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Academic literature on the topic 'CBPP'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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Journal articles on the topic "CBPP"

1

DESA, M. N., S. D. SEKARAN, J. VADIVELU, and N. PARASAKTHI. "Distribution of CBP genes in Streptococcus pneumoniae isolates in relation to vaccine types, penicillin susceptibility and clinical site." Epidemiology and Infection 136, no. 7 (August 3, 2007): 940–42. http://dx.doi.org/10.1017/s0950268807009363.

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SUMMARYCholine-binding proteins (CBP) have been associated with the pathogenesis of Streptococcus pneumoniae. We screened, using PCR, for the presence of genes (cbpA, D, E, G) encoding these proteins in 34 isolates of pneumococci of known serotypes and penicillin susceptibility from invasive and non-invasive disease. All isolates harboured cbpD and cbpE whereas cbpA and cbpG were found in 47% and 59% respectively; the latter were more frequent in vaccine-associated types and together accounted for 77% of these isolates. No association was observed with penicillin susceptibility but 85% of non-invasive isolates were positive for these genes.

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Ramathudi-Dunbar, Lorato, Emmanuel Awosanya, Sanne Bodjo Charles, Ethel Chitsungo, Cisse Rahamatou Moustapha Boukary, Nick Nwankpa, Hassen Gelaw, et al. "Development and Evaluation of Monoclonal Antibodies against CBPP Antigen with the End Goal of Developing an ELISA Kit." Veterinary Medicine International 2024 (May 7, 2024): 1–10. http://dx.doi.org/10.1155/2024/6901355.

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Contagious bovine pleuropneumonia (CBPP) is an infectious and contagious bacterial respiratory disease that affects cattle with significant economic losses to the African animal industry. The use of ELISA kits based on monoclonal antibodies (mAbs) will aid in quick and precise diagnosis of CBPP, contributing to disease control and prevention in cattle. Thus, this research aims to develop and evaluate monoclonal antibodies against CBPP (T1/44) antigen for use in ELISA kits for CBPP diagnosis. Hybridoma technology was used to develop monoclonal antibodies that recognize and bind to the CBPP (T1/44) antigen. The antibody-secreting hybridomas were produced after immunizing mice with purified CBPP antigens. The hybridomas were screened for high sensitivity, specificity, and liking to the antigen. The selected mAbs were assessed for sensitivity and specificity against CBPP antigen using different immunoassays, dot-blot, ELISA, and mouse mAb isotyping. The monoclonal antibodies were profoundly specific, with a higher hindrance to CBPP antigen (<0.50 OD) while lacking cross-reactivity to other antigens. The monoclonal antibodies could distinguish CBPP antigen at low concentrations, showing their high sensitivity (>80% PI). The isotyped mAbs of intrigued appeared to have a place in the IgG class. These identified monoclonal antibodies can be utilized to develop an ELISA kit for CBPP diagnosis, which would give a fast, precise, and cost-effective strategy for screening and checking CBPP in cattle herds.

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Mosisa, Tekilu, Eyob Hirpa, and Abraham Kebede. "Seroprevalence and risk factors of contagious bovine pleuropneumonia in Horo Guduru Wallagga zone, Western Ethiopia." Veterinarski glasnik 77, no. 2 (2023): 149–63. http://dx.doi.org/10.2298/vetgl221215009m.

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Livestock diseases pose a major threat to animal health and farmer livelihoods in Ethiopia. Contagious bovine pleuropneumonia (CBPP) is a major threat. It is caused by Mycoplasma mycoides subsp. mycoides. This bacterial infection affects cattle and causes pneumonia. To assess the current situation, a study was conducted in Horo Guduru Wallagga, Ethiopia. The main objectives were to determine the seroprevalence of CBPP in cattle and evaluate farmer knowledge, attitudes, and practices related to the disease. Cross-sectional studies were conducted from October 2019 up to June 2020. Blood samples were collected and tested for antibodies against M. mycoides using a cELISA test from cattle (n = 768). Questionnaires were also administered to farmers (n = 20 households) in three districts. The seroprevalence results showed 14.3% of cattle were positive for CBPP antibodies. CBPP seroprevalence was 16.4% in Abe Dongoro, 13.6% in Hababu Guduru, and 10.8% in Guduru. The seroprevalence among the three districts surveyed did not show statistically significant differences. The majority of respondents (77%) were male and the minority (23%) were female. The farmer survey revealed knowledge gaps; only 4.5% of respondents recognized CBPP as a disease causing reduced growth and productivity. In conclusion, this study found a high CBPP seroprevalence, indicating active infection, in the cattle population sampled. Targeted education and disease control efforts are needed to curb the further spread of CBPP. The questionnaire results highlight the need for farmer training on CBPP risks, prevention, and treatment. Ultimately, collaborative strategies are required to safeguard animal health and livelihoods in this region.

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Luebke, Luisa, Philip Gouverneur, Tibor M. Szikszay, Wacław M. Adamczyk, Kerstin Luedtke, and Marcin Grzegorzek. "Objective Measurement of Subjective Pain Perception with Autonomic Body Reactions in Healthy Subjects and Chronic Back Pain Patients: An Experimental Heat Pain Study." Sensors 23, no. 19 (October 3, 2023): 8231. http://dx.doi.org/10.3390/s23198231.

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Multiple attempts to quantify pain objectively using single measures of physiological body responses have been performed in the past, but the variability across participants reduces the usefulness of such methods. Therefore, this study aims to evaluate whether combining multiple autonomic parameters is more appropriate to quantify the perceived pain intensity of healthy subjects (HSs) and chronic back pain patients (CBPPs) during experimental heat pain stimulation. HS and CBPP received different heat pain stimuli adjusted for individual pain tolerance via a CE-certified thermode. Different sensors measured physiological responses. Machine learning models were trained to evaluate performance in distinguishing pain levels and identify key sensors and features for the classification task. The results show that distinguishing between no and severe pain is significantly easier than discriminating lower pain levels. Electrodermal activity is the best marker for distinguishing between low and high pain levels. However, recursive feature elimination showed that an optimal subset of features for all modalities includes characteristics retrieved from several modalities. Moreover, the study’s findings indicate that differences in physiological responses to pain in HS and CBPP remain small.

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5

Neiman, Maja, Carl Hamsten, Jochen M. Schwenk, Göran Bölske, and Anja Persson. "Multiplex Screening of Surface Proteins from Mycoplasma mycoides subsp. mycoides Small Colony for an Antigen Cocktail Enzyme-Linked Immunosorbent Assay." Clinical and Vaccine Immunology 16, no. 11 (September 2, 2009): 1665–74. http://dx.doi.org/10.1128/cvi.00223-09.

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ABSTRACT A recombinant antigen cocktail enzyme-linked immunosorbent assay (ELISA) for diagnosis of contagious bovine pleuropneumonia (CBPP) was developed after careful selection of antigens among one-third of the surface proteome proteins of the infectious agent Mycoplasma mycoides subsp. mycoides small colony (M. mycoides SC). First, a miniaturized and parallelized assay system employing antigen suspension bead array technology was used to screen 97 bovine sera for humoral immune responses toward 61 recombinant surface proteins from M. mycoides SC. Statistical analysis of the data resulted in selection of eight proteins that showed strong serologic responses in CBPP-affected sera and minimal reactivity in negative control sera, with P values of <10−6. Only minor cross-reactivity to hyperimmune sera against other mycoplasmas was observed. When applied in an ELISA, the cocktail of eight recombinant antigens allowed a fivefold signal separation between 24 CBPP-affected and 23 CBPP-free sera from different geographical origins. No false-positive results and only two false-negative results were obtained. In conclusion, the selected recombinant mycoplasma antigens qualified as highly specific markers for CBPP and could be employed in both a suspension bead array platform and a cocktail ELISA setting. This set of proteins and technologies therefore offers a powerful combination to drive and further improve serological assays toward reliable, simple, and cost-effective diagnosis of CBPP.

