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Dissertations / Theses on the topic 'CCR3'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Duchesnes, Cecile Emmanuelle. "Molecular characterisation of the chemokine receptor CCR3." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407171.

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2

Brasseit, Jennifer. "Mutagenese und funktionelle Charakterisierung des humanen CCR3-Rezeptors." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-61848.

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3

Joubert, Philippe. "Expression and function of chemokine receptors on airway smooth muscle cells." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103385.

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Asthma is a respiratory disease that affects 2.5-3 million Canadians. This condition is characterized by a Th2-driven immune response that implicates the infiltration of eosinophils and remodelling of the airways. In the last decade, airway smooth muscle cells (ASMC) have became the subject of intense research in the field of inflammatory lung diseases including asthma. It is known that ASMC respond to a wide variety of inflammatory mediators such as cytokines and chemokines. Function of ASMC in the context of asthma has extended beyond its traditional role of a structural cell. Indeed, it is

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4

Fulkerson, Patricia C. "A Critical Role for Eosinophils and CCR3 Signal Transduction in Allergic Airway Disease." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1120337075.

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5

Hablot, Julie. "Liens entre inflammations articulaire et digestive : étude expérimentale chez la souris et contribution de l’immunité mucosale." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0095/document.

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Des cellules immunitaires appartenant à l’immunité de type 3 sont localisées dans muqueuse digestive. Les micro-organismes du microbiote stimulent le système immunitaire pour le maintenir en veille face à de potentiels agents infectieux, tout en ayant une tolérance pour les micro-organismes commensaux. Des études montrent des anomalies du microbiote intestinal chez les patients arthritiques. Ceci suggère une dérégulation de l’immunité mucosale digestive dans la survenue de l’inflammation articulaire. Des cellules de l’immunité mucosale pourraient migrer vers les sites articulaires, notamment g

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6

Kirchem, Antje. "Investigation of the signalling pathways coupled to the eotaxin receptor CCR3 in human eosinophils." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406094.

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7

Araújo, Jéssica Maria Dantas. "Participação do receptor CCR3 na migração de eosinófilos induzida por estrogênio para o útero de camundongos C57/BL6 ovariectomizados." Pós-Graduação em Ciências Fisiológicas, 2017. https://ri.ufs.br/handle/riufs/6889.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Eosinophils are commonly described as cells from innate immunity that act on parasitic infections and lung diseases. However, in recent years, new functions are being added to these cells, among them, the maintenance of reproductive homeostasis. In addition, since the 1960s, studies have shown the estrogen relationship and the selective eosinophils migration to the uterus of castrated rats. The elucidation of the mechanism for the migration of these cells appears to be based on findings showing that the CCR3 receptor

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8

Pope, Samuel M. "Specific Role of Eotaxin-1 and Eotaxin-2 in Allergic Pulmonary Eosinophilia." Cincinnati, Ohio : University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1098472372.

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9

SANTUCCI, MARILINA BENEDETTA. "Ruolo della sfingosina 1-fosfato nella risposta immunitaria all’ infezione da mycobacterium tuberculosis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2004. http://hdl.handle.net/2108/208530.

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In questa tesi è stato studiato il ruolo della sfingosina 1-fosfato (S1P) nella risposta immunitaria durante l’infezione da M. tuberculosis. La S1P è un lipide bioattivo che regola diverse funzioni biologiche cellulari. In questo contesto, è stata analizzata l’attività anti-micobatterica in cellule della linea monocito/macrofagica, THP-1 ed in una linea tumorale di cellule dell’epitelio alveolare, A549 infettate con il ceppo patogeno di M. tuberculosis H37Rv e stimolate con S1P. La crescita di M. tuberculosis è stata valutata tramite il saggio delle unità formanti colonia ed i risultati di que

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10

Apel, Anna-Katharina [Verfasser]. "Biophysical and structural analysis of the chemokine receptors CCR2A and CCR3, leading to a 2.7 Å resolution structure of CCR2A / Anna-Katharina Apel." Ulm : Universität Ulm, 2019. http://d-nb.info/1188320963/34.

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11

Titz, Tiago de Oliveira. "Avaliação fenotípica e funcional dos eosinófilos da dermatite atópica do adulto." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-20052015-121525/.

