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Journal articles on the topic 'CCCTC-binding factor'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wendt, Kerstin S., Keisuke Yoshida, Takehiko Itoh, et al. "Cohesin mediates transcriptional insulation by CCCTC-binding factor." Nature 451, no. 7180 (2008): 796–801. http://dx.doi.org/10.1038/nature06634.

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2

Zlatanova, J., and P. Caiafa. "CCCTC-binding factor: to loop or to bridge." Cellular and Molecular Life Sciences 66, no. 10 (2009): 1647–60. http://dx.doi.org/10.1007/s00018-009-8647-z.

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3

Li, Tie, Zhenyu Lu, and Luo Lu. "Pax6 Regulation in Retinal Cells by CCCTC Binding Factor." Investigative Opthalmology & Visual Science 47, no. 12 (2006): 5218. http://dx.doi.org/10.1167/iovs.06-0254.

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4

Caiafa, Paola, and Jordanka Zlatanova. "CCCTC-binding factor meets poly(ADP-ribose) polymerase-1." Journal of Cellular Physiology 219, no. 2 (2009): 265–70. http://dx.doi.org/10.1002/jcp.21691.

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5

Sekiya, Takeshi, Kensaku Murano, Kohsuke Kato, Atsushi Kawaguchi, and Kyosuke Nagata. "Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity." FEBS Open Bio 7, no. 3 (2017): 397–404. http://dx.doi.org/10.1002/2211-5463.12189.

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6

Chan, Chang S., and Jun S. Song. "CCCTC-Binding Factor Confines the Distal Action of Estrogen Receptor." Cancer Research 68, no. 21 (2008): 9041–49. http://dx.doi.org/10.1158/0008-5472.can-08-2632.

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7

Hijazi, A. "Investigating the role of CCCTC-binding factor in osteoarthritis pathogenesis." Osteoarthritis and Cartilage 26 (April 2018): S154. http://dx.doi.org/10.1016/j.joca.2018.02.332.

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8

Guastafierro, Tiziana, Barbara Cecchinelli, Michele Zampieri, et al. "CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery." Journal of Biological Chemistry 283, no. 32 (2008): 21873–80. http://dx.doi.org/10.1074/jbc.m801170200.

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9

Zimmerman, Devon, Krupa Patel, Matthew Hall, and Jacob Elmer. "Enhancement of transgene expression by nuclear transcription factor Y and CCCTC‐binding factor." Biotechnology Progress 34, no. 6 (2018): 1581–88. http://dx.doi.org/10.1002/btpr.2712.

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10

Gao, J., T. Li, and L. Lu. "Functional role of CCCTC binding factor in insulin-stimulated cell proliferation." Cell Proliferation 40, no. 6 (2007): 795–808. http://dx.doi.org/10.1111/j.1365-2184.2007.00472.x.

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11

Wang, Feng, Jinghua Han, Li Wang, et al. "CCCTC-Binding Factor Transcriptionally Targets Wdr5 to Mediate Somatic Cell Reprogramming." Stem Cells and Development 26, no. 10 (2017): 743–50. http://dx.doi.org/10.1089/scd.2016.0309.

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12

Tsui, S., W. Dai, and L. Lu. "CCCTC-binding factor mediates effects of glucose on beta cell survival." Cell Proliferation 47, no. 1 (2013): 28–37. http://dx.doi.org/10.1111/cpr.12085.

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13

LI, T., and L. LU. "Functional role of CCCTC binding factor (CTCF) in stress-induced apoptosis." Experimental Cell Research 313, no. 14 (2007): 3057–65. http://dx.doi.org/10.1016/j.yexcr.2007.05.018.

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14

Yang, Bobae, Tae-Gyun Kim, Sueun Kim, and Hyoung-Pyo Kim. "CCCTC-binding factor regulates the development and function of dendritic cells." Journal of Immunology 202, no. 1_Supplement (2019): 118.5. http://dx.doi.org/10.4049/jimmunol.202.supp.118.5.

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Abstract Dendritic cells (DCs) are professional antigen presenting cells, which present antigen to cognate T cells. DC activation through diverse toll-like receptors is prerequisite for triggering efficient immune responses to foreign antigens. CCCTC-binding factor (CTCF) is a DNA binding protein that regulates 3D genome structure which is believed to be important to control of gene expression. Here we described that CTCF is required for development and function in DCs. CTCF is critically required for the FLT3L-dependent CD11c+ DCs (FL-DCs) development, unlike for those in the GM-CSF-dependent

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15

Taft, Ryan J., Peter G. Hawkins, John S. Mattick, and Kevin V. Morris. "The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localization." Epigenetics & Chromatin 4, no. 1 (2011): 13. http://dx.doi.org/10.1186/1756-8935-4-13.

