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Journal articles on the topic 'CCNE2'

Author: Grafiati

Published: 1 April 2023

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1

Kondo, Yukio, Eric Wieder, Sijie Lu, and Jeffrey Molldrem. "High Avidity Cyclin E1-Derived Peptide-Specific CTL Kill Lymphoid Leukemia Cells and Cross-Recognize a Homologous Cyclin E2-Derived Peptide." Blood 104, no. 11 (2004): 4498. http://dx.doi.org/10.1182/blood.v104.11.4498.4498.

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Abstract Using a similar strategy that successfully identified PR1 as a leukemia-associated antigen (LAA), we identified two homologous HLA-A2-restricted peptides from cyclin E1 (CCNE1) and cyclin E2 (CCNE2) that could be used to elicit peptide-specific CTL from healthy donors in vitro. Two homologous nonameric peptides from CCNE1 (CCNE1144–152) and CCNE2 (CCNE2144–152), which differ by a single amino acid at position 7, have equal binding affinity for HLA-A2 and each elicited peptide-specific CTL with equal efficiency, as measured by specific lysis of T2 cells pulsed with either peptide (CCNE

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2

Sonntag, Roland, Nives Giebeler, Yulia A. Nevzorova, et al. "Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma." Proceedings of the National Academy of Sciences 115, no. 37 (2018): 9282–87. http://dx.doi.org/10.1073/pnas.1807155115.

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E-type cyclins E1 (CcnE1) and E2 (CcnE2) are regulatory subunits of cyclin-dependent kinase 2 (Cdk2) and thought to control the transition of quiescent cells into the cell cycle. Initial findings indicated that CcnE1 and CcnE2 have largely overlapping functions for cancer development in several tumor entities including hepatocellular carcinoma (HCC). In the present study, we dissected the differential contributions of CcnE1, CcnE2, and Cdk2 for initiation and progression of HCC in mice and patients. To this end, we tested the HCC susceptibility in mice with constitutive deficiency for CcnE1 or

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Ishiyama, Ken, Yukio Kondo, Eric Wieder, Sijie Lu, and Jeffrey Molldrem. "High Avidity Cyclin E-Derived Peptide-Specific CTL Contribute to Induction of Remission after Stem Cell Transplantation without Associated Graft-Versus-Host Disease." Blood 106, no. 11 (2005): 1424. http://dx.doi.org/10.1182/blood.v106.11.1424.1424.

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Abstract Cyclin E1 (CCNE1) and cyclin E2 (CCNE2) are cell cycle genes that are overexpressed in AML, ALL, and CML, and in solid tumors such as breast cancer, lung cancer, and gastric cancer. We reported that two homologous nonameric peptides from CCNE1 (CCNE1144-152, ILLDWLMEV) and CCNE2 (CCNE2144-152, ILLDWLLEV), which differ by a single amino acid at position 7, have equal binding affinity for HLA-A2 and that CCNE1- and CCNE2- specific CTL elicited from healthy donors kill ALL and CML cells that overexpress CCNE1 and CCNE2. Interestingly, CCNE1/A2 and CCNE2/A2 tetramers bind to both T-cell r

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He, Hong, Ken Ishiyama, Gheath Alatrash, Yukio Kondo, Sijie Lu, and Jeffrey J. Molldrem. "T-Cell Immunity to Two HLA-A2-Restricted Self-Determinants of Cyclin E May Contribute to Remission After Stem Cell Transplantation." Blood 114, no. 22 (2009): 686. http://dx.doi.org/10.1182/blood.v114.22.686.686.

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Abstract Abstract 686 Cyclin E1 (CCNE1) and cyclin E2 (CCNE2) are tightly regulated cell cycle genes in normal cells but are over-expressed and constitutively active in breast cancer and in the majority of hematological malignances. To validate CCNE as a potential target antigen for T-cells in leukemia, we first confirmed aberrant CCNE1 and CCNE2 protein in PBMC from 26 (93%) of 28 patients (CML = 16; AML = 7; ALL =2; NHL = 3) by Western Blot compared to 4 (33%) of 12 healthy controls (p < 0.0005). Next, we screened the sequences of CCNE1 and CCNE2 for HLA-A*0201 binding motifs and identifi

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Martín-Garcia, David, Alba Navarro, Rafael Valdés-Mas, et al. "CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1− mantle cell lymphoma." Blood 133, no. 9 (2019): 940–51. http://dx.doi.org/10.1182/blood-2018-07-862151.

