populations. Furthermore, CBDP primers indicated high values for all genetic parameters. Besides, the highest values of genetic parameters including number of observed (Na) and effective alleles (Ne), Shannon?s information index (I) and Nei?s gene diversity (He) were estimated for Iranian durum wheat landraces. Cluster analysis based on each molecular technique classified all durum wheat genotypes into three main groups, so that the results of principal coordinate analysis (PCoA) supported the grouping patterns. As a result, the grouping pattern observed by ISSR primers was clearer than CBDP primers and grouped all samples based on their origins. However, Mantel?s coefficient correlation test illustrated the higher positive correlation (0.54) between both marker techniques. Hence, the use of these markers in combination with each other to evaluate the genetic diversity is recommended.
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Tomar, Priya, and C. P. Malik. "CDDP and CBDP as Novel Markers." LS: International Journal of Life Sciences 4, no. 2 (2015): 85. http://dx.doi.org/10.5958/2319-1198.2015.00012.3.

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Palikov, Viktor A., Yuliya A. Palikova, and Igor A. Dyachenko. "Study of protective properties of butyrylcholinesterase in acute anticholinesterase poisoning on BChE-KO and BALB/c mice." Research Results in Pharmacology 6, no. 1 (March 20, 2020): 41–45. http://dx.doi.org/10.3897/rrpharmacology.6.50941.

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Introduction: The article presents the results of studying the protective properties of recombinant human butyrylcholinesterase (rhBChE) in a model of acute anticholinesterase poisoning in mice knocked out for the BChE gene. Balb/c inbred mice were also used to demonstrate the important role of BChE. Materials and methods: In the study, BChE-ko and Balb/c mice were used. An organophosphorus compound (OPC) paraoxon was used as a toxic agent causing acute anticholinesterase poisoning. rhBChE was used as an antidote for OPC poisoning. To obtain rhBChE, an expression system based on CHO cell lines was chosen. In order to suppress BChE in Balb/c mice, a carboxyl esterase blocker cresylbenzodioxaphosphorin oxide (CBDP) was used. Two parameters were used to study the recovery after toxicity modeling: the end time of the animal tremor and the distance covered in open-field for 3 minutes. Results and discussion: The acute poisoning model using the CBDP blocker showed that the sensitivity of Balb/c mice increased significantly. The use of rhBChE against the background of CBDP allowed achieving 100% survival of animals with the minimum lethal dose of paraoxon. Knockout mice are expected to be more sensitive to the toxin, and the use of a biological trap in the form of rhBChE made it possible for 70% of the animals to survive with the minimum lethal dose of paraoxon. Besides, the use of rhBChE facilitated reducing the recovery time after OPC poisoning. Conclusion: The results of the study showed that the use of rhBChE as a protective agent in acute OPC poisoning significantly increased the survival of the animals and reduced the clinical manifestations of poisoning.
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Golliher, Alexandra E., Antonio J. Tenorio, Nina O. Dimauro, Nicolas R. Mairata, F. Omar Holguin, and William Maio. "Using (+)-carvone to access novel derivatives of (+)-ent-cannabidiol: The first asymmetric syntheses of (+)-ent-CBDP and (+)-ent-CBDV." Tetrahedron Letters 67 (March 2021): 152891. http://dx.doi.org/10.1016/j.tetlet.2021.152891.

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Giladi, Moshe, Su Youn Lee, Reuben Hiller, Ka Young Chung, and Daniel Khananshvili. "Structure-dynamic determinants governing a mode of regulatory response and propagation of allosteric signal in splice variants of Na+/Ca2+ exchange (NCX) proteins." Biochemical Journal 465, no. 3 (January 22, 2015): 489–501. http://dx.doi.org/10.1042/bj20141036.

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Ca2+ binding to CBD1 (calcium-binding domain 1) and CBD2 regulates Na+/Ca2+ exchangers (NCX). In the present study, we demonstrate that Ca2+ binding rigidifies the main chain of CBD2, but not of CBD1, in a splice variant-dependent manner. The dynamic differences account for variant-dependent responses to Ca2+.
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Garrett, Teresa L., Christine M. Rapp, Robert D. Grubbs, John J. Schlager, and James B. Lucot. "A murine model for sarin exposure using the carboxylesterase inhibitor CBDP." NeuroToxicology 31, no. 5 (September 2010): 502–8. http://dx.doi.org/10.1016/j.neuro.2010.05.007.

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Dissertations / Theses on the topic "CBDP"

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Joshi, Kaushal V. "Novel Neuroprotectants for Sarin plus CBDP induced convulsions." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1253321185.

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Henley, Benjamin. "Characterising the anti-convulsant effects of CBD and CBDV on layer II of the medial entorhinal cortex of rat and human brain tissue in vitro." Thesis, Aston University, 2018. http://publications.aston.ac.uk/37675/.

