Log in

Relevant bibliographies by topics / CCl4-induced hepatic injury / Journal articles

To see the other types of publications on this topic, follow the link: CCl4-induced hepatic injury.

Journal articles on the topic 'CCl4-induced hepatic injury'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'CCl4-induced hepatic injury.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Cui, Ming-Xia, Jun-Feng Jiang, Guang-Ning Min, Wei Han, and Yong-Jie Wu. "Ciliary neurotrophic factor analogue aggravates CCl4-induced acute hepatic injury in rats." Canadian Journal of Physiology and Pharmacology 95, no. 5 (2017): 620–23. http://dx.doi.org/10.1139/cjpp-2016-0564.

Full text

Abstract:

Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate hepatic steatosis and injury induced by carbon tetrachloride (CCl4). Unexpectedly, when combined with CCl4, CNTF aggravated hepatic steatosis and liver injury. The mechanism is associated with effects of CNTF that inhibited lipoprotein secretion and drastically impaired the ability

APA, Harvard, Vancouver, ISO, and other styles

2

Nakade, Yukiomi, Masashi Yoneda, Kimihide Nakamura, Isao Makino, and Akira Terano. "Involvement of endogenous CRF in carbon tetrachloride-induced acute liver injury in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 282, no. 6 (2002): R1782—R1788. http://dx.doi.org/10.1152/ajpregu.00514.2001.

Full text

Abstract:

Central neuropeptides play important roles in many physiological and pathophysiological regulation mediated through the autonomic nervous system. In regard to the hepatobiliary system, several neuropeptides act in the brain to regulate bile secretion, hepatic blood flow, and hepatic proliferation. Central injection of corticotropin-releasing factor (CRF) aggravates carbon tetrachloride (CCl4)-induced acute liver injury through the sympathetic nervous pathway in rats. However, still nothing is known about a role of endogenous neuropeptides in the brain in hepatic pathophysiological regulations.

APA, Harvard, Vancouver, ISO, and other styles

3

Xiong, Rui, Shuzhong Shan, Xiaoming Wang, et al. "Aloperine attenuates carbon tetrachloride-induced mouse hepatic injury via Nrf2/HO-1 pathway." Tropical Journal of Pharmaceutical Research 19, no. 5 (2020): 983–88. http://dx.doi.org/10.4314/tjpr.v19i5.11.

Full text

Abstract:

Purpose: To investigate whether aloperine pretreatment ameliorates acute liver injury in carbon tetrachloride (CCl4)-treated mice.Methods: Mice were injected with CCl4 and orally administered aloperine. Blood samples and liver tissues were used for histopathological and biochemical analyses, respectively. Protein expression levels were determined by western blotting.Results: Histopathological analysis indicate that aloperine pretreatment significantly alleviated CCl4- induced mouse hepatic injury. CCl4 treatment induced the upregulation of aspartate aminotransferase (AST), alkaline phosphatase

APA, Harvard, Vancouver, ISO, and other styles

4

Yokohama, Shiro, Masashi Yoneda, Kimihide Nakamura, and Isao Makino. "Effect of central corticotropin-releasing factor on carbon tetrachloride-induced acute liver injury in rats." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 3 (1999): G622—G628. http://dx.doi.org/10.1152/ajpgi.1999.276.3.g622.

Full text

Abstract:

Central neuropeptides play important roles in many instances of physiological and pathophysiological regulation mediated through the autonomic nervous system. In regard to the hepatobiliary system, several neuropeptides act in the brain to regulate bile secretion, hepatic blood flow, and hepatic proliferation. Stressors and sympathetic nerve activation are reported to exacerbate experimental liver injury. Some stressors are known to stimulate corticotropin-releasing factor (CRF) synthesis in the central nervous system and induce activation of sympathetic nerves in animal models. The effect of

APA, Harvard, Vancouver, ISO, and other styles

5

Dorsaf, Hallegue, Moujahed Sabrine, Ben Lamine Houda, Ben Rhouma Khémais, Sakly Mohsen, and Tebourbi Olfa. "Pecan pericarp extract protects against carbon tetrachloride-induced liver injury through oxidative mechanism in rats." Toxicology Research 9, no. 5 (2020): 652–60. http://dx.doi.org/10.1093/toxres/tfaa071.

Full text

Abstract:

Abstract The purpose of this study was to quantify the proanthocyanidin content of pecan (Carya illinoinensis) pericarp extract (PPE) and to assess its useful impacts against carbon tetrachloride (CCl4)-induced hepatotoxicity. Rats were randomly divided into four groups: Group 1: received intraperitoneal injection of saline solution, Group 2: was injected with PPE (25 mg/kg body weight) for 10 consecutive days, Group 3: received CCl4 (0.5 ml/kg, subcutaneous injection), Group 4: was coadministred with PPE + CCl4. The CCl4 was administered every 3 days during 10 days. Results revealed the prese

APA, Harvard, Vancouver, ISO, and other styles

6

Hsieh, Po-Chow, Yu-Ling Ho, Guan-Jhong Huang, et al. "Hepatoprotective Effect of the Aqueous Extract of Flemingia macrophylla on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats Through Anti-Oxidative Activities." American Journal of Chinese Medicine 39, no. 02 (2011): 349–65. http://dx.doi.org/10.1142/s0192415x11008877.

Full text

Abstract:

This study investigated the protective effect of the aqueous extract of Flemingia macrophylla (AFM) against hepatic injury induced by CCl4. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarkers in the blood to indicate hepatic injury. Product of lipid peroxidation (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury. Moreover, histopathological observation was assayed for the degree of hepatic injury. After oral administration of

APA, Harvard, Vancouver, ISO, and other styles

7

Mori, Mutsuki, Takeshi Izawa, Yohei Inai, et al. "Dietary Iron Overload Differentially Modulates Chemically-Induced Liver Injury in Rats." Nutrients 12, no. 9 (2020): 2784. http://dx.doi.org/10.3390/nu12092784.