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Introdução: A dermatite atópica (DA) é uma doença cutânea inflamatória de caráter crônico, recidivante, em que o prurido intenso e a xerose cutânea são frequentes. A etiopatogenia da DA é multifatorial, envolvendo fatores genéticos, ambientais e imunológicos. Eosinófilos são leucócitos polimorfonucleares multifuncionais que estão implicados na patogênese de diversos processos inflamatórios, incluindo a DA. Além da produção e secreção de diversas proteínas presentes nos grânulos citoplasmáticos, os eosinófilos também apresentam potencial para secretar metaloproteinases, enzimas proteolíticas qu

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12

Schauren, Juliana da Silveira. "Estudo dos polimorfismos CCR2-64I, CCR5-59353, CCR5-59356, CCR5-59402 e CCR5-59653 em pacientes com lúpus eritematoso sistêmico do sul do Brasil." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/78127.

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O Lúpus Eritematoso Sistêmico (LES) é uma doença autoimune inflamatória crônica que possui uma etiopatogênese complexa. Diversos fatores participam da patogênese da doença, dentre eles alterações no balanço de citocinas e quimiocinas. As quimiocinas e seus receptores são fundamentais na regulação da migração de leucócitos durante a inflamação e acredita-se que elas possam ter um papel importante na patogênese de doenças autoimunes, inclusive no LES. Diversos estudos abordaram o papel de quimiocinas e seus receptores no LES, porém, principalmente se tratando dos receptores de quimiocinas CCR5 e

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13

Sato, Wakiro. "Human Th17 Cells Are Identified as Bearing CCR2+CCR5- Phenotype." Kyoto University, 2008. http://hdl.handle.net/2433/124335.

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14

Sohy, Denis. "Etude de la dimérisation des récepteurs aux chimiokines CCR2, CCR5 et CXCR4." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210282.

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La dimérisation des récepteurs couplés aux protéines G est un nouveau concept apparu dans la littérature au cours des quelques années qui ont précédé le début de notre travail. Bien qu’il soit clairement établi que les récepteurs sont capables de former des homo et des hétérodimères, les conséquences fonctionnelles de telles interactions demeurent souvent peu claires. Dans une étude précédente, le laboratoire d’accueil a montré que les récepteurs aux chimiokines CCR2 et CCR5 forment des homo et des hétérodimères de manière constitutive et identifié une coopérativité négative de liaison de natu

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15

Longden, James. "Quantitative approaches to the study of the trafficking of CCR1 and CCR5." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437076.

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16

Zambra, Francis Maria Báo. "Influência dos genes CCR2 e CCR5 em hiperplasia e câncer de próstata." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/69706.

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A hiperplasia prostática benigna (HPB) e o câncer de próstata (CaP) são duas condições crônicas muito comuns em homens com idade avançada e têm sido relacionadas a processos inflamatórios. As quimiocinas são reconhecidas como mediadores críticos da resposta inflamatória por regular a migração das células imunológicas através da ativação de receptores de quimiocinas na superfície destas células. As quimiocinas estão relacionadas à patogênese tumoral, embora não seja claro de que modo afetam a progressão tumoral humana. O objetivo desse estudo foi investigar a associação de dois polimorfismos de

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17

Manin, Graziele Zenaro. "Identificação dos componentes do Sistema Imune que participam na resistência de camundongos em modelo de infecção letal por Legionella longbeachae." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-21052014-153321/.

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A doença dos legionários consiste em uma broncopneumonia severa e atípica, que acomete de 2 a 7% das pessoas infectadas com Legionella spp e que apresenta taxa de mortalidade que varia de 5 a 30%, sendo considerada uma importante causa de morbidade e mortalidade mundial. A patologia causada pela espécie L. pneumophila tem sido amplamente estudada em modelos experimentais e suas características clínicas foram extensivamente descritas. No entanto, este modelo não representa adequadamente a doença que acomete seres humanos, pois L. pneumophila não é letal aos camundongos como é para humanos. Rece

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18

Opalek, Judy Marcus. "I. Differential gene expression in human peripheral blood monocytes and alveolar macrophages II. Macrophage colony-stimulating factor is important in the development of pulmonary fibrosis." Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1075754091.