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Epilepsy is a common and serious neurological disorder, which manifests in seizures, and has an incidence of approximately 1% of the world population. In developed nations, most instances are relatively well controlled through the use of anti-epileptic drugs (AEDs). For around a third of cases, AEDs are ineffective, resulting in poorly maintained seizures otherwise known as refractory, or drug-resistant epilepsy (DRE). Currently, treatment of DRE often requires neurosurgery to be performed to resect seizure generating foci. Historically, such treatment was used as a last resort due to the invasive and higher risk nature of neurosurgery. More recently, however, surgical intervention has been performed much earlier in order to achieve better long-term patient outcomes. Notwithstanding this, DRE presents a major and as of yet, unmet clinical need for new and effective antiepileptic drugs to be found. In vitro and in vivo electrophysiological methods have been used investigate epilepsy for many years. Neuronal network oscillations and single cell patching recordings between physiological and pathophysiological samples provide a basis to compare alterations between normal and epileptic brain tissue. In terms of electrophysiological approaches, the hippocampus and entorhinal cortex (EC) are two of the most commonly studied areas of the brain, especially in relation to temporal lobe epilepsy (TLE). Plant derived cannabinoids – phytocannabinoids – have been proposed as effective AEDs for DRE cases. In particular the non-psychoactive phytocannabinoids cannabidiol (CBD) and cannabidivarin (CBDV), with recent clinical trials supporting this claim. The present study is an investigation into whether CBD and CBDV are suitable and effective AEDs, and to identify their mechanism(s) of action. Electrophysiological recordings of medial entorhinal cortex (mEC) layer II principal cells have been studied due to their relative importance and participation in TLE. Alterations in oscillatory rhythms and single cell responses were compared between RISE afflicted epileptic rats (SE rats) and wild type, age matched controls (AMC). Experiments on human tissue resected from children with TLE were also performed, concurrent with the rodent experiments. Key findings from this project show CBD(V) suppressant effects on induced gamma oscillations, in an age- and disease-dependent manner in rat tissue, suggesting damping of neuronal network excitability. Further to this, CBD induces increased GABA inhibition onto rat medial entorhinal principal cells as evidenced by increases in mean median decay times and inhibitory charge transfer across the postsynaptic membrane, while CBDV did not show this effect. The effects of CBD were effectively blocked by both GABAAR and NMDAR antagonists, suggesting interaction with both of these receptors to exert the response. CBD also showed additive effect to low-dose benzodiazepine and barbiturate agonists and a ceiling effect at higher doses, suggestive of an allosteric action on the GABAAR. Similar effects were also noted in the human tissue cells, suggestive of an analogous mechanism of action in humans. Hence, we postulate that CBD is acting at both postsynaptic GABAARs, as a positive allosteric modulator (PAM) and, at pre-/postsynaptic NMDARs, either directly or indirectly, to positively influence GABA signalling mechanisms causing an increase in inhibitory activity at postsynaptic principal cells resulting in decreased neuronal excitability.
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Calhoun, McKenzie L. "Medical Marijuana, CBD and THC." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6880.

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Corral, Rego Lía. "Validación del Cuestionario de Sesgos Cognitivos para la Psicosis (CBQp): Relación con sintomatología, insight y neurocognición." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/670511.