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Kebede, Wosenyelesh, Rahmeto Abebe, and Jemere Bekele Harito. "Sero-epidemiology of Contagious Bovine Pleuropneumonia in the Bench-Maji Zone, southwest Ethiopia." Ethiopian Veterinary Journal 26, no. 1 (April 29, 2022): 30–48. http://dx.doi.org/10.4314/evj.v26i1.3.

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Contagious bovine pleuropneumonia (CBPP) is a highly contagious respiratory disease in cattle that affects close to 30 countries in sub-Saharan Africa. In Ethiopia, it is one of the major diseases causing reduced cattle productivity and lower performance, particularly in the pastoral areas, and poses a threat to the livestock export market. A cross-sectional study aimed at estimating the seroprevalence and assessing the associated risk factors of CBPP was conducted between December 2018 and May 2019. For this purpose, a pre-tested semi-structured questionnaire survey and a serological analysis of serum samples from 715 cattle were carried out in three districts selected from the Bench-Maji Zone. The sera were tested with a competitive enzyme-linked immunosorbent assay (c-ELISA). Accordingly, a total of 162 (22.7%) cattle were tested seropositive. The seroprevalence was 32.3% in Meanitshasha, 19.2% in South Bench, and 2.8% in the Shey Bench district. The study found that breed, district (agro-ecology), and history of the CBPP outbreak were the risk factors for CBPP seropositivity identified by a generalized linear mixed model. The seroprevalence of CBPP was significantly higher in crossbred cattle (Adjusted Prevalence Ratio (APR) = 4.5; p <0.001), cattle from the Meanitshasha (lowland) district (APR = 13.9; p <0.001), from South Bench (midland) district (APR = 6.9; p = 0.001) and herds with a history of CBPP outbreaks (APR = 1.4; p = 0.009). The seroprevalence found in the present study indicates that CBPP is a common threat to cattle production in the Bench Maji zone. Therefore, all actors involved in the livestock sector should work together to achieve the successful implementation of strategies to control the disease. It is also important to note that a well-coordinated approach should be addressed with an effective vaccination campaign to prevent the further spread of the disease and lower the prevalence of the disease in the area.

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Markus, I. F., J. Adamu, L. Allam, C. N. Kwanashie, M. A. Raji, and B. Mohammed. "Epidemiological and pathological screening of suspected cases of contagious bovine pleuropneumonia in Yola Modern Abattoir, Adamawa State Nigeria." Nigerian Veterinary Journal 42, no. 4 (November 14, 2022): 292–300. http://dx.doi.org/10.4314/nvj.v42i4.5.

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Contagious bovine pleuropneumonia is an important infectious disease of cattle caused by Mycoplasma mycoides subsp. mycoides and a major constraint to cattle production in sub-Saharan Africa. This study was aimed to identify pathological and histopathological lesions identified in cattle tentatively diagnosed with CBPP at Yola Modern Abattoir, Adamawa State. A total of 9,750 cattle were examined at post-mortem for a period of six months, 110 (1.13%) had lesions suggestive of CBPP out of which seventeen (17) were randomly selected and processed for histopathology based on standard laboratory protocols. Based on sex, CBPP lesion was observed more in female 63 (1.06%) than in the male 47 (1.24%). Whereas, CBPP lesions was observed highest in White Fulani breed 68 (1.14%) followed by Cross breeds 23 (91.16%) and Sokoto Gudali 19 (1.74%) and lowest in Red Bororo 10 (1.36%). There was insignificant statistical association (P>0.05) between CBPP lesions and sex and breed of cattle sampled. Age distribution of CBPP lesion was observed higher in cattle between ages of 4-7 years 79 (1.16%), followed by cattle of 1-3 years 28 (1.15%) and least in cattle less than 1 year 3 (0.60%) with significant statistical difference (P<0.05) between the age groups. Histopathology lesions observed include severe congestion of pulmonary blood vessel in all the lung tissues and fibrin exudation into inter-alveolar spaces with almost all the alveoli collapsed. The bronchiolar epithelium was observed to be thickened, hyperplastic and folded, with a considerable quantity of edematous fluid and numerous inflammatory cells seen in the lumen. In conclusion, this study had demonstrated the presence of CBPP lesions in cattle in the study area. Therefore, serological screening of all cattle, stamping out policies and aggressive annual vaccination campaigns are thus recommended in the study area.

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BALENGHIEN, T., K. CHALVET-MONFRAY, D. J. BICOUT, and P. SABATIER. "Modelling and determination of the transmission contact rate for contagious bovine pleuropneumonia." Epidemiology and Infection 133, no. 2 (February 2, 2005): 337–42. http://dx.doi.org/10.1017/s0950268804003498.

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Contagious bovine pleuropneumonia (CBPP) is a cattle respiratory disease that represents one of the major threats to cattle health and production in sub-Saharan Africa. The transmission contact rate of CBPP plays a key role in the spreading dynamics of the disease. We have developed an approach based on the combination of a SEIR model describing the spread of CBPP with the dynamic of seroconversion to determine the transmission contact rate for CBPP. This method has been subsequently applied to serological diagnostic data obtained from an experimental vaccine trial. As a result, we find that the transmission contact rates for subclinical, clinical and chronic infective states are respectively, 0·084/N, 0·45 and 0·14/N per animal per day, where N is the herd population size, and the basic reproductive number corresponding to this trial (N=28) is R0=27.

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Mamo, Yosef, Molalegne Bitew, Tsegaye Teklemariam, Murga Soma, Debebe Gebre, Temesgen Abera, Tefera Benti, and Yosef Deneke. "Contagious Bovine Pleuropneumonia: Seroprevalence and Risk Factors in Gimbo District, Southwest Ethiopia." Veterinary Medicine International 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/5729296.

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Contagious bovine pleuropneumonia (CBPP) is a highly contagious disease of cattle which is one of the great plagues which continues to devastate the cattle herds on which so many people are dependent in Africa. Cross-sectional study was conducted from October 2015 to August 2016 to determine the seroprevalence of CBPP in cattle and associated risk factors in Gimbo district, Southwest Ethiopia. A total of 384 serum samples were collected and tested for the presence of specific antibodies against Mycoplasma mycoides subspecies mycoides small colony (MmmSC), using a competitive enzyme-linked immunosorbent assay (cELISA). Univariable and multivariable logistic regression analysis were performed to determine the association between risk factors and seroprevalence of CBPP. An overall seroprevalence of CBPP was 8.1% (31/384) and it was ranging from 0% to 20% across different Peasant associations (PAs). The seroprevalence of CBPP among adult animals was 8.5% (25) and in young 6.6% (6), in good body condition animals 6.6% (18) and in poor 11.5% (13), in dry season 11.9% (20) and in rainy 5.1% (11), and in highland altitude 2.5% (3), midland 3.8% (5), and lowland 17.4% (23). Among the potential predisposing factors assessed, altitude was found significantly (p = 0.02, OR = 7.3) associated with the seroprevalence of contagious bovine pleuropneumonia and other risk factors had no significant (P > 0.05) influence. The present study showed that the overall seroprevalence of CBPP in Gimbo district was high and this indicates a need for intervening and implementing control measures to prevent further spread of the disease in the district through the use of better and coordinated vaccination program.