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Abstract Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in overexpression of cyclin D1. However, a small subset of cyclin D1− MCL has been recognized, and approximately one-half of them harbor CCND2 translocations while the primary event in cyclin D1−/D2− MCL remains elusive. To identify other potential mechanisms driving MCL pathogenesis, we investigated 56 cyclin D1−/SOX11+ MCL by fluorescence in situ hybridization (FISH), whole-genome/exome sequencing, and gene-expression and copy-number arrays. FISH with break-apart probes identified CCND2 rear

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Wu, Lizheng, Kuan Yang, Yajie Gui, and Xiaojing Wang. "Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells." Biochemistry and Cell Biology 98, no. 3 (2020): 354–61. http://dx.doi.org/10.1139/bcb-2019-0156.

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The consumption of nicotine via smoking tobacco has been reported to stimulate the occurrence and progression of periodontitis. Many studies have demonstrated that nicotine prevents the regeneration of periodontal tissues primarily by inhibiting the proliferation of human periodontal ligament (PDL) cells. However, the mechanisms underlying this process are still unclear. Therefore, we investigated whether nicotine-upregulated miR-30a inhibited the proliferation of human PDL cells by downregulating cyclin E2 (CCNE2), in vitro. Quantitative real-time PCR analysis revealed that nicotine upregulat

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Tao, Kaiyi, JinShi Liu, JinXiao Liang, XiaoFang Xu, LiWei Xu, and WeiMin Mao. "Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2." Carcinogenesis 42, no. 8 (2021): 1056–67. http://dx.doi.org/10.1093/carcin/bgab051.

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Abstract This study tried to explore the molecular mechanism underlying progression of lung adenocarcinoma (LUAD) and discuss the extracellular communication between cancer cells and vascular endothelial cells. Roughly, differential analysis was carried out to note that miR-30a-5p was lowly expressed in LUAD, whereas CCNE2 was highly expressed. Cell functional experiments demonstrated that overexpressed miR-30a-5p led to suppressed cell abilities in proliferation, migration and invasion. Dual-luciferase reporter gene assay and RNA immunoprecipitation verified the binding of miR-30a-5p and CCNE

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8

Diab, Sami, Matei P. Socoteanu, Carlos A. Encarnacion, et al. "High-risk breast cancer genes at 8q22-24 and their role in over 5,000 patients evaluated with the 70-gene risk of recurrence assay." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3569. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3569.

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3569 Background: Previous studies have shown that CCNE2 expression is higher in patients’ cancers resistant to CDK4/6 inhibitors. Increased expression of CCNE2, MTDH, or TSPYL5, genes contained within the 70-gene risk of distant recurrence signature (70GS), has also been implicated in breast oncogenesis, poor prognosis, and chemoresistance. These genes are located on chromosome region 8q22.1, one of the most recurrently amplified regions out of all 70GS genes in breast tumors (Fatima et al. 2017). MYC, located on 8q24, is overexpressed in 40% of all breast cancers (BC). Here we examined the ex

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9

Lee, Christine, Kristine J. Fernandez, Sarah Alexandrou, et al. "Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer." Cancers 12, no. 8 (2020): 2268. http://dx.doi.org/10.3390/cancers12082268.

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Genome doubling is an underlying cause of cancer cell aneuploidy and genomic instability, but few drivers have been identified for this process. Due to their physiological roles in the genome reduplication of normal cells, we hypothesised that the oncogenes cyclins E1 and E2 may be drivers of genome doubling in cancer. We show that both cyclin E1 (CCNE1) and cyclin E2 (CCNE2) mRNA are significantly associated with high genome ploidy in breast cancers. By live cell imaging and flow cytometry, we show that cyclin E2 overexpression promotes aberrant mitosis without causing mitotic slippage, and i

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Kikuchi, Kei, and Daisuke Kaida. "CCNE1 and E2F1 Partially Suppress G1 Phase Arrest Caused by Spliceostatin A Treatment." International Journal of Molecular Sciences 22, no. 21 (2021): 11623. http://dx.doi.org/10.3390/ijms222111623.

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The potent splicing inhibitor spliceostatin A (SSA) inhibits cell cycle progression at the G1 and G2/M phases. We previously reported that upregulation of the p27 cyclin-dependent kinase inhibitor encoded by CDKN1B and its C-terminal truncated form, namely p27*, which is translated from CDKN1B pre-mRNA, is one of the causes of G1 phase arrest caused by SSA treatment. However, the detailed molecular mechanism underlying G1 phase arrest caused by SSA treatment remains to be elucidated. In this study, we found that SSA treatment caused the downregulation of cell cycle regulators, including CCNE1,

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Irving-Rodgers, H. F., S. T. Lee, N. Hatzirodos, K. Hummitzsch, T. R. Sullivan, and R. J. Rodgers. "143. DIFFERENCES IN GENE EXPRESSION BETWEEN APICAL AND BASAL CELLS OF THE MEMBRANA GRANULOSA." Reproduction, Fertility and Development 22, no. 9 (2010): 61. http://dx.doi.org/10.1071/srb10abs143.