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Thesis (Ph. D.)--Ohio State University, 20043.<br>Title from first page of PDF file. Document formatted into pages; contains xiv, 115 p.; also includes graphics. Includes abstract and vita. Advisor: Clay B. Marsh, Dept.of Pathology. Includes bibliographical references (p. 102-115).

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19

Simonis, Christopher. "Molekulare Klonierung, stabile Transfektion und funktionelle Expression der murinen Chemokinrezeptoren Ccr2 und Ccr5." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-99950.

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20

Leach, Katie. "Pharmacological analysis of the CC chemokine receptors, CCR4 and CCR5 signalling properties and receptor-drug interactions." Thesis, University of Reading, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427859.

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21

Su, Yung-Chang University of New South Wales &amp Garvan Institute of Medical Research St Vincent's Clinical School UNSW. "Immune regulation in mouse models of allergic asthma." Awarded by:University of New South Wales & Garvan Institute of Medical Research. St. Vincent's Clinical School, 2006. http://handle.unsw.edu.au/1959.4/26978.

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Allergic asthma is an immunological disease, mediated by CD4+ Th2 cells, and its prevalence has increased over recent decades. Features of allergic asthma include airway hyperresponsiveness (AHR), airway eosinophilia, excessive airway mucus production, and increased IgE and Th2 cytokine levels. Airway remodeling with pulmonary fibrosis is noted in the progress of asthma. In this thesis, a murine model of allergic asthma was used to investigate the effect of cyclophosphamide (CY) on asthma and the involvement of regulatory T cells (Treg), and the role of Granulocyte-macrophage colony stimulatin

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22

Buson, Genny. "Studio di polimorfismi in geni coinvolti in patologie oculari angioproliferative." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3422745.

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The ocular angioproliferative diseases are multifactorial diseases, characterized by a progressive degeneration of cells in the macular region of the retina which permit distinct and central vision. This means that people with these diseases gradually lose their "high definition" vision guaranteed by the macula. The most frequent cause of macular degeneration is the age-related macular degeneration (AMD), which usually affects people older than 50 years and is the leading cause of legal blindness in the elderly population. The macula may also be affected by pathology in diabetic retinopathy

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23

SANTOS, Erinaldo Ubirajara Damasceno dos. "Estudo de associação de polimorfismos nos genes CCR2 e CCR5 com o desenvolvimento de lesões cervicais induzidas pelo HPV." Universidade Federal Rural de Pernambuco, 2016. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4811.

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Submitted by Mario BC (mario@bc.ufrpe.br) on 2016-06-17T13:30:57Z No. of bitstreams: 1 Erinaldo Ubirajara Damasceno dos Santos.pdf: 5711027 bytes, checksum: 05684bbb6abc042b66317984510ed3df (MD5)<br>Made available in DSpace on 2016-06-17T13:30:57Z (GMT). No. of bitstreams: 1 Erinaldo Ubirajara Damasceno dos Santos.pdf: 5711027 bytes, checksum: 05684bbb6abc042b66317984510ed3df (MD5) Previous issue date: 2016-02-23<br>Cervical cancer (CC) affects about half a million women each year worldwide. The main etiological agent that can lead to the development of the CC is the human papillomavirus

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24

Kramp, Birgit [Verfasser]. "Establishing the interaction between the CC chemokine ligand 5 and the receptors CCR1 and CCR / Birgit Kramp." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1049557794/34.

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25

Hirata, Bruna Karina Banin. "Estudo de associação dos polimorfismos genéticos CCR2-V64I e CCR5-Delta32 com suscetibilidade e parâmetros clinicopatológicos do câncer de mama." Universidade Estadual de Londrina. Programa de Pós- Graduação em Patologia Experimental, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000190140.

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Entre os diversos tipos de cânceres, o de mama representa um grave problema de saúde pública correspondendo ao segundo tipo mais freqüente no mundo e o primeiro na população feminina. As células tumorais podem expressar receptores de quimiocinas, tais como o CCR2 e o CCR5, que estão implicados na progressão tumoral, podendo modular não apenas o recrutamento leucocitário, mas também a angiogênese, invasão e proliferação de células tumorais. Polimorfismos em muitos destes receptores são considerados fatores de risco para o desenvolvimento de diferentes tipos de câncer. A proposta deste estudo fo

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26

Domínguez, Hernández Francisco. "Implicación de las quimoquinas IL-8, MCP-1, rantes, los receptores CXCR1, CXCR4, CCr2, CCr5 y el factor IGFBP-rP1 en la interfase materno-embrionaria." Doctoral thesis, Universitat de València, 2003. http://hdl.handle.net/10803/10135.