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Introducció: Els biaixos cognitius són clau en la formació i manteniment dels deliris en la psicosi. El Cognitive Biases Questionnaire for Psychosis (CBQp) avalua cinc tipus de biaixos cognitius en la psicosi. L'objectiu d'aquest treball es validar la versió espanyola del CBQp, i estudiar la relació d'aquests biaixos cognitius amb la simptomatologia psicòtica, l’insight i la neurocognició. Material i mètode: La versió espanyola autoritzada del CBQp va ser obtinguda segons el procés de traducir-retrotraducció. La mostra va estar composta per 171 subjectes amb diagnòstics de psicosis. Una anàlisi factorial confirmatòria (AFC) va testar tres models alternatius del constructe. Es van dur a terme comparacions entre pacients amb psicosis i un grup control (N = 30) en relació a les subescales del CBQp. L'associació entre els biaixos del CBQp, les escales d’insight clínic (SUMD) i cognitiu (BCIS), les avaluacions de la simptomatologia psicòtica (PANSS i PDI) i la bateria neurocognitiva MATRICS va ser estudiada mitjançant correlació, diferència de mitjanes i regressions lineals. Resultats: En l’AFC, el CFI va mostrar valors entre 0.94 i 0.95 per als models de 1, 2 i 5 factors, amb valors de RMSEA de 0.031 i 0.029. La fiabilitat del CBQp va ser de 0.87. Els subjectes amb psicosis van puntuar significativament més alt en tots els biaixos cognitius, a excepció de Catastrofisme i Salt a conclusions, en comparació amb el grup control. Es van obtenir associacions entre els biaixos cognitius i les escales d'auto-certesa i insight cognitiu de la BCIS, les escales de malestar, preocupació, convicció i total del PDI, així com amb la simptomatologia positiva avaluada mitjançant la PANSS. El CBQp es va relacionar amb el rendiment cognitiu general avaluat mitjançant la MATRICS, més concretament, amb Velocitat de processament, Solució de problemes i Cognició social. Conclusions: La versió espanyola del CBQp ha mostrat una adequada fiabilitat i validesa. Un model d'1 factor podria ser més adequat per a explicar el constructe de l'escala, suggerint que el CBQp avalua un biaix de pensament general. Els biaixos avaluats pel CBQp implicarian major presència de deliris, malestar, convicció i preocupació respecte a aquests, major simptomatologia positiva, així com un pitjor insight cognitiu i un pitjor rendiment neurocognitiu general.
Introducción: Los sesgos cognitivos son clave en la formación y mantenimiento de los delirios en la psicosis. El Cognitive Biases Questionnaire for Psychosis (CBQp) es un cuestionario que evalúa cinco tipos de sesgos cognitivos en la psicosis. El objetivo de este trabajo es validar la versión española del CBQp, y estudiar la relación de dichos sesgos con la sintomatología psicótica, el insight y la neurocognición. Material y método: La versión española autorizada del CBQp fue obtenida mediante traducción-retrotraducción. La muestra estuvo compuesta por 171 sujetos con diagnósticos de psicosis. Un análisis factorial confirmatorio (AFC) testó tres modelos alternativos del constructo. Se llevaron a cabo comparaciones entre pacientes con psicosis y un grupo control (N = 30) en relación a las subescalas del CBQp. La asociación entre los sesgos del CBQp, el insight clínico (SUMD) y cognitivo (BCIS), la sintomatología psicótica (PANSS y PDI) y la batería neurocognitiva MATRICS fue estudiada mediante correlación, diferencia de medias y regresiones lineales. Resultados: En el AFC, el CFI mostró valores entre 0.94 y 0.95 para los modelos de 1, 2 y 5 factores, con valores de RMSEA de 0.031 y 0.029. La fiabilidad del CBQp fue de 0.87. Los sujetos con psicosis puntuaron significativamente más alto en todos los sesgos cognitivos, a excepción de Catastrofismo y Salto a conclusiones, en comparación con el grupo control. Se obtuvieron asociaciones entre los sesgos cognitivos y las escalas de auto-certeza e insight cognitivo de la BCIS, las escalas de malestar, preocupación, convicción y total del PDI, así como con la sintomatología positiva evaluada mediante la PANSS. El CBQp se relacionó con el rendimiento cognitivo general evaluado mediante la MATRICS, y más concretamente con Velocidad de procesamiento, Solución de problemas y Cognición social. Conclusiones: La versión española del CBQp ha mostrado una adecuada fiabilidad y validez. Un modelo de 1 factor podría ser más adecuado para explicar el constructo de la escala, sugiriendo que el CBQp evalúa un sesgo de pensamiento general. Los sesgos evaluados por el CBQp implicarían mayor presencia de delirios, malestar, convicción y preocupación respecto a éstos, mayor sintomatología positiva, así como un peor insight cognitivo y peor rendimiento neurocognitivo general.
Introduction: Cognitive biases are key factors in the development and maintenance of delusions in psychosis. The Cognitive Biases Questionnaire for Psychosis (CBQp) evaluates five types of cognitive biases that are relevant in psychosis. The aim of this study is to validate the Spanish version of the CBQp, and to study the relationship between these biases and psychotic symptoms, insight and neurocognition. Materials and methods: The Spanish authorized version of the CBQp was obtained by a translation and back-translation procedure. A sample of 171 patients with different diagnoses of psychosis was included. A confirmatory factorial analysis (CFA) tested three different models of the construct. Comparisons of CBQp scales were analysed between patients with psychosis and a control group (N = 30). Associations between the CBQp biases, clinical and cognitive insight (SUMD and BCIS), symptoms (PANSS and PDI) and neurocognition (MATRICS), were studied by correlation and means differences and linear regressions. Results: CFA showed CFI values of 0.94 and 0.95 for the models with 1, 2 and 5 factors, with RMSEA values of 0.031 and 0.029. The reliability of the CBQp was 0.87. When compared with the group of healthy subjects, patients with psychosis scored significantly higher in all cognitive biases, except in Catastrophising (Cat) and Jumping to conclusions (JTC). Associations between cognitive biases and the self-certainty and the total cognitive insight scale of the BCIS were found. In the same way, associations between conviction, distress, preoccupation and total scales of the PDI and cognitive biases were found. The CBQp was also related with positive symptoms evaluated with the PANSS, and with general cognitive performance, specifically with Processing speed, Problem solving and Social cognition. Conclusions: The Spanish version of the CBQp shows high reliability and adequate internal consistency. A one-factor model might be more appropriate for explaining the construct of the scale, suggesting that the CBQp evaluates a general thinking bias rather than different cognitive errors. Cognitive biases involved a greater frequency of delusions, distress, conviction, and preoccupation, and more positive symptoms, as well as worse cognitive insight and worse global neurocognitive performance.
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Jacobsson, Hampus. "Kalibrering och tillämpning utav CBD-modellen." Thesis, Umeå universitet, Institutionen för matematik och matematisk statistik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58002.