Full text

Abstract:

Hepatic iron overload is well known as an important risk factor for progression of liver diseases; however, it is unknown whether it can alter the susceptibility to drug-induced hepatotoxicity. Here we investigate the pathological roles of iron overload in two single-dose models of chemically-induced liver injury. Rats were fed a high-iron (Fe) or standard diet (Cont) for four weeks and were then administered with allyl alcohol (AA) or carbon tetrachloride (CCl4). Twenty-four hours after administration mild mononuclear cell infiltration was seen in the periportal/portal area (Zone 1) in Cont-A

APA, Harvard, Vancouver, ISO, and other styles

8

Berlanga, J., M. E. Caballero, D. Ramirez, et al. "Rapid Communication: Epidermal Growth Factor Protects against Carbon Tetrachloride-Induced Hepatic Injury." Clinical Science 94, no. 3 (1998): 219–23. http://dx.doi.org/10.1042/cs0940219.

Full text

Abstract:

1. Epidermal growth factor (EGF) is known to protect the gastrointestinal tract against various noxious agents. Its potential value in preventing/treating hepatic injury is, however, largely unexplored. We therefore examined whether EGF could influence CCl4-induced hepatic injury. 2. Female Sprague—Dawley rats (8 per group) received saline or recombinant EGF (500 or 750 μg/kg, intraperitoneal) 30 min before CCU (20% v/v, in olive oil, intraperitoneal). Eighteen hours later, animals were killed, serum was collected for assay of biochemical markers of hepatic injury and livers were removed for h

APA, Harvard, Vancouver, ISO, and other styles

9

Lai, Tung-Yuan, Yueh-Wern Wu, Jaung-Geng Lin та Wen-Chuan Lin. "Effect of Pretreatment of Rats with an Urinary Preparation on Liver Injuries Induced by Carbon Tetrachloride and α-Naphthylisothiocyanate". American Journal of Chinese Medicine 26, № 03n04 (1998): 343–51. http://dx.doi.org/10.1142/s0192415x98000385.

Full text

Abstract:

The effect of oral administration of a preparation of human urine (PHU) on the progression of acute liver injury was examined in rats intoxicated with carbon tetrachloride (CCl4) and α-naphthylisothiocyanate (ANIT). PHU protected the liver from CCl4-induced injury as judged by morphological and biochemical observations. In contrast, PHU aggravated ANIT-induced injury as judged also by morphological and biochemical observation. PHU prevented the increase in hepatic glutathione (GSH) and lipid peroxidation induced by CCl4. But PHU enhanced the increase in hepatic GSH caused by ANIT. These result

APA, Harvard, Vancouver, ISO, and other styles

10

Jeong, Tae Bin, Doyoung Kwon, Seung Won Son, et al. "Weaning Mice and Adult Mice Exhibit Differential Carbon Tetrachloride-Induced Acute Hepatotoxicity." Antioxidants 9, no. 3 (2020): 201. http://dx.doi.org/10.3390/antiox9030201.

Full text

Abstract:

Age is a risk factor for drug-induced liver injury (DILI). However, there is a limited understanding of pediatric DILI. Here, 2-week-old weaning and 8-week-old adult male ICR mice were intraperitoneally injected with CCl4 (0.1 mmol/kg equal to 15.4 mg/kg) to comparatively evaluate the time-dependent liver damage and cellular events. CCl4 significantly enhanced the serum alanine aminotransferase/aspartate aminotransferase levels and hepatic centrilobular necrosis in the weaning mice, whereas it induced mild liver injury in the adult mice. CCl4-treated weaning mice exhibited higher hepatic level

APA, Harvard, Vancouver, ISO, and other styles

11

Zhu, Xiao Hua, and Lu Jiang. "Biological Effect of Exo-Polysaccharides Produced by Grifola frondosa on Carbon Tetrachloride Induced Liver Injury In Vitro." Advanced Materials Research 893 (February 2014): 496–99. http://dx.doi.org/10.4028/www.scientific.net/amr.893.496.

Full text

Abstract:

This paper studied the biological effect in vitro of exo-polysaccharides from Grifola frondosa (GFP) on liver injury induced by CCL4, Three different molecular weight of GFP were obtained by ultrafiltration, that were GFP-1 GFP-2 and GFP-3. The result of liver injury induced by CCL4 through detecting the cell survival rate and AST, ALT activity indicated that GFP-2 had much better protective in vitro with acute hepatic injury induced by CCL4.

APA, Harvard, Vancouver, ISO, and other styles

12

Choi, Min-Koo, Im-Sook Song, Dae-Duk Kim, Suk-Jae Chung, and Chang-Koo Shim. "Altered Pharmacokinetics of Daunorubicin in Rats with CCl4-Induced Hepatic Injury." Journal of Pharmacy & Pharmaceutical Sciences 10, no. 4 (2007): 443. http://dx.doi.org/10.18433/j3mw28.

Full text

Abstract:

PURPOSE. The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug. METHODS. CCl4-EHI was induced in rats by a single intraperitoneal injection of CCl4 (1mL/kg rat), and a 24 h fasting period. Daunorubicin was administered intravenously to control and EHI rats at a dose of 11.3 mg/mL/kg and the in vivo pharmacokinetics was studied. The in vitro uptake of the drug into isolated hepatocytes and canal

APA, Harvard, Vancouver, ISO, and other styles

13

Chen, Mei-Fen, Hsien-Hui Chung, and Han-Lin Lu. "Protection of the Extracts ofLentinus edodesMycelia against Carbon-Tetrachloride-Induced Hepatic Injury in Rats." Scientific World Journal 2012 (2012): 1–8. http://dx.doi.org/10.1100/2012/231586.