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Granulosa cells constitute the ovarian follicular epithelium which at the beginning of folliculogenesis forms a single layer of flattened cells. As the follicle matures the cells acquire a cuboidal morphology, proliferate and differentiate into the cumulus cells surrounding the oocyte, and the mural granulosa cells forming the inner layer of the follicle (the membrana granulosa). Mural granulosa cells may further differ in their functionality depending on whether they are situated apically or basally within the stratified membrana granulosa. Late in folliculogenesis granulosa cells develop the

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12

Deng, Yu, He Huang, Jiangcheng Shi, and Hongyan Jin. "Identification of Candidate Genes in Breast Cancer Induced by Estrogen Plus Progestogens Using Bioinformatic Analysis." International Journal of Molecular Sciences 23, no. 19 (2022): 11892. http://dx.doi.org/10.3390/ijms231911892.

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Menopausal hormone therapy (MHT) was widely used to treat menopause-related symptoms in menopausal women. However, MHT therapies were controversial with the increased risk of breast cancer because of different estrogen and progestogen combinations, and the molecular basis behind this phenomenon is currently not understood. To address this issue, we identified differentially expressed genes (DEGs) between the estrogen plus progestogens treatment (EPT) and estrogen treatment (ET) using the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) data. As a result, a total of 96 upregulat

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Xu, Xuting, Limin Xu, Huilian Huang, et al. "Identification of Hub Genes as Biomarkers Correlated with the Proliferation and Prognosis in Lung Cancer: A Weighted Gene Co-Expression Network Analysis." BioMed Research International 2020 (June 11, 2020): 1–11. http://dx.doi.org/10.1155/2020/3416807.

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Lung cancer is one of the most malignant tumors in the world. Early diagnosis and treatment of lung cancer are vitally important to reduce the mortality of lung cancer patients. In the present study, we attempt to identify the candidate biomarkers for lung cancer by weighted gene co-expression network analysis (WGCNA). Gene expression profile of GSE30219 was downloaded from the gene expression omnibus (GEO) database. The differentially expressed genes (DEGs) were analyzed by the limma package, and the co-expression modules of genes were built by WGCNA. UALCAN was used to analyze the relative e

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Feng, Weiliang, Chen Wang, Chenlu Liang, et al. "The Dysregulated Expression of KCNQ1OT1 and Its Interaction with Downstream Factors miR-145/CCNE2 in Breast Cancer Cells." Cellular Physiology and Biochemistry 49, no. 2 (2018): 432–46. http://dx.doi.org/10.1159/000492978.

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Background/Aims: Next-generation sequencing (NGS) has revealed abundant long noncoding RNAs (lncRNAs) that have been characterized as critical components of cancer biology in humans. The present study aims to investigate the role of the lncRNA KCNQ1OT1 in breast cancer (BRCA) as well as the underlying molecular mechanisms and functions of KCNQ1OT1 involved in the progression of BRCA. Methods: The Cancer Genome Atlas (TCGA) and StarBase v2.0 were used to obtain the required gene data. Dual luciferase reporter gene assays were conducted to verify the relevant intermolecular target relationships.

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Zhou, Jian, Wei-Qiang Ju, Xiao-Peng Yuan, Xiao-Feng Zhu, Dong-Ping Wang, and Xiao-Shun He. "miR-26a regulates mouse hepatocyte proliferation via directly targeting the 3' untranslated region of CCND2 and CCNE2." Hepatobiliary & Pancreatic Diseases International 15, no. 1 (2016): 065–72. http://dx.doi.org/10.1016/s1499-3872(15)60383-6.

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16

Welsch, Eva, Eva Schuster, Michael Krainer, et al. "Comparison of RNA Marker Panels for Circulating Tumor Cells and Evaluation of Their Prognostic Relevance in Breast Cancer." Cancers 15, no. 4 (2023): 1271. http://dx.doi.org/10.3390/cancers15041271.