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Det stora behovet av att kunna prognostisera och beskriva framtida dödligheter på ett bra sätt och svårigheten i detta har lett till att många olika modeller tagits fram. En av dessa modeller är den s.k. CBD modellen. I detta arbete så har denna kalibrerats efter svensk dödlighetsdata och dess lämplighet att användas har undersökts. Inga större problem med modellen fanns, förutom att den inte var så lämplig för de allra äldsta individerna (över 95 år). Modellen jämfördes med SCB:s framtidsprognos, en jämförelse som inte gav så mycket men som antydde att dödlighet av de yngre av 65-95 åringarna skulle gå snabbare enligt CBD modellen än vad SCB förutspått, motsatsen verkade inträffa för de högre åldrarna. De framtida dödligheter som tagits fram med CBD modellen användes sedan för att räkna ut nuvärde på en försäkrings framtida utbetalningar. Övre gränser för dessa utbetalningar räknades ut med konfidensintervall, men även enligt standardmetod enligt Solvens 2. Resultatet visade att den övre gränsen framtagen m.h.a. konfidensgräns låg högre upp än då motsvarande gräns räknats ut enligt Solvens 2 standardmetoden.
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Delvecchio, Manuela. "Mécanisme de régulation de l'acétyltransférase p300/CBP." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00631344.

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Le p300/CBP acétyltransférase est un co-activateur transcriptionnel très important qui est impliqué dans la régulation d'un grand nombre de processus biologiques, comme la transcription d'ADN, le développement et l'immunité innée. Jusqu'à présent, le rôle de p300/CBP dans la régulation de l'expression des gènes a été largement étudiée, mais les mécanismes qui régulent son activité enzymatique sont encore peu connus. Des études ont montré que le dysfonctionnement de p300/CBP est associé à plusieurs formes de cancer et de maladies neurodégénératives. Dés lors, chaque progrès concernant les mécanismes de régulation de p300/CBP est devenu primordial pour le développement de nouvelles thérapies. Le 'noyau' de p300/CBP contient deux domaines pour la reconnaissance des modifications post-traductionnelles (MPTs), un bromodomaine et un PHD finger (le module BP), adjacent à un domaine HAT (ou domaine histone acétyltransférase). Plusieurs enzymes, modifiant la chromatine, contiennent des domaines de reconnaissance des MPTs. Fréquemment des groupements particuliers de ces domaines sont très conservés et liés, au sein de la même protéine ou du même complexe protéique, suggérant qu'ils réalisent des fonctions coordonnées. Ces domaines adjacents peuvent agir en concertation dans la reconnaissance simultanée de différents MPTs ou peuvent exercer des fonctions différentes de celles qui sont effectuées par ces deux domaines particuliers, tels que les fonctions de régulation enzymatique. Plusieurs études suggèrent que les cycles acétylation/désacétylation dans la boucle d'auto-inhibition, à l'intérieur du domaine HAT, jouent un rôle important dans la régulation de l'activité enzymatique de p300/CBP. La proximité du module BP et du domaine HAT suggère que la spécificité de liaison, appartenant au module BP, peut être intrinsèquement liée à la régulation de l'activité du domaine HAT. L'objectif de ma thèse est de déterminer le rôle du module BP dans la régulation de l'activité du domaine HAT. Je propose que le module BP soit impliqué dans la régulation de p300/CBP de deux façons. La première consiste à établir un lien avec le domaine HAT qui stabilise la conformation auto-inhibée de l'enzyme. La deuxième exige que le module BP joue un rôle dans le choix des substrats de p300/CBP. J'ai été en mesure de montrer que BP peut se lier au domaine HAT et à la chromatine modifiée et qu'il peut reconnaître les modifications effectuées par p300/CBP lui-même. Les données obtenues indiquent que le module BP peut être impliqué dans la régulation de l'activité de p300/CBP et dans son ciblage à la chromatine.
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Klein, Fabrice. "Etudes structurales des interactions CBP-récepteurs nucléaires." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. http://www.theses.fr/2003STR13241.

