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Lin, Yung-Wei (Dennis). "Contemporary Research on Child-Centered Play Therapy (CCPT) Modalities: A Meta-Analytic Review of Controlled Outcome Studies." Thesis, University of North Texas, 2011. https://digital.library.unt.edu/ark:/67531/metadc68001/.
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The present meta-analytic study estimated the overall effectiveness of child therapy interventions using CCPT methodology and explored the relationships between study characteristics and treatment effects. Fifty-two studies between 1995 and the present were included based on the following criteria: (a) the use of CCPT methodology, (b) the use of control or comparison repeated measure design, (c) the use of standardized psychometric assessment, and (d) clear reports of effect sizes or sufficient information for effect size calculation. Hierarchical linear modeling (HLM) techniques were utilized to estimate the overall effect size for the collected studies and explore relationships between effect sizes and study characteristics. Dependent variable included 239 effect sizes, and independent variables included 22 study characteristics. The mean age of all child participants in the collected studies was 6.7. In 15 studies, the majority of participants were Caucasian. An equal number of studies were made up of non-Caucasian participants, including 3 with majority African American, 4 with majority Hispanic/Latino participants, 5 with majority Asian/Asian American participants, and 3 with other ethnic populations. Study collection included 33 studies with majority of boys and 11 studies with majority of girls. HLM analysis estimated a statistically significant overall effect size of 0.47 for the collected studies (p < 0.001). This result indicated that the overall improvement from pre to post treatment demonstrated by children in experimental groups was approximately 1/2 standard deviation better than by children in control groups. A statistically significant amount (49.2%) of between-study variance was found (p < 0.001), indicating the heterogeneity among the 52 studies Statistically significant relationships were found between effect sizes and study characteristics including child age, child ethnicity, clinical level of referral, treatment integrity, presenting issue, source of data, population, and caregiver involvement. Effect size findings for CCPT and its moderators should be interpreted in light of the specific, and perhaps more rigorous statistical analysis method (HLM) and effect size calculation formula used for the present study, particularly in comparison to previous meta-analytic findings. Overall findings support CCPT's beneficial treatment effect. Specifically, CCPT can be considered a developmentally and culturally responsive effective mental health intervention across presenting issues.
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Rivero, Thiago Strahler [UNIFESP]. "Análise do desempenho dos índices do Conners´ Continuous Performance Test (CCPT) em uma amostra de adolescentes com TDAH." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/8925.
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Previous issue date: 2010-02-24<br>Introdução: O Transtorno do Déficit de Atenção e Hiperatividade (TDAH) é um transtorno neuropsiquiátrico de início precoce que afeta diversos domínios cognitivos, no entanto estudos que investigam na adolescência como o transtorno afeta esses domínios ainda são escassos. Objetivo: O presente estudo investigou o desempenho de uma amostra clínica de adolescentes com TDAH no Conners` Continuous Performance Test (CCPT). Métodos: 28 sujeitos com TDAH (17 masculino) de idade entre 12 e 18 anos participaram do estudo. Análises estatísticas das 15 medidas do CCPT foram realizadas entre o grupo TDAH e controle, além da análise fatorial proposta por Egeland e Kovalick-Gran (2009) entre os subtipos TDAH combinado (n=15) e TDAH desatento (n=13), nas quais as 15 medidas são reduzidas a 5 fatores: atenção focada, hiperatividade/impulsividade, atenção sustentada, vigilância e mudança no controle. Foi realizada ainda uma análise de correlação entre os 5 fatores e medidas cognitivas de memória operacional, função executiva, praxia visuo-construtiva, QI, entre outras. Resultados: O grupo TDAH apresentou déficit em treze das quinze medidas avaliadas pelo CCPT quando comparado ao grupo controle. Na avaliação dos cinco fatores, ambos os subtipos de TDAH apresentaram prejuízos em atenção focada, sustentada e vigilância quando comparados ao grupo controle. Não houve diferenças estatísticas entre os subtipos de TDAH em nenhum dos fatores. Foram encontradas correlações significativas entre medidas cognitivas de memória operacional visuo-espacial, visuo-construção e comportamento aferido pelo professor em todos os cinco fatores. Conclusões: A análise das 15 medidas no grupo TDAH corroborou estudos anteriores. Já a análise dos cinco fatores, proposta recente da literatura, mostrou relevância quanto à diferenciação entre grupo clínico e controle, entretanto sem resultados significativos para dissociação entre subtipos combinado e desatento.<br>TEDE<br>BV UNIFESP: Teses e dissertações
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Barcenas, Jaimez Gustavo. "Child-Centered Play Therapy (CCPT) with Latina/o Children Exhibiting School Behavior Problems: Comparative Effects of Delivery by Spanish-Speaking and English-Speaking Counselors." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1062839/.
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The shortage of bilingual counselors is one barrier to young Latina/o children receiving mental health services. Child-centered play therapy (CCPT) is a developmentally responsive intervention based on the premise that play is children's natural means of communication across cultures. This randomized controlled study examined the effects of CCPT with young Spanish-speaking Latina/o children exhibiting clinical levels of school behavior problems. Participants were 57 pre-K to kindergarten Latina/o children (72% male; mean age = 4.0) randomly assigned to three treatment groups: CCPT with Spanish-speaking, bilingual counselors; CCPT with English-speaking, monolingual counselors; or active control (bilingual mentoring). Monolingual counselors participated in cultural competency training and supervision with bilingual counselors and supervisors. According to independent observers and teachers blinded to children's group assignment, both the bilingual CCPT group and the monolingual CCPT group demonstrated moderate treatment effects over bilingual mentoring, yet between-group differences were not statistically significant. Analysis of within-group change over time indicated that children in both CCPT interventions demonstrated statistically significant improvement, while the mentoring group did not. The percentage of children in each treatment group who improved from clinical to normal behavioral functioning suggests the clinical significance of the findings: 80% bilingual CCPT, 70% monolingual CCPT, 15% bilingual mentoring. Overall, findings indicate that CCPT, whether delivered by bilingual counselors or culturally-competent, monolingual counselors, is a promising intervention for young Latina/o children exhibiting behavior problems.
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Tucker, Sarah K. "The Impact of Child-Centered Play Therapy on Academic Achievement of Children in Poverty." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703300/.
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Childhood poverty is a prevalent concern in the United States and is associated with poor psychological and academic outcomes. Psychosocial stressors associated with life in poverty may interrupt the development of a positive self-concept, ultimately hampering the academic achievement of children in poverty. As the therapeutic objectives of child-centered play therapy (CCPT) support the development of an increasingly positive self-concept, I explored the impact of CCPT on the academic achievement of children in poverty. Participants were composed of 55 students between the ages of 4-7 years old from seven Title 1 elementary schools in the southern United States. Of the 55 study participants, 12 (22%) were female and 43 (78%) were male. Regarding participant ethnicity, 7 (13%) were African American, 1 (2%) was Asian American, 5 (9%) were multi-racial, 35 (64%) were Latino, 6 (11%) were Caucasian, and 1 (2%) did not report ethnicity. Participants were randomly assigned to either a 16 session CCPT treatment group (n = 25) or a waitlist control group (n = 30). A mixed between-within ANOVA was conducted to evaluate improvement in academic achievement scores between treatment and control groups across time. Results indicated a statistically significant interaction effect on the Early Achievement Composite Score of the Young Children's Achievement Test (p = .042). The standardized difference between groups was Cohen's d = .53 indicating a medium effect size. Overall, findings from this study support CCPT as an effective intervention to promote improvements in the academic achievement of children in poverty.
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Turley, Stich Erin. "An Historical Biography of Virginia Axline." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1703343/.
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Virginia Axline developed a new field of child psychotherapy by applying a nondirective approach to the burgeoning experimentation of utilizing play in therapeutic work with children. While much biographical information is available regarding other leaders in the fields of counseling and psychology, historical research into Axline and her development of child-centered play therapy represent a gap in the literature. The purpose of the current study was to: 1) examine the professional contributions of Virginia Axline; 2) gather personal information regarding Axline that contributes to deeper understanding of her theory; and 3) identify life circumstances or events that influenced Axline's professional contributions. Historical methodology was utilized to locate and examine artifacts and materials necessary to create an interpretive biography of Axline's life and work, with a focus on her professional influences, experiences, and contributions. Historical methods utilized include historiography, oral history, and interpretive biography, with an emphasis on established and accepted source criticism and data synthesis processes. The research yielded a number of historically significant and previously unknown documents valuable to the field of CCPT including personal correspondence, academic writings, and interviews, as well as academic and government records. The research also established new information about and understandings of several of Axline's professional relationships. The research also calls into question the original authorship of scholarly contributions in the field of counseling for which Axline may have deserved, but not received credit. Included in the biography is information related to Axline's early life, higher education, career timeline, professional development, mentoring relationships, research interests, student perceptions, collegial relationships, personal hardships, professional interests and advocacy, teaching and learning methods, and her decline in later life.
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Sierpe, Santander Alejandra Valeria. "Parque Inundable : Centro Cultural Parque Inundable : CCPI." Tesis, Universidad de Chile, 2012. http://www.repositorio.uchile.cl/handle/2250/112684.
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Arquitecto<br>El interés y la elección por desarrollar esta investigación, nace a partir dek cuestionamiento del Espacio Público y de cómo generar áreas verdes de calidad y sustentables, en las comunas de la periferia humilde de Santiago.
La ciudad se ha densificado más rápido de lo esperado y el mantenimiento de las áreas verdes y espacios recreativos existente y la creación de nuevos, no ha ido al mismo ritmo, dejando un déficit considerable. Ante lo expuesto es que el tema de los Parques Urbanos, como un tipo de espacio público, cobra especial importancia. Ya que son una oportunidad para dar dinamismo y calidad a nuestras ciudades. Trayendo consigo beneficios sociales y ambientales.