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La implantación embrionaria es la fijación del blastocisto al endometrio materno. El conocimiento de los factores moleculares implicados en su regulación es crucial para comprender los mecanismos que controlan la reproducción humana Las quimoquinas y sus receptores participan activamente en este proceso así como otros factores como IGFBP-rP1.Los objetivos principales de la tesis doctoral fueron los siguientes - Investigar la expresión y localización de la quimoquinas IL-8, MCP-1, RANTES y SDF-1 en el endometrio humano.- Estudiar la expresión y localización de los receptores de las quimoquinas

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27

John, Bangan. "Association Among CCR5 Genotypes, CCR5 Expression, And In Vitro HIV Infection." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1365888090.

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28

Giongo, Cíntia de Oliveira. "Caracterização imunogenética de variantes dos genes CCR2, CCR5 e HLA-G como potenciais alvos para diagnóstico, prognóstico e tratamento do câncer de mama feminino esporádico e familial." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/78137.

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O câncer de mama é a neoplasia mais comum entre as mulheres. Sua etiologia é complexa, onde tanto fatores ambientais como genéticos podem contribuir para o desenvolvimento tumoral. Estima-se que 5 a 10% dos casos de carcinomas de mama sejam representados pelos carcinomas de mama familial e 90 a 95% sejam representados pelos carcinomas de mama esporádicos. Independente da etiologia, um dos principais agravantes é consequência da habilidade das células tumorais metastizar. Mutações podem levar a mudança ou perda de expressão de diferentes genes e isto possibilita que as células adquiram particul

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29

Fish, Richard James. "RANTES derivatives and CCR5." Thesis, University of York, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369362.

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30

Müller, Christine [Verfasser], and Gernot [Akademischer Betreuer] Zissel. "Charakterisierung CCR6-positiver T-Zellen." Freiburg : Universität, 2011. http://d-nb.info/1123463107/34.

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31

Arnatt, Christopher Kent. "DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/517.

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The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in order to develop potential therapeutics and probes. First, a series of novel compounds was designed by using pharmacophore-based drug design based upon known CCR5 antagonists and molecular modeling studies of the CCR5 receptor’s three-dimensional conformation. Once synthesized, these compounds were t

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32

Basquin, Jérôme. "Etude structurale du complexe CCR4-NOT." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ084/document.

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Le recyclage des ARN débute par un étape de déadenylation ou la queue poly (A) est enzymatiquement clivée. La deadenylation est l’étape limitante dans le processus de dégradation des ARN. In vivo la deadenylation s’effectue successivement par les complexes multi-protéiques Pan2-Pan3 et Ccr4-Not. Le complexe Ccr4-not est conservé chez les eucaryotes et considéré comme le complexe prédominant responsable de l’activité de déadenylation dans la cellule. Le complexe est compose de neuf protéines organisées autour de la protéine d’échafaudage Not1. Le complexe comprend quatre modules distincts ; le

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33

Maier, Corinna. "Expressionsanalyse des Chemokinrezeptors CCR6 auf Fibroblasten." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-60178.

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34

José, de Pessoa Saldanha Carlos. "Avaliação da mutação ccr532 do receptor da quimiocina como marcador genético-histórico na população de Triunfo Pernambuco." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/6316.

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Made available in DSpace on 2014-06-12T18:04:10Z (GMT). No. of bitstreams: 2 arquivo3738_1.pdf: 896817 bytes, checksum: 7cd3fad40aa580f879fae31cec4ad007 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008<br>O gene ccr5 codifica o receptor b-quimiocina 5 (CCR5), uma proteína transmembrânica que age como principal co-receptor para os vírus HIV-1, Variola major e para a bactéria Yersinia pestis, nos macrófagos e monócitos humanos. Uma deleção de 32 pares de bases neste gene dá origem ao alelo mutante ccr532 cuja presença, em homozigose

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35

Dorman, Klara [Verfasser], and Sebastian [Akademischer Betreuer] Kobold. "Kombinierte Expression von epithelial cell adhesion molecule (EpCAM)-spezifischem chimärem Antigenrezeptor mit den Chemokinrezeptoren CCR4, CCR8 und CXCR6 in der T-Zell-basierten Immuntherapie von murinen Tumormodellen / Klara Dorman ; Betreuer: Sebastian Kobold." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1232645435/34.