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Liquid biopsy is a promising tool for therapy monitoring of cancer patients, but a need for further research in this field exists in order to improve sensitivity, specificity, standardization and minimize costs. In our present study, we evaluated two panels of transcripts related with the presence of circulating tumor cells (CTCs) (Panel 1: CK19, EpCAM, SCGB2A2 and Panel 2: EMP2, SLC6A8, HJURP, MAL2, PPIC and CCNE2) in two cohorts of breast cancer patients (metastatic and early). A blood cell fraction possibly containing CTCs was isolated with density gradient centrifugation, followed by RNA i

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17

Sotiriou, C., M. Paesmans, A. Harris, et al. "Cyclin E1 (CCNE1) and E2 (CCNE2) as prognostic and predictive markers for endocrine therapy (ET) in early breast cancer." Journal of Clinical Oncology 22, no. 14_suppl (2004): 9504. http://dx.doi.org/10.1200/jco.2004.22.90140.9504.

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Sotiriou, C., M. Paesmans, A. Harris, et al. "Cyclin E1 (CCNE1) and E2 (CCNE2) as prognostic and predictive markers for endocrine therapy (ET) in early breast cancer." Journal of Clinical Oncology 22, no. 14_suppl (2004): 9504. http://dx.doi.org/10.1200/jco.2004.22.14_suppl.9504.

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Pegoraro, Silvia, Gloria Ros, Yari Ciani, Riccardo Sgarra, Silvano Piazza, and Guidalberto Manfioletti. "A novel HMGA1-CCNE2-YAP axis regulates breast cancer aggressiveness." Oncotarget 6, no. 22 (2015): 19087–101. http://dx.doi.org/10.18632/oncotarget.4236.

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Gao, Li, Rong-quan He, Hua-yu Wu, et al. "Expression Signature and Role of miR-30d-5p in Non-Small Cell Lung Cancer: a Comprehensive Study Based on in Silico Analysis of Public Databases and in Vitro Experiments." Cellular Physiology and Biochemistry 50, no. 5 (2018): 1964–87. http://dx.doi.org/10.1159/000494875.

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Background/Aims: The purpose of this study was to probe the clinico-pathological significance and the underlying mechanism of miR-30d-5p expression in non-small cell lung cancer (NSCLC). Methods: We initially examined the level of miR-30d-5p expression in NSCLC and non-cancer tissues using RT-qPCR. Then, a series of validation analyses including a meta-analysis of data from microarray chips in Gene Expression Omnibus (GEO), data mining of the cancer genome atlas (TCGA) and an integrated meta-analysis incorporating GEO microarray chips, TCGA data, in-house RT-qPCR and literature studies were pe

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Zeillinger, R., E. Obermayr, A. Fink-Retter, et al. "Molecular markers for circulating tumor cells in breast cancer." Journal of Clinical Oncology 29, no. 27_suppl (2011): 223. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.223.

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223 Background: Recently, we identified a six gene panel (CCNE2, DKFZp762E1312, EMP2, MAL2, PPIC, and SLC6A8) for the RT-qPCR based detection of circulating tumor cells (CTC) in breast cancer patients. The aim of the present study was to evaluate the gene panel in further blood samples. Methods: Blood samples were taken from breast cancer patients with metastatic disease (MBC, N=10) or with no evidence of disease (NED, N=30). Putative CTC were enriched by Oncoquick density gradient centrifugation. Total RNA was isolated with RNeasy Micro Kit (QIAgen). Template cDNA was generated with M-MLV Rev

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Shao, Li, Ri-Cheng Chian, Yixin Xu, et al. "Genomic expression profiles in cumulus cells derived from germinal vesicle and MII mouse oocytes." Reproduction, Fertility and Development 28, no. 11 (2016): 1798. http://dx.doi.org/10.1071/rd15077.

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Cumulus cells (CCs) are distinct from other granulosa cells and the mutual communication between CCs and oocytes is essential for the establishment of oocyte competence. In the present study we assessed genomic expression profiles in mouse CCs before and after oocyte maturation in vitro. Microarray analysis revealed significant changes in gene expression in CCs between the germinal vesicle (GV) and metaphase II (MII) stages, with 2615 upregulated and 2808 downregulated genes. Genes related to epidermal growth factor, extracellular matrix (Ptgs2, Ereg, Tnfaip6 and Efemp1), mitochondrial metabol

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Mizuno, Keiko, Kengo Tanigawa, Shunsuke Misono, et al. "Regulation of Oncogenic Targets by Tumor-Suppressive miR-150-3p in Lung Squamous Cell Carcinoma." Biomedicines 9, no. 12 (2021): 1883. http://dx.doi.org/10.3390/biomedicines9121883.