Full text

Abstract:

Lentinus edodesis the medicinal macrofungus showing potential for therapeutic applications in infectious disorders including hepatitis. In an attempt to develop the agent for handling hepatic injury, we used the extracts ofLentinus edodesmycelia (LEM) to screen the effect on hepatic injury in rats induced by carbon tetrachloride (CCl4). Intraperitoneal administration of CCl4not only increased plasma glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) but also decreased hepatic superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in rats. Similar to the

APA, Harvard, Vancouver, ISO, and other styles

14

Khoo, C., N. A. Hallquist, D. A. Samuelson, and R. J. Cousins. "Differential expression of cysteine-rich intestinal protein in liver and intestine in CCl4-induced inflammation." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 4 (1996): G613—G618. http://dx.doi.org/10.1152/ajpgi.1996.270.4.g613.

Full text

Abstract:

Cysteine-rich intestinal protein (CRIP) is a double zinc finger (LIM domain) protein that is developmentally regulated but has an unknown function. CRIP is highly expressed in the intestine, but expression is low in liver. To determine if CRIP expression is regulated under altered physiological status, we used CCl4-induced injury as a model to produce hepatic injury and systemic effects associated with inflammation. Since CRIP is a zinc finger protein and zinc decreases the hepatic response to CCl4, the effect of supplemental dietary zinc (300 mg/kg diet) was also examined. Our results show th

APA, Harvard, Vancouver, ISO, and other styles

15

DEULOFEU, Ramón, Albert PARÉS, Mireia RUBIO, et al. "S-Adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats." Clinical Science 99, no. 4 (2000): 315–20. http://dx.doi.org/10.1042/cs0990315.

Full text

Abstract:

In various experimental models, S-adenosylmethionine (SAMe) has been shown to reduce liver injury by preventing depletion of glutathione, one of the antioxidant systems that plays a critical role in defence against oxidative stress. On the other hand, α-tocopherol may be decreased in liver diseases, and treatment with this vitamin reduces liver injury in CCl4-treated rats. Since there is a close relationship among the different antioxidant systems (mainly glutathione, α-tocopherol and ascorbic acid), we have assessed whether, as well as restoring hepatic glutathione content, SAMe has any effec

APA, Harvard, Vancouver, ISO, and other styles

16

Rahman, A., SM Vasenwala, and M. Iqbal. "Hepatoprotective potential of glyceryl trinitrate against chemically induced oxidative stress and hepatic injury in rats." Human & Experimental Toxicology 36, no. 8 (2016): 785–94. http://dx.doi.org/10.1177/0960327116665675.

Full text

Abstract:

Glyceryl trinitrate (GTN) has been used widely as a potent vasodilator to treat heart conditions, such as angina pectoris and chronic heart failure. This study aims to elucidate the effect of exogenous nitric oxide (NO) administration, using GTN, on carbon tetrachloride (CCl4)-induced oxidative stress and liver injury in rats. The results obtained demonstrated that NO generated by the administration of GTN affords protection against CCl4-induced oxidative stress and liver injury. Administration of CCl4 resulted in a significant ( p < 0.001) increase in lipid peroxidation and tissue damage m

APA, Harvard, Vancouver, ISO, and other styles

17

Lu, Na, Yun Liu, An Tang, Lulu Chen, Dengshun Miao та Xiaoqin Yuan. "Hepatocyte-Specific Ablation of PP2A Catalytic SubunitαAttenuates Liver Fibrosis Progression via TGF-β1/Smad Signaling". BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/794862.

Full text

Abstract:

Protein phosphatase 2A (PP2A), a family of the major serine/threonine phosphatases in cells, regulates many aspects of physiological processes. However, isoform-specific substrates and the biological role of each specific member of the PP2A family remain largely unknown. In this study, we investigated whether PP2A catalytic subunit Cα(PP2Acα) is involved in chronic hepatic injury and fibrosis. A hepatocyte-specific PP2Acαablation mice model was established to examine the effect of PP2Acαon carbon tetrachloride- (CCl4-) induced chronic hepatic injury and fibrosis. Our results showed that PP2Acα

APA, Harvard, Vancouver, ISO, and other styles

18

Liao, Jung-Chun, Kun-Hung Lin, Hao-Yuan Cheng, Jin-Bin Wu, Ming-Tsuen Hsieh, and Wen-Huang Peng. "Actinidia rubricaulisAttenuates Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats." American Journal of Chinese Medicine 35, no. 01 (2007): 81–88. http://dx.doi.org/10.1142/s0192415x07004643.

Full text

Abstract:

The purpose of this study was to evaluate the antioxidant activity and hepatoprotective effect of ethanol extracts of Actinidia rubricaulis (AR) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received AR throughout the entire experimental period. AR reduced the elevated levels of serum glutamate-oxalate-transaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) caused by CCl4at weeks 1,3,6, and 8. The biochemical data were consistent with those of the histological observations. The AR extract re

APA, Harvard, Vancouver, ISO, and other styles

19

Ebaid, Hossam, Jameel Al-Tamimi, Iftekhar Hassan, et al. "Effect of Selenium Nanoparticles on Carbon Tetrachloride-Induced Hepatotoxicity in the Swiss Albino Rats." Applied Sciences 11, no. 7 (2021): 3044. http://dx.doi.org/10.3390/app11073044.