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Ndungu, Virginia, Hellen Mberia, Kyalo Ngula, and Joseph Othieno. "The Influence of Communication Messages on Adoption of Contagious Bovine Pleuropneumonia (CBPP) Vaccine among Arid and Semi-Arid Lands (ASAL) Pastoralists in Kenya." International Journal of Communication and Public Relation 8, no. 2 (April 18, 2023): 40–54. http://dx.doi.org/10.47604/ijcpr.1940.

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Purpose: The purpose was to establish influence of communication messages on adoption of Contagious Bovine Pleuropneumonia (CBPP) Vaccine among Arid and Semi-Arid Lands (ASAL) pastoralists in Kenya. Messages were studied under parameters of inoculation site, benefits, required frequency of vaccination and side effects. The focus on the vaccine messaging was informed by the slow pace of adoption of live T1 vaccines currently being used to eradicate CBPP in Kenya. Diffusion of innovation and social learning theories were used to support the study. Methodology: Study population were pastoralists in Narok South Sub County. 468 respondents inclusive of qualitative and quantitative samples where 440 responded to questionnaire, 24 in focus group discussions, and 4 in key informant interviews participated. Multi stage, purposive, simple random, systematic and stratified sampling techniques were then employed to come up with respondents. Statistical Package for Social Scientists (SPSS) version 20.0 was used to analyze data, which was presented using regression coefficients and ANOVA. Findings: CBPP messaging influenced respondents to vaccinate although some had more influence than others. Messages on inoculation site, benefits, required frequency of vaccination side effects and communal vaccinations were important for the survival of their cattle and significantly influenced the decisions of respondents to vaccinate against the disease. Moreover, messages helped them to know important information details such as vaccination venues, and costs of vaccination and availability of the veterinary officers. CBPP vaccine messages attributes were key in the success of influencing respondents. However, the messaging ran into already held misinformation by some pastoralists confirming earlier study that vaccination rate was at 20-60% because some skipped the exercise. Unique Contribution to Theory, Practice and Policy: CBPP vaccine messages and attributes significantly influenced CBPP vaccinations decisions among pastoralists. This study validated diffusion of innovation and social learning theories that innovation-decision process is essentially an information seeking and processing activity in which an individual is motivated to reduce uncertainty about the advantages and disadvantages of the innovation. For policy and practice, this study recommends development of communication plans, and packaging of CBPP vaccine messages for dissemination in the ASALs where disease is prevalent. Considering that CBPP is a trans-boundary disease, these plans and messages could be harmonized across ASAL counties to enable consistency and coherence.

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More sources

Dissertations / Theses on the topic "CBPP"

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De, Santis Paola. "Contagious bovine pleuropneumonia (CBPP) : studies on the disease and causative agent (Mycoplasma mycoides subsp. mycoides SC)." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425092.

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Mtui-Malamsha, Niwael Jesse. "Contagious bovine pleuropneumonia (CBPP) in the Maasai ecosystem of south-western Kenya : evaluation of seroprevalence, risk factors and vaccine safety and efficacy." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4379.

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Contagious bovine pleuropneumonia (CBPP) is a bovine bacterial disease of major economic importance in sub-Saharan Africa. Vaccination has been recommended to control the disease in endemic areas such as the Maasai ecosystems of Kenya and Tanzania; however, the currently used live attenuated vaccine has been reported to have poor vaccine safety and efficacy. To compare standard (current) and an improved (buffered) version of the live CBPP-vaccine, several epidemiological studies were carried out in Maasai cattle in Kenya between 2006 and 2008. Specifically, the aims were to estimate CBPP seroprevalence at herd and animal level; to identify risk factors for seroprevalence at both levels; to investigate the spatial distribution of seroprevalence; to compare post vaccination adverse events in cattle vaccinated with a standard and a buffered vaccine, and finally to compare efficacy of the two vaccines to induce seroconversion and to prevent development of clinical signs suggestive of CBPP. A cross-sectional study was carried out in 6872 cattle in 175 randomly selected herds from Loita and Mara divisions. A competitive ELISA revealed that 85% of the herds in the area had at least one seropositive animal and that seropositive herds were harbouring 11% seropositive cattle. A complement fixation test revealed that 46% of the herds had at least one seropositive animal and that seropositive herds were harbouring 4% seropositive cattle. A multivariable logistic regression analysis of the seroprevalence indicated that previous vaccination against CBPP, a history of CBPP outbreaks in the herd, animal age and the location of the herd in the division of Mara were positively correlated to seroprevalence. To investigate the observed difference in herd seroprevalence between the two divisions further, a spatial analysis was conducted. A SatScan test revealed clusters in Mara in areas identified by veterinary personnel as CBPP ‘hot spots’. A logistic regression using spatial information identified that location in the midland agro-ecological zone or close to a river and vaccination were positively associated with seroprevalence. To compare safety and efficacy of a standard and a buffered vaccine, two cohorts of approximately 40,000 cattle were used. The study showed that within 100 days post vaccination, 6.2 cattle per 1000 vaccinates developed adverse events, 4.1 of which were specifically attributable to vaccination and ranging from swelling of the tail to the tail sloughing off. This study revealed a slightly higher incidence of adverse events in cattle vaccinated with the buffered vaccine compared to the standard vaccine. A comparison of the efficacy of the two vaccines revealed that cattle vaccinated with the buffered vaccine had higher odds of seroconversion and lower odds of developing symptoms of CBPP, three and twelve months post vaccination respectively. The epidemiological studies conducted clearly show wide spread seroprevalence in the Maasai cattle. Given the (spatial) heterogeneity observed, control measures should probably be targeted in areas of increased risk (clusters). However, positive association of vaccination and seropositivity call for better diagnostics tests that can differentiate vaccinated from infected animals. Vaccination with buffered vaccine resulted in increased seroconversion, decreased clinical signs indicative of CBPP post vaccination and low seroprevalence post ‘outbreak’. Nevertheless, the increase in adverse events related to the buffered vaccine calls for further research into safer CBPP vaccines.

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Mulongo, Musa Matsanza. "Evaluation of lipoprotein Q and L-a-glycerol-3-phosphate oxidase of mycoplasma mycoides subs. mycoides (small colony) as virulence factors in contagious bovine pleuropneumonia (CBPP) infections." Thesis, Royal Veterinary College (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558979.

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Malafosse, Maxime. "La blockchain en support aux communs." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0455.

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La blockchain et les communs sont deux concepts qui suscitent de plus en plus d’intérêt. Par des approches différentes, on prête à ces deux notions beaucoup d’espoir pour transformer notre société et répondre aux enjeux actuels de transition sociale et écologique. Pourtant peu de recherches les mettent en lien. D’autant plus que les travaux qui rapprochent la blockchain et les communs restent essentiellement théoriques. Nos recherches visent à mieux cerner comment la blockchain peut s’inscrire en support aux communs en situation réelle. Nous avons exploré plusieurs terrains qui incarnaient, de différentes manières, le rôle d’une technologie comme un outil au service d’une finalité collective. Nous avons commencé par observer la place centrale de la blockchain dans un dispositif sociotechnique de communs qui vise à produire et à autogérer la création monétaire (essai 1). Pour investir ce premier terrain de recherche, nous avons réalisé une étude de cas. Dans l’essai suivant, nous avons cherché à éclairer le rôle de la blockchain comme outil intégré dans un dispositif plus large d’expérimentation de communs de la donnée à l’échelle d’une ville (essai 2). Cette deuxième étude de cas a été murie par la réalisation d’une mission d’expertise de deux années dans un tiers lieu et s’est finalement focalisé sur le projet Européen DECODE. Enfin, notre dernier essai permet d’approfondir comment la blockchain pourrait permettre de soutenir économiquement les communs puisqu’elle bouleverse les perspectives de la monnaie par la démocratisation de ses formes alternatives, la facilitation de sa création et la complexification de son design (essai 3)
Blockchain and the commons are two concepts that are attracting more and more interest. Through different perspectives, these two notions raise a lot of hopes to transform our society and to answer the current challenges of social and ecological transition. However, there is little research linking them. Especially since the work that brings blockchain and the commons together remains essentially theoretical. Our work aims to better understand how blockchain can support the commons in real life situations. We explored several fields that embodied, in different ways, the role of a technology as a tool in the service of a collective purpose. We began by observing the key role of the blockchain in a commons that aims to produce and self-manage monetary creation (essay 1). To invest this first research field, we conducted a case study. In the following essay, we aimed to shed light on the role of blockchain as a tool integrated in a larger device for experimenting the data commons at the scale of a city (essay 2). This second case study was matured by the realization of a two-year expertise mission in a third place and finally focused on the European project DECODE. Finally, our last essay builds on the results of the first essay and explores how blockchain could economically support the commons as it disrupts the prospects of money through democratizing its alternative forms, facilitating its creation, and increasing the complexity of its design (essay 3)