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Paquin, Jean-Nicolas. "Réalisation d'un modèle d'interconnexion CCHT sous EMTP-RV." Mémoire, École de technologie supérieure, 2007. http://espace.etsmtl.ca/597/1/PAQUIN_Jean%2DNicolas.pdf.
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Ce document traite de la réalisation d'une interconnexion CCHT sous EMTP-RV. Les travaux effectués dans ce domaine sont tout d'abord passés en revue. La problématique liée à cette technologie est ensuite présentée. Subséquemment, les divers éléments et les systèmes de commande et de protection développés dans le modèle sont détaillés. Les actions portées par les systèmes de protection lors de divers types de défauts sont ensuite mises en évidence. Une validation complète du modèle est présentée. Tout d'abord, ce dernier est comparé avec celui existant sous SPS, une librairie de Matlab/Simulink. Ensuite, la robustesse des commandes et protections est mise à l'épreuve par la simulation du modèle de référence du CIGRÉ dont les conditions d'opération sont sévères. Finalement, le comportement général du modèle en présence de multiples perturbations est analysé à l'aide de résultats obtenus de la simulation de l'interconnexion en configuration bipolaire.
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Gao, Yu. "Innovative Self-Centering Connection for CCFT Composite Columns." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/78390.
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Concrete filled steel tubes are regarded as ideal frame members in seismic resisting systems, as they combine large axial and flexural capacity with ductility. The combination of the two materials increases the strength of the confined concrete and avoids premature local buckling of the steel tube. These benefits are more prominent for circular than for rectangular concrete filled steel tubes. However, most common connection configurations for circular concrete filled tubes are not economic in the US market due to (a) the desire of designers to use only fully restrained connections and its associated (b) high cost of fabrication and field welding. Research indicates that well designed partially restrained connections can supply equal or even better cyclic behavior. Partially restrained connections also possess potential capability to develop self-centering system, which has many merits in seismic design.
The goal of this research is to develop a new connection configuration between circular concrete filled steel columns and conventional W steel beams. The new connection configuration is intended to provide another option for rapid assembling on site with low erection costs. The proposed connection is based on an extended stiffened end plate that utilizes through rods. The rods are a combination of conventional steel and shape memory alloy that provide both energy dissipation and self-centering capacity. The new connection configuration should be workable for large beam sizes and can be easily expanded to a biaxial bending moment connection.<br>Ph. D.
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Medina, Porcile Catalina. "CCAT-prime telescope holography simulations and surface error analysis." Tesis, Universidad de Chile, 2019. http://repositorio.uchile.cl/handle/2250/170183.
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Tesis para optar al grado de Magíster en Ciencias de la Ingeniería, Mención Eléctrica<br>Memoria para optar al título de Ingeniera Civil Eléctrica<br>El radio-telescopio CCAT-prime (CCAT-p) será construido en el Cerro Chajnantor a 5.600
m.s.n.m en la Región de Antofagasta, Chile. Este telescopio tendrá una configuración CrossedDragone con dos reflectores de 6 m. Esta configuración le otorga un amplio campo de visión
con el que podrá iluminar más de 105 detectores.
El rango de operación del CCAT-p comprende longitudes de onda desde los 350 µm hasta los 3.100 µm, y en las mejores condiciones climáticas podrá llegar hasta la ventana de 200
µm. Para operar a estas longitudes de onda se necesita que la superficie de los reflectores
tenga una alta precisión, por lo que se ha impuesto una meta para el error medio de frente
de ondas entre 7 y 10 µm RMS.
Los reflectores del telescopio serán construidos mediante un set de paneles que en conjunto
conformarán el perfil deseado. Para lograr la precisión requerida, se necesitará implementar
un método de medición de errores en la superficie de los reflectores. Se ha escogido con este
fin la técnica de holografía de ondas milimétricas.
La implementación de técnicas de holografía para el CCAT-p presenta desafíos, debido principalmente a su ubicación, a su configuración óptica y al alto nivel de precisión deseado. Se
utilizará una fuente artificial a 300 m del telescopio, lo cual corresponde a su campo cercano
, por lo que se necesita estudiar el comportamiento del patrón de radiación a esta distancia.
En este trabajo se hacen simulaciones tanto en campo cercano como en campo lejano, bajo distintos escenarios, para así generar datos del comportamiento del telescopio ante estas
circunstancias. Por otro lado, ya que el telescopio consta de dos grandes reflectores, el error
medido por el sistema de holografía corresponderá a las contribuciones de los errores en la
superficie de cada reflector. Para identificar y separar la contribución de cada reflector se propone utilizar los efectos de paralaje sobre la ubicación de los errores producidos al medir en
distintas posiciones del plano focal. En este trabajo cada simulación se mide en 4 posiciones
distintas del plano focal.
Mediante software se generan mapas de error para los distintos escenarios. Con esto se encuentra que los errores en el reflector secundario experimentan un cambio considerablemente
mayor en su posición en la apertura, al cambiar la posición de medición en el plano focal, en
comparación con los errores en el primario.
La holografía del CCAT-p ha sido simulada satisfactoriamente y se ha identificado un comportamiento diferente entre los errores de las superficies de los reflectores.<br>QUIMAL 180004
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Herout, Jan. "Tvorba softwarové podpory metody CCPM v prostředí MS Project." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-19066.
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Project management, to which the thesis "Development of software support for CCPM method in MS Project" aims, is a very important part of everyday life for most present companies. The project management has gone through rapid development, through the second half of last century, during which many new techniques and methods, for planning and managing projects, were developed. One of these methods was critical chain project management method (CCPM), developed by E. M. Goldratt in the mid 80th of last century. At the end of the 20th century the market began to be flooded by software applications which supported project management, thanks to the boom of information and communication technologies. Because the CCPM method is still too young, there is only a very little amount of products aimed at this method. Author of the thesis took as its main objective the development of a software application that would serve to support the project management by CCPM method, and will work as an extension to an existing, widely used product, MS Project. To achieve this objective, few secondary objectives have to be met. The first is to characterize methods for project management with a focus on the critical chain project management method, including the description of the advantages and disadvantages of this method. These objectives will be achieved with the help of literature search, supplemented by knowledge gained by studying the issue at the college. Another secondary objective is to find, analyze and compare existing software used for project management support with CCPM method. For the primary analysis the author mainly uses information supplied by developers of these products, for the deeper analysis is used a model project that examines the behavior of the application in standard situations. For product comparison is made a group of criteria, which can also serve for potential readers as the basis for decision of the choice of suitable application for their needs. The main objective of the work, the development of the application, is based on the requirements set on the basis of information obtained from literature and on the results from testing of existing applications. This application is considered to be the greatest benefit of the thesis. In the end of the thesis the newly developed application is compared with existing products, by testing on a model project and by evaluating with a group of criteria established for evaluation of existing products.
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Liou, Anthony Kian-Fong. "Characterisation of the eukaryotic Chaperonin CCT." Thesis, Institute of Cancer Research (University Of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362743.
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King, Mikayala D. A. "Studies on the eukaryotic chaperonin CCT." Thesis, University of Kent, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404534.
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McEwan, Kayleigh A. "Branching out with CCTP : the synthesis of branched functional polymers." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/56271/.
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Initially the aims of this thesis were to settle conflicting literature that arose based on the consistency of results obtained from the synthesis of branched polymers, using divinyl monomer ethylene glycol dimethacrylate (EGDMA), by catalytic chain transfer polymerisation (CCTP). By polymerisation of EGDMA using a range of catalyst concentrations, and introduction of comonomers, a range of branched polymers were obtained, all of which retained high levels of vinyl functionality in the resulting products. With the increasing popularity of click chemistry, the natural progression of this work lent towards the functionalisation of these branched vinyl containing polymers by thiol- Michael addition, using a range of commercial thiols, in the creation of branched highly functional polymers, which display enhanced solution properties compared to their linear counterparts, from a small commercial monomer set. The desire to synthesise highly functional polymers led to investigation of epoxide containing monomer, glycidyl methacrylate (GMA), which has proven to be versatile to a range of functionalities. The synthesis of linear GMA homopolymers via CCTP resulted in polymers with the potential for dual functionalisation, at both epoxide and ω- unsaturated groups; to which, thiol-Michael addition and self-catalysed epoxide ringopening with amines was investigated in the synthesis of a range of functional polymers, from a single polymer precursor. Finally the copolymerisation of EGDMA and GMA via CCTP was investigated in the synthesis of branched functional polymers, whereby the level of vinyl groups retained and epoxide functionality can be tuned through monomer ratios. Site selective functionalisation of the high level of epoxide and vinyl groups was conducted using both thiol-Michael addition and self-catalysed ring-opening of epoxides with functional amines. By site selective functionalisation with both hydrophobic and hydrophilic groups, amphiphilic branched copolymers are obtained, with the potential for the synthesis of branched polymers capable of self-assembly.
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Mucino, Marco. "CCGT performance simulation and diagnostics for operations optimisation and risk management." Thesis, Cranfield University, 2007. http://hdl.handle.net/1826/2806.
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This thesis presents a techno-economic performance simulation and diagnostics
computational system for the operations optimisation and risk management of a CCGT
power station. The project objective was to provide a technological solution to a
business problem originated at the Manx Electricity Authority (MEA).
The CCGT performance simulation program was created from the integration of
existing and new performance simulation codes of the main components of a CCGT
power station using Visual Basic for Applications (VBA) in Excel ®. The
specifications of the real gas turbine (GT) engines at MEA demanded the modification
of Turbomatch, a GT performance simulation code developed at Cranfield University.