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Knipfer, Lisa [Verfasser], Stefan [Akademischer Betreuer] Wirtz, and Falk [Gutachter] Nimmerjahn. "The role of the C-C type chemokine receptors CCR4 and CCR8 in migration and effector function of innate lymphoid cells type 2 (ILC2s) / Lisa Knipfer ; Gutachter: Falk Nimmerjahn ; Betreuer: Stefan Wirtz." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1224356195/34.

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Barmania, Fatima. "Analysis of CCR5 diversity in the South African population." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/31127.

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Infection with the human immunodeficiency virus (HIV) constitutes a global pandemic, and South Africa forms part of the region known to house over two-thirds of HIV infected individuals worldwide. In the early stages of infection, the C-C chemokine receptor type five (CCR5) is the major HIV-1 co-receptor. The importance of this receptor in HIV infection and disease progression was recognised with the discovery of the CCR5 delta 32 (Δ32) allele. Individuals homozygous for this mutation lack functional CCR5 receptors. Consequently, they are almost completely resistant to HIV infection, while the

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38

Rodrigues, Erika Cruz Vicente. "Avaliação de empresas: CCR." reponame:Repositório Institucional do BNDES, 2014. https://web.bndes.gov.br/bib/jspui/handle/1408/7028.

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Valuation é o termo em inglês para o método utilizado para determinar o preço justo a ser pago por um ativo. Existem três métodos mais conhecidos para avaliação: a avaliação pelo método de fluxo de caixa descontado, avaliação relativa e avaliação por direitos contingentes (opções reais). Este trabalho é baseado na avaliação pelo método de fluxo de caixa descontado na análise da empresa CCR, uma das maiores empresas de concessão de infraestrutura do mundo. Após analisar os demonstrativos financeiros da companhia e, efetuar uma análise do panorama do setor de exploração de rodovias, serão realiz

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39

Martinelli, Roberta. "Molecular characterisation of the chemokine receptor CCR2." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398841.

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40

Bryce, Steven Alan. "Regulation of the bioavailability of CCR7 ligands." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5904/.

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The efficient functioning of the immune system is dependent on the coordinated movement and positioning of immune cells. These cells patrol the body and facilitate the clearance of pathogens, whilst maintaining self-tolerance and inducing adaptive immunity. The coordinated migration of cells into and within tissues is mediated by chemokines, a family of small chemotactic cytokines that are potent inducers of cellular movement. Chemokines and their cognate receptors have been shown to play key roles in health, and in a broad spectrum of diseases. After their secretion, chemokines can be control

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Sax, Michael John. "The CCL5-CCR5 Axis in Breast Cancer." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/365646.

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Cancer is one of the leading underlying causes of death worldwide. Despite decades of research, cancer is predicted to be the leading cause of death by the year 2020. Anti angiogenic therapies that target the key signalling molecule, vascular endothelial growth factor (VEGF) have shown promise in the treatment of some solid tumours, resulting in increased progression-free survival times in patients. However, there are several significant problems with current anti-angiogenic therapies, such as the phenomenon of resistance. Tumours can be divided into those that are intrinsically nonresponsive

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42

De, Poorter Cédric. "Mécanismes d'activation et interactions fonctionnelles hétérologues des récepteurs aux chimiokines." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209589.

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Mécanismes d’activation et conséquences fonctionnelles de la dimérisation des récepteurs aux chimiokines<p><p>Les chimiokines sont de petites protéines qui régulent la migration des cellules immunitaires. Elles exercent leur action en se liant à des récepteurs appartenant à la famille des récepteurs couplés aux protéines G (RCPG) dont la fonction est intimement liée à la régulation des cellules immunitaires. Notre laboratoire étudie depuis plusieurs années les relations reliant la structure et la fonction des récepteurs aux chimiokines. Ces dernières années, un nouveau concept est venu révolut

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Yamamoto, Takamasa. "Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225454.

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Guo, Yanping. "The mechanism of Nov (CCN3) function in haematopoiesis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:5785f3b9-3206-4bb4-b486-d90cded680f8.