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Sidibe, Cheick Abou Kounta. "Epidémiologie de la Péripneumonie Contagieuse bovine(PPCB) dans les régions du Delta Central du Mali : évaluation des performances de deux tests de diagnostic pour analyser la dynamique de transmission et développement d'outils d'aide à la décision pour la surveillance et le contrôle." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20019/document.

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Deux tests sérologiques (test de fixation de complément (CFT) et l'ELISA de compétition (cELISA)) sont recommandés par l'OIE et utilisés couramment au Laboratoire Central Vétérinaire de Bamako parfois en parallèle dans le diagnostic et le dépistage de la péripneumonie contagieuse bovine (PPCB). La performance de ces tests a été estimée différemment par plusieurs auteurs dans des contextes épidémiologiques différents à partir de méthodes statistiques standards avec un statut sanitaire réel des animaux partiellement ou totalement connu. Dans un milieu où la PPCB est endémique avec différents stades d'évolution de la maladie, sachant que les tests sérologiques sont non parfaits (non gold standards), l'utilisation d'une approche bayésienne semblait appropriée pour une appréciation précise des paramètres de performance de tests qui sont la sensibilité et la spécificité, afin de mieux apprécier la prévalence de la maladie dans le cheptel bovin du delta central du Niger au Mali. Les résultats d'analyse de laboratoire des échantillons de terrain ont servi de bases de données importantes pour une analyse descriptive de la situation épidémiologique par appréciation des patrons de variations des principaux paramètres pouvant exercer une influence majeure sur la propagation de la PPCB. Ceci, dans le but d'aider à la réflexion sur la recherche d'outils et stratégies nouvelles dans le processus de prévention et d'éradication de la PPCB par le développement des modalités d'implantation d'une méthodologie innovante, pratique et efficace comme la qualification sanitaire troupeau concernant la PPCB dans un environnement d'élevage extensif. Cette thèse a permis de mieux définir les corrélations entre les deux tests, d'observer une meilleure sensibilité de cELISA par rapport à CFT permettant de justifier son utilisation seule dans un programme de dépistage à large échelle de la PPCB dans un milieu endémique. La démonstration dans l'étude de l'existence d'agrégation des animaux séropositifs à l'échelle du troupeau et aussi géographique montre qu'un système de qualification sanitaire troupeau pourrait jouer en collaboration avec le réseau national de surveillance épidémiologique vétérinaire, un rôle prépondérant dans la lutte ciblée et la maîtrise de la propagation de la PPCB au Mali. Mots clefs : PPCB-cELISA-CFT-Approche bayésienne-Agrégation-qualification sanitaire-Bovin
Two serological tests (complement fixation test (CFT) and competitive ELISA (cELISA)) are recommended by the OIE and commonly used in Central Veterinary Laboratory of Bamako sometimes in parallel, in the diagnosis and screening for contagious (CBPP). The performance of these tests has been estimated differently by several authors in different epidemiological settings using standard statistical methods with a real status of animals partially or completely known. In an environment where CBPP is endemic and where different stages of disease are available, given that serological tests are not perfect (not gold standard), the use of Bayesian approach seemed appropriate for an accurate assessment of the performance parameters of tests which are the sensitivity, specificity and predictive values to better assess the prevalence of the disease in cattle in the central Niger delta in Mali. The results of laboratory analysis of field samples were used as large database for epidemiological analysis of the geographical distribution of seroprevalence and the influence of major risk factors for the spread of CBPP. This, in order to aid reflection on tools research and new strategies in the process of prevention and eradication of CBPP by developing for implementation of an innovative, practical and effective methodology as sanitary qualification of cattle. This thesis has helped define the correlations between the two tests, observing a better sensitivity of cELISA compared to CFT to justify its use only in a program of widespread testing of CBPP in an endemic environment. In this study, the proof of the existence of aggregation of seropositive animals across herds and geographical level shows that a sanitary qualification system of cattle can play in collaboration with the national network of veterinary epidemiological surveillance a leadership role in targeted control and mastery of the spread of CBPP in Mali.Keys words: CBPP- cELISA - CFT- Bayesian approach -Aggregation- Sanitary qualification –Bovine

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6

Hamsten, Carl. "Protein based approaches to understand and prevent contagious bovine pleuropneumonia." Doctoral thesis, KTH, Proteomik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11108.

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Contagious bovine pleuropneumonia (CBPP) is a severe infectious disease caused by Mycoplasma mycoides subsp. mycoides small colony type (M. mycoides SC) and is a vast problem in Africa. Current CBPP prevention is based on attenuated live strain vaccines, but these are limited by factors such as short-term immunity, cold-chain dependence and retained virulence. CBPP can be diagnosed using post-mortem examination, identification of the agent using culture and PCR based methods as well as serological diagnostic methods, but the latter are generally not sensitive enough and there is also demand for an inexpensive, pen side field test.The research presented in this thesis was focused on using recombinantly expressed surface proteins from M. mycoides SC to characterize humoral immune responses to CBPP. Thereby candidate proteins to be used in development of serological diagnostic methods and possibly subunit vaccines could be identified. As a first step, five putative variable surface proteins of M. mycoides SC were expressed and purified from E. coli in Paper I. These proteins were analyzed using immunoblotting techniques and results showed that one protein, MSC_0364, was variably expressed on the surface of M. mycoides SC in vitro. Paper II presents expanded efforts including cloning and expression of 64 recombinant surface proteins and an assay for high throughput analysis of protein-specific IgG, IgA and IgM titers in hundreds of sera using a bead-based screening assay. The assay was evaluated by protein-specific inhibition experiments, comparisons to Western blotting and monitoring of immune responses over time in a study with sera taken from eight animals over 293 days from a previous vaccine trial.Papers III and IV present applications using the recombinant proteins and bead-based screening assay wherein proteins for diagnostic and vaccine development were identified. In Paper III, the assay was used to screen 61 proteins using well-characterized serum samples from cattle with CBPP and healthy controls, resulting in selection of eight proteins suitable for diagnostic use. These proteins were combined and evaluated in a proof-of-concept ELISA with a discriminative power that enabled 96% correct classification of sera from CBPP-affected and CBPP-free bovines. Paper IV reports the results and protein-specific analyses of a vaccine trial using the recombinant putative variable surface proteins presented in Paper I as a subunit vaccine. The vaccine conferred no protection, but a weak vaccine response could not be excluded as the cause of failure. In an effort to identity other protein candidates to be used in a subunit vaccine, protein-specific analysis of humoral immune responses elicited by the currently approved live strain vaccine, T1/44, were investigated. Here, five proteins with high IgG titers associated to immunity were identified: LppQ, MSC_02714, MSC_0136, MSC_0079 and MSC_0431. These proteins may be important in the development of a novel subunit vaccine against CBPP.
QC 20100719

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Kronekova, Zuzana. "Assembly of mitochondrial ubiquinol-cytochrome c oxidoreductase complex in yeast Saccharomyces cerevisiae: The role of Cbp3p and Cbp4p assembly factors." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2005. http://nbn-resolving.de/urn:nbn:de:swb:14-1122027648324-54732.