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Several recent studies have shown that both strands of certain miRNAs derived from miRNA duplexes are involved in cancer pathogenesis. Our own recent studies revealed that both strands of the miR-150 duplex act as tumor-suppressive miRNAs in lung adenocarcinoma (LUAD) through the targeting of several oncogenes. The aim of the study here was to further investigate the tumor-suppressive roles of miR-150-3p (the passenger strand) in lung squamous cell carcinoma (LUSQ) and its control of cancer-promoting genes in LUSQ cells. The downregulation of miR-150-3p in LUSQ tissues was confirmed by data in

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Liu, Cui-Zhen, Wan-Ping Guo, Jin-Bo Peng, et al. "Clinical significance of CCNE2 protein and mRNA expression in thyroid cancer tissues." Advances in Medical Sciences 65, no. 2 (2020): 442–56. http://dx.doi.org/10.1016/j.advms.2020.09.001.

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Wu, Deqin, Jing He, Wei Zhang, et al. "CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression." Aging 12, no. 11 (2020): 10578–93. http://dx.doi.org/10.18632/aging.103280.

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26

Kabir, Mohammad Faujul, Johari Mohd Ali, and Onn Haji Hashim. "Microarray gene expression profiling in colorectal (HCT116) and hepatocellular (HepG2) carcinoma cell lines treated withMelicope ptelefolialeaf extract reveals transcriptome profiles exhibiting anticancer activity." PeerJ 6 (July 18, 2018): e5203. http://dx.doi.org/10.7717/peerj.5203.

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BackgroundWe have previously reported anticancer activities ofMelicope ptelefolia(MP) leaf extracts on four different cancer cell lines. However, the underlying mechanisms of actions have yet to be deciphered. In the present study, the anticancer activity of MP hexane extract (MP-HX) on colorectal (HCT116) and hepatocellular carcinoma (HepG2) cell lines was characterized through microarray gene expression profiling.MethodsHCT116 and HepG2 cells were treated with MP-HX for 24 hr. Total RNA was extracted from the cells and used for transcriptome profiling using Applied Biosystem GeneChip™ Human

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Yu, Ai Qing, Zhi Xiao Wang, Wu Wu, Ke Yu Chen, Shi Rong Yan, and Ze Bin Mao. "Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2." Aging 11, no. 22 (2019): 10220–41. http://dx.doi.org/10.18632/aging.102449.

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Minegishi, Naoko, Hideo Harigae, and Masayuki Yamamoto. "Bidirectional Control of Transcription Factor GATA2 and Cyclin/Cdks in Hematopoietic Cells." Blood 112, no. 11 (2008): 1382. http://dx.doi.org/10.1182/blood.v112.11.1382.1382.

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Abstract GATA2 is a transcription factor indispensable for development and maintenance of hematopoietic stem cells. Hematopoietic stem cells in G0 phase express GATA2 (Suzuki N, PNAS 103: 2202 2006), but proliferating hematopoietic progenitor cells, as well as proliferating cells in several other tissues, also express this factor. Gata2 knockout experiments indicate that GATA2 regulates cell proliferation; however, precise mechanisms have not been elucidated. Previously, we found oscillatory expressions of GATA2 during the cell cycle. In G1/S and G2/M phases, Cdk4 and Cdk2, forming complexes w

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Büchel, Janine, Maria Bartosova, Gwendolyn Eich, et al. "Interference of Peritoneal Dialysis Fluids with Cell Cycle Mechanisms." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 35, no. 3 (2015): 259–74. http://dx.doi.org/10.3747/pdi.2013.00010.

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Introduction Peritoneal dialysis fluids (PDF) differ with respect to osmotic and buffer compound, and pH and glucose degradation products (GDP) content. The impact on peritoneal membrane integrity is still insufficiently described. We assessed global genomic effects of PDF in primary human peritoneal mesothelial cells (PMC) by whole genome analyses, quantitative real-time polymerase chain reaction (RT-PCR) and functional measurements. Methods PMC isolated from omentum of non-uremic patients were incubated with conventional single chamber PDF (CPDF), lactate- (LPDF), bicarbonate- (BPDF) and bic

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Gorjala, P., J. G. Cairncross, and R. K. Gary. "p53-dependent up-regulation of CDKN1A and down-regulation of CCNE2 in response to beryllium." Cell Proliferation 49, no. 6 (2016): 698–709. http://dx.doi.org/10.1111/cpr.12291.

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Gao, Peng, Huan Wang, Jiarui Yu, et al. "miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2." PLOS Genetics 14, no. 12 (2018): e1007790. http://dx.doi.org/10.1371/journal.pgen.1007790.

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Li, Chuan, Zhi Peng, You Zhou, et al. "Comprehensive analysis of pathological changes in hip joint capsule of patients with developmental dysplasia of the hip." Bone & Joint Research 10, no. 9 (2021): 558–70. http://dx.doi.org/10.1302/2046-3758.109.bjr-2020-0421.r2.