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Les récepteurs nucléaires (NRs) forment une famille de facteurs de transcription dont l'activité est contrôlée par la fixation de ligands. La liaison à un ligand agoniste permet le recrutement de coactivateurs transcriptionnels, comme les p300/CREB‑Binding­Protein (p300/CBP) et les p160/Steroid‑Receptor­‑Coactivator (p160/SRC). Ces protéines possèdent plusieurs motifs LxxLL (L = Leucine ; X = n'importe quel acide aminé), responsables de l'interaction aux NRs. Nous avons caractérisé le domaine de CBP interagissant aux LBDs et co‑cristallisé un complexe de l'extrémité Nterminale de CBP (Nter‑CBP) et du LBD du Peroxisome Proliferator‑Activated Receptor gamma (lbd‑PPARg). La mauvaise qualité des cristaux de Nter‑CBP/lbd‑PPARg n'a pas permis de déterminer la structure du complexe. L'étude de Nter‑CBP par résonance magnétique nucléaire (RMN) montre que ce fragment isolé est peu structuré. Son interaction aux LBDs de trois NRs - PPARg, Retinoid X Receptor alpha (RXRa) et Estrogen Related Receptor gamma (ERRg) - a été étudiée par RMN. En raison d'une forte atténuation du signal des résidus impliqués dans l'interaction aux LBDs, la structure du fragment de mCBP en complexe à un LBD n'a pu être résolue, mais la zone d'interaction a été cartographiée : les résidus de CBP impliqués dans l'interaction représentent deux fragments discontinus, délimités par les acides aminés (31 à 38) et (61 à 80), la zone (61 à 80) contenant un LxxLL. L'interaction de fragments de CBP ou de SRCs aux LBDs de PPARg et RXRa a été étudiée de façon comparative par résonance plasmonique de surface (SPR) et par électrophorèse en conditions natives (N‑PAGE). Les résultats montrent l'existence d'interactions préférentielles entre RXRa et les SRCs, et entre PPARg et CBP. Les conclusions de nos travaux suggèrent que CBP puisse être recruté directement par l'hétérodimère PPARg/RXRa, ce qui pourrait jouer un rôle dans la permissivité de cet hétérodimère
Nuclear receptors form a large family of transcription factors, whose activities are often controled by the fixation of small ligands. Binding to an agonist ligand allows the recruitment of transcriptional coactivators, like the p300/CREB‑Binding­Protein (p300/CBP) or the p160/Steroid‑Receptor­‑Coactivator (p160/SRC). Those coactivators possess several LxxLL motifs (L = Leucine ; X = any aminoacid), mainly responsible for the interaction with NRs. We characterized the aminoterminal (Nter) domain of CBP responsible for the interaction with NR Ligand Binding Domains (LBDs) and cocrystallized it together with the Peroxisome Proliferator‑Activated Receptor gamma LBD (lbd‑PPARg). The poor diffraction properties of the crystals did not allow us to solve the structure of this (Nter-CBP/lbd-PPARg) complex. Nuclear Magnetic Resonance (NMR) experiments demonstrate that Nter-CBP is poorly structured on its own. Its interaction with the LBDs of 3 different NRs - PPARg, Retinoid X Receptor alpha (RXRa) and Estrogen Related Receptor gamma (ERRg) – was studied by NMR. The structure of CBP in complex with any of these LBDs could not be solved, because of a strong signal attenuation of the residues implied in the interaction. Nevertheless, the aminoacids of CBP that interact with those 3 NRs could be mapped by this technique : they correspond to 2 discontinuous zones, delimited by the aminoacids (31 to 38) and (61 to 80), the latter containing the LxxLL motif. We also studied the interaction between CBP or SRCs fragments with lbd-PPARg and lbd-RXRa, in a comparative manner, by surface plasmon resonance and native electrophoresis. Our results show that CBP interacts preferentially with PPARg, whereas SRCs show a better affinity towards RXRa. We suggest that CBP might be directly recruited by PPARg/RXRa, which could play a role in the permissivity of this heterodimer
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Fujiki, Kazuhiko. "A study on CBD land value variations." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27261.

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This thesis examines CBD (Central Business District) land value variations. The objectives of this study are (1) to compare monocentric and nonmonocentric models and (2) to analyze the determinants of CBD land value variations. Transactions of vacant land from 1975 to 1987 in Central Ward (Chuo Ku), Tokyo, comprise the data base for this study. A monocentric model and nonmonocentric model are compared using a negative exponential function and trend surface analysis (based on a double power series of location coordinates). For the comparison, three-dimensional pictures and contour maps are utilized as well as statistics of goodness-of-fit and predictive powers. To analyze determinants of CBD land value variations, we employ a hedonic-price approach. Trend surface analysis is superior to the monocentric model in terms of goodness-of-fit and predictive powers. However, centrality is still an important determinant. Proximity to subway or railway stations, or to the Ginza shopping area, are also important factors. Other influential determinants include time of sale, lot shape, corner location, road width, and floor area ratio.
Business, Sauder School of
Graduate
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Meredith, David. "Computing pitch names in tonal music : a comparative analysis of pitch spelling algorithms." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:fa543bd6-cbdc-4206-a6f6-518f54c8c49a.