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Ubiquinol-cytochrome c reductase (complex III) is a central component of the respiratory chain of the inner mitochondrial membrane. It transfers electrons from reduced ubiquinone to ferricytochrome c. Correctly assembled and functional complex III is an essential prerequisite for oxidative energy metabolism. Complex III deficiency has been reported to be associated with several neurodegenerative diseases. Formation and assembly of complex III requires a multitude of specific nuclearly encoded proteins. For example, gene specific translational activators for cytochrome b synthesis as well as three non-subunit proteins, which are important for assembly and/or stability have been detected. The role of Bcs1p in assembly of Rieske FeS protein and Qcr10p into complex III has been clasified recently. The role of the two putative chaperones, Cbp3p and Cbp4p, is not known. In spite of the similar phenotype of cbp3D and cbp4D strains, that suggests the role of both proteins in the same step of complex III assembly, we were able for the first time to demonstrate differences on the molecular level between both deletion mutants. We show by BN-PAGE that cbp3D and cbp4D mutants are disturbed in complex III assembly and accumulate intermediate-sized forms of the complex. Moreover deletion of CBP3 interferes with the formation of complex III/IV supracomplexes. Our studies show that Cbp3p and Cbp4p interact and are present in high molecular weight complexes, some of which might represent intermediates of complex III assembly. Overexpression of Cbp4p cannot substitute for the function of Cbp3p, but high level expression of Cbp3p can partially compensate for the lack of Cbp4p. Because lipids play an important role for complex III assembly and stability, we analysed the mitochondrial lipid composition of cbp3D and cbp4D mutants. Our data show that mitochondria of both mutants exhibit a wild type-like lipid composition, that favors the idea that Cbp3p and Cbp4p are specific assembly factors for complex III rather than components of the mitochondrial lipid metabolism. By complementation studies we have shown that Cbp3 proteins of S. cerevisiae, S. pombe and human are (partially) functional homologues. A yeast model based on chimeric constructs of S. cerevisiae and human proteins was constructed, which allows to test the pathogenicity of human mutations. To define the role/s of Cbp3p and Cbp4p in the assembly pathway of complex III, interactions of selected subunits with both assembly factors were analysed by TAP- or co-immunoprecipitation. Based on the results of Cbp3p and Cbp4p topologies, BN-PAGE analysis of null mutant strains and interaction studies a model for complex III assembly and the roles of Cbp3p and Cbp4p in this process are proposed. I present a hypothesis, according to which Cbp3p and Cbp4p form a ?scaffold? for the assembly of all three putative sub-complexes, may act independently in the first steps of bc1 complex assembly (e. g. the formation of sub-complexes) and interact together to assist the final assembly of sub-complexes into a mature enzyme
Der Ubiquinol-Cytochrom c Reductase (Komplex III) ist eine zentrale Komponente der Atmungskette der inneren Mitochondrienmembran. Er transferiert Elektronen von reduziertem Ubiquinon auf Ferricytochrom c. Der korrekt assemblierte und funktionale Komplex III ist eine essenzielle Voraussetzung für den oxidativen Energiemetabolismus. Komplex III Defizienz ist assoziiert mit verschiedenen neurodegenerativen Krankheiten

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Gruschke, Steffi. "Early steps in the biogenesis of the bc1 complex in yeast mitochondria : The role of the Cbp3-Cbp6 complex in cytochrome b synthesis and assembly." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81033.

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The inner membrane of mitochondria harbors the complexes of the respiratory chain and the ATP synthase, which perform the key metabolic process oxidative phosphorylation. These complexes are composed of subunits from two different genetic origins: the majority of constituents is synthesized on cytosolic ribosomes and imported into mitochondria, but a handful of proteins, which represent core catalytic subunits, are encoded in the organellar DNA and translated on mitochondrial ribosomes. Using yeast as a model organism, I investigated the mitochondrial ribosomal tunnel exit, the region of the ribosome where the nascent chain emerges and that in cytosolic ribosomes serves as a platform to bind biogenesis factors that help the newly synthesized protein to mature. This study provided insights into the structural composition of this important site of mitochondrial ribosomes and revealed the positioning of Cbp3 at the tunnel exit region, a chaperone required specifically for the assembly of the bc1 complex. In my further work I found that Cbp3 structurally and functionally forms a tight complex with Cbp6 and that this complex exhibits fundamental roles in the biogenesis of cytochrome b, the mitochondrially encoded subunit of the bc1 complex. Bound to the ribosome, Cbp3-Cbp6 stimulates translation of the cytochrome b mRNA (COB mRNA). Cbp3-Cbp6 then binds the fully synthesized cytochrome b, thereby stabilizing and guiding it further through bc1 complex assembly. The next steps involve the recruitment of the assembly factor Cbp4 to the Cbp3-Cbp6/cytochrome b complex and presumably acquisition of two redox active heme b cofactors. During further assembly Cbp3-Cbp6 is released from cytochrome b, can again bind to the ribosome and activate further rounds of COB mRNA translation. The dual role of Cbp3-Cbp6 in both translation and assembly allows the complex to act as a regulatory switch to modulate the level of cytochrome b synthesis in response to the bc1 complex assembly process.

At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Manuscript.

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Cummings, Cory R. "The Anatomy of CBPR: A Case Study of CBPR Implementation for Health Promotion with the Peer Community." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4966.

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This case study is a qualitative examination of a health promotion project conducted in collaboration with members of the mental health peer community. More specifically, it explores the community based participatory research (CBPR) implementation process used to conduct this health promotion project to gain a deeper understanding of the mechanisms at work in the implementation process. While there has been considerable attention to the principles that guide CBPR (Braun et al., 2012; Israel et al., 2008; LaVeaux & Christopher, 2009), there remains important work to be done in bridging these principles to implementation; what processes or mechanisms translate these principles to action. Four mechanisms were initially proposed by this writer, derived from extant literature in this area (Wallerstein & Duran, 2003). These provided the initial framework for analyzing the data gathered throughout the case study. The case report discusses the findings of how these initially proposed mechanisms have been transformed and redefined in the context of this case. The resultant mechanisms, knowledge sharing, power sharing, task sharing, resource sharing, and shared purpose (there are five, as one additional new mechanism emerged in the analysis), are described with examples of how they were reflected in this case. Implications for these findings for CBPR research, collaborative health promotion with the mental health peer community, and the social work profession are shared.

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Islas-Osuna, Maria A. "Genetic analysis of the Cbp1-COB mRNA interaction and the role of Cbp1 in translation of COB RNAs." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/279945.