The new capabilities were successfully validated against previous work in the public
domain. In the case of the steam cycle, the model for a double pressure once-through
steam generator (OTSG) was produced. A novel approach using theoretical thermohydraulic
models for heat exchangers and empiric correlations delivered positive
results. Steamomatch, another code developed at the university, was used for the steam
turbine performance simulation. An economic module based on the practitioners’
definition for spark spread was developed. The economic module makes use of the
technical results, which are permanently accessible through the user interface of the
system. The assessment of an existing gas turbine engine performance diagnostics
system, Pythia, was made. The study tested the capabilities of the program under
different ambient and operating conditions, signal noise levels and sensor faults. A set
of guidelines aimed to increase the success rate of the diagnostic under the data and
sensor restricted scenario presented by at MEA was generated.
Once the development phase was concluded, technical and economic studies on the
particular generation schedule for a cold day of winter 2007 were conducted. Variable
ambient and operating conditions for each of the 48 time block forming the schedule
were considered. The results showed error values below the 2% band for key technical
parameters such as fuel flow, thermal efficiency and power output. On the economic
side, the study quantified the loss making operation strategy of the plant during the offpeak
market period of the day. But it also demonstrated the profit made during the peak
hours lead to an overall positive cash flow for the day.
A number of optimisation strategies to increase the profitability of the plant were
proposed highlighting the economic benefit of them. These scenarios were based on the
technical performance simulation of the plant under these specific conditions, increasing
the reliability of the study. Finally, a number of risk management strategies aimed to
protect the operations of a power generator from the main technical and economic risk
variables were outlined.
It was concluded that the use of techno-economic advanced tools such as eCCGT and
Pythia can positively affect the way an operator manages a power generation asset
through the implementation of virtually proven optimisation and risk management
strategies.
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Pan, Li. "CCGT power plant fault detection and performance analysis using statistical modelling." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534599.
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Šlejharová, Daniela. "Aplikace principů CCPM v řízení projektů IS/ICT v IT společnosti." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-75277.
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This thesis deals with application of Critical Chain in IT/ICT Project management in an international IT company. Beginning with a definition of Theory of Constraints and Critical Chain from a theoretical point of view the thesis provides knowledge base for practical implementation of Critical Chain. The thesis proceeds with selection and division of various IT/ICT projects types providing their evaluation according to their usability with CCPM (Critical Chain Project Management). The thesis also contains research and overview of available resources dealing with application of Critical Chain in IT projects management. This research is presented in a form of case studies and also concluded as a summary of both achieved successes and critical success factors that should be taken into account when implementing CCPM. Based on the knowledge acquired from the previous chapters a formal step-by-step procedure defining how to proceed with CCPM in a project was defined. This procedure will be applied in a real project management as a part of this diploma thesis. The thesis also presents analysis of currently used methodology and approaches to project management in the company and using the procedure created in the previous part the methodology is extended by relevant parts of CCPM. These approaches and methodology are formalized in a Methodical Pattern for IS Development (FI) -- CCPM and this pattern is then used for application of CCPM in a software development project. The project is prepared, planned and controlled according to principles of Critical Chain. The thesis captures this process step-by-step including monitoring of the project and its buffers. For evaluation of the Critical Chain implementation in a software development project a set of criteria was developed and used for assessment. Also every member of the given project team was sent a questionnaire to provide feedback. Originally planned comparison of the CCPM project with a project managed by currently used approaches could not, unfortunately, be carried out due to lack of data and their sensitivity. Considering the scope of this thesis, the application of CCPM in a real project represents verification of validity of the Methodical Pattern for IS Development (FI) -- CCPM and the contribution is also in creation of criteria and verification of their usability for evaluation of projects and potential comparison of two or more projects. Based on the practical application of Critical Chain in a real project, suggestions and recommendation for adjustments to current methodology and also further work with CCPM in the company were provided.
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Wünsche, Andrea [Verfasser], and Andreas [Akademischer Betreuer] Burkovski. "Identification and characterization of novel interaction partners of CcpA in Bacillus subtilis = Identifizierung und Charakterisierung neuartiger Interaktionspartner von CcpA in Bacillus subtilis / Andrea Wünsche. Betreuer: Andreas Burkovski." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1025182685/34.
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Rohman, Mattias Jan. "Biochemical characterisation of chaperonin containing TCP-1 (CCT)." Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313692.
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Cavallina, Francesco. "Progettazione elettromagnetica di un dipolo superconduttivo in configurazione CCT." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
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La tesi analizza la configurazione magnetica con avvolgimenti inclinati (CCT),presentandone le caratteristiche e le principali applicazioni, e viene svolto un lavoro di progettazione elettromagnetica nell'ambito del progetto BISCOTTO; una collaborazione tra l'università di Bologna e l'INFN di Milano e Genova. In particolare, il primo passo consiste nella realizzazione della geometria che permetterà il successivo calcolo del campo di induzione al centro del magnete. Inoltre, viene effettuato il calcolo del campo sull'asse del conduttore e sulla superficie dello stesso, utilizzando il codice numerico Mag3ds per la risoluzione. In conclusione vengono presentate le considerazioni finali alla luce del confronto con il laboratorio di Milano sui risultati ottenuti.
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Öberg, Anders. "Implementering av ISOBUS Virtual Terminal på fordonsdatorn CCP XS." Thesis, Linköping University, Department of Electrical Engineering, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5247.
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<p>Modern agriculture equipment are more computer based today, and many equipments use a terminal in the tractor where the driver have the opportunity to make adjustments to the equipment. This is the reason why ISO developed a new standard called ISOBUS. It is a communication standard based on CAN specially adapted for griculture equipments. The purpose of the standard is that it should be ossible to equip a tractor with a standard terminal called Virtual Terminal that can be used to control the equipment. The use of the terminal should be independent of the manufacturer of the tractor as well as of the equipment.</p><p>The purpose of this report is to find a solution of how to use CC Systems on-board computer, CCP XS, as a Virtual Terminal. In the report both Hardware and Software requirements have been examined, but mainly the software requirements. Only one suitable software vendor, Vector Informatik, was found after contacts with different software suppliers. It have not been possible to test this package because of the high price for the evaluation license.</p><p>A demonstration solution has also been developed in the project. It consists of a simulator program, that runs on a PC, connected to a CPP XS that executes a Virtual Terminal program. An ISOBUS compatible J1939 protocol stack from Ixxat Automation has been integrated in the Virtual Terminal program. It gives the opportunity to test the protocol stack on a CPP XS. In order to limit the size of the project, not all functions in the ISOBUS standard is implemented in the demonstration solution.</p><br><p>Moderna jordbruksredskap har blivit allt mer datoriserade och många använder sig av en terminal i traktorn där föraren har möjlighet att göra inställningar på redskapet. Därför har en standard för detta tagits fram av ISO kallad ISOBUS. Det är en kommunikationsstandard baserad på CAN speciellt framtagen för jordbruksmaskiner. Syftet med standarden är att en traktor skall kunna vara utrustad med en standardterminal kallad Virtual Terminal som används för att styra redskapen. Denna terminal skall kunna användas till samtliga redskap som kopplas till traktorn oberoende av vem som tillverkar redskapen eller traktorn.</p><p>Syftet med rapporten är att hitta en lösning för hur CC Systems fordonsdator CCP XS kan användas som en Virtual Terminal. I rapporten har dels kraven på hårdvaran undersökts men det största arbetet har lagts på att hitta en lämplig mjukvarulösning. Efter att ha kontaktat olika leverantörer av mjukvara har endast ett lämpligt mjukvarupaket hittats och det levereras av Vector Informatik. Dock har inte detta paket kunnat testas på grund av det höga priset</p><p>på en utvärderingslicens.</p><p>Det har också i projektet tagits fram en demonstrator som består av en simulator för PC som kopplas till en CCP XS som kör en Virtual Terminal mjukvara. I programvaran för Terminalen valdes en ISOBUS kompatibel J1939 protokollstack från Ixxat Automation att användas, för att få möjlighet att provköra den protokollstacken på CCP XS. För att arbetet inte skulle bli för stort har dessa programvaror begränsats till att endast stödja vissa funktioner i ISOBUSstandarden.</p>
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Altschuler, Gabriel Martin. "Protein folding studies on the actin-CCT chaperone system." Thesis, Institute of Cancer Research (University Of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440520.
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Stuart, Sarah Frances. "Kinetic studies of actin folding by the chaperonin CCT." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9702.
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The chaperonin containing TCP1 (CCT) is an essential protein in eukaryotes, and is vital for the correct folding of various obligate substrates including the cytoskeletal proteins actin and tubulin and the WD40 repeat containing proteins Cdc20 and Cdh1. CCT is highly complex and interacts with some proteins only transiently; as such the study of the mode of binding and the mechanism by which proteins are folded by the molecular chaperone is very challenging. I have used spectroscopic techniques to study the folding of Cdh1 and actin by CCT. The dimensions of CCT are such that Förster resonance energy transfer (FRET) could be used to measure distances within the complex, providing that fluorophores could be selectively introduced. Through labelling of a fragment of the WD40 propeller of Cdh1 and binding of a fluorescently labelled calmodulin (CaM) to the calmodulin binding peptide (CBP) tag introduced into two CCT subunits, it was hoped that subunits which bind to this region of Cdh1 could be identified. Following expression and purification of a stable Cdh1 fragment, methods for selective labelling of the protein were developed. The complex formed between the fluorescently labelled Cdh1 fragment, CaM and CCT was isolated by sucrose gradient. Unfortunately, no significant, reproducible FRET signal could be identified, indicating that this technique was not suited to the study of Cdh1 folding by CCT. Actin is an essential eukaryotic protein which polymerises to form filaments involved in many different cellular processes. CCT subunits which interact with actin have been identified, but the mechanism by which actin is folded is not well understood and has previously relied on the trapping of actin-CCT complexes from non-functional systems. Since the discovery of PLP2 as a cofactor involved in the actin folding process in yeast, pure in vitro actin assays have been possible. Through labelling of the C-terminus of actin with the environmentally sensitive fluorophore acrylodan, it was possible to monitor the kinetics of actin folding by CCT spectroscopically. Non-hydrolysable ATP analogues were used which allowed the identification of two separate stages in the actin folding process on CCT, an initial rearrangement of the two domains of actin followed by packing of the actin C-terminus. The importance of the actin C-terminus in actin folding and stability was highlighted by the effect of the probe with which actin was labelled on folding. The effect of mutations in CCT on the rate of actin folding was also investigated using the spectroscopic folding assay, as well as the effect of truncations of PLP2. It was found that the mutant CCTanc2, which is from a strain of yeast that produces defective actin structures and contains a mutation in subunit CCT4, behaves differently to wild type CCT at higher temperatures and concentrations of ATP. PLP2 appears to be exceptionally important for productive actin folding by CCTanc2.