Full text

Abstract:

Background: This study investigated selenium nanoparticles’ protective effects (SE-NPs) against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Methods: Rats were divided into four groups (n = 8). Group 1 rats received the vehicle solution only. Group 2 received a single intraperitoneal injection of 1 mL/kg CCl4 in liquid paraffin (1:1 v/v). Group 3 was treated with SE-NPs (2.5 mg/kg) twice a week for three weeks before receiving CCl4 challenge. Oxidative stress, liver function, liver histopathology and serum lipid levels were evaluated. Results: Plasma concentrations of aspartate

APA, Harvard, Vancouver, ISO, and other styles

20

Li, Shulan, Juan Liu, Mengya Zhang, Yuan Chen, Tianxing Zhu, and Jun Wang. "Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice." Marine Drugs 16, no. 9 (2018): 300. http://dx.doi.org/10.3390/md16090300.

Full text

Abstract:

Several in vitro studies have shown the potential hepatoprotective properties of eckol, a natural phlorotannin derived from the brown alga. However, the in vivo hepatoprotective potential of eckol has not been determined. In this study, we performed an in vivo study to investigate the protective effect of eckol and its possible mechanisms on the carbon tetrachloride (CCl4)-induced acute liver injury model in mice. Results revealed that eckol pre-treatment at the dose of 0.5 and 1.0 mg/kg/day for 7 days significantly suppressed the CCl4-induced increases of alanine transaminase (ALT) and aspart

APA, Harvard, Vancouver, ISO, and other styles

21

Alqasoumi, Saleh. "Carbon Tetrachloride-Induced Hepatotoxicity: Protective Effect of 'Rocket' Eruca sativa L. in Rats." American Journal of Chinese Medicine 38, no. 01 (2010): 75–88. http://dx.doi.org/10.1142/s0192415x10007671.

Full text

Abstract:

The hepatoprotective and antioxidant effect of an ethanolic extract of 'Rocket' Eruca sativa L. (EER), on liver injury induced by carbon tetrachloride ( CCl4 ) was investigated. Wistar albino rats were administered 250 and 500 mg/kg body weight extract orally for 10 consecutive days. Marker enzymes GOT, GPT, ALP, GGT and bilirubin were estimated in serum. Whereas, non-protein sulfhydryl (NP-SH), total protein (TP) and malondialdehyde (MDA) were estimated in liver tissue as markers for oxidative stress. Histopathological assessment was also done on liver tissue. CCl4 induced liver poisoning in

APA, Harvard, Vancouver, ISO, and other styles

22

Wu, Tao, Jingjing Li, Yong Li, and Hongping Song. "Antioxidant and Hepatoprotective Effect of Swertiamarin on Carbon Tetrachloride-Induced Hepatotoxicity via the Nrf2/HO-1 Pathway." Cellular Physiology and Biochemistry 41, no. 6 (2017): 2242–54. http://dx.doi.org/10.1159/000475639.

Full text

Abstract:

Background/Aims: Swertiamarin (STM), the main bioactive component in Swertia mussotii Franch (Gentianaceae), has been shown to exert hepatoprotective effects on experimental liver injury. However, the effects and exact mechanisms of STM on carbon tetrachloride (CCl4) causing hepatotoxicity are still unknown. This study investigated the potential protective effects and mechanisms of STM on CCl4-induced liver injury in rats. Methods: Adult male Sprague-Dawley (SD) rats were exposed to CCl4 with or without STM co-administration for consecutive eight weeks. Results: STM significantly ameliorated C

APA, Harvard, Vancouver, ISO, and other styles

23

Hsieh, Yun-Cheng, Kuei-Chuan Lee, Pei-Shan Wu, et al. "Eritoran Attenuates Hepatic Inflammation and Fibrosis in Mice with Chronic Liver Injury." Cells 10, no. 6 (2021): 1562. http://dx.doi.org/10.3390/cells10061562.

Full text

Abstract:

Toll-like receptor 4 (TLR4) signaling plays a key role in liver inflammation and fibrosis. The therapeutic effects of eritoran, a TLR4 antagonist, in mice with chronic liver injury remained unclear. C57BL/6 mice were fed a fast-food diet (FFD) or treated with carbon tetrachloride (CCl4) to induce chronic liver injury. Eritoran (10 mg/kg) or a vehicle was randomly intraperitoneally administered to the FFD-fed mice and the CCl4-injured mice. Primary mouse liver cells were cultured with lipopolysaccharide (LPS) or eritoran. In both FFD and CCl4 mouse models, eritoran significantly reduced serum A

APA, Harvard, Vancouver, ISO, and other styles

24

Lai, Tung-Yuan, Yueh-Wern Wu, and Wen-Chuan Lin. "Effect of a Urinary Preparation on Liver Injury by Short-term Carbon Tetrachloride Treatment in Rats." American Journal of Chinese Medicine 27, no. 02 (1999): 241–50. http://dx.doi.org/10.1142/s0192415x99000276.

Full text

Abstract:

The hepatoprotective effect of a preparation of human urine (PHU) was assessed against short-term carbon tetrachloride (CCl4) treatment in rats. Significant prevention of liver injury by PHU was found after CCl4 treatment, judging by the changes of serum biochemical parameters, and hepatic protein and triglyceride contents. The increased liver lipid peroxidation, and decreased liver vitamin C concentrations observed after CCl4 treatment were significantly prevented by PHU administration. The increase in liver glutathione (GSH) contents observed after CCl4 treatment was further increased by PHU

APA, Harvard, Vancouver, ISO, and other styles

25

Islam, A. M. T., M. A. U. Chowdhury, M. E. Uddin, et al. "Protective Effect of Alpina nigra Leaves Extract in Mouse Liver Injury Induced by Carbon Tetrachloride." Journal of Scientific Research 8, no. 3 (2016): 381–86. http://dx.doi.org/10.3329/jsr.v8i3.26842.