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Mitochondria are the organelles where respiration occurs. The yeast mitochondrial genome encodes only 8 proteins, therefore the organelle depends on the nuclear genome for many proteins required in different steps of mitochondrial gene expression. Regulation of mRNA stability, processing and translation are important steps in gene expression within the mitochondrion. Cbp1, a protein encoded by the nuclear gene CBP1, is required specifically for stabilization of precursor and mature cytochrome b (COB) RNA, which is encoded in the mitochondrial genome. Previous work identified a cis-element, CCG, in the 5' untranslated region (UTR) of COB, that is critical for the Cbp1-dependent stability of COB mRNA. Mutation of any single nucleotide resulting in an A̲CG, CA̲G or CCU̲ triplet causes destabilization of COB mRNA and concomitant loss of respiratory capability. In the present study, suppressors were selected in the CCU strain in an effort to define important sites in Cbp1 for protection of COB mRNA. The mitochondrial mutant strain CCU is conditional; it grows slowly at 25°C but does not grow at 18°C or 33°C on the non-fermentable carbon source glycerol. Twelve dominant suppressors in CBP1 were obtained. They define two main groups, based on the pattern of growth on glycerol at different temperatures. The CBP1-encoded suppressors make strains containing the mitochondrial CCU̲ mutation respiratory competent at 33°C by allowing accumulation of mature COB mRNA. Suppressors that map to the carboxyl half of Cbp1, such as S289G, S330R, Q358K, Q358R, L489W, K532M, D533Y and I638M, rescue the temperature-sensitive (ts) phenotype caused by the CCU̲ mutation. The suppressors that map to the amino half of Cbp1, such as K205R, E241G, I249T, N281D and I293L, rescue the ts phenotype to a lesser extent than the suppressors that map to the carboxyl half of Cbp1. These results suggest that the two halves of Cbp1 have different functions in the processing and stability of COB transcripts. The hypothesis that Cbp1 has a role in translation of cytochrome b (COB) mRNA was not testable previously, since disruption of CBP1 results in instability and degradation of COB mRNA. In a Δpet127 strain, COB precursor mRNA is not processed to the mature 5' site and thus accumulates to levels equivalent to that of the wild-type mature mRNA (Wiesenberger and Fox, 1997). Null alleles of pet127 were selected as suppressors of A̲CG and CCU̲ mutations in COB. COB precursor mRNA levels in these strains were similar to the Δpet127 strain with a wild-type mitochondrial genome (Chen et al., 1999). In the present study, the effect of deleting CBP1 in a Δpet127 strain was measured. Strain Δcbp1 Δpet127 accumulated no mature COB mRNA but high levels of COB precursor mRNA. The levels of precursor mRNA in the Δcbp1 Δpet127 strain were 3-fold higher than in wild-type strain and approaching 60% of wild-type mature levels (wild-type COB precursor is 18% of mature COB mRNA). Absolutely no apocytochrome b protein was detected in the Δcbp1 Δpet127 strain. This result suggests that Cbp1 is required for translation of the COB message. Future experiments to determine the role of Cbp1 in the translation of COB mRNA are described.

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Books on the topic "CBPP"

1

FAO-OIE-AU/IBAR-IAEA Consultative Group on Contagious Bovine Pleuropneumonia. and Consultative Group Meeting on CBPP in Africa (3rd : 2003 : Rome, Italy), eds. Towards sustainable CBPP control programmes for Africa: FAO-OIE-AU/IBAR-IAEA Consultative Group on Contagious Bovine Pleuropneumonia third meeting, Rome, 12-14 November 2003. Rome: Food and Agriculture Organization of the United Nations, 2004.

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ARC-Onderstepoort OIE International Congress (1998 Berg-en-Dal, South Africa). Proceedings of the ARC-Onderstepoort OIE International Congress with WHO-cosponsorship on anthrax, brucellosis, CBPP, clostridial and mycobacterial diseases: Berg-en-Dal, Kruger National Park, South Africa, 9-15 August 1998. Onderstepoort, South Africa: Onderstepoort Veterinary Institute, 1998.

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Communities, United States Environmental Protection Agency Office of Sustainable Ecosystems and. Community-based environmental protection(CBEP): Characterization of EPA Regional CBEP Activities. Chicago, Ill: U.S. Environmental Protection Agency, 1999.

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U.S. Environmental Protection Agency Office of Sustainable Ecosystems and Communities. Community-based environmental protection(CBEP): Accomplishments and value-added of EPA CBEP projects. Fairfax, VA: ICF Incorporated, 1999.

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Phillips, Joseph. CBAP Certified Business Analysis Professional. New York: McGraw-Hill, 2009.

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Alves, Aristides. Patrimônio mineral da Bahia: CBPM, 35 anos = Bahia's mineral wealth : CBPM - marking thirty-five years. Edited by Falcón Gustavo and Companhia Baiana de Pesquisa Mineral. Salvador, Bahia: Companhia Baiana de Pesquisa Mineral, Governo da Bahia, Secretaria da Indústria, Comércio e Mineração, 2008.

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Harrison, Donald D. CBP x-ray workbook. [S.l.]: Donald D. Harrison, 1989.

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U.S. Customs and Border Protection. CBP inspector's field manual. Washington, D.C: American Immigration Lawyers Association, 2008.

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India. Central Board of Irrigation and Power., ed. Commemorative volume, CBIP diamond jubilee, 1927-87. New Delhi: Central Board of Irrigation and Power, 1987.

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1959-, Wagner Terri A., and ebrary Inc, eds. CBAP / CCBA: Certified business analysis study guide. Indianapolis, Ind: Wiley Pub., 2011.

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Book chapters on the topic "CBPP"

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Jayaram, Jayapradha, Prakash Manickam, Apoorva Gupta, and Madhuri Rudrabhatla. "CBPP." In Machine Learning Algorithms and Applications in Engineering, 195–211. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003104858-12.

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Grace, Delia, Tadelle Dessie, Michel Dione, Henry Kiara, Anne Liljander, Jeff Mariner, Jan Naessens, et al. "Transboundary animal diseases." In The impact of the International Livestock Research Institute, 274–301. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789241853.0274.

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Abstract Transboundary animal diseases (TADs) are highly contagious epidemics with the potential for very rapid spread, causing serious economic and sometimes public health consequences while threatening farmers' livelihoods. TADs often cause high morbidity and mortality in susceptible animal populations. Some TADs are also emerging infectious diseases, food-borne diseases and/or zoonoses: these are covered in other chapters. This chapter covers those high-impact, highly contagious animal diseases, such as foot-andmouth disease (FMD), that do not infect humans but do affect food and nutrition security and trade that the International Livestock Research Institute (ILRI) has been working on since the 1990s. These are: African swine fever (ASF), mycoplasma disease (both contagious bovine pleuropneumonia (CBPP) and contagious caprine pleuropneumonia (CCPP)), peste des petits ruminants (PPR) and Newcastle disease (ND). Other TADs, which were to a lesser degree the focus of ILRI research, are briefly mentioned (including FMD, classical swine fever (CSF) and rinderpest).

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van Roy, Frans, Volker Nimmrich, Anton Bespalov, Achim Möller, Hiromitsu Hara, Jacob P. Turowec, Nicole A. St. Denis, et al. "CBP1." In Encyclopedia of Signaling Molecules, 260. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100171.

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Levy, Paul Blain. "Simple Models of CBPV." In Call-By-Push-Value, 89–116. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-007-0954-6_5.

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Shelvock, Matthew T. "Case Studies in CBMP." In Cloud-Based Music Production, 149–56. New York : Routledge, 2020. | Series: Perspectives on music production: Focal Press, 2020. http://dx.doi.org/10.4324/9781351137102-6.

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Turnell, Andrew S. "CBP/p300 Coactivators." In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_899-2.

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Turnell, Andrew S. "CBP/p300 Coactivators." In Encyclopedia of Cancer, 833–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46875-3_899.