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Sonoda, Yo. "Structural and functional analysis of a sporulation protein Spo0M from Bacillus subtilis." Kyoto University, 2016. http://hdl.handle.net/2433/215587.
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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19761号<br>農博第2157号<br>新制||農||1039(附属図書館)<br>学位論文||H28||N4977(農学部図書室)<br>32797<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授 三上 文三, 教授 加納 健司, 教授 喜多 恵子<br>学位規則第4条第1項該当
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Kruger, J. C. "Adaptation of Luborsky's Core Conflictual Relationship Theme (CCRT) method a phenomenological case study /." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-10222007-110453/.
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Erler, Jens [Verfasser]. "Spectro-spatial observations of galaxy clusters with Planck and CCAT-prime / Jens Erler." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1218475005/34.
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Day, Michael David. "Corpus-consulting probabilistic approach to parsing : the CCPX parser and its complementary components." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54704/.
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Corpus linguistics is now a major field in the study of language. In recent years corpora that are syntactically analysed have become available to researchers, and these clearly have great potential for use in the field of parsing natural language. This thesis describes a project that exploits this possibility. It makes four distinct contributions to these two fields. The first is an updated version of a corpus that is (a) analysed in terms of the rich syntax of Systemic Functional Grammar (SFG), and (b) annotated using the extensible Mark-up Language (XML). The second contribution is a native XML corpus database, and the third is a sophisticated corpus query tool for accessing it. The fourth contribution is a new type of parser that is both corpus-consulting and probabilistic. It draws its knowledge of syntactic probabilities from the corpus database, and it stores its working data within the database, so that it is strongly database-oriented. SFG has been widely used in natural language generation for approaching two decades, but it has been used far less frequently in parsing (the first stage in natural language understanding). Previous SFG corpus-based parsers have utilised traditional parsing algorithms, but they have experienced problems of efficiency and coverage, due to (a) the richness of the syntax and (b) the challenge of parsing unrestricted spoken and written texts. The present research overcomes these problems by introducing a new type of parsing algorithm that is 'semi-deterministic' (as human readers are), and utilises its knowledge of the rules—including probabilities—of English syntax. A language, however, is constantly evolving. New words and uses are added, while others become less frequent and drop out altogether. The new parsing system seeks to replicate this. As new sentences are parsed they are added to the corpus, and this slowly changes the frequencies of the words and the syntactic patterns. The corpus is in this sense dynamic, and so simulates a human's changing knowledge of words and syntax.
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Varga, John Joseph. "The Role of CcpA in Regulating the Carbon-Starvation Response of Clostridium perfringens." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/29759.
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Clostridium perfringens is a significant human pathogen, causing 250,000 cases of food poisoning in addition to several thousand potentially lethal cases of gas gangrene each year in the United States. Historically, work in this field has centered around toxin production, as C. perfringens can produce over 13 toxins. This work expands the knowledge of the starvation-response of C. perfringens, which includes several potential virulence factors, sporulation, motility and biofilm formation. Sporulation protects cells from a variety of stresses, including starvation. Efficient sporulation requires the transcriptional regulator CcpA, mediator of catabolite repression. Sporulation is repressed by glucose, but, surprisingly, in a CcpA-independent fashion. C. perfringens cells in a biofilm are resistant to a number of environmental stresses, including oxygen and antibiotics. Biofilm formation is repressed by glucose, and other carbohydrates, independently of CcpA. Gliding motility, a type four pili (TFP)-dependent phenomenon, affords C. perfringens with a mechanism for moving across a solid surface in response to carbohydrate starvation, while carbohydrates supplementation at high levels delay the initiation of the motility response. CcpA is required for the proper initiation of motility, a ccpA<sup>-</sup>C. perfringens strain showed a considerable increase in the time to initiation of motility on lactose and galactose, and was unable to move at all in the presence of glucose. Gliding motility represents the most significant finding of this work. TFP were previously undescribed in any Gram-positive bacterial species, and this work produced genetic evidence suggesting their presence in all members of the clostridia, and physical evidence for TFP-dependent gliding motility in a second species, C. beijerinckii.<br>Ph. D.
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Liu, Yue. "Two Dimensional PIC/MCC Simulations of RF CCPs with a Dielectric Side Wall." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066338.
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Un code de simulation de plasma à deux dimensions électrostatique à coordonnées cartésiennes Particle-in-cell/ Monte Carlo Collision (PIC/MCC) est présenté, incluant un nouveau traitement de l'équilibre des charges aux limites diélectriques. Il est utilisé pour simuler un plasma dans le gaz Ar dans un réacteur à plaques parallèles à couplage capacitif à radiofréquence a géométrie symétrique avec une paroi latérale diélectrique épaisse. La paroi latérale diélectrique protège efficacement le plasma du champ électrique augmenté au niveau de la jonction entre l'électrode alimentée et l'électrode à la masse, dont on a montré précédemment qu'elle produisait une augmentation localise de la densité de plasma. Néanmoins, un réchauffement accru des électrons est observé dans une région adjacente à la limite diélectrique, conduisant à des maxima de le taux d'ionisation, de la densité du plasma et du flux ionique vers les électrodes dans cette région. Les différents composants du chauffage électronique sont dérivés des simulations PIC/MCC et montrent que cette augmentation du chauffage électronique provient d'un chauffage ohmique accru dans la direction axiale lorsque la densité électronique diminue vers la paroi latérale. Nous avons étudié la validité de différentes formules analytiques pour estimer le chauffage ohmique en les comparant aux résultats PIC. Le chauffage des électrons à composantes x a proximité des coins a été observé aux fréquences d'excitation plus élevées, provenant d'un champ RF oscillant important dans la direction x<br>A Cartesian-coordinate two-dimensional electrostatic Particle-in-cell/Monte-Carlo Collision (PIC/MCC) plasma simulation code is presented, including a new treatment of charge balance at dielectric boundaries. It is used to simulate an Ar plasma in a symmetric radiofrequency capacitively-coupled parallel-plate reactor with a thick dielectric side-wall. The dielectric side-wall effectively shields the plasma from the enhanced electric field at the powered-grounded electrode junction, which has previously been shown to produce locally enhanced plasma density. Nevertheless, enhanced electron heating is observed in a region adjacent to the dielectric boundary, leading to maxima in ionization rate, plasma density and ion flux to the electrodes in this region. The electron heating components are derived from the PIC/MCC simulations and show that this enhanced electron heating results from increased Ohmic heating in the axial direction as the electron density decreases towards the side-wall. We investigated the validity of different analytical formulas to estimate the Ohmic heating by comparing them to the PIC results. The x component electron heating near the corners was observed at higher driving frequency, which is caused by a significant RF oscillating field in the x direction
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Choi, Young-Chool. "Privatisation of local government services : the politics of transaction cost." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242380.
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Aillaud, Chrystelle. "Modifications post-traductionnelles de la tubuline : identification des tubulines carboxypeptidases et découverte de nouveaux variants." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV049.
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Silveira, Silvana Magayevski da. "Conflitos nos relacionamentos de genitores em situação de disputa de guarda: uma contribuição para a compreensão da alienação parental." Universidade do Vale do Rio dos Sinos, 2013. http://www.repositorio.jesuita.org.br/handle/UNISINOS/4897.
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Previous issue date: 2013-08-19<br>Nenhuma<br>Esta dissertação de mestrado partiu da constatação de que existe a necessidade de um aprofundamento no estudo de situações de disputa de guarda, especialmente no que diz respeito à avaliação e intervenção em situações que implicam alienação parental. Está dividida em dois artigos. O primeiro artigo é teórico e apresenta os termos alienação parental e síndrome de alienação parental, descreve os comportamentos apresentados pelos genitores envolvidos neste tipo de configuração relacional conflitiva e revisa as discussões e estudos brasileiros sobre o tema, visando contextualizar este problema ainda pouco conhecido e estudado empiricamente. O segundo artigo é um estudo de casos múltiplos que propõe avaliar os padrões conflitivos nos relacionamentos apresentados por genitores envolvidos na alienação parental, sendo 2 alienados e 2 alienadoras. Os casos foram coletados e analisados em conformidade com o método CCRT (Core Conflictual Relationship Theme), de Lester Luborsky. Através de entrevistas, colheu-se o depoimento dos participantes sobre a separação e situação atual e obteve-se o relato de diversas situações interpessoais, o que possibilitou a obtenção do CCRT ou tema central de conflito nos relacionamentos. Os resultados indicam que o desejo principal das pessoas envolvidas na dinâmica de alienação parental é de ser amado e compreendido e que a perda deste amor seja um fator de vulnerabilidade.<br>This thesis started from the finding that there is a need for a deeper study of child custody situations, especially regarding to assessment and intervention in situations which parental alienation is involved. It is divided into two articles. The first article is theoretical and introduces he terms parental alienation and parental alienation syndrome. It describes the behavior displayed by the parents involved in this type of conflictual relationship and reviews the discussions and Brazilian studies on this issue in order to contextualize this problem still little known and empirically studied. The second article is a multiple case study that aims to evaluate standard conflicts in relationships presented by parents involved in parental alienation, being 2 alienated and 2 alienating. The cases were collected and analyzed in accordance with the method CCRT (Core Conflictual Relationship Theme) by Lester Luborsky. Through interviews, a testimony about separation and current situation of participants was collected and an account of several interpersonal situations was obtained, which allowed obtaining the CCRT or central theme of conflict in relationships. The results indicate that the main desire of the people involved in the dynamics of parental alienation is to be loved and understood and that the loss of this love is a vulnerability factor.