Full text

Abstract:

The present study was aimed to evaluate the hepatoprotective activity of methanol extract against carbon tetrachloride (CCl4) induced hepatic damage in rats. CCl4 caused liver damage in rats manifested by significant rise in serum enzyme levels. To examine the effect of the extract male albino rats were used and extract was administered orally at a dose of 300 mg/kg once daily. The results obtained showed that there were reductions in the activities of serum SGOT, SGPT, ALP, total protein, total bilirubin from 97.67±1.78, 275.67±2.86, 934 ± 1.41, 1.13±0.227 and 7.50±0.707 in animals treated wi

APA, Harvard, Vancouver, ISO, and other styles

26

Wu, Shu-Ju, Ka-Wai Tam, Ya-Hui Tsai, Chun-Chao Chang, and Jane C. J. Chao. "Curcumin and Saikosaponin A Inhibit Chemical-Induced Liver Inflammation and Fibrosis in Rats." American Journal of Chinese Medicine 38, no. 01 (2010): 99–111. http://dx.doi.org/10.1142/s0192415x10007695.

Full text

Abstract:

Curcumin and saikosaponin A as antioxidants improve antioxidant status. This study investigated the anti-inflammatory and antifibrotic actions of curcumin and saikosaponin A on CCl4 -induced liver damage. Sprague-Dawley rats were randomly divided into control, CCl4 , CCl4+ curcumin (0.005%; CU), CCl4 + saikosaponin A (0.004%; SS), and CCl4 + curcumin + saikosaponin A (0.005% + 0.004%; CU + SS) groups. Carbon tetrachloride (40% in olive oil) at a dose of 0.75 ml/kg was injected intraperitoneally once a week. Curcumin and saikosaponin A were supplemented alone or in combination with diet 1 week

APA, Harvard, Vancouver, ISO, and other styles

27

Yamaguchi, Yusuke, Yushi Hirata, Takeshi Saito, and Hitomi Kumagai. "Combined Effects of Amino Acids in Garlic and Buna-Shimeji (Hypsizygus marmoreus) on Suppression of CCl4-Induced Hepatic Injury in Rats." Foods 10, no. 7 (2021): 1491. http://dx.doi.org/10.3390/foods10071491.

Full text

Abstract:

The combination of the garlic-derived amino acid, S-allyl-l-cysteine sulfoxide (ACSO), and ornithine or arginine on CCl4-induced hepatic injury was examined. After investigating the effectiveness of the mixture of ACSO and ornithine or arginine in preventing hepatic injury in vivo, an extract rich in ACSO and ornithine was prepared by converting arginine in garlic to ornithine by arginase from Hypsizygus marmoreus (buna-shimeji), after screening the productivity of ornithine among 12 kinds of mushrooms. Co-administration of ACSO with ornithine or arginine suppressed the increase in aspartate t

APA, Harvard, Vancouver, ISO, and other styles

28

Tsai, Jen-Chieh, Yi-An Chen, Jung-Tsung Wu, et al. "Extracts from Fermented Black Garlic Exhibit a Hepatoprotective Effect on Acute Hepatic Injury." Molecules 24, no. 6 (2019): 1112. http://dx.doi.org/10.3390/molecules24061112.

Full text

Abstract:

The mechanism of hepatoprotective compounds is usually related to its antioxidant or anti-inflammatory effects. Black garlic is produced from garlic by heat treatment and its anti-inflammatory activity has been previously reported. Therefore, the aim of this study was to investigate the hepatoprotective effect of five different extracts of black garlic against carbon tetrachloride (CCl4)-induced acute hepatic injury (AHI). In this study, mice in the control, CCl4, silymarin, and black garlic groups were orally administered distilled water, silymarin, and different fraction extracts of black ga

APA, Harvard, Vancouver, ISO, and other styles

29

Das, Rajat Kumar, Sk Ugir Hossain, and Sudin Bhattacharya. "Protective effect of diphenylmethyl selenocyanate against CCl4-induced hepatic injury." Journal of Applied Toxicology 27, no. 6 (2007): 527–37. http://dx.doi.org/10.1002/jat.1230.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Lin, Jung-Chun, Yi-Jen Peng, Shih-Yu Wang та ін. "Sympathetic Nervous System Control of Carbon Tetrachloride-Induced Oxidative Stress in Liver throughα-Adrenergic Signaling". Oxidative Medicine and Cellular Longevity 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/3190617.

Full text

Abstract:

In addition to being the primary organ involved in redox cycling, the liver is one of the most highly innervated tissues in mammals. The interaction between hepatocytes and sympathetic, parasympathetic, and peptidergic nerve fibers through a variety of neurotransmitters and signaling pathways is recognized as being important in the regulation of hepatocyte function, liver regeneration, and hepatic fibrosis. However, less is known regarding the role of the sympathetic nervous system (SNS) in modulating the hepatic response to oxidative stress. Our aim was to investigate the role of the SNS in h

APA, Harvard, Vancouver, ISO, and other styles

31

Wong, Leo Lap Yan, Sheung Tat Fan, Kwan Man, et al. "Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity." Human & Experimental Toxicology 30, no. 9 (2010): 1369–81. http://dx.doi.org/10.1177/0960327110391388.

Full text

Abstract:

Carbon tetrachloride (CCl4) is a common hepatotoxin used in experimental models to elicit liver injury. To identify the proteins involved in CCl4-induced hepatotoxicity, two-dimensional gel electrophoresis was employed followed by mass spectrometry - mass spectrometry (MS/MS) to study the differentially expressed proteins during CCl4 exposure in the Fischer 344 rat liver proteome for 5 weeks. Ten spots with notable changes between the Control and CCl4 groups were successfully identified. Among them, four proteins with significant up-regulation, namely calcium-binding protein 1, protein disulfi

APA, Harvard, Vancouver, ISO, and other styles

32

Choi, Beom-Rak, Il-Je Cho, Su-Jin Jung, et al. "Lemon Balm and Dandelion Leaf Extracts Synergistically Protect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice." Applied Sciences 11, no. 1 (2021): 390. http://dx.doi.org/10.3390/app11010390.