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Sverdlikov, Anatoliy I., Gennadij P. Shcherbina, Michail M. Zemljak, Alexander A. Sverdlikov, Donald H. Haycock, Andrew Lugowski, George Nakhla, Lawrence K. Wang, and Yung-Tse Hung. "Column Bioreactor Clarifier Process (CBCP)." In Advanced Biological Treatment Processes, 313–63. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-170-7_9.

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Levy, Paul Blain. "Recursion and Infinitely Deep CBPV." In Call-By-Push-Value, 65–86. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-007-0954-6_4.

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Shelvock, Matthew T. "Making Music Using CBMP Resources." In Cloud-Based Music Production, 50–95. New York : Routledge, 2020. | Series: Perspectives on music production: Focal Press, 2020. http://dx.doi.org/10.4324/9781351137102-3.

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Conference papers on the topic "CBPP"

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Silva, Renan F. F. da, Yulle G. F. Borges, and Rafael C. S. Schouery. "Heurísticas para o Problema do Empacotamento Colorido." In Encontro de Teoria da Computação. Sociedade Brasileira de Computação - SBC, 2021. http://dx.doi.org/10.5753/etc.2021.16374.

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O Problema do Empacotamento Colorido (CBPP) é uma generalização do Problema do Empacotamento (BPP) onde, dado um conjunto de itens com um tamanho e uma cor, devemos empacotar os itens em recipientes de capacidade limitada, minimizando a quantidade de recipientes utilizados e satisfazendo a restrição que dois itens de mesma cor não podem ser empacotados lado a lado em um mesmo recipiente. Neste artigo, propomos a adaptação de heurísticas do BPP para o CBPP acompanhado de algumas heurísticas novas para o problema. Propomos também uma heurística para o CBPP baseada em Variable Neighborhood Search. Os resultados indicam que a nossa abordagem é capaz de encontrar boas soluções para instâncias grandes do problema.

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Anh Vang, Tran, Xianmin Zhang, and Benliang Zhu. "Design and Optimization of a Highly Sensitive and Linearity Piezoresistive Pressure Sensor Based on a Combination of Cross Beam-Peninsula-Membrane Structure." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70485.

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The sensitivity and linearity trade-off problem has become the hotly important issues in designing the piezoresistive pressure sensors. To solve these trade-off problems, this paper presents the design, optimization, fabrication, and experiment of a novel piezoresistive pressure sensor for micro pressure measurement based on a combined cross beam - membrane and peninsula (CBMP) structure diaphragm. Through using finite element method (FEM), the proposed sensor performances as well as comparisons with other sensor structures are simulated and analyzed. Compared with the cross beam-membrane (CBM) structure, the sensitivity of CBMP structure sensor is increased about 38.7 % and nonlinearity error is reduced nearly 8%. In comparison with the peninsula structure, the maximum non-linearity error of CBMP sensor is decreased about 40% and the maximum deflection is extremely reduced 73%. Besides, the proposed sensor fabrication is performed on the n-type single crystal silicon wafer. The experimental results of the fabricated sensor with CBMP membrane has a high sensitivity of 23.4 mV/kPa and a low non-linearity of −0.53% FSS in the pressure range 0–10 kPa at the room temperature. According to the excellent performance, the sensor can be applied to measure micro-pressure lower than 10 kPa.

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Barros, Carla Osthoff. "O Sistema Multiprocessador ACP no CBPF." In Simpósio Brasileiro de Arquitetura de Computadores e Processamento Paralelo. Sociedade Brasileira de Computação, 1988. http://dx.doi.org/10.5753/sbac-pad.1988.23539.

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O Centro Brasileiro de Pesquisas Físicas, CBPF, em colaboração com o Fermi National Accelerator Laboratory, FERMILAB, está participando do desenvolvimento de sistemas de multiprocessadores paralelos de baixo custo efetivo capazes de satisfazer não só aos problemas de computação da Física de Altas Energias como também de outras áreas de pesquisa científica. O CBPF possui no momento um sistema de 21 processadores e está desenvolvendo software básico e aplicativo em colaboração com outras instituições.

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VenkataSwamy, M., Srini Ramaswamy, and Nitin Agarwal. "CBPM: Context Based Privacy Model." In 2010 IEEE Second International Conference on Social Computing (SocialCom). IEEE, 2010. http://dx.doi.org/10.1109/socialcom.2010.156.

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Arita, H., and T. Nakano. "INFLUENCE OF β-LACTAM ANTIBIOTICS ON THE PLATELETS IN VITRO EFFECTS OF SOME β-LACTAM ANTIBIOTICS ON THE BIOCHEMICAL RESPONSES OF RAT PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644814.

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The inhibitory mechanism of 3-lactam antibiotics on rat platelets were studied using carbenicil1 in (CBPC) as a representative of the antibiotics. CBPC suppressed all the thrombin-induced cellular responses including shape change, secretion, and aggregation, however, it only suppressed aggregation of ADP-induced responses. This suggests that ADP binding to its own receptor was not affected by the drug while that of thrombin was inhibited. Inhibition of thrombinbinding was confirmed using 125CQSe 0f ADP-stimulated platelets, fibrinogen binding, which has an essential role for ADP-induced primary aggregation, was significantly suppressed by CBPC. Increase of a net negative charge of the membrane surface was observed after treatment of the platelets with antibiotics, and good correlation was obtained between suppression of the platelet responses and degree of net negativecharge of the antibiotics especially on the penicillin analogues. These findings strongly suggest that the inhibition of ligand binding to their own receptors is due to the increase of the negative charge of the platelet membranes which is probably caused by the antibiotic bound to the platelet membrane

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Choong, Yeow Wei, Lisa Di Jorio, Anne Laurent, Dominique Laurent, and Maguelonne Teisseire. "CBGP: Classification Based on Gradual Patterns." In 2009 International Conference of Soft Computing and Pattern Recognition. IEEE, 2009. http://dx.doi.org/10.1109/socpar.2009.15.

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Raiser, George F., and Dudi Amir. "Solder Joint Reliability Improvement Using the Cold Ball Pull Metrology." In ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems collocated with the ASME 2005 Heat Transfer Summer Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/ipack2005-73045.

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The various methods for improvement of package solder joint reliability (SJR) have centered on the broad categories of (i) reductions in the thermomechanical and mechanical stresses and strains applied to the joints, and (ii) strengthening of the solder interconnect interfaces and materials themselves. In practice, the success of the former depends first and foremost on the latter — an adequate and consistent interconnect ‘strength’ during the package development and production cycles. With the advancement of various pad-plating technologies (most notably ENIG – Electroless Nickel Immersion Gold), sphere chemistries, fluxes and processing conditions, each with their own stability issues, the interconnect strengths can easily undergo seemingly random drifts over time. The Dage™ Cold Ball Pull (CBP) technique, however, has emerged as an attractive alternative to the traditional ball-shear metrology as an interconnect strength monitor. The open issues preventing its adoption are related to identifying the best test conditions (e.g. aging time, pull speed, jaw pressure, etc...), all of which are addressed here. After identifying the best test conditions, we present a number of experimental results that highlight the powerful capability of this tool for optimizing and monitoring solder-joint strength. A full metrology characterization to demonstrate accuracy, repeatability and reproducibility has been performed. Moreover, interesting results have been obtained with respect to solder-aging, multiple-reflow, and time-above-liquidus effects on interconnect strength. Examples of direct correlation between CBP measurements and solder-joint shock performance are demonstrated. CBP is also shown to correlate well to other strength metrologies, such as three-point bend. Finally, CBP is used here to show how to strengthen interconnects by the proper selection of pad plating chemistries, sphere compositions, fluxes, reflow conditions, etc… Maintaining those strengths through development and production can be handled effectively using CBP as a monitor. Looking forward, CBP data presented here shows that certain material and processing choices can maximize lead-free solder interconnect strength and lead-free solder joint reliability.