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Massei, Ariane Cristina. "Propriedades psicom?tricas do question?rio de relacionamento central (CRQ) em portadores de HIV/AIDS." Pontif?cia Universidade Cat?lica de Campinas, 2009. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/235.
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Previous issue date: 2009-02-27<br>Pontif?cia Universidade Cat?lica de Campinas<br>The interpersonal relationships are important facets of individuals lives, and for those who suffer from chronic diseases, the presence of relationships helps on facing the illness and acceptation of the treatment. The AIDS is an infectious disease, chronic and transmittable, caused by the HIV virus contamination. This contamination caused by AIDS brings physical consequences (lipodystrophy and metabolically disturbs, for example) and psychological ones too, such as anxiety, depression, impotence feelings and apathy, affecting specifically the relation-affective field (prejudice, rejection). The aim of study was to evaluate the psychometrical properties of the Portuguese version of the Central Relationship Questionnaire (CRQ 6.0) of HIV positive outpatients. The CRQ 6.0 is a self-report instrument, based on the Core Conflictual Relationship Theme (CCRT) whose as goal is to assess the central relationship pattern of romantic partners, according to three components: Wish (W), Responses from de Other (RO) and Responses of Self (RS). To the Valid Convergent of CRQ 6.0 study, it was used as external criteria the Symptoms Evaluation Scale (EAS-40), which evaluates psychopathological symptoms. The sample was composed of 50 individuals diagnosed with HIV(G1; 60% male; average age:41,84 years old) and 40 people accompanying other patients to the hospital (G2; 62,5% female; average age: 34 years old). As about the results, the CRQ 6.0 has presented good internal consistence, with Cronbach Alpha coefficients ranging from 0.80 to 0.87 similarly to other international researches. The CRQ 6.0 has presented as well, evidences of convergent validity, with positive and significant association between each one of the CRQ 6.0 components and factors from EAS-40 (from 0.23 to 0.57). Results pointed yet to evidences of discriminant validity of the CRQ 6.0 and EAS-40, with significant differences between G1 and G2 (Mdn from G1= 3,09; Mdn from G2= 2,78; p= 0,032) and between female and male to D from G1 (Mdn fem. = 2,43; Mdn male= 2,03; p= 0,014). Researches with large samples should be conducted .<br>Os relacionamentos interpessoais s?o parte importante da vida dos indiv?duos, e, para pessoas que sofrem de doen?as cr?nicas, a presen?a dos relacionamentos auxilia no enfrentamento da doen?a e ades?o ao tratamento. A S?ndrome da Imunodefici?ncia Adquirida (SIDA/AIDS) ? uma doen?a infecciosa, cr?nica e transmiss?vel, causada pela contamina??o pelo V?rus da Imunodefici?ncia Humana (HIV). A contamina??o pela AIDS traz conseq??ncias f?sicas (lipodistrofia e disturbios metab?licos, por exemplo) e psicol?gicas, como ansiedade, depress?o, sentimentos de impot?ncia e apatia, afetando especificamente no campo afetivo-relacional (preconceito, rejei??o).O estudo teve como objetivo avaliar as qualidades psicom?tricas da vers?o em portugu?s do Question?rio de Relacionamento Central (CRQ 6.0) junto a pacientes HIV positivos, em tratamento ambulatorial. O CRQ 6.0 ? um instrumento de auto-relato, baseado no m?todo Tema Central de Relacionamento Conflituoso (CCRT) que tem como objetivo identificar o padr?o de relacionamento central de parceiros amorosos, de acordo tr?s componentes: Desejo (D), Respostas do Outro (RO) e Respostas do Eu (RE). Para o estudo de validade convergente do CRQ 6.0, foi utilizado como crit?rio externo a Escala de Avalia??o de Sintomas (EAS-40), que avalia sintomas psicopatol?gicos. A amostra foi composta por 50 indiv?duos com diagn?stico de HIV (G1; 60 % do g?nero masculino; idade m?dia de 41,84 anos) e 40 acompanhantes de pacientes de outras enfermarias (G2; 62,5% do g?nero feminino; idade m?dia de 34 anos). Quanto aos resultados, o CRQ 6.0 apresentou boa consist?ncia interna, com coeficientes de alfas de Cronbach variando de 0,80 a 0,87 semelhantes aos dados encontrados em outras pesquisas internacionais. Apresentou tamb?m evid?ncias de validade convergente, com associa??es positivas e significantes entre alguns componentes do CRQ 6.0 e fatores da EAS-40 (de 0,23 a 0,57). Os resultados apontam ainda para evid?ncias de validade discriminante do CRQ 6.0 e EAS-40, com diferen?as significantes nos escores entre G1 e G2 para o componente RE (Mdn do G1= 3,09; Mdn do G2= 2,78; p= 0,032) e entre sexo feminino e masculino para D do G1 (Mdn do sexo fem. = 2,43; Mdn do sexo masc.= 2,03; p= 0,014). Pesquisas com amostras maiores devem ser realizadas.
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Steinert, Nadine [Verfasser], and Andreas [Akademischer Betreuer] Burkovski. "Quantitative und qualitative Analyse der Transkription CcpA-regulierter Gene / Nadine Steinert. Betreuer: Andreas Burkovski." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1022002163/34.
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Almeida, Ilton Marchi de [UNESP]. "Proposta de uso integrado dos métodos Scrum e CCPM na gestão de múltiplos projetos." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151169.
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Previous issue date: 2017-06-30<br>A Gestão de Projetos (GP) ganhou papel de destaque na viabilidade dos objetivos estratégicos das organizações. O desenvolvimento de produtos e serviços vem recebendo forte pressão do mercado, demandante de lançamentos frequentes e em prazos cada vez menores. Para atender estas novas exigências, a GP deve prover informações úteis para tomadas de decisões em ambientes de múltiplos e complexos projetos, sujeitos a relevantes incertezas e volatilidade. Considerando as oportunidades de melhoria das práticas da GP para lidar com este ambiente instável e ambíguo, o objetivo deste trabalho é propor, utilizando o método de Teoria Fundamentada em Dados (TFD), um framework que prescreva como aplicar de forma combinada dois métodos de GP: a Gestão de Projetos por Corrente Crítica (Critical Chain Project Management - CCPM) e o Scrum. Os resultados obtidos por este trabalho apontam que a integração destes métodos pode potencializar os benefícios e atenuar as fragilidades de cada uma delas em particular, e cujo uso articulado e coordenado pode permitir decisões mais efetivas em ambientes voláteis, incertos, complexos e ambíguos (VUCA - Volatility, Uncertainty, Complexity and Ambiguity) de múltiplos projetos.<br>Project Management (PM) has gained a major role in the viability of the strategic objectives of organizations. The development of products and services has been under stronger market pressure, requesting frequent releases and in ever-shorter periods. To meet these new requirements, initiatives for maintaining PM as an information provider to make decisions in multiple and complex projects, exposed to relevant uncertainty and volatility, should be sought. Regarding the opportunities for improvement of PM practices to deal with this unstable and ambiguous environment, the objective of this work is to propose, using the Grounded Theory (GT) method, a framework that prescribes how to apply two GP methods in combination: the Critical Chain Project Management - CCPM and Scrum. The results of this work indicate that the integration of these methodologies can enhance the benefits and mitigate the weaknesses of each of them in particular. This hybrid model could permit a better articulation and coordination of the project tasks, allowing effective decisions in multiple project environments affected by volatility, uncertainty, complexity and ambiguity (VUCA).
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Almeida, Ilton Marchi de. "Proposta de uso integrado dos métodos Scrum e CCPM na gestão de múltiplos projetos /." Bauru, 2017. http://hdl.handle.net/11449/151169.