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A pitch spelling algorithm predicts the pitch names (e.g., C♯4, B♭5 etc.) of the notes in a passage of tonal music, when given the onset-time, MIDI note number and possibly the duration and voice of each note. A new algorithm, called ps13, was compared with the algorithms of Longuet-Higgins, Cambouropoulos, Temperley and Chew and Chen by running various versions of these algorithms on a ‘clean’, score-derived test corpus, C, containing 195972 notes, equally divided between eight classical and baroque composers. The standard deviation of the accuracies achieved by each algorithm over the eight composers was used to measure style dependence (SD). The best versions of the algorithms were tested for robustness to temporal deviations by running them on a ‘noisy’ version of the test corpus, denoted by C'. A version of ps13 called PS13s1 was the most accurate of the algorithms tested, achieving note accuracies of 99.44% (SD = 0.45) on C and 99.41% (SD = 0.50) on C'. A real-time version of PS13s1 also out-performed the other real-time algorithms tested, achieving note accuracies of 99.19% (SD = 0.51) on C and 99.16% (SD = 0.53) on C'. PS13s1 was also as fast and easy to implement as any of the other algorithms. New, optimised versions of Chew and Chen’s algorithm were the least dependent on style over C. The most accurate of these achieved note accuracies of 99.15% (SD = 0.42) on C and 99.12% (SD = 0.47) on C'. It was proved that replacing the spiral array in Chew and Chen’s algorithm with the line of fifths never changes its output. A new, optimised version of Cambouropoulos’s algorithm made 8% fewer errors over C than the most accurate of the versions described by Cambouropoulos himself. This algorithm achieved note accuracies of 99.15% (SD = 0.47) on C and 99.07% (SD = 0.53) on C'. A new implementation of the most accurate of the versions described by Cambouropoulos achieved note accuracies of 99.07% (SD = 0.46) on C and 99.13% (SD = 0.39) on C', making it the least dependent on style over C'. However, Cambouropoulos’s algorithms were among the slowest of those tested. When Temperley and Sleator’s harmony and meter programs were used for pitch spelling, they were more affected by temporal deviations and tempo changes than any of the other algorithms tested. When enharmonic changes were ignored and the music was at a natural tempo, these programs achieved note accuracies of 99.27% (SD = 1.30) on C and 97.43% (SD = 1.69) on C'. A new implementation, called TPROne, of just the first preference rule in Temperley’s theory achieved note accuracies of 99.06% (SD = 0.63) on C and 99.16% (SD = 0.52) on C'. TPROne’s performance was independent of tempo and less dependent on style than that of the harmony and meter programs. Of the several versions of Longuet-Higgins’s algorithm tested, the best was the original one, implemented in his music.p program. This algorithm achieved note accuracies of 98.21% (SD = 1.79) on C and 98.25% (SD = 1.71) on C', but only when the data was processed a voice at a time. None of the attempts to take voice-leading into account in the algorithms considered in this study resulted in an increase in note accuracy and the most accurate algorithm, PS13s1, ignores voice-leading altogether. The line of fifths is used in most of the algorithms tested, including PS13s1. However, the superior accuracy achieved by PS13s1 suggests that pitch spelling accuracy can be optimised by modelling the local key as a pitch class frequency distribution instead of a point on the line of fifths, and by keeping pitch names close to the local tonic(s) on the line of fifths rather than close on the line of fifths to the pitch names of neighbouring notes.
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Shabala, Alexander. "Mathematical modelling of oncolytic virotherapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:cca2c9bc-cbd4-4651-9b59-8a4dea7245d1.

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This thesis is concerned with mathematical modelling of oncolytic virotherapy: the use of genetically modified viruses to selectively spread, replicate and destroy cancerous cells in solid tumours. Traditional spatially-dependent modelling approaches have previously assumed that virus spread is due to viral diffusion in solid tumours, and also neglect the time delay introduced by the lytic cycle for viral replication within host cells. A deterministic, age-structured reaction-diffusion model is developed for the spatially-dependent interactions of uninfected cells, infected cells and virus particles, with the spread of virus particles facilitated by infected cell motility and delay. Evidence of travelling wave behaviour is shown, and an asymptotic approximation for the wave speed is derived as a function of key parameters. Next, the same physical assumptions as in the continuum model are used to develop an equivalent discrete, probabilistic model for that is valid in the limit of low particle concentrations. This mesoscopic, compartment-based model is then validated against known test cases, and it is shown that the localised nature of infected cell bursts leads to inconsistencies between the discrete and continuum models. The qualitative behaviour of this stochastic model is then analysed for a range of key experimentally-controllable parameters. Two-dimensional simulations of in vivo and in vitro therapies are then analysed to determine the effects of virus burst size, length of lytic cycle, infected cell motility, and initial viral distribution on the wave speed, consistency of results and overall success of therapy. Finally, the experimental difficulty of measuring the effective motility of cells is addressed by considering effective medium approximations of diffusion through heterogeneous tumours. Considering an idealised tumour consisting of periodic obstacles in free space, a two-scale homogenisation technique is used to show the effects of obstacle shape on the effective diffusivity. A novel method for calculating the effective continuum behaviour of random walks on lattices is then developed for the limiting case where microscopic interactions are discrete.
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Books on the topic "CBDP"

1

Sifelani, Tsiko, and Community Biodiversity Development and Conservation--Africa, eds. CBDC Africa experiences. Harare: CBDC Africa Network, 2009.

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Communities, United States Environmental Protection Agency Office of Sustainable Ecosystems and. Community-based environmental protection(CBEP): Characterization of EPA Regional CBEP Activities. Chicago, Ill: U.S. Environmental Protection Agency, 1999.

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Phillips, Joseph. CBAP Certified Business Analysis Professional. New York: McGraw-Hill, 2009.

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U.S. Environmental Protection Agency Office of Sustainable Ecosystems and Communities. Community-based environmental protection(CBEP): Accomplishments and value-added of EPA CBEP projects. Fairfax, VA: ICF Incorporated, 1999.

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Schaefer, Dirk, ed. Cloud-Based Design and Manufacturing (CBDM). Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07398-9.

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Harrison, Donald D. CBP x-ray workbook. [S.l.]: Donald D. Harrison, 1989.

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U.S. Customs and Border Protection. CBP inspector's field manual. Washington, D.C: American Immigration Lawyers Association, 2008.

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1959-, Wagner Terri A., and ebrary Inc, eds. CBAP / CCBA: Certified business analysis study guide. Indianapolis, Ind: Wiley Pub., 2011.

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Comentários ao Código brasileiro disciplinar do futebol-CBDF. Rio de Janeiro: Forense, 1997.

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Harrison, Deed E. CBP structural rehabilitation of the lumbar spine. [Evanston, Wyo.]: Harrison CBP Seminars, 2008.