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Kamaleswaran, R., and C. McGregor. "CBPsp: Complex Business Processes for Stream Processing." In 2012 25th IEEE Canadian Conference on Electrical and Computer Engineering (CCECE). IEEE, 2012. http://dx.doi.org/10.1109/ccece.2012.6334907.

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Guo, Yunhui, Congfu Xu, Hanzhang Song, and Xin Wang. "Understanding Users' Budgets for Recommendation with Hierarchical Poisson Factorization." In Twenty-Sixth International Joint Conference on Artificial Intelligence. California: International Joint Conferences on Artificial Intelligence Organization, 2017. http://dx.doi.org/10.24963/ijcai.2017/247.

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People consume and rate products in online shopping websites. The historical purchases of customers reflect their personal consumption habits and indicate their future shopping behaviors. Traditional preference-based recommender systems try to provide recommendations by analyzing users' feedback such as ratings and clicks. But unfortunately, most of the existing recommendation algorithms ignore the budget of the users. So they cannot avoid recommending users with products that will exceed their budgets. And they also cannot understand how the users will assign their budgets to different products. In this paper, we develop a generative model named collaborative budget-aware Poisson factorization (CBPF) to connect users' ratings and budgets. The CBPF model is intuitive and highly interpretable. We compare the proposed model with several state-of-the-art budget-unaware recommendation methods on several real-world datasets. The results show the advantage of uncovering users' budgets for recommendation.

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Bouroumi, Jamal EL, Hatim Guermah, Mahmoud Nassar, and Abdelaziz Kriouile. "CBPM: An Approach for Contextual Business Process Modeling." In 2020 Fourth International Conference On Intelligent Computing in Data Sciences (ICDS). IEEE, 2020. http://dx.doi.org/10.1109/icds50568.2020.9268681.

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Reports on the topic "CBPP"

1

Slezak, T., and M. Wolinsky. FY02 CBNP Annual Report Input: Bioinformatics Support for CBNP Research and Deployments. Office of Scientific and Technical Information (OSTI), October 2002. http://dx.doi.org/10.2172/15002105.

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Smith, F., K. Brown, G. Flach, and S. Sarkar. CBP PHASE I CODE INTEGRATION. Office of Scientific and Technical Information (OSTI), September 2011. http://dx.doi.org/10.2172/1026836.

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Hunag, Haojie. CBP and p27KIP1 in Prostate Carcinogenesis. Fort Belvoir, VA: Defense Technical Information Center, February 2008. http://dx.doi.org/10.21236/ada482547.

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Morrison, Mark, and Joshuah Miron. Molecular-Based Analysis of Cellulose Binding Proteins Involved with Adherence to Cellulose by Ruminococcus albus. United States Department of Agriculture, November 2000. http://dx.doi.org/10.32747/2000.7695844.bard.

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Abstract:

At the beginning of this project, it was clear that R. albus adhered tightly to cellulose and its efficient degradation of this polysaccharide was dependent on micromolar concentrations of phenylacetic acid (PAA) and phenylpropionic acid (PPA). The objectives for our research were: i) to identify how many different kinds of cellulose binding proteins are produced by Ruminococcus albus; ii) to isolate and clone the genes encoding some of these proteins from the same bacterium; iii) to determine where these various proteins were located and; iv) quantify the relative importance of these proteins in affecting the rate and extent to which the bacterium becomes attached to cellulose. BARD support has facilitated a number of breakthroughs relevant to our fundamental understanding of the adhesion process. First, R. albus possesses multiple mechanisms for adhesion to cellulose. The P.I.'s laboratory has discovered a novel cellulose-binding protein (CbpC) that belongs to the Pil-protein family, and in particular, the type 4 fimbrial proteins. We have also obtained genetic and biochemical evidence demonstrating that, in addition to CbpC-mediated adhesion, R. albus also produces a cellulosome-like complex for adhesion. These breakthroughs resulted from the isolation (in Israel and the US) of spontaneously arising mutants of R. albus strains SY3 and 8, which were completely or partially defective in adhesion to cellulose, respectively. While the SY3 mutant strain was incapable of growth with cellulose as the sole carbon source, the strain 8 mutants showed varying abilities to degrade and grow with cellulose. Biochemical and gene cloning experiments have been used in Israel and the US, respectively, to identify what are believed to be key components of a cellulosome. This combination of cellulose adhesion mechanisms has not been identified previously in any bacterium. Second, differential display, reverse transcription polymerase chain reaction (DD RT-PCR) has been developed for use with R. albus. A major limitation to cellulose research has been the intractability of cellulolytic bacteria to genetic manipulation by techniques such as transposon mutagenesis and gene displacement. The P.I.'s successfully developed DD RT- PCR, which expanded the scope of our research beyond the original objectives of the project, and a subset of the transcripts conditionally expressed in response to PAA and PPA have been identified and characterized. Third, proteins immunochemically related to the CbpC protein of R. albus 8 are present in other R. albus strains and F. intestinalis, Western immunoblots have been used to examine additional strains of R. albus, as well as other cellulolytic bacteria of ruminant origin, for production of proteins immunochemically related to the CbpC protein. The results of these experiments showed that R. albus strains SY3, 7 and B199 all possess a protein of ~25 kDa which cross-reacts with polyclonal anti-CbpC antiserum. Several strains of Butyrivibrio fibrisolvens, Ruminococcus flavefaciens strains C- 94 and FD-1, and Fibrobacter succinogenes S85 produced no proteins that cross-react with the same antiserum. Surprisingly though, F. intestinalis strain DR7 does possess a protein(s) of relatively large molecular mass (~200 kDa) that was strongly cross-reactive with the anti- CbpC antiserum. Scientifically, our studies have helped expand the scope of our fundamental understanding of adhesion mechanisms in cellulose-degrading bacteria, and validated the use of RNA-based techniques to examine physiological responses in bacteria that are nor amenable to genetic manipulations. Because efficient fiber hydrolysis by many anaerobic bacteria requires both tight adhesion to substrate and a stable cellulosome, we believe our findings are also the first step in providing the resources needed to achieve our long-term goal of increasing fiber digestibility in animals.

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Smith, F., G. Flach, and K. BROWN. CBP TOOLBOX VERSION 2.0: CODE INTEGRATION ENHANCEMENTS. Office of Scientific and Technical Information (OSTI), June 2013. http://dx.doi.org/10.2172/1090364.

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Shriver, Craig D., and Lee Bronfman. Comprehensive Reproductive System Care Program - Clinical Breast Care Project (CRSCP-CBCP). Fort Belvoir, VA: Defense Technical Information Center, January 2013. http://dx.doi.org/10.21236/ada612767.

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Shriver, Craig. Comprehensive Reproductive Systems Care Program (CRSCP) Clinical Breast Care Project (CBCP). Fort Belvoir, VA: Defense Technical Information Center, April 2012. http://dx.doi.org/10.21236/ada561558.

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Shriver, Craig D., and Lee Bronfman. Comprehensive Reproductive System Care Program - Clinical Breast Care Project (CRSCP-CBCP). Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada561578.

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Shriver, Craig D., and Lee Bronfman. Comprehensive Reproductive System Care Program- Clinical Breast Care Project (CRSCP-CBCP). Fort Belvoir, VA: Defense Technical Information Center, April 2014. http://dx.doi.org/10.21236/ada600420.

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Shriver, Craig D. Comprehensive Reproductive System Care Program - Clinical Breast Care Project (CRSCP-CBCP). Fort Belvoir, VA: Defense Technical Information Center, April 2013. http://dx.doi.org/10.21236/ada601290.

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