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Aims Developmental dysplasia of the hip (DDH) is a complex musculoskeletal disease that occurs mostly in children. This study aimed to investigate the molecular changes in the hip joint capsule of patients with DDH. Methods High-throughput sequencing was used to identify genes that were differentially expressed in hip joint capsules between healthy controls and DDH patients. Biological assays including cell cycle, viability, apoptosis, immunofluorescence, reverse transcription polymerase chain reaction (RT-PCR), and western blotting were performed to determine the roles of the differentially e

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Zhuang, Liping, Zongguo Yang, and Zhiqiang Meng. "Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in Tumor Tissues Predicted Worse Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma Patients." BioMed Research International 2018 (September 30, 2018): 1–8. http://dx.doi.org/10.1155/2018/7897346.

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Objective. To evaluate the association between upregulated differentially expressed genes (DEGs) and the outcomes of patients with hepatocellular carcinoma (HCC). Methods. Using Gene Expression Omnibus (GEO) datasets including GSE45436, GSE55092, GSE60502, GSE84402, and GSE17548, we detected upregulated DEGs in tumors. KEGG, GO, and Reactome enrichment analysis of the DEGs was conducted to clarify their function. The impact of the upregulated DEGs on patients’ survival was analyzed based on TCGA profile. Results. 161 shared upregulated DEGs were identified among GSE45436, GSE55092, GSE60502, a

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Lei, Brian, and Anjana Saxena. "Abstract C049: Investigating cancer racial disparities through TCGA transcriptomic and proteomic database." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): C049. http://dx.doi.org/10.1158/1538-7755.disp22-c049.

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Abstract In the United States, epidemiological studies have highlighted a disparity in cancer incidence and outcome rates between racial groups. This disparity is attributed to numerous factors, including gene polymorphisms, differences in lifestyle and environmental exposures, and socioeconomic factors. Although an abundance of tumor molecular data exists, the effect of race on gene expression signatures often remains unexplored. In this project, we investigated racial molecular differences in tumors of 10 carcinoma types. We used publicly available data from The Cancer Genome Atlas (TCGA) in

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Entin, Igor, Shmuel Yaccoby, Wen Zhining, John Shaughnessy, Bart Barlogie, and Joshua Epstein. "Myeloma Cell Interaction with Osteoclasts and Mesenchymal Stem Cells Reveals Genes Associated with Post Relapse Survival." Blood 116, no. 21 (2010): 2957. http://dx.doi.org/10.1182/blood.v116.21.2957.2957.

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Abstract Abstract 2957 Myeloma is intimately associated with osteolytic bone disease, resulting from myeloma cells' interactions with osteoclasts and osteoblasts and their progenitors, and is dependent on the changes it induces in bone metabolism for progression. Myeloma cell dependence on the bone marrow microenvironment is also evident experimentally, where interaction of primary myeloma plasma cells (MMPC) with osteoclasts (OC) and with mesenchymal stem cells (MSC) support the survival of primary myeloma cells. To understand the molecular mechanisms associated with the survival of MMPC, we

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Yang, Jie, Zhen Dong, Aishu Ren, et al. "Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down‐regulating CCNE2 in pancreatic ductal adenocarcinoma." Journal of Cellular and Molecular Medicine 24, no. 7 (2020): 4245–60. http://dx.doi.org/10.1111/jcmm.15086.

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Gong, Ke, Huiling Zhou, Haidan Liu, et al. "Identification and Integrate Analysis of Key Biomarkers for Diagnosis and Prognosis of Non-Small Cell Lung Cancer Based on Bioinformatics Analysis." Technology in Cancer Research & Treatment 20 (January 2021): 153303382110602. http://dx.doi.org/10.1177/15330338211060202.

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Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer affecting humans. However, appropriate biomarkers for diagnosis and prognosis have not yet been established. Here, we evaluated the gene expression profiles of patients with NSCLC to identify novel biomarkers. Methods: Three datasets were downloaded from the Gene Expression Omnibus (GEO) database, and differentially expressed genes were analyzed. Venn diagram software was applied to screen differentially expressed genes, and gene ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG)

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Li, Dongfeng, Zaixu Pan, Kun Zhang, et al. "Identification of the Differentially Expressed Genes of Muscle Growth and Intramuscular Fat Metabolism in the Development Stage of Yellow Broilers." Genes 11, no. 3 (2020): 244. http://dx.doi.org/10.3390/genes11030244.