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16

Kim, Somi, Nam-Kyung Yu, Kyu-Won Shim, et al. "Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF)." Journal of Neuroscience 38, no. 22 (2018): 5042–52. http://dx.doi.org/10.1523/jneurosci.2738-17.2018.

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17

Kim, Tae-Gyun, Mikyoung Kim, Jong-Joo Lee, et al. "CCCTC-binding factor controls the homeostatic maintenance and migration of Langerhans cells." Journal of Allergy and Clinical Immunology 136, no. 3 (2015): 713–24. http://dx.doi.org/10.1016/j.jaci.2015.03.033.

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18

Lu, Luo, Ling Wang, Tie Li та Jie Wang. "NF-κB Subtypes Regulate CCCTC Binding Factor Affecting Corneal Epithelial Cell Fate". Journal of Biological Chemistry 285, № 13 (2010): 9373–82. http://dx.doi.org/10.1074/jbc.m109.094425.

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19

Li, Tie, Zhenyu Lu, and Luo Lu. "Regulation of Eye Development by Transcription Control of CCCTC Binding Factor (CTCF)." Journal of Biological Chemistry 279, no. 26 (2004): 27575–83. http://dx.doi.org/10.1074/jbc.m313942200.

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20

Roy, Anna R., Abdalla Ahmed, Peter V. DiStefano, et al. "The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells." Journal of Biological Chemistry 293, no. 22 (2018): 8449–61. http://dx.doi.org/10.1074/jbc.m117.814699.

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21

Cannarella, Rossella, Andrea Crafa, Laura M. Mongioì, et al. "DNA Methylation in Offspring Conceived after Assisted Reproductive Techniques: A Systematic Review and Meta-Analysis." Journal of Clinical Medicine 11, no. 17 (2022): 5056. http://dx.doi.org/10.3390/jcm11175056.

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Background: In the last 40 years, assisted reproductive techniques (ARTs) have emerged as potentially resolving procedures for couple infertility. This study aims to evaluate whether ART is associated with epigenetic dysregulation in the offspring. Methods. To accomplish this, we collected all available data on methylation patterns in offspring conceived after ART and in spontaneously conceived (SC) offspring. Results. We extracted 949 records. Of these, 50 were considered eligible; 12 were included in the quantitative synthesis. Methylation levels of H19 CCCTC-binding factor 3 (CTCF3) were si

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22

Tang, Jyh-Bing, and Yee-Hsiung Chen. "Identification of a tyrosine-phosphorylated CCCTC-binding nuclear factor in capacitated mouse spermatozoa." PROTEOMICS 6, no. 17 (2006): 4800–4807. http://dx.doi.org/10.1002/pmic.200600256.

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23

Burcin, M., R. Arnold, M. Lutz, et al. "Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF." Molecular and Cellular Biology 17, no. 3 (1997): 1281–88. http://dx.doi.org/10.1128/mcb.17.3.1281.

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The transcriptional repressor negative protein 1 (NeP1) binds specifically to the F1 element of the chicken lysozyme gene silencer and mediates synergistic repression by v-ERBA, thyroid hormone receptor, or retinoic acid receptor. Another protein, CCCTC-binding factor (CTCF), specifically binds to 50-bp-long sequences that contain repetitive CCCTC elements in the vicinity of vertebrate c-myc genes. Previously cloned chicken, mouse, and human CTCF cDNAs encode a highly conserved 11-Zn-finger protein. Here, NeP1 was purified and DNA bases critical for NeP1-F1 interaction were determined. NeP1 is

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24

Li, Dapeng. "CCCTC-binding factor regulates splicing factor proline and glutamine-rich to promote malignant growth of osteosarcoma." American Journal of Translational Research 17, no. 2 (2025): 1495–509. https://doi.org/10.62347/stqk5435.

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25

Salamon, Daniel, Ferenc Banati, Anita Koroknai, et al. "Binding of CCCTC-binding factor in vivo to the region located between Rep* and the C promoter of Epstein–Barr virus is unaffected by CpG methylation and does not correlate with Cp activity." Journal of General Virology 90, no. 5 (2009): 1183–89. http://dx.doi.org/10.1099/vir.0.007344-0.