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Orientador: Fernando Bernardi de Souza<br>Banca: Jose de Souza Rodrigues<br>Banca: Robert Eduardo Cooper Ordoñez<br>Resumo: A Gestão de Projetos (GP) ganhou papel de destaque na viabilidade dos objetivos estratégicos das organizações. O desenvolvimento de produtos e serviços vem recebendo forte pressão do mercado, demandante de lançamentos frequentes e em prazos cada vez menores. Para atender estas novas exigências, a GP deve prover informações úteis para tomadas de decisões em ambientes de múltiplos e complexos projetos, sujeitos a relevantes incertezas e volatilidade. Considerando as oportunidades de melhoria das práticas da GP para lidar com este ambiente instável e ambíguo, o objetivo deste trabalho é propor, utilizando o método de Teoria Fundamentada em Dados (TFD), um framework que prescreva como aplicar de forma combinada dois métodos de GP: a Gestão de Projetos por Corrente Crítica (Critical Chain Project Management - CCPM) e o Scrum. Os resultados obtidos por este trabalho apontam que a integração destes métodos pode potencializar os benefícios e atenuar as fragilidades de cada uma delas em particular, e cujo uso articulado e coordenado pode permitir decisões mais efetivas em ambientes voláteis, incertos, complexos e ambíguos (VUCA - Volatility, Uncertainty, Complexity and Ambiguity) de múltiplos projetos.<br>Abstract: Project Management (PM) has gained a major role in the viability of the strategic objectives of organizations. The development of products and services has been under stronger market pressure, requesting frequent releases and in ever-shorter periods. To meet these new requirements, initiatives for maintaining PM as an information provider to make decisions in multiple and complex projects, exposed to relevant uncertainty and volatility, should be sought. Regarding the opportunities for improvement of PM practices to deal with this unstable and ambiguous environment, the objective of this work is to propose, using the Grounded Theory (GT) method, a framework that prescribes how to apply two GP methods in combination: the Critical Chain Project Management - CCPM and Scrum. The results of this work indicate that the integration of these methodologies can enhance the benefits and mitigate the weaknesses of each of them in particular. This hybrid model could permit a better articulation and coordination of the project tasks, allowing effective decisions in multiple project environments affected by volatility, uncertainty, complexity and ambiguity (VUCA).<br>Mestre
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Hanna, Melissa. "Decision-making processes and experiences of older people using the Beating the Blues computerised cognitive behavioural self-help programme : a qualitative study." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7801.
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Introduction: Current recommendations by National Institute of Clinical Excellence (Technology Appraisal 51) emphasise the need for future research to examine the effectiveness of CCBT across the age span. Kaltenthaler et al. (2008) recommended future research focuses on acceptability of CCBT through using ‘survey and intensive qualitative methods, include the process of initial engagement, continuation versus drop-out, and in those completing, satisfaction or regret undertaking CCBT’ (p.1528). The pilot study by McMurchie (2011) was the first to explore the acceptability and effectiveness of the CCBT package Beating the Blues (BTB) solely with older people. Using qualitative methodology, the aim of the current study was to explore the experiences of older people who, when participating in the pilot study chose to use BTB compared to those who chose to remain with their treatment as usual (TAU). The current study aimed to gain a deeper understanding of the acceptability of BTB as well as factors that influence decisionmaking in terms of uptake to BTB and discontinuation from BTB. Method: Individual semi-structured interviews were carried out with 20 older people who took part in the pilot study (McMurchie, 2011). Participants were in one of three groups, these were: BTB-completers, BTB-discontinuers and TAU. Transcripts were analysed using Interpretative Phenomenological Analysis (IPA) (Smith et al., 2009). Findings: Five master themes emerged from the interviews: Beating the Blues as a Process of Change; Relevance of Beating the Blues to Older People; Challenges of Using Beating the Blues; Motivation to Try Something New and Barriers to Beating the Blues at Time of Uptake. Conclusions: Overall, the master themes reflected the experiences of either “regaining control” or a sense of “hopelessness” when opting whether or not to use BTB in the first instance and to then continue with the treatment. Experiences of using BTB appeared to be linked to the outlook participants had about using a novel treatment with either a sense of hope or impending failure. Participants who chose BTB had a more positive outlook which impacted their ability to manage perceived challenges and work towards recovery. The sense of impending failure seemed to be linked to participants perceiving more barriers to using BTB and struggling to overcome these challenges, resulting in them either declining BTB or feeling they were not benefiting from BTB and therefore discontinuing it.
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Marques, Joaquim. "Código dos contratos públicos (CCP): Modelo de aprovisionamento para a GNR." Master's thesis, Academia Militar. Direção de Ensino, 2009. http://hdl.handle.net/10400.26/8087.
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Este trabalho de Investigação Aplicada subordina-se ao tema: “Código dos Contratos Públicos (CCP) – Modelo de Aprovisionamento para a GNR”, sendo esta uma temática muito recente e de enorme importância para a GNR.
O CCP foi aprovado pelo Decreto-Lei nº 18/2008 de 19 de Janeiro, que regula a disciplina aplicável à contratação pública e o regime substantivo dos contratos públicos que revistam a natureza de contrato administrativo.
Os objectivos gerais deste trabalho baseiam-se na análise à questão central que se pretende investigar e que incide no estudo das implicações do novo Código dos Contratos Públicos no Modelo de Aprovisionamento da GNR.
O presente trabalho encontra-se dividido em duas partes distintas. A primeira parte tem um cariz essencialmente teórico, baseado num estudo minucioso de obras literárias, estudos e publicações de diversos autores, em que vão ser abordadas questões relacionadas com o assunto em análise.
A segunda parte incide essencialmente numa vertente mais prática, onde se analisam os
dados recolhidos nos inquéritos e nas entrevistas realizadas e se apresentam as principais conclusões de modo a que se confirmem as hipóteses formuladas, dando resposta às perguntas de investigação que constituem o objecto de estudo.
Tendo em conta a análise dos dados recolhidos, conclui-se que esta nova legislação traz vantagens significativas. Contudo, para que isto se verifique, a GNR tem que ultrapassar uma série de dificuldades e garantir os pressupostos necessários e indispensáveis para toda a optimização do processo de aquisição de bens e serviços.<br>Abstract This work of applied investigation is subordinated to the theme of: “The Public Contracts
Code – Supply Chain Model for the GNR”. This is a very new and greatly important theme for the GNR.
The CCP was approved by the Decreto-Lei nº 18/2008 that regulates the applicable law to
public contracts and the substantive regime of public contracts that have the nature of na administrative contract.
The main objectives of this work are based on the analysis of the central question that I wish to investigate, which is the study of the implications of the new Public Contracts Code on the Supply Chain Model of the GNR.
This work is divided in two separate parts. The first as an essentially theoretical approach, based on a thorough study of literary works, studies and publications of several authors with which I will face the different aspects related to my analysis.
The second part has a more practical approach and the analyse of the data gathered in the enquires and interviews made and where are presented the main conclusions in a way that may confirm the formulated hypothesis, giving answers to the investigation questions that are the objective of this study.
As far as the data gathered is concerned, the main conclusion is that this new legislation brings a whole new set of significant advantages. Yet, for all this to happen, the GNR must surpass a lot of difficulties and ensure a set of presuppositions that are needed and indispensable for the optimization of the entire process of goods and services acquisition.
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Seaby, Thomas David. "Single molecule studies on actin folding by the eukaryotic chaperonin CCT." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/25137.
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The eukaryotic, cytosolic chaperonin containing TCP-1 (CCT) is a protein folding nanomachine. CCT is a 1 MDa double-ring-structured ATPase which assists nascent polypeptides to reach their native conformational state. Obligate substrates include the cytoskeletal components actin and tubulin. Whilst significant structural studies have been conducted, relatively little is known about the dynamics of the ATP-dependent folding process. Total Internal Reflection Fluorescence (TIRF) microscopy is a high signal to noise, single molecule, microscopy technique which has been previously used to observe both protein dynamics and extract enzyme kinetics at the single molecule level. We have immobilised functional CCT onto silica surfaces in order to extract dwell times and kinetics of the folding process, as CCT captures, folds and releases actin from its unfolded state to the folded G-actin monomer. A method for the immobilisation of CCT, via a calmodulin protein, has been developed. Mutant CCT-6CBP has a calmodulin binding peptide tag inserted into the apical domain of the CCT6 subunit and can be affinity captured via calmodulin immobilised to a borosilicate surface. The calmodulin-CCT interaction is calcium dependent and can be reversed allowing for discrimination between specific versus non-specific binding. ATP-dependent release of unfolded actin from CCT complexes immobilised to silica surfaces has proven to be problematic. Complexes can be specifically bound but subsequently seem to lose functional folding behaviour. Attempts to count the numbers of the stimulatory cofactor phosducin-like protein 2 (PLP2) and actin monomers bound to the CCT complex, utilising photobleaching, is described. A program for the analysis of single molecule traces was written. Incorporating a Chung-Kennedy non-linear filter, this program provides stoichiometric data consistent with spectrophotometric methods. Analysis of CCT-actin-PLP2 complexes was not possible due to time constraints.
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Nikjoo, Soukhtabandani Ali. "Partial shape matching using CCP map and weighted graph transformation matching." Thesis, Université Laval, 2014. http://www.theses.ulaval.ca/2014/30611/30611.pdf.
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La détection de la similarité ou de la différence entre les images et leur mise en correspondance sont des problèmes fondamentaux dans le traitement de l'image. Pour résoudre ces problèmes, on utilise, dans la littérature, différents algorithmes d'appariement. Malgré leur nouveauté, ces algorithmes sont pour la plupart inefficaces et ne peuvent pas fonctionner correctement dans les situations d’images bruitées. Dans ce mémoire, nous résolvons la plupart des problèmes de ces méthodes en utilisant un algorithme fiable pour segmenter la carte des contours image, appelée carte des CCPs, et une nouvelle méthode d'appariement. Dans notre algorithme, nous utilisons un descripteur local qui est rapide à calculer, est invariant aux transformations affines et est fiable pour des objets non rigides et des situations d’occultation. Après avoir trouvé le meilleur appariement pour chaque contour, nous devons vérifier si ces derniers sont correctement appariés. Pour ce faire, nous utilisons l'approche « Weighted Graph Transformation Matching » (WGTM), qui est capable d'éliminer les appariements aberrants en fonction de leur proximité et de leurs relations géométriques. WGTM fonctionne correctement pour les objets à la fois rigides et non rigides et est robuste aux distorsions importantes. Pour évaluer notre méthode, le jeu de données ETHZ comportant cinq classes différentes d'objets (bouteilles, cygnes, tasses, girafes, logos Apple) est utilisé. Enfin, notre méthode est comparée à plusieurs méthodes célèbres proposées par d'autres chercheurs dans la littérature. Bien que notre méthode donne un résultat comparable à celui des méthodes de référence en termes du rappel et de la précision de localisation des frontières, elle améliore significativement la précision moyenne pour toutes les catégories du jeu de données ETHZ.<br>Matching and detecting similarity or dissimilarity between images is a fundamental problem in image processing. Different matching algorithms are used in literature to solve this fundamental problem. Despite their novelty, these algorithms are mostly inefficient and cannot perform properly in noisy situations. In this thesis, we solve most of the problems of previous methods by using a reliable algorithm for segmenting image contour map, called CCP Map, and a new matching method. In our algorithm, we use a local shape descriptor that is very fast, invariant to affine transform, and robust for dealing with non-rigid objects and occlusion. After finding the best match for the contours, we need to verify if they are correctly matched. For this matter, we use the Weighted Graph Transformation Matching (WGTM) approach, which is capable of removing outliers based on their adjacency and geometrical relationships. WGTM works properly for both rigid and non-rigid objects and is robust to high order distortions. For evaluating our method, the ETHZ dataset including five diverse classes of objects (bottles, swans, mugs, giraffes, apple-logos) is used. Finally, our method is compared to several famous methods proposed by other researchers in the literature. While our method shows a comparable result to other benchmarks in terms of recall and the precision of boundary localization, it significantly improves the average precision for all of the categories in the ETHZ dataset.