Full text

Abstract:

Lemon balm and dandelion are commonly used medicinal herbs exhibiting numerous pharmacological activities that are beneficial for human health. In this study, we explored the protective effects of a 2:1 (w/w) mixture of lemon balm and dandelion extracts (MLD) on carbon tetrachloride (CCl4)-induced acute liver injury in mice. CCl4 (0.5 mL/kg; i.p.) injection inhibited body weight gain and increased relative liver weight. Pre-administration of MLD (50–200 mg/kg) for 7 days prevented these CCl4-mediated changes. In addition, histopathological analysis revealed that MLD synergistically alleviated

APA, Harvard, Vancouver, ISO, and other styles

33

Miao, Hui, Yi Zhang, Zhenlin Huang, Bin Lu, and Lili Ji. "Lonicera japonica Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice: Molecular Mechanisms of Action." American Journal of Chinese Medicine 47, no. 02 (2019): 351–67. http://dx.doi.org/10.1142/s0192415x19500174.

Full text

Abstract:

Liver fibrosis is a worldwide clinical issue that generally causes hepatic cirrhosis. Lonicerae Japonicae Flos (dried flower buds of Lonicera japonica Thunb) is a traditional heat-clearing and detoxifying herbal medicine in China. This study aims to observe the protection of the water extract of Lonicerae Japonicae Flos (FL) from carbon tetrachloride (CCl4)-induced liver fibrosis in mice. Liver fibrosis was induced in mice by intraperitoneal injection of 2[Formula: see text]ml/kg CCl4 twice a week for 4 weeks. FL’s attenuation of CCl4-induced liver fibrosis in mice was evidenced by the results

APA, Harvard, Vancouver, ISO, and other styles

34

Huang, Wen-Ge, Jun Wang, Yu-Juan Liu, et al. "Endoplasmic Reticulum Stress Increases Multidrug-resistance Protein 2 Expression and Mitigates Acute Liver Injury." Current Molecular Medicine 20, no. 7 (2020): 548–57. http://dx.doi.org/10.2174/1566524020666200124102411.

Full text

Abstract:

Background: Multidrug-resistance protein (MRP) 2 is a key membrane transporter that is expressed on hepatocytes and regulated by nuclear factor kappa B (NF-κB). Interestingly, endoplasmic reticulum (ER) stress is closely associated with liver injury and the activation of NF-κB signaling. Objective: Here, we investigated the impact of ER stress on MRP2 expression and the functional involvement of MRP2 in acute liver injury. Methods: ER stress, MRP2 expression, and hepatocyte injury were analyzed in a carbon tetrachloride (CCl4)-induced mouse model of acute liver injury and in a thapsigargin (TG

APA, Harvard, Vancouver, ISO, and other styles

35

Zhang, Yiping, Yuanqiao He, Hongbo Yu, Fuying Ma, Jianguo Wu та Xiaoyu Zhang. "Liquiritigenin Protects Rats from Carbon Tetrachloride Induced Hepatic Injury through PGC-1αPathway". Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/649568.

Full text

Abstract:

The lack of effective treatment for liver cirrhosis and hepatocellular carcinomas imposes serious challenges to the healthcare system. Here, we investigated the efficacy and mechanism of liquiritigenin involved in preventing or retarding the progression of liver diseases in a rat model with chronic carbon tetrachloride (CCl4) exposure. Sprague Dawley rats were given CCl4 and lliquiritigenin alone or simultaneously for 8 weeks before liver was harvested to check histological changes by Hematoxylin and Eosin (H&E) staining, apoptosis by TUNEL assay, ROS by dihydroethidium staining, antioxida

APA, Harvard, Vancouver, ISO, and other styles

36

Tsai, Meng-Tsz, Ching-Yi Chen, Yu-Hui Pan, Siou-Huei Wang, Harry J. Mersmann, and Shih-Torng Ding. "Alleviation of Carbon-Tetrachloride-Induced Liver Injury and Fibrosis by Betaine Supplementation in Chickens." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/725379.

Full text

Abstract:

Betaine is a food component with well-reported hepatoprotection effects. However, the effects and mechanisms of betaine on liver fibrosis development are still insufficient. Because metabolic functions of chicken and human liver is similar, we established a chicken model with carbon Tetrachloride- (CCl4-) induced fibrosis for studying antifibrotic effect of betainein vivoandin vitro. Two-week-old male chicks were supplemented with betaine (1%, w/v) in drinking water for 2 weeks prior to the initiation of CCl4treatment (i.p.) until sacrifice. Primary chicken hepatocytes were treated with CCl4an

APA, Harvard, Vancouver, ISO, and other styles

37

Chen, Rui-rong, Juan Liu, Zhe Chen, Wen-jun Cai, Xiu-fen Li, and Chuan-li Lu. "Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress." Evidence-Based Complementary and Alternative Medicine 2020 (March 30, 2020): 1–9. http://dx.doi.org/10.1155/2020/9861571.

Full text

Abstract:

In Southwestern China, the root of Morinda angustifolia Roxb. has been employed as a folk medicine for treating various types of hepatitis and jaundice. The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from M. angustifolia root (AEMA) in carbon tetrachloride- (CCl4-) induced liver injury in mice and identify the main bioactive components. Results indicated that AEMA pretreatment could significantly, in a dose-dependent manner, attenuate the increased levels of ALT and AST in mice serum induced by CCl4. At doses of 100 and 200 mg/kg, AEMA exhibite

APA, Harvard, Vancouver, ISO, and other styles

38

Sharma, Shweta, and Mehta Bk. "COMPARATIVE STUDY OF ALCOHOLIC AND AQUEOUS EXTRACTS OF SYZYGIUM CUMINI ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN WISTAR RATS." Asian Journal of Pharmaceutical and Clinical Research 9, no. 9 (2016): 182. http://dx.doi.org/10.22159/ajpcr.2016.v9s3.14675.