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Haematopoietic stem cells (HSC) are strictly regulated by intrinsic regulators and extrinsic signals from the microenvironment. Nov (CCN3), a matricellular protein of the CCN family, has been reported as a suppressor gene in solid tumours and chronic myeloid leukaemia (CML). Recent study identified Nov as a positive regulator in human cord blood CD34+ stem cells. However, the functions of Nov in haematopoiesis and adult HSC remain largely unknown.

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Castan, Laure. "De l'allergie alimentaire à l'asthme : rôle de CCR9." Thesis, Nantes, 2017. http://www.theses.fr/2017NANT1018/document.

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Aujourd’hui, l’allergie est classée 4ème maladie mondiale en termes de morbidité par l’OMS. Les allergies et leur évolution naturelle (marche atopique) sont devenues un problème majeur de santé publique particulièrement dans les pays industrialisés. La marche atopique se manifeste par l’évolution de la dermatite atopique et/ou des allergies alimentaires chez le jeune enfant vers des allergies respiratoires comme l’asthme ou la rhinite allergique plus tard dans l’adolescence. Ce passage pourrait impliquer un chimiotactisme contrôlé par le système chimiokine/récepteurs de chimiokine. A l’aide d’

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Castanheira, Fernanda Vargas e. Silva. "Papel protetor do receptor quimiotático CCR5 durante a sepse experimental." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-10012017-100344/.

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A sepse é uma resposta inflamatória sistêmica resultante da inabilidade do sistema imune em controlar uma infecção, onde a taxa de sobrevida está associada ao recrutamento de neutrófilos para o local da infecção. Tem sido demonstrado que a expressão de receptores quimiotáticos pode ser alterada durante a sepse. Neutrófilos de animais naives respondem às quimiocinas CXC, mas são irresponsivos às quimiocinas CC. Entretanto, dados do nosso laboratório mostram que a expressão de CXCR2 é reduzida na sepse, prejudicando a migração de neutrófilos para o foco da infecção. Além disso, ocorre o aparecim

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Costa, Giselle Calasans de Souza. "Investigação de mutações nos genes da CCR5 e langerina e suas associações com a infecção pelo HIV-1." reponame:Repositório Institucional da FIOCRUZ, 2012. https://www.arca.fiocruz.br/handle/icict/4243.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-07-25T20:46:06Z No. of bitstreams: 1 Giselle Calasans Investigação de mutacçoes nos genes....pdf: 17299730 bytes, checksum: b9919577a31cf080e622e852dc432578 (MD5)<br>Made available in DSpace on 2012-07-25T20:46:06Z (GMT). No. of bitstreams: 1 Giselle Calasans Investigação de mutacçoes nos genes....pdf: 17299730 bytes, checksum: b9919577a31cf080e622e852dc432578 (MD5) Previous issue date: 2012<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>O HIV-1 é o agente etiológico da AI

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Le, Dréau Gwenvaël. "NOV/CCN3 et système nerveux central : étude du rôle de NOV/CCN3 dans les précurseurs de neurones granulaires et des astrocytes." Paris 6, 2008. http://www.theses.fr/2008PA066063.

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NOV/CCN3 est une protéine sécrétée et multifonctionnelle impliquée dans le développement de différents tissus. Le système nerveux central représentant l’un de ses sites majeurs d’expression au cours du développement, nous avons ainsi émis l’hypothèse que NOV participe au développement de ce tissu. Les résultats obtenus en étudiant le rôle potentiel de NOV durant la phase postnatale de développement du cervelet chez le rat suggèrent que NOV participe à la mise en place des neurones granulaires en inhibant la prolifération et stimulant la migration de leurs précurseurs. Par ailleurs, nous avons

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Chelli, Maurice. "Étude de l'oligomérisation du récepteur de chimiokines CCR5 : implication dans l'entrée du virus de l'immunodéficience humaine." Paris 6, 2003. http://www.theses.fr/2003PA066051.

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Frank, Sunna [Verfasser]. "Die Bedeutung der Chemokinrezeptoren CCR7 und CXCR4 sowie des CCR7-Liganden CCL21 für die Ausbreitung des duktalen Adenokarzinoms des Pankreas / Sunna Frank." Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1019984872/34.

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