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Tensmeyer, Nicole C. "The Role of the Chaperone CCT in Assembling Cell Signaling Complexes." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/9192.
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In order to function, proteins must be folded into their native shape. While this can sometimes occur spontaneously, the process can be hindered by thermodynamic barriers, trapped intermediates, and aggregation prone hydrophobic interactions. Molecular chaperones are proteins that help client proteins or substrates overcome these barriers so that they can be folded properly. One such chaperone is the chaperonin CCT, a large MDa protein made up of 16 paralogous subunits that form a double ring structure. CCT encapsulates its substrates in a central cavity, where they are sequestered and folded, using ATP binding and hydrolysis to drive conformational changes in the CCT-substrate complex. CCT mediates the folding of many substrates involved in a variety of cellular process, including the cytoskeletal proteins actin and tubulin, and the G protein subunit Gabg, which signals downstream of GPCRs in a variety of cellular processes. We showed that CCT is responsible for folding the b-propeller containing proteins, mLST8 and Raptor, which are subunits of the mTOR complexes. The mTOR complexes (mTORC1 and mTORC2) are master regulators of cell growth and survival by controlling processes such as protein synthesis, energy metabolism, cell survival pathways and autophagy. CCT folds mLST8 and Raptor and help them assemble into the mTOR complexes. As a result, CCT is required for functional mTOR signaling. Furthermore, we solved a 4.0 Ǻ resolution structure of mLST8 bound to CCT. Surprisingly, mLST8 is found in the center of the folding cavity, in between the rings, despite previous evidence suggesting that substrates bind only in the apical domains. Given its role in folding and assembling the mTOR complexes, G proteins, and many other proteins involved in cell survival pathways, CCT has been implicated in cancer. CCT upregulation often correlates with a worse prognosis, likely because uncontrolled growth requires increased chaperone capacity. The peptide CT20P has been shown to have cytotoxic effects in cancer cells, likely through its binding to CCT. We characterized CT20P, showing that it binds to CCT and inhibits its substrate-folding functions in cells. We specifically showed that a GFP-CT20P fusion protein inhibited the assembly of two important signaling complexes Gbg and mTORC1. These results show that CT20P is a useful inhibitor for the study of CCT function.
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Tu, Wei. "Evaluation of Full-Scale CCP Pavement Performance Using Accelerated Loading Facility." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1420638991.
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Lowe, Samuel. "Branched polymers via CCTP with vinyl end groups and their application in wound care materials." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/93321/.
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Chronic wounds represent a significant problem to healthcare systems globally, wound generated from burns and diabetic ulcers have a 20 % chance of becoming chronic. In this thesis work was conducted to try and develop novel networks to act as chronic wound treatment systems. Initially Catalytic Chain Transfer Polymerization (CCTP) was utilized to develop low molecular weight branched polymers with ω-vinyl end groups for use as novel gelators. Poly(methacrylic acid) (pMAA) was chosen as a building block due to its anionic nature and possibilities in the region of drug delivery and wound care. Branched acidic polymers of different molecular weights and degrees of branching were synthesized with good control. In addition to this branched and linear species of poly[(polyethylene glycol) methyl ether methacrylate] pPEGMEMA were synthesized by the same technique. All polymers were investigated kinetically and with multi-detector SEC to determine branching. A poly(2-hydroxyethyl acrylate) hydrogel system was optimized by both thermal and photo initiation prior to the addition of branched acid polymers. Branched acid polymers exhibited a hardening effect upon thermally cured gels by rheology with a corresponding decrease in swelling suggesting reduction in the mesh size due to acting as gelators. However, in a photo-cure system the reverse effect was observed with softening and increase in swelling signifying an increase in mesh size. A poly(2-acrylamido-2-methylpropane sulfonic acid) (pAMPS) hydrogel system was then utilized to study this effect with different degrees of branching and molecular weights of polymers. Studies by rheology, swelling and compression indicate that the branched acid polymers were exhibiting a chain transfer effect from the ω-vinyl end group, inhibiting gel formation and therefore rendering them unsuitable for use as gelators. An inter-penetrating network (IPN) of pAMPS and a thermoplastic elastomer (TPU) was formed by photo-curing a TPU film swollen in a solution of AMPS monomer and initiator. This process yielded a versatile, highly absorbent and transparent network which was able to rapidly absorb large quantities of fluids. Calcium testing and adhesion testing showthat this material has significant potential in the field of wound dressings.
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Du, Eliane. "Factors that impact on the usability of computerised cognitive behavioural therapy (CCBT) : mixed methods studies." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/22999.
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Computerised Cognitive Behavioural Therapy (CCBT) has been recommended for patients in the National Health Service (NHS) Primary Care across the United Kingdom for management of mild to moderate anxiety and depression. This approach also promises financial savings, and may fill the gap between demand and supply of face-to-face therapy. Studies have shown that CCBT is feasible and effective. However, dropout rates can be as high as 86%, but the reasons remain unclear and the information available is limited. This thesis explores factors that may impact on the usability and user experience of this computer-mediated therapy. Espousing the “real world” research philosophy and widely used methods in the Human-Computer Interaction (HCI) field for usability evaluations, four studies using a mixed-methods design were conducted. Study I was an online usability survey, which investigated if usability evaluations had been conducted for CCBT applications. Two versions of questionnaires were sent to four CCBT software developers and ten authors of randomised controlled trials. The categories and responses of the questionnaires gathered from five respondents were reviewed and summarised. The findings suggested that usability evaluations for CCBT were still in their infancy when compared to other healthcare interventions to which HCI approaches have been widely applied. Study II was a usability Heuristic Evaluation (HE) conducted with four expert evaluators to assess two different CCBT applications’ interfaces (MoodGYM and Living Life to the Full) against the self-designed usability heuristics for their compliance. The findings revealed numerous usability issues. Major problems related to navigation and inconsistency of the interfaces were identified. These could be rectified to enhance the user experience. Study III focused on other factors besides usability that might have an influence on the effective use of CCBT. Perceptions of service providers who were involved in both decision-making about CCBT availability and supporting its use were gathered. Nine service providers at different NHS organisations were interviewed. The interviews were analysed using techniques from Grounded Theory (GT). The findings suggested that the practitioners’ attitudes towards CCBT might have affected its service delivery. Four categories from the data analysis were identified: (1) shaping behaviour, (2) implementing and delivering, (3) making an appropriate referral, and (4) technology/CCBT packages - advancing with time. A conceptual model was also generated, “building support around CCBT”: a road-map that could address some of these issues. Study IV examined patients’ perceptions and acceptance of a CCBT application (Beating the Blues), its usability and the user experience, and also whether the user characteristics (e.g. computer experience (CE) and computer self-efficacy (CSE)) had any influence on patients’ use of this technology. A mixed-methods approach was utilised with a sample of 33 participants. Face-to-face and email interviews were conducted. Feedback was also gathered from a usability questionnaire and think-aloud protocol with seven participants selected from the sample. The data were analysed using Thematic and Saliency Analysis to uncover themes. Descriptive statistics were used to describe data from questionnaires. Two overarching themes from the interviews were identified: (1) access to CCBT services, and (2) perceptions and attitudes towards CCBT. Both themes revealed issues which might have significantly impacted on patients’ engagement with CCBT. Numerous flaws were also discovered in the application’s design and functionality (e.g. navigation, aesthetics, relevance of content, and inflexibility). However, the results from CE and CSE questionnaires suggested that participants were confident in using this technology. The four studies provided an in-depth understanding of factors that affect the usability and user experience of CCBT and possible reasons for the high attrition rates. The implications of this research point to the need for health policymakers to focus on the current implementation issues and on how best to deploy this treatment therapy to patients. Further development of CCBT is pivotal to its success, in particular, expanding contexts of use and increasing usability evaluations. Keeping users interested and engaged will improve treatment efficiency, completion rates and will achieve better clinical outcomes.
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Curto, Rita de Cássia Siqueira. "Estudo comparativo entre duas cepas de Saccharomyces cerevisiae CCT 1530 e CCT 1531 para a produção de proteínas unicelulares a partir de hidrolisado de amido de mandioca /." reponame:Repositório Institucional da UFSC, 1998. http://repositorio.ufsc.br/xmlui/handle/123456789/77994.
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Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.<br>Made available in DSpace on 2012-10-17T09:23:06Z (GMT). No. of bitstreams: 0Bitstream added on 2016-01-08T23:25:19Z : No. of bitstreams: 1
137698.pdf: 29310314 bytes, checksum: 914f12035ecedbbf41bf1c8ffe85a7b5 (MD5)
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Fu, Jiabin. "Challenges to increased use of coal combustion products in China." Thesis, Linköping University, Environmental Technique and Management, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-57248.