Full text

Abstract:

ABSTRACTObjective: In this investigation, the comparative hepatoprotective effect of aqueous and ethanolic extracts of Syzygium cumini (AESC and EESC,respectively) was studied on carbon tetrachloride (CCl4)-induced hepatic injury in rats. These findings were also compared with the standardhepatoprotective drug silymarin.Methods: Hepatotoxicity was induced by a single dose of CCl4 to healthy Wistar rats. Standard drug (100 mg/kg) and test extracts (500 mg/kg forboth) were given orally for 10 days; the effects were observed using different biochemical and histological methods.Results: In most of

APA, Harvard, Vancouver, ISO, and other styles

39

Awan, Sana Javaid, Maria Tayyab Baig, Faiza Yaqub, Asima Tayyeb, and Gibran Ali. "In vitro differentiated hepatic oval-like cells enhance hepatic regeneration in CCl4-induced hepatic injury." Cell Biology International 41, no. 1 (2016): 51–61. http://dx.doi.org/10.1002/cbin.10699.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Qu, Liping, Hailiang Xin, Guoyin Zheng, Yonghua Su, and Changquan Ling. "Hepatoprotective Activity of the Total Saponins fromActinidia valvataDunn Root against Carbon Tetrachloride-Induced Liver Damage in Mice." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/216061.

Full text

Abstract:

The protective activity of the total saponins fromActinidia valvataDunn root (TSAV) was studied against carbon-tetrachloride- (CCl4-) induced acute liver injury in mice. Mice were orally administered TSAV (50, 100, and 200 mg/kg) for five days and then given CCl4. TSAV pretreatment significantly prevented the CCl4-induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and ALP). Parallel to these changes, TSAV also prevented CCl4-induced oxidative stress by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, GR, and GPX), GSH and GS

APA, Harvard, Vancouver, ISO, and other styles

41

Liu, Wei, Zi Wang, Jin-gang Hou, et al. "The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response." Molecules 23, no. 9 (2018): 2120. http://dx.doi.org/10.3390/molecules23092120.

Full text

Abstract:

The purpose of this research was to evaluate whether maltol could protect from hepatic injury induced by carbon tetrachloride (CCl4) in vivo by inhibition of apoptosis and inflammatory responses. In this work, maltol was administered at a level of 100 mg/kg for 15 days prior to exposure to a single injection of CCl4 (0.25%, i.p.). The results clearly indicated that the intrapulmonary injection of CCl4 resulted in a sharp increase in serum aspartate transaminase (AST) and alanine transaminase (ALT) activities, tumor necrosis factor-α (TNF-α), irreducible nitric oxide synthase (iNOS), nuclear fa

APA, Harvard, Vancouver, ISO, and other styles

42

Zahedi, Kamyar, Sharon L. Barone, Jie Xu, et al. "Hepatocyte-specific ablation of spermine/spermidine-N1-acetyltransferase gene reduces the severity of CCl4-induced acute liver injury." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 5 (2012): G546—G560. http://dx.doi.org/10.1152/ajpgi.00431.2011.

Full text

Abstract:

Activation of spermine/spermidine- N1-acetyltransferase (SSAT) leads to DNA damage and growth arrest in mammalian cells, and its ablation reduces the severity of ischemic and endotoxic injuries. Here we have examined the role of SSAT in the pathogenesis of toxic liver injury caused by carbon tetrachloride (CCl4). The expression and activity of SSAT increase in the liver subsequent to CCl4 administration. Furthermore, the early liver injury after CCl4 treatment was significantly attenuated in hepatocyte-specific SSAT knockout mice (Hep-SSAT-Cko) compared with wild-type (WT) mice as determined b

APA, Harvard, Vancouver, ISO, and other styles

43

Jiang, Wenqian, Youwen Tan, Mengjie Cai, et al. "Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect." Stem Cells International 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/6079642.

Full text

Abstract:

Mesenchymal stem cells (MSCs) have been increasingly applied into clinical therapy. Exosomes are small (30–100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells. Human umbilical cord MSC-derived exosomes (hucMSC-Ex) play important roles in liver repair. However, the effects and mechanisms of hucMSC-Ex on liver injury development remain elusive. Mouse models of acute and chronic liver injury and liver tumor were induced by carbon tetrachloride (CCl4) injection, followed by administration of hucMSC-Ex via the tail vein.

APA, Harvard, Vancouver, ISO, and other styles

44

Chiu, Chun-Ching, Chih-Yang Huang, Tzy-Yen Chen, et al. "Beneficial Effects ofOcimum gratissimumAqueous Extract on Rats with CCl4-Induced Acute Liver Injury." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/736752.

Full text

Abstract:

Ocimum gratissimum(OG) is known as a food spice and traditional herb, which has been recommended for the treatment of various diseases. To investigate the hepatoprotective effect of OG aqueous extract (OGAE), male Wistar rats challenged by carbon tetrachloride (CCl4) were used as the animal model of chronic hepatic injury. Significantly increased serum catalase and DPPH levels were detected in CCl4-administrated rats that were treated with OGAE or silymarin as compared to those rats that were treated with saline or CCl4. In contrast, significantly decreased stress proteins including HSP70 and

APA, Harvard, Vancouver, ISO, and other styles

45

Wu, Yueh-Wern, Kuan-Dee Chen, and Wen-Chuan Lin. "Effect ofGanoderma tsugaeon Chronically Carbon Tetrachloride-Intoxicated Rats." American Journal of Chinese Medicine 32, no. 06 (2004): 841–50. http://dx.doi.org/10.1142/s0192415x04002454.