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In this study, the binding of the insulator protein CCCTC-binding factor (CTCF) to the region located between Rep* and the C promoter (Cp) of Epstein–Barr virus (EBV) was analysed using chromatin immunoprecipitation and in vivo footprinting. CTCF binding was found to be independent of Cp usage in cell lines corresponding to the major EBV latency types. Bisulfite sequencing and an electrophoretic mobility-shift assay (using methylated and unmethylated probes) revealed that CTCF binding was insufficient to induce local CpG demethylation in certain cell lines and was unaffected by CpG methylation

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26

Williams, Adam, and Richard A. Flavell. "The role of CTCF in regulating nuclear organization." Journal of Experimental Medicine 205, no. 4 (2008): 747–50. http://dx.doi.org/10.1084/jem.20080066.

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The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor (CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.

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27

Zhang, Yu, Jing Liang, Yanyan Li, et al. "CCCTC-binding Factor Acts Upstream of FOXA1 and Demarcates the Genomic Response to Estrogen." Journal of Biological Chemistry 285, no. 37 (2010): 28604–13. http://dx.doi.org/10.1074/jbc.m110.149658.

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28

Wang, Feng, Zhongqiong Tang, Honglian Shao, et al. "Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression." Biochemical and Biophysical Research Communications 500, no. 4 (2018): 852–59. http://dx.doi.org/10.1016/j.bbrc.2018.04.173.

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29

Höflmayer, Doris, Amélie Steinhoff, Claudia Hube‐Magg, et al. "Expression of CCCTC‐binding factor (CTCF) is linked to poor prognosis in prostate cancer." Molecular Oncology 14, no. 1 (2019): 129–38. http://dx.doi.org/10.1002/1878-0261.12597.

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30

Zhang, He, Beibei Niu, Ji-Fan Hu, et al. "Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II." Journal of Cell Biology 193, no. 3 (2011): 475–87. http://dx.doi.org/10.1083/jcb.201101021.

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Monoallelic expression of IGF2 is regulated by CCCTC binding factor (CTCF) binding to the imprinting control region (ICR) on the maternal allele, with subsequent formation of an intrachromosomal loop to the promoter region. The N-terminal domain of CTCF interacts with SUZ12, part of the polycomb repressive complex-2 (PRC2), to silence the maternal allele. We synthesized decoy CTCF proteins, fusing the CTCF deoxyribonucleic acid–binding zinc finger domain to CpG methyltransferase Sss1 or to enhanced green fluorescent protein. In normal human fibroblasts and breast cancer MCF7 cell lines, the CT

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31

Braccioli, Luca, and Elzo de Wit. "CTCF: a Swiss-army knife for genome organization and transcription regulation." Essays in Biochemistry 63, no. 1 (2019): 157–65. http://dx.doi.org/10.1042/ebc20180069.

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Abstract Orchestrating vertebrate genomes require a complex interplay between the linear composition of the genome and its 3D organization inside the nucleus. This requires the function of specialized proteins, able to tune various aspects of genome organization and gene regulation. The CCCTC-binding factor (CTCF) is a DNA binding factor capable of regulating not only the 3D genome organization, but also key aspects of gene expression, including transcription activation and repression, RNA splicing, and enhancer/promoter insulation. A growing body of evidence proposes that CTCF, together with

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32

Herblot, Sabine, Patricia Chastagner, Laila Samady, et al. "IL-2-Dependent Expression of Genes Involved in Cytoskeleton Organization, Oncogene Regulation, and Transcriptional Control." Journal of Immunology 162, no. 6 (1999): 3280–88. http://dx.doi.org/10.4049/jimmunol.162.6.3280.

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Abstract IL-2 induces growth, differentiation, and/or apoptosis of lymphoid cells. To study further the molecular basis of IL-2 function, we used a cDNA subtraction approach involving a cell line grown in IL-2 or IL-4. From the corresponding library, 66 nonredundant sequences were characterized; 16 of them encode identified proteins. The kinetics of in vitro expression of 8 selected sequences, the functions of which could be associated with IL-2-induced T cell activation/differentiation, was investigated using an IL-2-dependent T cell line. IL-2 increased the expression of cytoskeleton protein

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33

Erdos, Edina, Katalin Sandor, Crystal L. Young-Erdos, et al. "Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women." Cells 13, no. 1 (2023): 86. http://dx.doi.org/10.3390/cells13010086.

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Determining the mechanism driving body fat distribution will provide insights into obesity-related health risks. We used functional genomics tools to profile the epigenomic landscape to help infer the differential transcriptional potential of apple- and pear-shaped women’s subcutaneous adipose-derived stem cells (ADSCs). We found that CCCTC-binding factor (CTCF) expression and its chromatin binding were increased in ADSCs from pear donors compared to those from apple donors. Interestingly, the pear enriched CTCF binding sites were located predominantly at the active transcription start sites (

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34

Zhang, Han, Lin Zhu, Huacheng He, et al. "NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia." Molecular Cancer 13, no. 1 (2014): 5. http://dx.doi.org/10.1186/1476-4598-13-5.