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<p>Electricity accounts for much of the primary energy used in China, and more thanthree-quarter of the total electricity is generated by coal combustion. Coal burningcombined with flue gas cleaning system generates large quantity of coal combustionproducts (CCPs), which has caused significant environmental and economic burden tothe economy, ecology and society. Of great importance are thus different applicationswhich contribute to the increased use of CCPs. This thesis looks at an overview ofCCPs production and utilization all around the world and investigates current CCPsapplications as well as potential technically sound and economically justifiedtechnologies. Results of this thesis show that CCPs utilization rate in differentcountries varies widely from 13% to 97%. Worldwide, a significant proportion ofCCPs from the main producers, e.g. China, the United States and India, is still beingdisposed off, resulting in a low-level of overall utilization of these products. It isevident that the amount of CCPs produced substantially exceeds consumptionsbecause of various existing obstacles and limitations. In order to formulate effectiveapproaches, identifying challenges to increased use of CCPs is of great weight. The aimof this thesis is to analyze current and potential utilizations of CCPs and morespecifically address factors that inhibit or promote the use of CCPs from coal-firedpower plants in China.</p><p>Savings of natural resources, energy, emissions of pollutants, GHG emissions anduseful land were found as the major incentives for CCPs utilization. In China, a ban ofsolid clay bricks was also found to be a very powerful measure to stimulate thedevelopment of other by-product based wall materials while saving useful land andprotecting the environment. However, this strong support from the government hasnot been fully implemented, which seriously hampered CCPs uses. Results presentedin this thesis also show that high transportation cost of low unit-value CCPs,competition from available natural materials and spatial variation in supply-demandposes three of the most important barriers to the increased use of CCPs in China.Industrial organizations with assistances from the government have shown to be offundamental importance for formulating approaches to take in overcoming thebarriers.</p><p>This thesis emphasized that transforming laboratory- and pilot-scale technologies intocommercial productivity is of the highest priority for increased use of CCPs. Aconceptual model of CCPs Eco-Industry Park (EIP) as a potential effective solutionwas proposed. Mutual economic and environmental benefits can be achieved throughthe collaboration between different industries in the CCPs EIP. And other feasiblerecommendations of initiatives from both the government and industries were alsodiscussed.</p>
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Kuang, Yin. "Generation of TTT and CCT curves for cast Ti-6Al-4V alloy." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004560.
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Kane, Michael J. "The management of change in Scottish Local Authorities : the experience of CCT." Thesis, Glasgow Caledonian University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320701.
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Konan, N'Zi André. "Estudo farmacognóstico e toxicológico de Anacardium occidentale Linn. (Anacardiaceae) Clone CCP-76." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-01082017-145620/.
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Os extratos totais, assim como os compostos fenólicos isolados de diferentes partes de Anacardium occidentale conhecido popularmente no Brasil como cajueiro mostraram atividades antiúlcera e antibacteriana. O objetivo deste trabalho foi a verificação destas atividades nas folhas, estudo farmacobotânico, químico e toxicológico. Para a analise anatômica foram utilizados cortes do terço mediano inferior da lâmina fotiar. Nesta, as epidermes em vista frontal apresentam cutícula estriada, na face abaxial, a epiderme é constituída de células de formato poligonal, com paredes bem justapostas. Na face adaxial, as células são de paredes espessas, ligeiramente onduladas. A mesma é constituída de estômatos de tipo anomocítico e de tricomas glandulares de forma ovóide. O mesófilo é constituído de duas camadas de parênquima paliçádico, espessas, de forma quase regular e de parênquima lacunoso com células de forma irregular, envolvendo os feixes vasculares de nervuras secundarias. Extensões de fibras são observadas no mesófilo. A nervura mediana possui um colênquima desenvolvido e ductos são encontrados no floema assim como no parênquima medular. Drusas são encontradas no parênquima lacunoso assim como no parênquima fundamental e no colênquima. A partir da triagem fitoquímica, da cromatografia em camada delgada, cromatografia liquida de alta eficiência e cromatografia liquida acoplada a espectrometria de massa, verificou-se a presença nas folhas de cajueiro de compostos polifenólicos, particularmente de heterosídeos flavonóidicos. As estruturas de flavonóide que parecem ser mais evidentes, de acordo com a cromatografia liquida acoplada a massa, são principalmente os heterosídeos da quercetina. O extrato etanol 70% liofilizado das folhas do cajueiro foi submetido ao modelo agudo da úlcera gástrica em ratos e a ensaio antibacteriano, ensaiando as linhagens de Staphylococcus aureus ATCC 25923, Escheríchía coli ATCC 35218 e ATCC 25922, Pseudomonas aerugínosa ATCC 27853 e de Campylobacter coli. Na úlcera aguda, a área relativa de lesão ulcerativa foi diminuída de 98% na dose 400mg/kg, em relação ao controle. A partir de um estudo de doses crescentes sobre a inibição de úlcera, a DE50 foi calculada como 150 mg/kg e as doses de extrato maiores ou iguais a 100 mg/kg exibiram uma inibição de lesão ulcerativa melhor que o lansoprazol 30mg. A fração metanólica, que inibiu as ulcerações de 88,20%, deve conter alguns dos princípios ativos da atividade antiúlcera. Quanto ao teste antimicrobiano, foram obtidas concentrações inibitória mínima e bactericida mínima, iguais a 320 µg/mL, particularmente com a linhagem Staphylococcus aureus, a partir do extrato bruto e da sua fração rica em flavonóides. A partir de ensaio de toxicidade aguda em camundongos e ratos, a DL50 do extrato bruto foi considerada superior a 2000 mg/kg. Foi feito um estudo de toxicidade de administração reiterada em 30 e 90 dias. Baseados em analises bioquímicas para avaliação da função renal e da função hepato-biliar, os parâmetros uréia, creatinina, transaminases, proteína total, albumina, colesterol e cálcio tendem a comprovar que o produto é bem tolerado pelo organismo dos ratos. Este fato é também confirmado pelo estudo hematológico e pela histopatologia, não ocorrendo alterações, após administração subaguda do extrato em ratos. O potencial mutagênico foi avaliado através do teste de Ames e do teste do micronúcleo de medula óssea em camundongo. Foi obtido indício de indução de \"frameshift\" e substituição de pares de bases. Na dose de 2000mg/kg, o extrato de cajueiro parece induzir danos nos cromossomos porém, o fenômeno parece ser extremamente inferior (p<0,001) ao efeito clastogênico induzido pela ciclofosfamida, utilizada como agente mutagênico de referência.<br>Crude extracts as well as phenolics isolated from the bark or the fruit of Anacardium occidentale popularly known as cajueiro in Brazil, showed antiulcer and antibacterial effects. The aim of this work was to verify those effects in the leaf, botanical, chemical and toxicological studies. Ultrastructure of the leaf was carried on. Cross-sections from the third inferior part of the leaf blade were used. Cashew leaf contains uniseriate epidermis with a sub-eperdimic layer, anomocytic stomata and glandular ovoid trichomes on the inferior surface. The mesophyll exhibits two cell layers of palisadic parenchyma and a lacunose parenchyma containing vascular bundles of the secondary nervures. The median nervure contains a developed collenchyma. Several druses of calcium oxalate are present in the fundamental parenchyma, lacunose parenchyma and in the collenchyma. Resin ducts are also observed in the phloem as well as in the medullar parenchyma. Extensions of sclerenchymatous fibres are observed in the mesophyll. By phytochemical analyses using TLC, HPLC-DAD and positive ions LC-ESIMS, we verified the presence of polyphenols in cashew leaves particularly heterosids of flavonoids. From LC-ESI-MS, evident structures of flavonoids seemed to be heterosids of quercetin. Ethanol 70% extract of cashew leaves was used for antiulcer and antibacterial essays. With extract dose 400mg/kg, ulcer lesions induced by HCL/ethanol 60% in rats, decreased about 98%. By a dose-response effect study, ED50 was evaluated about 150 mg/kg. Extract doses higher than 100mg/kg showed potential of lesion inhibition superior to lansoprazol 30mg. Extract methanolic fraction that gave 88,20% of ulcer inhibition likely contains the principie active of the antiulcer effect. Using bacterial strains, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218 and ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and a clinical isolate Campylobacter coli, for antibacterial essay, the ethanolic extract and one fraction rich in flavonoids were only active in S. aureus with MIC and MBC equal to 320 µg/mL. Acute, 30-day and 90-day subacute toxicity studies were carried out. Crude extract DL50 was superior to 2000mg/kg. Based on biochemical analyses for the evaluation of renal and hepato-biliary functions, level of urea, creatinine, transaminases, total protein, albumin, bilirubin, cholesterol and calcium proved that the extract is biologically tolerated by rat organismo This result was also confirmed by studies in hematology and histopathology. Genotoxity was accessed by Ames test in Salmonella typhimurium strains TA97, TA98, TA100, TA102 and bone marrow micronucleus test in mice. The extract exhibited sign of frameshift and base pairs substitution. Extract dose 2000mglkg seemed to induce damage in the chromosomes however; the activity was extremely inferior to the c1astogenic effect induced by ciclophosphamide.
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Dionello, Carla da Fontoura. "Manifestações reumatológicas, fator reumatóide e anticorpos anti CCP em pacientes com Hanseníase." reponame:Repositório Institucional da UFPR, 2009. http://hdl.handle.net/1884/17858.
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Blanchin, Stéphanie. "La thyroperoxydase humaine : rôle du module CCP-like dans l'auto-immunité thyroi͏̈dienne." Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX22052.
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