Full text

Abstract:

The purpose of this study was to evaluate the hepatoprotective and anti-fibrotic actions of crude extracts of Ganoderma tsugae (GTE) on chronic liver injury induced by carbon tetrachloride ( CCl4) in rats. CCl4(20%, 0.5 ml/rat) was given twice a week for 8 weeks, and animals received GTE through the whole experimental period. GTE showed obvious reducing actions on the elevated levels of glutamate-oxalate-transaminase (GOT) and glutamate-pyruvate-transaminase (GPT) caused by CCl4at weeks 3, 6 and 8. Liver fibrosis in rats induced by CCl4led to the drop of serum albumin and hepatic protein conce

APA, Harvard, Vancouver, ISO, and other styles

46

Pan, Yanni, Xingyao Long, Ruokun Yi, and Xin Zhao. "Polyphenols in Liubao Tea Can Prevent CCl4-Induced Hepatic Damage in Mice through Its Antioxidant Capacities." Nutrients 10, no. 9 (2018): 1280. http://dx.doi.org/10.3390/nu10091280.

Full text

Abstract:

The present study investigated the preventive effect of polyphenols in Liubao tea (PLT) on carbon tetrachloride (CCl4)-induced liver injury in mice. The mice were initially treated with PLT, followed by induction of liver injury using 10 mL/kg CCl4. Then liver and serum indices, as well as the expression levels of related messenger RNAs (mRNAs) and proteins in liver tissues were measured. The results showed that PLT reduces the liver quality and indices of mice with liver injury. PLT also downregulates aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglycerides (TGs), and m

APA, Harvard, Vancouver, ISO, and other styles

47

Hsu, Chin-Lin, Chien-Chen Hsu, and Gow-Chin Yen. "Hepatoprotection by Freshwater Clam Extract Against CCl4-Induced Hepatic Damage in Rats." American Journal of Chinese Medicine 38, no. 05 (2010): 881–94. http://dx.doi.org/10.1142/s0192415x10008329.

Full text

Abstract:

Freshwater clam is traditionally used as a food and has been mentioned in ancient books to have a hepatoprotective effect. The hepatoprotective effect of freshwater clam extract was evaluated in the model of chronic hepatic fibrosis induced by carbon tetrachloride ( CCl4 ). Male Sprague-Dawley rats were orally treated with freshwater clam extract (0.3, 0.6 and 1.5 g/kg of bw) or silymarin (0.2 g/kg of bw) along with the administration of CCl4 (0.5 ml/rat, 20% CCl4 in olive oil) for eight consecutive weeks. Blood samples were collected for assaying serum biochemical parameters. The livers were

APA, Harvard, Vancouver, ISO, and other styles

48

Zhang, Feng, Jin Ma, Yin Lu, et al. "Acupuncture Combined with Curcumin Attenuates Carbon Tetrachloride-Induced Hepatic Fibrosis in Rats." Acupuncture in Medicine 30, no. 2 (2012): 132–38. http://dx.doi.org/10.1136/acupmed-2011-010116.

Full text

Abstract:

Background Increasingly, studies demonstrate the effectiveness of acupuncture therapy against liver fibrosis. Curcumin is a natural product with antifibrotic effects, but has poor pharmacokinetic profiles. This study aimed to evaluate whether acupuncture combined with curcumin could more potently attenuate liver fibrosis in chemical intoxicated rats. Methods 60 Sprague–Dawley male rats were randomly divided into control, model, sham, acupuncture, curcumin and combination therapy groups. During the establishment of fibrosis using carbon tetrachloride (CCl4), acupuncture at LR3, LR14, BL18 and S

APA, Harvard, Vancouver, ISO, and other styles

49

Zhang, Feng, Suying Dang, Runzhe Shu, et al. "Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice." International Journal of Toxicology 34, no. 2 (2015): 204–10. http://dx.doi.org/10.1177/1091581814566472.

Full text

Abstract:

Bood POZ containing gene type 2 (BPOZ2), a Broad-Complex, Tramtrack, and Bric a brac domain containing protein, is an adaptor protein for the E3 ubiquitin ligase scaffold protein CUL3. It plays an important role in acute carbon tetrachloride (CCl4)-induced liver injury and regeneration in mice. In this study, we investigated the role of BPOZ2 in the process of liver fibrosis induced by chronic CCl4 treatment. The results indicate that BPOZ2 deficiency decreases sustained activation of hepatic stellate cells, attenuates collagen αI(I) and tissue inhibitor of matrix metalloprotease 1 expression,

APA, Harvard, Vancouver, ISO, and other styles

50

Munakarmi, Suvesh, Lokendra Chand, Hyun Beak Shin, Kyu Yun Jang, and Yeon Jun Jeong. "Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress." International Journal of Molecular Sciences 21, no. 6 (2020): 2048. http://dx.doi.org/10.3390/ijms21062048.

Full text

Abstract:

3,3′-Diindolylmethane (DIM), a metabolic product of indole-3-carbinol extracted from cruciferous vegetables exhibits anti-inflammatory and anti-cancer properties. Earlier, the product has been demonstrated to possess anti-fibrotic properties; however, its protective effects on liver injury have not been clearly elucidated. In this study, we postulated the effects and molecular mechanisms of action of DIM on carbon tetrachloride (CCl4)-induced liver injury in mice. Acute liver injury was induced by a single intraperitoneal administration of CCl4 (1 ml/kg) into mice. DIM was injected via subcuta

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!