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35

Paredes, Sur Herrera, Michael F. Melgar, and Praveen Sethupathy. "Promoter-proximal CCCTC-factor binding is associated with an increase in the transcriptional pausing index." Bioinformatics 29, no. 12 (2012): 1485–87. http://dx.doi.org/10.1093/bioinformatics/bts596.

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36

Wang, Jie, Yumei Wang, and Luo Lu. "De-SUMOylation of CCCTC Binding Factor (CTCF) in Hypoxic Stress-induced Human Corneal Epithelial Cells." Journal of Biological Chemistry 287, no. 15 (2012): 12469–79. http://dx.doi.org/10.1074/jbc.m111.286641.

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Epigenetic factor CCCTC binding factor (CTCF) plays important roles in the genetic control of cell fate. Previous studies found that CTCF is positively and negatively regulated at the transcriptional level by epidermal growth factor (EGF) and ultraviolet (UV) stimulation, respectively. However, it is unknown whether other stresses modify the CTCF protein. Here, we report that regulation of CTCF by de-SUMOylation is dependent upon hypoxic and oxidative stresses. We found that stimulation of human corneal epithelial cells with hypoxic stress suppressed a high molecular mass form of CTCF (150 kDa

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37

Wang, Rong, Jingjing Shen, Peitang Huang, and Xudong Zhu. "CCCTC-binding factor controls its own nuclear transport via regulating the expression of importin 13." Molecules and Cells 35, no. 5 (2013): 388–95. http://dx.doi.org/10.1007/s10059-013-2283-z.

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38

Wu, Yonghu, Zhilian Jia, Xiao Ge та Qiang Wu. "Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus". Science China Life Sciences 63, № 6 (2020): 835–44. http://dx.doi.org/10.1007/s11427-019-1598-4.

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39

Wu, Jie, Peng-Chang Li, Jun-Yi Pang, et al. "CCCTC-binding factor inhibits breast cancer cell proliferation and metastasis via inactivation of the nuclear factor-kappaB pathway." Oncotarget 8, no. 55 (2017): 93516–29. http://dx.doi.org/10.18632/oncotarget.18977.

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40

Wang, Ling, Xiaolin Wu, Ting Shi та Luo Lu. "Epidermal Growth Factor (EGF)-induced Corneal Epithelial Wound Healing through Nuclear Factor κB Subtype-regulated CCCTC Binding Factor (CTCF) Activation". Journal of Biological Chemistry 288, № 34 (2013): 24363–71. http://dx.doi.org/10.1074/jbc.m113.458141.

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41

Renda, Mario, Ilaria Baglivo, Bonnie Burgess-Beusse, et al. "Critical DNA Binding Interactions of the Insulator Protein CTCF." Journal of Biological Chemistry 282, no. 46 (2007): 33336–45. http://dx.doi.org/10.1074/jbc.m706213200.

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The DNA-binding protein CTCF (CCCTC binding factor) mediates enhancer blocking insulation at sites throughout the genome and plays an important role in regulating allele-specific expression at the Igf2/H19 locus and at other imprinted loci. Evidence is also accumulating that CTCF is involved in large scale organization of genomic chromatin. Although CTCF has 11 zinc fingers, we show here that only 4 of these are essential to strong binding and that they recognize a core 12-bp DNA sequence common to most CTCF sites. By deleting individual fingers and mutating individual sites, we determined the

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42

Lee, Sun Hee, Kyoung-Dong Kim, Miyeon Cho, et al. "Characterization of a new CCCTC-binding factor binding site as a dual regulator of Epstein-Barr virus latent infection." PLOS Pathogens 19, no. 1 (2023): e1011078. http://dx.doi.org/10.1371/journal.ppat.1011078.

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Distinct viral gene expression characterizes Epstein-Barr virus (EBV) infection in EBV-producing marmoset B-cell (B95-8) and EBV-associated gastric carcinoma (SNU719) cell lines. CCCTC-binding factor (CTCF) is a structural chromatin factor that coordinates chromatin interactions in the EBV genome. Chromatin immunoprecipitation followed by sequencing against CTCF revealed 16 CTCF binding sites in the B95-8 and SNU719 EBV genomes. The biological function of one CTCF binding site (S13 locus) located on the BamHI A right transcript (BART) miRNA promoter was elucidated experimentally. Microscale th

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43

Boftsi, Maria, Kinjal Majumder, Lisa R. Burger, and David J. Pintel. "Binding of CCCTC-Binding Factor (CTCF) to the Minute Virus of Mice Genome Is Important for Proper Processing of Viral P4-Generated Pre-mRNAs." Viruses 12, no. 12 (2020): 1368. http://dx.doi.org/10.3390/v12121368.