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Book chapters on the topic "CBDP"

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Peters, Nils, Martin Dichgans, Sankar Surendran, Josep M. Argilés, Francisco J. López-Soriano, Sílvia Busquets, Klaus Dittmann, et al. "CBD." In Encyclopedia of Molecular Mechanisms of Disease, 294. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7302.

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ten Have, Henk, and Maria do Céu Patrão Neves. "CBD." In Dictionary of Global Bioethics, 39. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54161-3_18.

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Li, Qiang. "CBDs Development Model." In Research Series on the Chinese Dream and China’s Development Path, 259–89. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-9451-5_9.

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Shelvock, Matthew T. "Case Studies in CBMP." In Cloud-Based Music Production, 149–56. New York : Routledge, 2020. | Series: Perspectives on music production: Focal Press, 2020. http://dx.doi.org/10.4324/9781351137102-6.

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Turnell, Andrew S. "CBP/p300 Coactivators." In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_899-2.

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Turnell, Andrew S. "CBP/p300 Coactivators." In Encyclopedia of Cancer, 833–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46875-3_899.

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Roychoudhury, Priodarshi, Ning Nan Wang, and Samer N. Narouze. "Phytocannabinoids: Cannabidiol (CBD)." In Cannabinoids and Pain, 79–86. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69186-8_11.

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Wu, Dazhong, David W. Rosen, and Dirk Schaefer. "Cloud-Based Design and Manufacturing: Status and Promise." In Cloud-Based Design and Manufacturing (CBDM), 1–24. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07398-9_1.

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Red, Edward, David French, Ammon Hepworth, Greg Jensen, and Brett Stone. "Multi-User Computer-Aided Design and Engineering Software Applications." In Cloud-Based Design and Manufacturing (CBDM), 25–62. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07398-9_2.

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Zhang, Zhinan, Xiang Li, Yonghong Liu, and Youbai Xie. "Distributed Resource Environment: A Cloud-Based Design Knowledge Service Paradigm." In Cloud-Based Design and Manufacturing (CBDM), 63–87. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-07398-9_3.

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Conference papers on the topic "CBDP"

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Silva, Renan F. F. da, Yulle G. F. Borges, and Rafael C. S. Schouery. "Heurísticas para o Problema do Empacotamento Colorido." In Encontro de Teoria da Computação. Sociedade Brasileira de Computação - SBC, 2021. http://dx.doi.org/10.5753/etc.2021.16374.

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O Problema do Empacotamento Colorido (CBPP) é uma generalização do Problema do Empacotamento (BPP) onde, dado um conjunto de itens com um tamanho e uma cor, devemos empacotar os itens em recipientes de capacidade limitada, minimizando a quantidade de recipientes utilizados e satisfazendo a restrição que dois itens de mesma cor não podem ser empacotados lado a lado em um mesmo recipiente. Neste artigo, propomos a adaptação de heurísticas do BPP para o CBPP acompanhado de algumas heurísticas novas para o problema. Propomos também uma heurística para o CBPP baseada em Variable Neighborhood Search. Os resultados indicam que a nossa abordagem é capaz de encontrar boas soluções para instâncias grandes do problema.
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Anh Vang, Tran, Xianmin Zhang, and Benliang Zhu. "Design and Optimization of a Highly Sensitive and Linearity Piezoresistive Pressure Sensor Based on a Combination of Cross Beam-Peninsula-Membrane Structure." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70485.

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The sensitivity and linearity trade-off problem has become the hotly important issues in designing the piezoresistive pressure sensors. To solve these trade-off problems, this paper presents the design, optimization, fabrication, and experiment of a novel piezoresistive pressure sensor for micro pressure measurement based on a combined cross beam - membrane and peninsula (CBMP) structure diaphragm. Through using finite element method (FEM), the proposed sensor performances as well as comparisons with other sensor structures are simulated and analyzed. Compared with the cross beam-membrane (CBM) structure, the sensitivity of CBMP structure sensor is increased about 38.7 % and nonlinearity error is reduced nearly 8%. In comparison with the peninsula structure, the maximum non-linearity error of CBMP sensor is decreased about 40% and the maximum deflection is extremely reduced 73%. Besides, the proposed sensor fabrication is performed on the n-type single crystal silicon wafer. The experimental results of the fabricated sensor with CBMP membrane has a high sensitivity of 23.4 mV/kPa and a low non-linearity of −0.53% FSS in the pressure range 0–10 kPa at the room temperature. According to the excellent performance, the sensor can be applied to measure micro-pressure lower than 10 kPa.
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Wu, Dazhong, J. Lane Thames, David W. Rosen, and Dirk Schaefer. "Towards a Cloud-Based Design and Manufacturing Paradigm: Looking Backward, Looking Forward." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70780.

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The rise of cloud computing is radically changing the way enterprises manage their information technology (IT) assets. Considering the benefits of cloud computing to the information technology sector, we present a review of current research initiatives and applications of the cloud computing paradigm related to product design and manufacturing. In particular, we focus on exploring the potential of utilizing cloud computing for selected aspects of collaborative design, distributed manufacturing, collective innovation, data mining, semantic web technology, and virtualization. In addition, we propose to expand the paradigm of cloud computing to the field of computer-aided design and manufacturing and propose a new concept of cloud-based design and manufacturing (CBDM). Specifically, we (1) propose a comprehensive definition of CBDM; (2) discuss its key characteristics; (3) relate current research in design and manufacture to CBDM; and (4) identify key research issues and future trends.
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"CBD 2019 Reviewers." In 2019 Seventh International Conference on Advanced Cloud and Big Data (CBD). IEEE, 2019. http://dx.doi.org/10.1109/cbd.2019.00009.