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High-quality chicken meat is an important source of animal protein for humans. Gene expression profiles in breast muscle tissue were determined, aiming to explore the common regulatory genes relevant to muscle and intramuscular fat (IMF) during the developmental stage in chickens. Results show that breast muscle weight (BMW), breast meat percentage (BMP, %), and IMF (%) continuously increased with development. A total of 256 common differentially expressed genes (DEGs) during the developmental stage were screened. Among them, some genes related to muscle fiber hypertrophy were upregulated (e.g

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Ke, Shandong, and Xiaofen Zhou. "LncRNA MVIH knockdown inhibits the malignancy progression through downregulating miR-505 mediated HMGB1 and CCNE2 in acute myeloid leukemia." Translational Cancer Research 8, no. 7 (2019): 2526–34. http://dx.doi.org/10.21037/tcr.2019.10.12.

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Chen, Di, Weijie Guo, Zhaoping Qiu, et al. "MicroRNA-30d-5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non-small cell lung cancer." Cancer Letters 362, no. 2 (2015): 208–17. http://dx.doi.org/10.1016/j.canlet.2015.03.041.

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Ishiyama, Ken, Yukio Kondo, Eric Wieder, Sijie Lu, and Jeffrey Molldrem. "Aberrantly expressed neutrophil elastase (ELA2) in the nucleus and cytoplasm of acute lymphocytic leukemia (ALL) cells cleaves cyclin E (CCNE) into low-molecular-weight forms (LMWFs) yielding novel HLA-A2 restricted determinants (50.28)." Journal of Immunology 178, no. 1_Supplement (2007): S95—S96. http://dx.doi.org/10.4049/jimmunol.178.supp.50.28.

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Abstract We reported that CCNE-specific CTL elicited from healthy donors (HDs) kill ALL and CML cells, which aberrantly express CCNE. Further, 5 LMWFs of CCNE1 are present only in malignant cells and constitutively active to promote cell division. In addition, we showed ELA2-specific CTL also kill AML and CML, and ELA2 is normally expressed only in myeloid cells. To determine whether ELA2 might be aberrantly expressed in ALL and whether ELA2 cleaves CCNE to LMWF’s, we first found CCNE of LMWF to be overexpressed by western blot of cell lysates from ALL, but not from ALL in remission or HD B-ce

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Bae, Jung Yoon, Jun Kanamune, Dong-Wook Han, Kazuaki Matsumura, and Suong-Hyu Hyon. "Reversible Regulation of Cell Cycle-Related Genes by Epigallocatechin Gallate for Hibernation of Neonatal Human Tarsal Fibroblasts." Cell Transplantation 18, no. 4 (2009): 459–69. http://dx.doi.org/10.3727/096368909788809776.

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We investigated the hibernation effect of epigallocatechin-3- O-gallate (EGCG) on neonatal human tarsal fibroblasts (nHTFs) by analyzing the expression of cell cycle-related genes. EGCG application to culture media moderately inhibited the growth of nHTFs, and the removal of EGCG from culture media led to complete recovery of cell growth. EGCG resulted in a slight decrease in the cell population of the S and G2/M phases of cell cycle with concomitant increase in that of the G0/G1 phase, but this cell cycle profile was restored to the initial level after EGCG removal. The expression of cyclin D

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Shi, Hao, Gao-Feng Liang, Yang Li, et al. "Preparation and Evaluation of Upconversion Nanoparticles Based miRNA Delivery Carrier in Colon Cancer Mice Model." Journal of Biomedical Nanotechnology 15, no. 11 (2019): 2240–50. http://dx.doi.org/10.1166/jbn.2019.2840.

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Therapeutic efficacy of solid tumor is often severely hampered by poor penetration of therapeutics into diseased tissues and lack of tumor targeting. In this study, the functionalized upconversion nanoparticles (UCNP)-based delivery vector targeting cancer cells was developed. Firstly, NaYF4:Yb/Tm (UCNP) was prepared with the solvothermal method for the uniform nanoparticle size and brilliant lattice structure. The SiO2 coated UCNP was demonstrated a high upconversion emission and good monodispersity, which was coupled with polyetherimide (PEI) and miR-145 vector. Then, it was further function

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Wang, Ji-fang, Zhuo-na Xi, Hong-jian Su, Zhen Bao, and Ya-hong Qiao. "SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis." Human Cell 34, no. 3 (2021): 952–64. http://dx.doi.org/10.1007/s13577-021-00518-y.

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Lin, Ruoyang, Xianfan Lin, Jinming Wu, Tanzhou Chen, and Zhiming Huang. "Inhibitory Effects of Rabdosia rubescens in Esophageal Squamous Cell Carcinoma: Network Pharmacology and Experimental Validation." Evidence-Based Complementary and Alternative Medicine 2022 (November 10, 2022): 1–16. http://dx.doi.org/10.1155/2022/2696347.