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Specific chromatin immunoprecipitation of salt-fractionated infected cell extracts has demonstrated that the CCCTC-binding factor (CTCF), a highly conserved, 11-zinc-finger DNA-binding protein with known roles in cellular and viral genome organization and gene expression, specifically binds the genome of Minute Virus of Mice (MVM). Mutations that diminish binding of CTCF to MVM affect processing of the P4-generated pre-mRNAs. These RNAs are spliced less efficiently to generate the R1 mRNA, and definition of the NS2-specific exon upstream of the small intron is reduced, leading to relatively le

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44

Bergström, Rosita, Katia Savary, Anita Morén та ін. "Transforming Growth Factor β Promotes Complexes between Smad Proteins and the CCCTC-binding Factor on theH19Imprinting Control Region Chromatin". Journal of Biological Chemistry 285, № 26 (2010): 19727–37. http://dx.doi.org/10.1074/jbc.m109.088385.

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45

Fu, Vivian X., Steven R. Schwarze, Michelle L. Kenowski, Scott LeBlanc, John Svaren, and David F. Jarrard. "A Loss of Insulin-like Growth Factor-2 Imprinting Is Modulated by CCCTC-binding Factor Down-regulation at Senescence in Human Epithelial Cells." Journal of Biological Chemistry 279, no. 50 (2004): 52218–26. http://dx.doi.org/10.1074/jbc.m405015200.

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The imprinted insulin-like growth factor-2 (IGF2) gene is an auto/paracrine growth factor expressed only from the paternal allele in adult tissues. In tissues susceptible to aging-related cancers, including the prostate, a relaxation ofIGF2imprinting is found, suggesting a permissive role for epigenetic alterations in cancer development. To determine whetherIGF2imprinting is altered in cellular aging and senescence, human prostate epithelial and urothelial cells were passaged serially in culture to senescence. Allelic analyses using anIGF2polymorphism demonstrated a complete conversion of theI

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46

Ribeiro de Almeida, Claudia, Helen Heath, Sanja Krpic, et al. "Critical Role for the Transcription Regulator CCCTC-Binding Factor in the Control of Th2 Cytokine Expression." Journal of Immunology 182, no. 2 (2009): 999–1010. http://dx.doi.org/10.4049/jimmunol.182.2.999.

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47

Kim, Tae-Gyun, Sueun Kim, Soyeon Jung, et al. "CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice." Experimental & Molecular Medicine 49, no. 8 (2017): e371-e371. http://dx.doi.org/10.1038/emm.2017.124.

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48

Chang, J., B. Zhang, H. Heath, N. Galjart, X. Wang, and J. Milbrandt. "Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus." Proceedings of the National Academy of Sciences 107, no. 50 (2010): 21836–41. http://dx.doi.org/10.1073/pnas.1002130107.

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49

Borkowska, Joanna, Anna Domaszewska-Szostek, Paulina Kołodziej, et al. "Alterations in 5hmC level and genomic distribution in aging-related epigenetic drift in human adipose stem cells." Epigenomics 12, no. 5 (2020): 423–37. http://dx.doi.org/10.2217/epi-2019-0131.

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Aim: To clarify mechanisms affecting the level and distribution of 5-hydroxymethylcytosine (5hmC) during aging. Materials & methods: We examined levels and genomic distribution of 5hmC along with the expression of ten–eleven translocation methylcytosine dioxygenases (TETs) in adipose stem cells in young and age-advanced individuals. Results: 5hmC levels were higher in adipose stem cells of age-advanced than young individuals (p = 0.0003), but were not associated with age-related changes in expression of TETs. 5hmC levels correlated with population doubling time (r = 0.62; p = 0.01). We ide

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50

Bintu, Bogdan, Leslie J. Mateo, Jun-Han Su, et al. "Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells." Science 362, no. 6413 (2018): eaau1783. http://dx.doi.org/10.1126/science.aau1783.

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The spatial organization of chromatin is pivotal for regulating genome functions. We report an imaging method for tracing chromatin organization with kilobase- and nanometer-scale resolution, unveiling chromatin conformation across topologically associating domains (TADs) in thousands of individual cells. Our imaging data revealed TAD-like structures with globular conformation and sharp domain boundaries in single cells. The boundaries varied from cell to cell, occurring with nonzero probabilities at all genomic positions but preferentially at CCCTC-binding factor (CTCF)- and cohesin-binding s

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