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"CBD 2020 Reviewers." In 2020 Eighth International Conference on Advanced Cloud and Big Data (CBD). IEEE, 2020. http://dx.doi.org/10.1109/cbd51900.2020.00009.

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Choong, Yeow Wei, Lisa Di Jorio, Anne Laurent, Dominique Laurent, and Maguelonne Teisseire. "CBGP: Classification Based on Gradual Patterns." In 2009 International Conference of Soft Computing and Pattern Recognition. IEEE, 2009. http://dx.doi.org/10.1109/socpar.2009.15.

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Tsai, Wei-Tek, Zihao Zhao, Chi Zhang, Lian Yu, and Enyan Deng. "A Multi-Chain Model for CBDC." In 2018 5th International Conference on Dependable Systems and Their Applications (DSA). IEEE, 2018. http://dx.doi.org/10.1109/dsa.2018.00016.

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"COMPONENT-BASED SOFTWARE DEVELOPMENT ENVIRONMENT (CBDE)." In 6th International Conference on Enterprise Information Systems. SciTePress - Science and and Technology Publications, 2004. http://dx.doi.org/10.5220/0002638303380343.

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Jing Guo, Ming Tien, and Jeffrey M Catchmark. "Biosynthesis of cellulose binding domains (CBDs)." In 2009 Reno, Nevada, June 21 - June 24, 2009. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2009. http://dx.doi.org/10.13031/2013.27275.

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Ginsburg, D. "ATM support for the SMDS/CBDS." In IEE Colloquium on Practical Experience with SMDS (Switched Multi-Megabit Data Service). IEE, 1995. http://dx.doi.org/10.1049/ic:19950995.

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Reports on the topic "CBDP"

1

Slezak, T., and M. Wolinsky. FY02 CBNP Annual Report Input: Bioinformatics Support for CBNP Research and Deployments. Office of Scientific and Technical Information (OSTI), October 2002. http://dx.doi.org/10.2172/15002105.

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MacDonald, R. J., and D. A. Payne. Changing mining methods at CBDC. Natural Resources Canada/CMSS/Information Management, 1993. http://dx.doi.org/10.4095/328669.

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Nayfack, Nicholas, and Robert W. MacDougall. Chemical Biological Defense (CBD) Simulations. Fort Belvoir, VA: Defense Technical Information Center, July 1996. http://dx.doi.org/10.21236/ada396828.

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Smith, F., K. Brown, G. Flach, and S. Sarkar. CBP PHASE I CODE INTEGRATION. Office of Scientific and Technical Information (OSTI), September 2011. http://dx.doi.org/10.2172/1026836.

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Banks, G. N., J. K. L. Wong, and H. Whaley. Combustion evaluation of CBDC Phalen/Lingan coal middlings. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1991. http://dx.doi.org/10.4095/304502.

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Banks, G. N., J. K. Wong, and H. Whaley. Pilotscale combustion trials with CBDC metallurgical grade coal. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1985. http://dx.doi.org/10.4095/302575.

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Hunag, Haojie. CBP and p27KIP1 in Prostate Carcinogenesis. Fort Belvoir, VA: Defense Technical Information Center, February 2008. http://dx.doi.org/10.21236/ada482547.

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Smith, F., G. Flach, and K. BROWN. CBP TOOLBOX VERSION 2.0: CODE INTEGRATION ENHANCEMENTS. Office of Scientific and Technical Information (OSTI), June 2013. http://dx.doi.org/10.2172/1090364.

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Wiley, Jenny L., Camille K. Gourdet, and Brian F. Thomas. Cannabidiol: Science, Marketing, and Legal Perspectives. RTI Press, April 2020. http://dx.doi.org/10.3768/rtipress.2020.op.0065.2004.

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Recent loosening of legal restrictions on cannabis and its chemical constituents, including phytocannabinoids such as Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), has led to rapid proliferation and wide availability of products containing CBD. Although using pure CBD does not result in THC-like intoxication, it is not risk-free. In this review, we examine CBD from scientific, marketing, and regulatory perspectives. Specifically, we evaluate the evidence used to support statements concerning CBD’s real and putative medical effects and discuss misleading information that has been used in marketing approaches. Also, we explore the current legal landscape surrounding CBD. We conclude that further research is necessary to clarify legitimate therapeutic effects of CBD. Federal regulation is also necessary to assure quality, safety, and efficacy of CBD products. Until new regulations are enacted to ensure purity and label accuracy, consumers should balance any perceived benefits of CBD use against potential risks associated with using products of unknown quality.
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Shriver, Craig D., and Lee Bronfman. Comprehensive Reproductive System Care Program - Clinical Breast Care Project (CRSCP-CBCP). Fort Belvoir, VA: Defense Technical Information Center, January 2013. http://dx.doi.org/10.21236/ada612767.

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