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Esophageal squamous cell carcinoma (ESCC) is one of the most frequently occurring diseases in the world. Rabdosia rubescens (RR) has been demonstrated to be effective against ESCC; however, the mechanism is unknown. The primary gene modules related to the clinical characteristics of ESCC were initially investigated in this research using weighted gene co-expression network analysis (WCGNA) and differential expression gene (DEG) analysis. We employed network pharmacology to study the hub genes linked with RR therapy on ESCC. A molecular docking simulation was achieved to identify the binding ac

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Yang, Bo, Junying Zhang, Yaling Yin, and Yuanyuan Zhang. "Network-Based Inference Framework for Identifying Cancer Genes from Gene Expression Data." BioMed Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/401649.

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Great efforts have been devoted to alleviate uncertainty of detected cancer genes as accurate identification of oncogenes is of tremendous significance and helps unravel the biological behavior of tumors. In this paper, we present a differential network-based framework to detect biologically meaningful cancer-related genes. Firstly, a gene regulatory network construction algorithm is proposed, in which a boosting regression based on likelihood score and informative prior is employed for improving accuracy of identification. Secondly, with the algorithm, two gene regulatory networks are constru

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Borradaile, Nica M., and J. Geoffrey Pickering. "Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase." American Journal of Physiology-Cell Physiology 298, no. 1 (2010): C66—C74. http://dx.doi.org/10.1152/ajpcell.00357.2009.

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Polyploid endothelial cells are found in aged and atherosclerotic arteries. However, whether increased chromosome content has an impact on endothelial cell function is unknown. We show here that human aortic endothelial cells become tetraploid as they approach replicative senescence. Furthermore, accumulation of tetraploid endothelial cells was accelerated during growth in high glucose. Interestingly, induction of polyploidy was completely prevented by modest overexpression of the NAD+ regenerating enzyme, nicotinamide phosphoribosyltransferase (Nampt). To determine the impact of polyploidy on

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Zeng, Lu, Xiude Fan, Xiaoyun Wang, et al. "Bioinformatics Analysis based on Multiple Databases Identifies Hub Genes Associated with Hepatocellular Carcinoma." Current Genomics 20, no. 5 (2019): 349–61. http://dx.doi.org/10.2174/1389202920666191011092410.

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Background: Hepatocellular carcinoma (HCC) is the most common liver cancer and the mechanisms of hepatocarcinogenesis remain elusive. Objective: This study aims to mine hub genes associated with HCC using multiple databases. Methods: Data sets GSE45267, GSE60502, GSE74656 were downloaded from GEO database. Differentially expressed genes (DEGs) between HCC and control in each set were identified by limma software. The GO term and KEGG pathway enrichment of the DEGs aggregated in the datasets (aggregated DEGs) were analyzed using DAVID and KOBAS 3.0 databases. Protein-protein interaction (PPI) n

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Lin, Chiao-Yun, Ren-Chin Wu, Chen-Yang Huang, et al. "A Patient-Derived Xenograft Model of Dedifferentiated Endometrial Carcinoma: A Proof-of-Concept Study for the Identification of New Molecularly Informed Treatment Approaches." Cancers 13, no. 23 (2021): 5962. http://dx.doi.org/10.3390/cancers13235962.

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Conventional treatment of dedifferentiated endometrial carcinoma (DEC)–an uncommon and highly aggressive uterine malignancy–is beset by high failure rates. A line of research that holds promise to overcome these limitations is tailored treatments targeted on specific molecular alterations. However, suitable preclinical platforms to allow a reliable implementation of this approach are still lacking. Here, we developed a patient-derived xenograft (PDX) model for preclinical testing of investigational drugs informed by molecular data. The model–termed PDX-mLung was established in mice implanted w

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Haydé, Vergara-Castañeda, Guevara-González Ramón, Guevara-Olvera Lorenzo, et al. "Non-digestible fraction of beans (Phaseolus vulgarisL.) modulates signalling pathway genes at an early stage of colon cancer in Sprague–Dawley rats." British Journal of Nutrition 108, S1 (2012): S145—S154. http://dx.doi.org/10.1017/s0007114512000785.

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Colorectal cancer is one of the most common causes of morbidity and mortality in Western countries, the second cause of cancer mortality in the USA and a major public health problem in Mexico. A diet rich in legumes is directly related to the prevention of colon cancer, showing an inverse relationship with the development of colorectal adenomas in human subjects. The present study shows the results of molecular changes involved in theTp53pathway at an early stage in the distal colon tissue of azoxymethane (AOM)-induced colon cancer in rats evaluated by PCR array after exposure to diets contain

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